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macro_split/validation_output/summary.csv
lingyuzeng f6bf9e85a3 chore(validation-output): add gt3 fragment export 
Track refreshed validation outputs and add a filtered fragment
library export that retains only side-chain fragments with more
than 3 heavy atoms.
2026-03-19 21:20:56 +08:00

3.2 MiB
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1idml_idchembl_idmolecule_namesmilesclassificationring_sizeprimary_reason_codeprimary_reason_messageprocessing_statuserror_messagenum_sidechainscleavage_positionsnumbered_image_pathprocessed_at
21ML00000819CHEMBL1735765C[C@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
32ML00003370O=C(C[C@@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@@H]2CCCN2C1=O)N[C@@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
43ML00007631C/C=C1\C(OC2OC(CO)C(O)C(O)C2O)OC=C2C(=O)OCC(C)C3CC(OC(=O)CC21)C(C)C3COnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
54ML00008564C[C@@H]1C[C@](O)([C@@H](C)Cl)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
65ML00004196O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(Oc4c(C(=O)OC[C@H]5O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]5O)cc(O)c(O)c4O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
76ML00009127O=C1NC[C@H](c2ccccc2)OC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
87ML00007255CO[C@H]1/C=C\CC/C=C\C(=O)O[C@@H](/C(C)=C/[C@H](C)C(=O)/C=C/CC2CC(=O)NC(=O)C2)[C@@H](C)[C@@H]1Ostandard_macrolactone12.0success4.0[3, 4, 5, 6]ring_size_12/standard/numbered/ML00007255_numbered.png2026-03-19 06:54:43.464482
98ML00007092C[C@@H]1COC(=O)[C@@H](CC(=O)OC(C)(C)C)C/C=C\C[C@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
109ML00007357CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)CCCCCC/C=C/[C@H]1Cstandard_macrolactone12.0success2.0[3, 4]ring_size_12/standard/numbered/ML00007357_numbered.png2026-03-19 06:54:43.498665
1110ML00010831CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@](C)(O)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010831_numbered.png2026-03-19 06:54:43.540237
1211ML00008439CC[C@]1(O)C[C@@H](C)[C@](C)(OC(C)=O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
1312ML00008247CC1CCC(O)CCCCc2cc(O)cc(O)c2C(=O)O1standard_macrolactone12.0success2.0[3, 6]ring_size_12/standard/numbered/ML00008247_numbered.png2026-03-19 06:54:43.571589
1413ML00007684CC(=O)O[C@H]1/C=C/C[C@@H](/C(C)=C/C=C/CC[C@H]2O[C@@H]2C[C@H](C)O)OC(=O)CCCC[C@@]1(C)Ostandard_macrolactone12.0success4.0[3, 7, 8, 8]ring_size_12/standard/numbered/ML00007684_numbered.png2026-03-19 06:54:43.604723
1514ML00006968O=C1O[C@@H](c2ccccc2)C[C@@H](O)C(=O)CCCCc2ccccc21standard_macrolactone12.0success3.0[3, 5, 6]ring_size_12/standard/numbered/ML00006968_numbered.png2026-03-19 06:54:43.634285
1615ML00010986CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H](CO)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cc(O)c(Br)cc1Brnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
1716ML00009158O=C(Oc1c(O)cc2c(c1O)-c1c(cc(O)c(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](O)[C@H](OC2=O)[C@@H]1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
1817ML00007479C/C(=C\[C@@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@H]1OC(=O)/C=C\CC/C=C\C=C/[C@@H]1Cstandard_macrolactone12.0success2.0[3, 4]ring_size_12/standard/numbered/ML00007479_numbered.png2026-03-19 06:54:43.674961
1918ML00008365C=COCOc1cc(O)c2c(c1)CCCCCCC[C@@H](C)OC2=Ostandard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00008365_numbered.png2026-03-19 06:54:43.696244
2019ML00006718C=C1NC(=O)[C@@H](CCCc2ccc(OC)cc2)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C)NC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
2120ML00008270C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC1=O)[C@@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
2221ML00006916CC(=O)O[C@@]1(C)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC(=O)[C@@](O)([C@@H](C)O)C[C@H]1C)[C@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
2322ML00004204O=C(O)C[C@@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1C(=O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
2423ML00006911CC(=O)O[C@@H]1/C=C\C[C@H](/C(C)=C/C=C/[C@@H](C)O)OC(=O)C[C@H](O)CC[C@H]1Cstandard_macrolactone12.0success4.0[3, 7, 8, 11]ring_size_12/standard/numbered/ML00006911_numbered.png2026-03-19 06:54:43.757866
2524ML00004074O=C1OC[C@@H]2O[C@@H](O)[C@H]3OC(=O)c4cc(O)c(O)c5c4[C@@H]4C(=CC(=O)[C@](O)(O5)C4(O)O)C(=O)O[C@H]2[C@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]2C1=CC(=O)[C@](OC(=O)c1cc(O)c(O)c(O)c1)(O3)C2(O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
2625ML00007454CC/C=C\C=C/C(=O)N/C=C/C[C@@H]1C[C@H](O)[C@H](C)C/C=C\Cc2cccc(O)c2C(=O)O1standard_macrolactone12.0success3.0[3, 5, 6]ring_size_12/standard/numbered/ML00007454_numbered.png2026-03-19 06:54:43.799777
2726ML00001010CHEMBL2381165CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4ccc(I)c(O)c4)O[C@@]1(C3)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
2827ML00007310O=C(C[C@@H]1C/C=C\C[C@H](Cc2ccc(F)cc2)C(=O)OCCNC1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
2928ML00008082C[C@@H]1CCCCC[C@H](O)C(=O)[C@H](O)CC(=O)O1standard_macrolactone12.0success4.0[3, 9, 10, 11]ring_size_12/standard/numbered/ML00008082_numbered.png2026-03-19 06:54:43.848780
3029ML00008522C=C1C/C(=C\C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@@]1(C)OC(C)=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
3130ML00010295C[C@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
3231ML00010723CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](OC(C)=O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010723_numbered.png2026-03-19 06:54:43.904336
3332ML00008198C[C@@H]1CCC[C@@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success3.0[3, 7, 9]ring_size_12/standard/numbered/ML00008198_numbered.png2026-03-19 06:54:43.932907
3433ML00007297O=C(C[C@@H]1C/C=C\CCC(=O)OC[C@H](Cc2ccccc2)NC1=O)N[C@@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
3534ML00008666C/C=C1\C[C@H](C)[C@](C)(O)C(=O)OCC2=CCN3C[C@@H](O)[C@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
3635ML00008211C[C@H]1CCC(=O)[C@@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success4.0[3, 6, 7, 9]ring_size_12/standard/numbered/ML00008211_numbered.png2026-03-19 06:54:43.978112
3736ML00000775CHEMBL524666O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]2C1=CC(=O)C(O)(O)C2(O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
3837ML00008774C/C=C1\C(=O)O[C@@H]2CCN3CC[C@H](COC(=O)[C@@](C)(O)[C@H](C)[C@@H]1O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
3938ML00007487COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OC[C@H](NC(=O)[C@@H]2CCCN2C(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
4039ML00010905CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)[C@H](C)[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@H]1Cstandard_macrolactone12.0success7.0[3, 4, 7, 8, 8, 11, 12]ring_size_12/standard/numbered/ML00010905_numbered.png2026-03-19 06:54:44.044200
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4241ML00000379CHEMBL1730563O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
4342ML00008605C/C=C1\C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
4443ML00007359CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CCC[C@@H](O)/C=C\[C@@H]1Cstandard_macrolactone12.0success4.0[3, 4, 7, 11]ring_size_12/standard/numbered/ML00007359_numbered.png2026-03-19 06:54:44.099794
4544ML00006882CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@H](OC(=O)[C@@]3(C[C@@H]1C)O[C@@H]3C)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
4645ML00008745CC[C@H]1C(=O)O[C@H]2CCNC/C=C(/COC(=O)[C@@](C)(O)[C@H](C)[C@@H]1O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
4746ML00007463CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)NC[C@@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
4847ML00009978CC[C@H](O)C[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00009978_numbered.png2026-03-19 06:54:44.159610
4948ML00007833CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)Ostandard_macrolactone12.0success8.0[3, 4, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007833_numbered.png2026-03-19 06:54:44.205467
5049ML00002638CC[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002638_numbered.png2026-03-19 06:54:44.240880
5150ML00003972O=C(O)C[C@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2c(cc(O)c(O)c2O)[C@H]1[C@H](O)C(=O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
5251ML00001032CHEMBL39858CCCCCCC[C@H]1OC(=O)C[C@@H](OCOC)[C@H](Cc2ccccc2)N(C)C(=O)COC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
5352ML00001353CHEMBL1879879C[C@@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
5453ML00001015CHEMBL39969CCCCCCC[C@H]1OC(=O)C[C@@H](OCOC)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C)OC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
5554ML00002272CC(=C/C(C)=C/C[C@@H](O)C[C@H](C)O)/C=C(C)\C=C\C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1Cstandard_macrolactone12.0success4.0[3, 6, 8, 9]ring_size_12/standard/numbered/ML00002272_numbered.png2026-03-19 06:54:44.304294
5655ML00010699CC/C=C\C=C/CC[C@]1(C)C[C@H](O)[C@H](C)CC[C@H]2C[C@@H](C[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]3OC)C[C@@](O)(CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
5756ML00001034CHEMBL35924CCCCCCC[C@@H]1CC(=O)O[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)[C@H](O)CC(=O)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
5857ML00002341CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](C(C)C)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002341_numbered.png2026-03-19 06:54:44.351353
5958ML00008565C[C@@H]1C[C@](O)([C@@H](C)Cl)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
6059ML00008257C/C=C1/CC[C@@](C)(OC(C)=O)C(=O)OC[C@@]2(O)CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
6160ML00002410COC(=O)[C@H]1OC(=O)c2cc(O)c(O)c(O)c2[C@@H]1[C@H](CC(=O)O)C(=O)O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@@H](O)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
6261ML00009125O=C(Oc1c(O)cc(C(=O)O[C@@H]2O[C@@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]([C@H]2O)[C@@H]3O)cc1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
6362ML00007861C/C=C1/C[C@]2(CO2)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
6463ML00000727CHEMBL1714949CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
6564ML00008555CCOc1cc(O)c2c(c1)CCCCCCC[C@@H](C)OC2=Ostandard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00008555_numbered.png2026-03-19 06:54:44.416031
6665ML00001184CHEMBL3260944CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)/C(C)=C\CCc3coc(/C=C\CNC(=O)OC)n3)C[C@H](CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
6766ML00010864CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@@]3(O)CC(=O)O[C@](C)(CC/C=C/C=C/Br)C[C@@H](O)[C@H](C)CC[C@H](O3)[C@@H]2C)[C@H](O)[C@@H]1OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
6867ML00004305CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](C)(O)[C@H]3O[C@@H]3O[C@@H](C)[C@H](O)[C@@](C)(O)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
6968ML00008372C=CCOc1cc(O)c2c(c1)CCCCCCC[C@@H](C)OC2=Ostandard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00008372_numbered.png2026-03-19 06:54:44.457364
7069ML00008110CO[C@H]1CC(=O)C/C=C\[C@@H](O)CC(=O)O[C@H](C)C1standard_macrolactone12.0success4.0[3, 5, 7, 11]ring_size_12/standard/numbered/ML00008110_numbered.png2026-03-19 06:54:44.488612
7170ML00008595C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
7271ML00010832CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010832_numbered.png2026-03-19 06:54:44.535162
7372ML00002485C=C[C@H]1[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OCC[C@@H]3C(=CO[C@@H](O[C@H]4O[C@@H](CO)[C@H](OC(=O)/C=C/c5ccc(O)cc5)[C@@H](O)[C@@H]4O)[C@@H]3C=C)C(=O)OCC[C@H]21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
7473ML00007829C[C@H]1C[C@H](C)[C@H](O)[C@H](C)C(=O)O[C@H]([C@H](C)O)[C@@H](C)/C=C\C1=Ostandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007829_numbered.png2026-03-19 06:54:44.584981
7574ML00009409CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3O[C@@](O)(C2)[C@H](C)C(=O)O[C@@H](/C=C/C=C/Br)C/C(C)=C\C(=O)C3(C)C)[C@H](OC)[C@@H]1O[C@@H]1O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]1OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
7675ML00010323CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@@H]3CC[C@@H](C)[C@H](O)C[C@@](C)(/C=C/C=C\Br)OC(=O)C[C@](O)(C2)O3)[C@H](OC)[C@@H]1OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
7776ML00002100CHEMBL3260943CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)CCCCc3coc(CCCNC(=O)OC)n3)C[C@H](CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
7877ML00008594C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
7978ML00009042CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@H]3[C@@H]4C=C5C(=O)[C@H](C)[C@@H](O)CCC[C@H](/C=C/[C@H](C)O)OC(=O)C[C@H]5[C@@H]4C=C[C@@H]3[C@@H]2O)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00009042_numbered.png2026-03-19 06:54:44.645027
8079ML00004199O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]3[C@H]1OC(=O)c1cc(O)c(O)c(O)c1[C@H]1C(=O)[C@H](O)C[C@@]1(O)C(=O)O[C@@H]32)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
8180ML00006869CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@@](O)([C@@H](C)Cl)C[C@H]1C)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
8281ML00009097O=C1OC[C@@H]2O[C@H](OC(=O)c3cc(O)c(O)c(O)c3-c3c1cc(O)c(O)c3O)[C@H]1OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]1[C@H]2Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
8382ML00008021C[C@H]1CCC(=O)[C@@H]2CC(=O)c3c(cc(O)cc3O2)CC(=O)O1non_standard_macrocycle12.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
8483ML00008484C=C1C(=O)O[C@H]2CC(=O)n3ccc(c32)COC(=O)[C@](C)(OC(C)=O)[C@@H](C)[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
8584ML00002949CC(=O)C[C@]1(O)C(=O)C=C2C(=O)O[C@H]3[C@@H]4OC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)OC[C@H]3O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]4OC(=O)c3cc(O)c(O)c4c3[C@H]2[C@@]1(O)O4non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
8685ML00006623CCCCC[C@@H]1OC(=O)c2cc(ccc2C)Oc2ccc(O)c(C=O)c2/C=C\[C@@H]1Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
8786ML00004283CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](C)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00004283_numbered.png2026-03-19 06:54:44.726804
8887ML00000725CHEMBL1551810CC(C)(C)[C@@H]1COC(=O)[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
8988ML00009156O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9089ML00002473CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H](O[C@@H]4O[C@@H](C)[C@H](O)[C@@](C)(O)[C@H]4OC)[C@@](C)(O)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9190ML00001634CHEMBL3215313C=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2C2C(O)(O3)C3(O)OC4(C(=O)OC5C(O)COC54O)C12CC3=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9291ML00008381C[C@@H]1C(=O)OCC(=O)N(C)[C@@H](Cc2ccccc2)[C@@H](O)CC(=O)O[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9392ML00002486C=C[C@H]1[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OCC[C@@H]3C(=CO[C@@H](O[C@H]4O[C@@H](CO)[C@H](OC(=O)/C=C\c5ccc(O)cc5)[C@@H](O)[C@@H]4O)[C@@H]3C=C)C(=O)OCC[C@H]21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9493ML00009399COc1cc2cc(c1Cl)N1CC(=O)C(C)(O)C(=O)N(C)C(C)C(=O)O[C@@H](CC1=O)[C@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C/C=C(\C)C2OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9594ML00007486COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OCC(NC(=O)[C@H]2C(O)CCN2C(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9695ML00008617C/C=C1/C[C@@H](C)[C@@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9796ML00008568C[C@@H]1C[C@@]2(C)CC(=O)O[C@@H]3CCN4CC[C@H](COC(=O)[C@]1(C)O2)[C@H]34non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9897ML00001977CHEMBL1727544O=C(C[C@@H]1C/C=C\C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@@H](Cc2ccccc2)NC1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9998ML00010760CCC(=O)/C(C)=C/[C@H](O)C[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010760_numbered.png2026-03-19 06:54:44.843963
10099ML00007378CC[C@H]1O[C@H]1C[C@](C)(O)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00007378_numbered.png2026-03-19 06:54:44.883966
101100ML00002847C=C[C@@H]1[C@@H]2[C@@H]3/C=C\CC(=O)O[C@@]45C[C@@H](C)[C@@]6(O)[C@@H](C=C(CO)C[C@]7(O)C(=O)C(C)=C[C@H]76)[C@@H]4[C@@]5(C)COC(=O)[C@H]3[C@@H](/C=C/C=C/C=C/C=C/CCC)[C@@H]21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
102101ML00001002CHEMBL1079558O=C(C[C@H]1C/C=C/CCC(=O)O[C@@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
103102ML00010904CCC(=O)O[C@H]1/C=C\[C@H](C)[C@H](/C(C)=C/C=C/[C@H](C)C[C@H]2O[C@@H]2[C@H](C)[C@@H](O)CC)OC(=O)C[C@H](O)CC[C@]1(C)Ostandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010904_numbered.png2026-03-19 06:54:44.936867
104103ML00007464CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)NC[C@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
105104ML00008654C/C=C1/C[C@@H](C)[C@@H](O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
106105ML00010145C[C@@H]1CCCCCCCc2cc(OC(=O)c3ccc(Br)cc3)cc(OC(=O)c3ccc(Br)cc3)c2C(=O)O1standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00010145_numbered.png2026-03-19 06:54:44.971139
107106ML00008632C/C=C1/C[C@H](C)[C@](C)(O)C(=O)OCC2=CCN3CC[C@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
108107ML00002069CHEMBL3623739O=C(C#Cc1ccccc1)N/C=C/C[C@H]1C[C@@H](O)CC/C=C/Cc2cccc(O)c2C(=O)O1standard_macrolactone12.0success2.0[3, 5]ring_size_12/standard/numbered/ML00002069_numbered.png2026-03-19 06:54:45.003918
109108ML00009099O=C1OCC(O)C(C2OC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)c4c3C(=O)OC2C4O)OC(=O)c2cc(O)c(O)c(O)c2-c2cc1c(O)c(O)c2Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
110109ML00010687CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
111110ML00002129CHEMBL1669768Cc1ccc(S(=O)(=O)Oc2cc3c(c(OS(=O)(=O)c4ccc(C)cc4)c2)C(=O)O[C@H](C)CCCCCCC3)cc1standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00002129_numbered.png2026-03-19 06:54:45.041277
112111ML00009147O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)CO[C@H]([C@H]1O)[C@@H]2OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
113112ML00008590C/C=C1/C[C@@H](C)[C@](C)(O)C(=O)OC[C@H]2CCN3CC[C@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
114113ML00000521CHEMBL1710965O=C(N[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)OC1=O)OCC1c2ccccc2-c2ccccc21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
115114ML00007427CC/C=C\C=C/C(=O)N/C=C\C[C@H]1C[C@@H](O)[C@@H](C)C/C=C/Cc2ccc(F)c(O)c2C(=O)O1standard_macrolactone12.0success3.0[3, 5, 6]ring_size_12/standard/numbered/ML00007427_numbered.png2026-03-19 06:54:45.091327
116115ML00004086CC(C)(C)[C@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
117116ML00008195C[C@@H]1CCC[C@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success3.0[3, 7, 9]ring_size_12/standard/numbered/ML00008195_numbered.png2026-03-19 06:54:45.127160
118117ML00008761C[C@H]1C[C@@](O)([C@H](C)O)C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
119118ML00010273CC[C@H](O)[C@@H](C)[C@@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010273_numbered.png2026-03-19 06:54:45.173716
120119ML00010194O=C(C[C@@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](Cc2c[nH]c3ccccc23)NC1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
121120ML00008708C/C=C1\C(=O)OC2CCN3CCC(COC(=O)C(C)(O)C(C)C1O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
122121ML00006642C=C(C#N)CO[C@@H]1O[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]([C@@H]1O)[C@@H]2Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
123122ML00010903CC(=O)O[C@H]1/C=C\[C@H](C)[C@@H](/C(C)=C/C=C/[C@H](C)C[C@@H](C)/C=C(\C)[C@H](O)[C@H](C)O)OC(=O)C[C@@H](O)CC[C@@]1(C)Ostandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010903_numbered.png2026-03-19 06:54:45.233506
124123ML00008557COc1cc2c(c(OC)c1)C(=O)O[C@H](C)CCCCCCC2standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00008557_numbered.png2026-03-19 06:54:45.256640
125124ML00006605CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)N2CCC[C@@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
126125ML00007531CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H]([N+](C)(C)[O-])[C@@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)Ostandard_macrolactone12.0success8.0[3, 4, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007531_numbered.png2026-03-19 06:54:45.310686
127126ML00010688CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](c2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
128127ML00010465CCC[C@@H]1OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)C(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
129128ML00001862CHEMBL1606783CC(=O)C[C@H](O)CC(=O)[C@H]1OC(=O)CCCCCCCc2ccccc21standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00001862_numbered.png2026-03-19 06:54:45.345929
130129ML00002795CC/C=C/[C@H]1CCC[C@H](O[C@H]2C[C@@H](OC)[C@H](OC)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)[C@@H](O)[C@H]4C=C[C@H]3[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002795_numbered.png2026-03-19 06:54:45.382052
131130ML00007542CC[C@H]1OC(=O)[C@@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@H](C)C(=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007542_numbered.png2026-03-19 06:54:45.425827
132131ML00004056O=C1C[C@]2(O)OC(=O)[C@H](OC1=O)[C@H]2c1c(C(=O)O[C@H]2[C@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@@H](O[C@@H]2OC(=O)c2cc(O)c(O)c(O)c2)[C@H]3O)cc(O)c(O)c1Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
133132ML00004067O=C(O)C[C@@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]1[C@H](O)C(=O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
134133ML00008644C/C=C1/C[C@@H](C)[C@@](O)(CO)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
135134ML00008585C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
136135ML00008300C/C=C1/C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC1=O)[C@@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
137136ML00007794COc1cc(O)cc2c1C(=O)O[C@H](C)[C@@H](O)CCCCCC2standard_macrolactone12.0success2.0[3, 4]ring_size_12/standard/numbered/ML00007794_numbered.png2026-03-19 06:54:45.488282
138137ML00008471C/C=C1/C[C@H](C)[C@@](C)(OC(C)=O)C(=O)OCc2ccn3c2[C@H](CC3=O)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
139138ML00002692CCC(=O)C[C@H](O)C/C=C(C)/C=C(C)/C=C(C)/C=C/C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1Cstandard_macrolactone12.0success4.0[3, 6, 8, 9]ring_size_12/standard/numbered/ML00002692_numbered.png2026-03-19 06:54:45.527865
140139ML00007870C=C1C(=O)OCC2=CCN3CC[C@@H](OC(=O)[C@](C)(O)[C@]4(CO4)[C@H]1C)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
141140ML00000993CHEMBL8097CCCCCCC[C@H]1OC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C)OC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
142141ML00002404CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](C6CC6)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002404_numbered.png2026-03-19 06:54:45.575450
143142ML00010205CCC(O)C(C)C1OC1CC(C)/C=C/C=C(/C)C1OC(=O)CC(O)CCC(C)(O)C(O)CCC1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010205_numbered.png2026-03-19 06:54:45.615957
144143ML00006927CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@@](O)([C@@H](C)O)C[C@H]1C)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
145144ML00008606C[C@]1(O)C[C@]2(C)CC(=O)O[C@@H]3CCN4CC=C(COC(=O)[C@@]1(C)O2)[C@H]34non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
146145ML00008569C/C=C1/C(=O)O[C@@H]2CCN3CC[C@H](COC(=O)[C@@](C)(O)[C@H](C)[C@@H]1O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
147146ML00001884CHEMBL1094534PAECILOMYCIN BCOc1cc(O)c2c(c1)[C@@H]1O[C@@H]([C@@H](O)C[C@H]1O)[C@H](O)/C=C/C[C@H](C)OC2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
148147ML00004071O=C(O[C@@H]1[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC[C@@H](O2)[C@H]1OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
149148ML00000386CHEMBL1730133CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
150149ML00002723CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H]([N+](C)(C)[O-])[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002723_numbered.png2026-03-19 06:54:45.690948
151150ML00009696COc1cc2cc(c1Cl)N1CC(=O)[C@@](C)(O)C(=O)N(C)[C@@H](C)C(=O)O[C@@H](CC1=O)[C@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C\C=C(\C)C2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
152151ML00010191C[C@@H]1CCCCCCCc2cc(OCc3ccccc3)cc(OCc3ccccc3)c2C(=O)O1standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00010191_numbered.png2026-03-19 06:54:45.720666
153152ML00004051O=C(O)C[C@@H]1C(=O)O[C@@H]2[C@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]2[C@@H](OC(=O)c2cc(O)c(O)c4c2[C@@H]1[C@@](O)(C(=O)O)O4)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
154153ML00004020O=C(O)/C=C(\C(=O)O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@H](O)[C@@H](OC(=O)c1cc(O)c(O)c(O)c1)O2)[C@H]1c2c(cc(O)c(O)c2O)C(=O)O[C@H]1C(=O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
155154ML00002787CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](c6ccoc6)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002787_numbered.png2026-03-19 06:54:45.774025
156155ML00008417CC[C@@]1(O)C[C@@H](C)[C@@](C)(OC(C)=O)C(=O)OCC2=CC(=O)N3CC[C@@H](OC1=O)[C@@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
157156ML00008377C=C1C/C(=C\C)C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@]1(C)O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
158157ML00008500COC(=O)[C@@]1(O)CS[C@H]2CCC[C@H](C)OC(=O)Cc3cc(O)cc(O)c3C(=O)[C@@H]21standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00008500_numbered.png2026-03-19 06:54:45.819961
159158ML00004010O=C(O)/C=C(\C(=O)O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@@H](O)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O2)[C@H]1c2c(cc(O)c(O)c2O)C(=O)O[C@H]1C(=O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
160159ML00007866C/C=C1/C[C@]2(CO)O[C@@]2(C)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
161160ML00008207CC1CCCCCC(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00008207_numbered.png2026-03-19 06:54:45.861140
162161ML00009043CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](/C=C/[C@H](C)O)CCC[C@H](O)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00009043_numbered.png2026-03-19 06:54:45.894390
163162ML00009128O=C(C[C@H]1C/C=C\C[C@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
164163ML00008618C/C=C1/C[C@H](C)[C@@](O)(CO)C(=O)OCC2=CCN3CC[C@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
165164ML00008068C[C@@H]1C[C@H](O)CC(=O)C/C=C\[C@@H](O)CC(=O)O1standard_macrolactone12.0success4.0[3, 5, 7, 11]ring_size_12/standard/numbered/ML00008068_numbered.png2026-03-19 06:54:45.940038
166165ML00007556CC[C@H](O)[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@H](C)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success5.0[3, 4, 7, 8, 11]ring_size_12/standard/numbered/ML00007556_numbered.png2026-03-19 06:54:45.976391
167166ML00010835CC(=O)O[C@H]1/C=C\[C@H](C)[C@H](/C(C)=C/C=C/[C@@H](C)C[C@H](O)[C@H]2O[C@H](C)[C@@H](O)[C@@H]2C)OC(=O)C[C@H](O)CC[C@]1(C)Ostandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010835_numbered.png2026-03-19 06:54:46.017420
168167ML00004013O=C1O[C@H]2[C@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H](OC(=O)c3cc(O)c(O)c4c3[C@@H]3C1=CC(=O)[C@](O)(O4)C3(O)O)[C@@H]1OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC[C@H]2O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
169168ML00007917COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OC[C@H](NC(C)=O)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
170169ML00007581O=C(OC1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC(C2O)C1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
171170ML00009979CC(=O)O[C@H]1/C=C\[C@H](C)[C@H](/C(C)=C/C=C/[C@H](C)C[C@@H]2O[C@@H]2[C@H](C)[C@H](C)O)OC(=O)C[C@H](O)CC[C@@]1(C)Ostandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00009979_numbered.png2026-03-19 06:54:46.080301
172171ML00007171CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)N[C@@H](Cc2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
173172ML00004054O=C(O)C[C@]12OC(=O)[C@H](OC1=O)[C@H]2c1c(C(=O)O[C@H]2[C@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@@H](O[C@@H]2OC(=O)c2cc(O)c(O)c(O)c2)[C@H]3O)cc(O)c(O)c1Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
174173ML00008627C[C@@H]1[C@@H](O)[C@]2(C)CC(=O)O[C@@H]3CCN4CC=C(COC(=O)[C@@]1(C)O2)[C@H]34non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
175174ML00010861CCC(=O)[C@H](C)[C@H]1O[C@@H]1C[C@](C)(O)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010861_numbered.png2026-03-19 06:54:46.142139
176175ML00007584O=C(OC1C(O)C2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC(O2)C1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
177176ML00008490C=C1C/C(=C\C)C(=O)O[C@@H]2CC(=O)n3ccc(c32)COC(=O)[C@]1(C)OC(C)=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
178177ML00008670C=C1C/C(=C/C)C(=O)O[C@@H]2CCN3C[C@H](O)[C@@H](COC(=O)[C@]1(C)O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
179178ML00009500O=C1OC[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@H]1Cc1ccc(F)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
180179ML00006691CO[C@@H]1[C@@H](CO)O[C@@H](Oc2c(O)cc3c(c2O)C(=O)CCCCC[C@H](C)OC(=O)C3)[C@H](O)[C@H]1Ostandard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00006691_numbered.png2026-03-19 06:54:46.194926
181180ML00004200O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]3[C@@H]2OC(=O)[C@]2(O)C[C@H](O)C(=O)[C@H]2c2c(cc(O)c(O)c2O)C(=O)O[C@H]31)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
182181ML00007635C/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OC[C@H](C)[C@@H]3C[C@H](O)[C@H](C)[C@H]3COC(=O)C[C@H]21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
183182ML00007582O=C(O[C@@H]1[C@@H](O)[C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC[C@@H](O2)[C@H]1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
184183ML00000979CHEMBL1159467E181O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(Oc5c(C(=O)O)cc(O)c(O)c5O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2C2C1=CC(=O)C(O)(O)C2(O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
185184ML00007789COc1cc(O)cc2c1C(=O)O[C@H](C)C[C@@H](O)CCCCC2standard_macrolactone12.0success2.0[3, 5]ring_size_12/standard/numbered/ML00007789_numbered.png2026-03-19 06:54:46.250862
186185ML00008597C/C=C1\C[C@H](C)[C@@](C)(O)C(=O)OC[C@@H]2CCN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
187186ML00008655C/C=C1\C[C@@H](C)[C@@H](O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
188187ML00000322CHEMBL4062982CC(/C=C/C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(\C)C[C@@H]1C)=C\[C@@H](C)C/C=C/C(C)=C/[C@H](O)[C@@H](O)C[C@H](C)Ostandard_macrolactone12.0success4.0[3, 6, 8, 9]ring_size_12/standard/numbered/ML00000322_numbered.png2026-03-19 06:54:46.297022
189188ML00001202CHEMBL3260941CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)CCCCc3coc(/C=C\CNC(=O)OC)n3)C[C@H](CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
190189ML00008217C[C@H]1CC[C@@H](O)/C=C\C(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success3.0[3, 6, 9]ring_size_12/standard/numbered/ML00008217_numbered.png2026-03-19 06:54:46.332466
191190ML00007813CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1Cstandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007813_numbered.png2026-03-19 06:54:46.375056
192191ML00008559CC/C=C\CCC(=O)[C@@H]1/C=C\C/C=C\CCCCC(=O)O1standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00008559_numbered.png2026-03-19 06:54:46.396958
193192ML00010105CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)/C=C\[C@]2(CO2)[C@H](OC(C)=O)/C=C\[C@H]1Cstandard_macrolactone12.0success4.0[3, 4, 7, 11]ring_size_12/standard/numbered/ML00010105_numbered.png2026-03-19 06:54:46.430600
194193ML00008255C/C=C1\C[C@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
195194ML00002807CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@H]3[C@@H]4C=C5C(=O)[C@H](C)[C@@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)CCC[C@H](C6CC6)OC(=O)C[C@H]5[C@@H]4C=C(C)[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002807_numbered.png2026-03-19 06:54:46.473094
196195ML00008516COC(=O)[C@@H]1CSCc2ccccc2C(=O)OCC(NC(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
197196ML00005329CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(=O)NCCCC[C@H](NC(=O)c2ccc(C3(C(F)(F)F)N=N3)cc2)C(=O)N(C)CCN(C)C(=O)CCCC[C@H]2SC[C@H]3NC(=O)N[C@H]32)/C=C/[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00005329_numbered.png2026-03-19 06:54:46.527174
198197ML00008662C/C=C1/C[C@H](C)[C@](C)(O)C(=O)OCC2=CCN3C[C@@H](O)[C@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
199198ML00007113C[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
200199ML00009977CC[C@H](O)[C@@H](C)[C@@H]1O[C@@H]1CC/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00009977_numbered.png2026-03-19 06:54:46.579542
201200ML00007516CC(C)(C)[C@H]1COC(=O)CC/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
202201ML00007529CC[C@@H](C)[C@H]1NC(=O)[C@@H](C)[C@@H](O)C[C@H]([C@H](C)CCCC[C@H](C)O)OC(=O)[C@@H]2CCCN2C1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
203202ML00004076O=C1OC[C@@H]2O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@@H]3[C@@H]2OC(=O)c2cc3c(c(O)c2O)O[C@]2(O)C(=O)C=C1[C@H]3C2(O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
204203ML00006689CCCC[C@@H]1COC(=O)[C@H](CC(=O)NCc2ccc(Cl)cc2)C/C=C/CCC(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
205204ML00002088CHEMBL1396521O=C1OC[C@@H]2CCCN2C(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@@H]1Cc1ccc(F)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
206205ML00004207O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]([C@@H]1O)[C@@H]2OC(=O)[C@H]1CC(=O)c2oc(=O)c3cc(O)c(O)c(O)c3c21)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
207206ML00001703CHEMBL2152356O=C(C[C@@H]1C/C=C/CCC(=O)OC[C@@H]2CCCN2C1=O)NCc1ccc(Cl)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
208207ML00010635CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
209208ML00001056CHEMBL3400935C/C1=C\CCC(C)C(C)OC(=O)Cc2c(Cl)c(O)cc(O)c2C1=Ostandard_macrolactone12.0success4.0[3, 4, 8, 9]ring_size_12/standard/numbered/ML00001056_numbered.png2026-03-19 06:54:46.666715
210209ML00010545CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@@H](C)O)OC(=O)/C=C(\O2)[C@](C)(O)CC3(C)C)[C@@H]1C)c1cccc(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
211210ML00008599C/C=C1\C[C@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
212211ML00008664C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3C[C@@H](O)[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
213212ML00006867C/C=C1/C[C@@H](COC(C)=O)[C@@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
214213ML00006676CO/N=C/C=C\C(=O)NC/C=C/[C@@H]1OC(=O)c2c(O)cccc2/C=C\C=C/[C@H]2O[C@H]2[C@@H]1Ostandard_macrolactone12.0success2.0[3, 4]ring_size_12/standard/numbered/ML00006676_numbered.png2026-03-19 06:54:46.722258
215214ML00001250CHEMBL1714837CC(C)(C)[C@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
216215ML00009518CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@]2(C)C[C@@H](C)[C@@]3(O2)O[C@@]1(C)[C@H](O)[C@H]3Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
217216ML00007773O=C(C[C@@H]1C/C=C\CCC(=O)OC[C@@H]2CCCN2C1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
218217ML00008630C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
219218ML00003916CC/N=C1/O[C@H]2[C@H](O[C@@H]3[C@@H](C)[C@H](O[C@H]4C[C@@](C)(OC)[C@@H](O)[C@H](C)O4)[C@@H](C)C(=O)O[C@H](CC)[C@@]4(C)OC5(O[C@@]3(C)C[C@H]5C)[C@H](C)[C@@H]4C)O[C@H](C)C[C@@H]2N1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
220219ML00002350CC[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@H]4C(C)=C[C@H]3[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002350_numbered.png2026-03-19 06:54:46.791420
221220ML00008204C[C@@H]1CCC(=O)CCCCc2cc(O)cc(O)c2C(=O)O1standard_macrolactone12.0success2.0[3, 6]ring_size_12/standard/numbered/ML00008204_numbered.png2026-03-19 06:54:46.817748
222221ML00008206C[C@H]1CCCCCC(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00008206_numbered.png2026-03-19 06:54:46.844851
223222ML00007577O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]([C@H]2O)[C@H]1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
224223ML00001932CHEMBL1534142CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
225224ML00010415C[C@@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
226225ML00007093C[C@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
227226ML00001748CHEMBL2152364C[C@H]1C/C=C\C[C@@H](CC(=O)NCc2ccc(Cl)cc2)C(=O)OC[C@@H](c2ccccc2)NC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
228227ML00007658C/C(=C\[C@H](C)C(=O)CCCC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\C[C@@H](O)[C@@H]1Cstandard_macrolactone12.0success3.0[3, 4, 5]ring_size_12/standard/numbered/ML00007658_numbered.png2026-03-19 06:54:46.914199
229228ML00007360CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C/[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00007360_numbered.png2026-03-19 06:54:46.960640
230229ML00006750CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@H](NC)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)Ostandard_macrolactone12.0success8.0[3, 4, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00006750_numbered.png2026-03-19 06:54:47.012238
231230ML00008254C/C=C1\C[C@H](C)[C@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
232231ML00002951CC(=O)C[C@]1(O)C(=O)C=C2C(=O)O[C@H]3[C@@H]4OC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)OC[C@H]3O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]4OC(=O)c3cc(O)c(O)c4c3[C@H]2[C@]1(O)O4non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
233232ML00007474C/C(=C\[C@H](C)C(=O)/C=C/CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\[C@H](O)[C@@H](O)[C@@H]1Cstandard_macrolactone12.0success4.0[3, 4, 5, 6]ring_size_12/standard/numbered/ML00007474_numbered.png2026-03-19 06:54:47.080276
234233ML00009132O=C1O[C@H](c2ccccc2)CNC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@H]1Cc1ccc(F)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
235234ML00002990O=C(C[C@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@H](Cc2ccccc2)NC1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
236235ML00002848C=C/C=C\[C@H]1[C@H]2[C@@H](/C=C/C=C/C=C/CCC)[C@H]2[C@@H]2C(=O)OC[C@]3(C)[C@H]4[C@@H]5C=C(CO)C[C@]6(O)C(=O)C(C)=C[C@H]6[C@@]5(O)[C@H](C)C[C@]43OC(=O)C/C=C\[C@H]12non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
237236ML00010976CC1=C2CC(=O)O[C@@H]([C@@H](C)O)CC(=O)O[C@H]3C[C@@](O2)(O[C@H]([C@@H](C)CCCc2cccc(O)c2)[C@H]3C)C(C)(C)C1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
238237ML00008323CCCOc1cc(O)c2c(c1)CCCCCCC[C@@H](C)OC2=Ostandard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00008323_numbered.png2026-03-19 06:54:47.134006
239238ML00006800C=CCNC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OC[C@H](NC(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
240239ML00008631C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
241240ML00006883CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@]3(C[C@@H]1C)O[C@@H]3C)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
242241ML00007363CC[C@H](O)[C@H](O)C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00007363_numbered.png2026-03-19 06:54:47.195351
243242ML00008159COC1CCCC(C)OC(=O)Cc2cc(O)cc(O)c2C(=O)C1standard_macrolactone12.0success3.0[3, 7, 9]ring_size_12/standard/numbered/ML00008159_numbered.png2026-03-19 06:54:47.227446
244243ML00006714C/C=C1\C(=O)O[C@H]2CCN(C)C/C=C(/COC(=O)[C@@](C)(OC(C)=O)[C@@H](C)[C@@H]1OC(C)=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
245244ML00007481C/C(=C\[C@H](C)C(=O)/C=C/CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\C[C@@H](O)[C@@H]1Cstandard_macrolactone12.0success3.0[3, 4, 5]ring_size_12/standard/numbered/ML00007481_numbered.png2026-03-19 06:54:47.266521
246245ML00007430CC/C=C\C=C/C(=O)N/C=C\C[C@H]1C[C@H](O)[C@H](C)C/C=C\Cc2cccc(O)c2C(=O)O1standard_macrolactone12.0success3.0[3, 5, 6]ring_size_12/standard/numbered/ML00007430_numbered.png2026-03-19 06:54:47.297783
247246ML00006756CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@H](NC)[C@@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1Cstandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00006756_numbered.png2026-03-19 06:54:47.344803
248247ML00008268C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC1=O)[C@@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
249248ML00007634C/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OC[C@H](C)[C@@H]3[C@@H](O)C[C@H](C)[C@H]3COC(=O)C[C@H]21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
250249ML00010611COc1ccc([C@@H]2Cc3cc(O)cc(O)c3C(=O)O[C@H](c3ccc(O)cc3)Cc3cc(OC)cc(O)c3C(=O)O2)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
251250ML00009695COc1cc2cc(c1Cl)N1CC(=O)C(C)(O)C(=O)N(C)[C@@H](C)C(=O)O[C@@H](CC1=O)[C@@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C/C=C(\C)C2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
252251ML00008853CO[C@@H]1/C=C(/C)C[C@H](/C=C/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)C[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H]4NC(=O)O[C@@]4(C)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
253252ML00008102Cc1c(O)cc(O)c2c1C(=O)OCCC(=O)NCCSC2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
254253ML00008386COc1cc(O)c2c(c1)[C@@H]1O[C@@H]([C@@H](O)C[C@H]1O)[C@H](O)/C=C\C[C@H](C)OC2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
255254ML00008603C[C@@H]1[C@@H](C)[C@](O)(CCl)C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
256255ML00000973CHEMBL412564CC(=O)O[C@H]1[C@@H]2CO[C@@H]2[C@@H]2OCOCCOC(=O)O[C@H]3C(=O)[C@@]2(C)[C@@H]1[C@H](OC(=O)c1ccccc1)[C@]1(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c2ccccc2)c2ccccc2)C(C)=C3C1(C)Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
257256ML00007852C=C1C[C@](O)([C@H](C)Cl)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
258257ML00010802O=C(C[C@@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
259258ML00010859CC[C@H](O)[C@@H](C)[C@H]1O[C@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC(=O)[C@@](C)(O)[C@H](OC(C)=O)/C=C\[C@H]1Cstandard_macrolactone12.0success7.0[3, 4, 7, 8, 8, 9, 11]ring_size_12/standard/numbered/ML00010859_numbered.png2026-03-19 06:54:47.471706
260259ML00009344CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
261260ML00001102CHEMBL1159468O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(Oc4c(C(=O)O)cc(O)c(O)c4O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
262261ML00010684CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
263262ML00010957CCNC(=O)O[C@H]1/C=C/[C@H](C)[C@@H](/C(C)=C/C=C/[C@@H](C)C[C@H]2O[C@@H]2[C@H](C)[C@@H](O)CC)OC(=O)C[C@H](O)CC[C@@]1(C)Ostandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010957_numbered.png2026-03-19 06:54:47.539280
264263ML00004026O=C1C=C2C(=O)O[C@H]3[C@H](OC(=O)c4cc(O)c(O)c(O)c4)O[C@@H]4COC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)O[C@H]3[C@@H]4OC(=O)c3cc(O)c(O)c(O)c3[C@@H]2C(O)(O)C1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
265264ML00010074CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
266265ML00007034C=C1NC(=O)[C@H](CCCc2ccc(O)cc2)NC(=O)[C@H](C(C)C)OC(=O)[C@H](C)NC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
267266ML00008073C[C@H]1CCC[C@@H](O)/C=C\[C@H](O)/C=C\C(=O)O1standard_macrolactone12.0success3.0[3, 7, 10]ring_size_12/standard/numbered/ML00008073_numbered.png2026-03-19 06:54:47.593156
268267ML00002378CCC1CCCC(OC2CCC(N(C)C)C(C)O2)C(C)C(=O)C2=CC3C(C=C(C)C4CC(OC5OC(C)C(OC)C(OC)C5OC)CC43)C2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002378_numbered.png2026-03-19 06:54:47.628265
269268ML00001252CHEMBL1700973CC(C)(C)[C@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
270269ML00008171C[C@@H]1C/C=C/CCC(=O)N[C@H](c2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
271270ML00007033CC(=O)N1C(=O)SC[C@H]1C(=O)/C=C/C[C@H]1CC[C@H](C)/C=C\CC/C(C)=C\C(=O)O1standard_macrolactone12.0success3.0[3, 6, 11]ring_size_12/standard/numbered/ML00007033_numbered.png2026-03-19 06:54:47.673279
272271ML00001927CHEMBL1725121O=C1N[C@@H](c2ccccc2)COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
273272ML00008545C/C=C1\CC(C)C(C)C(=O)OCC2CCN3CCC(OC1=O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
274273ML00008262C/C=C1\C[C@@H](C)[C@](O)(CO)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
275274ML00008764C[C@@H]1[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC(=O)[C@@]1(O)CO)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
276275ML00008279C=C1C[C@@H](CC)C(=O)O[C@@H]2CC[C@]3(C)CC=C(COC(=O)[C@@]1(C)O)[N+]23[O-]non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
277276ML00008248C[C@H]1CCCCC[C@H](O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00008248_numbered.png2026-03-19 06:54:47.731121
278277ML00008933O=C(C[C@@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](Cc2ccccc2)NC1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
279278ML00000401CHEMBL288124CCCCCCC[C@H]1OC(=O)C[C@H](OCOC)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
280279ML00002278C/C1=C/C[C@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)OC(=O)CCC[C@H](OC(=O)/C=C/C(C)=C/C(C)=C/C(C)=C/C[C@H](O)C[C@@H](C)O)[C@@H](C)C1standard_macrolactone12.0success4.0[3, 6, 8, 9]ring_size_12/standard/numbered/ML00002278_numbered.png2026-03-19 06:54:47.777092
281280ML00010299C[C@@H]1COC(=O)[C@@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
282281ML00004064O=C(O)C[C@@H]1C(=O)O[C@@H]2[C@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]2[C@@H](OC(=O)c2cc(O)c(O)c4c2[C@H]1[C@H](O)C(=O)O4)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
283282ML00010328CCC(=O)[C@H](C)[C@@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@@H](O)CC[C@@](C)(O)[C@@H](O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010328_numbered.png2026-03-19 06:54:47.834721
284283ML00010984CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N[C@H](C(C)(C)C)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
285284ML00007148CO[C@H]1/C=C\CC/C=C\C(=O)O[C@@H](/C(C)=C/[C@H](C)C(=O)C[C@H](O)CC2CC(=O)NC(=O)C2)[C@@H](C)C1standard_macrolactone12.0success3.0[3, 4, 6]ring_size_12/standard/numbered/ML00007148_numbered.png2026-03-19 06:54:47.876311
286285ML00002064CHEMBL3623744O=C(C#Cc1ccccc1)N/C=C/C[C@H]1C[C@@H](O)CC/C=C/Cc2cc(F)ccc2C(=O)O1standard_macrolactone12.0success2.0[3, 5]ring_size_12/standard/numbered/ML00002064_numbered.png2026-03-19 06:54:47.905147
287286ML00006696C/C=C1\C(=O)O[C@H]2CC[N+]3(C)CC=C(COC(=O)[C@](C)(OC(C)=O)[C@H](C)[C@H]1OC(C)=O)[C@@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
288287ML00006449O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(Oc5c(C(=O)O)cc(O)c(O)c5O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]2C1=CC(=O)[C@](O)(O3)C2(O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
289288ML00008165C/C=C1\CC(C)C(O)C(=O)OCC2=CCN3CCC(OC1=O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
290289ML00006838CC(=O)O[C@H]1/C=C\[C@H](C)[C@H](/C=C/[C@H](C)C/C=C/[C@@H](C)O)OC(=O)C[C@H](O)CC[C@]1(C)Ostandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00006838_numbered.png2026-03-19 06:54:47.971059
291290ML00008200C[C@H]1CC[C@H](O)[C@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success4.0[3, 6, 7, 9]ring_size_12/standard/numbered/ML00008200_numbered.png2026-03-19 06:54:48.004777
292291ML00000748CHEMBL1242564PLA DCC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@](C)(O)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)CC[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00000748_numbered.png2026-03-19 06:54:48.046346
293292ML00001824CHEMBL2407403C[C@H]1CCC/C=C/[C@H]2CC[C@H](O)[C@@H](CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
294293ML00004058O=C1O[C@@H]2[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](OC(=O)c3cc(O)c(O)c(O)c3)O[C@H](COC(=O)c3cc(O)c(O)c4c3[C@H]3C1=CC(=O)[C@@](O)(O4)C3(O)O)[C@H]2OC(=O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
295294ML00010846CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010846_numbered.png2026-03-19 06:54:48.106749
296295ML00008645C/C=C1\C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
297296ML00008481C/C=C1\C[C@H](C)[C@@](C)(OC(C)=O)C(=O)OCc2ccn3c2[C@@H](CC3=O)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
298297ML00007869C=C1C[C@@]2(O[C@H]2C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
299298ML00007035C=C1NC(=O)[C@@H](CCCc2ccc(O)cc2)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C)NC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
300299ML00008445CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)NCCOC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
301300ML00010482CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)/C=C\[C@@](C)(O)[C@H](OC(C)=O)/C=C\[C@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010482_numbered.png2026-03-19 06:54:48.183720
302301ML00007377CC[C@H]1O[C@H]1[C@H](O)[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00007377_numbered.png2026-03-19 06:54:48.227958
303302ML00009168CCC[C@H](O)[C@@H](C)C(=O)NC/C=C\C[C@@H](C)[C@@H](O)[C@H](C)[C@@H]1C/C=C\C[C@H](C)[C@H](O)Cc2cc(OC)cc(O)c2C(=O)O1standard_macrolactone12.0success3.0[3, 8, 9]ring_size_12/standard/numbered/ML00009168_numbered.png2026-03-19 06:54:48.260155
304303ML00010279CC(O)CCCCC(C)C1CC(O)C(C)C(=O)N[C@H](Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
305304ML00006414O=C(O[C@H]1[C@@H]2OC(=O)[C@]34CC(=O)[C@](O)(O[C@@]35C(=O)O[C@@H]3[C@H](O)CO[C@]35O)[C@]3(O)Oc5c(O)c(O)cc(c5[C@H]43)C(=O)O[C@H]1[C@H]1OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC[C@H]2O1)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
306305ML00010292C[C@H]1COC(=O)[C@@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
307306ML00008765C[C@@H]1[C@@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC(=O)[C@@]1(C)O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
308307ML00009153O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(Oc4c(C(=O)O)cc(O)c(O)c4O)c(O)c3O)C(=O)O[C@H]([C@@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
309308ML00010235CC[C@H](O)[C@](C)(O)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010235_numbered.png2026-03-19 06:54:48.343892
310309ML00008518O=C(C[C@H]1C/C=C\CCC(=O)O[C@@H](c2ccccc2)CNC1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
311310ML00008019C[C@H]1CCC/C=C/C(=O)c2c(O)c(Cl)c(O)c(Cl)c2CC(=O)O1standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00008019_numbered.png2026-03-19 06:54:48.377969
312311ML00006976COC(=O)[C@@H]1CSCc2cccc(C)c2C(=O)OCC(NC(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
313312ML00007271Cc1c(O)cc(O)c2c1C(=O)OCC(NC(=O)[C@@H]1C(O)CCC1C(=O)[C@@H](N)CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)O)CSC2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
314313ML00002637CC[C@H]1CCCC(O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002637_numbered.png2026-03-19 06:54:48.432939
315314ML00006651CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1Cstandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00006651_numbered.png2026-03-19 06:54:48.481530
316315ML00007536CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)Ostandard_macrolactone12.0success8.0[3, 4, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007536_numbered.png2026-03-19 06:54:48.534566
317316ML00010840CCC(O)C(C)C1OC1CC(C)(O)/C=C/C=C(/C)C1OC(=O)CC(O)CCC(C)(O)C(OC(C)=O)/C=C\C1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010840_numbered.png2026-03-19 06:54:48.577795
318317ML00008060C[C@@H]1CCCCC[C@H](O)[C@H](O)/C=C\C(=O)O1standard_macrolactone12.0success3.0[3, 9, 10]ring_size_12/standard/numbered/ML00008060_numbered.png2026-03-19 06:54:48.609199
319318ML00010538CO[C@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@H](C)O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1ccc(Cl)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
320319ML00010683CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
321320ML00007072C=C1NC(=O)[C@@H](CCCc2ccccc2)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C)NC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
322321ML00008714C[C@H]1CCC[C@@H]2SC[C@](O)(C(=O)O)[C@H]2C(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00008714_numbered.png2026-03-19 06:54:48.660475
323322ML00008049C[C@@H]1CCC[C@H](O)C/C=C\[C@@H](O)CC(=O)O1standard_macrolactone12.0success3.0[3, 7, 11]ring_size_12/standard/numbered/ML00008049_numbered.png2026-03-19 06:54:48.691447
324323ML00000895CHEMBL1240973CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(=O)NCCOCCOCCNC(=O)CCCCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)CC[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00000895_numbered.png2026-03-19 06:54:48.740567
325324ML00008741CCCCCCC[C@H]1/C=C\CCCCCCCC(=O)O1standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00008741_numbered.png2026-03-19 06:54:48.765351
326325ML00009666CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
327326ML00004016O=C1O[C@@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@@H](O3)[C@@H](OC(=O)c3cc(O)c(O)c4c3[C@H]3C1=CC(=O)[C@@](O)(O4)C3(O)O)[C@H]2OC(=O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
328327ML00008112CO[C@@H]1CC(=O)/C=C\C[C@@H](C)OC(=O)C[C@H](O)C1standard_macrolactone12.0success4.0[3, 7, 9, 11]ring_size_12/standard/numbered/ML00008112_numbered.png2026-03-19 06:54:48.830770
329328ML00001204CHEMBL1728519CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N[C@H](C(C)(C)C)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
330329ML00009499O=C1N[C@@H](Cc2c[nH]c3ccccc23)COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
331330ML00004066O=C(O)C[C@@H]1C(=O)O[C@H]2[C@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]2[C@@H](OC(=O)c2cc(O)c(O)c4c2[C@@H]1[C@H](O)C(=O)O4)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
332331ML00010327CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)/C=C\[C@@](C)(O)[C@H](O)/C=C\[C@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010327_numbered.png2026-03-19 06:54:48.902927
333332ML00008071C[C@@H]1C/C=C\[C@@H](O)C/C=C\[C@@H](O)CC(=O)O1standard_macrolactone12.0success3.0[3, 7, 11]ring_size_12/standard/numbered/ML00008071_numbered.png2026-03-19 06:54:48.933451
334333ML00007460CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)NC[C@@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
335334ML00003885CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@](C)(O)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(=O)N2CCN(C3CCCCCC3)CC2)/C=C/[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00003885_numbered.png2026-03-19 06:54:48.982711
336335ML00007476C/C(=C/C(C)C(=O)CC(O)CC1CC(=O)NC(=O)C1)C1OC(=O)/C=C\CC/C=C\C=C/C1Cstandard_macrolactone12.0success2.0[3, 4]ring_size_12/standard/numbered/ML00007476_numbered.png2026-03-19 06:54:49.015934
337336ML00008460C/C=C1/C[C@@H](C)[C@@](C)(OC(C)=O)C(=O)OC[C@H]2[C@H](O)C[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
338337ML00007485COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OCC(NC(=O)[C@@H]2C(O)CCN2C(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
339338ML00003239C=C1C[C@@]23OC(=O)C/C=C\[C@H]4[C@H]5[C@H](/C=C/CC)[C@H]5[C@H](c5ccc(OC)c(OC)c5)[C@@H]4C(=O)OC[C@]2(C)[C@H]3[C@@H]2C=C(CO)C[C@@H]3C(=O)C(C)=C[C@H]3[C@@]12Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
340339ML00010784CC[C@H](O)[C@H](C)[C@H](O)[C@H](O)C[C@H](C)CC/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010784_numbered.png2026-03-19 06:54:49.091839
341340ML00007949C=C1C/C(=C\C)C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
342341ML00001689CHEMBL2152381O=C(C[C@@H]1C/C=C/CCC(=O)N[C@H](c2ccc(Cl)cn2)COC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
343342ML00009398COc1cc2cc(c1Cl)N1CC(=O)[C@](C)(O)C(=O)N(C)[C@H](C)C(=O)O[C@@H](CC1=O)[C@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C\C=C(\C)[C@H]2OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
344343ML00007803CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@@H](C)C[C@@H](C)C(=O)/C=C/[C@H]1Cstandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007803_numbered.png2026-03-19 06:54:49.162529
345344ML00008079C[C@@H]1C/C=C\C(=O)C/C=C\[C@@H](O)CC(=O)O1standard_macrolactone12.0success3.0[3, 7, 11]ring_size_12/standard/numbered/ML00008079_numbered.png2026-03-19 06:54:49.191278
346345ML00007147CO[C@H]1/C=C\CC/C=C\C(=O)O[C@@H](/C(C)=C/[C@H](C)C(=O)CCCC2CC(=O)NC(=O)C2)[C@@H](C)[C@@H]1Ostandard_macrolactone12.0success4.0[3, 4, 5, 6]ring_size_12/standard/numbered/ML00007147_numbered.png2026-03-19 06:54:49.225446
347346ML00001900CHEMBL1593232CO[C@H]1COC(=O)[C@@H](C)COC(=O)[C@@H](OCc2ccccc2)/C=C\[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
348347ML00006754CN[C@H]1C[C@H](C)O[C@H](O[C@H]2[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@@H](C)[C@@H]([C@@H](C)O)OC(=O)[C@@H]2C)[C@@H]1Ostandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00006754_numbered.png2026-03-19 06:54:49.275871
349348ML00004063O=C(O)/C=C1/C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1[C@@H](O)C(=O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
350349ML00006879CC(=O)O[C@@]1(C)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC(=O)[C@@](O)([C@@H](C)Cl)C[C@H]1C)[C@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
351350ML00002277C/C1=C/C[C@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)OC(=O)CCC[C@H](OC(=O)/C=C/C(C)=C/C(C)=C/C(C)=C/C[C@@H](O)C[C@H](C)O)[C@@H](C)C1standard_macrolactone12.0success4.0[3, 6, 8, 9]ring_size_12/standard/numbered/ML00002277_numbered.png2026-03-19 06:54:49.325502
352351ML00009874COc1cc2cc(c1Cl)N1CC(O)C(C)(O)C(=O)NC(C)C(=O)O[C@@H](CC1=O)[C@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C/C=C(\C)C2OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
353352ML00001747CHEMBL2152361C[C@H]1C/C=C/C[C@@H](CC(=O)NCc2ccc(Cl)cc2)C(=O)OC[C@@H](c2ccccc2)NC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
354353ML00008593C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
355354ML00010106CCC(=O)[C@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)/C=C\[C@@](C)(O)[C@H](OC(C)=O)/C=C\[C@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010106_numbered.png2026-03-19 06:54:49.387353
356355ML00007475C/C(=C\[C@H](C)C(=O)/C=C/CC1CC(=O)NC(=O)C1)[C@H]1OC(=O)/C=C\CC/C=C\[C@H](O)[C@@H](O)[C@@H]1Cstandard_macrolactone12.0success4.0[3, 4, 5, 6]ring_size_12/standard/numbered/ML00007475_numbered.png2026-03-19 06:54:49.420651
357356ML00010803O=C1OC[C@H]2CCCN2C(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@H]1Cc1ccc(F)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
358357ML00007167CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NCCOC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
359358ML00002102CHEMBL2420697CC[C@H](OC)[C@@H](C)[C@H]1O[C@@H]1[C@@H](O)[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00002102_numbered.png2026-03-19 06:54:49.474208
360359ML00006603CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)N2CCC[C@@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
361360ML00009157O=C(OC1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC(C1O)C2OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
362361ML00007527CC1CC(N(C)C)C(O)C(OC2C(C)CC(C)C(=O)/C=C/C(C)C(C(C)O)OC(=O)C2C)O1standard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007527_numbered.png2026-03-19 06:54:49.530988
363362ML00008650C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3([O-])CC[C@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
364363ML00008656C=C1C/C(=C/C)C(=O)O[C@@H]2CCN3C[C@@H](O)[C@H](COC(=O)[C@@]1(C)O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
365364ML00000093CHEMBL2418196DEMETHOXYDEBROMOAPLYSIATOXINC[C@@H](CCCc1cccc(O)c1)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@@H](C)O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
366365ML00001774CHEMBL2152357O=C(C[C@@H]1C/C=C/CCC(=O)N[C@H](c2ccccc2)COC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
367366ML00008928O=C1N[C@@H](Cc2ccccc2)COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
368367ML00003052CO[C@@H]1[C@@H](OC[C@H](C)[C@H]2OC(=O)[C@H](C)[C@@H](O[C@@H]3C[C@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](C)[C@H]3O[C@@](O)([C@H](C)[C@@H](OC(=O)[C@H](O)C(C)C)[C@H]2C)[C@@](C)(O)C[C@@H]3C)O[C@@H](C)[C@@H](O)[C@@H]1OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
369368ML00003939O=C(O[C@@H]1O[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]3[C@@H]2OC(=O)c2cc(O)c(O)c4oc5c(O)c(O)cc(c5c24)C(=O)O[C@@H]13)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
370369ML00007165CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NCCOC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
371370ML00003372O=C(N[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=O)OCC1c2ccccc2-c2ccccc21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
372371ML00007096C[C@@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
373372ML00008425C/C=C1\C[C@@H](C)[C@@](C)(OC(C)=O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
374373ML00006868CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@](O)([C@H](C)Cl)C[C@H]1C)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
375374ML00010073CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
376375ML00007023C[C@H]1CCCCCC(=O)c2c(cc(O)cc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)CC(=O)O1standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00007023_numbered.png2026-03-19 06:54:49.649136
377376ML00004041O=C1C=C2C(=O)O[C@H]3[C@@H]4OC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)OC[C@H]3O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]4OC(=O)c3cc(O)c(O)c(O)c3[C@@H]2C(=O)C1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
378377ML00004027O=C1O[C@H]2[C@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H](OC(=O)c3cc(O)c(O)c4c3[C@@H]3C1=CC(=O)C(O)(O)[C@]3(O)O4)[C@@H]1OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC[C@H]2O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
379378ML00008495O=C1OC[C@H]2O[C@H](O)[C@H](O)[C@@H](OC(=O)c3cc(O)c(O)c(O)c3-c3c1cc(O)c(O)c3O)[C@@H]2Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
380379ML00009152O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(Oc4c(C(=O)O)cc(O)c(O)c4O)c3O)C(=O)O[C@H]([C@@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
381380ML00008160CO[C@H]1CCC[C@@H](C)OC(=O)c2c(O)cc(O)cc2CC(=O)C1standard_macrolactone12.0success3.0[3, 7, 9]ring_size_12/standard/numbered/ML00008160_numbered.png2026-03-19 06:54:49.713119
382381ML00001722CHEMBL288741CCCC[C@H]1OC(=O)C[C@H](O)[C@H](Cc2ccccc2)N(C)C(=O)COC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
383382ML00009179CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](C)(O)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
384383ML00009135O=C(Oc1c(O)cc2c(c1O)-c1c(cc(O)c(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](O)[C@@H](OC2=O)[C@@H]1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
385384ML00007544CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1Cstandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007544_numbered.png2026-03-19 06:54:49.776700
386385ML00010515C=C[C@H]1[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OCC[C@@H]3C(=CO[C@@H](O[C@H]4O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]4O)[C@@H]3C=C)C(=O)OCC[C@H]21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
387386ML00007379CC(=O)O[C@H]1/C=C\[C@H](C)[C@H](/C(C)=C/C=C/[C@H](C)C[C@H]2O[C@H]2[C@H](C)O)OC(=O)C[C@H](O)CC[C@]1(C)Ostandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00007379_numbered.png2026-03-19 06:54:49.824386
388387ML00007173CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)N[C@H](Cc2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
389388ML00007429CC(C)[C@@H]1OC(=O)[C@H](C)[C@H](O)[C@H](Cc2cccnc2)NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
390389ML00001830CHEMBL1077980COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\OC2=Ostandard_macrolactone12.0success3.0[5, 6, 7]ring_size_12/standard/numbered/ML00001830_numbered.png2026-03-19 06:54:49.867743
391390ML00009902CC/C=C/[C@H]1CCC[C@H](O)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@H]4C(C)=C[C@H]3[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00009902_numbered.png2026-03-19 06:54:49.900922
392391ML00008197C[C@H]1CCC[C@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success3.0[3, 7, 9]ring_size_12/standard/numbered/ML00008197_numbered.png2026-03-19 06:54:49.930476
393392ML00006657C[C@@H]1CCCCCCCc2cc(OCc3ccccc3)cc(O)c2C(=O)O1standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00006657_numbered.png2026-03-19 06:54:49.952786
394393ML00010143O=C(N[C@H]1COC(=O)[C@@H](NC(=O)c2cccc(O)c2O)COC(=O)[C@H](NC(=O)c2cccc(O)c2O)COC1=O)c1cccc(O)c1Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
395394ML00009930CO[C@@H]1/C=C(\C)C[C@@H](/C=C/C=C/Br)OC(=O)[C@@H](C)[C@]2(O)C[C@@H](O[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]3OC)[C@H](C)[C@@H](C1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
396395ML00008317C/C=C1/C[C@H](C)[C@@](C)(CO)C(=O)OC[C@H]2CCN3CC[C@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
397396ML00008418C/C=C1/C[C@H](C)[C@](O)(CO)C(=O)OCC2=CC(=O)N3CC[C@H](OC1=O)[C@@]23OCCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
398397ML00010429C[C@H]1COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
399398ML00008647C[C@@H]1O[C@@]12C[C@@H](C)[C@@](C)(O)C(=O)OC/C1=C/CNCC[C@@H](OC2=O)C1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
400399ML00010774CCCCCCCCC[C@]1(CO)CCCC(=O)O[C@](CO)(CCCCCCCCC)CCCC(=O)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
401400ML00009154O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]([C@@H]2O)[C@H]1OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
402401ML00007831C[C@H](O)[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1Cstandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007831_numbered.png2026-03-19 06:54:50.046924
403402ML00001170CHEMBL40037CCCCCCC[C@H]1OC(=O)C[C@H](OCOC)[C@H](Cc2ccccc2)N(C)C(=O)C(C)(C)OC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
404403ML00006872C=C[C@]1(C(C)=O)C(=O)O[C@@H]2CC[N+]3(C)CC=C(COC(=O)[C@@](C)(O)[C@@H](C)[C@H]1O)[C@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
405404ML00008467C/C=C1\C[C@@H](C)[C@@](C)(OC(C)=O)C(=O)OCc2ccn3c2[C@H](CC3=O)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
406405ML00007303O=C1NCCOC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
407406ML00008324C[C@@H]1C[C@]2(C)CC(=O)O[C@@H]3CC[N+]4(CCl)CC=C(COC(=O)[C@@]1(C)O2)[C@H]34non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
408407ML00001825CHEMBL2407404C[C@H]1CCC/C=C/[C@H]2CC[C@H](O)[C@H](CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
409408ML00008610C/C=C1\C[C@H](C)[C@@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
410409ML00007356CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)CCCCCC/C=C/[C@@H]1Cstandard_macrolactone12.0success2.0[3, 4]ring_size_12/standard/numbered/ML00007356_numbered.png2026-03-19 06:54:50.118017
411410ML00010079CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
412411ML00006677CO/N=C/C=C\C(=O)NC/C=C/[C@@H]1OC(=O)c2c(O)cccc2/C=C\C=C/C=C\[C@@H]1Ostandard_macrolactone12.0success2.0[3, 4]ring_size_12/standard/numbered/ML00006677_numbered.png2026-03-19 06:54:50.151641
413412ML00005027O=C(O[C@H]1[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC[C@@H]2O[C@@H]1OC(=O)c1cc(O)c(O)c(O)c1Oc1cc2c(c(O)c1O)-c1c(cc(O)c(O)c1O)C(=O)O[C@H]1[C@@H](O)[C@H](COC2=O)O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
414413ML00007951C=C1C/C(=C\C)C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
415414ML00008059C[C@@H]1CCCCC[C@H](O)[C@@H](O)/C=C\C(=O)O1standard_macrolactone12.0success3.0[3, 9, 10]ring_size_12/standard/numbered/ML00008059_numbered.png2026-03-19 06:54:50.198776
416415ML00009875COc1cc2cc(c1Cl)N1CC[C@](C)(O)C(=O)N[C@@H](C)C(=O)O[C@H](CC1=O)[C@@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C\C=C(\C)[C@@H]2OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
417416ML00008188C[C@H]1CCC[C@@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success3.0[3, 7, 9]ring_size_12/standard/numbered/ML00008188_numbered.png2026-03-19 06:54:50.236526
418417ML00011002CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N[C@H](C(C)(C)C)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
419418ML00010311CC[C@H](OC)[C@@H](C)[C@H]1O[C@@H]1[C@@H](O)[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)CCCCCC/C=C/[C@@H]1Cstandard_macrolactone12.0success2.0[3, 4]ring_size_12/standard/numbered/ML00010311_numbered.png2026-03-19 06:54:50.271125
420419ML00004012O=C1O[C@@H]2[C@H](OC(=O)c3cc(O)c(O)c(O)c3)O[C@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@@H]2[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]2C1=CC(=O)[C@](O)(O3)C2(O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
421420ML00008056C[C@@H]1CCC[C@@H](O)C/C=C\[C@@H](O)CC(=O)O1standard_macrolactone12.0success3.0[3, 7, 11]ring_size_12/standard/numbered/ML00008056_numbered.png2026-03-19 06:54:50.309822
422421ML00007275CCC(C)C1OC(=O)C(NC(=O)c2cccc(NC=O)c2O)C(C)OC(=O)C(C)C(=O)C(CC(C)C)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
423422ML00009503COC(=O)Cc1c(C(=O)O[C@H]2[C@H](OC(=O)c3cc(O)c(O)c(O)c3)O[C@@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]2[C@@H]3O)cc(O)c(O)c1Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
424423ML00010798O=C(C[C@@H]1C/C=C\C[C@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
425424ML00007840C/C=C1/C[C@]2(CO)O[C@@]2(C)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
426425ML00007790COc1cc(O)cc2c1C(=O)O[C@@H](C)C[C@H](O)CCCCC2standard_macrolactone12.0success2.0[3, 5]ring_size_12/standard/numbered/ML00007790_numbered.png2026-03-19 06:54:50.362050
427426ML00004065O=C(O)C[C@@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1[C@@H](O)C(=O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
428427ML00008027C[C@@H]1CCC/C=C\C(=O)Cc2cc(O)cc(O)c2C(=O)O1standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00008027_numbered.png2026-03-19 06:54:50.398235
429428ML00001638CHEMBL4073900CCCCCC/C=C\CC(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CO)[C@@H](O)CC(=O)N[C@H](C(=O)N[C@@H]1/C=C/C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)OC1)C(C)C)C(C)Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
430429ML00001937CHEMBL1484157CC(C)(C)[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
431430ML00003324C[C@H]1OC(=O)[C@@H](NC(=O)CNC(=O)c2cccc(O)c2O)[C@@H](C)OC(=O)[C@@H](NC(=O)CNC(=O)c2cccc(O)c2O)[C@@H](C)OC(=O)[C@H]1NC(=O)CNC(=O)c1cccc(O)c1Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
432431ML00010800O=C(C[C@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
433432ML00009155O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@H]1OC(=O)c1cc(O)c(O)c(O)c1)[C@@H]2O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
434433ML00003597C=C(C#N)CO[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]3[C@@H]2OC(=O)C2=CC(=O)[C@]4(O)Oc5c(O)c(O)cc(c5[C@H]2C4(O)O)C(=O)O[C@H]31non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
435434ML00008280C=C1C[C@H](CC)C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@@]1(C)O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
436435ML00006798COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OCC(NC(=O)[C@@H](CO)NC(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
437436ML00008013C[C@H]1CCC/C=C\C(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00008013_numbered.png2026-03-19 06:54:50.490933
438437ML00006719CN1CCN(C(=O)C[C@@H]2C/C=C/CCC(=O)O[C@H](c3ccccc3)CNC2=O)CC1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
439438ML00009148O=C(O[C@H]([C@@H](OC(=O)c1cc(O)c(O)c(O)c1)C(=O)O)[C@@H]1OC(=O)c2cc(O)c(O)c(O)c2-c2cc(c(O)c(O)c2O)C(=O)OC[C@@H]1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
440439ML00002472CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](C)(O[C@@H]4O[C@@H](C)[C@@H](O)[C@@](C)(O)[C@H]4OC)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
441440ML00001124CHEMBL1699081O=C1N[C@@H](c2ccccc2)COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
442441ML00008652C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3([O-])CC[C@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
443442ML00008286C/C=C1\CC(C)C(C)(O)C(=O)OC/C2=C/CN(C)CCC(OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
444443ML00008622C[C@H]1O[C@@]12C[C@@H](C)[C@@](C)(O)C(=O)OCC1=CCN3CC[C@@H](OC2=O)[C@@H]13non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
445444ML00007862C/C=C1\C[C@]2(CO2)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
446445ML00010490CC(C)(C)[C@@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
447446ML00008167C/C=C1\C[C@@H](C)[C@@H](O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
448447ML00007483Cc1c(O)cc(O)c2c1C(=O)OC[C@H](NC(=O)[C@@H]1[C@H](O)CCN1C(=O)[C@@H](N)CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)O)CSC2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
449448ML00008169COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OCCC(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
450449ML00008615C/C=C1/C[C@H](C)[C@@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
451450ML00003371O=C(C[C@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
452451ML00003129C/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C(C(=O)OC)[C@H]1CC(=O)O[C@H]1C[C@H](C)[C@H]2COC(=O)C[C@@H]3C(=CO[C@@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)/C3=C/C)C(=O)OC[C@H](C)[C@H]12non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
453452ML00007886C[C@@H]1C[C@]2(C)CC(=O)O[C@@H]3CCN4CC=C(COC(=O)[C@@]1(C)O2)[C@H]34non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
454453ML00010665CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](c2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
455454ML00007293CC(C)N[C@H]1C/C=C/C[C@@H](CC(=O)NCc2ccc(Cl)cc2)C(=O)NC[C@@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
456455ML00008070C[C@@H]1CCCCC[C@H](O)C(=O)/C=C\C(=O)O1standard_macrolactone12.0success3.0[3, 9, 10]ring_size_12/standard/numbered/ML00008070_numbered.png2026-03-19 06:54:50.658197
457456ML00002808CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](C6CCC6)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002808_numbered.png2026-03-19 06:54:50.695834
458457ML00004031O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]2C1=CC(=O)[C@@H](O3)C2(O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
459458ML00004061O=C(O)C[C@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]1[C@H](O)C(=O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
460459ML00006794CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N[C@H](C(C)(C)C)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
461460ML00000982CHEMBL2381164CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4c(Br)cc(Br)c(O)c4Br)O[C@@]1(C3)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
462461ML00006111CCCCCC/C=C\CC(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CO)[C@@H](O)CC(=O)N[C@H](C(=O)N[C@@H]1/C=C\C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)OC1)C(C)C)C(C)Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
463462ML00007478C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\C=C/[C@@H]1Cstandard_macrolactone12.0success2.0[3, 4]ring_size_12/standard/numbered/ML00007478_numbered.png2026-03-19 06:54:50.766825
464463ML00010630CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
465464ML00006980C=C/C1=C/[C@@H](C)[C@](C)(OC(C)=O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
466465ML00008462CC[C@@]1(O)C[C@@H](C)[C@](C)(OC(C)=O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
467466ML00008272C[C@@H]1C[C@@]2(O[C@@H]2C)C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@@]1(C)O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
468467ML00009053CO[C@@H]1[C@H](O[C@H]2C[C@@]3(O)CC(=O)O[C@@H](/C=C/C=C/C#C[C@H]4C[C@@H]4Cl)C/C(C)=C\[C@@H](OC)[C@@H](C)[C@H](O3)[C@@H]2C)O[C@H](C)[C@H](NC=O)[C@]1(C)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
469468ML00007884C[C@@H]1C[C@@]2(C)CC(=O)O[C@@H]3CCN4CC=C(COC(=O)[C@]1(C)O2)[C@H]34non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
470469ML00007337CC[C@H](C)[C@H]1OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC(=O)C(C)(C)C(=O)[C@@H](CC(C)C)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
471470ML00008384CC1CCCC(SCC(O)C(=O)O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success3.0[3, 7, 9]ring_size_12/standard/numbered/ML00008384_numbered.png2026-03-19 06:54:50.850304
472471ML00007914C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OCc2ccn3c2[C@H](CC3=O)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
473472ML00004045O=C1C=C2C(=O)O[C@H]3[C@@H]4OC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)OC[C@H]3O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]4OC(=O)c3cc(O)c(O)c(O)c3[C@H]2[C@@H](C(=O)O)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
474473ML00006697CO[C@@H]1[C@@H](CO)O[C@@H](Oc2cc(O)cc3c2C(=O)CCCCC[C@H](C)OC(=O)C3)[C@H](O)[C@H]1Ostandard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00006697_numbered.png2026-03-19 06:54:50.895612
475474ML00007633CCC(C)C1OC(=O)[C@@H](NC(=O)c2cccc(N)c2O)[C@H](C)OC(=O)C(C)(C)OC(CC(C)C)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
476475ML00008639C=C1C/C(=C/C)C(=O)O[C@@H]2CCN3C[C@@H](O)[C@H](COC(=O)[C@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
477476ML00010098CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
478477ML00010833CC[C@H](O)[C@@H](C)[C@H]1O[C@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010833_numbered.png2026-03-19 06:54:50.962929
479478ML00007996C[C@H]1CCC/C=C\[C@H]2CC[C@H](O)[C@H](CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
480479ML00008075C[C@@H]1CCCCCCC(=O)/C=C\C(=O)O1standard_macrolactone12.0success2.0[3, 10]ring_size_12/standard/numbered/ML00008075_numbered.png2026-03-19 06:54:50.994739
481480ML00008598C/C=C1\C[C@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
482481ML00010492CC(C)(C)[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
483482ML00008660C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3C[C@@H](O)[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
484483ML00007916CSC1=NC2c3ccccc3SCCCCCOC(=O)C2C(C)=N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
485484ML00005754CC(=C/C(C)=C/C=C/C(C)=C/[C@H](O)[C@H](O)C[C@H](C)O)/C=C/C(=O)O[C@H]1CCCC(=O)O[C@H]([C@@H](C)C/C(C)=C/[C@H](C)[C@@H](O)C[C@H](C)O)C/C=C(/C)C[C@@H]1Cstandard_macrolactone12.0success4.0[3, 6, 8, 9]ring_size_12/standard/numbered/ML00005754_numbered.png2026-03-19 06:54:51.059888
486485ML00006781CC(C)C[C@@H]1NC(=O)C[C@H]2[C@@H]3OC(C)(C)O[C@H]3c3cc4c(cc3N2C/C=C\COC1=O)OCO4non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
487486ML00008515COC(=O)[C@@H]1CSCc2c(O)cc(O)cc2C(=O)OCC(NC(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
488487ML00008489C=C1C/C(=C/C)C(=O)O[C@@H]2CC(=O)n3ccc(c32)COC(=O)[C@@]1(C)OC(C)=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
489488ML00004032O=C(O[C@@H]1COC(=O)c2cc(c(O)c(O)c2O)-c2c(cc(O)c(O)c2O)C(=O)O[C@H]1[C@@H]1OC(=O)c2cc(O)c(O)c(O)c2-c2c(O)c(O)c(O)c3c2C(=O)O[C@@H]1[C@H]3O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
490489ML00001176CHEMBL3259831C/C=C\c1nc(CC/C=C\C(=O)O[C@@H]2C[C@H]3/C=C(/C)C[C@H](OC)C[C@H](CCC)OC(=O)C[C@@H](C2)O3)co1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
491490ML00004022O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]2C1=CC(=O)C(O)(O)[C@]2(O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
492491ML00008661C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3C[C@H](O)[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
493492ML00001060CHEMBL1078175COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C(F)=C/OC2=Ostandard_macrolactone12.0success4.0[4, 5, 6, 7]ring_size_12/standard/numbered/ML00001060_numbered.png2026-03-19 06:54:51.148279
494493ML00001704CHEMBL2152370O=C(C[C@@H]1C/C=C/CCC(=O)O[C@H](c2ccccc2)CNC1=O)NCCCC(F)(F)Fnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
495494ML00008193C[C@@H]1CCC[C@@H](O)CC(=O)Cc2cc(O)cc(O)c2C(=O)O1standard_macrolactone12.0success3.0[3, 7, 9]ring_size_12/standard/numbered/ML00008193_numbered.png2026-03-19 06:54:51.183700
496495ML00000108CHEMBL2148107C[C@@H]1CC(C)(C)[C@@]23C[C@@H](C[C@@H](CCCCc4cccc(O)c4)O2)OC(=O)C[C@H](CO)OC(=O)C[C@@H]1O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
497496ML00007406C[C@H]1C/C=C/Cc2cccc(O)c2C(=O)O[C@@H](C/C=C/NC(=O)C#Cc2ccccc2)C[C@H]1Ostandard_macrolactone12.0success3.0[3, 5, 6]ring_size_12/standard/numbered/ML00007406_numbered.png2026-03-19 06:54:51.220005
498497ML00001910CHEMBL2420608CC[C@H](OC)[C@@H](C)[C@H]1O[C@@H]1[C@H](OC(C)=O)[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00001910_numbered.png2026-03-19 06:54:51.260995
499498ML00007545CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1Cstandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007545_numbered.png2026-03-19 06:54:51.305107
500499ML00010416C[C@H]1COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
501500ML00002793CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)[C@@H](O)[C@H]4C=C[C@H]3[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002793_numbered.png2026-03-19 06:54:51.346900
502501ML00007858C=C1C/C(=C/C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@@]1(O)CO)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
503502ML00008078C[C@@H]1OC(=O)/C=C\[C@H](O)[C@H](C)OC(=O)/C=C\[C@@H]1Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
504503ML00008354COc1cc(O)c2c(c1C)C(=O)O[C@H](CO)C/C(S)=N/[C@H](c1nc(C)no1)CSC2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
505504ML00009136O=C1NC[C@@H](c2ccccc2)OC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
506505ML00007950C=C1C/C(=C\C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
507506ML00006888C/C=C1\C[C@@H](C)[C@](C)(OC(C)=O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
508507ML00004044O=C1C[C@H]2C(=O)O[C@H]3[C@@H]4OC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)OC[C@H]3O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]4OC(=O)c3cc(O)c(O)c(O)c3C2=C(C(=O)O)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
509508ML00004068O=C(O)CC1C(=O)OC2C3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC2C(OC(=O)c2cc(O)c(O)c4c2C1C(O)C(=O)O4)C(OC(=O)c1cc(O)c(O)c(O)c1)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
510509ML00001745CHEMBL2152355C[C@H]1NC(=O)[C@H](CC(=O)NCc2ccc(Cl)cc2)C/C=C/CCC(=O)O[C@@H]1c1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
511510ML00004291CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H](O[C@@H]4O[C@@H](C)[C@H](O)[C@@](C)(O)[C@H]4O)[C@@](C)(O)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
512511ML00003373O=C(N[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@@H]2COC1=O)OCC1c2ccccc2-c2ccccc21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
513512ML00009104O=C1O[C@H]2[C@H](O)[C@@H](OC(=O)c3cc(O)c(O)c4c3[C@@H]3C1=CC(=O)[C@](O)(O4)C3(O)O)[C@@H]1OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC[C@H]2O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
514513ML00007164CC[C@H](C)[C@H]1OC(=O)[C@@H](NC(=O)c2cccc(N)c2O)[C@@H](C)OC(=O)C(C)(C)C(=O)[C@@H](CC(C)C)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
515514ML00010698CC/C=C/C=C/CC[C@]1(C)C[C@H](O)[C@H](C)CC[C@H]2C[C@@H](C[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]3OC)C[C@@](O)(CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
516515ML00007887C=C1C/C(=C\C)C(=O)O[C@@H]2CCN3CC[C@H](COC(=O)[C@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
517516ML00001746CHEMBL2152354C[C@@H]1NC(=O)[C@H](CC(=O)NCc2ccc(Cl)cc2)C/C=C/CCC(=O)O[C@@H]1c1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
518517ML00010070CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
519518ML00002381CCC[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002381_numbered.png2026-03-19 06:54:51.511745
520519ML00007044CCCOc1cc2c(c(OCCC)c1)C(=O)O[C@H](C)CCCCCCC2standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00007044_numbered.png2026-03-19 06:54:51.535467
521520ML00006386O=C(OC1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC3C2OC(=O)[C@@]24CC(=O)[C@@](O)(OC25C(=O)O[C@H]2[C@@H](O)CO[C@@]25O)C2(O)Oc5c(O)c(O)cc(c5C24)C(=O)OC13)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
522521ML00004029O=C1OC[C@@H](O)[C@H]([C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)c4c3C(=O)O[C@@H]2[C@@H]4O)OC(=O)c2cc(O)c(O)c(O)c2-c2cc1c(O)c(Oc1c(C(=O)O)cc(O)c(O)c1O)c2Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
523522ML00003940O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]3[C@H]1OC(=O)c1cc(O)c(O)c4oc5c(O)c(O)cc(c5c14)C(=O)O[C@@H]32)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
524523ML00008050C[C@H]1CCCCCC/C=C\CC(=O)O1standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00008050_numbered.png2026-03-19 06:54:51.587907
525524ML00008318C[C@@H]1C[C@](O)([C@@H](C)Cl)C(=O)O[C@@H]2CC[N+]3(C)CC=C(COC(=O)[C@]1(C)O)[C@@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
526525ML00007435CC/C=C\C=C/C(=O)N/C=C/C[C@H]1C[C@H](O)[C@H](C)C/C=C\Cc2cccc(O)c2C(=O)O1standard_macrolactone12.0success3.0[3, 5, 6]ring_size_12/standard/numbered/ML00007435_numbered.png2026-03-19 06:54:51.627109
527526ML00010496CCCCCCC[C@H]1OC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)OC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
528527ML00008556COc1cc(O)cc2c1C(=O)OC(C)(C)CCCCCCC2standard_macrolactone12.0success2.0[3, 3]ring_size_12/standard/numbered/ML00008556_numbered.png2026-03-19 06:54:51.661742
529528ML00008014C[C@H]1CCC(=O)[C@H]2CC(=O)c3c(cc(O)cc3O2)CC(=O)O1non_standard_macrocycle12.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
530529ML00006943COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OCC(NC(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
531530ML00007637C/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OC[C@H](C)[C@@H]3C[C@H](OC(=O)C[C@H]21)[C@H](C)[C@H]3COnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
532531ML00000040CHEMBL1242745PLADIENOLIDE BCC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)CC[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00000040_numbered.png2026-03-19 06:54:51.725203
533532ML00007594O=C(C[C@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
534533ML00006820O=C1CC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@H]2CO1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
535534ML00004025O=C1O[C@@H]2[C@@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@@H]2[C@H](OC(=O)c2cc(O)c(O)c4c2[C@@H]2C1=CC(=O)[C@](O)(O4)C2(O)O)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
536535ML00000068CHEMBL2148106DEBROMOAPLYSIATOXINCO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@@H](C)O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cccc(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
537536ML00008216C[C@@H]1CC[C@@H](O)/C=C\C(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success3.0[3, 6, 9]ring_size_12/standard/numbered/ML00008216_numbered.png2026-03-19 06:54:51.785208
538537ML00007611CC/C(C)=C1\OC(=O)[C@H](C)[C@@H](O)[C@H](Cc2cccnc2)NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
539538ML00000644CHEMBL2407405CCO[C@H]1C=C[C@H]2C/C=C\CC[C@H](C)OC(=O)C[C@@H]1O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
540539ML00002636CCN[C@@H]1CC[C@@H](O[C@@H]2CCC[C@H](CC)OC(=O)C[C@@H]3C(=C[C@H]4[C@@H]3C=C[C@H]3C[C@@H](O[C@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@@H]5OC)C[C@@H]34)C(=O)[C@H]2C)O[C@H]1Cstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002636_numbered.png2026-03-19 06:54:51.836919
541540ML00001729CHEMBL290433COCO[C@@H]1CC(=O)O[C@H](C)[C@H](C)C(=O)O[C@@H](C(C)C)C(=O)N(C)[C@H]1Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
542541ML00007112C[C@H]1COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
543542ML00008308C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CC[N+]3(C)CC[C@@H](OC1=O)[C@@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
544543ML00008596C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
545544ML00008566C[C@H](Cl)[C@@]1(O)C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
546545ML00010302CC(=O)CCCC[C@@H](C)[C@H]1C[C@H](O)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
547546ML00008379C/C=C1\C[C@H](C)[C@@H](OC(C)=O)C(=O)OCC2=CCN3CC[C@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
548547ML00007791COc1cc(O)cc2c1C(=O)O[C@H](C)CC[C@@H](O)CCCC2standard_macrolactone12.0success2.0[3, 6]ring_size_12/standard/numbered/ML00007791_numbered.png2026-03-19 06:54:51.912705
549548ML00010491C=C[C@H]1[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OCC[C@@H]3C(=CO[C@@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H]3C=C)C(=O)OCC[C@H]21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
550549ML00004206O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@@H]1O)[C@H]2OC(=O)[C@@H]1CC(=O)c2oc(=O)c3cc(O)c(O)c(O)c3c21)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
551550ML00004018O=C1OC2C(OC(=O)c3cc(O)c(O)c(O)c3)OC3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC2C3OC(=O)c2cc(O)c(O)c3c2C2C1=CC(=O)C(O)(O3)C2(O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
552551ML00006725O=C(C[C@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
553552ML00004023O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]2C1=CC(=O)C(O)(O)[C@]2(O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
554553ML00007842C[C@@H]1OC[C@@]23C[C@]1(O)C(=O)O[C@@H]1CCN4CC=C(COC(=O)[C@@]2(C)O3)[C@H]14non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
555554ML00007795COc1cc(O)cc2c1C(=O)OC(C)C(O)CCCCCC2standard_macrolactone12.0success2.0[3, 4]ring_size_12/standard/numbered/ML00007795_numbered.png2026-03-19 06:54:51.990745
556555ML00006654C/C=C1\C(=O)OC2CCN(C)C/C=C(/COC(=O)C(C)(OC(C)=O)C(C)C1OC(C)=O)C2Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
557556ML00007166CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NCCOC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
558557ML00008581C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2[C@H](O)CN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
559558ML00007656C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\CC[C@@H]1Cstandard_macrolactone12.0success2.0[3, 4]ring_size_12/standard/numbered/ML00007656_numbered.png2026-03-19 06:54:52.040502
560559ML00009247CO[C@@H]1[C@H](O[C@H]2C[C@@]3(O)CC(=O)O[C@@H](/C=C/C=C/C#C[C@H]4C[C@@H]4Cl)C/C(C)=C\[C@@H](OC)[C@@H](C)[C@H](O3)[C@@H]2C)O[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
561560ML00007174CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)N[C@@H](Cc2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
562561ML00002400CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@@H](NC)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002400_numbered.png2026-03-19 06:54:52.093028
563562ML00009130O=C1OC[C@H](c2ccccc2)NC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@H]1Cc1ccc(F)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
564563ML00008461CC(=O)O[C@@]1(C)C(=O)OCC2=CCN3CC[C@@H](OC(=O)[C@@](O)([C@H](C)O)C[C@H]1C)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
565564ML00008284C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
566565ML00007477C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@H]1OC(=O)/C=C\CC/C=C\C=C/[C@@H]1Cstandard_macrolactone12.0success2.0[3, 4]ring_size_12/standard/numbered/ML00007477_numbered.png2026-03-19 06:54:52.142673
567566ML00001003CHEMBL1081556O=C(C[C@@H]1C/C=C/CCC(=O)O[C@@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
568567ML00008373Cc1c(O)cc(O)c2c1C(=O)OCC(NC(=O)OC(C)(C)C)C(=O)NCCSC2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
569568ML00008256C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
570569ML00002279CC(=C/C(C)=C/C[C@H](O)C[C@@H](C)O)/C=C(C)\C=C\C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1Cstandard_macrolactone12.0success4.0[3, 6, 8, 9]ring_size_12/standard/numbered/ML00002279_numbered.png2026-03-19 06:54:52.197668
571570ML00008307C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CC[N+]3(C)CC[C@@H](OC1=O)[C@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
572571ML00007774O=C(C[C@H]1C/C=C\CCC(=O)OC[C@H]2CCCN2C1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
573572ML00007094C[C@@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
574573ML00010066CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N2CCC[C@@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
575574ML00008285C/C=C1\C[C@H](C)[C@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
576575ML00001094CHEMBL1242374PLADIENOLIDE FCC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@](C)(O)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](O)CC[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00001094_numbered.png2026-03-19 06:54:52.273338
577576ML00010274CC[C@H](OC)[C@@H](C)[C@H]1O[C@@H]1[C@@H](O)[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CCCC/C=C/[C@@H]1Cstandard_macrolactone12.0success3.0[3, 4, 11]ring_size_12/standard/numbered/ML00010274_numbered.png2026-03-19 06:54:52.305997
578577ML00008288C/C=C1\CC(C)C(C)(CO)C(=O)OCC2=CCN3CCC(OC1=O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
579578ML00009143O=C(C[C@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)O[C@H](c2ccccc2)CNC1=O)N[C@@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
580579ML00007413O=C(OC1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)CC(C2O)C1O)c1cc(O)c(O)c(O)c1standard_macrolactone12.0success2.0[5, 8]ring_size_12/standard/numbered/ML00007413_numbered.png2026-03-19 06:54:52.347760
581580ML00010276C[C@@H]1COC(=O)[C@@H](CC(=O)OC(C)(C)C)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
582581ML00008362C=C1C/C(=C/C)C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@]1(C)O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
583582ML00010540CO[C@H](CC[C@@H](C)[C@@H]1O[C@@]23C[C@@H](OC(=O)C[C@@H]([C@H](C)O)OC(=O)CC(=C(C)CC2(C)C)O3)[C@H]1C)c1cccc(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
584583ML00008263C/C=C1/C[C@@H](C)[C@](O)(CO)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
585584ML00002882CCCCCC/C=C\CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H]1/C=C\C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)OC1)C(C)Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
586585ML00007888C/C=C1\CC(C)C(C)(O)C(=O)OCC2=CCN3CCC(OC1=O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
587586ML00004075O=C1OC[C@H]2O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]3OC(=O)c4cc(O)c(O)c5c4[C@@H]4C(=CC(=O)[C@](O)(O5)C4(O)O)C(=O)O[C@H]2[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]2C1=CC(=O)[C@](O)(O3)C2(O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
588587ML00000027CHEMBL1258348CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4cccc(O)c4)O[C@@]1(C3)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
589588ML00000072CHEMBL1256416APLYSIATOXINCO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@@H](C)O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cc(O)ccc1Brnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
590589ML00004015O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@@H](O3)[C@@H](OC(=O)c3cc(O)c(O)c4c3[C@H]3C1=CC(=O)[C@@](O)(O4)C3(O)O)[C@@H]2OC(=O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
591590ML00007426CC/C=C\C=C/C(=O)N/C=C/C[C@H]1C[C@@H](O)[C@@H](C)C/C=C/Cc2ccc(F)c(O)c2C(=O)O1standard_macrolactone12.0success3.0[3, 5, 6]ring_size_12/standard/numbered/ML00007426_numbered.png2026-03-19 06:54:52.447711
592591ML00008209COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OC[C@H](N)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
593592ML00010900CC[C@H](OC)[C@@H](C)[C@H]1O[C@@H]1[C@H](O)[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010900_numbered.png2026-03-19 06:54:52.495171
594593ML00002284CC(=C/C[C@H](O)C[C@@H](C)O)/C=C(C)\C=C(C)/C=C/C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1Cstandard_macrolactone12.0success4.0[3, 6, 8, 9]ring_size_12/standard/numbered/ML00002284_numbered.png2026-03-19 06:54:52.529947
595594ML00007466CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)N[C@@H](c2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
596595ML00000377CHEMBL393258LASIODIPLODINCOc1cc(O)cc2c1C(=O)O[C@@H](C)CCCCCCC2standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00000377_numbered.png2026-03-19 06:54:52.559962
597596ML00008592C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
598597ML00007982C[C@H]1CCCCC[C@@H](O)C(=O)[C@H](SCC(=O)O)CC(=O)O1standard_macrolactone12.0success4.0[3, 9, 10, 11]ring_size_12/standard/numbered/ML00007982_numbered.png2026-03-19 06:54:52.608005
599598ML00009720O=C(C[C@@H]1C/C=C\C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OCCNC1=O)N[C@@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
600599ML00008637C=C1C/C(=C\C)C(=O)O[C@@H]2CCN3C[C@@H](O)[C@H](COC(=O)[C@@]1(C)O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
601600ML00010537CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)C[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](C)(O)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
602601ML00009244CC(C)=CCOc1ccc(C[C@@H]2NC(=O)[C@H](C)[C@@H](O)C[C@H]([C@@H](C)CCCC[C@H](C)O)OC(=O)[C@@H]3CCCCN3C2=O)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
603602ML00002750CC[C@H](O)C[C@H](O)C/C=C(C)/C=C(C)/C=C(C)/C=C/C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1Cstandard_macrolactone12.0success4.0[3, 6, 8, 9]ring_size_12/standard/numbered/ML00002750_numbered.png2026-03-19 06:54:52.775747
604603ML00000351CHEMBL164363311BETA-METHOXYCURVULARINCO[C@@H]1CCC[C@H](C)OC(=O)Cc2cc(O)cc(O)c2C(=O)C1standard_macrolactone12.0success3.0[3, 7, 9]ring_size_12/standard/numbered/ML00000351_numbered.png2026-03-19 06:54:52.822515
605604ML00004048O=C(O)/C=C(\C(=O)O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@H](O)[C@@H](OC(=O)c1cc(O)c(O)c(O)c1)O2)[C@H]1c2c(cc(O)c(O)c2O)C(=O)O[C@@H]1C(=O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
606605ML00007294O=C1CC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CO1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
607606ML00000732CHEMBL1242284CCNC(=O)O[C@H]1CC[C@H](C)[C@@H](/C(C)=C/C=C/[C@@H](C)C[C@H]2O[C@@H]2[C@H](C)[C@@H](O)CC)OC(=O)C[C@H](O)CC[C@@]1(C)Ostandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00000732_numbered.png2026-03-19 06:54:52.908373
608607ML00001201CHEMBL2420603CC[C@H](OC)[C@@H](C)[C@H]1O[C@@H]1[C@H](O)[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00001201_numbered.png2026-03-19 06:54:52.959480
609608ML00004062O=C(O)C[C@@H]1C(=O)O[C@@H]2[C@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]2[C@H](OC(=O)c2cc(O)c(O)c4c2[C@H]1[C@H](O)C(=O)O4)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
610609ML00000944CHEMBL1939386EXCOECARIPHENOL DO=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c4oc5c(O)c(O)cc(c5c34)C(=O)O[C@@H]3[C@H]1OC(=O)c1cc(O)c(O)c4c1[C@@H]1[C@@]5(C[C@]6(O)OC[C@@H](O)[C@@H]6O[C@@H]5C(O)(O)C(O)(O)[C@]1(O)O4)C(=O)O[C@@H]32)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
611610ML00007844C[C@@H]1O[C@]12C[C@]1(CO1)[C@@](C)(O)C(=O)OCC1=CCN3CC[C@H](OC2=O)[C@@H]13non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
612611ML00002282CC(=C/C[C@H](O)C[C@@H](C)O)/C=C(C)/C=C(C)/C=C/C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1Cstandard_macrolactone12.0success4.0[3, 6, 8, 9]ring_size_12/standard/numbered/ML00002282_numbered.png2026-03-19 06:54:53.028658
613612ML00001576CHEMBL1731299O=C(N[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)COC1=O)OCC1c2ccccc2-c2ccccc21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
614613ML00007998C[C@@H]1CCC/C=C\[C@H]2CC[C@H](O)[C@H](CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
615614ML00007576O=C(O[C@@H]1O[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@H]2O)[C@@H]1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
616615ML00001018CHEMBL290432CCCCCCC[C@H]1OC(=O)C[C@H](O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
617616ML00010972CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H](CO)OC(=O)/C=C(\O2)[C@@](C)(O)CC3(C)C)[C@@H]1C)c1cccc(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
618617ML00010291C[C@@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
619618ML00000730CHEMBL1771487O=C1CC/C=C/CCC(=O)N(Cc2cccc(/C=N/NC(=O)c3cccc(C(=O)NO)c3)c2)C[C@H](c2ccccc2)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
620619ML00009342CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
621620ML00007025COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OCC(NC(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
622621ML00008766C[C@H]1[C@@H](C)[C@](C)(O)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(O)CO)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
623622ML00007959C[C@@H]1C[C@@H]2O[C@H](CC[C@H]2O)CC(=O)Cc2cc(O)cc(O)c2C(=O)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
624623ML00007800COc1cc(O)c2c(c1)CCCCCCC[C@@H](C)OC2=Ostandard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00007800_numbered.png2026-03-19 06:54:53.140883
625624ML00007078C=C(CC)[C@H](C)C[C@@H]1C[C@H](C)C[C@H](C)C(=O)C[C@H](O)/C(C)=C\C(=O)O1standard_macrolactone12.0success6.0[3, 5, 7, 8, 10, 11]ring_size_12/standard/numbered/ML00007078_numbered.png2026-03-19 06:54:53.187495
626625ML00007436CC/C=C\C=C/C(=O)N/C=C/C[C@H]1C[C@@H](O)[C@@H](C)C/C=C\Cc2cccc(O)c2C(=O)O1standard_macrolactone12.0success3.0[3, 5, 6]ring_size_12/standard/numbered/ML00007436_numbered.png2026-03-19 06:54:53.218800
627626ML00006809CC(C)[C@@H]1NC(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
628627ML00007855C=C1C/C(=C/C)C(=O)O[C@@H]2CC[N+]3([O-])CC=C(COC(=O)[C@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
629628ML00009560CC[C@@H](O)[C@@](C)(O)C1OC(=O)[C@@H](C)[C@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H]2O[C@@H]([C@@H]1C)[C@@H]2Cnon_standard_macrocycle12.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
630629ML00008600C/C=C1\CC(C)C(C)(O)C(=O)OCC2CCN3CCC(OC1=O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
631630ML00000985CHEMBL2381162CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4cc(O)ccc4Br)O[C@@]1(C3)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
632631ML00001156CHEMBL1242654PLADIENOLIDE ECC[C@H](O)[C@](C)(O)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)CC[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00001156_numbered.png2026-03-19 06:54:53.317169
633632ML00010112CO[C@@H]1/C=C\CC[C@H](SC[C@H](N)C(=O)O)CC(=O)O[C@@H](/C(C)=C/[C@@H](C)C(=O)C[C@H](O)CC2CC(=O)NC(=O)C2)[C@H](C)[C@@H]1Ostandard_macrolactone12.0success5.0[3, 4, 5, 6, 11]ring_size_12/standard/numbered/ML00010112_numbered.png2026-03-19 06:54:53.361583
634633ML00002074CHEMBL2152359C[C@H]1[C@@H](c2ccccc2)OC(=O)CC/C=C/C[C@@H](CC(=O)NCc2ccc(Cl)cc2)C(=O)N1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
635634ML00002999COC(=O)C[C@@]12Oc3c(O)c(O)cc(C(=O)O[C@@H]4[C@H]5COC(=O)c6cc(O)c(O)c(O)c6-c6c(cc(O)c(O)c6O)C(=O)O[C@@H]4[C@@H](O)[C@@H](OC(=O)c4cc(O)c(O)c(O)c4)O5)c3[C@@H]1[C@H](C(=O)OC)OC2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
636635ML00004072O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]([C@@H]2OC(=O)c2cc(O)c(O)c(O)c2)[C@H]1OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
637636ML00006991O=C(C[C@@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OCCNC1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
638637ML00009149O=C(O[C@@H]1[C@@H](O)[C@H](O)O[C@@H]2COC(=O)c3cc(c(O)c(O)c3O)-c3c(cc(Oc4c(C(=O)O)cc(O)c(O)c4O)c(O)c3O)C(=O)O[C@H]21)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
639638ML00008521C=C1C/C(=C/C)C(=O)OC2CCN3CC=C(COC(=O)C1(C)OC(C)=O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
640639ML00001962CHEMBL2152362O=C(C[C@@H]1C/C=C/C[C@H](Cc2ccccc2)C(=O)N[C@H](c2ccccc2)COC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
641640ML00001228CHEMBL1159466O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2C2C1=CC(=O)C(O)(O)C2(O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
642641ML00008483C=C1C(=O)O[C@@H]2CC(=O)n3ccc(c32)COC(=O)[C@](C)(OC(C)=O)[C@H](C)[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
643642ML00008083C[C@H]1CCCCC[C@H](O)C(=O)[C@H](O)CC(=O)O1standard_macrolactone12.0success4.0[3, 9, 10, 11]ring_size_12/standard/numbered/ML00008083_numbered.png2026-03-19 06:54:53.519601
644643ML00002216C=C1C[C@@]23OC(=O)C/C=C\[C@H]4[C@H]5[C@H](/C=C/CC)[C@H]5[C@H](c5ccc(OC)cc5)[C@@H]4C(=O)OC[C@]2(C)[C@H]3[C@@H]2C=C(CO)C[C@@H]3C(=O)C(C)=C[C@H]3[C@@]12Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
645644ML00008267C/C=C1\C[C@@H](C)[C@](C)(O)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC1=O)[C@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
646645ML00000848CHEMBL1436969O=C(C[C@@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@H]2CCCN2C1=O)N[C@@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
647646ML00007140CC(C)(C)[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
648647ML00008259C[C@@H]1C/C(=C\CO)C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@]1(C)O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
649648ML00008063C[C@H]1C[C@@H](O)CCCCC(=O)CCC(=O)O1standard_macrolactone12.0success3.0[3, 5, 10]ring_size_12/standard/numbered/ML00008063_numbered.png2026-03-19 06:54:53.609207
650649ML00007946C=C1C/C(=C/C)C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
651650ML00007788COc1cc(O)cc2c1C(=O)O[C@@H](C)C[C@@H](O)CCCCC2standard_macrolactone12.0success2.0[3, 5]ring_size_12/standard/numbered/ML00007788_numbered.png2026-03-19 06:54:53.649142
652651ML00001972CHEMBL2417583CC[C@H](OC)[C@@H](C)[C@H]1O[C@@H]1[C@H](OC(C)=O)[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](OC(C)=O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00001972_numbered.png2026-03-19 06:54:53.697562
653652ML00001730CHEMBL38977CCCC[C@H]1OC(=O)C[C@H](OCOC)[C@H](Cc2ccccc2)N(C)C(=O)COC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
654653ML00008669C/C=C1\CC(C)C(C)(O)C(=O)OCC2=CCN3CC(O)C(OC1=O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
655654ML00001055CHEMBL3400936C/C1=C\CCC(C)(O)C(C)OC(=O)Cc2c(Cl)c(O)cc(O)c2C1=Ostandard_macrolactone12.0success5.0[3, 4, 4, 8, 9]ring_size_12/standard/numbered/ML00001055_numbered.png2026-03-19 06:54:53.758644
656655ML00009102O=C1O[C@@H]([C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)c4c3C(=O)O[C@H]2[C@@H]4O)[C@H](O)COC(=O)c2cc(O)c(O)c(O)c2-c2cc1c(O)c(O)c2Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
657656ML00001200CHEMBL2420695CC[C@H](OC)[C@@H](C)[C@H]1O[C@@H]1[C@H](O)[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00001200_numbered.png2026-03-19 06:54:53.824950
658657ML00007111C[C@@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
659658ML00007580O=C(OC1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC(C2O)C1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
660659ML00006870COc1cc(O)c2c(c1C)C(=O)OC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](CO)CSC2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
661660ML00001865CHEMBL38248COCO[C@H]1CC(=O)O[C@H](C)[C@H](C)C(=O)OCC(=O)N(C)[C@H]1Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
662661ML00002696CCC[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@H]4C(C)=C[C@H]3[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002696_numbered.png2026-03-19 06:54:53.900438
663662ML00004011O=C(O)/C=C(\C(=O)O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@@H](O)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O2)[C@H]1c2c(cc(O)c(O)c2O)C(=O)O[C@@H]1C(=O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
664663ML00006749CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)Ostandard_macrolactone12.0success8.0[3, 4, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00006749_numbered.png2026-03-19 06:54:53.960925
665664ML00007585O=C(O[C@H]1[C@@H](O)O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]1[C@@H]2O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
666665ML00004046O=C1C=C2C(=O)O[C@H]3[C@@H]4OC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)OC[C@H]3O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]4OC(=O)c3cc(O)c(O)c(O)c3[C@H]2[C@H](C(=O)O)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
667666ML00001171CHEMBL38932CCCCCCC[C@@H]1CC(=O)O[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)[C@H](OCOC)CC(=O)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
668667ML00008642C=C1C/C(=C/C)C(=O)O[C@@H]2CC[N+]3([O-])C[C@@H](O)[C@H](COC(=O)[C@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
669668ML00008168COc1c(Br)c(O)c(Br)c2c1C(=O)OC(C)CCCCCCC2standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00008168_numbered.png2026-03-19 06:54:54.013143
670669ML00001186CHEMBL3260940CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)/C=C\CCc3coc(/C=C\CNC(=O)OC)n3)C[C@H](CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
671670ML00006703CC(=O)O[C@@H](C)[C@@]1(O)C[C@@H](C)[C@](C)(OC(C)=O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
672671ML00008404CC[C@H]1C[C@H](C)[C@](C)(OC(C)=O)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
673672ML00010181O=C1CC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)CO1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
674673ML00008026C[C@H]1CCC/C=C\C(=O)Cc2cc(O)cc(O)c2C(=O)O1standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00008026_numbered.png2026-03-19 06:54:54.065054
675674ML00010296C[C@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
676675ML00003971O=C(O)C[C@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c(O)c2[C@H]1[C@H](O)C(=O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
677676ML00009341CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
678677ML00009131O=C1N[C@@H](c2ccccc2)COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
679678ML00004752C[C@H]1OC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2cccc(O)c2O)[C@@H](C)OC(=O)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2cccc(O)c2O)[C@@H](C)OC(=O)[C@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)c1cccc(O)c1Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
680679ML00002454CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](O)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002454_numbered.png2026-03-19 06:54:54.139034
681680ML00010541CO[C@@H](CC[C@H](C)[C@H]1O[C@]23C[C@H](OC(=O)C[C@H]([C@@H](C)O)OC(=O)CC(=C(C)CC2(C)C)O3)[C@@H]1C)c1cccc(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
682681ML00008494C/C=C1\C(=O)OC=C2C(=O)OCC[C@@H]3C(=COC(=O)/C3=C\C)C(=O)OCC[C@H]21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
683682ML00004009O=C(O)C[C@@H](C(=O)O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@H](O)[C@@H](OC(=O)c1cc(O)c(O)c(O)c1)O2)[C@H]1c2c(cc(O)c(O)c2O)C(=O)O[C@H]1C(=O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
684683ML00001378CHEMBL1711308O=C1N[C@@H](Cc2c[nH]c3ccccc23)COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
685684ML00009101O=C1OC[C@@H](O)[C@H]([C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)c4c3C(=O)O[C@@H]2[C@H]4O)OC(=O)c2cc(O)c(O)c(O)c2-c2cc1c(O)c(O)c2Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
686685ML00007612CC/C(C)=C1\OC(=O)C(C)C(O)C(Cc2cccnc2)NC(=O)C(NC(=O)c2ncccc2O)C(C)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
687686ML00002698CC[C@H](C)[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002698_numbered.png2026-03-19 06:54:54.217645
688687ML00008602CC1CC(O)(C(C)Cl)C(=O)OC2CCN3CC=C(COC(=O)C1(C)O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
689688ML00008589C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
690689ML00001017CHEMBL2311090CCCCCCC[C@H]1OC(=O)CC(O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
691690ML00001158CHEMBL40333CCCCCCC[C@H]1OC(=O)C[C@@H](OCOC)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
692691ML00007908C=C1C(=O)OC2CCN3CC=C(COC(=O)C(C)(O)C4(CO4)C1C)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
693692ML00000582CHEMBL1704624O=C(C[C@H]1C/C=C\C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O[C@@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
694693ML00008609C/C=C1\CC(C)C(O)(CO)C(=O)OCC2=CCN3CCC(OC1=O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
695694ML00006751CC[C@H]1OC(=O)[C@@H](C)[C@@H](O[C@@H]2OCC[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@H](C)C(=O)/C=C\[C@@]1(C)Ostandard_macrolactone12.0success8.0[3, 4, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00006751_numbered.png2026-03-19 06:54:54.320193
696695ML00006748CC(C)[C@H]1NC(=O)[C@@H](C)[C@@H](O)C[C@H]([C@H](C)CCCC[C@H](C)O)OC(=O)[C@@H]2CCCN2C1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
697696ML00008269C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3(C)CC[C@H](OC1=O)[C@@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
698697ML00008649C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
699698ML00008069C[C@@H]1C[C@@H]2O[C@H]2[C@@H](O)C/C=C\[C@@H](O)CC(=O)O1standard_macrolactone12.0success3.0[3, 7, 11]ring_size_12/standard/numbered/ML00008069_numbered.png2026-03-19 06:54:54.372592
700699ML00008366COc1cc(OC(C)=O)cc2c1C(=O)OC(C)CCCCCCC2standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00008366_numbered.png2026-03-19 06:54:54.396627
701700ML00001033CHEMBL290635CCCCCCC[C@H]1OC(=O)C[C@H](O)[C@H](Cc2ccccc2)N(C)C(=O)C(C)(C)OC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
702701ML00001084CHEMBL1669762CC(=O)Oc1cc2c(c(OC(C)=O)c1)C(=O)O[C@H](C)CCCCCCC2standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00001084_numbered.png2026-03-19 06:54:54.471749
703702ML00007871C=C1C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@]4(CO4)[C@H]1C)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
704703ML00001059CHEMBL1079178COc1cc(O)c2c(c1)/C=C/C[C@@H](O)[C@@H](O)C(=O)/C(F)=C/OC2=Ostandard_macrolactone12.0success4.0[4, 5, 6, 7]ring_size_12/standard/numbered/ML00001059_numbered.png2026-03-19 06:54:54.524597
705704ML00006780CC[C@H](C)[C@@H]1NC(=O)C[C@H]2[C@@H]3OC(C)(C)O[C@H]3c3cc4c(cc3N2C/C=C\COC1=O)OCO4non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
706705ML00007627O=C(C[C@@H]1C/C=C\C[C@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](c2ccccc2)NC1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
707706ML00010294C[C@@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
708707ML00008587C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
709708ML00006715C/C=C1\C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@@](C)(OC(C)=O)[C@@H](C)[C@@H]1OC(C)=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
710709ML00007537CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)Ostandard_macrolactone12.0success8.0[3, 4, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007537_numbered.png2026-03-19 06:54:54.613203
711710ML00009903CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@H]3[C@@H]4C=C5C(=O)[C@H](C)[C@@H](O)CCC[C@H](C6CCC6)OC(=O)C[C@H]5[C@@H]4C=C(C)[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00009903_numbered.png2026-03-19 06:54:54.648515
712711ML00008072C[C@@H]1C/C=C\[C@H](O)C/C=C\[C@@H](O)CC(=O)O1standard_macrolactone12.0success3.0[3, 7, 11]ring_size_12/standard/numbered/ML00008072_numbered.png2026-03-19 06:54:54.677159
713712ML00008925O=C1N[C@H](Cc2ccccc2)COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
714713ML00005855CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@H]3[C@@H]4C=C5C(=O)[C@H](C)[C@@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)CCC[C@H](c6ccoc6)OC(=O)C[C@H]5[C@@H]4C=C(C)[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00005855_numbered.png2026-03-19 06:54:54.721672
715714ML00009989CC[C@H](C)[C@@H]1NC(=O)[C@@H]([C@H](C)CC)NC(=O)CC(=O)[C@H](C)[C@H](/C=C(\C)C[C@H](C)C/C(C)=C/C(=O)O)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
716715ML00008641C[C@H](O)[C@]1(O)C[C@]2(CO)O[C@]2(C)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
717716ML00008258C[C@@H]1C[C@]2(O[C@@H]2C)C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@]1(C)O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
718717ML00001198CHEMBL3260945CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)/C=C(/C)CCc3coc(/C=C\CNC(=O)OC)n3)C[C@H](CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
719718ML00007459CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)NC[C@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
720719ML00007868C=C1C[C@@]2(O[C@@H]2C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
721720ML00008353COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OCC(NC(=O)CCO)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
722721ML00009969CCCCCCC[C@H]1OC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)OC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
723722ML00000990CHEMBL2323585PYRIDOMYCINCC/C(C)=C1\OC(=O)[C@H](C)[C@H](O)[C@H](Cc2cccnc2)NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
724723ML00003035COC(=O)C[C@@]12Oc3c(O)c(O)cc(C(=O)O[C@@H]4[C@H]5COC(=O)c6cc(O)c(O)c(O)c6-c6c(cc(O)c(O)c6O)C(=O)O[C@@H]4[C@@H](O)[C@@H](OC(=O)c4cc(O)c(O)c(O)c4)O5)c3[C@@H]1[C@@H](C(=O)OC)OC2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
725724ML00008277CC1CC2(OC2C)C(=O)OC2CCN(C)C/C=C(/COC(=O)C1(C)O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
726725ML00002477CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](O)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)[C@@H](O)[C@H]4C=C[C@H]3[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002477_numbered.png2026-03-19 06:54:54.831418
727726ML00002380CCN[C@@H]1CC[C@@H](O[C@H]2CCC[C@@H](CC)OC(=O)C[C@@H]3C(=C[C@@H]4[C@@H]3C=C(C)[C@@H]3C[C@@H](O[C@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@@H]5OC)C[C@H]43)C(=O)[C@@H]2C)O[C@H]1Cstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002380_numbered.png2026-03-19 06:54:54.866973
728727ML00001772CHEMBL1087530O=C(C[C@H]1C/C=C/CCC(=O)O[C@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
729728ML00010539CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@@H](C)O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1ccc(Br)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
730729ML00004203O=C(O)C[C@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1C(=O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
731730ML00001386CHEMBL1727423O=C(C[C@@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
732731ML00008634C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
733732ML00002699CC[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](CC)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@H]4C(C)=C[C@H]3[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002699_numbered.png2026-03-19 06:54:54.943077
734733ML00010799O=C(C[C@@H]1C/C=C\C[C@H](Cc2ccc(F)cc2)C(=O)OC[C@@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
735734ML00000083CHEMBL1258349O=C1C[C@H]2CCC[C@]3(C[C@@H](C[C@@H](CCCCc4ccccc4)O3)OC(=O)C[C@H](CO)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
736735ML00006752C[C@H]1C[C@H](C)[C@H](O[C@@H]2OCC[C@H](N(C)C)[C@H]2O)[C@H](C)C(=O)O[C@H]([C@H](C)O)[C@@H](C)/C=C\C1=Ostandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00006752_numbered.png2026-03-19 06:54:55.004960
737736ML00007792COc1cc(O)cc2c1C(=O)O[C@@H](C)CC[C@H](O)CCCC2standard_macrolactone12.0success2.0[3, 6]ring_size_12/standard/numbered/ML00007792_numbered.png2026-03-19 06:54:55.031574
738737ML00002749CC[C@H](O)C[C@H](O)C/C=C(C)/C=C(C)\C=C(C)/C=C/C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1Cstandard_macrolactone12.0success4.0[3, 6, 8, 9]ring_size_12/standard/numbered/ML00002749_numbered.png2026-03-19 06:54:55.065888
739738ML00007412O=C(O)C[C@@H]1C(=O)O[C@@H]2[C@@H](COC(=O)c3cc4c(c(O)c3O)OC(=O)[C@H]41)O[C@@H](OC(=O)/C=C/c1ccc(O)c(O)c1)[C@H](O)[C@H]2Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
740739ML00005026O=C1O[C@H]2[C@@H]3COC(=O)c4cc(Oc5c(C(=O)O[C@H]6[C@H](OC(=O)c7cc(O)c(O)c(O)c7)O[C@H](COC(=O)c7cc(O)c(O)c(O)c7)[C@@H](O)[C@@H]6O)cc(O)c(O)c5O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@@H]2[C@H](OC(=O)c2cc(O)c(O)c4c2[C@H]2C1=CC(=O)C(O)(O)[C@@H]2O4)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
741740ML00008604C[C@H]1[C@@H](C)[C@](C)(O)C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@]1(O)CCl)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
742741ML00009039CC/C=C/[C@H]1CCC[C@H](O)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00009039_numbered.png2026-03-19 06:54:55.125742
743742ML00007170CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)NCCOC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
744743ML00009873COc1cc2cc(c1Cl)N1C[C@@H](O)[C@](C)(O)C(=O)N[C@@H](C)C(=O)O[C@H](CC1=O)[C@@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C\C=C(\C)[C@@H]2OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
745744ML00006791CC1(C)[C@H]2CC[C@@]13C(=O)N1C(=O)O[C@@H]([C@H]1Cl)C(Cl)(COCc1ccccc1)C(=O)OCCO[C@H]3C2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
746745ML00007843C[C@@H]1O[C@@]12C[C@]1(CO1)[C@@](C)(O)C(=O)OCC1=CCN3CC[C@@H](OC2=O)[C@@H]13non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
747746ML00010433C[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
748747ML00001771CHEMBL2152373O=C(C[C@@H]1C/C=C/CCC(=O)O[C@H](c2ccccc2)CNC1=O)NCc1cccc(Cl)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
749748ML00006931CC[C@@H]1C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@](C)(O)[C@H](C)[C@H]1OC(C)=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
750749ML00011004CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](C(C)(C)C)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
751750ML00007864C/C=C1/C[C@@]2(CO)O[C@]2(C)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
752751ML00010481CCC(=O)[C@H](C)[C@H]1O[C@H]1C[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010481_numbered.png2026-03-19 06:54:55.228306
753752ML00007856C=C1C/C(=C/C)C(=O)OC2CC[N+]3([O-])CC=C(COC(=O)C1(C)O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
754753ML00007097C[C@H]1COC(=O)[C@@H](CC(=O)OC(C)(C)C)C/C=C\C[C@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
755754ML00001935CHEMBL1474044O=C(C[C@@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@@H]2CCCN2C1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
756755ML00010801O=C(C[C@@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
757756ML00007769CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)NCCOC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
758757ML00008166C/C=C1\C[C@H](C)[C@@H](O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
759758ML00008450CCOc1cc2c(c(OCC)c1)C(=O)O[C@H](C)CCCCCCC2standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00008450_numbered.png2026-03-19 06:54:55.288988
760759ML00008115C[C@H]1CCC/C=C/C(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00008115_numbered.png2026-03-19 06:54:55.316519
761760ML00008067C[C@@H]1C[C@@H](O)CC(=O)C/C=C\[C@@H](O)CC(=O)O1standard_macrolactone12.0success4.0[3, 5, 7, 11]ring_size_12/standard/numbered/ML00008067_numbered.png2026-03-19 06:54:55.350392
762761ML00011003CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](C(C)(C)C)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
763762ML00000073CHEMBL2148108C[C@H]1[C@@H]2C[C@@]3(O[C@H](CCC3(C)C)CC(=O)O[C@@H](CO)CC(=O)O2)O[C@@H]1CCCCc1cccc(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
764763ML00008927O=C1N[C@@H](Cc2ccccc2)COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
765764ML00007583O=C(O[C@H]1[C@H](O)[C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC[C@H](O2)[C@H]1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
766765ML00008668C/C=C1\C[C@H](C)[C@@](C)(O)C(=O)OCC2=CCN3C[C@@H](O)[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
767766ML00004070O=C(O)/C=C1\C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)C2=CC(O)=C(O)[C@H]3OC(=O)C[C@@H]1[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
768767ML00010431C[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
769768ML00004033O=C(OC1COC(=O)c2cc(c(O)c(O)c2O)-c2c(cc(O)c(O)c2O)C(=O)OC1C1OC(=O)c2cc(O)c(O)c(O)c2-c2c(O)c(O)c(O)c3c2C(=O)OC1C3O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
770769ML00008472C/C=C1/C[C@@H](C)[C@@](C)(OC(C)=O)C(=O)OCc2ccn3c2[C@@H](CC3=O)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
771770ML00008653C/C=C1\CC(C)C(C)(O)C(=O)OCC2=CC[N+]3([O-])CCC(OC1=O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
772771ML00008625C[C@H]1C[C@@]2(O[C@@H]2C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
773772ML00002757CC/C=C/[C@H]1CCC[C@H](O[C@@H]2O[C@H](C)[C@@H](N(C)C)C[C@H]2O)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002757_numbered.png2026-03-19 06:54:55.473974
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775774ML00004201O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]3[C@H]1OC(=O)c1cc(O)c(O)c4c1[C@@H]([C@H](O)C(=O)O4)[C@](O)(C(=O)O)C(=O)O[C@@H]32)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
776775ML00008612C/C=C1/C[C@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
777776ML00008116C[C@@H]1CCC/C=C\C(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00008116_numbered.png2026-03-19 06:54:55.528707
778777ML00001753CHEMBL2323583CC(C)[C@H]1OC(=O)[C@H](C)[C@H](O)[C@H](Cc2cccnc2)NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
779778ML00007028C[C@H]1COC(=O)CC/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
780779ML00008643C/C=C1/C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
781780ML00008273C[C@@H]1O[C@@]12C[C@H](C)[C@@](C)(O)C(=O)OC/C1=C/CN(C)CC[C@@H](OC2=O)C1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
782781ML00008629C/C=C1/C[C@@H](C)[C@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
783782ML00010686CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
784783ML00006720COC(=O)[C@@H]1CSCc2c(O)cccc2C(=O)OCC(NC(=O)[C@H](CO)NC(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
785784ML00007071C=C1NC(=O)[C@H](CCCc2ccccc2)NC(=O)[C@H](C(C)C)OC(=O)[C@H](C)NC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
786785ML00008574C[C@@H]1C[C@]2(C)CC(=O)O[C@@H]3CC[N+]4([O-])CC[C@H](COC(=O)[C@]1(C)O2)[C@H]34non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
787786ML00002399C/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)[C@@H](O)[C@H]4C=C[C@H]3[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002399_numbered.png2026-03-19 06:54:55.629366
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789788ML00002401CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](NC)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002401_numbered.png2026-03-19 06:54:55.671967
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791790ML00009962CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@H]1C/C=C\[C@@H](OC(C)=O)[C@H](C)[C@H](O)C[C@H](O)CC(=O)O1standard_macrolactone12.0success5.0[3, 7, 8, 9, 11]ring_size_12/standard/numbered/ML00009962_numbered.png2026-03-19 06:54:55.719901
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794793ML00001777CHEMBL2152375O=C(C[C@@H]1C/C=C/CCC(=O)N[C@H](C2CCCCC2)COC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
795794ML00008081C[C@@H]1C[C@@H](O)C[C@@H](O)C/C=C\[C@@H](O)CC(=O)O1standard_macrolactone12.0success4.0[3, 5, 7, 11]ring_size_12/standard/numbered/ML00008081_numbered.png2026-03-19 06:54:55.810203
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797796ML00011021CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](C(C)(C)C)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
798797ML00008482C/C=C1\CC(C)C(C)(OC(C)=O)C(=O)OCc2ccn3c2C(CC3=O)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
799798ML00008074C[C@H]1CCC[C@@H](O)/C=C\[C@H](O)/C=C/C(=O)O1standard_macrolactone12.0success3.0[3, 7, 10]ring_size_12/standard/numbered/ML00008074_numbered.png2026-03-19 06:54:55.869165
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802801ML00006377O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]3[C@@H]2OC(=O)[C@@]24C[C@@]56O[C@@H]2[C@]2(OC[C@H](O)[C@@H]2O)O[C@@]5(O)[C@@]2(O)Oc5c(O)c(O)cc(c5[C@@H]4[C@]26O)C(=O)O[C@H]31)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
803802ML00008310CC[C@H]1C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@](C)(O)[C@H](C)[C@H]1O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
804803ML00006969O=C1O[C@@H](c2ccccc2)C[C@@H](O)[C@H](O)CCCCc2ccccc21standard_macrolactone12.0success3.0[3, 5, 6]ring_size_12/standard/numbered/ML00006969_numbered.png2026-03-19 06:54:55.952934
805804ML00008769CC[C@@]1(O)C[C@@H](C)[C@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
806805ML00006948CCCCC[C@@H]1C[C@H](O)CC(=O)O[C@H](CCCCC)C[C@H](O)CC(=O)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
807806ML00008316C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@@H](C2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
808807ML00004059O=C1O[C@@H]2[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](OC(=O)c3cc(O)c(O)c(O)c3)O[C@H](COC(=O)c3cc(O)c(O)c4c3[C@@H]3C1=CC(=O)[C@](O)(O4)C3(O)O)[C@H]2OC(=O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
809808ML00004641CCCCCC/C=C\CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)[C@@H](O)CC(=O)N[C@H](C(=O)N[C@@H]1/C=C\C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)OC1)C(C)C)C(C)Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
810809ML00000023CHEMBL1425538O=C(O[C@@H]1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@@H]2O)[C@H]1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
811810ML00004073O=C(OC1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC(C2OC(=O)c2cc(O)c(O)c(O)c2)C1OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
812811ML00010636CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
813812ML00006865CC(=O)O[C@@]1(C)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC(=O)[C@@]4(C[C@H]1C)O[C@@H]4C)[C@@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
814813ML00010882CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@@H]3CC[C@@H](C)[C@H](O)C[C@@](C)(CC/C=C/C=C\Br)OC(=O)C[C@](O)(C2)O3)[C@H](OC)[C@@H]1OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
815814ML00000978CHEMBL1159554O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]3[C@@H]2OC(=O)[C@@]24CC(=O)[C@@](O)(O[C@@]25C(=O)O[C@H]2C(O)CO[C@@]25O)C2(O)Oc5c(O)c(O)cc(c5C24)C(=O)C[C@@H]13)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
816815ML00007530CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]([N+](C)(C)[O-])[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)Ostandard_macrolactone12.0success8.0[3, 4, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007530_numbered.png2026-03-19 06:54:56.105539
817816ML00010018CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N[C@H](Cc2c[nH]c3ccccc23)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
818817ML00008463COC(=O)[C@H]1NC(=O)C(NC(=O)OC(C)(C)C)COC(=O)c2ccccc2CSC1Nnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
819818ML00010850CC(=O)O[C@H]1/C=C\[C@H](C)[C@H](/C(C)=C/C=C/[C@H](C)C[C@H]2O[C@@H]2[C@H](C)[C@@H](O)[C@H](C)O)OC(=O)C[C@H](O)C[C@@H](O)[C@@]1(C)Ostandard_macrolactone12.0success7.0[3, 4, 7, 8, 8, 9, 11]ring_size_12/standard/numbered/ML00010850_numbered.png2026-03-19 06:54:56.171419
820819ML00001919CHEMBL2368723Tellimagrandin IO=C(O[C@@H]1[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)C(O)O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3cc(c(O)c(O)c3O)C(=O)O[C@@H]12)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
821820ML00006753CN[C@H]1C[C@@H](C)O[C@@H](O[C@H]2[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@@H](C)[C@@H]([C@@H](C)O)OC(=O)[C@@H]2C)[C@@H]1Ostandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00006753_numbered.png2026-03-19 06:54:56.229574
822821ML00001682CHEMBL40066COCO[C@@H]1CC(=O)OC[C@H](C)C(=O)O[C@@H](C(C)C)C(=O)N(C)[C@H]1Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
823822ML00008287C/C=C1\CC(C)C(C)(O)C(=O)OC/C2=C/CN(C)CCC(OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
824823ML00007046COCCOCO[C@@H]1/C=C\COC(=O)/C=C/[C@@H](OC)[C@@H]2CCC(C)=C1C2(C)Cstandard_macrolactone12.0success4.0[6, 8, 8, 10]ring_size_12/standard/numbered/ML00007046_numbered.png2026-03-19 06:54:56.279795
825824ML00007801COc1cc(O)c2c(c1)CCCCCCC[C@H](C)OC2=Ostandard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00007801_numbered.png2026-03-19 06:54:56.304501
826825ML00001139CHEMBL1731097O=C1N[C@H](Cc2ccccc2)COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
827826ML00010806O=C1OC[C@H]2CCCN2C(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@@H]1Cc1ccc(F)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
828827ML00001953CHEMBL2420699CC[C@H](OC)[C@@H](C)[C@H]1C[C@@H]1[C@@H](O)[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00001953_numbered.png2026-03-19 06:54:56.363182
829828ML00008578C[C@@H]1C[C@]2(C)CC(=O)O[C@@H]3CCN4CC[C@H](COC(=O)[C@@]1(C)O2)[C@H]34non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
830829ML00008023C[C@H]1CCC(=O)/C=C/C(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success3.0[3, 6, 9]ring_size_12/standard/numbered/ML00008023_numbered.png2026-03-19 06:54:56.402165
831830ML00006604CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N2CCC[C@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
832831ML00002700CCC1=C[C@H]2[C@@H]3CC(=O)O[C@@H](CC)CCC[C@H](O[C@H]4CC[C@H](N(C)C)[C@@H](C)O4)[C@@H](C)C(=O)C3=C[C@H]2[C@@H]2C[C@H](O[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]3OC)C[C@@H]12standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002700_numbered.png2026-03-19 06:54:56.447734
833832ML00001014CHEMBL1242841PLADIENOLIDE ACC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](O)CC[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00001014_numbered.png2026-03-19 06:54:56.492523
834833ML00008064C[C@@H]1C/C=C\CCCCCCC(=O)O1standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00008064_numbered.png2026-03-19 06:54:56.516448
835834ML00001712CHEMBL1394201C[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
836835ML00003969O=C(O)/C=C(/C(=O)O[C@@H]1[C@H]2COC(=O)[C@H]3[CH][C@H](O)[C@@H](O)[C@@H](O)[C@H]3[C@@H]3[C@H](O)[C@H](O)[C@@H](O)[CH][C@H]3C(=O)O[C@@H]1[C@H](O)[C@@H](OC(=O)c1cc(O)c(O)c(O)c1)O2)[C@H]1c2c(cc(O)c(O)c2O)C(=O)O[C@@H]1C(=O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
837836ML00008294C[C@@H](O)[C@@]1(O)C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC1=O)[C@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
838837ML00004030O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3cc(c(O)c(O)c3O)C(=O)O[C@H]2[C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]12)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
839838ML00010845CC[C@H]1O[C@H](C[C@@H](C)/C=C/C=C(\C)[C@@H]2OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]2C)[C@@H](O)[C@]1(C)Ostandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010845_numbered.png2026-03-19 06:54:56.591090
840839ML00008620C[C@@H]1C[C@]2(C)CC(=O)O[C@@H]3CC[N+]4([O-])CC=C(COC(=O)[C@@]1(C)O2)[C@H]34non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
841840ML00006929CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@@](O)([C@H](C)O)C[C@H]1C)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
842841ML00008282C/C=C1/C[C@@H](C)[C@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
843842ML00008125COC(=O)[C@H](O)CS[C@@H]1CC(=O)O[C@@H](C)CCCCC[C@@H](O)C1=Ostandard_macrolactone12.0success4.0[3, 9, 10, 11]ring_size_12/standard/numbered/ML00008125_numbered.png2026-03-19 06:54:56.643151
844843ML00004077O=C(O)/C=C1\C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1[C@@H](O)C(=O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
845844ML00006917CC(=O)O[C@@]1(C)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC(=O)[C@](O)([C@H](C)O)C[C@@H]1C)[C@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
846845ML00010535CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)/C=C\[C@@](C)(OC(C)=O)[C@H](OC(C)=O)/C=C\[C@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010535_numbered.png2026-03-19 06:54:56.700460
847846ML00004050O=C(O)C[C@@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1[C@@](O)(C(=O)O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
848847ML00006628CCCCC[C@@H]1OC(=O)c2cc(ccc2C)Oc2ccc(O)c(CO)c2/C=C\[C@@H]1Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
849848ML00001864CHEMBL38750CC(C)[C@@H]1OC(=O)[C@@H](C)COC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
850849ML00000378CHEMBL164363411ALPHA-METHOXYCURVULARINCO[C@H]1CCC[C@H](C)OC(=O)Cc2cc(O)cc(O)c2C(=O)C1standard_macrolactone12.0success3.0[3, 7, 9]ring_size_12/standard/numbered/ML00000378_numbered.png2026-03-19 06:54:56.752329
851850ML00006982C=C/C1=C/C(C)C(C)(OC(C)=O)C(=O)OC/C2=C/CN(C)CCC(OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
852851ML00002070CHEMBL3623742Nc1cccc2c1C(=O)O[C@@H](C/C=C/NC(=O)C#Cc1ccccc1)C[C@@H](O)CC/C=C/C2standard_macrolactone12.0success2.0[3, 5]ring_size_12/standard/numbered/ML00002070_numbered.png2026-03-19 06:54:56.785054
853852ML00008215C[C@H]1CCC(=O)CCC(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success3.0[3, 6, 9]ring_size_12/standard/numbered/ML00008215_numbered.png2026-03-19 06:54:56.814093
854853ML00010298C[C@@H]1COC(=O)[C@@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
855854ML00010297C[C@H]1COC(=O)[C@@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
856855ML00001899CHEMBL1475192CO[C@H]1COC(=O)[C@H](C)COC(=O)[C@@H](OCc2ccccc2)/C=C\[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
857856ML00008767CC1C(C)C(O)(CO)C(=O)OCC2=CCN3CCC(OC(=O)C1(C)O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
858857ML00007546CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C/[C@H]1Cstandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007546_numbered.png2026-03-19 06:54:56.885205
859858ML00001920CHEMBL448796MALLOTINIC ACIDO=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(Oc4c(C(=O)O)cc(O)c(O)c4O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
860859ML00006990O=C(C[C@H]1C/C=C\C[C@H](Cc2ccc(F)cc2)C(=O)OCCNC1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
861860ML00009103O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@@H](O3)[C@@H](OC(=O)c3cc(O)c(O)c4c3[C@H]3C1=CC(=O)C(O)(O)[C@@]3(O)O4)[C@@H]2Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
862861ML00008468C/C=C1/C[C@H](C)[C@@](C)(OC(C)=O)C(=O)OCc2ccn3c2[C@@H](CC3=O)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
863862ML00006892COc1cc(O)c2c(c1C)C(=O)OC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](C(N)=O)CSC2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
864863ML00001019CHEMBL269137HAPALOSINCCCCCCC[C@H]1OC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
865864ML00009240CC/C=C/[C@H]1CCC[C@H](O)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00009240_numbered.png2026-03-19 06:54:56.961913
866865ML00007376CCC(=O)[C@@](C)(O)/C=C/C[C@@H](C)/C=C/[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00007376_numbered.png2026-03-19 06:54:57.003645
867866ML00007880C=C1C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@H](C)[C@H]1C)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
868867ML00007566O=C(O[C@@H]1O[C@@H]2COC(=O)c3c(O)c(O)c(O)c(O)c3-c3c(O)c(O)c(O)c(O)c3C(=O)O[C@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
869868ML00008164COC1=CC(=O)C=C2CCCCC(=O)CC[C@@H](C)OC(=O)[C@@]21Ostandard_macrolactone12.0success3.0[3, 6, 12]ring_size_12/standard/numbered/ML00008164_numbered.png2026-03-19 06:54:57.050343
870869ML00002435CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](C)(O[C@@H]4O[C@@H](C)C(=O)[C@@](C)(O)[C@H]4OC)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
871870ML00007857C=C1C/C(=C\C)C(=O)O[C@@H]2CC[N+]3([O-])CC=C(COC(=O)[C@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
872871ML00002283CC(=C/C[C@@H](O)C[C@H](C)O)/C=C(C)\C=C(C)/C=C/C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1Cstandard_macrolactone12.0success4.0[3, 6, 8, 9]ring_size_12/standard/numbered/ML00002283_numbered.png2026-03-19 06:54:57.105098
873872ML00001861CHEMBL1551632O=C1CC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NCCO1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
874873ML00001713CHEMBL2152371CC(C)(C)OC(=O)C[C@@H]1C/C=C/CCC(=O)N[C@H](c2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
875874ML00008613C[C@H]1O[C@]12C[C@@](O)(CO)[C@](C)(O)C(=O)OCC1=CCN3CC[C@@H](OC2=O)[C@@H]13non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
876875ML00009340CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
877876ML00009134O=C1NC[C@@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
878877ML00001978CHEMBL1992836O=C(N[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NCCOC1=O)OCC1c2ccccc2-c2ccccc21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
879878ML00000702CHEMBL506069GERANIINO=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]2C1=CC(=O)[C@](O)(O3)C2(O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
880879ML00007657C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)CCCC/C=C/C=C\[C@@H]1Cstandard_macrolactone12.0success2.0[3, 4]ring_size_12/standard/numbered/ML00007657_numbered.png2026-03-19 06:54:57.196101
881880ML00001203CHEMBL3260942CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)/C=C\CCc3coc(CCCNC(=O)OC)n3)C[C@H](CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
882881ML00000638CHEMBL1439490C=C1C/C(=C/C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
883882ML00007272Cc1cccc2c1C(=O)OC[C@H](NC(=O)C1C(O)CCC1C(=O)C(N)CO)C(=O)N[C@H](C(=O)NC(C)C(=O)O)CSC2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
884883ML00008261C/C=C1/CC[C@@](C)(OC(C)=O)C(=O)OC[C@@]2(O)CCN3CC[C@@H](OC1=O)[C@H]32non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
885884ML00009345CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
886885ML00010797O=C(C[C@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
887886ML00006880CC(=O)O[C@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@]3(C[C@H]1C)O[C@@H]3C)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
888887ML00006825C[C@H](N)C(=O)N1CC[C@@H](O)[C@H]1C(=O)N[C@H]1COC(=O)c2cc(O)cc(O)c2CSC[C@@H](C(=O)NCC(=O)O)NC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
889888ML00000337CHEMBL4073729CC(/C=C/C[C@@H](C)/C=C(C)/C=C/C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(\C)C[C@@H]1C)=C\[C@H](O)[C@@H](O)C[C@H](C)Ostandard_macrolactone12.0success4.0[3, 6, 8, 9]ring_size_12/standard/numbered/ML00000337_numbered.png2026-03-19 06:54:57.338415
890889ML00008275C[C@H]1C[C@]2(O[C@@H]2C)C(=O)O[C@H]2CCN(C)C/C=C(/COC(=O)[C@@]1(C)O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
891890ML00010072CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
892891ML00001011CHEMBL2381166CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4cc(O)ccc4I)O[C@@]1(C3)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
893892ML00008251CC1CCCCCCCc2cc(O)cc(O)c2C(=O)O1standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00008251_numbered.png2026-03-19 06:54:57.391691
894893ML00009343CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
895894ML00004186O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]3[C@H]1OC(=O)c1cc(O)c(O)c4c1[C@H]1[C@@](O)(C[C@@H](O)[C@@]1(O)O4)C(=O)O[C@@H]32)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
896895ML00006949CCCCC[C@@H]1C[C@@H](O)CC(=O)O[C@H](CCCCC)C[C@@H](O)CC(=O)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
897896ML00008175COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C(C)=C/OC2=Ostandard_macrolactone12.0success4.0[4, 5, 6, 7]ring_size_12/standard/numbered/ML00008175_numbered.png2026-03-19 06:54:57.449548
898897ML00010075CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
899898ML00004488O=C(NCCCCCC(=O)N1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1)c1cc(O)c(O)c(C(=O)N[C@H]2COC(=O)[C@@H](NC(=O)c3cccc(O)c3O)COC(=O)[C@@H](NC(=O)c3cccc(O)c3O)COC2=O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
900899ML00007859C=C1C/C(=C/C)C(=O)OC2CCN3CC=C(COC(=O)C1(O)CO)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
901900ML00007830C[C@H]1C[C@@H](C)C(=O)/C=C\[C@@H](C)[C@@H]([C@@H](C)O)OC(=O)[C@H](C)[C@H]1Ostandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007830_numbered.png2026-03-19 06:54:57.516958
902901ML00010146C[C@@H]1CCCCCCCc2cc(OC(=O)c3ccc(Cl)cc3)cc(OC(=O)c3ccc(Cl)cc3)c2C(=O)O1standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00010146_numbered.png2026-03-19 06:54:57.541213
903902ML00006760O=C(C[C@@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
904903ML00002806CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H]([C@H]6C[C@@H]6C)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002806_numbered.png2026-03-19 06:54:57.589168
905904ML00001022CHEMBL2381167COc1cccc(CCCC[C@@H]2C[C@@H]3C[C@@]4(O[C@H](CCC4(C)C)CC(=O)O[C@@H](CO)CC(=O)O3)O2)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
906905ML00002405C/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002405_numbered.png2026-03-19 06:54:57.637913
907906ML00006747CC(O)CCCCC(C)C1CC(O)C(C)C(=O)N[C@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
908907ML00005567CCCCCC/C=C\CC(=O)N[C@H](C(=O)N[C@@H](CO)[C@@H](O)CC(=O)N[C@H](C(=O)N[C@@H]1/C=C\C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)OC1)C(C)C)C(C)Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
909908ML00007461CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)NC[C@@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
910909ML00001934CHEMBL1356731CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](c2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
911910ML00000167CHEMBL473392ROBOTNIKININO=C(C[C@@H]1C/C=C/CCC(=O)O[C@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
912911ML00010071CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
913912ML00010843CC[C@H](O)[C@H](C)[C@H](O)[C@H](O)C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)/C=C\[C@@](C)(O)[C@H](OC(C)=O)/C=C\[C@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010843_numbered.png2026-03-19 06:54:57.729718
914913ML00004053O=C(O)C[C@]12OC(=O)[C@H](OC1=O)[C@H]2c1c(C(=O)O[C@H]2[C@H](OC(=O)c3cc(O)c(O)c(O)c3)O[C@@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]2[C@@H]3O)cc(O)c(O)c1Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
915914ML00008380C/C=C1\C[C@H](C)[C@@H](OC(C)=O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
916915ML00008245CC1CC(O)CCCCCc2cc(O)cc(O)c2C(=O)O1standard_macrolactone12.0success2.0[3, 5]ring_size_12/standard/numbered/ML00008245_numbered.png2026-03-19 06:54:57.774305
917916ML00007424COc1ccc2c(c1OC)-c1cc(ccc1O)/C=C\OC(=O)[C@H]1CCCCCCN[C@H]2C1standard_macrolactone12.0success0.0[]ring_size_12/standard/numbered/ML00007424_numbered.png2026-03-19 06:54:57.794529
918917ML00000986CHEMBL2381163CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4cc(O)c(Br)cc4Br)O[C@@]1(C3)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
919918ML00009339CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
920919ML00002849C=C/C=C\[C@H]1[C@@H]2/C=C\CC(=O)O[C@]34C[C@H](C)[C@]5(O)[C@H](C=C(CO)C[C@@]6(O)C(=O)C(C)=C[C@@H]65)[C@H]3[C@]4(C)COC(=O)[C@@H]2[C@H]2[C@@H](/C=C/C=C/C=C/CCC)[C@H]21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
921920ML00009098O=C1OC[C@H]2O[C@@H](O)[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]3[C@@H]2OC(=O)c2cc(O)c(O)c(O)c2-c2cc1c(O)c(O)c2Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
922921ML00008214C[C@@H]1CCC(=O)CCC(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success3.0[3, 6, 9]ring_size_12/standard/numbered/ML00008214_numbered.png2026-03-19 06:54:57.851243
923922ML00010542CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@@H]([C@@H](C)O)OC(=O)/C=C(\O2)[C@@](C)(O)CC3(C)C)[C@@H]1C)c1cccc(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
924923ML00010552O=C(C[C@@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@H]2CCCN2C1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
925924ML00002991O=C(N[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)COC1=O)OCC1c2ccccc2-c2ccccc21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
926925ML00008667C/C=C1\C[C@@H](C)[C@](C)(O)C(=O)OCC2=CCN3C[C@H](O)[C@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
927926ML00007659C/C(=C\[C@H](C)C(=O)CCCC1CC(=O)NC(=O)C1)[C@H]1OC(=O)/C=C\CC/C=C\C[C@@H](O)[C@@H]1Cstandard_macrolactone12.0success3.0[3, 4, 5]ring_size_12/standard/numbered/ML00007659_numbered.png2026-03-19 06:54:57.908849
928927ML00004197O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(Oc4c(C(=O)OC[C@H]5O[C@H](O)[C@@H](O)[C@H](O)[C@H]5O)cc(O)c(O)c4O)c(O)c3O)C(=O)O[C@H]([C@@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
929928ML00010432C[C@@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
930929ML00000635CHEMBL1512570C[C@H]1C[C@]2(O[C@@H]2C)C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@]1(C)O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
931930ML00007860C=C1C/C(=C\C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@@]1(O)CO)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
932931ML00010136O=C(NC1COC(=O)C(NC(=O)c2cccc(O)c2O)COC(=O)C(NC(=O)c2cccc(O)c2O)COC1=O)c1cccc(O)c1Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
933932ML00007578O=C(O[C@@H]1O[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]([C@@H]2O)[C@H]1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
934933ML00010682CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
935934ML00010278C[C@H](O)CCCC[C@H](C)[C@H]1C[C@H](O)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
936935ML00007146CO[C@H]1/C=C\CC/C=C\C(=O)O[C@H](/C(C)=C/[C@H](C)C(=O)CCCC2CC(=O)NC(=O)C2)[C@@H](C)[C@@H]1Ostandard_macrolactone12.0success4.0[3, 4, 5, 6]ring_size_12/standard/numbered/ML00007146_numbered.png2026-03-19 06:54:57.996411
937936ML00011022CC[C@H](C)[C@@H]1NC(=O)[C@@H]([C@H](C)CC)NC(=O)CC(=O)[C@H](C)[C@H](/C=C(\C)C[C@H](C)C/C(C)=C/c2cnco2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
938937ML00007651C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\C[C@@H](O)[C@@H]1Cstandard_macrolactone12.0success3.0[3, 4, 5]ring_size_12/standard/numbered/ML00007651_numbered.png2026-03-19 06:54:58.033178
939938ML00007863C/C=C1/C[C@]2(CO)O[C@]2(C)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
940939ML00002067CHEMBL3621526O=C(C#Cc1ccccc1)N/C=C/C[C@H]1C[C@@H](O)CC/C=C/Cc2cc([N+](=O)[O-])ccc2C(=O)O1standard_macrolactone12.0success2.0[3, 5]ring_size_12/standard/numbered/ML00002067_numbered.png2026-03-19 06:54:58.067089
941940ML00008289C[C@@H]1O[C@]12C[C@@H](C)[C@](C)(O)C(=O)OCC1=CC[N+]3(C)CC[C@@H](OC2=O)[C@]13Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
942941ML00006768Cc1c(O)cc(O)c2c1C(=O)OC[C@H](NC(=O)[C@@H]1[C@H](O)CCN1C(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@H](C(N)=O)CSC2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
943942ML00008210COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OCCC(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
944943ML00005328CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(=O)NCCCC[C@H](NC(=O)c2ccc(C3(C(F)(F)F)N=N3)cc2)C(=O)N(C)CCN(C)C(=O)CCCC[C@H]2SC[C@H]3NC(=O)N[C@H]32)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00005328_numbered.png2026-03-19 06:54:58.131235
945944ML00007624O=C1CC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
946945ML00007909C=C1C/C(=C/C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
947946ML00010973CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@@H](CO)OC(=O)/C=C(\O2)[C@](C)(O)CC3(C)C)[C@@H]1C)c1cccc(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
948947ML00007853COc1cc2c(c(OC)c1)C(=O)O[C@H](C)CCC/C=C/CC2standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00007853_numbered.png2026-03-19 06:54:58.173328
949948ML00006622O=C(CN1C/C=C/CCC(=O)N[C@H](c2ccccc2)COC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
950949ML00004205O=C(O)C1=C2c3c(C(=O)O[C@H]4[C@H](OC(=O)c5cc(O)c(O)c(O)c5)O[C@@H]5COC(=O)c6cc(O)c(O)c(O)c6-c6c(cc(O)c(O)c6O)C(=O)O[C@H]4[C@@H]5O)cc(O)c(O)c3O[C@]2(O)C(=O)C1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
951950ML00006450O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]3[C@H]1OC(=O)c1cc(O)c(O)c4c1C1C(O)(O4)[C@]4(O)C[C@@]5(C(=O)O[C@H]6C(O)CO[C@@]65O)[C@]1(CC4=O)C(=O)O[C@@H]32)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
952951ML00001021CHEMBL40070CCCCCCC[C@H]1OC(=O)CC[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
953952ML00010543CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@@H]([C@@H](C)O)OC(=O)/C=C(\O2)[C@](C)(O)CC3(C)C)[C@@H]1C)c1cccc(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
954953ML00008760C[C@@H](O)[C@@]1(O)C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
955954ML00006930CC(=O)OC1(C)C(=O)OC/C2=C/CN(C)CCC(OC(=O)C(O)(C(C)O)CC1C)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
956955ML00008111CO[C@@H]1CC(=O)C/C=C\[C@@H](O)CC(=O)O[C@H](C)C1standard_macrolactone12.0success4.0[3, 5, 7, 11]ring_size_12/standard/numbered/ML00008111_numbered.png2026-03-19 06:54:58.255625
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959958ML00007471COc1ccc(COC/C=C(\C)[C@@H]2C/C=C/[C@H](OC(C)=O)[C@](C)(O)CCCCC(=O)O2)cc1standard_macrolactone12.0success4.0[3, 7, 8, 8]ring_size_12/standard/numbered/ML00007471_numbered.png2026-03-19 06:54:58.335954
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961960ML00006607CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)N2CCC[C@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
962961ML00007434CC/C=C\C=C/C(=O)N/C=C\C[C@H]1C[C@@H](O)[C@@H](C)C/C=C/Cc2cccc(O)c2C(=O)O1standard_macrolactone12.0success3.0[3, 5, 6]ring_size_12/standard/numbered/ML00007434_numbered.png2026-03-19 06:54:58.384854
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964963ML00007451O=C1CCC2=C1[C@@H](O)OC1=C2[C@@]2(Cc3ccc(O)c(c3)-c3cc(ccc3O)CCOC2=O)OC1=Ostandard_macrolactone12.0success0.0[]ring_size_12/standard/numbered/ML00007451_numbered.png2026-03-19 06:54:58.415609
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966965ML00001135CHEMBL3260946CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)c3ccccc3CCc3coc(/C=C\CNC(=O)OC)n3)C[C@H](CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
967966ML00008170COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OCC/C(S)=N/1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
968967ML00010532CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)C[C@@H](OC(C)=O)[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success7.0[3, 4, 7, 8, 8, 9, 11]ring_size_12/standard/numbered/ML00010532_numbered.png2026-03-19 06:54:58.488149
969968ML00010728O=C1O[C@@H]2[C@@H](COC(=O)c3cc(O)c(O)c(O)c3-c3cc1c(O)c(O)c3O)O[C@@H](Oc1cc(O)c(C(=O)c3ccccc3)c(O)c1)[C@H](O)[C@H]2Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
970969ML00007885C[C@@H]1C[C@]2(C)CC(=O)O[C@@H]3CCN4CC=C(COC(=O)[C@@]1(C)O2)[C@H]34non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
971970ML00006928CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@](O)([C@H](C)O)C[C@H]1C)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
972971ML00008768CC[C@]1(O)C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
973972ML00010796O=C1OC[C@@H]2CCCN2C(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@H]1Cc1ccc(F)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
974973ML00011035CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](C(C)(C)C)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
975974ML00008773C/C=C1\C(=O)O[C@@H]2CCN3CC[C@H](COC(=O)[C@](C)(O)[C@H](C)[C@H]1O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
976975ML00000100CHEMBL525240CHEBULAGIC ACIDO=C(O)C[C@@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1[C@H](O)C(=O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
977976ML00005726CCCCCC/C=C\CC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CC(=O)N[C@H](C(=O)N[C@@H]1/C=C\C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)OC1)C(C)Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
978977ML00003128C/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C(C(=O)OC)[C@H]1CC(=O)OC[C@H]1[C@H]2C[C@H](OC(=O)C[C@@H]3C(=CO[C@@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)/C3=C/C)C(=O)OC[C@@H]2C)[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
979978ML00007168CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)NCCOC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
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989988ML00007653C/C(=C\[C@H](C)C(=O)CCCC1CC(=O)NC(=O)C1)[C@H]1OC(=O)/C=C\CC/C=C\[C@H](O)[C@@H](O)[C@@H]1Cstandard_macrolactone12.0success4.0[3, 4, 5, 6]ring_size_12/standard/numbered/ML00007653_numbered.png2026-03-19 06:54:58.832713
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991990ML00009931CO[C@@H]1[C@@H](O[C@H]2C[C@@]3(O)O[C@@H](C[C@@H](OC)/C=C(/C)C[C@H](/C=C/C=C/Br)OC(=O)[C@@H]3C)[C@@H]2C)O[C@H](C)[C@@H](OC)[C@@H]1Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
992991ML00007132COc1c(O)cc2c(c1O)C(=O)OC(C)C(O)c1c(O)c(O)c(OC)c(O)c1C(=O)OC(C)C2Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
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995994ML00007652C/C(=C\[C@H](C)C(=O)CCCC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\[C@H](O)[C@@H](O)[C@@H]1Cstandard_macrolactone12.0success4.0[3, 4, 5, 6]ring_size_12/standard/numbered/ML00007652_numbered.png2026-03-19 06:54:58.910971
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1000999ML00001831CHEMBL1669749C[C@@H]1CCCCCCCc2cc(O)cc(O)c2C(=O)O1standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00001831_numbered.png2026-03-19 06:54:59.032904
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10021001ML00008501COC(=O)[C@@H]1CSCc2c(O)cccc2C(=O)OCC(NC(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10031002ML00008800C/C=C1/CO[C@@H]2CCN3C[C@@H](O)[C@H](COC(=O)[C@](C)(O)[C@H](C)C1)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10041003ML00002756CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](/C=C/[C@H](C)O)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002756_numbered.png2026-03-19 06:54:59.093190
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10061005ML00004047O=C(O)C[C@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1[C@H](O)C(=O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10071006ML00010561O=C(C[C@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@@H]2CCCN2C1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10081007ML00000119CHEMBL3087768CC(=O)OCCOC(=O)[C@@H](CS[C@H]1CCC[C@H](C)OC(=O)Cc2cc(O)cc(O)c2C(=O)C1)OC(C)=Ostandard_macrolactone12.0success3.0[3, 7, 9]ring_size_12/standard/numbered/ML00000119_numbered.png2026-03-19 06:54:59.153497
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10101009ML00008563C[C@@H]1[C@@H](C)[C@](O)(CCl)C(=O)O[C@H]2CC[N+]3([O-])CC=C(COC(=O)[C@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10111010ML00004028O=C1C[C@]2(O)C(=O)O[C@H]3[C@@H]4OC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)OC[C@H]3O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]4OC(=O)c3cc(O)c(O)c4c3[C@H]2[C@H](O1)C(=O)O4non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10121011ML00007947C=C1C/C(=C/C)C(=O)OC2CCN3CC=C(COC(=O)C1(C)O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10131012ML00007456CCC(C)C1OC(=O)[C@@H](NC(=O)c2cccc(O)c2O)[C@H](C)OC(=O)C(C)(C)OC(CC(C)C)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10141013ML00010080CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10151014ML00009040CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](C6CCC6)CCC[C@H](O)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00009040_numbered.png2026-03-19 06:54:59.234339
10161015ML00008586C/C=C1/C[C@@H](C)[C@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10171016ML00008274C[C@@H]1O[C@@]12C[C@@H](C)[C@@](C)(O)C(=O)OC/C1=C/CN(C)CC[C@@H](OC2=O)C1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10181017ML00002379CC[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](CC)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002379_numbered.png2026-03-19 06:54:59.289191
10191018ML00001938CHEMBL1612084CC(C)(C)[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10201019ML00008611C/C=C1\C[C@@H](C)[C@@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10211020ML00001175CHEMBL2381161CC(=O)Nc1ccc(CCCC[C@@H]2C[C@@H]3C[C@@]4(O[C@H](CCC4(C)C)CC(=O)O[C@@H](CO)CC(=O)O3)O2)cc1Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10221021ML00008155COc1cc(O)cc2c1C(=O)O[C@H](C)CCC(=O)CCCC2standard_macrolactone12.0success2.0[3, 6]ring_size_12/standard/numbered/ML00008155_numbered.png2026-03-19 06:54:59.336777
10231022ML00007889C/C=C1\C[C@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10241023ML00007021C=CCOc1cc2c(c(OCC=C)c1)C(=O)O[C@H](C)CCCCCCC2standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00007021_numbered.png2026-03-19 06:54:59.366099
10251024ML00007910CC(=O)N[C@@H]1C/C=C/CCC(=O)N[C@H](c2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10261025ML00000315CHEMBL281952CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10271026ML00004069O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2OC(=O)c1cc(O)c(O)c(O)c1-c1c(C(=O)O)cc(O)c(O)c1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10281027ML00009495C[C@@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10291028ML00004052O=C(O)C[C@@]1(O)C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1[C@@H](C(=O)O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10301029ML00006695COC(=O)[C@@H]1CSCc2c(N)cccc2C(=O)OCC(NC(=O)[C@H](CO)NC(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10311030ML00006842CCCCOc1cc2c(c(OCCCC)c1)C(=O)O[C@H](C)CCCCCCC2standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00006842_numbered.png2026-03-19 06:54:59.434109
10321031ML00002340CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@H]3[C@@H]4C=C5C(=O)[C@H](C)[C@@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)CCC[C@H](CSC)OC(=O)C[C@H]5[C@@H]4C=C(C)[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002340_numbered.png2026-03-19 06:54:59.471159
10331032ML00008281C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10341033ML00009049C=C/C=C/[C@H]1CCC[C@H](O)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00009049_numbered.png2026-03-19 06:54:59.514830
10351034ML00008571CC[C@H]1C[C@@H](C)[C@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10361035ML00010838CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@](C)(O)/C=C/C=C(\C)[C@H]1OC(=O)C[C@@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010838_numbered.png2026-03-19 06:54:59.563194
10371036ML00001157CHEMBL1242467PLADIENOLIDE CCCC(=O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)CC[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00001157_numbered.png2026-03-19 06:54:59.604676
10381037ML00008567C[C@H]1C[C@@]2(C)CC(=O)O[C@@H]3CCN4CC[C@H](COC(=O)[C@@]1(C)O2)[C@H]34non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10391038ML00007735CC(=O)Oc1cc(O)cc2c1C(=O)/C=C\CCC[C@H](C)OC(=O)C2standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00007735_numbered.png2026-03-19 06:54:59.637933
10401039ML00008543C[C@@H]1C[C@@]2(C)CC(=O)O[C@@H]3CCN4CC[C@@H](COC(=O)[C@]1(C)O2)[C@H]34non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10411040ML00001796CHEMBL1585045C/C=C1/CC(C)C(C)(O)C(=O)OCC2CCN3CCC(OC1=O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10421041ML00009976CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C/[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00009976_numbered.png2026-03-19 06:54:59.692410
10431042ML00011034CCC[C@@H]1C[C@@H](OC)C[C@H](C)C[C@@H]2C[C@H](OC(=O)/C=C\CCc3coc(/C=C\CNC(=O)OC)n3)C[C@H](CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10441043ML00008028C[C@H]1CC/C=C\CC(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00008028_numbered.png2026-03-19 06:54:59.728453
10451044ML00007353CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1CC/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)CCC(=O)[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 5, 8, 8, 11]ring_size_12/standard/numbered/ML00007353_numbered.png2026-03-19 06:54:59.775607
10461045ML00007787COC1=CC(=O)C=C2CCCCCCC[C@@H](C)OC(=O)[C@@]21Ostandard_macrolactone12.0success2.0[3, 12]ring_size_12/standard/numbered/ML00007787_numbered.png2026-03-19 06:54:59.809467
10471046ML00009337CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10481047ML00006884CC(=O)OC1(C)C(=O)OC/C2=C/CN(C)CCC(OC(=O)C3(CC1C)OC3C)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10491048ML00007172CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N[C@H](Cc2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10501049ML00008062C[C@H]1CCCCC[C@@H](O)C(=O)CCC(=O)O1standard_macrolactone12.0success3.0[3, 9, 10]ring_size_12/standard/numbered/ML00008062_numbered.png2026-03-19 06:54:59.864617
10511050ML00006975COC(=O)[C@@H]1CSCc2ccc(O)c(C)c2C(=O)OCC(NC(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10521051ML00007518CC(C)(C)[C@H]1COC(=O)CC/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10531052ML00010166CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)[C@H](C)[C@H](O)CC[C@@](C)(O)[C@@H](O)/C=C\[C@H]1Cstandard_macrolactone12.0success7.0[3, 4, 7, 8, 8, 11, 12]ring_size_12/standard/numbered/ML00010166_numbered.png2026-03-19 06:54:59.941962
10541053ML00008039O=C1OCCCCCCCCc2cc(O)cc(O)c21standard_macrolactone12.0success0.0[]ring_size_12/standard/numbered/ML00008039_numbered.png2026-03-19 06:55:00.015007
10551054ML00001377CHEMBL1729751O=C1N[C@H](Cc2c[nH]c3ccccc23)COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10561055ML00007865C/C=C1/C[C@]2(CO)O[C@@]2(C)C(=O)OCC2=CCN3CC[C@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10571056ML00008117C/C=C1/C[C@@H](C)[C@@H](O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10581057ML00001575CHEMBL1717330O=C(N[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)COC1=O)OCC1c2ccccc2-c2ccccc21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10591058ML00007563O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10601059ML00007528CC[C@@H](C)[C@H]1NC(=O)C(C)C(O)CC(C(C)CCCCC(C)O)OC(=O)[C@@H]2CCCN2C1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10611060ML00004198O=C(O[C@@H]1[C@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC[C@@H](O[C@@H]1Oc1cc(O)c(O)c(O)c1)[C@H]2O)c1cc(O)c(O)c(Oc2cc(O)c(O)c(O)c2C(=O)O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10621061ML00002813C=C/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002813_numbered.png2026-03-19 06:55:00.110729
10631062ML00007562O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]([C@@H]2O)[C@H]1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10641063ML00008336COC1=CC(O)C2C(=O)O[C@@H](C)CC3CC(=O)[C@@H](O)[C@H](C/C=C/C2=C1)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10651064ML00008100C[C@H]1CCCCC[C@H](O)C(=O)[C@@H](O)CC(=O)O1standard_macrolactone12.0success4.0[3, 9, 10, 11]ring_size_12/standard/numbered/ML00008100_numbered.png2026-03-19 06:55:00.161694
10661065ML00008208C[C@H]1CCCCCC(=O)Cc2cc(O)cc(O)c2C(=O)O1standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00008208_numbered.png2026-03-19 06:55:00.190970
10671066ML00000731CHEMBL1771486O=C1CC/C=C/CCC(=O)N(Cc2cccc(/C=N/NC(=O)c3cccc(C(=O)NO)c3)c2)C[C@@H](c2ccccc2)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10681067ML00009876COc1cc2cc(c1Cl)N1CC[C@](C)(O)C(=O)N[C@@H](C)C(=O)O[C@@H](CC1=O)[C@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C\C=C(\C)[C@H]2OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10691068ML00008519C/C=C1\C[C@@]2(COC(C)=O)O[C@]2(C)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10701069ML00008218C[C@H]1CCC[C@H]2O[C@@H]2C(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00008218_numbered.png2026-03-19 06:55:00.243150
10711070ML00007952C=C1C/C(=C/C)C(=O)O[C@@H]2C=CN3CC[C@@H](COC(=O)[C@@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10721071ML00000048CHEMBL449392CORILAGINO=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10731072ML00008562C[C@@H]1[C@@H](C)[C@](O)(CCl)C(=O)O[C@@H]2CC[N+]3([O-])CC=C(COC(=O)[C@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10741073ML00002804CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002804_numbered.png2026-03-19 06:55:00.310040
10751074ML00008770CC[C@]1(O)C[C@@H](C)[C@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10761075ML00010805O=C1OC[C@@H]2CCCN2C(=O)[C@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@H]1Cc1ccc(F)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10771076ML00006736O=C(C[C@@H]1CC=CCCC(=O)O[C@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10781077ML00008561C[C@H](Cl)[C@@]1(O)C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10791078ML00008156COc1cc(O)cc2c1C(=O)O[C@@H](C)CC(=O)CCCCC2standard_macrolactone12.0success2.0[3, 5]ring_size_12/standard/numbered/ML00008156_numbered.png2026-03-19 06:55:00.363340
10801079ML00010836CC(=O)O[C@H]1/C=C\[C@H](C)[C@H](/C(C)=C/C=C/[C@H](C)C[C@H]2O[C@@H]2[C@H](C)[C@@H](O)[C@H](C)O)OC(=O)C[C@H](O)CC[C@]1(C)Ostandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010836_numbered.png2026-03-19 06:55:00.405286
10811080ML00003973O=C(O)C[C@@H](C(=O)O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@@H](O)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O2)[C@H]1c2c(cc(O)c(O)c2O)C(=O)O[C@H]1C(=O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10821081ML00008762C[C@H](O)[C@@]1(O)C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10831082ML00004017O=C1O[C@H]2[C@H](OC(=O)c3cc(O)c(O)c(O)c3)O[C@@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]2[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]2C1=CC(=O)C(O)(O)[C@@]2(O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10841083ML00001791CHEMBL1591009SPARTIOIDINEC=C1C/C(=C\C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10851084ML00007302O=C1NCCOC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10861085ML00000818CHEMBL1732831C[C@@H]1COC(=O)[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10871086ML00008759C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2[C@H](O)C[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10881087ML00007850COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OC[C@H](C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10891088ML00008152CC1CCCC2OC2C(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00008152_numbered.png2026-03-19 06:55:00.489374
10901089ML00006830CC(C)C(=O)Oc1cc2c(c(OC(=O)C(C)C)c1)C(=O)O[C@H](C)CCCCCCC2standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00006830_numbered.png2026-03-19 06:55:00.512813
10911090ML00008469C/C=C1/C[C@@H](C)[C@](C)(OC(C)=O)C(=O)OCc2ccn3c2[C@H](CC3=O)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10921091ML00007555CO[C@H](CC(=O)O)[C@@H](C)C(=O)[C@H](C)/C=C(\C)[C@H]1OC(=O)[C@H](O)[C@H](O)/C=C\[C@H](C)CCC[C@@H]1Cstandard_macrolactone12.0success5.0[3, 4, 8, 11, 12]ring_size_12/standard/numbered/ML00007555_numbered.png2026-03-19 06:55:00.555899
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10951094ML00004024O=C1O[C@@H]2[C@@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]2[C@H](OC(=O)c2cc(O)c(O)c4c2[C@H]2C1=CC(=O)[C@](O)(O4)C2(O)O)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10961095ML00000262CHEMBL4105086C[C@H]1CCC/C=C/C(=O)c2c(cc(O)c(Cl)c2O)CC(=O)O1standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00000262_numbered.png2026-03-19 06:55:00.633054
10971096ML00007640C/C=C1/[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OC[C@H](C)[C@]3(O)[C@@H](O)C[C@H](C)[C@H]3COC(=O)C[C@H]21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10981097ML00000596CHEMBL2152376O=C(C[C@@H]1C/C=C/CCC(=O)N[C@H](Cc2ccccc2)COC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10991098ML00008271C[C@H]1C[C@@]2(O[C@@H]2C)C(=O)O[C@@H]2CC[N+]3(C)CC=C(COC(=O)[C@]1(C)O)[C@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11001099ML00008113C[C@H]1CCCCCC[C@H](O)[C@H](O)CC(=O)O1standard_macrolactone12.0success3.0[3, 10, 11]ring_size_12/standard/numbered/ML00008113_numbered.png2026-03-19 06:55:00.682084
11011100ML00010196O=C(C[C@@H]1C/C=C\C[C@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](Cc2c[nH]c3ccccc23)NC1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11021101ML00006376O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]3[C@@H]2OC(=O)[C@@]24[C@@H]5c6c(cc(O)c(O)c6O[C@]5(O)[C@@]5(O)O[C@]2(C(=O)O)[C@]2(O)O[C@@]5(O)[C@H]4[C@@]2(O)[C@@H](O)CO)C(=O)O[C@H]31)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11031102ML00008290C[C@@H]1C[C@]2(O[C@@H]2C)C(=O)O[C@@H]2CC[N+]3(C)CC=C(COC(=O)[C@@]1(C)O)[C@@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11041103ML00007095C[C@@H]1COC(=O)[C@@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11051104ML00007907C=C1C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@@]4(CO4)[C@@H]1C)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11061105ML00008626CC1CC2(OC2C)C(=O)OC2CCN3CC=C(COC(=O)C1(C)O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11071106ML00002639CC[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002639_numbered.png2026-03-19 06:55:00.797073
11081107ML00008020C[C@@H]1CCC(=O)C[C@@H]2Oc3cc(O)cc(c3C2=O)CC(=O)O1standard_macrolactone12.0success3.0[3, 6, 9]ring_size_12/standard/numbered/ML00008020_numbered.png2026-03-19 06:55:00.827429
11091108ML00006887C/C=C1/C[C@@H](C)[C@](C)(OC(C)=O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11101109ML00001818CHEMBL3400934C/C1=C\CCC(C)C(C)OC(=O)Cc2cc(O)cc(O)c2C1=Ostandard_macrolactone12.0success4.0[3, 4, 8, 9]ring_size_12/standard/numbered/ML00001818_numbered.png2026-03-19 06:55:00.868045
11111110ML00008429CC[C@@H]1C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@@H](C)[C@H]1OC(C)=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11121111ML00008191CC1CCCC(O)CC(=O)Cc2cc(O)cc(O)c2C(=O)O1standard_macrolactone12.0success3.0[3, 7, 9]ring_size_12/standard/numbered/ML00008191_numbered.png2026-03-19 06:55:00.906576
11131112ML00007482C/C(=C\[C@H](C)C(=O)/C=C/CC1CC(=O)NC(=O)C1)[C@H]1OC(=O)/C=C\CC/C=C\C[C@@H](O)[C@@H]1Cstandard_macrolactone12.0success3.0[3, 4, 5]ring_size_12/standard/numbered/ML00007482_numbered.png2026-03-19 06:55:00.938422
11141113ML00007647C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\[C@H](O)[C@@H](O)[C@@H]1Cstandard_macrolactone12.0success4.0[3, 4, 5, 6]ring_size_12/standard/numbered/ML00007647_numbered.png2026-03-19 06:55:00.972860
11151114ML00007274CC[C@H](C)[C@H]1OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC(=O)[C@@H](C)C(=O)[C@H](CC(C)C)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11161115ML00010692CC/C=C/C=C\CC[C@]1(C)C[C@H](O)[C@H](C)CC[C@H]2C[C@@H](C[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]3OC)C[C@@](O)(CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11171116ML00000155CHEMBL1396368C=C1C/C(=C\C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11181117ML00001690CHEMBL2152372CN1C[C@@H](c2ccccc2)OC(=O)CC/C=C/C[C@@H](Cc2ccc(Cl)cc2)C1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11191118ML00008311CC[C@@H]1C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@](C)(O)[C@H](C)[C@H]1O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11201119ML00008485C=C1C(=O)OC2CC(=O)n3ccc(c32)COC(=O)C(C)(OC(C)=O)C(C)C1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11211120ML00010860CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1[C@H](O)[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)/C=C\[C@@](C)(O)[C@H](OC(C)=O)/C=C\[C@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010860_numbered.png2026-03-19 06:55:01.059812
11221121ML00002066CHEMBL3623741O=C(C#Cc1ccccc1)N/C=C/C[C@H]1C[C@@H](O)CC/C=C/Cc2cccc([N+](=O)[O-])c2C(=O)O1standard_macrolactone12.0success2.0[3, 5]ring_size_12/standard/numbered/ML00002066_numbered.png2026-03-19 06:55:01.089847
11231122ML00008520C=C1C/C(=C/C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)OC(C)=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11241123ML00010844CC[C@H](O)[C@](C)(O)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010844_numbered.png2026-03-19 06:55:01.142977
11251124ML00009238CC/C=C/[C@H]1CCC[C@H](O)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5O)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00009238_numbered.png2026-03-19 06:55:01.180173
11261125ML00007455CC/C=C\C=C/C(=O)N/C=C\C[C@@H]1C[C@H](O)[C@H](C)C/C=C\Cc2cccc(O)c2C(=O)O1standard_macrolactone12.0success3.0[3, 5, 6]ring_size_12/standard/numbered/ML00007455_numbered.png2026-03-19 06:55:01.215119
11271126ML00001951CHEMBL282159CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23CC(OC(=O)C[C@H]([C@@H](C)O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cccc(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11281127ML00003970O=C(O)C[C@@H]1C(=O)O[C@@H]2[C@H]3OC(=O)c4cc(O)c(O)c5c4[C@@H]([C@H](O)C(=O)O5)[C@H](CC(=O)O)C(=O)O[C@@H]2[C@@H](COC(=O)c2cc(O)c(O)c4c2[C@H]1[C@H](O)C(=O)O4)O[C@H]3OC(=O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11291128ML00006918CC[C@@H]1C(=O)O[C@@H]2CC[N+]3(C)CC=C(COC(=O)[C@](C)(O)[C@H](C)[C@H]1OC(C)=O)[C@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11301129ML00009877COc1cc2cc(c1Cl)N1CCC(C)(O)C(=O)NC(C)C(=O)O[C@@H](CC1=O)[C@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C/C=C(\C)C2OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11311130ML00009250CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H]4NC(=O)O[C@@]4(C)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11321131ML00009151O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(Oc4c(C(=O)O)cc(O)c(O)c4O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11331132ML00006986C[C@H]1CCC/C=C\[C@H]2CC[C@H](OC(=O)c3cccc(Br)c3)[C@@H](CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11341133ML00008633C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11351134ML00006866CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@@]3(C[C@H]1C)O[C@@H]3C)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11361135ML00001829CHEMBL1077886COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C(I)=C/OC2=Ostandard_macrolactone12.0success4.0[4, 5, 6, 7]ring_size_12/standard/numbered/ML00001829_numbered.png2026-03-19 06:55:01.326887
11371136ML00000129CHEMBL223238NEOPELTOLIDECCC[C@@H]1C[C@H](OC)C[C@H](C)C[C@@H]2C[C@@H](OC(=O)/C=C\CCc3coc(/C=C\CNC(=O)OC)n3)C[C@H](CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11381137ML00008636C/C=C1\C[C@@H](C)[C@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11391138ML00007145CO[C@H]1/C=C/CC/C=C/C(=O)O[C@@H](/C(C)=C/[C@H](C)C(=O)CCCC2CC(=O)NC(=O)C2)[C@@H](C)[C@@H]1Ostandard_macrolactone12.0success4.0[3, 4, 5, 6]ring_size_12/standard/numbered/ML00007145_numbered.png2026-03-19 06:55:01.378930
11401139ML00007568O=C(C#Cc1ccccc1)N/C=C/C[C@H]1C[C@@H](O)CC/C=C/Cc2cc(O)ccc2C(=O)O1standard_macrolactone12.0success2.0[3, 5]ring_size_12/standard/numbered/ML00007568_numbered.png2026-03-19 06:55:01.408218
11411140ML00010516CO[C@H](CC[C@@H](C)[C@@H]1O[C@@]23C[C@@H](OC(=O)C[C@@H]([C@H](C)O)OC(=O)CC(=C(C)CC2(C)C)O3)[C@H]1C)c1cc(O)ccc1Brnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11421141ML00008582C/C=C1/C[C@@H](C)[C@](C)(O)C(=O)OC[C@H]2[C@H](O)CN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11431142ML00009296CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](OC(C)=O)CC[C@](O)(COC(C)=O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00009296_numbered.png2026-03-19 06:55:01.470271
11441143ML00008426C/C=C1\C[C@H](C)[C@@](C)(OC(C)=O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11451144ML00010582CC/C=C/C=C/CC[C@@]1(C)C[C@@H](O)[C@@H](C)CC[C@@H]2C[C@H](O[C@H]3O[C@H](C)[C@@H](OC)[C@H](O)[C@@H]3OC)C[C@](O)(CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11461145ML00003127C/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C(C(=O)OC)[C@H]1CC(=O)OC[C@H]1[C@H]2C[C@H](OC(=O)C[C@@H]3C(=CO[C@@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)/C3=C/C)C(=O)OC[C@H]2C)[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11471146ML00008058C[C@@H]1CCCC(=O)CCC[C@@H](O)CC(=O)O1standard_macrolactone12.0success3.0[3, 7, 11]ring_size_12/standard/numbered/ML00008058_numbered.png2026-03-19 06:55:01.525646
11481147ML00002398CN[C@H]1CC[C@H](O[C@H]2CCC[C@H](/C=C/[C@H](C)O)OC(=O)C[C@@H]3C(=C[C@@H]4[C@H]3C=C[C@@H]3C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]43)C(=O)[C@@H]2C)O[C@@H]1Cstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002398_numbered.png2026-03-19 06:55:01.564778
11491148ML00000363CHEMBL2152380O=C(C[C@@H]1C/C=C/CCC(=O)N[C@H](c2ccc(Cl)cc2)COC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11501149ML00006717C=C1NC(=O)[C@H](CCCc2ccc(OC)cc2)NC(=O)[C@H](C(C)C)OC(=O)[C@H](C)NC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11511150ML00010837CC[C@H](O)[C@@H](C)[C@H]1O[C@H]1C[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@@H](O)CC[C@@](O)(COC(C)=O)[C@@H](O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010837_numbered.png2026-03-19 06:55:01.624590
11521151ML00002402CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002402_numbered.png2026-03-19 06:55:01.664410
11531152ML00000636CHEMBL1314833Cc1ccc(S(=O)(=O)N[C@H]2COC(=O)[C@@H](C)COC(=O)C/C=C\[C@H]2C)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11541153ML00007879C=C1C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@@](C)(O)[C@H](C)[C@H]1C)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11551154ML00008608C/C=C1/C[C@@H](CO)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11561155ML00006827O=C(C[C@@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@@H]2CCCN2C1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11571156ML00009663CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11581157ML00010863CO[C@@H]1[C@H](O)[C@@H](O[C@@H]2C[C@]3(O)CC(=O)O[C@@](C)(CC/C=C/C=C/Br)C[C@H](O)[C@@H](C)CC[C@@H](O3)[C@H]2C)O[C@H](C)[C@H]1OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11591158ML00007650C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\[C@@H](O)C[C@@H]1Cstandard_macrolactone12.0success3.0[3, 4, 6]ring_size_12/standard/numbered/ML00007650_numbered.png2026-03-19 06:55:01.741685
11601159ML00010430C[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11611160ML00007532C[C@H]1C[C@@H](C)C(=O)/C=C\[C@](C)(O)[C@@H]([C@@H](C)O)OC(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H]([NH+](C)C)[C@H]1Ostandard_macrolactone12.0success8.0[3, 4, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007532_numbered.png2026-03-19 06:55:01.800947
11621161ML00009904CC/C=C/[C@H]1CCC[C@H](O)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)[C@@H](O)[C@H]4C(C)=C[C@H]3[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00009904_numbered.png2026-03-19 06:55:01.838918
11631162ML00009129O=C(C[C@H]1C/C=C\C[C@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)N[C@@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11641163ML00009237CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@@H](C)OC(C)=O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cccc(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11651164ML00010300C[C@@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11661165ML00008061C[C@@H]1CCCCC[C@@H](O)[C@H](O)/C=C\C(=O)O1standard_macrolactone12.0success3.0[3, 9, 10]ring_size_12/standard/numbered/ML00008061_numbered.png2026-03-19 06:55:01.892120
11671166ML00001836CHEMBL3916007COc1cc(O)cc2c1C(=O)O[C@@H](C)CCC[C@H](O)CCC2standard_macrolactone12.0success2.0[3, 7]ring_size_12/standard/numbered/ML00001836_numbered.png2026-03-19 06:55:01.919795
11681167ML00008422C/C=C1/C[C@@H](COC(C)=O)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11691168ML00008091C[C@H]1CCC/C=C\[C@H]2C=C[C@H](O)[C@H](CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11701169ML00009494C[C@@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11711170ML00008219C[C@H]1CCC[C@H]2O[C@H]2C(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00008219_numbered.png2026-03-19 06:55:01.970252
11721171ML00008283C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@H](OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11731172ML00001795CHEMBL1599718C/C=C1\C[C@H](C)[C@@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11741173ML00010333CCCCCCC[C@H]1OC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CCSC)OC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11751174ML00006972COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OC[C@@H](NC(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11761175ML00008935O=C(C[C@@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O[C@H](c2ccccc2)CNC1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11771176ML00009309CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11781177ML00001194CHEMBL2420698CC[C@H](OC)[C@@H](C)[C@H]1C[C@@H]1[C@@H](O)[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00001194_numbered.png2026-03-19 06:55:02.060429
11791178ML00007364CC[C@H](O)[C@](C)(O)/C=C/C[C@@H](C)/C=C/[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00007364_numbered.png2026-03-19 06:55:02.105758
11801179ML00010109CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11811180ML00009056CCCC[C@H]1CCC[C@H](O)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00009056_numbered.png2026-03-19 06:55:02.151447
11821181ML00000876CHEMBL1240974CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(=O)NCCCC[C@H](NC(=O)c2ccc(C3(C(F)(F)F)N=N3)cc2)C(=O)N(C)CCN(C)C(=O)CCCC[C@H]2SC[C@H]3NC(=O)N[C@H]32)CC[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00000876_numbered.png2026-03-19 06:55:02.202355
11831182ML00001794CHEMBL1321908C/C=C1\C[C@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11841183ML00005779CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@H]4C(C)=C[C@H]3[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00005779_numbered.png2026-03-19 06:55:02.248843
11851184ML00010834CCC(O)C(C)C1OC1CC(C)/C=C/C=C(/C)C1OC(=O)CC(O)CCC(C)(O)C(OC(C)=O)/C=C\C1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010834_numbered.png2026-03-19 06:55:02.291037
11861185ML00002229O=C(N[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](c2ccccc2)COC1=O)OCC1c2ccccc2-c2ccccc21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11871186ML00010655CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](c2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11881187ML00008771C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11891188ML00000081CHEMBL1258117CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4ccccc4)O[C@@]1(C3)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11901189ML00008577C/C=C1\CC(C)C(C)(O)C(=O)OCC2C(O)CN3CCC(OC1=O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11911190ML00010195O=C(C[C@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](Cc2c[nH]c3ccccc23)NC1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11921191ML00008624C[C@@H]1O[C@@]12C[C@@H](C)[C@@](C)(O)C(=O)OCC1=CCN3CC[C@@H](OC2=O)[C@@H]13non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11931192ML00006755CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1Cstandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00006755_numbered.png2026-03-19 06:55:02.387659
11941193ML00002702CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3CC[C@H]4[C@@H]5CC(=O)O[C@@H](C6CCC6)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002702_numbered.png2026-03-19 06:55:02.426456
11951194ML00008265C[C@@H]1O[C@]12C[C@@H](C)[C@@](C)(O)C(=O)OCC1=CC[N+]3(C)CC[C@@H](OC2=O)[C@@]13Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11961195ML00010654CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11971196ML00008246C[C@@H]1CC[C@@H](O)CCCCc2cc(O)cc(O)c2C(=O)O1standard_macrolactone12.0success2.0[3, 6]ring_size_12/standard/numbered/ML00008246_numbered.png2026-03-19 06:55:02.468372
11981197ML00010634CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
11991198ML00007480C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C/CC/C=C/C=C\[C@@H]1Cstandard_macrolactone12.0success2.0[3, 4]ring_size_12/standard/numbered/ML00007480_numbered.png2026-03-19 06:55:02.505288
12001199ML00004057O=C(O[C@@H]1O[C@@H]2COC(=O)c3c(O)c(O)c(O)c(O)c3-c3c(O)c(O)c(O)c(O)c3C(=O)O[C@H]([C@H]1OC(=O)c1cc(O)c(O)c(O)c1)[C@@H]2OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12011200ML00009872COc1cc2cc(c1Cl)N1C[C@@H](O)[C@@](C)(O)C(=O)N[C@H](C)C(=O)O[C@@H](CC1=O)[C@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C\C=C(\C)[C@H]2OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12021201ML00002803CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002803_numbered.png2026-03-19 06:55:02.563847
12031202ML00001792CHEMBL1669746COc1cc2c(c(OC)c1)C(=O)O[C@H](C)CCC/C=C\CC2standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00001792_numbered.png2026-03-19 06:55:02.587998
12041203ML00006841CC/C=C/C(C)=C/[C@H](C)C[C@H](O)[C@@H]1/C=C\CC[C@H](C)C(=O)CC[C@H](C)C(=O)O1standard_macrolactone12.0success4.0[3, 8, 9, 12]ring_size_12/standard/numbered/ML00006841_numbered.png2026-03-19 06:55:02.621901
12051204ML00007533C[C@H]1C[C@@H](C)C(=O)/C=C\[C@](C)(O)[C@@H]([C@@H](C)O)OC(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1Ostandard_macrolactone12.0success8.0[3, 4, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007533_numbered.png2026-03-19 06:55:02.673974
12061205ML00010970CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H](CO)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cc(O)ccc1Brnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12071206ML00010862CC(=O)O[C@H]1/C=C\[C@H](C)[C@H](/C(C)=C/C=C/[C@H](C)C[C@@H](O)/C=C(\C)C(=O)[C@@H](C)O)OC(=O)C[C@H](O)CC[C@@]1(C)Ostandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010862_numbered.png2026-03-19 06:55:02.727918
12081207ML00007151CO[C@H]1/C=C\CC/C=C\C(=O)O[C@@H](/C(C)=C/[C@H](C)C(=O)C[C@H](O)CC2CC(=O)NC(=O)C2)[C@@H](C)[C@@H]1Ostandard_macrolactone12.0success4.0[3, 4, 5, 6]ring_size_12/standard/numbered/ML00007151_numbered.png2026-03-19 06:55:02.766043
12091208ML00008314C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@@H](C2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12101209ML00006886C/C=C1/C[C@@H](C)[C@@](C)(OC(C)=O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12111210ML00010293C[C@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12121211ML00009150O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3Oc3c(C(=O)O)cc(O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12131212ML00001773CHEMBL2152360O=C(C[C@@H]1C/C=C/CCC(=O)N[C@@H](c2ccccc2)COC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12141213ML00005778CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@H]3[C@@H]4C=C5C(=O)[C@H](C)[C@@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)CCC[C@H]([C@H]6C[C@H]6C)OC(=O)C[C@H]5[C@@H]4C=C(C)[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00005778_numbered.png2026-03-19 06:55:02.843809
12151214ML00008420C/C=C1\C[C@@H](C)[C@](O)(COC(C)=O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12161215ML00010906CC[C@H](O)[C@@H](C)[C@@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)[C@@H](C)[C@H](O)C[C@@H](O)[C@H](C)[C@H](OC(C)=O)/C=C\[C@H]1Cstandard_macrolactone12.0success7.0[3, 4, 7, 8, 9, 11, 12]ring_size_12/standard/numbered/ML00010906_numbered.png2026-03-19 06:55:02.900151
12171216ML00007569O=C(C[C@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)O[C@H](c2ccccc2)CNC1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12181217ML00006799COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OCC(NC(=O)[C@H](CO)NC(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12191218ML00002029CHEMBL3623743O=C(C#Cc1ccccc1)N/C=C/C[C@H]1C[C@@H](O)CC/C=C/Cc2cccc(C(F)F)c2C(=O)O1standard_macrolactone12.0success2.0[3, 5]ring_size_12/standard/numbered/ML00002029_numbered.png2026-03-19 06:55:02.944165
12201219ML00009100O=C(Oc1cc2c(c(O)c1O)-c1c(cc(O)c(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](O)[C@H](OC2=O)[C@@H]1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12211220ML00007457CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)NC[C@@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12221221ML00001770CHEMBL2152379O=C(C[C@@H]1C/C=C/CCC(=O)N[C@H](c2ccc(F)cc2)COC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12231222ML00007881C=C1C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@@](C)(O)[C@@H](C)[C@H]1C)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12241223ML00008488C=C1C/C(=C/C)C(=O)O[C@@H]2CC(=O)n3ccc(c32)COC(=O)[C@]1(C)OC(C)=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12251224ML00002092CHEMBL1552334CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N[C@H](C(C)(C)C)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12261225ML00008250C[C@H]1CCCCCCCc2cc(O)cc(O)c2C(=O)O1standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00008250_numbered.png2026-03-19 06:55:03.011618
12271226ML00002992O=C(N[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)COC1=O)OCC1c2ccccc2-c2ccccc21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12281227ML00003458CC[C@H]1CCC[C@@H](O[C@H]2CC[C@H](N)[C@H](C)O2)[C@H](C)C(=O)C2=C[C@H]3[C@H](C=C[C@H]4C[C@H](O[C@H]5O[C@H](C)[C@@H](OC)[C@H](OC)[C@H]5OC)C[C@@H]43)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00003458_numbered.png2026-03-19 06:55:03.057182
12291228ML00010301CC(=O)CCCCC(C)C1CC(O)C(C)C(=O)N[C@H](Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12301229ML00005776CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)[C@@H](O)[C@H]4C(C)=C[C@H]3[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00005776_numbered.png2026-03-19 06:55:03.104424
12311230ML00001633CHEMBL506817MALLOTUSINIC ACIDO=C1O[C@H]2[C@@H]3OC(=O)c4cc(Oc5c(C(=O)O)cc(O)c(O)c5O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]2C1=CC(=O)[C@](O)(O3)C2(O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12321231ML00009498COC(=O)Cc1c(C(=O)O[C@H]2[C@H](OC(=O)c3cc(O)c(O)c(O)c3)O[C@@H]3COC(=O)[C@@H]4[CH][C@@H](O)[C@@H](O)[C@@H](O)[C@H]4[C@H]4[C@H]([CH][C@H](O)[C@@H](O)[C@H]4O)C(=O)O[C@H]2[C@@H]3O)cc(O)c(O)c1Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12331232ML00002120CHEMBL432995ENTEROBACTINO=C(N[C@H]1COC(=O)[C@@H](NC(=O)c2cccc(O)c2O)COC(=O)[C@@H](NC(=O)c2cccc(O)c2O)COC1=O)c1cccc(O)c1Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12341233ML00008154COc1cc(O)cc2c1C(=O)O[C@H](C)CCCCC/C=C\2standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00008154_numbered.png2026-03-19 06:55:03.158673
12351234ML00002640CCC1CCCC(OC2CCC(N(C)C)C(C)O2)C(C)C(=O)C2=CC3C(C=CC4CC(OC5OC(C)C(OC)C(OC)C5OC)CC43)C2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002640_numbered.png2026-03-19 06:55:03.196138
12361235ML00010685CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12371236ML00010581CC/C=C/C=C/CC[C@]1(C)C[C@H](O)[C@H](C)CC[C@H]2C[C@@H](O[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]3OC)C[C@@](O)(CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12381237ML00009106O=C(Oc1cc(C(=O)O[C@@H]2O[C@@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]([C@H]2O)[C@@H]3O)cc(O)c1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12391238ML00004489CC(OC(=O)[C@H](C)NC(=O)c1cc(O)c(O)c(C(=O)N[C@H]2COC(=O)[C@@H](NC(=O)c3cccc(O)c3O)COC(=O)[C@@H](NC(=O)c3cccc(O)c3O)COC2=O)c1)OC(=O)N1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12401239ML00008192C[C@@H]1CCC[C@H](O)CC(=O)Cc2cc(O)cc(O)c2C(=O)O1standard_macrolactone12.0success3.0[3, 7, 9]ring_size_12/standard/numbered/ML00008192_numbered.png2026-03-19 06:55:03.262218
12411240ML00002342CC/C=C/[C@H]1CCC[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](OC)[C@H]2O)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002342_numbered.png2026-03-19 06:55:03.302574
12421241ML00007534C[C@H]1C[C@@H](C)C(=O)/C=C/[C@](C)(O)[C@@H]([C@@H](C)O)OC(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1Ostandard_macrolactone12.0success8.0[3, 4, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007534_numbered.png2026-03-19 06:55:03.353748
12431242ML00000024CHEMBL482050CC1CCC/C=C/C(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success2.0[3, 9]ring_size_12/standard/numbered/ML00000024_numbered.png2026-03-19 06:55:03.380382
12441243ML00001251CHEMBL1563338CC(C)(C)[C@H]1COC(=O)[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12451244ML00007771C/C=C1/CC[C@@](C)(O)C(=O)OC[C@@]2(O)CCN3CC[C@@H](OC1=O)[C@H]32non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12461245ML00010722CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(OC(C)=O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010722_numbered.png2026-03-19 06:55:03.437675
12471246ML00008409CC[C@H]1C[C@H](C)[C@](C)(OC(C)=O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12481247ML00010077CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N2CCC[C@@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12491248ML00010290C[C@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12501249ML00006724O=C(C[C@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@@H]2CCCN2C1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12511250ML00008936O=C(C[C@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O[C@@H](c2ccccc2)CNC1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12521251ML00007579O=C(O[C@H]1O[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@@H]2O)[C@H]1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12531252ML00010329CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@]2(CO2)[C@@H](O)/C=C\[C@@H]1Cstandard_macrolactone12.0success4.0[3, 4, 7, 11]ring_size_12/standard/numbered/ML00010329_numbered.png2026-03-19 06:55:03.513360
12541253ML00010118CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3O[C@@](O)(C2)[C@H](C)C(=O)O[C@@H](/C=C/C=C/Br)C/C(C)=C\C(=O)C3(C)C)[C@H](OC)[C@@H]1OC(N)=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12551254ML00004021O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]2C1=CC(=O)C(O)(O)[C@@]2(O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12561255ML00007541C[C@H]1C[C@@H](C)C(=O)/C=C/[C@@H](C)[C@@H]([C@@H](C)O)OC(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1Ostandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007541_numbered.png2026-03-19 06:55:03.577086
12571256ML00007793COc1cc(O)cc2c1C(=O)O[C@@H](C)CCC[C@@H](O)CCC2standard_macrolactone12.0success2.0[3, 7]ring_size_12/standard/numbered/ML00007793_numbered.png2026-03-19 06:55:03.606060
12581257ML00008470C/C=C1/C[C@@H](C)[C@@](C)(OC(C)=O)C(=O)OCc2ccn3c2[C@H](CC3=O)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12591258ML00007484Cc1c(O)cc(O)c2c1C(=O)OC[C@H](NC(=O)[C@@H]1[C@H](O)CCN1C(=O)[C@H](C)N)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)O)CSC2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12601259ML00007517CC(C)(C)[C@H]1COC(=O)CC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12611260ML00010076CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N2CCC[C@@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12621261ML00010842CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)C[C@@H](O)[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success7.0[3, 4, 7, 8, 8, 9, 11]ring_size_12/standard/numbered/ML00010842_numbered.png2026-03-19 06:55:03.683671
12631262ML00010099CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12641263ML00010480CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@]2(CO2)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success4.0[3, 4, 7, 11]ring_size_12/standard/numbered/ML00010480_numbered.png2026-03-19 06:55:03.729297
12651264ML00008055C[C@@H]1CCCCCC[C@H](O)/C=C\C(=O)O1standard_macrolactone12.0success2.0[3, 10]ring_size_12/standard/numbered/ML00008055_numbered.png2026-03-19 06:55:03.756920
12661265ML00007538CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C/[C@]1(C)Ostandard_macrolactone12.0success8.0[3, 4, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007538_numbered.png2026-03-19 06:55:03.812201
12671266ML00008572CC[C@H]1C[C@H](C)[C@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12681267ML00007169CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)NCCOC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12691268ML00007636C/C=C1\C(OC2OC(CO)C(O)C(O)C2O)OC=C2C(=O)OCC(C)C3CC(O)C(C)C3COC(=O)CC21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12701269ML00007309O=C(C[C@@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OCCNC1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12711270ML00008746C[C@@H]1[C@@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC(=O)[C@@]1(O)CO)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12721271ML00010169C[C@@H]1CCCCCCCc2cc(OCc3ccc([N+](=O)[O-])cc3)cc(OCc3ccc([N+](=O)[O-])cc3)c2C(=O)O1standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00010169_numbered.png2026-03-19 06:55:03.873230
12731272ML00009234CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@@H](NC=O)[C@@](C)(O)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12741273ML00007026COC(=O)[C@@H]1CSCc2c(OC)cc(O)c(C)c2C(=O)OCC(NC(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12751274ML00008623C[C@@H]1O[C@@]12C[C@H](C)[C@@](C)(O)C(=O)OCC1=CCN3CC[C@@H](OC2=O)[C@H]13non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12761275ML00007110C[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12771276ML00009338CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12781277ML00007878C=C1C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@H](C)[C@H]1C)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12791278ML00010483CC(C)(C)[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12801279ML00006881CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@@]3(C[C@H]1C)O[C@H]3C)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12811280ML00001160CHEMBL3260947CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)/C=C\CCc3coc(C=C(C)C)n3)C[C@H](CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12821281ML00008583C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2[C@H](O)CN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12831282ML00007248CO[C@H]1/C=C\CC/C=C\C(=O)O[C@H](/C(C)=C/[C@H](C)C(=O)/C=C/CC2CC(=O)NC(=O)C2)[C@@H](C)[C@@H]1Ostandard_macrolactone12.0success4.0[3, 4, 5, 6]ring_size_12/standard/numbered/ML00007248_numbered.png2026-03-19 06:55:03.979861
12841283ML00010149C[C@@H]1CCCCCCCc2cc(OC(=O)c3ccccc3)cc(OC(=O)c3ccccc3)c2C(=O)O1standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00010149_numbered.png2026-03-19 06:55:04.003727
12851284ML00007867C/C=C1/C[C@@]2(CO)O[C@@]2(C)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12861285ML00008205CC1CCC(=O)CCCCc2cc(O)cc(O)c2C(=O)O1standard_macrolactone12.0success2.0[3, 6]ring_size_12/standard/numbered/ML00008205_numbered.png2026-03-19 06:55:04.037437
12871286ML00008260C/C=C1/C[C@H](CO)[C@@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12881287ML00008601C[C@@H]1C[C@]2(C)CC(=O)O[C@@H]3CCN4CC[C@H](COC(=O)[C@]1(C)O2)[C@H]34non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12891288ML00002228O=C(N[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=O)OCC1c2ccccc2-c2ccccc21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12901289ML00005118O=C1O[C@H]2[C@H]3COC(=O)c4cc(Oc5c(C(=O)O[C@@H]6O[C@H]7COC(=O)c8cc(O)c(O)c(O)c8-c8c(cc(O)c(O)c8O)C(=O)O[C@H]7[C@H](OC(=O)c7cc(O)c(O)c(O)c7)[C@H]6OC(=O)c6cc(O)c(O)c(O)c6)cc(O)c(O)c5O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]2[C@@H](OC(=O)c2cc(O)c(O)c4c2[C@@H]2C1=CC(=O)C(O)(O)[C@@]2(O)O4)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12911290ML00008051C[C@@H]1CCCCCC/C=C\CC(=O)O1standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00008051_numbered.png2026-03-19 06:55:04.097473
12921291ML00008212C[C@@H]1CCC(=O)[C@@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success4.0[3, 6, 7, 9]ring_size_12/standard/numbered/ML00008212_numbered.png2026-03-19 06:55:04.132937
12931292ML00005752CC[C@H](C)[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@H]4C(C)=C[C@H]3[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00005752_numbered.png2026-03-19 06:55:04.172780
12941293ML00007918C=C1C/C(=C/C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@@]1(C)O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12951294ML00010417C[C@@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12961295ML00010069CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N2CCC[C@@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12971296ML00008591C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@@H]2CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
12981297ML00007535CC[C@H]1OC(=O)[C@@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@H](C)C(=O)/C=C\[C@@]1(C)Ostandard_macrolactone12.0success8.0[3, 4, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007535_numbered.png2026-03-19 06:55:04.253424
12991298ML00007462CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)NC[C@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13001299ML00008428C/C=C1/C[C@@H](C)[C@@](C)(OC(C)=O)C(=O)OC[C@H]2[C@H](O)CN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13011300ML00007849COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OC[C@@H](C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13021301ML00007638C/C=C1/[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OC[C@H](C)[C@]3(O)CC[C@H](C)[C@H]3COC(=O)C[C@H]21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13031302ML00001174CHEMBL2381160CC(=O)Nc1ccc(O)cc1CCCC[C@@H]1C[C@@H]2C[C@@]3(O[C@H](CCC3(C)C)CC(=O)O[C@@H](CO)CC(=O)O2)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13041303ML00008065C[C@H]1C/C=C\CCCCCCC(=O)O1standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00008065_numbered.png2026-03-19 06:55:04.312395
13051304ML00006375O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]3[C@H]1OC(=O)c1cc(O)c(O)c4c1C1C5(C[C@]6(O)OC[C@@H](O)[C@@H]6C[C@@H]5C(O)(O)C(O)(O)[C@]1(O)O4)C(=O)O[C@@H]32)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13061305ML00006934COc1cc(O)c2c(c1C)C(=O)OC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](C(=O)O)CSC2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13071306ML00008635C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13081307ML00008619C/C=C1/C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13091308ML00008315C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@@H](C2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13101309ML00007997C[C@H]1CCC/C=C\[C@H]2CC[C@H](O)[C@@H](CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13111310ML00002105CHEMBL2420696CC[C@H](OC)[C@@H](C)[C@H]1O[C@@H]1[C@@H](O)[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00002105_numbered.png2026-03-19 06:55:04.396057
13121311ML00001721CHEMBL37203CC(C)[C@@H]1OC(=O)[C@@H](C)[C@@H](C)OC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13131312ML00008614C/C=C1/C[C@H](C)[C@@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13141313ML00000647CHEMBL1725065O=C(N[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=O)OCC1c2ccccc2-c2ccccc21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13151314ML00008580C/C=C1/C[C@@H](C)[C@](C)(O)C(=O)OC[C@H]2[C@H](O)CN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13161315ML00002403CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5O)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002403_numbered.png2026-03-19 06:55:04.458945
13171316ML00004208O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2OC(=O)[C@H]1CC(=O)c2oc(=O)c3cc(O)c(O)c(O)c3c21)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13181317ML00003369O=C(C[C@@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13191318ML00006620CC(=O)O[C@H](C)[C@@]1(O)C[C@@H](C)[C@@](C)(OC(C)=O)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC1=O)[C@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13201319ML00005116O=C1O[C@H]2[C@@H]3COC(=O)c4cc(Oc5c(C(=O)O[C@@H]6[C@@H](OC(=O)c7cc(O)c(O)c(O)c7)O[C@@H](COC(=O)c7cc(O)c(O)c(O)c7)[C@@H](OC(=O)c7cc(O)c(O)c(O)c7)[C@H]6OC(=O)c6cc(O)c(O)c(O)c6)cc(O)c(O)c5O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@@H]2[C@H](C(=O)Oc2cc(O)c(O)c4c2[C@@H]2C1=CC(=O)[C@](O)(O4)C2(O)O)[C@@H](OC(=O)c1cc(O)c(O)c(O)c1)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13211320ML00007411O=C(O)C[C@@H]1C(=O)O[C@@H]2[C@@H](COC(=O)c3cc4c(c(O)c3O)OC(=O)[C@H]41)O[C@@H](OC(=O)/C=C\c1ccc(O)c(O)c1)[C@H](O)[C@H]2Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13221321ML00009133O=C1O[C@@H](c2ccccc2)CNC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@H]1Cc1ccc(F)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13231322ML00008651C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13241323ML00007540C[C@H](O)[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1Cstandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007540_numbered.png2026-03-19 06:55:04.579790
13251324ML00009105O=C1O[C@@H]2[C@@H]3COC(=O)C4=CC(=O)[C@]5(O)Oc6c(O)c(O)cc(c6[C@H]4C5(O)O)C(=O)O[C@H]2[C@H](OC(=O)c2cc(O)c(O)c4c2[C@@H]2C1=CC(=O)[C@](O)(O4)C2(O)O)[C@H](O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13261325ML00007000C[C@@H]1C(=O)O[C@@H]2CC(=O)n3ccc(c32)COC(=O)[C@]2(C)CCOC(=O)[C@]2(C)[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13271326ML00000998CHEMBL290049CCCCCCC[C@H]1OC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C(=O)COC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13281327ML00000115CHEMBL3087767COC(=O)[C@H](O)CS[C@H]1CCC[C@H](C)OC(=O)Cc2cc(O)cc(O)c2C(=O)C1standard_macrolactone12.0success3.0[3, 7, 9]ring_size_12/standard/numbered/ML00000115_numbered.png2026-03-19 06:55:04.634097
13291328ML00009162CCC[C@H](O)[C@@H](C)C(=O)NC/C=C\C[C@H](C)[C@H](O)[C@H](C)[C@@H]1C/C=C\C[C@H](C)[C@H](O)Cc2cc(OC)cc(O)c2C(=O)O1standard_macrolactone12.0success3.0[3, 8, 9]ring_size_12/standard/numbered/ML00009162_numbered.png2026-03-19 06:55:04.666149
13301329ML00008628C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13311330ML00006895CC(=O)C[C@@H](O)CC(=O)[C@@H]1OC(=O)CCCCCCCc2ccccc21standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00006895_numbered.png2026-03-19 06:55:04.696893
13321331ML00004282CC[C@H]1CCC[C@H](O[C@@H]2CC[C@@H](NC)[C@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@H]4C[C@H](O[C@@H]5O[C@H](C)[C@H](OC)[C@H](OC)[C@@H]5OC)C[C@@H]4C=C[C@@H]3[C@H]2CC(=O)O1standard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00004282_numbered.png2026-03-19 06:55:04.732587
13331332ML00002050CHEMBL2152365C[C@H]1[C@@H](c2ccccc2)OC(=O)CCCCC[C@@H](CC(=O)NCc2ccc(Cl)cc2)C(=O)N1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13341333ML00007915C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCc2ccn3c2[C@@H](CC3=O)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13351334ML00002321COC(=O)[C@H]1OC(=O)c2cc(O)c(O)c(O)c2[C@@H]1[C@H](CC(=O)O)C(=O)O[C@@H]1[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@@H](O)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13361335ML00008041O=C1CCC=CCCOC(=O)c2c(O)cc(O)c(Cl)c2C1standard_macrolactone12.0success1.0[9]ring_size_12/standard/numbered/ML00008041_numbered.png2026-03-19 06:55:04.779572
13371336ML00008640C/C=C1/C[C@@H](C)[C@H](O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13381337ML00008244C[C@@H]1C[C@H](O)CCCCCc2cc(O)cc(O)c2C(=O)O1standard_macrolactone12.0success2.0[3, 5]ring_size_12/standard/numbered/ML00008244_numbered.png2026-03-19 06:55:04.812731
13391338ML00004049O=C(O)/C=C(/C(=O)O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@@H](O)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O2)[C@H]1c2c(cc(O)c(O)c2O)C(=O)O[C@@H]1C(=O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13401339ML00007832CC[C@H]1OC(=O)[C@@H](C)[C@@H](O)[C@@H](C)C[C@H](C)C(=O)/C=C\[C@@]1(C)Ostandard_macrolactone12.0success8.0[3, 4, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007832_numbered.png2026-03-19 06:55:04.869375
13411340ML00003837O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]3[C@H]2OC(=O)c2cc(O)c(O)c4oc5c(O)c(O)cc(c5c24)C(=O)O[C@@H]13)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13421341ML00008579C/C=C1/CC(C)C(C)(O)C(=O)OCC2C(O)CN3CCC(OC1=O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13431342ML00010236CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@](C)(O)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010236_numbered.png2026-03-19 06:55:04.925570
13441343ML00006761C[C@H](N)C(=O)N1CC[C@@H](O)[C@H]1C(=O)N[C@H]1COC(=O)c2cc(O)cc(O)c2CSC[C@@H](C(=O)N[C@@H](C)C(=O)O)NC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13451344ML00011031CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H](CO)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cccc(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13461345ML00008077C[C@H]1CCC/C=C\C/C=C\CC(=O)O1standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00008077_numbered.png2026-03-19 06:55:04.964972
13471346ML00002846C=C[C@H]1[C@@H]2[C@@H]3/C=C\CC(=O)O[C@@]45C[C@@H](C)[C@@]6(O)[C@@H](C=C(CO)C[C@]7(O)C(=O)C(C)=C[C@H]76)[C@@H]4[C@@]5(C)COC(=O)[C@H]3[C@@H](/C=C/C=C/C=C/C=C/CCC)[C@H]12non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13481347ML00008534C/C=C1\C[C@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13491348ML00002114CHEMBL1562866CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13501349ML00001844CHEMBL1080988O=C(C[C@H]1C/C=C/CCC(=O)OCCNC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13511350ML00007854COc1cc2c(c(OC)c1)C(=O)O[C@H](C)CCCC/C=C/C2standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00007854_numbered.png2026-03-19 06:55:05.016752
13521351ML00005777CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@H]3[C@@H]4C=C5C(=O)[C@H](C)[C@@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)CCC[C@H](C6CCC6)OC(=O)C[C@H]5[C@@H]4C=C(C)[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00005777_numbered.png2026-03-19 06:55:05.053994
13531352ML00007785C[C@@H]1C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@H](O)[C@@H](C)[C@H]1C)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13541353ML00008918O=C1OC[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@H]1Cc1ccc(F)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13551354ML00007254CO[C@H]1/C=C/CC/C=C/C(=O)O[C@@H](/C(C)=C/[C@H](C)C(=O)/C=C/CC2CC(=O)NC(=O)C2)[C@@H](C)[C@@H]1Ostandard_macrolactone12.0success4.0[3, 4, 5, 6]ring_size_12/standard/numbered/ML00007254_numbered.png2026-03-19 06:55:05.104741
13561355ML00008584C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OC[C@H]2[C@H](O)CN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13571356ML00008588C/C=C1/C[C@@H](C)[C@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13581357ML00008672C/C=C1/C(=O)O[C@@H]2CCN3CC[C@H](COC(=O)[C@](C)(O)[C@H](C)[C@H]1O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13591358ML00002227O=C(C[C@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O[C@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13601359ML00000584CHEMBL1726132O=C(N[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=O)OCC1c2ccccc2-c2ccccc21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13611360ML00007976COc1cc(O)cc2c1C(=O)O[C@H](C)CCCCCCC2standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00007976_numbered.png2026-03-19 06:55:05.164323
13621361ML00006971COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OC[C@H](NC(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13631362ML00010877CC[C@H](O)[C@H](C)[C@H](O)[C@H](O)C[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010877_numbered.png2026-03-19 06:55:05.212753
13641363ML00001143CHEMBL3347530CCCCCCCCCCC[C@]1(CO)CCCC(=O)O[C@](CO)(CCCCCCCCCCC)CCCC(=O)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13651364ML00008266C/C=C1\C[C@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3(C)CC[C@H](OC1=O)[C@@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13661365ML00007252CC[C@H](C)[C@H]1OC(=O)[C@@H](NC(=O)c2cccc(O)c2O)[C@@H](C)OC(=O)C(C)(C)C(=O)[C@@H](CC(C)C)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13671366ML00007977COc1cc(O)cc2c1C(=O)OC(C)CCCCCCC2standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00007977_numbered.png2026-03-19 06:55:05.257985
13681367ML00002635CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](CSC)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002635_numbered.png2026-03-19 06:55:05.306378
13691368ML00000112CHEMBL3087769C[C@H]1CCC[C@H](SC[C@@H](O)C(=O)O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success3.0[3, 7, 9]ring_size_12/standard/numbered/ML00000112_numbered.png2026-03-19 06:55:05.338214
13701369ML00004019O=C1OC2C3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC2C(OC(=O)c2cc(O)c(O)c4c2C2C1=CC(=O)C(O)(O)C2(O)O4)C(OC(=O)c1cc(O)c(O)c(O)c1)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13711370ML00007433CC/C=C\C=C/C(=O)N/C=C/C[C@H]1C[C@@H](O)[C@@H](C)C/C=C/Cc2cccc(O)c2C(=O)O1standard_macrolactone12.0success3.0[3, 5, 6]ring_size_12/standard/numbered/ML00007433_numbered.png2026-03-19 06:55:05.376943
13721371ML00004659CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(=O)NCCOCCOCCNC(=O)CCCCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)/C=C/[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00004659_numbered.png2026-03-19 06:55:05.420740
13731372ML00010324CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@@H]3CC[C@@H](C)[C@H](O)C[C@@](C)(/C=C/C=C/Br)OC(=O)C[C@](O)(C2)O3)[C@H](OC)[C@@H]1OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13741373ML00001867CHEMBL1442330CC(=O)O[C@]1(C)C(=O)OC/C2=C/CN(C)CCC(OC(=O)[C@@](O)(C(C)O)C[C@H]1C)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13751374ML00008162CO[C@@H]1CCC[C@@H](C)OC(=O)c2c(O)cc(O)cc2CC(=O)C1standard_macrolactone12.0success3.0[3, 7, 9]ring_size_12/standard/numbered/ML00008162_numbered.png2026-03-19 06:55:05.464028
13761375ML00000274CHEMBL3220169CC(=O)O[C@H]1/C=C/C[C@@H](/C(C)=C/C=C/CC[C@H]2O[C@@H]2C[C@H](C)O[Si](C)(C)C(C)(C)C)OC(=O)CCCC[C@@]1(C)Ostandard_macrolactone12.0success4.0[3, 7, 8, 8]ring_size_12/standard/numbered/ML00000274_numbered.png2026-03-19 06:55:05.498403
13771376ML00007539C[C@H]1C[C@@H](C)C(=O)/C=C\[C@@H](C)[C@@H]([C@@H](C)O)OC(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1Ostandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/ML00007539_numbered.png2026-03-19 06:55:05.542367
13781377ML00009124O=C(Oc1cc2c(c(O)c1O)-c1c(cc(O)c(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](O)[C@@H](OC2=O)[C@@H]1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13791378ML00008118COC(=O)C(O)CSC1CC(=O)OC(C)CCCCCC(O)C1=Ostandard_macrolactone12.0success4.0[3, 9, 10, 11]ring_size_12/standard/numbered/ML00008118_numbered.png2026-03-19 06:55:05.583003
13801379ML00010180C[C@H]1COC(=O)[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13811380ML00007175CO[C@H]1/C=C\CC/C=C\C(=O)O[C@H](/C(C)=C/[C@H](C)C(=O)C[C@H](O)CC2CC(=O)NC(=O)C2)[C@@H](C)[C@@H]1Ostandard_macrolactone12.0success4.0[3, 4, 5, 6]ring_size_12/standard/numbered/ML00007175_numbered.png2026-03-19 06:55:05.623583
13821381ML00010841CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1[C@H](O)[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010841_numbered.png2026-03-19 06:55:05.665464
13831382ML00007649C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\[C@H](O)C[C@@H]1Cstandard_macrolactone12.0success3.0[3, 4, 6]ring_size_12/standard/numbered/ML00007649_numbered.png2026-03-19 06:55:05.696667
13841383ML00008423CC(=O)O[C@@]1(C)C(=O)OCC2=CCN3CC[C@@H](OC(=O)[C@@]4(C[C@@H]1C)O[C@H]4C)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13851384ML00002065CHEMBL3623740O=C(C#Cc1ccccc1)N/C=C/C[C@H]1C[C@@H](O)CC/C=C/Cc2cccc(F)c2C(=O)O1standard_macrolactone12.0success2.0[3, 5]ring_size_12/standard/numbered/ML00002065_numbered.png2026-03-19 06:55:05.729697
13861385ML00008478COc1cc(O)c2c(c1OC)/C=C\C[C@@H]1O[C@H](CC(=O)[C@H]1O)C[C@H](C)OC2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13871386ML00007772C/C=C1/CC[C@@](C)(O)C(=O)OC[C@@]2(O)CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13881387ML00006973COC(=O)[C@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OC[C@H](NC(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13891388ML00008646C/C=C1\CC(C)C(O)(CO)C(=O)OCC2=CC[N+]3([O-])CCC(OC1=O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13901389ML00006847CCCC(=O)Oc1cc2c(c(OC(=O)CCC)c1)C(=O)O[C@H](C)CCCCCCC2standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00006847_numbered.png2026-03-19 06:55:05.777387
13911390ML00008194CC1CCCC(O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success3.0[3, 7, 9]ring_size_12/standard/numbered/ML00008194_numbered.png2026-03-19 06:55:05.806233
13921391ML00007877C=C1C(=O)OC2CCN3CC=C(COC(=O)C(C)(O)C(C)C1C)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13931392ML00002701CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@H]3[C@@H]4C=C5C(=O)[C@H](C)[C@@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)CCC[C@H](C(C)C)OC(=O)C[C@H]5[C@@H]4C=C(C)[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success4.0[3, 7, 8, 9]ring_size_12/standard/numbered/ML00002701_numbered.png2026-03-19 06:55:05.847931
13941393ML00000293CHEMBL507308PUNICAFOLINO=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@H]1OC(=O)c1cc(O)c(O)c(O)c1)[C@@H]2OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13951394ML00010605O=C1CC/C=C/CCC(=O)N(Cc2cccc(C=NNC(=O)c3cccc(C(=O)NO)c3)c2)C[C@H](c2ccccc2)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13961395ML00006788COc1ccc(C(=O)N[C@@H]2C(=O)NCC(=O)N[C@H](Cc3ccc(O)cc3)[C@@H](O)CC(=O)O[C@@H]2C)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13971396ML00009236CO[C@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@H](C)O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cccc(OC(C)=O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13981397ML00002986C=C1C[C@@]23OC(=O)C/C=C\[C@H]4[C@H]5[C@H](/C=C/CC)[C@H]5[C@H](c5cc(OC)c6c(c5)OCO6)[C@@H]4C(=O)OC[C@]2(C)[C@H]3[C@@H]2C=C(CO)C[C@@H]3C(=O)C(C)=C[C@H]3[C@@]12Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
13991398ML00008421C/C=C1/C[C@@H](COC(C)=O)[C@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14001399ML00009665CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14011400ML00004603CC(OC(=O)[C@@H](NC(=O)c1cc(O)c(O)c(C(=O)N[C@H]2COC(=O)[C@@H](NC(=O)c3cccc(O)c3O)COC(=O)[C@@H](NC(=O)c3cccc(O)c3O)COC2=O)c1)C(C)C)OC(=O)N1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14021401ML00008066C[C@H]1CCCC/C=C\CCCC(=O)O1standard_macrolactone12.0success1.0[3]ring_size_12/standard/numbered/ML00008066_numbered.png2026-03-19 06:55:05.929272
14031402ML00004055O=C(O)C[C@]1(O)C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]1[C@H](O)C(=O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14041403ML00007948C=C1C/C(=C\C)C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@@]1(C)O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14051404ML00010551O=C(C[C@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@H]2CCCN2C1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14061405ML00001711CHEMBL2152378CC(C)[C@@H]1COC(=O)[C@H](CC(=O)NCc2ccc(Cl)cc2)C/C=C/CCC(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14071406ML00008213C[C@@H]1C[C@H](O)C/C=C\C(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success3.0[3, 5, 9]ring_size_12/standard/numbered/ML00008213_numbered.png2026-03-19 06:55:05.985007
14081407ML00008772CC[C@@H]1C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@@H](C)[C@H]1O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14091408ML00010865CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@@H]3CC[C@@H](C)[C@H](O)C[C@@](C)(CC/C=C/C=C/Br)OC(=O)C[C@](O)(C2)O3)[C@H](OC)[C@@H]1OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14101409ML00001120CHEMBL1711599CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14111410ML00004040O=C1C=C2C(=O)O[C@H]3[C@H](OC(=O)c4cc(O)c(O)c(O)c4)O[C@@H]4COC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)O[C@H]3[C@@H]4OC(=O)c3cc(O)c(O)c(O)c3[C@H]2C(=O)C1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14121411ML00009992CCCCCCC[C@H]1OC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)CC)OC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14131412ML00006819O=C(C[C@@H]1C/C=C\CCC(=O)OC[C@@H]2CCCN2C1=O)N[C@@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14141413ML00001577CHEMBL1722114O=C(N[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)COC1=O)OCC1c2ccccc2-c2ccccc21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14151414ML00008607C/C=C1/C[C@@H](CO)[C@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14161415ML00008663C/C=C1/C[C@@H](C)[C@](C)(O)C(=O)OCC2=CCN3C[C@H](O)[C@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14171416ML00008924O=C1OC[C@H](Cc2ccccc2)NC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@H]1Cc1ccc(F)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14181417ML00010310CC[C@H]1O[C@]1(C)[C@H](O)[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/ML00010310_numbered.png2026-03-19 06:55:06.093726
14191418ML00008199C[C@H]1CCCC(O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0success3.0[3, 7, 9]ring_size_12/standard/numbered/ML00008199_numbered.png2026-03-19 06:55:06.123352
14201419ML00008775C/C=C1\C(=O)O[C@@H]2CCN3CC[C@H](COC(=O)[C@@](C)(O)[C@@H](C)[C@@H]1O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14211420ML00010507O=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14221421ML00007198CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14231422ML00002003CHEMBL1710668O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14241423ML00007370C[C@H]1CCC/C=C/[C@@H]2C[C@H](OC(=O)CCCC(=O)NCCCCCCO)C[C@H]2[C@H](O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00007370_numbered.png2026-03-19 06:55:06.174619
14251424ML00002708CO[C@@H]1[C@H](O[C@H]2[C@H](OC)CO[C@@H](O[C@H]3C[C@H]4CC(=O)[C@@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)[C@@H]2OC)O[C@@H](C)[C@@H](O)[C@@H]1OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14261425ML00007206CCCCC(C)CC1NC(=O)C(C)NC(=O)C(Cc2ccccc2)NC(=O)CC(C(C)C)OC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14271426ML00006699C[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C\C[C@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14281427ML00004153CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)C(C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([N+](C)(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14291428ML00010043C/C=C1\NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)N[C@H](C)C(C)=O)[C@@H](C)OC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14301429ML00007775CO[C@@H]1/C=C/C(=O)O[C@@H](C)CCC/C=C\[C@@H]2C[C@H](O)C[C@H]21standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00007775_numbered.png2026-03-19 06:55:06.235343
14311430ML00007020C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([Se]c2ccccc2)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00007020_numbered.png2026-03-19 06:55:06.266647
14321431ML00008035O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCCCO1standard_macrolactone13.0success1.0[11]ring_size_13/standard/numbered/ML00008035_numbered.png2026-03-19 06:55:06.298705
14331432ML00008922O=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14341433ML00010091CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc2ccccc2)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14351434ML00003696CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14361435ML00010446COc1ccc(C[C@H]2NC(=O)[C@]34OC(=O)O/C=C\[C@](C)(O)C(=O)[C@H](C)C/C=C\[C@@H]3[C@@H](O)C(C)=C(C)[C@H]24)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14371436ML00005335CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14381437ML00001889CHEMBL383015RADANAMYCINCOc1c(O)cc2c(O)c1CC(C)OC(=O)c1c(O)cc(O)c(Cl)c1CCC(=O)N2non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14391438ML00005336CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14401439ML00008253C[C@H]1CCC/C=C\[C@@H]2CC(=O)C[C@H]2[C@H](O)/C=C\C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008253_numbered.png2026-03-19 06:55:06.381786
14411440ML00005216CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14421441ML00002237C/C=C1\CC(c2cc(CO)cc(NCC(O)C3CCCCC3)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00002237_numbered.png2026-03-19 06:55:06.425906
14431442ML00007197CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14441443ML00008025O=C1CCC/C=C\CCOC(=O)c2c(O)cc(O)c(Cl)c2C1standard_macrolactone13.0success1.0[10]ring_size_13/standard/numbered/ML00008025_numbered.png2026-03-19 06:55:06.456908
14451444ML00010505O=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14461445ML00001877CHEMBL1079179COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)/C=C\[C@H](C)[C@H](C)OC2=Ostandard_macrolactone13.0success4.0[3, 4, 7, 8]ring_size_13/standard/numbered/ML00001877_numbered.png2026-03-19 06:55:06.500225
14471446ML00003513CC(C)CCCCCCCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H]1COC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)[C@@H](C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14481447ML00006700COc1ccc(S[C@@H]2CC(=O)O[C@@H](C)CCC/C=C/[C@@H]3C[C@H](O)C[C@H]3[C@@H]2O)cc1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00006700_numbered.png2026-03-19 06:55:06.537413
14491448ML00007875C/C1=C/C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@H](C)C1)[C@H]23non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14501449ML00009519CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H]([C@H](C)O)[C@@](C)(O)[C@H](O)[C@@H](C)C3=C(C)C[C@@]2(C)O3)[C@@H]1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14511450ML00008087C[C@@H]1C/C(CO)=C\CC(=O)O[C@H](C)C/C=C\C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14521451ML00008554CC(=O)O[C@@H]1/C=C/C(=O)O[C@@H](C)CCC/C=C\[C@@H]2C[C@H](O)C[C@H]21standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008554_numbered.png2026-03-19 06:55:06.583692
14531452ML00010668CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14541453ML00002236C/C=C1\CC(c2cc(CO)cc(NCC(C)(O)CCOC)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00002236_numbered.png2026-03-19 06:55:06.622980
14551454ML00010663CCCC[C@H](C)[C@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14561455ML00010680CC(C)(C)[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14571456ML00008331COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)/C=C\[C@H](C)[C@@H](C)OC2=Ostandard_macrolactone13.0success4.0[3, 4, 7, 8]ring_size_13/standard/numbered/ML00008331_numbered.png2026-03-19 06:55:06.668490
14581457ML00002502C/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCC3CCC4CC(=O)CC3C42)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00002502_numbered.png2026-03-19 06:55:06.701532
14591458ML00010981CC(C)CCC[C@H]1CC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14601459ML00008147C[C@H]1CCC/C=C\[C@@H]2C[C@@H](O)C[C@H]2[C@H](O)/C=C\C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008147_numbered.png2026-03-19 06:55:06.734147
14611460ML00002254CCNCC/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00002254_numbered.png2026-03-19 06:55:06.767512
14621461ML00010924CCCCCC(CC(=O)N1N=CCCC1C(=O)N[C@H]1COC(=O)[C@H]2CCCNN2C(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)NC1=O)C(=O)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14631462ML00000138CHEMBL26966CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14641463ML00008862CCCCCC[C@H](C)[C@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14651464ML00004152CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)C(C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([N+](C)(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14661465ML00008440CC1CCCC=CC2CC(OC(=O)CN(C)C)CC2C(O)C=CC(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008440_numbered.png2026-03-19 06:55:06.824471
14671466ML00006716Nc1ccc(CC[C@H]2CCC/C=C/[C@@H]3C[C@H](O)C[C@H]3[C@H](O)/C=C/C(=O)O2)cc1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00006716_numbered.png2026-03-19 06:55:06.851651
14681467ML00010993CCCCCC[C@@H](C)[C@@H]1OC(=O)[C@H](CO)NC(=O)[C@H](C(=O)c2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14691468ML00000997CHEMBL1087150O=C(C[C@H]1C/C=C/CCCC(=O)O[C@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14701469ML00005386CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC/N=C(\N(C)C)N2CCOCC2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14711470ML00005381CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14721471ML00007295O=C1CCC/C=C/C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14731472ML00010426COc1ccc(C[C@H]2NC(=O)[C@]34OC(=O)O/C=C\[C@@](C)(O)C(=O)[C@@H](C)C/C=C\[C@H]3[C@H]3O[C@@]3(C)[C@@H](C)[C@H]24)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14741473ML00009533CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@](C)(O)C[C@@H](C)C2=C(C)C(=O)[C@@]1(C)O2non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14751474ML00010144C[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14761475ML00007305O=C(C[C@H]1C/C=C/CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H](c2ccccc2)NC1=O)NCCOnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14771476ML00003365C/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00003365_numbered.png2026-03-19 06:55:06.955434
14781477ML00003704CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)C[C@H](C)[C@H](O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14791478ML00007882C/C1=C/C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@H](C)C1)[C@H]23non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14801479ML00000025CHEMBL1987060CC1CCC/C=C/C2CC(O)CC2C(O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00000025_numbered.png2026-03-19 06:55:07.001531
14811480ML00005364CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14821481ML00002267C/C=C1\CC(c2cc(CO)c(CCCCC)c(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00002267_numbered.png2026-03-19 06:55:07.049168
14831482ML00009781CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14841483ML00007005CC(=O)C[C@H](O)CC(=O)[C@@H]1OC(=O)CCCCCCCCc2ccccc21standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00007005_numbered.png2026-03-19 06:55:07.079390
14851484ML00006815COC(=O)c1ccccc1S[C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1Ostandard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00006815_numbered.png2026-03-19 06:55:07.110995
14861485ML00007019C=C1/C=C\[C@@H]([C@H](C)C(=C)C)OC(=O)C[C@]2(O)O[C@@H](CC(=C)[C@H]2C)[C@@H]2O[C@H]2C1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14871486ML00008920O=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14881487ML00008861CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C[C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14891488ML00010172C[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14901489ML00006684CCCCCCCCO[C@H]1O[C@@H]2COC(=O)CCCCCCC(=O)O[C@H]2[C@H](O)[C@H]1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14911490ML00002095CHEMBL327709CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CNC(=O)CCCOC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14921491ML00008570CCC1CC(C)C(O)(CO)C(=O)OCC2=CCN3CC(CC23)OC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14931492ML00006774O=C1CCC/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@@H]2CO1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14941493ML00006947C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])CCN(C)C)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00006947_numbered.png2026-03-19 06:55:07.194487
14951494ML00001967CHEMBL1933479CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](CO)C(=O)N[C@H](C2CCCCC2)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14961495ML00008553CC(=O)O[C@H]1C[C@H]2/C=C/CCC[C@H](C)OC(=O)/C=C/[C@@H](O)[C@@H]2C1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008553_numbered.png2026-03-19 06:55:07.227751
14971496ML00000996CHEMBL1088172O=C(C[C@@H]1C/C=C/CCCC(=O)O[C@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14981497ML00002062CHEMBL4087980COC(=O)Nc1ccc2c(c1)NC(=O)OC/C=C/C[C@H](NC(=O)/C=C/c1cc(Cl)ccc1-n1cnnn1)c1nc-2c[nH]1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
14991498ML00006793CCCCCCCCO[C@H]1O[C@@H]2COC(=O)CC/C=C/CCC(=O)O[C@H]2[C@H](OC)[C@H]1OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15001499ML00005349CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15011500ML00001374CHEMBL2158215CCCCCCCCCCCCC[C@H]1OC(=O)[C@H](COCc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15021501ML00002063CHEMBL4082071COC(=O)Nc1ccc2c(c1)NC(=O)OCCCC[C@H](NC(=O)/C=C/c1cc(Cl)ccc1-n1cnnn1)c1nc-2c[nH]1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15031502ML00007194CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15041503ML00007202CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H](CC(C)C)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15051504ML00009241NC(=O)C[C@H]1NC(=O)[C@H](CCCN(O)C=O)NC(=O)[C@H](NC(=O)C[C@H](O)[C@@H](N)CCCCNC(=O)c2cccc(O)c2O)COC(=O)[C@H](CCCN(O)C=O)NC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15061505ML00003697CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15071506ML00007713C[C@@H]1C[C@H](O)[C@@H]2C=C[C@H](CC(=O)Cc3c(Cl)c(O)cc(O)c3C(=O)O1)O2non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15081507ML00007193CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15091508ML00010501O=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15101509ML00003233CC(C)CC/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00003233_numbered.png2026-03-19 06:55:07.354519
15111510ML00002005CHEMBL1717692O=C1NC[C@@H](c2ccccc2)OC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15121511ML00008222CC1CCC/C=C/C2CC(=O)CC2C(O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008222_numbered.png2026-03-19 06:55:07.386611
15131512ML00001750CHEMBL1081726O=C(C[C@H]1C/C=C/CCCC(=O)O[C@@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15141513ML00008512CC/C=C\C[C@H]1/C=C\[C@H]2C=CC(=O)[C@@H]2C/C=C\CCCC(=O)O1standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00008512_numbered.png2026-03-19 06:55:07.414749
15151514ML00006665O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCC[C@H](CCc2ccc(F)cc2)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00006665_numbered.png2026-03-19 06:55:07.440609
15161515ML00001140CHEMBL1715575O=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)O[C@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15171516ML00010657CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15181517ML00007287CC1=C2[C@H](Cc3ccccc3)NC(=O)[C@]23OC(=O)O/C=C\[C@](C)(O)C(=O)[C@H](C)C/C=C\[C@@H]3[C@H](O)[C@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15191518ML00000121CHEMBL300004CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15201519ML00003821C=CC[N+](C)(C)[C@@H]1C[C@@H](C)O[C@@H](O[C@@H]2C(C)C(O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@@H](C)O3)C(C)C(=O)OC(CC)[C@@](C)(O)[C@H](O)[C@@H](C)C3=C(C)C[C@]2(C)O3)[C@@H]1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15211520ML00010479O=C1CCC/C=C/C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)CO1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15221521ML00008881O=C1O[C@@H](c2ccccc2)CNC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C/CC[C@H]1Cc1ccc(F)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15231522ML00003705CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CCO)[C@H]2O)[C@@]2(C)C[C@H](C)[C@H](O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15241523ML00008302CC(C)(C)[C@H]1COC(=O)CCC/C=C/C[C@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15251524ML00008306C[C@H](O)C[S+]([O-])[C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1Ostandard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00008306_numbered.png2026-03-19 06:55:07.535541
15261525ML00004154CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@]2(C)C[C@H](C)[C@H](O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15271526ML00004586CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15281527ML00002483C/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)C3(CCCC3)C2)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00002483_numbered.png2026-03-19 06:55:07.585329
15291528ML00006876C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](OC(=O)CCCC(=O)O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00006876_numbered.png2026-03-19 06:55:07.612337
15301529ML00006894C=C(C)[C@@H](C)[C@@H]1/C=C\C(=O)C[C@@H]2O[C@H]2[C@@H]2CC(=C)[C@@H](C)[C@](O)(CC(=O)O1)O2non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15311530ML00005003CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15321531ML00010425COc1ccc(C[C@@H]2NC(=O)[C@@]34OC(=O)O/C=C\[C@@](C)(O)C(=O)[C@H](C)C/C=C\[C@H]3[C@@H]3O[C@]3(C)[C@@H](C)[C@@H]24)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15331532ML00007372CCCCC[C@@H]1CC[C@H](C)CCCCC(=O)N(C)[C@@H](Cc2ccc(OCCO)cc2)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15341533ML00005767CO[C@@H]1[C@H](O[C@@H]2[C@H](OC)CO[C@@H](O[C@@H]3C[C@@H]4CC(=O)[C@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)[C@@H]2OC)O[C@@H](C)[C@@H](OC)[C@@H]1OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15351534ML00001233CHEMBL1778156CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15361535ML00008299C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](SCC(N)C(=O)O)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00008299_numbered.png2026-03-19 06:55:07.689344
15371536ML00003185C/C=C1\NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC)[C@@H](C)OC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15381537ML00007077CCCCC[C@]1(C)/C=C\C2[C@H](O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O1standard_macrolactone13.0success2.0[3, 3]ring_size_13/standard/numbered/ML00007077_numbered.png2026-03-19 06:55:07.723616
15391538ML00001894CHEMBL1082035COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)/C=C\[C@@H](CC(F)(F)F)[C@H](C)OC2=Ostandard_macrolactone13.0success4.0[3, 4, 7, 8]ring_size_13/standard/numbered/ML00001894_numbered.png2026-03-19 06:55:07.772743
15401539ML00005337CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15411540ML00008291C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])CCCO)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00008291_numbered.png2026-03-19 06:55:07.813824
15421541ML00006936C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](SCCCCO)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00006936_numbered.png2026-03-19 06:55:07.844024
15431542ML00009926CCCCCC[C@H](C)[C@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H](CC(C)C)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15441543ML00010044C/C=C1\NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)N[C@@H](C)C(C)=O)[C@@H](C)OC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15451544ML00010678CC(C)(C)[C@H]1COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15461545ML00003701CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)C(C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([N+](C)(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15471546ML00000709CHEMBL262052CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15481547ML00007007CC(=O)C[C@H](O)CC(=O)[C@H]1OC(=O)CCCCCCCCc2ccccc21standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00007007_numbered.png2026-03-19 06:55:07.905943
15491548ML00003830CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15501549ML00005350CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15511550ML00008546CC1=CC(=O)OC2CCN3CCC(COC(=O)C(C)(O)C(C)C1)C23non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15521551ML00003236C/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3C2CCC(=O)C32CCCC2)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00003236_numbered.png2026-03-19 06:55:07.968769
15531552ML00002275CC[C@H]1OC(=O)[C@H](C)[C@@H](OCc2cn(CC(=O)O)nn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15541553ML00001803CHEMBL3355001O=C1OCCOc2cc(F)ccc2Nc2ncnc3[nH]c4c(c23)CC1CC4non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15551554ML00010288CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](C[C@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15561555ML00009324COc1cc(/C=C2/C(=O)OC[C@H]3O[C@H](O[C@]4(CO)O[C@H](CO)[C@@H](O)[C@@H]4OC(=O)/C2=C/c2cc(OC)c(O)c(OC)c2)[C@H](O)[C@@H](O)[C@H]3O)cc(OC)c1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15571556ML00008173O=C1OC[C@@]2(O)CO[C@@H](O[C@H]3[C@@H](OC[C@@H](O)[C@@H]3O)Oc3ccc(O)c1c3)[C@@H]2Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15581557ML00006658O=C1CCC/C=C\C[C@H]2C(=O)C[C@@H](O)C2/C=C\[C@@H](CCc2ccccc2)O1standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00006658_numbered.png2026-03-19 06:55:08.029354
15591558ML00005390CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15601559ML00000619CHEMBL2371731CCCCC(C)C1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15611560ML00006542CC[C@H]1OC(=O)[C@H](C)[C@@H](OCc2cn(Cc3ccccc3)nn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15621561ML00008930O=C1OC[C@H](c2ccccc2)NC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C/CC[C@H]1Cc1ccc(F)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15631562ML00005290CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15641563ML00001989CHEMBL1933480CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C2=N[C@H](CO2)C(=O)N[C@H](C2CCCCC2)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15651564ML00003904C#CCO[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@](C)(OC(=O)C(C)C)[C@@H](CC)OC(=O)[C@@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15661565ML00007301CC1=C[C@H]2/C=C\C[C@@H](C)C(=O)[C@H](C)/C=C\OC(=O)O[C@@]23C(=O)N[C@H](Cc2ccccc2)[C@H]3[C@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15671566ML00000826CHEMBL338024CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)N[C@H]1COC(=O)CCC(CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15681567ML00006954COC(=O)CC[S+]([O-])[C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1Ostandard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00006954_numbered.png2026-03-19 06:55:08.129675
15691568ML00004084C/C=C1\CC(c2cc(CO)cc(CC(O)C(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00004084_numbered.png2026-03-19 06:55:08.161972
15701569ML00010367COc1ccc(C[C@H]2NC(=O)[C@]34OC(=O)O/C=C\[C@](C)(O)C(=O)[C@H](C)C/C=C\[C@@H]3[C@@H](O)[C@@](C)(O)[C@H](C)[C@H]24)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15711570ML00007045CCCCC[C@H]1/C=C\[C@H]2[C@H](OC(C)=O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O1standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00007045_numbered.png2026-03-19 06:55:08.192042
15721571ML00008621C/C1=C/C(=O)O[C@@H]2CC[N+]3([O-])CC=C(COC(=O)[C@](C)(O)[C@H](C)C1)[C@H]23non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15731572ML00005006CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15741573ML00007289CC1=C(C)[C@H]2[C@H](Cc3ccccc3)NC(=O)[C@]23OC(=O)O/C=C/[C@@](C)(O)C(=O)[C@@H](C)C/C=C/[C@H]3[C@@H]1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15751574ML00007121O=C1CCC/C=C\C[C@@H]2C(/C=C\[C@@H](COc3ccccc3)O1)[C@H](O)C[C@@H]2Ostandard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00007121_numbered.png2026-03-19 06:55:08.239988
15761575ML00010424O=C1NCCOC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15771576ML00007009CC/C=C\C[C@H]1/C=C\[C@H]2[C@H](OC(C)=O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O1standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00007009_numbered.png2026-03-19 06:55:08.270311
15781577ML00010667CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15791578ML00007283CC1=C(C)[C@@H]2[C@H](Cc3ccccc3)NC(=O)[C@]23OC(=O)O/C=C\[C@@](C)(O)C(=O)[C@@H](C)C/C=C\[C@H]3[C@H]1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15801579ML00005753CO[C@@H]1[C@H](O[C@H]2[C@H](OC)CO[C@@H](O[C@H]3C[C@H]4CC(=O)[C@@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C=C/C5CCCCC5)OC(=O)C[C@H](O4)[C@@H]3C)[C@@H]2OC)O[C@@H](C)[C@@H](O)[C@@H]1OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15811580ML00010928CCCCCC[C@H](C)[C@H]1CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15821581ML00005458CC[C@H](C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC)[C@@H](C)CC)[C@H](C)CC)[C@@H](C)CC)[C@H](C)OC(=O)[C@H]([C@@H](C)CC)NC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15831582ML00010484O=C1OC[C@H]2CCCN2C(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\CC[C@@H]1Cc1ccc(F)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15841583ML00006773O=C1CCC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@H]2CO1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15851584ML00009942CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C[C@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15861585ML00010925CCCCC[C@@H](CC(=O)N1N=CCC[C@@H]1C(=O)N[C@H]1COC(=O)[C@H]2CCCNN2C(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)NC1=O)C(=O)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15871586ML00007123CC(=O)C[C@H](O)CC(=O)[C@H]1OC(=O)CCCCC/C=C/Cc2ccccc21standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00007123_numbered.png2026-03-19 06:55:08.360010
15881587ML00009936CCCCCC[C@H](C)[C@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15891588ML00007823O=C1OCCOc2ncc(F)cc2[C@H]2CCCN2c2ccn3ncc1c3n2non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15901589ML00002833C/C=C1\CC(c2cc(CO)c(CCCCC)c(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00002833_numbered.png2026-03-19 06:55:08.404989
15911590ML00003339CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([N+](C)(C)C)C2O)[C@]2(C)C[C@@H](C)C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15921591ML00010173C[C@H]1COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15931592ML00004914CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N2C[C@@H](N)C[C@H]2C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15941593ML00006655C/C=C1\NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccccc2)[C@@H](C)OC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15951594ML00010506O=C(C[C@@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)OC[C@@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15961595ML00000134CHEMBL27424CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
15971596ML00002496C/C=C1\CC(c2ccc(CCCCC)c(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00002496_numbered.png2026-03-19 06:55:08.482421
15981597ML00008805C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](SCC(=O)O)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00008805_numbered.png2026-03-19 06:55:08.512973
15991598ML00007307O=C(C[C@H]1C/C=C/CC[C@@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)NCCOnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16001599ML00008748O=C(C[C@@H]1C/C=C\CCCC(=O)OC[C@@H]2CCCN2C1=O)NCCOnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16011600ML00007296O=C1CCC/C=C/C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16021601ML00009255CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](C[C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16031602ML00005198CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(C)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16041603ML00003726CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H]([C@H](C)O)[C@@](C)(O)[C@H](O)[C@@H](C)C3=C(C)C[C@@]2(C)O3)[C@@H]1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16051604ML00009374CCCCCC[C@H](C)[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]([C@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16061605ML00001369CHEMBL65918CC(C)(C)S(=O)(=O)C[C@@H](Cc1ccccc1)C(=O)NC1CSCCC[C@H](CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16071606ML00001367CHEMBL264636CC(C)(C)CC1CCC(=O)OC[C@H](NC(=O)C(Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC2CCCCC2)[C@@H](O)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16081607ML00002096CHEMBL431854CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCC(=O)NCCOC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16091608ML00004182CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C(C)C)[C@H]3O)[C@@]3(C)CC(C)=C(O3)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H]([C@H](C)O)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16101609ML00008459CCCCC[C@@H]1/C=C\C2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O1standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00008459_numbered.png2026-03-19 06:55:08.613921
16111610ML00009937CCCC[C@H](C)[C@H]1CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16121611ML00002030CHEMBL1597050C[C@H]1C/C=C/[C@@H]2[C@@H]3O[C@]3(C)[C@@H](C)[C@H]3[C@H](Cc4ccccc4)NC(=O)[C@]32OC(=O)O/C=C/[C@](C)(O)C1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16131612ML00000139CHEMBL265495CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16141613ML00008755CO[C@H]1C[C@H]2/C=C\CCC[C@H](C)OC(=O)/C=C/[C@@H](OC)[C@@H]2C1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008755_numbered.png2026-03-19 06:55:08.660325
16151614ML00009509CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16161615ML00008252C[C@@H]1CCC/C=C\[C@H]2CC(=O)C[C@@H]2[C@@H](O)/C=C\C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008252_numbered.png2026-03-19 06:55:08.694027
16171616ML00006692C[C@@H]1COC(=O)CCC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16181617ML00007203CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16191618ML00008086C[C@H]1C[C@@H](CO)/C=C\C(=O)O[C@H](C)C/C=C\C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16201619ML00009257CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CC(C)C)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16211620ML00008548C/C1=C/C(=O)O[C@@H]2CCN3CC[C@H](COC(=O)[C@](C)(O)[C@H](C)C1)[C@@H]23non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16221621ML00004987CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16231622ML00008297COC(=O)CS(=O)(=O)[C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1Ostandard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00008297_numbered.png2026-03-19 06:55:08.767586
16241623ML00008145C[C@@H]1CCC/C=C\[C@H]2C[C@@H](O)C[C@@H]2[C@@H](O)/C=C\C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008145_numbered.png2026-03-19 06:55:08.796505
16251624ML00002387CO[C@@H]1[C@@H](OC)[C@H](O[C@H]2[C@H](OC)[C@H](O[C@@H]3C[C@@H]4CC(=O)[C@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)OC[C@H]2O)O[C@H](C)[C@H]1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16261625ML00008185C[C@H]1CCC/C=C/C2C[C@H](O)CC2[C@H](O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008185_numbered.png2026-03-19 06:55:08.831829
16271626ML00007200CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16281627ML00008224C[C@H]1CCC/C=C\[C@H]2CCC[C@H]2[C@H](O)/C=C\C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008224_numbered.png2026-03-19 06:55:08.865884
16291628ML00002257C/C=C1\NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(C)=O)[C@@H](C)OC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16301629ML00000705CHEMBL297168CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16311630ML00000367CHEMBL1714012O=C(C[C@@H]1C/C=C/CC[C@@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)NCCOnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16321631ML00009834CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16331632ML00008921O=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)N[C@@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16341633ML00006721C[C@@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16351634ML00006941C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])CCCCO)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00006941_numbered.png2026-03-19 06:55:08.940979
16361635ML00007286C[C@H]1C/C=C\[C@H]2[C@@H]3O[C@]3(C)[C@@H](C)[C@H]3[C@H](Cc4ccccc4)NC(=O)[C@@]23OC(=O)O/C=C\[C@@](C)(O)C1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16371636ML00010821O=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](Cc2c[nH]c3ccccc23)NC1=O)NCCOnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16381637ML00003707CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)C(C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16391638ML00010094CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16401639ML00001083CHEMBL1669774CC(=O)Oc1cc2c(c(OC(C)=O)c1)C(=O)OCCCCCCCCC2standard_macrolactone13.0success0.0[]ring_size_13/standard/numbered/ML00001083_numbered.png2026-03-19 06:55:08.988243
16411640ML00005453CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16421641ML00008452CCCCC[C@@H]1/C=C\C2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O1standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00008452_numbered.png2026-03-19 06:55:09.020284
16431642ML00000137CHEMBL1628277CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16441643ML00000704CHEMBL289955CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16451644ML00006946C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](SCCN(C)C)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00006946_numbered.png2026-03-19 06:55:09.066147
16461645ML00005424CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16471646ML00010287CCCCC(C)C1CC(=O)NC(Cc2ccccc2)C(=O)NC(C)C(=O)NC(C(C)(C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16481647ML00010807O=C1CCC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)CO1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16491648ML00007070COC(=O)CCCC(=O)O[C@@H]1/C=C/C(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]21standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00007070_numbered.png2026-03-19 06:55:09.116100
16501649ML00002388CO[C@@H]1[C@@H](O[C@H]2C[C@H]3CC(=O)[C@]4(O)O[C@@H](C[C@@H]4C)C(C)(C)[C@H](/C=C/C=C/C=C/C(C)C)OC(=O)C[C@H](O3)[C@@H]2C)OC[C@H](O)[C@H]1O[C@H]1O[C@@H](C)[C@H](O)[C@@H](OC)[C@@H]1OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16511650ML00007073O=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)OCCNC1=O)NCCOnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16521651ML00007290CC1=C(C)[C@H]2[C@H](Cc3ccccc3)NC(=O)[C@]23OC(=O)O/C=C\[C@@](C)(O)C(=O)[C@@H](C)C/C=C\[C@H]3[C@@H]1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16531652ML00008659C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3C[C@H](OC1=O)[C@H](O)[C@H]23non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16541653ML00006638CO[C@H]1C(=O)OC[C@H](O)c2ccc3c(c2Cl)[C@@]24O[C@]5(O)C(=C(C)C(=O)[C@]16O[C@@H]56)O[C@@]2([C@H](O)C[C@H]4O)[C@@H]3Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16551654ML00005283CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(N)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16561655ML00005208CC[C@H](C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC)[C@@H](C)CC)[C@H](C)CC)[C@@H](C)CC)[C@H](C)OC(=O)[C@H]([C@@H](C)CC)NC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16571656ML00007004C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])c2ccc(O)cc2)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00007004_numbered.png2026-03-19 06:55:09.201791
16581657ML00002652CO[C@H]1[C@H](C)O[C@H](O[C@@H]2[C@@H](O)CO[C@H](O[C@H]3C[C@H]4CC(=O)[C@]5(O)O[C@@H](C[C@@H]5C)C(C)(C)[C@H](/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)[C@H]2OC)[C@@H](OC)[C@@H]1OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16591658ML00007565O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OO[C@@H]([C@@H]2O)[C@H]1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16601659ML00009833CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16611660ML00008932O=C1N[C@@H](c2ccccc2)COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16621661ML00010307CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](C[C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16631662ML00000812CHEMBL339673CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)N[C@H]1CCC(=O)OCC(CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16641663ML00005017CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16651664ML00009724O=C1OC[C@H](Cc2ccccc2)NC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C/CC[C@H]1Cc1ccc(F)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16661665ML00006765O=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)NCCOnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16671666ML00005000CCCc1ccc(-c2ccc(C[C@@H](N)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]3C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]3C)[C@@H](C)CC)[C@H](C)CC)[C@@H](C)CC)cc2)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16681667ML00006828COc1ccc(CS[C@@H]2CC(=O)O[C@@H](C)CCC/C=C/[C@@H]3C[C@H](O)C[C@H]3[C@@H]2O)cc1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00006828_numbered.png2026-03-19 06:55:09.309492
16691668ML00003867C=CC[N+](C)(C)C1CC(C)OC(O[C@@H]2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)[C@@](C)(O)[C@H](O)[C@@H](C)C3O[C@@]2(C)C[C@H]3C)C1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16701669ML00002174COC1C(O)C(C)OC(O[C@H]2C(OC)COC(O[C@H]3C[C@H]4CC(=O)[C@@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/c5ccccc5)OC(=O)C[C@H](O4)[C@@H]3C)[C@@H]2OC)[C@H]1OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16711670ML00010930CCCCCCC(C)C1CC(=O)NC(C(C)C)C(=O)NC(Cc2ccccc2)C(=O)NC(C(C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16721671ML00008929O=C1N[C@@H](c2ccccc2)COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16731672ML00002634CO[C@@H]1[C@H](O[C@H]2[C@H](OC)CO[C@@H](O[C@H]3C[C@H]4CC(=O)[C@@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)[C@@H]2OC)O[C@@H](C)[C@@H](O)[C@@H]1OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16741673ML00010503O=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16751674ML00002052CHEMBL1438113CC(C)(C)[C@H]1COC(=O)CCC/C=C/C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16761675ML00009935CCCCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16771676ML00007306O=C(C[C@H]1C/C=C/CC[C@H](Cc2ccc(F)cc2)C(=O)O[C@H](c2ccccc2)CNC1=O)NCCOnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16781677ML00005192CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16791678ML00005768CO[C@H]1[C@@H](OC)[C@H](OC)[C@@H](C)O[C@@H]1O[C@H]1[C@H](OC)[C@H](O[C@H]2C[C@H]3CC(=O)[C@]4(O)O[C@@H](C[C@@H]4C)C(C)(C)[C@H](/C=C/C=C/C=C/C(C)C)OC(=O)C[C@H](O3)[C@@H]2C)OC[C@H]1OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16801679ML00002488CC(C)CC/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00002488_numbered.png2026-03-19 06:55:09.420245
16811680ML00009729O=C1N[C@@H](Cc2ccccc2)COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16821681ML00003364CCNCC/C=C1\CC(c2cccc(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00003364_numbered.png2026-03-19 06:55:09.459514
16831682ML00010500O=C1OC[C@@H]2CCCN2C(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\CC[C@H]1Cc1ccc(F)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16841683ML00009516CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16851684ML00006076CC[C@H]1OC(=O)[C@H](C)[C@@H](OCc2cn(-c3cnc4ccccc4c3)nn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16861685ML00000016CHEMBL19980BREFELDIN AC[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00000016_numbered.png2026-03-19 06:55:09.507527
16871686ML00010929CCCCCC[C@H](C)[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H]([C@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16881687ML00008517COC(=O)[C@@]1(O)/C=C\C[C@H](C)OC(=O)c2c(O)cc(OC)cc2[C@H]2O[C@@H]2C[C@@H]1Ostandard_macrolactone13.0success4.0[3, 7, 7, 8]ring_size_13/standard/numbered/ML00008517_numbered.png2026-03-19 06:55:09.546808
16891688ML00008301C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])CC(N)C(=O)O)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00008301_numbered.png2026-03-19 06:55:09.578619
16901689ML00007116C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](Sc2ccc(Br)cc2)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00007116_numbered.png2026-03-19 06:55:09.609654
16911690ML00003352CC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC(C3(O)CCCC4CC(=O)CCC43)OC(=O)/C(=C/CO)C2)c1standard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00003352_numbered.png2026-03-19 06:55:09.642120
16921691ML00005454CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16931692ML00006966CCCCC[C@@H]1/C=C\C2[C@H](O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O1standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00006966_numbered.png2026-03-19 06:55:09.675579
16941693ML00007014C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](Sc2ccc(N)cc2)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00007014_numbered.png2026-03-19 06:55:09.705703
16951694ML00008142C[C@H]1CCC[C@@H]2O[C@@H]2[C@@H]2C[C@H](O)C[C@H]2[C@H](O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008142_numbered.png2026-03-19 06:55:09.731082
16961695ML00003820C=CC[N+](C)(C)[C@@H]1C[C@@H](C)O[C@@H](O[C@@H]2C(C)C(O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@@H](C)O3)C(C)C(=O)OC(CC)[C@@](C)(O)[C@H](O)[C@@H](C)C3=C(C)C[C@]2(C)O3)[C@@H]1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16971696ML00008043CCC[C@H]1CCCCCCCC(=O)OCCN1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16981697ML00007298CC1CC=CC2C3OC3(C)C(C)C3C(Cc4ccccc4)NC(=O)C23OC(=O)OC=CC(C)(O)C1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
16991698ML00010275CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CC(C)C)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17001699ML00010268CCCCCCCCCCC(C)C1OC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(C(C)C)NC(=O)C1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17011700ML00006762O=C(C[C@@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)OC[C@@H]2CCCN2C1=O)NCCOnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17021701ML00008400CC(=O)O[C@H]1C[C@H]2/C=C\CCC[C@H](C)OC(=O)/C=C/[C@@H](OC(C)=O)[C@@H]2C1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008400_numbered.png2026-03-19 06:55:09.796479
17031702ML00001502CHEMBL4068515CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17041703ML00006701COc1ccc([S+]([O-])[C@@H]2CC(=O)O[C@@H](C)CCC/C=C/[C@@H]3C[C@H](O)C[C@H]3[C@@H]2O)cc1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00006701_numbered.png2026-03-19 06:55:09.837657
17051704ML00005207CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CN)C(=O)N[C@H]1C(=O)N[C@@H](CN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17061705ML00011005CCCCC[C@@H](CC(=O)N1N=CCC[C@@H]1C(=O)N[C@H]1COC(=O)[C@H]2CCC=NN2C(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)NC1=O)C(=O)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17071706ML00010502O=C(C[C@@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17081707ML00003069CC[C@H]1OC(=O)[C@H](C)[C@@H](OCc2cn(CCO)nn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17091708ML00008226CC1CCC/C=C/C2CCCC2C(O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008226_numbered.png2026-03-19 06:55:09.894818
17101709ML00010421O=C1NCCOC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17111710ML00009514CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17121711ML00002707CO[C@H]1[C@@H](O)[C@@H](C)O[C@H](O[C@H]2[C@H](OC)CO[C@@H](O[C@H]3C[C@H]4CC(=O)[C@]5(O)O[C@@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)[C@@H]2OC)[C@@H]1OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17131712ML00007196CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17141713ML00010137CC[C@H]1OC(=O)[C@H](C)[C@@]2(O)O[C@@](C)(C[C@@H](C)/C(=N\O)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17151714ML00007069COC(=O)CCCC(=O)O[C@H]1C[C@H]2/C=C/CCC[C@H](C)OC(=O)/C=C/[C@@H](O)[C@@H]2C1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00007069_numbered.png2026-03-19 06:55:09.955685
17161715ML00005001CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17171716ML00007195CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17181717ML00003831CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17191718ML00003600O=C1N[C@@H](Cc2c[nH]c3ccccc23)COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17201719ML00009193CCCCCCCC[C@H](C)[C@H]1OC(=O)[C@@H](CO)NC(=O)[C@@H](C(=O)c2c[nH]c3ccccc23)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17211720ML00009927CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C[C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17221721ML00005033CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(-c2ccc(-c3ccccc3)cc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17231722ML00008076O=C1C/C=C\C/C=C\CCCCCO1standard_macrolactone13.0success0.0[]ring_size_13/standard/numbered/ML00008076_numbered.png2026-03-19 06:55:10.029306
17241723ML00007601O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCC[C@H](CCc2cccc3ccccc23)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00007601_numbered.png2026-03-19 06:55:10.056122
17251724ML00010927CC(C)C[C@H]1NC(=O)[C@@H](NC(=O)[C@@H]2CCC=NN2C(=O)C[C@@H](CCC[C@H](C)O)C(=O)O)COC(=O)[C@H]2CCCNN2C(=O)[C@H](C)NC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17261725ML00007122CC(=O)C[C@@H](O)CC(=O)[C@@H]1OC(=O)CCCCC/C=C/Cc2ccccc21standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00007122_numbered.png2026-03-19 06:55:10.087003
17271726ML00010419O=C(C[C@@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](Cc2ccccc2)NC1=O)NCCOnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17281727ML00003730CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17291728ML00003727CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CCO)[C@@](C)(O)[C@H](O)[C@@H](C)C3=C(C)C[C@@]2(C)O3)[C@@H]1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17301729ML00008996CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17311730ML00000645CHEMBL1572153C[C@H]1CCC/C=C/C2C[C@H](O)C[C@H]2[C@H](O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00000645_numbered.png2026-03-19 06:55:10.142315
17321731ML00004509CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CN)C(=O)N[C@H](CN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17331732ML00009492C/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00009492_numbered.png2026-03-19 06:55:10.187613
17341733ML00007036C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])c2cccc(N)c2)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00007036_numbered.png2026-03-19 06:55:10.221805
17351734ML00000157CHEMBL2373603C[C@H]1CCC/C=C/[C@@H]2C[C@@H](O)C[C@]2(O)C/C=C\C(=O)O1standard_macrolactone13.0success2.0[3, 10]ring_size_13/standard/numbered/ML00000157_numbered.png2026-03-19 06:55:10.249506
17361735ML00007010C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](Sc2ccc(O)cc2)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00007010_numbered.png2026-03-19 06:55:10.282246
17371736ML00000710CHEMBL43313CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17381737ML00008915CCCCCCCCCCCCC[C@H](O)[C@H](C)[C@H]1OC(=O)[C@@H](COC(C)=O)NC(=O)[C@@H]([C@H](C)OS(=O)(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17391738ML00004269CC(C)CCCCCCCCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H]1COC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)[C@@H](C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17401739ML00008931O=C1N[C@@H](c2ccccc2)COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17411740ML00008860CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C[C@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17421741ML00006631O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCC[C@H](CCc2ccc(C(F)(F)F)cc2)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00006631_numbered.png2026-03-19 06:55:10.352082
17431742ML00006978O=C(C[C@@H]1C/C=C\CCCC(=O)OC[C@@H](c2ccccc2)NC1=O)NCCOnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17441743ML00008295COC(=O)CS[C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1Ostandard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00008295_numbered.png2026-03-19 06:55:10.392766
17451744ML00006769COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)/C=C\[C@@H](Cc1ccccc1)[C@H](C)OC2=Ostandard_macrolactone13.0success4.0[3, 4, 7, 8]ring_size_13/standard/numbered/ML00006769_numbered.png2026-03-19 06:55:10.430079
17461745ML00003870C#CC[N+](C)(C)[C@@H]1C[C@@H](C)O[C@@H](O[C@@H]2C(C)C(O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@@H](C)O3)C(C)C(=O)OC(CC)[C@@](C)(O)[C@H](O)[C@@H](C)C3=C(C)C[C@]2(C)O3)[C@@H]1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17471746ML00003602C/C=C1\CC(c2cc(CO)cc(NCC)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00003602_numbered.png2026-03-19 06:55:10.474610
17481747ML00008296COC(=O)C[S+]([O-])[C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1Ostandard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00008296_numbered.png2026-03-19 06:55:10.508169
17491748ML00006897C[C@@H]1[C@@H](O)C[C@H]2CC(=O)[C@@]3(O)O[C@H](C[C@H]3C)C(C)(C)[C@@H](/C=C/I)OC(=O)C[C@@H]1O2non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17501749ML00003338CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([N+](C)(C)C)C2O)[C@]2(C)C[C@@H](C)C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17511750ML00009723O=C1N[C@H](Cc2ccccc2)COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17521751ML00004510CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CN)C(=O)N[C@H]1C(=O)N[C@@H](CN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17531752ML00010677CC(C)(C)[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17541753ML00001896CHEMBL1076352O=C(C[C@@H]1C/C=C/CCCC(=O)OCCNC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17551754ML00008144C[C@H]1CCCC=CC2C[C@H](O)CC2[C@H](O)C=CC(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008144_numbered.png2026-03-19 06:55:10.584152
17561755ML00005425CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17571756ML00006817C[C@H]1CCC/C=C/[C@@H]2C[C@H](OC(=O)CCC(=O)O)C[C@H]2[C@H](OC(=O)CCC(=O)O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00006817_numbered.png2026-03-19 06:55:10.623939
17581757ML00000474CHEMBL1355410CCC1OC(=O)C(C)C(=O)C(C)[C@@H](OC2OC(C)CC(N(C)C)C2O)C(C)(OC)C2(CCCn3cnc(-c4cccnc4)c3)CC(C)C(=O)C(C)C3N(C2)C(=O)O[C@]13Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17591758ML00007809C[C@H]1C/C=C\Cc2ccc(o2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17601759ML00007082O=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)OCCNC1=O)NCCOnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17611760ML00006683CCOP(=O)(CC[Se][C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1O)OCCstandard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00006683_numbered.png2026-03-19 06:55:10.675902
17621761ML00009569CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)N=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17631762ML00010664CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H](CC(C)C)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17641763ML00005196CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17651764ML00008114O=C1CCCCCCCCCCCO1standard_macrolactone13.0success0.0[]ring_size_13/standard/numbered/ML00008114_numbered.png2026-03-19 06:55:10.720962
17661765ML00010090CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc2ccccc2)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17671766ML00007292C=C1[C@@H](C)[C@H]2[C@H](Cc3ccccc3)NC(=O)[C@]23OC(=O)O/C=C\[C@@](C)(O)C(=O)[C@@H](C)C/C=C\[C@H]3[C@@H]1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17681767ML00002653CO[C@@H]1[C@H](O[C@@H]2C[C@@H]3CC(=O)[C@]4(O)O[C@H](C[C@H]4C)C(C)(C)[C@@H](/C=C/C=C/C(C)C)OC(=O)C[C@H](O3)[C@@H]2C)OC[C@@H](O)[C@H]1O[C@@H]1O[C@H](C)[C@@H](OC)[C@H](OC)[C@H]1OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17691768ML00005002CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17701769ML00007006CC(=O)C[C@@H](O)CC(=O)[C@H]1OC(=O)CCCCCCCCc2ccccc21standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00007006_numbered.png2026-03-19 06:55:10.775116
17711770ML00009857CCCCCCCCO[C@H]1O[C@@H]2COC(=O)CC/C=C/CCC(=O)O[C@H]2[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17721771ML00008524COc1cc(O)c2c(c1C)C(=O)O[C@H](CO)CC/C(S)=N/[C@H](c1nc(C)no1)CSC2non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17731772ML00008186CC1CCCC=CC2CC(O)CC2C(O)C=CC(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008186_numbered.png2026-03-19 06:55:10.813167
17741773ML00008158COc1cc(O)cc2c1C(=O)OO[C@@H](C)CCCCC/C=C\2non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17751774ML00008080O=C1CCCCCCCC(=O)OCCO1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17761775ML00000092CHEMBL1701527O=C(C[C@@H]1C/C=C/CC[C@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](Cc2ccccc2)NC1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17771776ML00001444CHEMBL1933481CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](Cn2cc(CNC(=O)CCCCNC(=O)CCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)C(=O)N[C@H](C2CCCCC2)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17781777ML00007714C[C@@H]1CC(O)C2C=CC(CC(=O)Cc3c(Cl)c(O)cc(O)c3C(=O)O1)O2non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17791778ML00008787CCCCC[C@@H]1CCCCC[C@@H]2CC(=O)[C@H](CCC(=O)O1)O2non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17801779ML00008673COc1cc(O)c(Cl)c2c1C(=O)O[C@@H](C)CC[C@H]1CC[C@@H](CC(=O)C2)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17811780ML00000382CHEMBL1736166O=C(C[C@@H]1C/C=C/CC[C@@H](Cc2ccc(F)cc2)C(=O)O[C@H](c2ccccc2)CNC1=O)NCCOnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17821781ML00001749CHEMBL1080649O=C(C[C@@H]1C/C=C/CCCC(=O)O[C@@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17831782ML00010675CC(C)(C)[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17841783ML00010308CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](C[C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17851784ML00000067CHEMBL2373625C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@@H]2[C@H](O)/C=C\C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00000067_numbered.png2026-03-19 06:55:10.909000
17861785ML00010368COc1ccc(C[C@@H]2NC(=O)[C@@]34OC(=O)O/C=C/[C@@](C)(O)C(=O)[C@@H](C)C/C=C/[C@H]3[C@H](O)[C@](C)(O)[C@@H](C)[C@@H]24)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17871786ML00007841COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OCCC/C(S)=N/1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17881787ML00007049C[C@H]1CCC/C=C/[C@@H]2C[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)C[C@H]2[C@H](O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00007049_numbered.png2026-03-19 06:55:10.953277
17891788ML00010418O=C(C[C@@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](Cc2ccccc2)NC1=O)NCCOnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17901789ML00006862CCCCCCCCO[C@H]1O[C@@H]2COC(=O)CC[C@H]3O[C@@H]3CCC(=O)O[C@H]2[C@H](O)[C@H]1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17911790ML00008441C[C@H]1CCC/C=C/[C@@H]2C[C@H](OC(=O)CN(C)C)C[C@H]2[C@H](O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008441_numbered.png2026-03-19 06:55:10.994395
17921791ML00006877C[C@H]1CCC/C=C/[C@@H]2C[C@H](OC(=O)CCCC(=O)O)C[C@H]2[C@H](O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00006877_numbered.png2026-03-19 06:55:11.020232
17931792ML00008453CCCCC[C@H]1/C=C\[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O1standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00008453_numbered.png2026-03-19 06:55:11.042530
17941793ML00005439CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCN=C(N(C)C)N(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17951794ML00000713CHEMBL166642CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17961795ML00008949CCCCCCCCCCCCC[C@H](O)[C@H](C)[C@H]1OC(=O)[C@H](COC(C)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17971796ML00006706C[C@H]1COC(=O)CCC/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
17981797ML00001790CHEMBL1077390COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)/C=C\[C@@H](C)COC2=Ostandard_macrolactone13.0success3.0[4, 7, 8]ring_size_13/standard/numbered/ML00001790_numbered.png2026-03-19 06:55:11.102184
17991798ML00007308O=C(C[C@@H]1C/C=C/CC[C@H](Cc2ccc(F)cc2)C(=O)O[C@H](c2ccccc2)CNC1=O)NCCOnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18001799ML00005456CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC)[C@@H](C)CC)[C@H](C)CC)[C@@H](C)CC)[C@H](C)OC(=O)[C@H]([C@@H](C)CC)NC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18011800ML00001137CHEMBL1368499O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18021801ML00004060O=C(O)C[C@@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4cc(c(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1[C@H](O)C(=O)O3non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18031802ML00006035CC[C@H](C)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18041803ML00010666CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18051804ML00007564O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OO[C@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18061805ML00007410O=C(OC1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)COC(C2O)C1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18071806ML00004738CC[C@H]1OC(=O)[C@H](C)[C@@H](OCc2cn(C34CC5CC(CC(C5)C3)C4)nn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18081807ML00009731C/C=C1\CC(c2cc(CO)cc(NCC)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00009731_numbered.png2026-03-19 06:55:11.208075
18091808ML00008305C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])C[C@@H](C)O)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00008305_numbered.png2026-03-19 06:55:11.238860
18101809ML00005206CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18111810ML00009735C/C=C1\CC(c2cccc(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00009735_numbered.png2026-03-19 06:55:11.280856
18121811ML00009880C/C=C1\NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(C)=O)[C@@H](C)OC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18131812ML00008052O=C1CCCCCCC/C=C/CCO1standard_macrolactone13.0success0.0[]ring_size_13/standard/numbered/ML00008052_numbered.png2026-03-19 06:55:11.307420
18141813ML00008149CC1CCC/C=C/C2CC(O)CC2C(O)/C=C\C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008149_numbered.png2026-03-19 06:55:11.332065
18151814ML00010670CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18161815ML00009835CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18171816ML00002045CHEMBL1983653O=C1NCCOC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18181817ML00008399CC(=O)O[C@H]1C[C@H]2/C=C/CCC[C@H](C)OC(=O)/C=C/[C@@H](OC(C)=O)[C@@H]2C1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008399_numbered.png2026-03-19 06:55:11.379651
18191818ML00004219CCCCCCCCCCCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H]1COC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)[C@@H](C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18201819ML00008148C[C@H]1CCC/C=C\[C@@H]2C[C@H](O)C[C@H]2[C@H](O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008148_numbered.png2026-03-19 06:55:11.411945
18211820ML00004098C/C=C1\CC(c2cccc(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3C2CCC(=O)C32CCCC2)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00004098_numbered.png2026-03-19 06:55:11.444621
18221821ML00007018C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])c2ccc(N)cc2)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00007018_numbered.png2026-03-19 06:55:11.474800
18231822ML00005205CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18241823ML00010414O=C(C[C@@H]1C/C=C/CC[C@@H](Cc2ccc(F)cc2)C(=O)OCCNC1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18251824ML00007315O=C(C[C@@H]1C/C=C/CCCC(=O)O[C@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18261825ML00007779CC[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00007779_numbered.png2026-03-19 06:55:11.523603
18271826ML00010175C[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18281827ML00009493CC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC(C(C)(O)C3CCC(=O)CC3)OC(=O)/C(=C/CO)C2)c1standard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00009493_numbered.png2026-03-19 06:55:11.562072
18291828ML00003866C=CC[N+](C)(C)C1CC(C)OC(O[C@@H]2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)[C@@](C)(O)[C@H](O)[C@@H](C)C3O[C@@]2(C)C[C@H]3C)C1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18301829ML00008157COc1cc(O)cc2c1C(=O)OOC(C)CCCCC/C=C/2non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18311830ML00008356COc1cc(O)c2c(c1C)C(=O)OCCC/C(S)=N/[C@H](c1nc(C)no1)CSC2non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18321831ML00005452CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18331832ML00008202O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCC[C@H](C(F)(F)F)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008202_numbered.png2026-03-19 06:55:11.618001
18341833ML00009323COc1cc(/C=C2/C(=O)O[C@H]3[C@H](O)[C@@H](CO)O[C@@]3(CO)O[C@H]3O[C@H](COC(=O)/C2=C/c2cc(OC)c(O)c(OC)c2)[C@@H](O)[C@H](O)[C@H]3O)c(OC)cc1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18351834ML00002798CO[C@@H]1[C@H](O[C@H]2[C@H](OC)CO[C@@H](O[C@H]3C[C@H]4CC(=O)[C@@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C#C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)[C@@H]2OC)O[C@@H](C)[C@@H](O)[C@@H]1OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18361835ML00008789CCCCC[C@H]1CCCCC[C@H]2CC(=O)[C@@H](CCC(=O)O1)O2non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18371836ML00002107CHEMBL338764CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)N[C@H]1COC(=O)CCCOC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18381837ML00003347CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CCN)[C@H]2O)[C@@]2(C)C[C@H](C)[C@H](O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18391838ML00008054O=C1C/C=C\CCCCCCCCO1standard_macrolactone13.0success0.0[]ring_size_13/standard/numbered/ML00008054_numbered.png2026-03-19 06:55:11.672121
18401839ML00010669CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18411840ML00003404CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18421841ML00008786CCCCC[C@@H]1CCCCC[C@@H]2CC(=O)[C@H](CCC(=O)O1)O2non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18431842ML00003863CCCCN(C)[C@H]1C[C@@H](C)OC(O[C@@H]2[C@@H](C)[C@H](OC3C[C@@](C)(OC)C[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)[C@H]3O[C@]2(C)C[C@@H]3C)[C@@H]1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18441843ML00008040CC(=O)O[C@@H]1[C@@H]2C(=O)N1C(=O)CC/C=C/CCC(=O)O[C@@H]2Cnon_standard_macrocycle13.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
18451844ML00010499O=C1OC[C@@H]2CCCN2C(=O)[C@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\CC[C@@H]1Cc1ccc(F)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18461845ML00005333CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18471846ML00010997CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](Cc2ccccc2)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18481847ML00008413CCCCC[C@@H]1/C=C\C2C=CC(=O)[C@@H]2C/C=C\CCCC(=O)O1standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00008413_numbered.png2026-03-19 06:55:11.751946
18491848ML00008278C[C@H]1C[C@@]2(C)O[C@H]2C(=O)O[C@H]2CCN(C)C/C=C(/COC(=O)[C@]1(C)O)C2=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18501849ML00009489CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](Cc2ccccc2)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18511850ML00000136CHEMBL27419CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18521851ML00008658C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3C[C@@H](OC1=O)[C@@H](O)[C@@H]23non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18531852ML00001131CHEMBL331085CC(C)CC1CCC(=O)OC[C@H](NC(=O)C(Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC2CCCCC2)[C@@H](O)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18541853ML00003725CC1=C2O[C@](C)(C1)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C(C)C)[C@H]1O)[C@@H](C)[C@H](O[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1)[C@@H](C)C(=O)O[C@H]([C@H](C)O)[C@@](C)(O)[C@H](O)[C@H]2Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18551854ML00006680C/C=C/CNC(=N)NCCCCCCCCN1CCCCOC(=O)CCNC(=N)NC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18561855ML00007008CC(=O)C[C@@H](O)CC(=O)[C@@H]1OC(=O)CCCCCCCCc2ccccc21standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00007008_numbered.png2026-03-19 06:55:11.821620
18571856ML00008754C[C@H]1CCC/C=C\[C@]2(C)C[C@H](O)C[C@@]2(C)[C@H](O)/C=C\C(=O)O1standard_macrolactone13.0success4.0[3, 9, 10, 11]ring_size_13/standard/numbered/ML00008754_numbered.png2026-03-19 06:55:11.852413
18581857ML00008788CCCCC[C@H]1CCCCC[C@H]2CC(=O)[C@@H](CCC(=O)O1)O2non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18591858ML00007371CCC[C@H](O)C[C@@H]1CC[C@H](C)CCCCC(=O)N(C)[C@@H](Cc2ccc(OCCO)cc2)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18601859ML00001936CHEMBL1357349O=C1OC[C@H]2CCCN2C(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\CC[C@H]1Cc1ccc(F)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18611860ML00003275C/C=C1\CC(c2cc(NCC(C)O)cc(C(O)CNC)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00003275_numbered.png2026-03-19 06:55:11.904083
18621861ML00008393C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](SCC(O)CO)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00008393_numbered.png2026-03-19 06:55:11.933556
18631862ML00008451CCCCC[C@@H]1/C=C\C2C(=O)CC(O)[C@@H]2C/C=C\CCCC(=O)O1standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00008451_numbered.png2026-03-19 06:55:11.955708
18641863ML00008454CC/C=C\C/C=C\C[C@@H]1OC(=O)CCC/C=C\C[C@H](O)/C=C\[C@H]1Ostandard_macrolactone13.0success3.0[3, 4, 7]ring_size_13/standard/numbered/ML00008454_numbered.png2026-03-19 06:55:11.984089
18651864ML00006702C[C@H]1COC(=O)[C@@H](N)CC/C=C/C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18661865ML00009725O=C1OC[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C/CC[C@H]1Cc1ccc(F)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18671866ML00006977O=C(C[C@@H]1C/C=C/CCCC(=O)O[C@H](c2ccccc2)CNC1=O)NCCOnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18681867ML00008104C/C1=C/COc2ccc(cc2)/C=C\C(=O)OC1non_standard_macrocycle13.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
18691868ML00003834C#CC[N+](C)(C)[C@@H]1C[C@@H](C)O[C@@H](O[C@@H]2C(C)C(O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@@H](C)O3)C(C)C(=O)OC(CC)[C@@](C)(O)[C@H](O)[C@@H](C)C3=C(C)C[C@]2(C)O3)[C@@H]1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18701869ML00008187C[C@H]1CCCCC[C@@H]2CC(=O)CC2C(=O)CCC(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008187_numbered.png2026-03-19 06:55:12.043139
18711870ML00008228CC1(C)COC(=O)CCCOC(=O)C2CCCCN2C(=O)C1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18721871ML00006722C[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18731872ML00009933CCCCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H](CC(C)C)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18741873ML00007300CC1=C[C@H]2/C=C\C[C@@H](C)C(=O)[C@@](C)(O)/C=C\OC(=O)O[C@]23C(=O)N[C@@H](Cc2ccc(O)cc2)[C@@H]3[C@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18751874ML00010427COc1ccc(C[C@@H]2NC(=O)[C@@]34OC(=O)O/C=C\[C@@](C)(O)C(=O)[C@@H](C)C/C=C\[C@H]3[C@@H]3O[C@]3(C)[C@@H](C)[C@H]24)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18761875ML00001138CHEMBL1733880O=C1NC[C@H](c2ccccc2)OC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18771876ML00003626CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)[C@@H]2O[C@]1(C)[C@@H](N)[C@H]2Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18781877ML00008146C[C@H]1CCC/C=C\[C@@H]2C[C@H](O)C[C@H]2[C@H](O)/C=C\C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008146_numbered.png2026-03-19 06:55:12.114707
18791878ML00008108C[C@@H]1CCCCCCCCCCC(=O)O1standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00008108_numbered.png2026-03-19 06:55:12.137074
18801879ML00007015C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](Sc2cccc(N)c2)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00007015_numbered.png2026-03-19 06:55:12.166581
18811880ML00005210CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18821881ML00007288CC1=C2[C@@H](Cc3ccccc3)NC(=O)[C@@]23OC(=O)O/C=C\[C@@](C)(O)C(=O)[C@@H](C)C/C=C\[C@H]3[C@H](O)[C@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18831882ML00008408CC(=O)O[C@@]1(C)C(=O)OC[C@H]2CCN3CC[C@@H](OC(=O)/C=C(/C)C[C@H]1C)[C@@H]23non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18841883ML00003822C#CC[N+](C)(C)C1CC(C)OC(O[C@@H]2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)[C@@](C)(O)[C@H](O)[C@@H](C)C3O[C@@]2(C)C[C@H]3C)C1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18851884ML00008298COC(=O)CS(=O)(=O)[C@@H]1CC(=O)O[C@@H](C)CCCC2OC2[C@@H]2C[C@H](O)C[C@H]2[C@@H]1Ostandard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00008298_numbered.png2026-03-19 06:55:12.227799
18861885ML00010423O=C1OCCNC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C/CC[C@H]1Cc1ccc(F)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18871886ML00009256CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](C[C@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18881887ML00008141O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCC[C@H](CO)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008141_numbered.png2026-03-19 06:55:12.267894
18891888ML00008249O=C1OCCCCCCCCCc2cc(O)cc(O)c21standard_macrolactone13.0success0.0[]ring_size_13/standard/numbered/ML00008249_numbered.png2026-03-19 06:55:12.287944
18901889ML00010095CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18911890ML00003823C#CC[N+](C)(C)C1CC(C)OC(O[C@@H]2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)[C@@](C)(O)[C@H](O)[C@@H](C)C3O[C@@]2(C)C[C@H]3C)C1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18921891ML00008948CCCCCCCCCCCCC[C@H](O)[C@H](C)[C@H]1OC(=O)[C@@H](COC(C)=O)NC(=O)[C@@H]([C@H](C)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18931892ML00007285C[C@H]1[C@H]2[C@H](Cc3ccccc3)NC(=O)[C@]23OC(=O)O/C=C\[C@@](C)(O)C(=O)[C@H](C)C/C=C\[C@H]3[C@@H]2O[C@]12Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18941893ML00008355COc1cc(O)c2c(c1C)C(=O)OCCCC(=O)N[C@H](c1nc(C)no1)CSC2non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18951894ML00007115C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])c2ccc(Br)cc2)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00007115_numbered.png2026-03-19 06:55:12.350092
18961895ML00005044CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
18971896ML00003599C/C=C1\CC(c2cccc(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCC3CCC4CC(=O)CC3C42)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00003599_numbered.png2026-03-19 06:55:12.393415
18981897ML00009733C/C=C1\CC(c2cc(O)cc(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00009733_numbered.png2026-03-19 06:55:12.425634
18991898ML00002690CO[C@@H]1[C@@H](OC)[C@H](O[C@H]2[C@H](OC)[C@H](O[C@@H]3C[C@@H]4CC(=O)[C@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)OC[C@H]2OC(C)=O)O[C@H](C)[C@H]1OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19001899ML00003801CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19011900ML00006143CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19021901ML00007847COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OCCCC(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19031902ML00008401C[C@H]1CCC/C=C/[C@@H]2C[C@H](OC(=O)CCC(=O)O)C[C@H]2[C@H](O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008401_numbered.png2026-03-19 06:55:12.481250
19041903ML00009923CCCCCCCC[C@@H](C)[C@@H]1OC(=O)[C@H](CO)NC(=O)[C@H](C(=O)c2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19051904ML00002704CO[C@@H]1[C@H](O[C@H]2[C@H](OC(C)=O)CO[C@@H](O[C@H]3C[C@H]4CC(=O)[C@@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)[C@@H]2OC)O[C@@H](C)[C@@H](OC)[C@@H]1OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19061905ML00007423O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCC[C@H](CCc2ccc3cccnc3c2)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00007423_numbered.png2026-03-19 06:55:12.522156
19071906ML00007114C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([Se]c2ccc(Cl)cc2)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00007114_numbered.png2026-03-19 06:55:12.551856
19081907ML00006816O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCC[C@H](CCOCc2ccccc2)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00006816_numbered.png2026-03-19 06:55:12.577967
19091908ML00006950CCCCC[C@@H]1/C=C\C2[C@H](O)C[C@H](O)[C@@H]2CCCCCCC(=O)O1standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00006950_numbered.png2026-03-19 06:55:12.599919
19101909ML00006681C/C=C/CNC(=N)NCCCCCCCCN1CCCCOC(=O)CCNC(=N)NC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19111910ML00008036C/C1=C/C(=O)OC[C@@]2(C)O[C@@H]2CC/C(C)=C\CC1standard_macrolactone13.0success3.0[4, 8, 12]ring_size_13/standard/numbered/ML00008036_numbered.png2026-03-19 06:55:12.633752
19121911ML00003598C/C=C1\CC(c2cccc(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCC3C=CC4CC(=O)CC3C42)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00003598_numbered.png2026-03-19 06:55:12.666699
19131912ML00005016CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19141913ML00005225CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C[C@H]2CNC(=N)N2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19151914ML00008225C[C@H]1CCC/C=C\[C@@H]2CCC[C@H]2[C@H](O)/C=C\C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008225_numbered.png2026-03-19 06:55:12.713737
19161915ML00007109CC(=O)C[C@H](O)CC(=O)[C@@H]1OC(=O)CCCCC/C=C/Cc2ccccc21standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00007109_numbered.png2026-03-19 06:55:12.736454
19171916ML00006637CO[C@H]1C(=O)OC[C@H](O)c2cc(Cl)c3c(c2)[C@@]24O[C@]5(O)C(=C(C)C(=O)[C@]16O[C@@H]56)O[C@@]2([C@H](O)C[C@H]4O)[C@@H]3Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19181917ML00008105C/C1=C/COc2ccc(cc2)/C=C/C(=O)OC1non_standard_macrocycle13.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
19191918ML00005209CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19201919ML00009459CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](NC)[C@H]2O)[C@@]2(C)C[C@H](C)[C@H](O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19211920ML00010277COC(=O)CCCC(=O)O[C@H]1C[C@H]2/C=C/CCC[C@H](C)OC(=O)/C=C/[C@@H](OC(=O)CCCC(=O)OC)[C@@H]2C1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00010277_numbered.png2026-03-19 06:55:12.793742
19221921ML00004503CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](COP(=O)(O)O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)C(C)Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19231922ML00010092CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19241923ML00003677CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19251924ML00003601C/C=C1\CC(c2cccc(CO)c2)C#CC2CC(=O)Oc3c2cc(c(O)c3CC)CC(C2(O)CCCC3CC(=O)CCC32)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00003601_numbered.png2026-03-19 06:55:12.850018
19261925ML00008038CC(=O)O[C@@H]1[C@@H]2C(=O)N1C(=O)CCCCCCC(=O)O[C@@H]2Cnon_standard_macrocycle13.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
19271926ML00009116CC[C@H]1OC(=O)[C@H](C)[C@@]2(O)O[C@@](C)(C[C@@H](C)/C(=N\OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19281927ML00008923O=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)N[C@@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19291928ML00005426CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19301929ML00010174C[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19311930ML00007204CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19321931ML00001833CHEMBL2373671C[C@@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@@H]2[C@H](O)/C=C\C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00001833_numbered.png2026-03-19 06:55:12.918179
19331932ML00005387CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19341933ML00010284CC(C)/C=C/C=C/C=C/[C@H]1OC(=O)C[C@@H]2O[C@H](CC(=O)[C@@]3(O)O[C@H](C[C@H]3C)C1(C)C)C[C@H](O)[C@H]2Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19351934ML00008806COCC[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008806_numbered.png2026-03-19 06:55:12.963949
19361935ML00010289CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](C[C@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19371936ML00008917O=C1NC[C@@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19381937ML00007798C=C[C@@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00007798_numbered.png2026-03-19 06:55:13.002933
19391938ML00010676CC(C)(C)[C@@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19401939ML00008782C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](SCCO)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00008782_numbered.png2026-03-19 06:55:13.040114
19411940ML00006744O=C(/C=C/c1cc(Cl)ccc1-n1cnnn1)N[C@H]1C/C=C/COC(=O)Nc2ccccc2-c2nc1[nH]c2Clnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19421941ML00008239C[C@H]1CCC/C=C\[C@@H]2CC(=O)C[C@H]2[C@H](O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008239_numbered.png2026-03-19 06:55:13.072425
19431942ML00008573C/C1=C/C(=O)O[C@@H]2CC[N+]3([O-])CC[C@H](COC(=O)[C@](C)(O)[C@H](C)C1)[C@H]23non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19441943ML00003276C/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(O)(CCC)C2CCC(=O)CC2)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00003276_numbered.png2026-03-19 06:55:13.110872
19451944ML00005484CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19461945ML00009932CCCCCCCC[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19471946ML00007558CC(C)(C)[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19481947ML00005573CC[C@H]1OC(=O)[C@H](C)[C@@H](OCc2cn(-c3cccnc3)nn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19491948ML00009144C/C=C1\CC(c2cc(O)cc(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00009144_numbered.png2026-03-19 06:55:13.171213
19501949ML00007050C[C@H]1CCC/C=C/[C@@H]2C[C@H](OC3OC(CO)C(O)C(O)C3O)C[C@H]2[C@H](O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00007050_numbered.png2026-03-19 06:55:13.196859
19511950ML00008085C[C@@H]1C/C=C\C(=O)O[C@H](C)C[C@@H](CO)/C=C\C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19521951ML00010135C[C@H]1COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19531952ML00007299CC1=C[C@@H]2/C=C\C[C@H](C)C(=O)[C@@](C)(O)/C=C\OC(=O)O[C@]23C(=O)N[C@@H](Cc2ccc(O)cc2)[C@@H]3[C@@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19541953ML00006698C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([Se]Cc2ccccc2)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00006698_numbered.png2026-03-19 06:55:13.245479
19551954ML00006861COc1ccc(C[S+]([O-])[C@@H]2CC(=O)O[C@@H](C)CCC/C=C/[C@@H]3C[C@H](O)C[C@H]3[C@@H]2O)cc1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00006861_numbered.png2026-03-19 06:55:13.276619
19561955ML00007586O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3cc(c(O)c(O)c3O)C(=O)O[C@@H]([C@@H]2O)[C@H]1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19571956ML00007781O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCC[C@H](CCO)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00007781_numbered.png2026-03-19 06:55:13.313547
19581957ML00005429CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19591958ML00010504O=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)OC[C@@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19601959ML00009545CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)[C@@H](O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19611960ML00008412CC/C=C\C[C@H]1/C=C\[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O1standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00008412_numbered.png2026-03-19 06:55:13.367815
19621961ML00007284C[C@H]1C/C=C/[C@H]2[C@@H]3O[C@]3(C)[C@@H](C)[C@H]3[C@H](Cc4ccccc4)NC(=O)[C@@]23OC(=O)O/C=C/[C@@](C)(O)C1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19631962ML00008752C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](SCCN)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00008752_numbered.png2026-03-19 06:55:13.408728
19641963ML00010926CCCCC[C@@H](CC(=O)N1N=CCC[C@@H]1C(=O)N[C@H]1COC(=O)[C@H]2C[C@@H](O)CNN2C(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)NC1=O)C(=O)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19651964ML00010420O=C(C[C@@H]1C/C=C/CC[C@H](Cc2ccc(F)cc2)C(=O)OCCNC1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19661965ML00009780CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc2ccccc2)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19671966ML00002482C/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3c2cc(c(O)c3CC)CC(C2(O)CCCC3CC(=O)CCC32)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00002482_numbered.png2026-03-19 06:55:13.471470
19681967ML00006540CC[C@H]1OC(=O)[C@H](C)[C@@H](OCc2cn(CC(=O)Nc3ccccn3)nn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19691968ML00004085CC(C)CC/C=C1\CC(c2cccc(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00004085_numbered.png2026-03-19 06:55:13.516187
19701969ML00008919O=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)O[C@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19711970ML00001130CHEMBL279862CCCCC1COC(=O)CC[C@H](NC(=O)C(Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC2CCCCC2)[C@@H](O)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19721971ML00009249CCCCCCCC[C@@H](C)[C@@H]1OC(=O)[C@H](CO)NC(=O)[C@H](C(=O)c2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(=O)OC)NC(=O)[C@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19731972ML00004370CC[C@H](C)[C@H](NC(=O)[C@@H](CCCCN)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19741973ML00009782CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19751974ML00009727O=C1N[C@H](Cc2ccccc2)COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19761975ML00010498O=C1OC[C@@H]2CCCN2C(=O)[C@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\CC[C@H]1Cc1ccc(F)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19771976ML00002654CC(C)CCCCCCCCCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H]1COC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)[C@@H](C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19781977ML00006231CC[C@H]1OC(=O)[C@H](C)[C@@H](OCc2cn(-c3cccc4ccccc34)nn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19791978ML00008328COc1cc(O)cc2c1C(=O)O[C@@H](C)CC[C@H]1CC[C@H](CC(=O)C2)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19801979ML00009513CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19811980ML00009941CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C[C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19821981ML00005294CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19831982ML00007836C[Se][C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1Ostandard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00007836_numbered.png2026-03-19 06:55:13.658023
19841983ML00008024O=C1CCC/C=C/CCOC(=O)c2c(O)cc(O)c(Cl)c2C1standard_macrolactone13.0success1.0[10]ring_size_13/standard/numbered/ML00008024_numbered.png2026-03-19 06:55:13.683239
19851984ML00009728O=C1N[C@@H](Cc2ccccc2)COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19861985ML00005385CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(O[C@H]2O[C@@H](CO)[C@@H](O)[C@@H](O)[C@@H]2O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19871986ML00000084CHEMBL2373582C[C@H]1CCC/C=C/[C@H]2C[C@H](OC(=O)CN(C)C)C[C@@H]2[C@@H](O)/C=C\C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00000084_numbered.png2026-03-19 06:55:13.732519
19881987ML00010124CC(C)CCC[C@@H]1CC(=O)N[C@H](c2c[nH]c3ccccc23)C(=O)N2CCC[C@H]2NC(=O)[C@@H](CCCNC(=N)N)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19891988ML00009325COc1cc([C@H]2c3c(cc(OC)c(O)c3OC)C=C3C(=O)O[C@H]4[C@H](O)[C@@H](CO)O[C@@]4(CO)O[C@H]4O[C@H](COC(=O)[C@@H]32)[C@@H](O)[C@H](O)[C@H]4O)cc(OC)c1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19901989ML00002705CO[C@H]1[C@H](C)O[C@H](O[C@@H]2[C@@H](OC(C)=O)CO[C@H](O[C@H]3C[C@H]4CC(=O)[C@]5(O)O[C@@H](C[C@@H]5C)C(C)(C)[C@H](/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)[C@H]2OC)[C@@H](OC)[C@@H]1OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19911990ML00008053O=C1CCCCCCC/C=C\CCO1standard_macrolactone13.0success0.0[]ring_size_13/standard/numbered/ML00008053_numbered.png2026-03-19 06:55:13.778511
19921991ML00008743C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])CCN)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00008743_numbered.png2026-03-19 06:55:13.817579
19931992ML00001718CHEMBL1592634O=C1CCC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NCCO1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19941993ML00001058CHEMBL1734306C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H](O)/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00001058_numbered.png2026-03-19 06:55:13.858315
19951994ML00005217CCC(C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC)[C@@H](C)CC)[C@H](C)CC)[C@@H](C)CC)[C@H](C)OC(=O)[C@H]([C@@H](C)CC)NC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19961995ML00003702CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)C(C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([N+](C)(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19971996ML00000777CHEMBL45141CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2CC(N(C)C(C)C)CC(C)O2)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19981997ML00009943CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C[C@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
19991998ML00005457CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20001999ML00008547C/C1=C/C(=O)O[C@@H]2CCN3CC[C@H](COC(=O)[C@@](C)(O)[C@@H](C)C1)[C@H]23non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20012000ML00007666C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](SCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00007666_numbered.png2026-03-19 06:55:13.950836
20022001ML00006908COC(=O)C[C@H]1C[C@@H]2COC(=O)[C@](C)(O)[C@H](C)C/C(C)=C\C(=O)O[C@@H]3CCN1[C@H]23non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20032002ML00008124C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)C(O)C(O)C(=O)O1standard_macrolactone13.0success4.0[3, 11, 12, 13]ring_size_13/standard/numbered/ML00008124_numbered.png2026-03-19 06:55:13.994662
20042003ML00007824O=C1OCCn2cc(F)cc(c2=O)[C@H]2CCCN2c2ccn3ncc1c3n2non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20052004ML00008657C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3C[C@@H](OC1=O)[C@@H](O)[C@@H]23non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20062005ML00003719CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CCF)[C@H]2O)[C@@]2(C)C[C@H](C)[C@H](O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20072006ML00001995CHEMBL2204328CC(C)(C)C(=O)NCCOC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCC(=O)NCCOC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20082007ML00008410CC(=O)O[C@@]1(C)C(=O)OC[C@H]2CC[N+]3([O-])CC[C@@H](OC(=O)/C=C(/C)C[C@H]1C)[C@@H]23non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20092008ML00003666CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CC#N)[C@H]2O)[C@@]2(C)C[C@H](C)[C@H](O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20102009ML00010679CC(C)(C)[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20112010ML00008870CCCC[C@H](C)[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]([C@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20122011ML00002004CHEMBL1438792O=C1NC[C@@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20132012ML00000354CHEMBL409855BEAUVERIOLIDE IIICCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20142013ML00003944C/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCC3C=CC4CC(=O)CC3C42)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00003944_numbered.png2026-03-19 06:55:14.106174
20152014ML00001232CHEMBL1269435CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20162015ML00008552CC(=O)O[C@H]1C[C@H]2/C=C\CCC[C@H](C)OC(=O)/C=C/[C@@H](O)[C@@H]2C1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00008552_numbered.png2026-03-19 06:55:14.142773
20172016ML00007697CCCCC[C@@H]1/C=C\C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O1standard_macrolactone13.0success1.0[3]ring_size_13/standard/numbered/ML00007697_numbered.png2026-03-19 06:55:14.166772
20182017ML00005045CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(=O)NCCN(C)C)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20192018ML00005382CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(-c2ccc(C)cc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20202019ML00001822CHEMBL184615O=C1CCCCCC/C=C2\CC(CO)(CO1)OC2=Ostandard_macrolactone13.0success1.0[4]ring_size_13/standard/numbered/ML00001822_numbered.png2026-03-19 06:55:14.215647
20212020ML00007199CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20222021ML00006955COC(=O)CCS[C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1Ostandard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00006955_numbered.png2026-03-19 06:55:14.256482
20232022ML00006667O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCC[C@H](CCc2ccccc2)O1standard_macrolactone13.0success2.0[3, 11]ring_size_13/standard/numbered/ML00006667_numbered.png2026-03-19 06:55:14.284105
20242023ML00008329COc1cc(O)cc2c1C(=O)O[C@@H](C)CC[C@H]1CC[C@@H](CC(=O)C2)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20252024ML00008304C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](SCCCO)CC(=O)O1standard_macrolactone13.0success3.0[3, 11, 12]ring_size_13/standard/numbered/ML00008304_numbered.png2026-03-19 06:55:14.323330
20262025ML00010996CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](Cc2ccccc2)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20272026ML00006763O=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)NCCOnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20282027ML00005224CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C[C@H]2CNC(=N)N2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20292028ML00004091CCNCC/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00004091_numbered.png2026-03-19 06:55:14.384461
20302029ML00009515CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)C2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20312030ML00008037C/C1=C/CC/C(C)=C\C(=O)OC/C(C)=C\CC1standard_macrolactone13.0success3.0[4, 8, 12]ring_size_13/standard/numbered/ML00008037_numbered.png2026-03-19 06:55:14.423587
20322031ML00008427C=C1CCC(/C=C/C)C(=O)OC2CCN3CC=C(COC(=O)C1(C)O)C23non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20332032ML00002852C/C=C1\CC(c2cc(CO)cc(NCC(O)C3CCCCC3)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00002852_numbered.png2026-03-19 06:55:14.466645
20342033ML00009721C/C=C1\CC(c2cccc(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(O)(CCC)C2CCC(=O)CC2)OC1=Ostandard_macrolactone13.0success3.0[3, 11, 13]ring_size_13/standard/numbered/ML00009721_numbered.png2026-03-19 06:55:14.500632
20352034ML00007810C[C@H]1C[C@@H]2O[C@H]2Cc2ccc(o2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20362035ML00000021CHEMBL1559663C[C@H]1CCC/C=C/C2C[C@H](O)C[C@@]2(O)C/C=C/C(=O)O1standard_macrolactone13.0success2.0[3, 10]ring_size_13/standard/numbered/ML00000021_numbered.png2026-03-19 06:55:14.534819
20372036ML00010428COc1ccc(C[C@H]2NC(=O)[C@]34OC(=O)O/C=C\[C@](C)(O)C(=O)[C@H](C)C/C=C\[C@@H]3[C@H]3O[C@@]3(C)[C@H](C)[C@H]24)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20382037ML00009547CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)[C@@H](O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20392038ML00002258C/C=C1\NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(C)=O)[C@@H](C)OC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20402039ML00005291CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20412040ML00001087CHEMBL1076336O=C(C[C@H]1C/C=C/CCCC(=O)OCCNC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
20422041ML00008781C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])CCO)CC(=O)O1standard_macrol
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