id,ml_id,chembl_id,molecule_name,smiles,classification,ring_size,primary_reason_code,primary_reason_message,processing_status,error_message,num_sidechains,cleavage_positions,numbered_image_path,processed_at
1,ML00000819,CHEMBL1735765,,C[C@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2,ML00003370,,,O=C(C[C@@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@@H]2CCCN2C1=O)N[C@@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3,ML00007631,,,C/C=C1\C(OC2OC(CO)C(O)C(O)C2O)OC=C2C(=O)OCC(C)C3CC(OC(=O)CC21)C(C)C3CO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4,ML00008564,,,C[C@@H]1C[C@](O)([C@@H](C)Cl)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5,ML00004196,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(Oc4c(C(=O)OC[C@H]5O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]5O)cc(O)c(O)c4O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6,ML00009127,,,O=C1NC[C@H](c2ccccc2)OC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7,ML00007255,,,CO[C@H]1/C=C\CC/C=C\C(=O)O[C@@H](/C(C)=C/[C@H](C)C(=O)/C=C/CC2CC(=O)NC(=O)C2)[C@@H](C)[C@@H]1O,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 5, 6]",ring_size_12/standard/numbered/ML00007255_numbered.png,2026-03-19 06:54:43.464482
8,ML00007092,,,C[C@@H]1COC(=O)[C@@H](CC(=O)OC(C)(C)C)C/C=C\C[C@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9,ML00007357,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)CCCCCC/C=C/[C@H]1C,standard_macrolactone,12.0,,,success,,2.0,"[3, 4]",ring_size_12/standard/numbered/ML00007357_numbered.png,2026-03-19 06:54:43.498665
10,ML00010831,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@](C)(O)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010831_numbered.png,2026-03-19 06:54:43.540237
11,ML00008439,,,CC[C@]1(O)C[C@@H](C)[C@](C)(OC(C)=O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
12,ML00008247,,,CC1CCC(O)CCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 6]",ring_size_12/standard/numbered/ML00008247_numbered.png,2026-03-19 06:54:43.571589
13,ML00007684,,,CC(=O)O[C@H]1/C=C/C[C@@H](/C(C)=C/C=C/CC[C@H]2O[C@@H]2C[C@H](C)O)OC(=O)CCCC[C@@]1(C)O,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 8]",ring_size_12/standard/numbered/ML00007684_numbered.png,2026-03-19 06:54:43.604723
14,ML00006968,,,O=C1O[C@@H](c2ccccc2)C[C@@H](O)C(=O)CCCCc2ccccc21,standard_macrolactone,12.0,,,success,,3.0,"[3, 5, 6]",ring_size_12/standard/numbered/ML00006968_numbered.png,2026-03-19 06:54:43.634285
15,ML00010986,,,CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H](CO)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cc(O)c(Br)cc1Br,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
16,ML00009158,,,O=C(Oc1c(O)cc2c(c1O)-c1c(cc(O)c(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](O)[C@H](OC2=O)[C@@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
17,ML00007479,,,C/C(=C\[C@@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@H]1OC(=O)/C=C\CC/C=C\C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,2.0,"[3, 4]",ring_size_12/standard/numbered/ML00007479_numbered.png,2026-03-19 06:54:43.674961
18,ML00008365,,,C=COCOc1cc(O)c2c(c1)CCCCCCC[C@@H](C)OC2=O,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00008365_numbered.png,2026-03-19 06:54:43.696244
19,ML00006718,,,C=C1NC(=O)[C@@H](CCCc2ccc(OC)cc2)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C)NC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
20,ML00008270,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC1=O)[C@@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
21,ML00006916,,,CC(=O)O[C@@]1(C)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC(=O)[C@@](O)([C@@H](C)O)C[C@H]1C)[C@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
22,ML00004204,,,O=C(O)C[C@@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1C(=O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
23,ML00006911,,,CC(=O)O[C@@H]1/C=C\C[C@H](/C(C)=C/C=C/[C@@H](C)O)OC(=O)C[C@H](O)CC[C@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 11]",ring_size_12/standard/numbered/ML00006911_numbered.png,2026-03-19 06:54:43.757866
24,ML00004074,,,O=C1OC[C@@H]2O[C@@H](O)[C@H]3OC(=O)c4cc(O)c(O)c5c4[C@@H]4C(=CC(=O)[C@](O)(O5)C4(O)O)C(=O)O[C@H]2[C@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]2C1=CC(=O)[C@](OC(=O)c1cc(O)c(O)c(O)c1)(O3)C2(O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
25,ML00007454,,,CC/C=C\C=C/C(=O)N/C=C/C[C@@H]1C[C@H](O)[C@H](C)C/C=C\Cc2cccc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 5, 6]",ring_size_12/standard/numbered/ML00007454_numbered.png,2026-03-19 06:54:43.799777
26,ML00001010,CHEMBL2381165,,CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4ccc(I)c(O)c4)O[C@@]1(C3)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
27,ML00007310,,,O=C(C[C@@H]1C/C=C\C[C@H](Cc2ccc(F)cc2)C(=O)OCCNC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
28,ML00008082,,,C[C@@H]1CCCCC[C@H](O)C(=O)[C@H](O)CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 9, 10, 11]",ring_size_12/standard/numbered/ML00008082_numbered.png,2026-03-19 06:54:43.848780
29,ML00008522,,,C=C1C/C(=C\C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@@]1(C)OC(C)=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
30,ML00010295,,,C[C@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
31,ML00010723,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](OC(C)=O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010723_numbered.png,2026-03-19 06:54:43.904336
32,ML00008198,,,C[C@@H]1CCC[C@@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 9]",ring_size_12/standard/numbered/ML00008198_numbered.png,2026-03-19 06:54:43.932907
33,ML00007297,,,O=C(C[C@@H]1C/C=C\CCC(=O)OC[C@H](Cc2ccccc2)NC1=O)N[C@@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
34,ML00008666,,,C/C=C1\C[C@H](C)[C@](C)(O)C(=O)OCC2=CCN3C[C@@H](O)[C@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
35,ML00008211,,,C[C@H]1CCC(=O)[C@@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 6, 7, 9]",ring_size_12/standard/numbered/ML00008211_numbered.png,2026-03-19 06:54:43.978112
36,ML00000775,CHEMBL524666,,O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]2C1=CC(=O)C(O)(O)C2(O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
37,ML00008774,,,C/C=C1\C(=O)O[C@@H]2CCN3CC[C@H](COC(=O)[C@@](C)(O)[C@H](C)[C@@H]1O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
38,ML00007487,,,COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OC[C@H](NC(=O)[C@@H]2CCCN2C(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
39,ML00010905,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)[C@H](C)[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 8, 11, 12]",ring_size_12/standard/numbered/ML00010905_numbered.png,2026-03-19 06:54:44.044200
40,ML00004014,,,O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@@H](O3)[C@@H](OC(=O)c3cc(O)c(O)c4c3[C@H]3C1=CC(=O)C(O)(O)[C@@]3(O)O4)[C@@H]2OC(=O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
41,ML00000379,CHEMBL1730563,,O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
42,ML00008605,,,C/C=C1\C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
43,ML00007359,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CCC[C@@H](O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 7, 11]",ring_size_12/standard/numbered/ML00007359_numbered.png,2026-03-19 06:54:44.099794
44,ML00006882,,,CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@H](OC(=O)[C@@]3(C[C@@H]1C)O[C@@H]3C)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
45,ML00008745,,,CC[C@H]1C(=O)O[C@H]2CCNC/C=C(/COC(=O)[C@@](C)(O)[C@H](C)[C@@H]1O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
46,ML00007463,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)NC[C@@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
47,ML00009978,,,CC[C@H](O)C[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00009978_numbered.png,2026-03-19 06:54:44.159610
48,ML00007833,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)O,standard_macrolactone,12.0,,,success,,8.0,"[3, 4, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007833_numbered.png,2026-03-19 06:54:44.205467
49,ML00002638,,,CC[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002638_numbered.png,2026-03-19 06:54:44.240880
50,ML00003972,,,O=C(O)C[C@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2c(cc(O)c(O)c2O)[C@H]1[C@H](O)C(=O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
51,ML00001032,CHEMBL39858,,CCCCCCC[C@H]1OC(=O)C[C@@H](OCOC)[C@H](Cc2ccccc2)N(C)C(=O)COC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
52,ML00001353,CHEMBL1879879,,C[C@@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
53,ML00001015,CHEMBL39969,,CCCCCCC[C@H]1OC(=O)C[C@@H](OCOC)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C)OC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
54,ML00002272,,,CC(=C/C(C)=C/C[C@@H](O)C[C@H](C)O)/C=C(C)\C=C\C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 6, 8, 9]",ring_size_12/standard/numbered/ML00002272_numbered.png,2026-03-19 06:54:44.304294
55,ML00010699,,,CC/C=C\C=C/CC[C@]1(C)C[C@H](O)[C@H](C)CC[C@H]2C[C@@H](C[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]3OC)C[C@@](O)(CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
56,ML00001034,CHEMBL35924,,CCCCCCC[C@@H]1CC(=O)O[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)[C@H](O)CC(=O)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
57,ML00002341,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](C(C)C)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002341_numbered.png,2026-03-19 06:54:44.351353
58,ML00008565,,,C[C@@H]1C[C@](O)([C@@H](C)Cl)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
59,ML00008257,,,C/C=C1/CC[C@@](C)(OC(C)=O)C(=O)OC[C@@]2(O)CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
60,ML00002410,,,COC(=O)[C@H]1OC(=O)c2cc(O)c(O)c(O)c2[C@@H]1[C@H](CC(=O)O)C(=O)O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@@H](O)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
61,ML00009125,,,O=C(Oc1c(O)cc(C(=O)O[C@@H]2O[C@@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]([C@H]2O)[C@@H]3O)cc1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
62,ML00007861,,,C/C=C1/C[C@]2(CO2)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
63,ML00000727,CHEMBL1714949,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
64,ML00008555,,,CCOc1cc(O)c2c(c1)CCCCCCC[C@@H](C)OC2=O,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00008555_numbered.png,2026-03-19 06:54:44.416031
65,ML00001184,CHEMBL3260944,,CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)/C(C)=C\CCc3coc(/C=C\CNC(=O)OC)n3)C[C@H](CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
66,ML00010864,,,CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@@]3(O)CC(=O)O[C@](C)(CC/C=C/C=C/Br)C[C@@H](O)[C@H](C)CC[C@H](O3)[C@@H]2C)[C@H](O)[C@@H]1OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
67,ML00004305,,,CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](C)(O)[C@H]3O[C@@H]3O[C@@H](C)[C@H](O)[C@@](C)(O)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
68,ML00008372,,,C=CCOc1cc(O)c2c(c1)CCCCCCC[C@@H](C)OC2=O,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00008372_numbered.png,2026-03-19 06:54:44.457364
69,ML00008110,,,CO[C@H]1CC(=O)C/C=C\[C@@H](O)CC(=O)O[C@H](C)C1,standard_macrolactone,12.0,,,success,,4.0,"[3, 5, 7, 11]",ring_size_12/standard/numbered/ML00008110_numbered.png,2026-03-19 06:54:44.488612
70,ML00008595,,,C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
71,ML00010832,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010832_numbered.png,2026-03-19 06:54:44.535162
72,ML00002485,,,C=C[C@H]1[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OCC[C@@H]3C(=CO[C@@H](O[C@H]4O[C@@H](CO)[C@H](OC(=O)/C=C/c5ccc(O)cc5)[C@@H](O)[C@@H]4O)[C@@H]3C=C)C(=O)OCC[C@H]21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
73,ML00007829,,,C[C@H]1C[C@H](C)[C@H](O)[C@H](C)C(=O)O[C@H]([C@H](C)O)[C@@H](C)/C=C\C1=O,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007829_numbered.png,2026-03-19 06:54:44.584981
74,ML00009409,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3O[C@@](O)(C2)[C@H](C)C(=O)O[C@@H](/C=C/C=C/Br)C/C(C)=C\C(=O)C3(C)C)[C@H](OC)[C@@H]1O[C@@H]1O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]1OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
75,ML00010323,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@@H]3CC[C@@H](C)[C@H](O)C[C@@](C)(/C=C/C=C\Br)OC(=O)C[C@](O)(C2)O3)[C@H](OC)[C@@H]1OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
76,ML00002100,CHEMBL3260943,,CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)CCCCc3coc(CCCNC(=O)OC)n3)C[C@H](CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
77,ML00008594,,,C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
78,ML00009042,,,CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@H]3[C@@H]4C=C5C(=O)[C@H](C)[C@@H](O)CCC[C@H](/C=C/[C@H](C)O)OC(=O)C[C@H]5[C@@H]4C=C[C@@H]3[C@@H]2O)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00009042_numbered.png,2026-03-19 06:54:44.645027
79,ML00004199,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]3[C@H]1OC(=O)c1cc(O)c(O)c(O)c1[C@H]1C(=O)[C@H](O)C[C@@]1(O)C(=O)O[C@@H]32)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
80,ML00006869,,,CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@@](O)([C@@H](C)Cl)C[C@H]1C)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
81,ML00009097,,,O=C1OC[C@@H]2O[C@H](OC(=O)c3cc(O)c(O)c(O)c3-c3c1cc(O)c(O)c3O)[C@H]1OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]1[C@H]2O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
82,ML00008021,,,C[C@H]1CCC(=O)[C@@H]2CC(=O)c3c(cc(O)cc3O2)CC(=O)O1,non_standard_macrocycle,12.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
83,ML00008484,,,C=C1C(=O)O[C@H]2CC(=O)n3ccc(c32)COC(=O)[C@](C)(OC(C)=O)[C@@H](C)[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
84,ML00002949,,,CC(=O)C[C@]1(O)C(=O)C=C2C(=O)O[C@H]3[C@@H]4OC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)OC[C@H]3O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]4OC(=O)c3cc(O)c(O)c4c3[C@H]2[C@@]1(O)O4,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
85,ML00006623,,,CCCCC[C@@H]1OC(=O)c2cc(ccc2C)Oc2ccc(O)c(C=O)c2/C=C\[C@@H]1O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
86,ML00004283,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](C)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00004283_numbered.png,2026-03-19 06:54:44.726804
87,ML00000725,CHEMBL1551810,,CC(C)(C)[C@@H]1COC(=O)[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
88,ML00009156,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
89,ML00002473,,,CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H](O[C@@H]4O[C@@H](C)[C@H](O)[C@@](C)(O)[C@H]4OC)[C@@](C)(O)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
90,ML00001634,CHEMBL3215313,,C=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2C2C(O)(O3)C3(O)OC4(C(=O)OC5C(O)COC54O)C12CC3=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
91,ML00008381,,,C[C@@H]1C(=O)OCC(=O)N(C)[C@@H](Cc2ccccc2)[C@@H](O)CC(=O)O[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
92,ML00002486,,,C=C[C@H]1[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OCC[C@@H]3C(=CO[C@@H](O[C@H]4O[C@@H](CO)[C@H](OC(=O)/C=C\c5ccc(O)cc5)[C@@H](O)[C@@H]4O)[C@@H]3C=C)C(=O)OCC[C@H]21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
93,ML00009399,,,COc1cc2cc(c1Cl)N1CC(=O)C(C)(O)C(=O)N(C)C(C)C(=O)O[C@@H](CC1=O)[C@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C/C=C(\C)C2OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
94,ML00007486,,,COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OCC(NC(=O)[C@H]2C(O)CCN2C(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
95,ML00008617,,,C/C=C1/C[C@@H](C)[C@@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
96,ML00008568,,,C[C@@H]1C[C@@]2(C)CC(=O)O[C@@H]3CCN4CC[C@H](COC(=O)[C@]1(C)O2)[C@H]34,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
97,ML00001977,CHEMBL1727544,,O=C(C[C@@H]1C/C=C\C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@@H](Cc2ccccc2)NC1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
98,ML00010760,,,CCC(=O)/C(C)=C/[C@H](O)C[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010760_numbered.png,2026-03-19 06:54:44.843963
99,ML00007378,,,CC[C@H]1O[C@H]1C[C@](C)(O)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00007378_numbered.png,2026-03-19 06:54:44.883966
100,ML00002847,,,C=C[C@@H]1[C@@H]2[C@@H]3/C=C\CC(=O)O[C@@]45C[C@@H](C)[C@@]6(O)[C@@H](C=C(CO)C[C@]7(O)C(=O)C(C)=C[C@H]76)[C@@H]4[C@@]5(C)COC(=O)[C@H]3[C@@H](/C=C/C=C/C=C/C=C/CCC)[C@@H]21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
101,ML00001002,CHEMBL1079558,,O=C(C[C@H]1C/C=C/CCC(=O)O[C@@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
102,ML00010904,,,CCC(=O)O[C@H]1/C=C\[C@H](C)[C@H](/C(C)=C/C=C/[C@H](C)C[C@H]2O[C@@H]2[C@H](C)[C@@H](O)CC)OC(=O)C[C@H](O)CC[C@]1(C)O,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010904_numbered.png,2026-03-19 06:54:44.936867
103,ML00007464,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)NC[C@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
104,ML00008654,,,C/C=C1/C[C@@H](C)[C@@H](O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
105,ML00010145,,,C[C@@H]1CCCCCCCc2cc(OC(=O)c3ccc(Br)cc3)cc(OC(=O)c3ccc(Br)cc3)c2C(=O)O1,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00010145_numbered.png,2026-03-19 06:54:44.971139
106,ML00008632,,,C/C=C1/C[C@H](C)[C@](C)(O)C(=O)OCC2=CCN3CC[C@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
107,ML00002069,CHEMBL3623739,,O=C(C#Cc1ccccc1)N/C=C/C[C@H]1C[C@@H](O)CC/C=C/Cc2cccc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 5]",ring_size_12/standard/numbered/ML00002069_numbered.png,2026-03-19 06:54:45.003918
108,ML00009099,,,O=C1OCC(O)C(C2OC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)c4c3C(=O)OC2C4O)OC(=O)c2cc(O)c(O)c(O)c2-c2cc1c(O)c(O)c2O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
109,ML00010687,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
110,ML00002129,CHEMBL1669768,,Cc1ccc(S(=O)(=O)Oc2cc3c(c(OS(=O)(=O)c4ccc(C)cc4)c2)C(=O)O[C@H](C)CCCCCCC3)cc1,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00002129_numbered.png,2026-03-19 06:54:45.041277
111,ML00009147,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)CO[C@H]([C@H]1O)[C@@H]2OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
112,ML00008590,,,C/C=C1/C[C@@H](C)[C@](C)(O)C(=O)OC[C@H]2CCN3CC[C@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
113,ML00000521,CHEMBL1710965,,O=C(N[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)OC1=O)OCC1c2ccccc2-c2ccccc21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
114,ML00007427,,,CC/C=C\C=C/C(=O)N/C=C\C[C@H]1C[C@@H](O)[C@@H](C)C/C=C/Cc2ccc(F)c(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 5, 6]",ring_size_12/standard/numbered/ML00007427_numbered.png,2026-03-19 06:54:45.091327
115,ML00004086,,,CC(C)(C)[C@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
116,ML00008195,,,C[C@@H]1CCC[C@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 9]",ring_size_12/standard/numbered/ML00008195_numbered.png,2026-03-19 06:54:45.127160
117,ML00008761,,,C[C@H]1C[C@@](O)([C@H](C)O)C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
118,ML00010273,,,CC[C@H](O)[C@@H](C)[C@@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010273_numbered.png,2026-03-19 06:54:45.173716
119,ML00010194,,,O=C(C[C@@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](Cc2c[nH]c3ccccc23)NC1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
120,ML00008708,,,C/C=C1\C(=O)OC2CCN3CCC(COC(=O)C(C)(O)C(C)C1O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
121,ML00006642,,,C=C(C#N)CO[C@@H]1O[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]([C@@H]1O)[C@@H]2O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
122,ML00010903,,,CC(=O)O[C@H]1/C=C\[C@H](C)[C@@H](/C(C)=C/C=C/[C@H](C)C[C@@H](C)/C=C(\C)[C@H](O)[C@H](C)O)OC(=O)C[C@@H](O)CC[C@@]1(C)O,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010903_numbered.png,2026-03-19 06:54:45.233506
123,ML00008557,,,COc1cc2c(c(OC)c1)C(=O)O[C@H](C)CCCCCCC2,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00008557_numbered.png,2026-03-19 06:54:45.256640
124,ML00006605,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)N2CCC[C@@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
125,ML00007531,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H]([N+](C)(C)[O-])[C@@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)O,standard_macrolactone,12.0,,,success,,8.0,"[3, 4, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007531_numbered.png,2026-03-19 06:54:45.310686
126,ML00010688,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](c2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
127,ML00010465,,,CCC[C@@H]1OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)C(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
128,ML00001862,CHEMBL1606783,,CC(=O)C[C@H](O)CC(=O)[C@H]1OC(=O)CCCCCCCc2ccccc21,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00001862_numbered.png,2026-03-19 06:54:45.345929
129,ML00002795,,,CC/C=C/[C@H]1CCC[C@H](O[C@H]2C[C@@H](OC)[C@H](OC)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)[C@@H](O)[C@H]4C=C[C@H]3[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002795_numbered.png,2026-03-19 06:54:45.382052
130,ML00007542,,,CC[C@H]1OC(=O)[C@@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@H](C)C(=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007542_numbered.png,2026-03-19 06:54:45.425827
131,ML00004056,,,O=C1C[C@]2(O)OC(=O)[C@H](OC1=O)[C@H]2c1c(C(=O)O[C@H]2[C@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@@H](O[C@@H]2OC(=O)c2cc(O)c(O)c(O)c2)[C@H]3O)cc(O)c(O)c1O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
132,ML00004067,,,O=C(O)C[C@@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]1[C@H](O)C(=O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
133,ML00008644,,,C/C=C1/C[C@@H](C)[C@@](O)(CO)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
134,ML00008585,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
135,ML00008300,,,C/C=C1/C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC1=O)[C@@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
136,ML00007794,,,COc1cc(O)cc2c1C(=O)O[C@H](C)[C@@H](O)CCCCCC2,standard_macrolactone,12.0,,,success,,2.0,"[3, 4]",ring_size_12/standard/numbered/ML00007794_numbered.png,2026-03-19 06:54:45.488282
137,ML00008471,,,C/C=C1/C[C@H](C)[C@@](C)(OC(C)=O)C(=O)OCc2ccn3c2[C@H](CC3=O)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
138,ML00002692,,,CCC(=O)C[C@H](O)C/C=C(C)/C=C(C)/C=C(C)/C=C/C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 6, 8, 9]",ring_size_12/standard/numbered/ML00002692_numbered.png,2026-03-19 06:54:45.527865
139,ML00007870,,,C=C1C(=O)OCC2=CCN3CC[C@@H](OC(=O)[C@](C)(O)[C@]4(CO4)[C@H]1C)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
140,ML00000993,CHEMBL8097,,CCCCCCC[C@H]1OC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C)OC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
141,ML00002404,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](C6CC6)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002404_numbered.png,2026-03-19 06:54:45.575450
142,ML00010205,,,CCC(O)C(C)C1OC1CC(C)/C=C/C=C(/C)C1OC(=O)CC(O)CCC(C)(O)C(O)CCC1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010205_numbered.png,2026-03-19 06:54:45.615957
143,ML00006927,,,CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@@](O)([C@@H](C)O)C[C@H]1C)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
144,ML00008606,,,C[C@]1(O)C[C@]2(C)CC(=O)O[C@@H]3CCN4CC=C(COC(=O)[C@@]1(C)O2)[C@H]34,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
145,ML00008569,,,C/C=C1/C(=O)O[C@@H]2CCN3CC[C@H](COC(=O)[C@@](C)(O)[C@H](C)[C@@H]1O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
146,ML00001884,CHEMBL1094534,PAECILOMYCIN B,COc1cc(O)c2c(c1)[C@@H]1O[C@@H]([C@@H](O)C[C@H]1O)[C@H](O)/C=C/C[C@H](C)OC2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
147,ML00004071,,,O=C(O[C@@H]1[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC[C@@H](O2)[C@H]1OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
148,ML00000386,CHEMBL1730133,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
149,ML00002723,,,CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H]([N+](C)(C)[O-])[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002723_numbered.png,2026-03-19 06:54:45.690948
150,ML00009696,,,COc1cc2cc(c1Cl)N1CC(=O)[C@@](C)(O)C(=O)N(C)[C@@H](C)C(=O)O[C@@H](CC1=O)[C@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C\C=C(\C)C2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
151,ML00010191,,,C[C@@H]1CCCCCCCc2cc(OCc3ccccc3)cc(OCc3ccccc3)c2C(=O)O1,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00010191_numbered.png,2026-03-19 06:54:45.720666
152,ML00004051,,,O=C(O)C[C@@H]1C(=O)O[C@@H]2[C@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]2[C@@H](OC(=O)c2cc(O)c(O)c4c2[C@@H]1[C@@](O)(C(=O)O)O4)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
153,ML00004020,,,O=C(O)/C=C(\C(=O)O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@H](O)[C@@H](OC(=O)c1cc(O)c(O)c(O)c1)O2)[C@H]1c2c(cc(O)c(O)c2O)C(=O)O[C@H]1C(=O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
154,ML00002787,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](c6ccoc6)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002787_numbered.png,2026-03-19 06:54:45.774025
155,ML00008417,,,CC[C@@]1(O)C[C@@H](C)[C@@](C)(OC(C)=O)C(=O)OCC2=CC(=O)N3CC[C@@H](OC1=O)[C@@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
156,ML00008377,,,C=C1C/C(=C\C)C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@]1(C)O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
157,ML00008500,,,COC(=O)[C@@]1(O)CS[C@H]2CCC[C@H](C)OC(=O)Cc3cc(O)cc(O)c3C(=O)[C@@H]21,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00008500_numbered.png,2026-03-19 06:54:45.819961
158,ML00004010,,,O=C(O)/C=C(\C(=O)O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@@H](O)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O2)[C@H]1c2c(cc(O)c(O)c2O)C(=O)O[C@H]1C(=O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
159,ML00007866,,,C/C=C1/C[C@]2(CO)O[C@@]2(C)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
160,ML00008207,,,CC1CCCCCC(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00008207_numbered.png,2026-03-19 06:54:45.861140
161,ML00009043,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](/C=C/[C@H](C)O)CCC[C@H](O)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00009043_numbered.png,2026-03-19 06:54:45.894390
162,ML00009128,,,O=C(C[C@H]1C/C=C\C[C@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
163,ML00008618,,,C/C=C1/C[C@H](C)[C@@](O)(CO)C(=O)OCC2=CCN3CC[C@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
164,ML00008068,,,C[C@@H]1C[C@H](O)CC(=O)C/C=C\[C@@H](O)CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 5, 7, 11]",ring_size_12/standard/numbered/ML00008068_numbered.png,2026-03-19 06:54:45.940038
165,ML00007556,,,CC[C@H](O)[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@H](C)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,5.0,"[3, 4, 7, 8, 11]",ring_size_12/standard/numbered/ML00007556_numbered.png,2026-03-19 06:54:45.976391
166,ML00010835,,,CC(=O)O[C@H]1/C=C\[C@H](C)[C@H](/C(C)=C/C=C/[C@@H](C)C[C@H](O)[C@H]2O[C@H](C)[C@@H](O)[C@@H]2C)OC(=O)C[C@H](O)CC[C@]1(C)O,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010835_numbered.png,2026-03-19 06:54:46.017420
167,ML00004013,,,O=C1O[C@H]2[C@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H](OC(=O)c3cc(O)c(O)c4c3[C@@H]3C1=CC(=O)[C@](O)(O4)C3(O)O)[C@@H]1OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC[C@H]2O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
168,ML00007917,,,COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OC[C@H](NC(C)=O)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
169,ML00007581,,,O=C(OC1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC(C2O)C1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
170,ML00009979,,,CC(=O)O[C@H]1/C=C\[C@H](C)[C@H](/C(C)=C/C=C/[C@H](C)C[C@@H]2O[C@@H]2[C@H](C)[C@H](C)O)OC(=O)C[C@H](O)CC[C@@]1(C)O,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00009979_numbered.png,2026-03-19 06:54:46.080301
171,ML00007171,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)N[C@@H](Cc2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
172,ML00004054,,,O=C(O)C[C@]12OC(=O)[C@H](OC1=O)[C@H]2c1c(C(=O)O[C@H]2[C@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@@H](O[C@@H]2OC(=O)c2cc(O)c(O)c(O)c2)[C@H]3O)cc(O)c(O)c1O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
173,ML00008627,,,C[C@@H]1[C@@H](O)[C@]2(C)CC(=O)O[C@@H]3CCN4CC=C(COC(=O)[C@@]1(C)O2)[C@H]34,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
174,ML00010861,,,CCC(=O)[C@H](C)[C@H]1O[C@@H]1C[C@](C)(O)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010861_numbered.png,2026-03-19 06:54:46.142139
175,ML00007584,,,O=C(OC1C(O)C2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC(O2)C1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
176,ML00008490,,,C=C1C/C(=C\C)C(=O)O[C@@H]2CC(=O)n3ccc(c32)COC(=O)[C@]1(C)OC(C)=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
177,ML00008670,,,C=C1C/C(=C/C)C(=O)O[C@@H]2CCN3C[C@H](O)[C@@H](COC(=O)[C@]1(C)O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
178,ML00009500,,,O=C1OC[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@H]1Cc1ccc(F)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
179,ML00006691,,,CO[C@@H]1[C@@H](CO)O[C@@H](Oc2c(O)cc3c(c2O)C(=O)CCCCC[C@H](C)OC(=O)C3)[C@H](O)[C@H]1O,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00006691_numbered.png,2026-03-19 06:54:46.194926
180,ML00004200,,,O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]3[C@@H]2OC(=O)[C@]2(O)C[C@H](O)C(=O)[C@H]2c2c(cc(O)c(O)c2O)C(=O)O[C@H]31)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
181,ML00007635,,,C/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OC[C@H](C)[C@@H]3C[C@H](O)[C@H](C)[C@H]3COC(=O)C[C@H]21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
182,ML00007582,,,O=C(O[C@@H]1[C@@H](O)[C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC[C@@H](O2)[C@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
183,ML00000979,CHEMBL1159467,E181,O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(Oc5c(C(=O)O)cc(O)c(O)c5O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2C2C1=CC(=O)C(O)(O)C2(O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
184,ML00007789,,,COc1cc(O)cc2c1C(=O)O[C@H](C)C[C@@H](O)CCCCC2,standard_macrolactone,12.0,,,success,,2.0,"[3, 5]",ring_size_12/standard/numbered/ML00007789_numbered.png,2026-03-19 06:54:46.250862
185,ML00008597,,,C/C=C1\C[C@H](C)[C@@](C)(O)C(=O)OC[C@@H]2CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
186,ML00008655,,,C/C=C1\C[C@@H](C)[C@@H](O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
187,ML00000322,CHEMBL4062982,,CC(/C=C/C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(\C)C[C@@H]1C)=C\[C@@H](C)C/C=C/C(C)=C/[C@H](O)[C@@H](O)C[C@H](C)O,standard_macrolactone,12.0,,,success,,4.0,"[3, 6, 8, 9]",ring_size_12/standard/numbered/ML00000322_numbered.png,2026-03-19 06:54:46.297022
188,ML00001202,CHEMBL3260941,,CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)CCCCc3coc(/C=C\CNC(=O)OC)n3)C[C@H](CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
189,ML00008217,,,C[C@H]1CC[C@@H](O)/C=C\C(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 6, 9]",ring_size_12/standard/numbered/ML00008217_numbered.png,2026-03-19 06:54:46.332466
190,ML00007813,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007813_numbered.png,2026-03-19 06:54:46.375056
191,ML00008559,,,CC/C=C\CCC(=O)[C@@H]1/C=C\C/C=C\CCCCC(=O)O1,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00008559_numbered.png,2026-03-19 06:54:46.396958
192,ML00010105,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)/C=C\[C@]2(CO2)[C@H](OC(C)=O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 7, 11]",ring_size_12/standard/numbered/ML00010105_numbered.png,2026-03-19 06:54:46.430600
193,ML00008255,,,C/C=C1\C[C@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
194,ML00002807,,,CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@H]3[C@@H]4C=C5C(=O)[C@H](C)[C@@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)CCC[C@H](C6CC6)OC(=O)C[C@H]5[C@@H]4C=C(C)[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002807_numbered.png,2026-03-19 06:54:46.473094
195,ML00008516,,,COC(=O)[C@@H]1CSCc2ccccc2C(=O)OCC(NC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
196,ML00005329,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(=O)NCCCC[C@H](NC(=O)c2ccc(C3(C(F)(F)F)N=N3)cc2)C(=O)N(C)CCN(C)C(=O)CCCC[C@H]2SC[C@H]3NC(=O)N[C@H]32)/C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00005329_numbered.png,2026-03-19 06:54:46.527174
197,ML00008662,,,C/C=C1/C[C@H](C)[C@](C)(O)C(=O)OCC2=CCN3C[C@@H](O)[C@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
198,ML00007113,,,C[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
199,ML00009977,,,CC[C@H](O)[C@@H](C)[C@@H]1O[C@@H]1CC/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00009977_numbered.png,2026-03-19 06:54:46.579542
200,ML00007516,,,CC(C)(C)[C@H]1COC(=O)CC/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
201,ML00007529,,,CC[C@@H](C)[C@H]1NC(=O)[C@@H](C)[C@@H](O)C[C@H]([C@H](C)CCCC[C@H](C)O)OC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
202,ML00004076,,,O=C1OC[C@@H]2O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@@H]3[C@@H]2OC(=O)c2cc3c(c(O)c2O)O[C@]2(O)C(=O)C=C1[C@H]3C2(O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
203,ML00006689,,,CCCC[C@@H]1COC(=O)[C@H](CC(=O)NCc2ccc(Cl)cc2)C/C=C/CCC(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
204,ML00002088,CHEMBL1396521,,O=C1OC[C@@H]2CCCN2C(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@@H]1Cc1ccc(F)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
205,ML00004207,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]([C@@H]1O)[C@@H]2OC(=O)[C@H]1CC(=O)c2oc(=O)c3cc(O)c(O)c(O)c3c21)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
206,ML00001703,CHEMBL2152356,,O=C(C[C@@H]1C/C=C/CCC(=O)OC[C@@H]2CCCN2C1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
207,ML00010635,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
208,ML00001056,CHEMBL3400935,,C/C1=C\CCC(C)C(C)OC(=O)Cc2c(Cl)c(O)cc(O)c2C1=O,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 8, 9]",ring_size_12/standard/numbered/ML00001056_numbered.png,2026-03-19 06:54:46.666715
209,ML00010545,,,CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@@H](C)O)OC(=O)/C=C(\O2)[C@](C)(O)CC3(C)C)[C@@H]1C)c1cccc(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
210,ML00008599,,,C/C=C1\C[C@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
211,ML00008664,,,C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3C[C@@H](O)[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
212,ML00006867,,,C/C=C1/C[C@@H](COC(C)=O)[C@@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
213,ML00006676,,,CO/N=C/C=C\C(=O)NC/C=C/[C@@H]1OC(=O)c2c(O)cccc2/C=C\C=C/[C@H]2O[C@H]2[C@@H]1O,standard_macrolactone,12.0,,,success,,2.0,"[3, 4]",ring_size_12/standard/numbered/ML00006676_numbered.png,2026-03-19 06:54:46.722258
214,ML00001250,CHEMBL1714837,,CC(C)(C)[C@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
215,ML00009518,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@]2(C)C[C@@H](C)[C@@]3(O2)O[C@@]1(C)[C@H](O)[C@H]3C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
216,ML00007773,,,O=C(C[C@@H]1C/C=C\CCC(=O)OC[C@@H]2CCCN2C1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
217,ML00008630,,,C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
218,ML00003916,,,CC/N=C1/O[C@H]2[C@H](O[C@@H]3[C@@H](C)[C@H](O[C@H]4C[C@@](C)(OC)[C@@H](O)[C@H](C)O4)[C@@H](C)C(=O)O[C@H](CC)[C@@]4(C)OC5(O[C@@]3(C)C[C@H]5C)[C@H](C)[C@@H]4C)O[C@H](C)C[C@@H]2N1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
219,ML00002350,,,CC[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@H]4C(C)=C[C@H]3[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002350_numbered.png,2026-03-19 06:54:46.791420
220,ML00008204,,,C[C@@H]1CCC(=O)CCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 6]",ring_size_12/standard/numbered/ML00008204_numbered.png,2026-03-19 06:54:46.817748
221,ML00008206,,,C[C@H]1CCCCCC(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00008206_numbered.png,2026-03-19 06:54:46.844851
222,ML00007577,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]([C@H]2O)[C@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
223,ML00001932,CHEMBL1534142,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
224,ML00010415,,,C[C@@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
225,ML00007093,,,C[C@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
226,ML00001748,CHEMBL2152364,,C[C@H]1C/C=C\C[C@@H](CC(=O)NCc2ccc(Cl)cc2)C(=O)OC[C@@H](c2ccccc2)NC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
227,ML00007658,,,C/C(=C\[C@H](C)C(=O)CCCC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\C[C@@H](O)[C@@H]1C,standard_macrolactone,12.0,,,success,,3.0,"[3, 4, 5]",ring_size_12/standard/numbered/ML00007658_numbered.png,2026-03-19 06:54:46.914199
228,ML00007360,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C/[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00007360_numbered.png,2026-03-19 06:54:46.960640
229,ML00006750,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@H](NC)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)O,standard_macrolactone,12.0,,,success,,8.0,"[3, 4, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00006750_numbered.png,2026-03-19 06:54:47.012238
230,ML00008254,,,C/C=C1\C[C@H](C)[C@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
231,ML00002951,,,CC(=O)C[C@]1(O)C(=O)C=C2C(=O)O[C@H]3[C@@H]4OC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)OC[C@H]3O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]4OC(=O)c3cc(O)c(O)c4c3[C@H]2[C@]1(O)O4,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
232,ML00007474,,,C/C(=C\[C@H](C)C(=O)/C=C/CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\[C@H](O)[C@@H](O)[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 5, 6]",ring_size_12/standard/numbered/ML00007474_numbered.png,2026-03-19 06:54:47.080276
233,ML00009132,,,O=C1O[C@H](c2ccccc2)CNC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@H]1Cc1ccc(F)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
234,ML00002990,,,O=C(C[C@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@H](Cc2ccccc2)NC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
235,ML00002848,,,C=C/C=C\[C@H]1[C@H]2[C@@H](/C=C/C=C/C=C/CCC)[C@H]2[C@@H]2C(=O)OC[C@]3(C)[C@H]4[C@@H]5C=C(CO)C[C@]6(O)C(=O)C(C)=C[C@H]6[C@@]5(O)[C@H](C)C[C@]43OC(=O)C/C=C\[C@H]12,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
236,ML00010976,,,CC1=C2CC(=O)O[C@@H]([C@@H](C)O)CC(=O)O[C@H]3C[C@@](O2)(O[C@H]([C@@H](C)CCCc2cccc(O)c2)[C@H]3C)C(C)(C)C1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
237,ML00008323,,,CCCOc1cc(O)c2c(c1)CCCCCCC[C@@H](C)OC2=O,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00008323_numbered.png,2026-03-19 06:54:47.134006
238,ML00006800,,,C=CCNC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OC[C@H](NC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
239,ML00008631,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
240,ML00006883,,,CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@]3(C[C@@H]1C)O[C@@H]3C)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
241,ML00007363,,,CC[C@H](O)[C@H](O)C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00007363_numbered.png,2026-03-19 06:54:47.195351
242,ML00008159,,,COC1CCCC(C)OC(=O)Cc2cc(O)cc(O)c2C(=O)C1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 9]",ring_size_12/standard/numbered/ML00008159_numbered.png,2026-03-19 06:54:47.227446
243,ML00006714,,,C/C=C1\C(=O)O[C@H]2CCN(C)C/C=C(/COC(=O)[C@@](C)(OC(C)=O)[C@@H](C)[C@@H]1OC(C)=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
244,ML00007481,,,C/C(=C\[C@H](C)C(=O)/C=C/CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\C[C@@H](O)[C@@H]1C,standard_macrolactone,12.0,,,success,,3.0,"[3, 4, 5]",ring_size_12/standard/numbered/ML00007481_numbered.png,2026-03-19 06:54:47.266521
245,ML00007430,,,CC/C=C\C=C/C(=O)N/C=C\C[C@H]1C[C@H](O)[C@H](C)C/C=C\Cc2cccc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 5, 6]",ring_size_12/standard/numbered/ML00007430_numbered.png,2026-03-19 06:54:47.297783
246,ML00006756,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@H](NC)[C@@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00006756_numbered.png,2026-03-19 06:54:47.344803
247,ML00008268,,,C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC1=O)[C@@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
248,ML00007634,,,C/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OC[C@H](C)[C@@H]3[C@@H](O)C[C@H](C)[C@H]3COC(=O)C[C@H]21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
249,ML00010611,,,COc1ccc([C@@H]2Cc3cc(O)cc(O)c3C(=O)O[C@H](c3ccc(O)cc3)Cc3cc(OC)cc(O)c3C(=O)O2)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
250,ML00009695,,,COc1cc2cc(c1Cl)N1CC(=O)C(C)(O)C(=O)N(C)[C@@H](C)C(=O)O[C@@H](CC1=O)[C@@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C/C=C(\C)C2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
251,ML00008853,,,CO[C@@H]1/C=C(/C)C[C@H](/C=C/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)C[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H]4NC(=O)O[C@@]4(C)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
252,ML00008102,,,Cc1c(O)cc(O)c2c1C(=O)OCCC(=O)NCCSC2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
253,ML00008386,,,COc1cc(O)c2c(c1)[C@@H]1O[C@@H]([C@@H](O)C[C@H]1O)[C@H](O)/C=C\C[C@H](C)OC2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
254,ML00008603,,,C[C@@H]1[C@@H](C)[C@](O)(CCl)C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
255,ML00000973,CHEMBL412564,,CC(=O)O[C@H]1[C@@H]2CO[C@@H]2[C@@H]2OCOCCOC(=O)O[C@H]3C(=O)[C@@]2(C)[C@@H]1[C@H](OC(=O)c1ccccc1)[C@]1(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c2ccccc2)c2ccccc2)C(C)=C3C1(C)C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
256,ML00007852,,,C=C1C[C@](O)([C@H](C)Cl)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
257,ML00010802,,,O=C(C[C@@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
258,ML00010859,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC(=O)[C@@](C)(O)[C@H](OC(C)=O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 8, 9, 11]",ring_size_12/standard/numbered/ML00010859_numbered.png,2026-03-19 06:54:47.471706
259,ML00009344,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
260,ML00001102,CHEMBL1159468,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(Oc4c(C(=O)O)cc(O)c(O)c4O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
261,ML00010684,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
262,ML00010957,,,CCNC(=O)O[C@H]1/C=C/[C@H](C)[C@@H](/C(C)=C/C=C/[C@@H](C)C[C@H]2O[C@@H]2[C@H](C)[C@@H](O)CC)OC(=O)C[C@H](O)CC[C@@]1(C)O,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010957_numbered.png,2026-03-19 06:54:47.539280
263,ML00004026,,,O=C1C=C2C(=O)O[C@H]3[C@H](OC(=O)c4cc(O)c(O)c(O)c4)O[C@@H]4COC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)O[C@H]3[C@@H]4OC(=O)c3cc(O)c(O)c(O)c3[C@@H]2C(O)(O)C1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
264,ML00010074,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
265,ML00007034,,,C=C1NC(=O)[C@H](CCCc2ccc(O)cc2)NC(=O)[C@H](C(C)C)OC(=O)[C@H](C)NC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
266,ML00008073,,,C[C@H]1CCC[C@@H](O)/C=C\[C@H](O)/C=C\C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 10]",ring_size_12/standard/numbered/ML00008073_numbered.png,2026-03-19 06:54:47.593156
267,ML00002378,,,CCC1CCCC(OC2CCC(N(C)C)C(C)O2)C(C)C(=O)C2=CC3C(C=C(C)C4CC(OC5OC(C)C(OC)C(OC)C5OC)CC43)C2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002378_numbered.png,2026-03-19 06:54:47.628265
268,ML00001252,CHEMBL1700973,,CC(C)(C)[C@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
269,ML00008171,,,C[C@@H]1C/C=C/CCC(=O)N[C@H](c2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
270,ML00007033,,,CC(=O)N1C(=O)SC[C@H]1C(=O)/C=C/C[C@H]1CC[C@H](C)/C=C\CC/C(C)=C\C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 6, 11]",ring_size_12/standard/numbered/ML00007033_numbered.png,2026-03-19 06:54:47.673279
271,ML00001927,CHEMBL1725121,,O=C1N[C@@H](c2ccccc2)COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
272,ML00008545,,,C/C=C1\CC(C)C(C)C(=O)OCC2CCN3CCC(OC1=O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
273,ML00008262,,,C/C=C1\C[C@@H](C)[C@](O)(CO)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
274,ML00008764,,,C[C@@H]1[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC(=O)[C@@]1(O)CO)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
275,ML00008279,,,C=C1C[C@@H](CC)C(=O)O[C@@H]2CC[C@]3(C)CC=C(COC(=O)[C@@]1(C)O)[N+]23[O-],non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
276,ML00008248,,,C[C@H]1CCCCC[C@H](O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00008248_numbered.png,2026-03-19 06:54:47.731121
277,ML00008933,,,O=C(C[C@@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](Cc2ccccc2)NC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
278,ML00000401,CHEMBL288124,,CCCCCCC[C@H]1OC(=O)C[C@H](OCOC)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
279,ML00002278,,,C/C1=C/C[C@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)OC(=O)CCC[C@H](OC(=O)/C=C/C(C)=C/C(C)=C/C(C)=C/C[C@H](O)C[C@@H](C)O)[C@@H](C)C1,standard_macrolactone,12.0,,,success,,4.0,"[3, 6, 8, 9]",ring_size_12/standard/numbered/ML00002278_numbered.png,2026-03-19 06:54:47.777092
280,ML00010299,,,C[C@@H]1COC(=O)[C@@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
281,ML00004064,,,O=C(O)C[C@@H]1C(=O)O[C@@H]2[C@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]2[C@@H](OC(=O)c2cc(O)c(O)c4c2[C@H]1[C@H](O)C(=O)O4)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
282,ML00010328,,,CCC(=O)[C@H](C)[C@@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@@H](O)CC[C@@](C)(O)[C@@H](O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010328_numbered.png,2026-03-19 06:54:47.834721
283,ML00010984,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N[C@H](C(C)(C)C)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
284,ML00007148,,,CO[C@H]1/C=C\CC/C=C\C(=O)O[C@@H](/C(C)=C/[C@H](C)C(=O)C[C@H](O)CC2CC(=O)NC(=O)C2)[C@@H](C)C1,standard_macrolactone,12.0,,,success,,3.0,"[3, 4, 6]",ring_size_12/standard/numbered/ML00007148_numbered.png,2026-03-19 06:54:47.876311
285,ML00002064,CHEMBL3623744,,O=C(C#Cc1ccccc1)N/C=C/C[C@H]1C[C@@H](O)CC/C=C/Cc2cc(F)ccc2C(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 5]",ring_size_12/standard/numbered/ML00002064_numbered.png,2026-03-19 06:54:47.905147
286,ML00006696,,,C/C=C1\C(=O)O[C@H]2CC[N+]3(C)CC=C(COC(=O)[C@](C)(OC(C)=O)[C@H](C)[C@H]1OC(C)=O)[C@@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
287,ML00006449,,,O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(Oc5c(C(=O)O)cc(O)c(O)c5O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]2C1=CC(=O)[C@](O)(O3)C2(O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
288,ML00008165,,,C/C=C1\CC(C)C(O)C(=O)OCC2=CCN3CCC(OC1=O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
289,ML00006838,,,CC(=O)O[C@H]1/C=C\[C@H](C)[C@H](/C=C/[C@H](C)C/C=C/[C@@H](C)O)OC(=O)C[C@H](O)CC[C@]1(C)O,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00006838_numbered.png,2026-03-19 06:54:47.971059
290,ML00008200,,,C[C@H]1CC[C@H](O)[C@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 6, 7, 9]",ring_size_12/standard/numbered/ML00008200_numbered.png,2026-03-19 06:54:48.004777
291,ML00000748,CHEMBL1242564,PLA D,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@](C)(O)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)CC[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00000748_numbered.png,2026-03-19 06:54:48.046346
292,ML00001824,CHEMBL2407403,,C[C@H]1CCC/C=C/[C@H]2CC[C@H](O)[C@@H](CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
293,ML00004058,,,O=C1O[C@@H]2[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](OC(=O)c3cc(O)c(O)c(O)c3)O[C@H](COC(=O)c3cc(O)c(O)c4c3[C@H]3C1=CC(=O)[C@@](O)(O4)C3(O)O)[C@H]2OC(=O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
294,ML00010846,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010846_numbered.png,2026-03-19 06:54:48.106749
295,ML00008645,,,C/C=C1\C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
296,ML00008481,,,C/C=C1\C[C@H](C)[C@@](C)(OC(C)=O)C(=O)OCc2ccn3c2[C@@H](CC3=O)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
297,ML00007869,,,C=C1C[C@@]2(O[C@H]2C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
298,ML00007035,,,C=C1NC(=O)[C@@H](CCCc2ccc(O)cc2)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C)NC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
299,ML00008445,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)NCCOC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
300,ML00010482,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)/C=C\[C@@](C)(O)[C@H](OC(C)=O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010482_numbered.png,2026-03-19 06:54:48.183720
301,ML00007377,,,CC[C@H]1O[C@H]1[C@H](O)[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00007377_numbered.png,2026-03-19 06:54:48.227958
302,ML00009168,,,CCC[C@H](O)[C@@H](C)C(=O)NC/C=C\C[C@@H](C)[C@@H](O)[C@H](C)[C@@H]1C/C=C\C[C@H](C)[C@H](O)Cc2cc(OC)cc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 8, 9]",ring_size_12/standard/numbered/ML00009168_numbered.png,2026-03-19 06:54:48.260155
303,ML00010279,,,CC(O)CCCCC(C)C1CC(O)C(C)C(=O)N[C@H](Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
304,ML00006414,,,O=C(O[C@H]1[C@@H]2OC(=O)[C@]34CC(=O)[C@](O)(O[C@@]35C(=O)O[C@@H]3[C@H](O)CO[C@]35O)[C@]3(O)Oc5c(O)c(O)cc(c5[C@H]43)C(=O)O[C@H]1[C@H]1OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC[C@H]2O1)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
305,ML00010292,,,C[C@H]1COC(=O)[C@@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
306,ML00008765,,,C[C@@H]1[C@@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC(=O)[C@@]1(C)O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
307,ML00009153,,,O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(Oc4c(C(=O)O)cc(O)c(O)c4O)c(O)c3O)C(=O)O[C@H]([C@@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
308,ML00010235,,,CC[C@H](O)[C@](C)(O)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010235_numbered.png,2026-03-19 06:54:48.343892
309,ML00008518,,,O=C(C[C@H]1C/C=C\CCC(=O)O[C@@H](c2ccccc2)CNC1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
310,ML00008019,,,C[C@H]1CCC/C=C/C(=O)c2c(O)c(Cl)c(O)c(Cl)c2CC(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00008019_numbered.png,2026-03-19 06:54:48.377969
311,ML00006976,,,COC(=O)[C@@H]1CSCc2cccc(C)c2C(=O)OCC(NC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
312,ML00007271,,,Cc1c(O)cc(O)c2c1C(=O)OCC(NC(=O)[C@@H]1C(O)CCC1C(=O)[C@@H](N)CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)O)CSC2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
313,ML00002637,,,CC[C@H]1CCCC(O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002637_numbered.png,2026-03-19 06:54:48.432939
314,ML00006651,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00006651_numbered.png,2026-03-19 06:54:48.481530
315,ML00007536,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)O,standard_macrolactone,12.0,,,success,,8.0,"[3, 4, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007536_numbered.png,2026-03-19 06:54:48.534566
316,ML00010840,,,CCC(O)C(C)C1OC1CC(C)(O)/C=C/C=C(/C)C1OC(=O)CC(O)CCC(C)(O)C(OC(C)=O)/C=C\C1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010840_numbered.png,2026-03-19 06:54:48.577795
317,ML00008060,,,C[C@@H]1CCCCC[C@H](O)[C@H](O)/C=C\C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 9, 10]",ring_size_12/standard/numbered/ML00008060_numbered.png,2026-03-19 06:54:48.609199
318,ML00010538,,,CO[C@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@H](C)O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1ccc(Cl)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
319,ML00010683,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
320,ML00007072,,,C=C1NC(=O)[C@@H](CCCc2ccccc2)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C)NC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
321,ML00008714,,,C[C@H]1CCC[C@@H]2SC[C@](O)(C(=O)O)[C@H]2C(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00008714_numbered.png,2026-03-19 06:54:48.660475
322,ML00008049,,,C[C@@H]1CCC[C@H](O)C/C=C\[C@@H](O)CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 11]",ring_size_12/standard/numbered/ML00008049_numbered.png,2026-03-19 06:54:48.691447
323,ML00000895,CHEMBL1240973,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(=O)NCCOCCOCCNC(=O)CCCCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)CC[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00000895_numbered.png,2026-03-19 06:54:48.740567
324,ML00008741,,,CCCCCCC[C@H]1/C=C\CCCCCCCC(=O)O1,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00008741_numbered.png,2026-03-19 06:54:48.765351
325,ML00009666,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
326,ML00004016,,,O=C1O[C@@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@@H](O3)[C@@H](OC(=O)c3cc(O)c(O)c4c3[C@H]3C1=CC(=O)[C@@](O)(O4)C3(O)O)[C@H]2OC(=O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
327,ML00008112,,,CO[C@@H]1CC(=O)/C=C\C[C@@H](C)OC(=O)C[C@H](O)C1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 9, 11]",ring_size_12/standard/numbered/ML00008112_numbered.png,2026-03-19 06:54:48.830770
328,ML00001204,CHEMBL1728519,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N[C@H](C(C)(C)C)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
329,ML00009499,,,O=C1N[C@@H](Cc2c[nH]c3ccccc23)COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
330,ML00004066,,,O=C(O)C[C@@H]1C(=O)O[C@H]2[C@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]2[C@@H](OC(=O)c2cc(O)c(O)c4c2[C@@H]1[C@H](O)C(=O)O4)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
331,ML00010327,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)/C=C\[C@@](C)(O)[C@H](O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010327_numbered.png,2026-03-19 06:54:48.902927
332,ML00008071,,,C[C@@H]1C/C=C\[C@@H](O)C/C=C\[C@@H](O)CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 11]",ring_size_12/standard/numbered/ML00008071_numbered.png,2026-03-19 06:54:48.933451
333,ML00007460,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)NC[C@@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
334,ML00003885,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@](C)(O)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(=O)N2CCN(C3CCCCCC3)CC2)/C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00003885_numbered.png,2026-03-19 06:54:48.982711
335,ML00007476,,,C/C(=C/C(C)C(=O)CC(O)CC1CC(=O)NC(=O)C1)C1OC(=O)/C=C\CC/C=C\C=C/C1C,standard_macrolactone,12.0,,,success,,2.0,"[3, 4]",ring_size_12/standard/numbered/ML00007476_numbered.png,2026-03-19 06:54:49.015934
336,ML00008460,,,C/C=C1/C[C@@H](C)[C@@](C)(OC(C)=O)C(=O)OC[C@H]2[C@H](O)C[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
337,ML00007485,,,COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OCC(NC(=O)[C@@H]2C(O)CCN2C(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
338,ML00003239,,,C=C1C[C@@]23OC(=O)C/C=C\[C@H]4[C@H]5[C@H](/C=C/CC)[C@H]5[C@H](c5ccc(OC)c(OC)c5)[C@@H]4C(=O)OC[C@]2(C)[C@H]3[C@@H]2C=C(CO)C[C@@H]3C(=O)C(C)=C[C@H]3[C@@]12O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
339,ML00010784,,,CC[C@H](O)[C@H](C)[C@H](O)[C@H](O)C[C@H](C)CC/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010784_numbered.png,2026-03-19 06:54:49.091839
340,ML00007949,,,C=C1C/C(=C\C)C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
341,ML00001689,CHEMBL2152381,,O=C(C[C@@H]1C/C=C/CCC(=O)N[C@H](c2ccc(Cl)cn2)COC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
342,ML00009398,,,COc1cc2cc(c1Cl)N1CC(=O)[C@](C)(O)C(=O)N(C)[C@H](C)C(=O)O[C@@H](CC1=O)[C@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C\C=C(\C)[C@H]2OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
343,ML00007803,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@@H](C)C[C@@H](C)C(=O)/C=C/[C@H]1C,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007803_numbered.png,2026-03-19 06:54:49.162529
344,ML00008079,,,C[C@@H]1C/C=C\C(=O)C/C=C\[C@@H](O)CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 11]",ring_size_12/standard/numbered/ML00008079_numbered.png,2026-03-19 06:54:49.191278
345,ML00007147,,,CO[C@H]1/C=C\CC/C=C\C(=O)O[C@@H](/C(C)=C/[C@H](C)C(=O)CCCC2CC(=O)NC(=O)C2)[C@@H](C)[C@@H]1O,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 5, 6]",ring_size_12/standard/numbered/ML00007147_numbered.png,2026-03-19 06:54:49.225446
346,ML00001900,CHEMBL1593232,,CO[C@H]1COC(=O)[C@@H](C)COC(=O)[C@@H](OCc2ccccc2)/C=C\[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
347,ML00006754,,,CN[C@H]1C[C@H](C)O[C@H](O[C@H]2[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@@H](C)[C@@H]([C@@H](C)O)OC(=O)[C@@H]2C)[C@@H]1O,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00006754_numbered.png,2026-03-19 06:54:49.275871
348,ML00004063,,,O=C(O)/C=C1/C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1[C@@H](O)C(=O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
349,ML00006879,,,CC(=O)O[C@@]1(C)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC(=O)[C@@](O)([C@@H](C)Cl)C[C@H]1C)[C@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
350,ML00002277,,,C/C1=C/C[C@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)OC(=O)CCC[C@H](OC(=O)/C=C/C(C)=C/C(C)=C/C(C)=C/C[C@@H](O)C[C@H](C)O)[C@@H](C)C1,standard_macrolactone,12.0,,,success,,4.0,"[3, 6, 8, 9]",ring_size_12/standard/numbered/ML00002277_numbered.png,2026-03-19 06:54:49.325502
351,ML00009874,,,COc1cc2cc(c1Cl)N1CC(O)C(C)(O)C(=O)NC(C)C(=O)O[C@@H](CC1=O)[C@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C/C=C(\C)C2OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
352,ML00001747,CHEMBL2152361,,C[C@H]1C/C=C/C[C@@H](CC(=O)NCc2ccc(Cl)cc2)C(=O)OC[C@@H](c2ccccc2)NC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
353,ML00008593,,,C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
354,ML00010106,,,CCC(=O)[C@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)/C=C\[C@@](C)(O)[C@H](OC(C)=O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010106_numbered.png,2026-03-19 06:54:49.387353
355,ML00007475,,,C/C(=C\[C@H](C)C(=O)/C=C/CC1CC(=O)NC(=O)C1)[C@H]1OC(=O)/C=C\CC/C=C\[C@H](O)[C@@H](O)[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 5, 6]",ring_size_12/standard/numbered/ML00007475_numbered.png,2026-03-19 06:54:49.420651
356,ML00010803,,,O=C1OC[C@H]2CCCN2C(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@H]1Cc1ccc(F)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
357,ML00007167,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NCCOC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
358,ML00002102,CHEMBL2420697,,CC[C@H](OC)[C@@H](C)[C@H]1O[C@@H]1[C@@H](O)[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00002102_numbered.png,2026-03-19 06:54:49.474208
359,ML00006603,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)N2CCC[C@@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
360,ML00009157,,,O=C(OC1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC(C1O)C2OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
361,ML00007527,,,CC1CC(N(C)C)C(O)C(OC2C(C)CC(C)C(=O)/C=C/C(C)C(C(C)O)OC(=O)C2C)O1,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007527_numbered.png,2026-03-19 06:54:49.530988
362,ML00008650,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3([O-])CC[C@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
363,ML00008656,,,C=C1C/C(=C/C)C(=O)O[C@@H]2CCN3C[C@@H](O)[C@H](COC(=O)[C@@]1(C)O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
364,ML00000093,CHEMBL2418196,DEMETHOXYDEBROMOAPLYSIATOXIN,C[C@@H](CCCc1cccc(O)c1)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@@H](C)O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
365,ML00001774,CHEMBL2152357,,O=C(C[C@@H]1C/C=C/CCC(=O)N[C@H](c2ccccc2)COC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
366,ML00008928,,,O=C1N[C@@H](Cc2ccccc2)COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
367,ML00003052,,,CO[C@@H]1[C@@H](OC[C@H](C)[C@H]2OC(=O)[C@H](C)[C@@H](O[C@@H]3C[C@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](C)[C@H]3O[C@@](O)([C@H](C)[C@@H](OC(=O)[C@H](O)C(C)C)[C@H]2C)[C@@](C)(O)C[C@@H]3C)O[C@@H](C)[C@@H](O)[C@@H]1OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
368,ML00003939,,,O=C(O[C@@H]1O[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]3[C@@H]2OC(=O)c2cc(O)c(O)c4oc5c(O)c(O)cc(c5c24)C(=O)O[C@@H]13)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
369,ML00007165,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NCCOC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
370,ML00003372,,,O=C(N[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=O)OCC1c2ccccc2-c2ccccc21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
371,ML00007096,,,C[C@@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
372,ML00008425,,,C/C=C1\C[C@@H](C)[C@@](C)(OC(C)=O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
373,ML00006868,,,CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@](O)([C@H](C)Cl)C[C@H]1C)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
374,ML00010073,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
375,ML00007023,,,C[C@H]1CCCCCC(=O)c2c(cc(O)cc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)CC(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00007023_numbered.png,2026-03-19 06:54:49.649136
376,ML00004041,,,O=C1C=C2C(=O)O[C@H]3[C@@H]4OC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)OC[C@H]3O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]4OC(=O)c3cc(O)c(O)c(O)c3[C@@H]2C(=O)C1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
377,ML00004027,,,O=C1O[C@H]2[C@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H](OC(=O)c3cc(O)c(O)c4c3[C@@H]3C1=CC(=O)C(O)(O)[C@]3(O)O4)[C@@H]1OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC[C@H]2O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
378,ML00008495,,,O=C1OC[C@H]2O[C@H](O)[C@H](O)[C@@H](OC(=O)c3cc(O)c(O)c(O)c3-c3c1cc(O)c(O)c3O)[C@@H]2O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
379,ML00009152,,,O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(Oc4c(C(=O)O)cc(O)c(O)c4O)c3O)C(=O)O[C@H]([C@@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
380,ML00008160,,,CO[C@H]1CCC[C@@H](C)OC(=O)c2c(O)cc(O)cc2CC(=O)C1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 9]",ring_size_12/standard/numbered/ML00008160_numbered.png,2026-03-19 06:54:49.713119
381,ML00001722,CHEMBL288741,,CCCC[C@H]1OC(=O)C[C@H](O)[C@H](Cc2ccccc2)N(C)C(=O)COC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
382,ML00009179,,,CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](C)(O)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
383,ML00009135,,,O=C(Oc1c(O)cc2c(c1O)-c1c(cc(O)c(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](O)[C@@H](OC2=O)[C@@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
384,ML00007544,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007544_numbered.png,2026-03-19 06:54:49.776700
385,ML00010515,,,C=C[C@H]1[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OCC[C@@H]3C(=CO[C@@H](O[C@H]4O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]4O)[C@@H]3C=C)C(=O)OCC[C@H]21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
386,ML00007379,,,CC(=O)O[C@H]1/C=C\[C@H](C)[C@H](/C(C)=C/C=C/[C@H](C)C[C@H]2O[C@H]2[C@H](C)O)OC(=O)C[C@H](O)CC[C@]1(C)O,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00007379_numbered.png,2026-03-19 06:54:49.824386
387,ML00007173,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)N[C@H](Cc2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
388,ML00007429,,,CC(C)[C@@H]1OC(=O)[C@H](C)[C@H](O)[C@H](Cc2cccnc2)NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
389,ML00001830,CHEMBL1077980,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\OC2=O,standard_macrolactone,12.0,,,success,,3.0,"[5, 6, 7]",ring_size_12/standard/numbered/ML00001830_numbered.png,2026-03-19 06:54:49.867743
390,ML00009902,,,CC/C=C/[C@H]1CCC[C@H](O)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@H]4C(C)=C[C@H]3[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00009902_numbered.png,2026-03-19 06:54:49.900922
391,ML00008197,,,C[C@H]1CCC[C@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 9]",ring_size_12/standard/numbered/ML00008197_numbered.png,2026-03-19 06:54:49.930476
392,ML00006657,,,C[C@@H]1CCCCCCCc2cc(OCc3ccccc3)cc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00006657_numbered.png,2026-03-19 06:54:49.952786
393,ML00010143,,,O=C(N[C@H]1COC(=O)[C@@H](NC(=O)c2cccc(O)c2O)COC(=O)[C@H](NC(=O)c2cccc(O)c2O)COC1=O)c1cccc(O)c1O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
394,ML00009930,,,CO[C@@H]1/C=C(\C)C[C@@H](/C=C/C=C/Br)OC(=O)[C@@H](C)[C@]2(O)C[C@@H](O[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]3OC)[C@H](C)[C@@H](C1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
395,ML00008317,,,C/C=C1/C[C@H](C)[C@@](C)(CO)C(=O)OC[C@H]2CCN3CC[C@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
396,ML00008418,,,C/C=C1/C[C@H](C)[C@](O)(CO)C(=O)OCC2=CC(=O)N3CC[C@H](OC1=O)[C@@]23OCC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
397,ML00010429,,,C[C@H]1COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
398,ML00008647,,,C[C@@H]1O[C@@]12C[C@@H](C)[C@@](C)(O)C(=O)OC/C1=C/CNCC[C@@H](OC2=O)C1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
399,ML00010774,,,CCCCCCCCC[C@]1(CO)CCCC(=O)O[C@](CO)(CCCCCCCCC)CCCC(=O)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
400,ML00009154,,,O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]([C@@H]2O)[C@H]1OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
401,ML00007831,,,C[C@H](O)[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007831_numbered.png,2026-03-19 06:54:50.046924
402,ML00001170,CHEMBL40037,,CCCCCCC[C@H]1OC(=O)C[C@H](OCOC)[C@H](Cc2ccccc2)N(C)C(=O)C(C)(C)OC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
403,ML00006872,,,C=C[C@]1(C(C)=O)C(=O)O[C@@H]2CC[N+]3(C)CC=C(COC(=O)[C@@](C)(O)[C@@H](C)[C@H]1O)[C@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
404,ML00008467,,,C/C=C1\C[C@@H](C)[C@@](C)(OC(C)=O)C(=O)OCc2ccn3c2[C@H](CC3=O)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
405,ML00007303,,,O=C1NCCOC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
406,ML00008324,,,C[C@@H]1C[C@]2(C)CC(=O)O[C@@H]3CC[N+]4(CCl)CC=C(COC(=O)[C@@]1(C)O2)[C@H]34,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
407,ML00001825,CHEMBL2407404,,C[C@H]1CCC/C=C/[C@H]2CC[C@H](O)[C@H](CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
408,ML00008610,,,C/C=C1\C[C@H](C)[C@@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
409,ML00007356,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)CCCCCC/C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,2.0,"[3, 4]",ring_size_12/standard/numbered/ML00007356_numbered.png,2026-03-19 06:54:50.118017
410,ML00010079,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
411,ML00006677,,,CO/N=C/C=C\C(=O)NC/C=C/[C@@H]1OC(=O)c2c(O)cccc2/C=C\C=C/C=C\[C@@H]1O,standard_macrolactone,12.0,,,success,,2.0,"[3, 4]",ring_size_12/standard/numbered/ML00006677_numbered.png,2026-03-19 06:54:50.151641
412,ML00005027,,,O=C(O[C@H]1[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC[C@@H]2O[C@@H]1OC(=O)c1cc(O)c(O)c(O)c1Oc1cc2c(c(O)c1O)-c1c(cc(O)c(O)c1O)C(=O)O[C@H]1[C@@H](O)[C@H](COC2=O)O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
413,ML00007951,,,C=C1C/C(=C\C)C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
414,ML00008059,,,C[C@@H]1CCCCC[C@H](O)[C@@H](O)/C=C\C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 9, 10]",ring_size_12/standard/numbered/ML00008059_numbered.png,2026-03-19 06:54:50.198776
415,ML00009875,,,COc1cc2cc(c1Cl)N1CC[C@](C)(O)C(=O)N[C@@H](C)C(=O)O[C@H](CC1=O)[C@@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C\C=C(\C)[C@@H]2OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
416,ML00008188,,,C[C@H]1CCC[C@@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 9]",ring_size_12/standard/numbered/ML00008188_numbered.png,2026-03-19 06:54:50.236526
417,ML00011002,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N[C@H](C(C)(C)C)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
418,ML00010311,,,CC[C@H](OC)[C@@H](C)[C@H]1O[C@@H]1[C@@H](O)[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)CCCCCC/C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,2.0,"[3, 4]",ring_size_12/standard/numbered/ML00010311_numbered.png,2026-03-19 06:54:50.271125
419,ML00004012,,,O=C1O[C@@H]2[C@H](OC(=O)c3cc(O)c(O)c(O)c3)O[C@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@@H]2[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]2C1=CC(=O)[C@](O)(O3)C2(O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
420,ML00008056,,,C[C@@H]1CCC[C@@H](O)C/C=C\[C@@H](O)CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 11]",ring_size_12/standard/numbered/ML00008056_numbered.png,2026-03-19 06:54:50.309822
421,ML00007275,,,CCC(C)C1OC(=O)C(NC(=O)c2cccc(NC=O)c2O)C(C)OC(=O)C(C)C(=O)C(CC(C)C)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
422,ML00009503,,,COC(=O)Cc1c(C(=O)O[C@H]2[C@H](OC(=O)c3cc(O)c(O)c(O)c3)O[C@@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]2[C@@H]3O)cc(O)c(O)c1O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
423,ML00010798,,,O=C(C[C@@H]1C/C=C\C[C@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
424,ML00007840,,,C/C=C1/C[C@]2(CO)O[C@@]2(C)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
425,ML00007790,,,COc1cc(O)cc2c1C(=O)O[C@@H](C)C[C@H](O)CCCCC2,standard_macrolactone,12.0,,,success,,2.0,"[3, 5]",ring_size_12/standard/numbered/ML00007790_numbered.png,2026-03-19 06:54:50.362050
426,ML00004065,,,O=C(O)C[C@@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1[C@@H](O)C(=O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
427,ML00008027,,,C[C@@H]1CCC/C=C\C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00008027_numbered.png,2026-03-19 06:54:50.398235
428,ML00001638,CHEMBL4073900,,CCCCCC/C=C\CC(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CO)[C@@H](O)CC(=O)N[C@H](C(=O)N[C@@H]1/C=C/C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)OC1)C(C)C)C(C)C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
429,ML00001937,CHEMBL1484157,,CC(C)(C)[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
430,ML00003324,,,C[C@H]1OC(=O)[C@@H](NC(=O)CNC(=O)c2cccc(O)c2O)[C@@H](C)OC(=O)[C@@H](NC(=O)CNC(=O)c2cccc(O)c2O)[C@@H](C)OC(=O)[C@H]1NC(=O)CNC(=O)c1cccc(O)c1O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
431,ML00010800,,,O=C(C[C@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
432,ML00009155,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@H]1OC(=O)c1cc(O)c(O)c(O)c1)[C@@H]2O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
433,ML00003597,,,C=C(C#N)CO[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]3[C@@H]2OC(=O)C2=CC(=O)[C@]4(O)Oc5c(O)c(O)cc(c5[C@H]2C4(O)O)C(=O)O[C@H]31,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
434,ML00008280,,,C=C1C[C@H](CC)C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@@]1(C)O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
435,ML00006798,,,COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OCC(NC(=O)[C@@H](CO)NC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
436,ML00008013,,,C[C@H]1CCC/C=C\C(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00008013_numbered.png,2026-03-19 06:54:50.490933
437,ML00006719,,,CN1CCN(C(=O)C[C@@H]2C/C=C/CCC(=O)O[C@H](c3ccccc3)CNC2=O)CC1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
438,ML00009148,,,O=C(O[C@H]([C@@H](OC(=O)c1cc(O)c(O)c(O)c1)C(=O)O)[C@@H]1OC(=O)c2cc(O)c(O)c(O)c2-c2cc(c(O)c(O)c2O)C(=O)OC[C@@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
439,ML00002472,,,CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](C)(O[C@@H]4O[C@@H](C)[C@@H](O)[C@@](C)(O)[C@H]4OC)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
440,ML00001124,CHEMBL1699081,,O=C1N[C@@H](c2ccccc2)COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
441,ML00008652,,,C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3([O-])CC[C@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
442,ML00008286,,,C/C=C1\CC(C)C(C)(O)C(=O)OC/C2=C/CN(C)CCC(OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
443,ML00008622,,,C[C@H]1O[C@@]12C[C@@H](C)[C@@](C)(O)C(=O)OCC1=CCN3CC[C@@H](OC2=O)[C@@H]13,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
444,ML00007862,,,C/C=C1\C[C@]2(CO2)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
445,ML00010490,,,CC(C)(C)[C@@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
446,ML00008167,,,C/C=C1\C[C@@H](C)[C@@H](O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
447,ML00007483,,,Cc1c(O)cc(O)c2c1C(=O)OC[C@H](NC(=O)[C@@H]1[C@H](O)CCN1C(=O)[C@@H](N)CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)O)CSC2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
448,ML00008169,,,COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OCCC(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
449,ML00008615,,,C/C=C1/C[C@H](C)[C@@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
450,ML00003371,,,O=C(C[C@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
451,ML00003129,,,C/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C(C(=O)OC)[C@H]1CC(=O)O[C@H]1C[C@H](C)[C@H]2COC(=O)C[C@@H]3C(=CO[C@@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)/C3=C/C)C(=O)OC[C@H](C)[C@H]12,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
452,ML00007886,,,C[C@@H]1C[C@]2(C)CC(=O)O[C@@H]3CCN4CC=C(COC(=O)[C@@]1(C)O2)[C@H]34,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
453,ML00010665,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](c2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
454,ML00007293,,,CC(C)N[C@H]1C/C=C/C[C@@H](CC(=O)NCc2ccc(Cl)cc2)C(=O)NC[C@@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
455,ML00008070,,,C[C@@H]1CCCCC[C@H](O)C(=O)/C=C\C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 9, 10]",ring_size_12/standard/numbered/ML00008070_numbered.png,2026-03-19 06:54:50.658197
456,ML00002808,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](C6CCC6)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002808_numbered.png,2026-03-19 06:54:50.695834
457,ML00004031,,,O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]2C1=CC(=O)[C@@H](O3)C2(O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
458,ML00004061,,,O=C(O)C[C@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]1[C@H](O)C(=O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
459,ML00006794,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N[C@H](C(C)(C)C)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
460,ML00000982,CHEMBL2381164,,CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4c(Br)cc(Br)c(O)c4Br)O[C@@]1(C3)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
461,ML00006111,,,CCCCCC/C=C\CC(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CO)[C@@H](O)CC(=O)N[C@H](C(=O)N[C@@H]1/C=C\C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)OC1)C(C)C)C(C)C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
462,ML00007478,,,C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,2.0,"[3, 4]",ring_size_12/standard/numbered/ML00007478_numbered.png,2026-03-19 06:54:50.766825
463,ML00010630,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
464,ML00006980,,,C=C/C1=C/[C@@H](C)[C@](C)(OC(C)=O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
465,ML00008462,,,CC[C@@]1(O)C[C@@H](C)[C@](C)(OC(C)=O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
466,ML00008272,,,C[C@@H]1C[C@@]2(O[C@@H]2C)C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@@]1(C)O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
467,ML00009053,,,CO[C@@H]1[C@H](O[C@H]2C[C@@]3(O)CC(=O)O[C@@H](/C=C/C=C/C#C[C@H]4C[C@@H]4Cl)C/C(C)=C\[C@@H](OC)[C@@H](C)[C@H](O3)[C@@H]2C)O[C@H](C)[C@H](NC=O)[C@]1(C)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
468,ML00007884,,,C[C@@H]1C[C@@]2(C)CC(=O)O[C@@H]3CCN4CC=C(COC(=O)[C@]1(C)O2)[C@H]34,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
469,ML00007337,,,CC[C@H](C)[C@H]1OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC(=O)C(C)(C)C(=O)[C@@H](CC(C)C)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
470,ML00008384,,,CC1CCCC(SCC(O)C(=O)O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 9]",ring_size_12/standard/numbered/ML00008384_numbered.png,2026-03-19 06:54:50.850304
471,ML00007914,,,C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OCc2ccn3c2[C@H](CC3=O)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
472,ML00004045,,,O=C1C=C2C(=O)O[C@H]3[C@@H]4OC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)OC[C@H]3O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]4OC(=O)c3cc(O)c(O)c(O)c3[C@H]2[C@@H](C(=O)O)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
473,ML00006697,,,CO[C@@H]1[C@@H](CO)O[C@@H](Oc2cc(O)cc3c2C(=O)CCCCC[C@H](C)OC(=O)C3)[C@H](O)[C@H]1O,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00006697_numbered.png,2026-03-19 06:54:50.895612
474,ML00007633,,,CCC(C)C1OC(=O)[C@@H](NC(=O)c2cccc(N)c2O)[C@H](C)OC(=O)C(C)(C)OC(CC(C)C)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
475,ML00008639,,,C=C1C/C(=C/C)C(=O)O[C@@H]2CCN3C[C@@H](O)[C@H](COC(=O)[C@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
476,ML00010098,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
477,ML00010833,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010833_numbered.png,2026-03-19 06:54:50.962929
478,ML00007996,,,C[C@H]1CCC/C=C\[C@H]2CC[C@H](O)[C@H](CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
479,ML00008075,,,C[C@@H]1CCCCCCC(=O)/C=C\C(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 10]",ring_size_12/standard/numbered/ML00008075_numbered.png,2026-03-19 06:54:50.994739
480,ML00008598,,,C/C=C1\C[C@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
481,ML00010492,,,CC(C)(C)[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
482,ML00008660,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3C[C@@H](O)[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
483,ML00007916,,,CSC1=NC2c3ccccc3SCCCCCOC(=O)C2C(C)=N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
484,ML00005754,,,CC(=C/C(C)=C/C=C/C(C)=C/[C@H](O)[C@H](O)C[C@H](C)O)/C=C/C(=O)O[C@H]1CCCC(=O)O[C@H]([C@@H](C)C/C(C)=C/[C@H](C)[C@@H](O)C[C@H](C)O)C/C=C(/C)C[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 6, 8, 9]",ring_size_12/standard/numbered/ML00005754_numbered.png,2026-03-19 06:54:51.059888
485,ML00006781,,,CC(C)C[C@@H]1NC(=O)C[C@H]2[C@@H]3OC(C)(C)O[C@H]3c3cc4c(cc3N2C/C=C\COC1=O)OCO4,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
486,ML00008515,,,COC(=O)[C@@H]1CSCc2c(O)cc(O)cc2C(=O)OCC(NC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
487,ML00008489,,,C=C1C/C(=C/C)C(=O)O[C@@H]2CC(=O)n3ccc(c32)COC(=O)[C@@]1(C)OC(C)=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
488,ML00004032,,,O=C(O[C@@H]1COC(=O)c2cc(c(O)c(O)c2O)-c2c(cc(O)c(O)c2O)C(=O)O[C@H]1[C@@H]1OC(=O)c2cc(O)c(O)c(O)c2-c2c(O)c(O)c(O)c3c2C(=O)O[C@@H]1[C@H]3O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
489,ML00001176,CHEMBL3259831,,C/C=C\c1nc(CC/C=C\C(=O)O[C@@H]2C[C@H]3/C=C(/C)C[C@H](OC)C[C@H](CCC)OC(=O)C[C@@H](C2)O3)co1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
490,ML00004022,,,O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]2C1=CC(=O)C(O)(O)[C@]2(O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
491,ML00008661,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3C[C@H](O)[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
492,ML00001060,CHEMBL1078175,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C(F)=C/OC2=O,standard_macrolactone,12.0,,,success,,4.0,"[4, 5, 6, 7]",ring_size_12/standard/numbered/ML00001060_numbered.png,2026-03-19 06:54:51.148279
493,ML00001704,CHEMBL2152370,,O=C(C[C@@H]1C/C=C/CCC(=O)O[C@H](c2ccccc2)CNC1=O)NCCCC(F)(F)F,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
494,ML00008193,,,C[C@@H]1CCC[C@@H](O)CC(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 9]",ring_size_12/standard/numbered/ML00008193_numbered.png,2026-03-19 06:54:51.183700
495,ML00000108,CHEMBL2148107,,C[C@@H]1CC(C)(C)[C@@]23C[C@@H](C[C@@H](CCCCc4cccc(O)c4)O2)OC(=O)C[C@H](CO)OC(=O)C[C@@H]1O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
496,ML00007406,,,C[C@H]1C/C=C/Cc2cccc(O)c2C(=O)O[C@@H](C/C=C/NC(=O)C#Cc2ccccc2)C[C@H]1O,standard_macrolactone,12.0,,,success,,3.0,"[3, 5, 6]",ring_size_12/standard/numbered/ML00007406_numbered.png,2026-03-19 06:54:51.220005
497,ML00001910,CHEMBL2420608,,CC[C@H](OC)[C@@H](C)[C@H]1O[C@@H]1[C@H](OC(C)=O)[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00001910_numbered.png,2026-03-19 06:54:51.260995
498,ML00007545,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007545_numbered.png,2026-03-19 06:54:51.305107
499,ML00010416,,,C[C@H]1COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
500,ML00002793,,,CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)[C@@H](O)[C@H]4C=C[C@H]3[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002793_numbered.png,2026-03-19 06:54:51.346900
501,ML00007858,,,C=C1C/C(=C/C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@@]1(O)CO)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
502,ML00008078,,,C[C@@H]1OC(=O)/C=C\[C@H](O)[C@H](C)OC(=O)/C=C\[C@@H]1O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
503,ML00008354,,,COc1cc(O)c2c(c1C)C(=O)O[C@H](CO)C/C(S)=N/[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
504,ML00009136,,,O=C1NC[C@@H](c2ccccc2)OC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
505,ML00007950,,,C=C1C/C(=C\C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
506,ML00006888,,,C/C=C1\C[C@@H](C)[C@](C)(OC(C)=O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
507,ML00004044,,,O=C1C[C@H]2C(=O)O[C@H]3[C@@H]4OC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)OC[C@H]3O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]4OC(=O)c3cc(O)c(O)c(O)c3C2=C(C(=O)O)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
508,ML00004068,,,O=C(O)CC1C(=O)OC2C3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC2C(OC(=O)c2cc(O)c(O)c4c2C1C(O)C(=O)O4)C(OC(=O)c1cc(O)c(O)c(O)c1)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
509,ML00001745,CHEMBL2152355,,C[C@H]1NC(=O)[C@H](CC(=O)NCc2ccc(Cl)cc2)C/C=C/CCC(=O)O[C@@H]1c1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
510,ML00004291,,,CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H](O[C@@H]4O[C@@H](C)[C@H](O)[C@@](C)(O)[C@H]4O)[C@@](C)(O)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
511,ML00003373,,,O=C(N[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@@H]2COC1=O)OCC1c2ccccc2-c2ccccc21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
512,ML00009104,,,O=C1O[C@H]2[C@H](O)[C@@H](OC(=O)c3cc(O)c(O)c4c3[C@@H]3C1=CC(=O)[C@](O)(O4)C3(O)O)[C@@H]1OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC[C@H]2O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
513,ML00007164,,,CC[C@H](C)[C@H]1OC(=O)[C@@H](NC(=O)c2cccc(N)c2O)[C@@H](C)OC(=O)C(C)(C)C(=O)[C@@H](CC(C)C)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
514,ML00010698,,,CC/C=C/C=C/CC[C@]1(C)C[C@H](O)[C@H](C)CC[C@H]2C[C@@H](C[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]3OC)C[C@@](O)(CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
515,ML00007887,,,C=C1C/C(=C\C)C(=O)O[C@@H]2CCN3CC[C@H](COC(=O)[C@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
516,ML00001746,CHEMBL2152354,,C[C@@H]1NC(=O)[C@H](CC(=O)NCc2ccc(Cl)cc2)C/C=C/CCC(=O)O[C@@H]1c1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
517,ML00010070,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
518,ML00002381,,,CCC[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002381_numbered.png,2026-03-19 06:54:51.511745
519,ML00007044,,,CCCOc1cc2c(c(OCCC)c1)C(=O)O[C@H](C)CCCCCCC2,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00007044_numbered.png,2026-03-19 06:54:51.535467
520,ML00006386,,,O=C(OC1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC3C2OC(=O)[C@@]24CC(=O)[C@@](O)(OC25C(=O)O[C@H]2[C@@H](O)CO[C@@]25O)C2(O)Oc5c(O)c(O)cc(c5C24)C(=O)OC13)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
521,ML00004029,,,O=C1OC[C@@H](O)[C@H]([C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)c4c3C(=O)O[C@@H]2[C@@H]4O)OC(=O)c2cc(O)c(O)c(O)c2-c2cc1c(O)c(Oc1c(C(=O)O)cc(O)c(O)c1O)c2O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
522,ML00003940,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]3[C@H]1OC(=O)c1cc(O)c(O)c4oc5c(O)c(O)cc(c5c14)C(=O)O[C@@H]32)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
523,ML00008050,,,C[C@H]1CCCCCC/C=C\CC(=O)O1,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00008050_numbered.png,2026-03-19 06:54:51.587907
524,ML00008318,,,C[C@@H]1C[C@](O)([C@@H](C)Cl)C(=O)O[C@@H]2CC[N+]3(C)CC=C(COC(=O)[C@]1(C)O)[C@@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
525,ML00007435,,,CC/C=C\C=C/C(=O)N/C=C/C[C@H]1C[C@H](O)[C@H](C)C/C=C\Cc2cccc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 5, 6]",ring_size_12/standard/numbered/ML00007435_numbered.png,2026-03-19 06:54:51.627109
526,ML00010496,,,CCCCCCC[C@H]1OC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)OC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
527,ML00008556,,,COc1cc(O)cc2c1C(=O)OC(C)(C)CCCCCCC2,standard_macrolactone,12.0,,,success,,2.0,"[3, 3]",ring_size_12/standard/numbered/ML00008556_numbered.png,2026-03-19 06:54:51.661742
528,ML00008014,,,C[C@H]1CCC(=O)[C@H]2CC(=O)c3c(cc(O)cc3O2)CC(=O)O1,non_standard_macrocycle,12.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
529,ML00006943,,,COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OCC(NC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
530,ML00007637,,,C/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OC[C@H](C)[C@@H]3C[C@H](OC(=O)C[C@H]21)[C@H](C)[C@H]3CO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
531,ML00000040,CHEMBL1242745,PLADIENOLIDE B,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)CC[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00000040_numbered.png,2026-03-19 06:54:51.725203
532,ML00007594,,,O=C(C[C@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
533,ML00006820,,,O=C1CC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@H]2CO1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
534,ML00004025,,,O=C1O[C@@H]2[C@@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@@H]2[C@H](OC(=O)c2cc(O)c(O)c4c2[C@@H]2C1=CC(=O)[C@](O)(O4)C2(O)O)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
535,ML00000068,CHEMBL2148106,DEBROMOAPLYSIATOXIN,CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@@H](C)O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cccc(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
536,ML00008216,,,C[C@@H]1CC[C@@H](O)/C=C\C(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 6, 9]",ring_size_12/standard/numbered/ML00008216_numbered.png,2026-03-19 06:54:51.785208
537,ML00007611,,,CC/C(C)=C1\OC(=O)[C@H](C)[C@@H](O)[C@H](Cc2cccnc2)NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
538,ML00000644,CHEMBL2407405,,CCO[C@H]1C=C[C@H]2C/C=C\CC[C@H](C)OC(=O)C[C@@H]1O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
539,ML00002636,,,CCN[C@@H]1CC[C@@H](O[C@@H]2CCC[C@H](CC)OC(=O)C[C@@H]3C(=C[C@H]4[C@@H]3C=C[C@H]3C[C@@H](O[C@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@@H]5OC)C[C@@H]34)C(=O)[C@H]2C)O[C@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002636_numbered.png,2026-03-19 06:54:51.836919
540,ML00001729,CHEMBL290433,,COCO[C@@H]1CC(=O)O[C@H](C)[C@H](C)C(=O)O[C@@H](C(C)C)C(=O)N(C)[C@H]1Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
541,ML00007112,,,C[C@H]1COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
542,ML00008308,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CC[N+]3(C)CC[C@@H](OC1=O)[C@@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
543,ML00008596,,,C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
544,ML00008566,,,C[C@H](Cl)[C@@]1(O)C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
545,ML00010302,,,CC(=O)CCCC[C@@H](C)[C@H]1C[C@H](O)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
546,ML00008379,,,C/C=C1\C[C@H](C)[C@@H](OC(C)=O)C(=O)OCC2=CCN3CC[C@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
547,ML00007791,,,COc1cc(O)cc2c1C(=O)O[C@H](C)CC[C@@H](O)CCCC2,standard_macrolactone,12.0,,,success,,2.0,"[3, 6]",ring_size_12/standard/numbered/ML00007791_numbered.png,2026-03-19 06:54:51.912705
548,ML00010491,,,C=C[C@H]1[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OCC[C@@H]3C(=CO[C@@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H]3C=C)C(=O)OCC[C@H]21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
549,ML00004206,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@@H]1O)[C@H]2OC(=O)[C@@H]1CC(=O)c2oc(=O)c3cc(O)c(O)c(O)c3c21)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
550,ML00004018,,,O=C1OC2C(OC(=O)c3cc(O)c(O)c(O)c3)OC3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC2C3OC(=O)c2cc(O)c(O)c3c2C2C1=CC(=O)C(O)(O3)C2(O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
551,ML00006725,,,O=C(C[C@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
552,ML00004023,,,O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]2C1=CC(=O)C(O)(O)[C@]2(O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
553,ML00007842,,,C[C@@H]1OC[C@@]23C[C@]1(O)C(=O)O[C@@H]1CCN4CC=C(COC(=O)[C@@]2(C)O3)[C@H]14,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
554,ML00007795,,,COc1cc(O)cc2c1C(=O)OC(C)C(O)CCCCCC2,standard_macrolactone,12.0,,,success,,2.0,"[3, 4]",ring_size_12/standard/numbered/ML00007795_numbered.png,2026-03-19 06:54:51.990745
555,ML00006654,,,C/C=C1\C(=O)OC2CCN(C)C/C=C(/COC(=O)C(C)(OC(C)=O)C(C)C1OC(C)=O)C2O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
556,ML00007166,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NCCOC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
557,ML00008581,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2[C@H](O)CN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
558,ML00007656,,,C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\CC[C@@H]1C,standard_macrolactone,12.0,,,success,,2.0,"[3, 4]",ring_size_12/standard/numbered/ML00007656_numbered.png,2026-03-19 06:54:52.040502
559,ML00009247,,,CO[C@@H]1[C@H](O[C@H]2C[C@@]3(O)CC(=O)O[C@@H](/C=C/C=C/C#C[C@H]4C[C@@H]4Cl)C/C(C)=C\[C@@H](OC)[C@@H](C)[C@H](O3)[C@@H]2C)O[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
560,ML00007174,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)N[C@@H](Cc2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
561,ML00002400,,,CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@@H](NC)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002400_numbered.png,2026-03-19 06:54:52.093028
562,ML00009130,,,O=C1OC[C@H](c2ccccc2)NC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@H]1Cc1ccc(F)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
563,ML00008461,,,CC(=O)O[C@@]1(C)C(=O)OCC2=CCN3CC[C@@H](OC(=O)[C@@](O)([C@H](C)O)C[C@H]1C)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
564,ML00008284,,,C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
565,ML00007477,,,C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@H]1OC(=O)/C=C\CC/C=C\C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,2.0,"[3, 4]",ring_size_12/standard/numbered/ML00007477_numbered.png,2026-03-19 06:54:52.142673
566,ML00001003,CHEMBL1081556,,O=C(C[C@@H]1C/C=C/CCC(=O)O[C@@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
567,ML00008373,,,Cc1c(O)cc(O)c2c1C(=O)OCC(NC(=O)OC(C)(C)C)C(=O)NCCSC2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
568,ML00008256,,,C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
569,ML00002279,,,CC(=C/C(C)=C/C[C@H](O)C[C@@H](C)O)/C=C(C)\C=C\C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 6, 8, 9]",ring_size_12/standard/numbered/ML00002279_numbered.png,2026-03-19 06:54:52.197668
570,ML00008307,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CC[N+]3(C)CC[C@@H](OC1=O)[C@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
571,ML00007774,,,O=C(C[C@H]1C/C=C\CCC(=O)OC[C@H]2CCCN2C1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
572,ML00007094,,,C[C@@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
573,ML00010066,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N2CCC[C@@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
574,ML00008285,,,C/C=C1\C[C@H](C)[C@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
575,ML00001094,CHEMBL1242374,PLADIENOLIDE F,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@](C)(O)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](O)CC[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00001094_numbered.png,2026-03-19 06:54:52.273338
576,ML00010274,,,CC[C@H](OC)[C@@H](C)[C@H]1O[C@@H]1[C@@H](O)[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CCCC/C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,3.0,"[3, 4, 11]",ring_size_12/standard/numbered/ML00010274_numbered.png,2026-03-19 06:54:52.305997
577,ML00008288,,,C/C=C1\CC(C)C(C)(CO)C(=O)OCC2=CCN3CCC(OC1=O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
578,ML00009143,,,O=C(C[C@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)O[C@H](c2ccccc2)CNC1=O)N[C@@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
579,ML00007413,,,O=C(OC1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)CC(C2O)C1O)c1cc(O)c(O)c(O)c1,standard_macrolactone,12.0,,,success,,2.0,"[5, 8]",ring_size_12/standard/numbered/ML00007413_numbered.png,2026-03-19 06:54:52.347760
580,ML00010276,,,C[C@@H]1COC(=O)[C@@H](CC(=O)OC(C)(C)C)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
581,ML00008362,,,C=C1C/C(=C/C)C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@]1(C)O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
582,ML00010540,,,CO[C@H](CC[C@@H](C)[C@@H]1O[C@@]23C[C@@H](OC(=O)C[C@@H]([C@H](C)O)OC(=O)CC(=C(C)CC2(C)C)O3)[C@H]1C)c1cccc(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
583,ML00008263,,,C/C=C1/C[C@@H](C)[C@](O)(CO)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
584,ML00002882,,,CCCCCC/C=C\CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H]1/C=C\C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)OC1)C(C)C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
585,ML00007888,,,C/C=C1\CC(C)C(C)(O)C(=O)OCC2=CCN3CCC(OC1=O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
586,ML00004075,,,O=C1OC[C@H]2O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]3OC(=O)c4cc(O)c(O)c5c4[C@@H]4C(=CC(=O)[C@](O)(O5)C4(O)O)C(=O)O[C@H]2[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]2C1=CC(=O)[C@](O)(O3)C2(O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
587,ML00000027,CHEMBL1258348,,CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4cccc(O)c4)O[C@@]1(C3)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
588,ML00000072,CHEMBL1256416,APLYSIATOXIN,CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@@H](C)O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cc(O)ccc1Br,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
589,ML00004015,,,O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@@H](O3)[C@@H](OC(=O)c3cc(O)c(O)c4c3[C@H]3C1=CC(=O)[C@@](O)(O4)C3(O)O)[C@@H]2OC(=O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
590,ML00007426,,,CC/C=C\C=C/C(=O)N/C=C/C[C@H]1C[C@@H](O)[C@@H](C)C/C=C/Cc2ccc(F)c(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 5, 6]",ring_size_12/standard/numbered/ML00007426_numbered.png,2026-03-19 06:54:52.447711
591,ML00008209,,,COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OC[C@H](N)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
592,ML00010900,,,CC[C@H](OC)[C@@H](C)[C@H]1O[C@@H]1[C@H](O)[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010900_numbered.png,2026-03-19 06:54:52.495171
593,ML00002284,,,CC(=C/C[C@H](O)C[C@@H](C)O)/C=C(C)\C=C(C)/C=C/C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 6, 8, 9]",ring_size_12/standard/numbered/ML00002284_numbered.png,2026-03-19 06:54:52.529947
594,ML00007466,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)N[C@@H](c2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
595,ML00000377,CHEMBL393258,LASIODIPLODIN,COc1cc(O)cc2c1C(=O)O[C@@H](C)CCCCCCC2,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00000377_numbered.png,2026-03-19 06:54:52.559962
596,ML00008592,,,C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
597,ML00007982,,,C[C@H]1CCCCC[C@@H](O)C(=O)[C@H](SCC(=O)O)CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 9, 10, 11]",ring_size_12/standard/numbered/ML00007982_numbered.png,2026-03-19 06:54:52.608005
598,ML00009720,,,O=C(C[C@@H]1C/C=C\C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OCCNC1=O)N[C@@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
599,ML00008637,,,C=C1C/C(=C\C)C(=O)O[C@@H]2CCN3C[C@@H](O)[C@H](COC(=O)[C@@]1(C)O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
600,ML00010537,,,CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)C[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](C)(O)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
601,ML00009244,,,CC(C)=CCOc1ccc(C[C@@H]2NC(=O)[C@H](C)[C@@H](O)C[C@H]([C@@H](C)CCCC[C@H](C)O)OC(=O)[C@@H]3CCCCN3C2=O)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
602,ML00002750,,,CC[C@H](O)C[C@H](O)C/C=C(C)/C=C(C)/C=C(C)/C=C/C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 6, 8, 9]",ring_size_12/standard/numbered/ML00002750_numbered.png,2026-03-19 06:54:52.775747
603,ML00000351,CHEMBL1643633,11BETA-METHOXYCURVULARIN,CO[C@@H]1CCC[C@H](C)OC(=O)Cc2cc(O)cc(O)c2C(=O)C1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 9]",ring_size_12/standard/numbered/ML00000351_numbered.png,2026-03-19 06:54:52.822515
604,ML00004048,,,O=C(O)/C=C(\C(=O)O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@H](O)[C@@H](OC(=O)c1cc(O)c(O)c(O)c1)O2)[C@H]1c2c(cc(O)c(O)c2O)C(=O)O[C@@H]1C(=O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
605,ML00007294,,,O=C1CC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CO1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
606,ML00000732,CHEMBL1242284,,CCNC(=O)O[C@H]1CC[C@H](C)[C@@H](/C(C)=C/C=C/[C@@H](C)C[C@H]2O[C@@H]2[C@H](C)[C@@H](O)CC)OC(=O)C[C@H](O)CC[C@@]1(C)O,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00000732_numbered.png,2026-03-19 06:54:52.908373
607,ML00001201,CHEMBL2420603,,CC[C@H](OC)[C@@H](C)[C@H]1O[C@@H]1[C@H](O)[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00001201_numbered.png,2026-03-19 06:54:52.959480
608,ML00004062,,,O=C(O)C[C@@H]1C(=O)O[C@@H]2[C@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]2[C@H](OC(=O)c2cc(O)c(O)c4c2[C@H]1[C@H](O)C(=O)O4)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
609,ML00000944,CHEMBL1939386,EXCOECARIPHENOL D,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c4oc5c(O)c(O)cc(c5c34)C(=O)O[C@@H]3[C@H]1OC(=O)c1cc(O)c(O)c4c1[C@@H]1[C@@]5(C[C@]6(O)OC[C@@H](O)[C@@H]6O[C@@H]5C(O)(O)C(O)(O)[C@]1(O)O4)C(=O)O[C@@H]32)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
610,ML00007844,,,C[C@@H]1O[C@]12C[C@]1(CO1)[C@@](C)(O)C(=O)OCC1=CCN3CC[C@H](OC2=O)[C@@H]13,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
611,ML00002282,,,CC(=C/C[C@H](O)C[C@@H](C)O)/C=C(C)/C=C(C)/C=C/C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 6, 8, 9]",ring_size_12/standard/numbered/ML00002282_numbered.png,2026-03-19 06:54:53.028658
612,ML00001576,CHEMBL1731299,,O=C(N[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)COC1=O)OCC1c2ccccc2-c2ccccc21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
613,ML00007998,,,C[C@@H]1CCC/C=C\[C@H]2CC[C@H](O)[C@H](CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
614,ML00007576,,,O=C(O[C@@H]1O[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@H]2O)[C@@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
615,ML00001018,CHEMBL290432,,CCCCCCC[C@H]1OC(=O)C[C@H](O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
616,ML00010972,,,CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H](CO)OC(=O)/C=C(\O2)[C@@](C)(O)CC3(C)C)[C@@H]1C)c1cccc(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
617,ML00010291,,,C[C@@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
618,ML00000730,CHEMBL1771487,,O=C1CC/C=C/CCC(=O)N(Cc2cccc(/C=N/NC(=O)c3cccc(C(=O)NO)c3)c2)C[C@H](c2ccccc2)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
619,ML00009342,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
620,ML00007025,,,COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OCC(NC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
621,ML00008766,,,C[C@H]1[C@@H](C)[C@](C)(O)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(O)CO)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
622,ML00007959,,,C[C@@H]1C[C@@H]2O[C@H](CC[C@H]2O)CC(=O)Cc2cc(O)cc(O)c2C(=O)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
623,ML00007800,,,COc1cc(O)c2c(c1)CCCCCCC[C@@H](C)OC2=O,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00007800_numbered.png,2026-03-19 06:54:53.140883
624,ML00007078,,,C=C(CC)[C@H](C)C[C@@H]1C[C@H](C)C[C@H](C)C(=O)C[C@H](O)/C(C)=C\C(=O)O1,standard_macrolactone,12.0,,,success,,6.0,"[3, 5, 7, 8, 10, 11]",ring_size_12/standard/numbered/ML00007078_numbered.png,2026-03-19 06:54:53.187495
625,ML00007436,,,CC/C=C\C=C/C(=O)N/C=C/C[C@H]1C[C@@H](O)[C@@H](C)C/C=C\Cc2cccc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 5, 6]",ring_size_12/standard/numbered/ML00007436_numbered.png,2026-03-19 06:54:53.218800
626,ML00006809,,,CC(C)[C@@H]1NC(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
627,ML00007855,,,C=C1C/C(=C/C)C(=O)O[C@@H]2CC[N+]3([O-])CC=C(COC(=O)[C@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
628,ML00009560,,,CC[C@@H](O)[C@@](C)(O)C1OC(=O)[C@@H](C)[C@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H]2O[C@@H]([C@@H]1C)[C@@H]2C,non_standard_macrocycle,12.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
629,ML00008600,,,C/C=C1\CC(C)C(C)(O)C(=O)OCC2CCN3CCC(OC1=O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
630,ML00000985,CHEMBL2381162,,CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4cc(O)ccc4Br)O[C@@]1(C3)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
631,ML00001156,CHEMBL1242654,PLADIENOLIDE E,CC[C@H](O)[C@](C)(O)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)CC[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00001156_numbered.png,2026-03-19 06:54:53.317169
632,ML00010112,,,CO[C@@H]1/C=C\CC[C@H](SC[C@H](N)C(=O)O)CC(=O)O[C@@H](/C(C)=C/[C@@H](C)C(=O)C[C@H](O)CC2CC(=O)NC(=O)C2)[C@H](C)[C@@H]1O,standard_macrolactone,12.0,,,success,,5.0,"[3, 4, 5, 6, 11]",ring_size_12/standard/numbered/ML00010112_numbered.png,2026-03-19 06:54:53.361583
633,ML00002074,CHEMBL2152359,,C[C@H]1[C@@H](c2ccccc2)OC(=O)CC/C=C/C[C@@H](CC(=O)NCc2ccc(Cl)cc2)C(=O)N1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
634,ML00002999,,,COC(=O)C[C@@]12Oc3c(O)c(O)cc(C(=O)O[C@@H]4[C@H]5COC(=O)c6cc(O)c(O)c(O)c6-c6c(cc(O)c(O)c6O)C(=O)O[C@@H]4[C@@H](O)[C@@H](OC(=O)c4cc(O)c(O)c(O)c4)O5)c3[C@@H]1[C@H](C(=O)OC)OC2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
635,ML00004072,,,O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]([C@@H]2OC(=O)c2cc(O)c(O)c(O)c2)[C@H]1OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
636,ML00006991,,,O=C(C[C@@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OCCNC1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
637,ML00009149,,,O=C(O[C@@H]1[C@@H](O)[C@H](O)O[C@@H]2COC(=O)c3cc(c(O)c(O)c3O)-c3c(cc(Oc4c(C(=O)O)cc(O)c(O)c4O)c(O)c3O)C(=O)O[C@H]21)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
638,ML00008521,,,C=C1C/C(=C/C)C(=O)OC2CCN3CC=C(COC(=O)C1(C)OC(C)=O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
639,ML00001962,CHEMBL2152362,,O=C(C[C@@H]1C/C=C/C[C@H](Cc2ccccc2)C(=O)N[C@H](c2ccccc2)COC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
640,ML00001228,CHEMBL1159466,,O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2C2C1=CC(=O)C(O)(O)C2(O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
641,ML00008483,,,C=C1C(=O)O[C@@H]2CC(=O)n3ccc(c32)COC(=O)[C@](C)(OC(C)=O)[C@H](C)[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
642,ML00008083,,,C[C@H]1CCCCC[C@H](O)C(=O)[C@H](O)CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 9, 10, 11]",ring_size_12/standard/numbered/ML00008083_numbered.png,2026-03-19 06:54:53.519601
643,ML00002216,,,C=C1C[C@@]23OC(=O)C/C=C\[C@H]4[C@H]5[C@H](/C=C/CC)[C@H]5[C@H](c5ccc(OC)cc5)[C@@H]4C(=O)OC[C@]2(C)[C@H]3[C@@H]2C=C(CO)C[C@@H]3C(=O)C(C)=C[C@H]3[C@@]12O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
644,ML00008267,,,C/C=C1\C[C@@H](C)[C@](C)(O)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC1=O)[C@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
645,ML00000848,CHEMBL1436969,,O=C(C[C@@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@H]2CCCN2C1=O)N[C@@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
646,ML00007140,,,CC(C)(C)[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
647,ML00008259,,,C[C@@H]1C/C(=C\CO)C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@]1(C)O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
648,ML00008063,,,C[C@H]1C[C@@H](O)CCCCC(=O)CCC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 5, 10]",ring_size_12/standard/numbered/ML00008063_numbered.png,2026-03-19 06:54:53.609207
649,ML00007946,,,C=C1C/C(=C/C)C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
650,ML00007788,,,COc1cc(O)cc2c1C(=O)O[C@@H](C)C[C@@H](O)CCCCC2,standard_macrolactone,12.0,,,success,,2.0,"[3, 5]",ring_size_12/standard/numbered/ML00007788_numbered.png,2026-03-19 06:54:53.649142
651,ML00001972,CHEMBL2417583,,CC[C@H](OC)[C@@H](C)[C@H]1O[C@@H]1[C@H](OC(C)=O)[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](OC(C)=O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00001972_numbered.png,2026-03-19 06:54:53.697562
652,ML00001730,CHEMBL38977,,CCCC[C@H]1OC(=O)C[C@H](OCOC)[C@H](Cc2ccccc2)N(C)C(=O)COC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
653,ML00008669,,,C/C=C1\CC(C)C(C)(O)C(=O)OCC2=CCN3CC(O)C(OC1=O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
654,ML00001055,CHEMBL3400936,,C/C1=C\CCC(C)(O)C(C)OC(=O)Cc2c(Cl)c(O)cc(O)c2C1=O,standard_macrolactone,12.0,,,success,,5.0,"[3, 4, 4, 8, 9]",ring_size_12/standard/numbered/ML00001055_numbered.png,2026-03-19 06:54:53.758644
655,ML00009102,,,O=C1O[C@@H]([C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)c4c3C(=O)O[C@H]2[C@@H]4O)[C@H](O)COC(=O)c2cc(O)c(O)c(O)c2-c2cc1c(O)c(O)c2O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
656,ML00001200,CHEMBL2420695,,CC[C@H](OC)[C@@H](C)[C@H]1O[C@@H]1[C@H](O)[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00001200_numbered.png,2026-03-19 06:54:53.824950
657,ML00007111,,,C[C@@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
658,ML00007580,,,O=C(OC1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC(C2O)C1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
659,ML00006870,,,COc1cc(O)c2c(c1C)C(=O)OC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](CO)CSC2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
660,ML00001865,CHEMBL38248,,COCO[C@H]1CC(=O)O[C@H](C)[C@H](C)C(=O)OCC(=O)N(C)[C@H]1Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
661,ML00002696,,,CCC[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@H]4C(C)=C[C@H]3[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002696_numbered.png,2026-03-19 06:54:53.900438
662,ML00004011,,,O=C(O)/C=C(\C(=O)O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@@H](O)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O2)[C@H]1c2c(cc(O)c(O)c2O)C(=O)O[C@@H]1C(=O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
663,ML00006749,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)O,standard_macrolactone,12.0,,,success,,8.0,"[3, 4, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00006749_numbered.png,2026-03-19 06:54:53.960925
664,ML00007585,,,O=C(O[C@H]1[C@@H](O)O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]1[C@@H]2O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
665,ML00004046,,,O=C1C=C2C(=O)O[C@H]3[C@@H]4OC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)OC[C@H]3O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]4OC(=O)c3cc(O)c(O)c(O)c3[C@H]2[C@H](C(=O)O)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
666,ML00001171,CHEMBL38932,,CCCCCCC[C@@H]1CC(=O)O[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)[C@H](OCOC)CC(=O)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
667,ML00008642,,,C=C1C/C(=C/C)C(=O)O[C@@H]2CC[N+]3([O-])C[C@@H](O)[C@H](COC(=O)[C@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
668,ML00008168,,,COc1c(Br)c(O)c(Br)c2c1C(=O)OC(C)CCCCCCC2,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00008168_numbered.png,2026-03-19 06:54:54.013143
669,ML00001186,CHEMBL3260940,,CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)/C=C\CCc3coc(/C=C\CNC(=O)OC)n3)C[C@H](CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
670,ML00006703,,,CC(=O)O[C@@H](C)[C@@]1(O)C[C@@H](C)[C@](C)(OC(C)=O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
671,ML00008404,,,CC[C@H]1C[C@H](C)[C@](C)(OC(C)=O)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
672,ML00010181,,,O=C1CC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)CO1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
673,ML00008026,,,C[C@H]1CCC/C=C\C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00008026_numbered.png,2026-03-19 06:54:54.065054
674,ML00010296,,,C[C@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
675,ML00003971,,,O=C(O)C[C@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c(O)c2[C@H]1[C@H](O)C(=O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
676,ML00009341,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
677,ML00009131,,,O=C1N[C@@H](c2ccccc2)COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
678,ML00004752,,,C[C@H]1OC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2cccc(O)c2O)[C@@H](C)OC(=O)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2cccc(O)c2O)[C@@H](C)OC(=O)[C@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)c1cccc(O)c1O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
679,ML00002454,,,CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](O)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002454_numbered.png,2026-03-19 06:54:54.139034
680,ML00010541,,,CO[C@@H](CC[C@H](C)[C@H]1O[C@]23C[C@H](OC(=O)C[C@H]([C@@H](C)O)OC(=O)CC(=C(C)CC2(C)C)O3)[C@@H]1C)c1cccc(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
681,ML00008494,,,C/C=C1\C(=O)OC=C2C(=O)OCC[C@@H]3C(=COC(=O)/C3=C\C)C(=O)OCC[C@H]21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
682,ML00004009,,,O=C(O)C[C@@H](C(=O)O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@H](O)[C@@H](OC(=O)c1cc(O)c(O)c(O)c1)O2)[C@H]1c2c(cc(O)c(O)c2O)C(=O)O[C@H]1C(=O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
683,ML00001378,CHEMBL1711308,,O=C1N[C@@H](Cc2c[nH]c3ccccc23)COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
684,ML00009101,,,O=C1OC[C@@H](O)[C@H]([C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)c4c3C(=O)O[C@@H]2[C@H]4O)OC(=O)c2cc(O)c(O)c(O)c2-c2cc1c(O)c(O)c2O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
685,ML00007612,,,CC/C(C)=C1\OC(=O)C(C)C(O)C(Cc2cccnc2)NC(=O)C(NC(=O)c2ncccc2O)C(C)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
686,ML00002698,,,CC[C@H](C)[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002698_numbered.png,2026-03-19 06:54:54.217645
687,ML00008602,,,CC1CC(O)(C(C)Cl)C(=O)OC2CCN3CC=C(COC(=O)C1(C)O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
688,ML00008589,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
689,ML00001017,CHEMBL2311090,,CCCCCCC[C@H]1OC(=O)CC(O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
690,ML00001158,CHEMBL40333,,CCCCCCC[C@H]1OC(=O)C[C@@H](OCOC)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
691,ML00007908,,,C=C1C(=O)OC2CCN3CC=C(COC(=O)C(C)(O)C4(CO4)C1C)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
692,ML00000582,CHEMBL1704624,,O=C(C[C@H]1C/C=C\C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O[C@@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
693,ML00008609,,,C/C=C1\CC(C)C(O)(CO)C(=O)OCC2=CCN3CCC(OC1=O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
694,ML00006751,,,CC[C@H]1OC(=O)[C@@H](C)[C@@H](O[C@@H]2OCC[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@H](C)C(=O)/C=C\[C@@]1(C)O,standard_macrolactone,12.0,,,success,,8.0,"[3, 4, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00006751_numbered.png,2026-03-19 06:54:54.320193
695,ML00006748,,,CC(C)[C@H]1NC(=O)[C@@H](C)[C@@H](O)C[C@H]([C@H](C)CCCC[C@H](C)O)OC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
696,ML00008269,,,C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3(C)CC[C@H](OC1=O)[C@@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
697,ML00008649,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
698,ML00008069,,,C[C@@H]1C[C@@H]2O[C@H]2[C@@H](O)C/C=C\[C@@H](O)CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 11]",ring_size_12/standard/numbered/ML00008069_numbered.png,2026-03-19 06:54:54.372592
699,ML00008366,,,COc1cc(OC(C)=O)cc2c1C(=O)OC(C)CCCCCCC2,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00008366_numbered.png,2026-03-19 06:54:54.396627
700,ML00001033,CHEMBL290635,,CCCCCCC[C@H]1OC(=O)C[C@H](O)[C@H](Cc2ccccc2)N(C)C(=O)C(C)(C)OC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
701,ML00001084,CHEMBL1669762,,CC(=O)Oc1cc2c(c(OC(C)=O)c1)C(=O)O[C@H](C)CCCCCCC2,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00001084_numbered.png,2026-03-19 06:54:54.471749
702,ML00007871,,,C=C1C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@]4(CO4)[C@H]1C)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
703,ML00001059,CHEMBL1079178,,COc1cc(O)c2c(c1)/C=C/C[C@@H](O)[C@@H](O)C(=O)/C(F)=C/OC2=O,standard_macrolactone,12.0,,,success,,4.0,"[4, 5, 6, 7]",ring_size_12/standard/numbered/ML00001059_numbered.png,2026-03-19 06:54:54.524597
704,ML00006780,,,CC[C@H](C)[C@@H]1NC(=O)C[C@H]2[C@@H]3OC(C)(C)O[C@H]3c3cc4c(cc3N2C/C=C\COC1=O)OCO4,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
705,ML00007627,,,O=C(C[C@@H]1C/C=C\C[C@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](c2ccccc2)NC1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
706,ML00010294,,,C[C@@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
707,ML00008587,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
708,ML00006715,,,C/C=C1\C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@@](C)(OC(C)=O)[C@@H](C)[C@@H]1OC(C)=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
709,ML00007537,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)O,standard_macrolactone,12.0,,,success,,8.0,"[3, 4, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007537_numbered.png,2026-03-19 06:54:54.613203
710,ML00009903,,,CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@H]3[C@@H]4C=C5C(=O)[C@H](C)[C@@H](O)CCC[C@H](C6CCC6)OC(=O)C[C@H]5[C@@H]4C=C(C)[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00009903_numbered.png,2026-03-19 06:54:54.648515
711,ML00008072,,,C[C@@H]1C/C=C\[C@H](O)C/C=C\[C@@H](O)CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 11]",ring_size_12/standard/numbered/ML00008072_numbered.png,2026-03-19 06:54:54.677159
712,ML00008925,,,O=C1N[C@H](Cc2ccccc2)COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
713,ML00005855,,,CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@H]3[C@@H]4C=C5C(=O)[C@H](C)[C@@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)CCC[C@H](c6ccoc6)OC(=O)C[C@H]5[C@@H]4C=C(C)[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00005855_numbered.png,2026-03-19 06:54:54.721672
714,ML00009989,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]([C@H](C)CC)NC(=O)CC(=O)[C@H](C)[C@H](/C=C(\C)C[C@H](C)C/C(C)=C/C(=O)O)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
715,ML00008641,,,C[C@H](O)[C@]1(O)C[C@]2(CO)O[C@]2(C)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
716,ML00008258,,,C[C@@H]1C[C@]2(O[C@@H]2C)C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@]1(C)O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
717,ML00001198,CHEMBL3260945,,CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)/C=C(/C)CCc3coc(/C=C\CNC(=O)OC)n3)C[C@H](CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
718,ML00007459,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)NC[C@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
719,ML00007868,,,C=C1C[C@@]2(O[C@@H]2C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
720,ML00008353,,,COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OCC(NC(=O)CCO)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
721,ML00009969,,,CCCCCCC[C@H]1OC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)OC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
722,ML00000990,CHEMBL2323585,PYRIDOMYCIN,CC/C(C)=C1\OC(=O)[C@H](C)[C@H](O)[C@H](Cc2cccnc2)NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
723,ML00003035,,,COC(=O)C[C@@]12Oc3c(O)c(O)cc(C(=O)O[C@@H]4[C@H]5COC(=O)c6cc(O)c(O)c(O)c6-c6c(cc(O)c(O)c6O)C(=O)O[C@@H]4[C@@H](O)[C@@H](OC(=O)c4cc(O)c(O)c(O)c4)O5)c3[C@@H]1[C@@H](C(=O)OC)OC2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
724,ML00008277,,,CC1CC2(OC2C)C(=O)OC2CCN(C)C/C=C(/COC(=O)C1(C)O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
725,ML00002477,,,CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](O)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)[C@@H](O)[C@H]4C=C[C@H]3[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002477_numbered.png,2026-03-19 06:54:54.831418
726,ML00002380,,,CCN[C@@H]1CC[C@@H](O[C@H]2CCC[C@@H](CC)OC(=O)C[C@@H]3C(=C[C@@H]4[C@@H]3C=C(C)[C@@H]3C[C@@H](O[C@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@@H]5OC)C[C@H]43)C(=O)[C@@H]2C)O[C@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002380_numbered.png,2026-03-19 06:54:54.866973
727,ML00001772,CHEMBL1087530,,O=C(C[C@H]1C/C=C/CCC(=O)O[C@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
728,ML00010539,,,CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@@H](C)O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1ccc(Br)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
729,ML00004203,,,O=C(O)C[C@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1C(=O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
730,ML00001386,CHEMBL1727423,,O=C(C[C@@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
731,ML00008634,,,C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
732,ML00002699,,,CC[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](CC)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@H]4C(C)=C[C@H]3[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002699_numbered.png,2026-03-19 06:54:54.943077
733,ML00010799,,,O=C(C[C@@H]1C/C=C\C[C@H](Cc2ccc(F)cc2)C(=O)OC[C@@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
734,ML00000083,CHEMBL1258349,,O=C1C[C@H]2CCC[C@]3(C[C@@H](C[C@@H](CCCCc4ccccc4)O3)OC(=O)C[C@H](CO)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
735,ML00006752,,,C[C@H]1C[C@H](C)[C@H](O[C@@H]2OCC[C@H](N(C)C)[C@H]2O)[C@H](C)C(=O)O[C@H]([C@H](C)O)[C@@H](C)/C=C\C1=O,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00006752_numbered.png,2026-03-19 06:54:55.004960
736,ML00007792,,,COc1cc(O)cc2c1C(=O)O[C@@H](C)CC[C@H](O)CCCC2,standard_macrolactone,12.0,,,success,,2.0,"[3, 6]",ring_size_12/standard/numbered/ML00007792_numbered.png,2026-03-19 06:54:55.031574
737,ML00002749,,,CC[C@H](O)C[C@H](O)C/C=C(C)/C=C(C)\C=C(C)/C=C/C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 6, 8, 9]",ring_size_12/standard/numbered/ML00002749_numbered.png,2026-03-19 06:54:55.065888
738,ML00007412,,,O=C(O)C[C@@H]1C(=O)O[C@@H]2[C@@H](COC(=O)c3cc4c(c(O)c3O)OC(=O)[C@H]41)O[C@@H](OC(=O)/C=C/c1ccc(O)c(O)c1)[C@H](O)[C@H]2O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
739,ML00005026,,,O=C1O[C@H]2[C@@H]3COC(=O)c4cc(Oc5c(C(=O)O[C@H]6[C@H](OC(=O)c7cc(O)c(O)c(O)c7)O[C@H](COC(=O)c7cc(O)c(O)c(O)c7)[C@@H](O)[C@@H]6O)cc(O)c(O)c5O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@@H]2[C@H](OC(=O)c2cc(O)c(O)c4c2[C@H]2C1=CC(=O)C(O)(O)[C@@H]2O4)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
740,ML00008604,,,C[C@H]1[C@@H](C)[C@](C)(O)C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@]1(O)CCl)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
741,ML00009039,,,CC/C=C/[C@H]1CCC[C@H](O)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00009039_numbered.png,2026-03-19 06:54:55.125742
742,ML00007170,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)NCCOC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
743,ML00009873,,,COc1cc2cc(c1Cl)N1C[C@@H](O)[C@](C)(O)C(=O)N[C@@H](C)C(=O)O[C@H](CC1=O)[C@@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C\C=C(\C)[C@@H]2OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
744,ML00006791,,,CC1(C)[C@H]2CC[C@@]13C(=O)N1C(=O)O[C@@H]([C@H]1Cl)C(Cl)(COCc1ccccc1)C(=O)OCCO[C@H]3C2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
745,ML00007843,,,C[C@@H]1O[C@@]12C[C@]1(CO1)[C@@](C)(O)C(=O)OCC1=CCN3CC[C@@H](OC2=O)[C@@H]13,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
746,ML00010433,,,C[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
747,ML00001771,CHEMBL2152373,,O=C(C[C@@H]1C/C=C/CCC(=O)O[C@H](c2ccccc2)CNC1=O)NCc1cccc(Cl)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
748,ML00006931,,,CC[C@@H]1C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@](C)(O)[C@H](C)[C@H]1OC(C)=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
749,ML00011004,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](C(C)(C)C)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
750,ML00007864,,,C/C=C1/C[C@@]2(CO)O[C@]2(C)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
751,ML00010481,,,CCC(=O)[C@H](C)[C@H]1O[C@H]1C[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010481_numbered.png,2026-03-19 06:54:55.228306
752,ML00007856,,,C=C1C/C(=C/C)C(=O)OC2CC[N+]3([O-])CC=C(COC(=O)C1(C)O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
753,ML00007097,,,C[C@H]1COC(=O)[C@@H](CC(=O)OC(C)(C)C)C/C=C\C[C@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
754,ML00001935,CHEMBL1474044,,O=C(C[C@@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@@H]2CCCN2C1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
755,ML00010801,,,O=C(C[C@@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
756,ML00007769,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)NCCOC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
757,ML00008166,,,C/C=C1\C[C@H](C)[C@@H](O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
758,ML00008450,,,CCOc1cc2c(c(OCC)c1)C(=O)O[C@H](C)CCCCCCC2,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00008450_numbered.png,2026-03-19 06:54:55.288988
759,ML00008115,,,C[C@H]1CCC/C=C/C(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00008115_numbered.png,2026-03-19 06:54:55.316519
760,ML00008067,,,C[C@@H]1C[C@@H](O)CC(=O)C/C=C\[C@@H](O)CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 5, 7, 11]",ring_size_12/standard/numbered/ML00008067_numbered.png,2026-03-19 06:54:55.350392
761,ML00011003,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](C(C)(C)C)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
762,ML00000073,CHEMBL2148108,,C[C@H]1[C@@H]2C[C@@]3(O[C@H](CCC3(C)C)CC(=O)O[C@@H](CO)CC(=O)O2)O[C@@H]1CCCCc1cccc(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
763,ML00008927,,,O=C1N[C@@H](Cc2ccccc2)COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
764,ML00007583,,,O=C(O[C@H]1[C@H](O)[C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC[C@H](O2)[C@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
765,ML00008668,,,C/C=C1\C[C@H](C)[C@@](C)(O)C(=O)OCC2=CCN3C[C@@H](O)[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
766,ML00004070,,,O=C(O)/C=C1\C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)C2=CC(O)=C(O)[C@H]3OC(=O)C[C@@H]1[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
767,ML00010431,,,C[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
768,ML00004033,,,O=C(OC1COC(=O)c2cc(c(O)c(O)c2O)-c2c(cc(O)c(O)c2O)C(=O)OC1C1OC(=O)c2cc(O)c(O)c(O)c2-c2c(O)c(O)c(O)c3c2C(=O)OC1C3O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
769,ML00008472,,,C/C=C1/C[C@@H](C)[C@@](C)(OC(C)=O)C(=O)OCc2ccn3c2[C@@H](CC3=O)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
770,ML00008653,,,C/C=C1\CC(C)C(C)(O)C(=O)OCC2=CC[N+]3([O-])CCC(OC1=O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
771,ML00008625,,,C[C@H]1C[C@@]2(O[C@@H]2C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
772,ML00002757,,,CC/C=C/[C@H]1CCC[C@H](O[C@@H]2O[C@H](C)[C@@H](N(C)C)C[C@H]2O)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002757_numbered.png,2026-03-19 06:54:55.473974
773,ML00008763,,,CC1CC(O)(C(C)O)C(=O)OC2CCN3CC=C(COC(=O)C1(C)O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
774,ML00004201,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]3[C@H]1OC(=O)c1cc(O)c(O)c4c1[C@@H]([C@H](O)C(=O)O4)[C@](O)(C(=O)O)C(=O)O[C@@H]32)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
775,ML00008612,,,C/C=C1/C[C@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
776,ML00008116,,,C[C@@H]1CCC/C=C\C(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00008116_numbered.png,2026-03-19 06:54:55.528707
777,ML00001753,CHEMBL2323583,,CC(C)[C@H]1OC(=O)[C@H](C)[C@H](O)[C@H](Cc2cccnc2)NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
778,ML00007028,,,C[C@H]1COC(=O)CC/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
779,ML00008643,,,C/C=C1/C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
780,ML00008273,,,C[C@@H]1O[C@@]12C[C@H](C)[C@@](C)(O)C(=O)OC/C1=C/CN(C)CC[C@@H](OC2=O)C1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
781,ML00008629,,,C/C=C1/C[C@@H](C)[C@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
782,ML00010686,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
783,ML00006720,,,COC(=O)[C@@H]1CSCc2c(O)cccc2C(=O)OCC(NC(=O)[C@H](CO)NC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
784,ML00007071,,,C=C1NC(=O)[C@H](CCCc2ccccc2)NC(=O)[C@H](C(C)C)OC(=O)[C@H](C)NC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
785,ML00008574,,,C[C@@H]1C[C@]2(C)CC(=O)O[C@@H]3CC[N+]4([O-])CC[C@H](COC(=O)[C@]1(C)O2)[C@H]34,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
786,ML00002399,,,C/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)[C@@H](O)[C@H]4C=C[C@H]3[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002399_numbered.png,2026-03-19 06:54:55.629366
787,ML00008376,,,Cc1ccc(S(=O)(=O)N[C@H]2COC(=O)[C@H](C)COC(=O)C/C=C\[C@H]2C)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
788,ML00002401,,,CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](NC)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002401_numbered.png,2026-03-19 06:54:55.671967
789,ML00009664,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
790,ML00009962,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@H]1C/C=C\[C@@H](OC(C)=O)[C@H](C)[C@H](O)C[C@H](O)CC(=O)O1,standard_macrolactone,12.0,,,success,,5.0,"[3, 7, 8, 9, 11]",ring_size_12/standard/numbered/ML00009962_numbered.png,2026-03-19 06:54:55.719901
791,ML00002281,,,CC(=C/C[C@@H](O)C[C@H](C)O)/C=C(C)/C=C(C)/C=C/C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 6, 8, 9]",ring_size_12/standard/numbered/ML00002281_numbered.png,2026-03-19 06:54:55.759015
792,ML00001044,CHEMBL1080091,,O=C(C[C@@H]1C/C=C/CCC(=O)OCCNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
793,ML00001777,CHEMBL2152375,,O=C(C[C@@H]1C/C=C/CCC(=O)N[C@H](C2CCCCC2)COC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
794,ML00008081,,,C[C@@H]1C[C@@H](O)C[C@@H](O)C/C=C\[C@@H](O)CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 5, 7, 11]",ring_size_12/standard/numbered/ML00008081_numbered.png,2026-03-19 06:54:55.810203
795,ML00007604,,,O=C(C[C@H]1C/C=C\C[C@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
796,ML00011021,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](C(C)(C)C)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
797,ML00008482,,,C/C=C1\CC(C)C(C)(OC(C)=O)C(=O)OCc2ccn3c2C(CC3=O)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
798,ML00008074,,,C[C@H]1CCC[C@@H](O)/C=C\[C@H](O)/C=C/C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 10]",ring_size_12/standard/numbered/ML00008074_numbered.png,2026-03-19 06:54:55.869165
799,ML00001720,CHEMBL1669763,,CCC(=O)Oc1cc2c(c(OC(=O)CC)c1)C(=O)O[C@H](C)CCCCCCC2,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00001720_numbered.png,2026-03-19 06:54:55.895391
800,ML00008616,,,C/C=C1/C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
801,ML00006377,,,O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]3[C@@H]2OC(=O)[C@@]24C[C@@]56O[C@@H]2[C@]2(OC[C@H](O)[C@@H]2O)O[C@@]5(O)[C@@]2(O)Oc5c(O)c(O)cc(c5[C@@H]4[C@]26O)C(=O)O[C@H]31)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
802,ML00008310,,,CC[C@H]1C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@](C)(O)[C@H](C)[C@H]1O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
803,ML00006969,,,O=C1O[C@@H](c2ccccc2)C[C@@H](O)[C@H](O)CCCCc2ccccc21,standard_macrolactone,12.0,,,success,,3.0,"[3, 5, 6]",ring_size_12/standard/numbered/ML00006969_numbered.png,2026-03-19 06:54:55.952934
804,ML00008769,,,CC[C@@]1(O)C[C@@H](C)[C@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
805,ML00006948,,,CCCCC[C@@H]1C[C@H](O)CC(=O)O[C@H](CCCCC)C[C@H](O)CC(=O)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
806,ML00008316,,,C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@@H](C2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
807,ML00004059,,,O=C1O[C@@H]2[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](OC(=O)c3cc(O)c(O)c(O)c3)O[C@H](COC(=O)c3cc(O)c(O)c4c3[C@@H]3C1=CC(=O)[C@](O)(O4)C3(O)O)[C@H]2OC(=O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
808,ML00004641,,,CCCCCC/C=C\CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)[C@@H](O)CC(=O)N[C@H](C(=O)N[C@@H]1/C=C\C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)OC1)C(C)C)C(C)C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
809,ML00000023,CHEMBL1425538,,O=C(O[C@@H]1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@@H]2O)[C@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
810,ML00004073,,,O=C(OC1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC(C2OC(=O)c2cc(O)c(O)c(O)c2)C1OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
811,ML00010636,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
812,ML00006865,,,CC(=O)O[C@@]1(C)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC(=O)[C@@]4(C[C@H]1C)O[C@@H]4C)[C@@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
813,ML00010882,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@@H]3CC[C@@H](C)[C@H](O)C[C@@](C)(CC/C=C/C=C\Br)OC(=O)C[C@](O)(C2)O3)[C@H](OC)[C@@H]1OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
814,ML00000978,CHEMBL1159554,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]3[C@@H]2OC(=O)[C@@]24CC(=O)[C@@](O)(O[C@@]25C(=O)O[C@H]2C(O)CO[C@@]25O)C2(O)Oc5c(O)c(O)cc(c5C24)C(=O)C[C@@H]13)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
815,ML00007530,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]([N+](C)(C)[O-])[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)O,standard_macrolactone,12.0,,,success,,8.0,"[3, 4, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007530_numbered.png,2026-03-19 06:54:56.105539
816,ML00010018,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N[C@H](Cc2c[nH]c3ccccc23)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
817,ML00008463,,,COC(=O)[C@H]1NC(=O)C(NC(=O)OC(C)(C)C)COC(=O)c2ccccc2CSC1N,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
818,ML00010850,,,CC(=O)O[C@H]1/C=C\[C@H](C)[C@H](/C(C)=C/C=C/[C@H](C)C[C@H]2O[C@@H]2[C@H](C)[C@@H](O)[C@H](C)O)OC(=O)C[C@H](O)C[C@@H](O)[C@@]1(C)O,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 8, 9, 11]",ring_size_12/standard/numbered/ML00010850_numbered.png,2026-03-19 06:54:56.171419
819,ML00001919,CHEMBL2368723,Tellimagrandin I,O=C(O[C@@H]1[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)C(O)O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3cc(c(O)c(O)c3O)C(=O)O[C@@H]12)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
820,ML00006753,,,CN[C@H]1C[C@@H](C)O[C@@H](O[C@H]2[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@@H](C)[C@@H]([C@@H](C)O)OC(=O)[C@@H]2C)[C@@H]1O,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00006753_numbered.png,2026-03-19 06:54:56.229574
821,ML00001682,CHEMBL40066,,COCO[C@@H]1CC(=O)OC[C@H](C)C(=O)O[C@@H](C(C)C)C(=O)N(C)[C@H]1Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
822,ML00008287,,,C/C=C1\CC(C)C(C)(O)C(=O)OC/C2=C/CN(C)CCC(OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
823,ML00007046,,,COCCOCO[C@@H]1/C=C\COC(=O)/C=C/[C@@H](OC)[C@@H]2CCC(C)=C1C2(C)C,standard_macrolactone,12.0,,,success,,4.0,"[6, 8, 8, 10]",ring_size_12/standard/numbered/ML00007046_numbered.png,2026-03-19 06:54:56.279795
824,ML00007801,,,COc1cc(O)c2c(c1)CCCCCCC[C@H](C)OC2=O,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00007801_numbered.png,2026-03-19 06:54:56.304501
825,ML00001139,CHEMBL1731097,,O=C1N[C@H](Cc2ccccc2)COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
826,ML00010806,,,O=C1OC[C@H]2CCCN2C(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@@H]1Cc1ccc(F)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
827,ML00001953,CHEMBL2420699,,CC[C@H](OC)[C@@H](C)[C@H]1C[C@@H]1[C@@H](O)[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00001953_numbered.png,2026-03-19 06:54:56.363182
828,ML00008578,,,C[C@@H]1C[C@]2(C)CC(=O)O[C@@H]3CCN4CC[C@H](COC(=O)[C@@]1(C)O2)[C@H]34,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
829,ML00008023,,,C[C@H]1CCC(=O)/C=C/C(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 6, 9]",ring_size_12/standard/numbered/ML00008023_numbered.png,2026-03-19 06:54:56.402165
830,ML00006604,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N2CCC[C@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
831,ML00002700,,,CCC1=C[C@H]2[C@@H]3CC(=O)O[C@@H](CC)CCC[C@H](O[C@H]4CC[C@H](N(C)C)[C@@H](C)O4)[C@@H](C)C(=O)C3=C[C@H]2[C@@H]2C[C@H](O[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]3OC)C[C@@H]12,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002700_numbered.png,2026-03-19 06:54:56.447734
832,ML00001014,CHEMBL1242841,PLADIENOLIDE A,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](O)CC[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00001014_numbered.png,2026-03-19 06:54:56.492523
833,ML00008064,,,C[C@@H]1C/C=C\CCCCCCC(=O)O1,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00008064_numbered.png,2026-03-19 06:54:56.516448
834,ML00001712,CHEMBL1394201,,C[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
835,ML00003969,,,O=C(O)/C=C(/C(=O)O[C@@H]1[C@H]2COC(=O)[C@H]3[CH][C@H](O)[C@@H](O)[C@@H](O)[C@H]3[C@@H]3[C@H](O)[C@H](O)[C@@H](O)[CH][C@H]3C(=O)O[C@@H]1[C@H](O)[C@@H](OC(=O)c1cc(O)c(O)c(O)c1)O2)[C@H]1c2c(cc(O)c(O)c2O)C(=O)O[C@@H]1C(=O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
836,ML00008294,,,C[C@@H](O)[C@@]1(O)C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC1=O)[C@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
837,ML00004030,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3cc(c(O)c(O)c3O)C(=O)O[C@H]2[C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]12)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
838,ML00010845,,,CC[C@H]1O[C@H](C[C@@H](C)/C=C/C=C(\C)[C@@H]2OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]2C)[C@@H](O)[C@]1(C)O,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010845_numbered.png,2026-03-19 06:54:56.591090
839,ML00008620,,,C[C@@H]1C[C@]2(C)CC(=O)O[C@@H]3CC[N+]4([O-])CC=C(COC(=O)[C@@]1(C)O2)[C@H]34,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
840,ML00006929,,,CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@@](O)([C@H](C)O)C[C@H]1C)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
841,ML00008282,,,C/C=C1/C[C@@H](C)[C@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
842,ML00008125,,,COC(=O)[C@H](O)CS[C@@H]1CC(=O)O[C@@H](C)CCCCC[C@@H](O)C1=O,standard_macrolactone,12.0,,,success,,4.0,"[3, 9, 10, 11]",ring_size_12/standard/numbered/ML00008125_numbered.png,2026-03-19 06:54:56.643151
843,ML00004077,,,O=C(O)/C=C1\C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1[C@@H](O)C(=O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
844,ML00006917,,,CC(=O)O[C@@]1(C)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC(=O)[C@](O)([C@H](C)O)C[C@@H]1C)[C@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
845,ML00010535,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)/C=C\[C@@](C)(OC(C)=O)[C@H](OC(C)=O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010535_numbered.png,2026-03-19 06:54:56.700460
846,ML00004050,,,O=C(O)C[C@@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1[C@@](O)(C(=O)O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
847,ML00006628,,,CCCCC[C@@H]1OC(=O)c2cc(ccc2C)Oc2ccc(O)c(CO)c2/C=C\[C@@H]1O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
848,ML00001864,CHEMBL38750,,CC(C)[C@@H]1OC(=O)[C@@H](C)COC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
849,ML00000378,CHEMBL1643634,11ALPHA-METHOXYCURVULARIN,CO[C@H]1CCC[C@H](C)OC(=O)Cc2cc(O)cc(O)c2C(=O)C1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 9]",ring_size_12/standard/numbered/ML00000378_numbered.png,2026-03-19 06:54:56.752329
850,ML00006982,,,C=C/C1=C/C(C)C(C)(OC(C)=O)C(=O)OC/C2=C/CN(C)CCC(OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
851,ML00002070,CHEMBL3623742,,Nc1cccc2c1C(=O)O[C@@H](C/C=C/NC(=O)C#Cc1ccccc1)C[C@@H](O)CC/C=C/C2,standard_macrolactone,12.0,,,success,,2.0,"[3, 5]",ring_size_12/standard/numbered/ML00002070_numbered.png,2026-03-19 06:54:56.785054
852,ML00008215,,,C[C@H]1CCC(=O)CCC(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 6, 9]",ring_size_12/standard/numbered/ML00008215_numbered.png,2026-03-19 06:54:56.814093
853,ML00010298,,,C[C@@H]1COC(=O)[C@@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
854,ML00010297,,,C[C@H]1COC(=O)[C@@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
855,ML00001899,CHEMBL1475192,,CO[C@H]1COC(=O)[C@H](C)COC(=O)[C@@H](OCc2ccccc2)/C=C\[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
856,ML00008767,,,CC1C(C)C(O)(CO)C(=O)OCC2=CCN3CCC(OC(=O)C1(C)O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
857,ML00007546,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C/[C@H]1C,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007546_numbered.png,2026-03-19 06:54:56.885205
858,ML00001920,CHEMBL448796,MALLOTINIC ACID,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(Oc4c(C(=O)O)cc(O)c(O)c4O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
859,ML00006990,,,O=C(C[C@H]1C/C=C\C[C@H](Cc2ccc(F)cc2)C(=O)OCCNC1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
860,ML00009103,,,O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@@H](O3)[C@@H](OC(=O)c3cc(O)c(O)c4c3[C@H]3C1=CC(=O)C(O)(O)[C@@]3(O)O4)[C@@H]2O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
861,ML00008468,,,C/C=C1/C[C@H](C)[C@@](C)(OC(C)=O)C(=O)OCc2ccn3c2[C@@H](CC3=O)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
862,ML00006892,,,COc1cc(O)c2c(c1C)C(=O)OC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](C(N)=O)CSC2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
863,ML00001019,CHEMBL269137,HAPALOSIN,CCCCCCC[C@H]1OC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
864,ML00009240,,,CC/C=C/[C@H]1CCC[C@H](O)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00009240_numbered.png,2026-03-19 06:54:56.961913
865,ML00007376,,,CCC(=O)[C@@](C)(O)/C=C/C[C@@H](C)/C=C/[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00007376_numbered.png,2026-03-19 06:54:57.003645
866,ML00007880,,,C=C1C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@H](C)[C@H]1C)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
867,ML00007566,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3c(O)c(O)c(O)c(O)c3-c3c(O)c(O)c(O)c(O)c3C(=O)O[C@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
868,ML00008164,,,COC1=CC(=O)C=C2CCCCC(=O)CC[C@@H](C)OC(=O)[C@@]21O,standard_macrolactone,12.0,,,success,,3.0,"[3, 6, 12]",ring_size_12/standard/numbered/ML00008164_numbered.png,2026-03-19 06:54:57.050343
869,ML00002435,,,CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](C)(O[C@@H]4O[C@@H](C)C(=O)[C@@](C)(O)[C@H]4OC)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
870,ML00007857,,,C=C1C/C(=C\C)C(=O)O[C@@H]2CC[N+]3([O-])CC=C(COC(=O)[C@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
871,ML00002283,,,CC(=C/C[C@@H](O)C[C@H](C)O)/C=C(C)\C=C(C)/C=C/C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 6, 8, 9]",ring_size_12/standard/numbered/ML00002283_numbered.png,2026-03-19 06:54:57.105098
872,ML00001861,CHEMBL1551632,,O=C1CC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NCCO1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
873,ML00001713,CHEMBL2152371,,CC(C)(C)OC(=O)C[C@@H]1C/C=C/CCC(=O)N[C@H](c2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
874,ML00008613,,,C[C@H]1O[C@]12C[C@@](O)(CO)[C@](C)(O)C(=O)OCC1=CCN3CC[C@@H](OC2=O)[C@@H]13,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
875,ML00009340,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
876,ML00009134,,,O=C1NC[C@@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
877,ML00001978,CHEMBL1992836,,O=C(N[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NCCOC1=O)OCC1c2ccccc2-c2ccccc21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
878,ML00000702,CHEMBL506069,GERANIIN,O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]2C1=CC(=O)[C@](O)(O3)C2(O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
879,ML00007657,,,C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)CCCC/C=C/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,2.0,"[3, 4]",ring_size_12/standard/numbered/ML00007657_numbered.png,2026-03-19 06:54:57.196101
880,ML00001203,CHEMBL3260942,,CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)/C=C\CCc3coc(CCCNC(=O)OC)n3)C[C@H](CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
881,ML00000638,CHEMBL1439490,,C=C1C/C(=C/C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
882,ML00007272,,,Cc1cccc2c1C(=O)OC[C@H](NC(=O)C1C(O)CCC1C(=O)C(N)CO)C(=O)N[C@H](C(=O)NC(C)C(=O)O)CSC2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
883,ML00008261,,,C/C=C1/CC[C@@](C)(OC(C)=O)C(=O)OC[C@@]2(O)CCN3CC[C@@H](OC1=O)[C@H]32,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
884,ML00009345,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
885,ML00010797,,,O=C(C[C@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
886,ML00006880,,,CC(=O)O[C@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@]3(C[C@H]1C)O[C@@H]3C)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
887,ML00006825,,,C[C@H](N)C(=O)N1CC[C@@H](O)[C@H]1C(=O)N[C@H]1COC(=O)c2cc(O)cc(O)c2CSC[C@@H](C(=O)NCC(=O)O)NC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
888,ML00000337,CHEMBL4073729,,CC(/C=C/C[C@@H](C)/C=C(C)/C=C/C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(\C)C[C@@H]1C)=C\[C@H](O)[C@@H](O)C[C@H](C)O,standard_macrolactone,12.0,,,success,,4.0,"[3, 6, 8, 9]",ring_size_12/standard/numbered/ML00000337_numbered.png,2026-03-19 06:54:57.338415
889,ML00008275,,,C[C@H]1C[C@]2(O[C@@H]2C)C(=O)O[C@H]2CCN(C)C/C=C(/COC(=O)[C@@]1(C)O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
890,ML00010072,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
891,ML00001011,CHEMBL2381166,,CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4cc(O)ccc4I)O[C@@]1(C3)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
892,ML00008251,,,CC1CCCCCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00008251_numbered.png,2026-03-19 06:54:57.391691
893,ML00009343,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
894,ML00004186,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]3[C@H]1OC(=O)c1cc(O)c(O)c4c1[C@H]1[C@@](O)(C[C@@H](O)[C@@]1(O)O4)C(=O)O[C@@H]32)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
895,ML00006949,,,CCCCC[C@@H]1C[C@@H](O)CC(=O)O[C@H](CCCCC)C[C@@H](O)CC(=O)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
896,ML00008175,,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C(C)=C/OC2=O,standard_macrolactone,12.0,,,success,,4.0,"[4, 5, 6, 7]",ring_size_12/standard/numbered/ML00008175_numbered.png,2026-03-19 06:54:57.449548
897,ML00010075,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
898,ML00004488,,,O=C(NCCCCCC(=O)N1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1)c1cc(O)c(O)c(C(=O)N[C@H]2COC(=O)[C@@H](NC(=O)c3cccc(O)c3O)COC(=O)[C@@H](NC(=O)c3cccc(O)c3O)COC2=O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
899,ML00007859,,,C=C1C/C(=C/C)C(=O)OC2CCN3CC=C(COC(=O)C1(O)CO)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
900,ML00007830,,,C[C@H]1C[C@@H](C)C(=O)/C=C\[C@@H](C)[C@@H]([C@@H](C)O)OC(=O)[C@H](C)[C@H]1O,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007830_numbered.png,2026-03-19 06:54:57.516958
901,ML00010146,,,C[C@@H]1CCCCCCCc2cc(OC(=O)c3ccc(Cl)cc3)cc(OC(=O)c3ccc(Cl)cc3)c2C(=O)O1,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00010146_numbered.png,2026-03-19 06:54:57.541213
902,ML00006760,,,O=C(C[C@@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
903,ML00002806,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H]([C@H]6C[C@@H]6C)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002806_numbered.png,2026-03-19 06:54:57.589168
904,ML00001022,CHEMBL2381167,,COc1cccc(CCCC[C@@H]2C[C@@H]3C[C@@]4(O[C@H](CCC4(C)C)CC(=O)O[C@@H](CO)CC(=O)O3)O2)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
905,ML00002405,,,C/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002405_numbered.png,2026-03-19 06:54:57.637913
906,ML00006747,,,CC(O)CCCCC(C)C1CC(O)C(C)C(=O)N[C@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
907,ML00005567,,,CCCCCC/C=C\CC(=O)N[C@H](C(=O)N[C@@H](CO)[C@@H](O)CC(=O)N[C@H](C(=O)N[C@@H]1/C=C\C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)OC1)C(C)C)C(C)C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
908,ML00007461,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)NC[C@@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
909,ML00001934,CHEMBL1356731,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](c2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
910,ML00000167,CHEMBL473392,ROBOTNIKININ,O=C(C[C@@H]1C/C=C/CCC(=O)O[C@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
911,ML00010071,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
912,ML00010843,,,CC[C@H](O)[C@H](C)[C@H](O)[C@H](O)C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)/C=C\[C@@](C)(O)[C@H](OC(C)=O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010843_numbered.png,2026-03-19 06:54:57.729718
913,ML00004053,,,O=C(O)C[C@]12OC(=O)[C@H](OC1=O)[C@H]2c1c(C(=O)O[C@H]2[C@H](OC(=O)c3cc(O)c(O)c(O)c3)O[C@@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]2[C@@H]3O)cc(O)c(O)c1O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
914,ML00008380,,,C/C=C1\C[C@H](C)[C@@H](OC(C)=O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
915,ML00008245,,,CC1CC(O)CCCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 5]",ring_size_12/standard/numbered/ML00008245_numbered.png,2026-03-19 06:54:57.774305
916,ML00007424,,,COc1ccc2c(c1OC)-c1cc(ccc1O)/C=C\OC(=O)[C@H]1CCCCCCN[C@H]2C1,standard_macrolactone,12.0,,,success,,0.0,[],ring_size_12/standard/numbered/ML00007424_numbered.png,2026-03-19 06:54:57.794529
917,ML00000986,CHEMBL2381163,,CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4cc(O)c(Br)cc4Br)O[C@@]1(C3)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
918,ML00009339,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
919,ML00002849,,,C=C/C=C\[C@H]1[C@@H]2/C=C\CC(=O)O[C@]34C[C@H](C)[C@]5(O)[C@H](C=C(CO)C[C@@]6(O)C(=O)C(C)=C[C@@H]65)[C@H]3[C@]4(C)COC(=O)[C@@H]2[C@H]2[C@@H](/C=C/C=C/C=C/CCC)[C@H]21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
920,ML00009098,,,O=C1OC[C@H]2O[C@@H](O)[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]3[C@@H]2OC(=O)c2cc(O)c(O)c(O)c2-c2cc1c(O)c(O)c2O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
921,ML00008214,,,C[C@@H]1CCC(=O)CCC(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 6, 9]",ring_size_12/standard/numbered/ML00008214_numbered.png,2026-03-19 06:54:57.851243
922,ML00010542,,,CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@@H]([C@@H](C)O)OC(=O)/C=C(\O2)[C@@](C)(O)CC3(C)C)[C@@H]1C)c1cccc(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
923,ML00010552,,,O=C(C[C@@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@H]2CCCN2C1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
924,ML00002991,,,O=C(N[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)COC1=O)OCC1c2ccccc2-c2ccccc21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
925,ML00008667,,,C/C=C1\C[C@@H](C)[C@](C)(O)C(=O)OCC2=CCN3C[C@H](O)[C@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
926,ML00007659,,,C/C(=C\[C@H](C)C(=O)CCCC1CC(=O)NC(=O)C1)[C@H]1OC(=O)/C=C\CC/C=C\C[C@@H](O)[C@@H]1C,standard_macrolactone,12.0,,,success,,3.0,"[3, 4, 5]",ring_size_12/standard/numbered/ML00007659_numbered.png,2026-03-19 06:54:57.908849
927,ML00004197,,,O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(Oc4c(C(=O)OC[C@H]5O[C@H](O)[C@@H](O)[C@H](O)[C@H]5O)cc(O)c(O)c4O)c(O)c3O)C(=O)O[C@H]([C@@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
928,ML00010432,,,C[C@@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
929,ML00000635,CHEMBL1512570,,C[C@H]1C[C@]2(O[C@@H]2C)C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@]1(C)O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
930,ML00007860,,,C=C1C/C(=C\C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@@]1(O)CO)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
931,ML00010136,,,O=C(NC1COC(=O)C(NC(=O)c2cccc(O)c2O)COC(=O)C(NC(=O)c2cccc(O)c2O)COC1=O)c1cccc(O)c1O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
932,ML00007578,,,O=C(O[C@@H]1O[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]([C@@H]2O)[C@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
933,ML00010682,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
934,ML00010278,,,C[C@H](O)CCCC[C@H](C)[C@H]1C[C@H](O)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
935,ML00007146,,,CO[C@H]1/C=C\CC/C=C\C(=O)O[C@H](/C(C)=C/[C@H](C)C(=O)CCCC2CC(=O)NC(=O)C2)[C@@H](C)[C@@H]1O,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 5, 6]",ring_size_12/standard/numbered/ML00007146_numbered.png,2026-03-19 06:54:57.996411
936,ML00011022,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]([C@H](C)CC)NC(=O)CC(=O)[C@H](C)[C@H](/C=C(\C)C[C@H](C)C/C(C)=C/c2cnco2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
937,ML00007651,,,C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\C[C@@H](O)[C@@H]1C,standard_macrolactone,12.0,,,success,,3.0,"[3, 4, 5]",ring_size_12/standard/numbered/ML00007651_numbered.png,2026-03-19 06:54:58.033178
938,ML00007863,,,C/C=C1/C[C@]2(CO)O[C@]2(C)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
939,ML00002067,CHEMBL3621526,,O=C(C#Cc1ccccc1)N/C=C/C[C@H]1C[C@@H](O)CC/C=C/Cc2cc([N+](=O)[O-])ccc2C(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 5]",ring_size_12/standard/numbered/ML00002067_numbered.png,2026-03-19 06:54:58.067089
940,ML00008289,,,C[C@@H]1O[C@]12C[C@@H](C)[C@](C)(O)C(=O)OCC1=CC[N+]3(C)CC[C@@H](OC2=O)[C@]13O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
941,ML00006768,,,Cc1c(O)cc(O)c2c1C(=O)OC[C@H](NC(=O)[C@@H]1[C@H](O)CCN1C(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@H](C(N)=O)CSC2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
942,ML00008210,,,COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OCCC(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
943,ML00005328,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(=O)NCCCC[C@H](NC(=O)c2ccc(C3(C(F)(F)F)N=N3)cc2)C(=O)N(C)CCN(C)C(=O)CCCC[C@H]2SC[C@H]3NC(=O)N[C@H]32)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00005328_numbered.png,2026-03-19 06:54:58.131235
944,ML00007624,,,O=C1CC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
945,ML00007909,,,C=C1C/C(=C/C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
946,ML00010973,,,CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@@H](CO)OC(=O)/C=C(\O2)[C@](C)(O)CC3(C)C)[C@@H]1C)c1cccc(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
947,ML00007853,,,COc1cc2c(c(OC)c1)C(=O)O[C@H](C)CCC/C=C/CC2,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00007853_numbered.png,2026-03-19 06:54:58.173328
948,ML00006622,,,O=C(CN1C/C=C/CCC(=O)N[C@H](c2ccccc2)COC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
949,ML00004205,,,O=C(O)C1=C2c3c(C(=O)O[C@H]4[C@H](OC(=O)c5cc(O)c(O)c(O)c5)O[C@@H]5COC(=O)c6cc(O)c(O)c(O)c6-c6c(cc(O)c(O)c6O)C(=O)O[C@H]4[C@@H]5O)cc(O)c(O)c3O[C@]2(O)C(=O)C1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
950,ML00006450,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]3[C@H]1OC(=O)c1cc(O)c(O)c4c1C1C(O)(O4)[C@]4(O)C[C@@]5(C(=O)O[C@H]6C(O)CO[C@@]65O)[C@]1(CC4=O)C(=O)O[C@@H]32)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
951,ML00001021,CHEMBL40070,,CCCCCCC[C@H]1OC(=O)CC[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
952,ML00010543,,,CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@@H]([C@@H](C)O)OC(=O)/C=C(\O2)[C@](C)(O)CC3(C)C)[C@@H]1C)c1cccc(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
953,ML00008760,,,C[C@@H](O)[C@@]1(O)C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
954,ML00006930,,,CC(=O)OC1(C)C(=O)OC/C2=C/CN(C)CCC(OC(=O)C(O)(C(C)O)CC1C)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
955,ML00008111,,,CO[C@@H]1CC(=O)C/C=C\[C@@H](O)CC(=O)O[C@H](C)C1,standard_macrolactone,12.0,,,success,,4.0,"[3, 5, 7, 11]",ring_size_12/standard/numbered/ML00008111_numbered.png,2026-03-19 06:54:58.255625
956,ML00002078,CHEMBL1688197,,COCCOCO[C@@H]1/C=C\COC(=O)/C=C/[C@@H](OC)[C@@H]2C[C@@H](OC(=O)c3ccccc3)C(C)=C1C2(C)C,standard_macrolactone,12.0,,,success,,4.0,"[6, 8, 8, 10]",ring_size_12/standard/numbered/ML00002078_numbered.png,2026-03-19 06:54:58.291431
957,ML00008665,,,C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3C[C@@H](O)[C@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
958,ML00007471,,,COc1ccc(COC/C=C(\C)[C@@H]2C/C=C/[C@H](OC(C)=O)[C@](C)(O)CCCCC(=O)O2)cc1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 8]",ring_size_12/standard/numbered/ML00007471_numbered.png,2026-03-19 06:54:58.335954
959,ML00001294,CHEMBL1888182,,O=C(N[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](c2ccccc2)COC1=O)OCC1c2ccccc2-c2ccccc21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
960,ML00006607,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)N2CCC[C@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
961,ML00007434,,,CC/C=C\C=C/C(=O)N/C=C\C[C@H]1C[C@@H](O)[C@@H](C)C/C=C/Cc2cccc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 5, 6]",ring_size_12/standard/numbered/ML00007434_numbered.png,2026-03-19 06:54:58.384854
962,ML00008293,,,CC[C@@H]1C(=O)O[C@@H]2CC[N+]3(C)CC=C(COC(=O)[C@](C)(O)[C@H](C)[C@H]1O)[C@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
963,ML00007451,,,O=C1CCC2=C1[C@@H](O)OC1=C2[C@@]2(Cc3ccc(O)c(c3)-c3cc(ccc3O)CCOC2=O)OC1=O,standard_macrolactone,12.0,,,success,,0.0,[],ring_size_12/standard/numbered/ML00007451_numbered.png,2026-03-19 06:54:58.415609
964,ML00010730,,,CCCCCCCCC[C@@]1(CO)CC[C@@H](C)C(=O)O[C@@](CO)(CCCCCCCCC)CC[C@@H](C)C(=O)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
965,ML00001135,CHEMBL3260946,,CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)c3ccccc3CCc3coc(/C=C\CNC(=O)OC)n3)C[C@H](CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
966,ML00008170,,,COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OCC/C(S)=N/1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
967,ML00010532,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)C[C@@H](OC(C)=O)[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 8, 9, 11]",ring_size_12/standard/numbered/ML00010532_numbered.png,2026-03-19 06:54:58.488149
968,ML00010728,,,O=C1O[C@@H]2[C@@H](COC(=O)c3cc(O)c(O)c(O)c3-c3cc1c(O)c(O)c3O)O[C@@H](Oc1cc(O)c(C(=O)c3ccccc3)c(O)c1)[C@H](O)[C@H]2O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
969,ML00007885,,,C[C@@H]1C[C@]2(C)CC(=O)O[C@@H]3CCN4CC=C(COC(=O)[C@@]1(C)O2)[C@H]34,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
970,ML00006928,,,CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@](O)([C@H](C)O)C[C@H]1C)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
971,ML00008768,,,CC[C@]1(O)C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
972,ML00010796,,,O=C1OC[C@@H]2CCCN2C(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@H]1Cc1ccc(F)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
973,ML00011035,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](C(C)(C)C)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
974,ML00008773,,,C/C=C1\C(=O)O[C@@H]2CCN3CC[C@H](COC(=O)[C@](C)(O)[C@H](C)[C@H]1O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
975,ML00000100,CHEMBL525240,CHEBULAGIC ACID,O=C(O)C[C@@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1[C@H](O)C(=O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
976,ML00005726,,,CCCCCC/C=C\CC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CC(=O)N[C@H](C(=O)N[C@@H]1/C=C\C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)OC1)C(C)C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
977,ML00003128,,,C/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C(C(=O)OC)[C@H]1CC(=O)OC[C@H]1[C@H]2C[C@H](OC(=O)C[C@@H]3C(=CO[C@@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)/C3=C/C)C(=O)OC[C@@H]2C)[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
978,ML00007168,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)NCCOC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
979,ML00000706,CHEMBL1240972,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@](C)(O)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(=O)N2CCN(C3CCCCCC3)CC2)CC[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00000706_numbered.png,2026-03-19 06:54:58.627881
980,ML00008163,,,COC1=CC(=O)C=C2CCCC(=O)CCC[C@@H](C)OC(=O)[C@@]21O,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 12]",ring_size_12/standard/numbered/ML00008163_numbered.png,2026-03-19 06:54:58.661334
981,ML00001879,CHEMBL1669772,,CC(=O)Oc1cc2c(c(OC(C)=O)c1)C(=O)OCCCCCCCC2,standard_macrolactone,12.0,,,success,,0.0,[],ring_size_12/standard/numbered/ML00001879_numbered.png,2026-03-19 06:54:58.682108
982,ML00006606,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N2CCC[C@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
983,ML00007304,,,O=C1OCCNC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@H]1Cc1ccc(F)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
984,ML00008153,,,COC1CCC[C@H](C)OC(=O)Cc2cc(O)cc(O)c2C(=O)C1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 9]",ring_size_12/standard/numbered/ML00008153_numbered.png,2026-03-19 06:54:58.729426
985,ML00002812,,,C=C/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)[C@@H](O)[C@H]4C=C[C@H]3[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002812_numbered.png,2026-03-19 06:54:58.771585
986,ML00008638,,,C=C1C/C(=C/C)C(=O)OC2CCN3CC(O)C(COC(=O)C1(C)O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
987,ML00006673,,,CCCCC[C@@H]1OC(=O)c2cc(ccc2C)Oc2c(O)cccc2/C=C\[C@@H]1O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
988,ML00007653,,,C/C(=C\[C@H](C)C(=O)CCCC1CC(=O)NC(=O)C1)[C@H]1OC(=O)/C=C\CC/C=C\[C@H](O)[C@@H](O)[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 5, 6]",ring_size_12/standard/numbered/ML00007653_numbered.png,2026-03-19 06:54:58.832713
989,ML00009142,,,O=C(C[C@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)N[C@@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
990,ML00009931,,,CO[C@@H]1[C@@H](O[C@H]2C[C@@]3(O)O[C@@H](C[C@@H](OC)/C=C(/C)C[C@H](/C=C/C=C/Br)OC(=O)[C@@H]3C)[C@@H]2C)O[C@H](C)[C@@H](OC)[C@@H]1O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
991,ML00007132,,,COc1c(O)cc2c(c1O)C(=O)OC(C)C(O)c1c(O)c(O)c(OC)c(O)c1C(=O)OC(C)C2O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
992,ML00010544,,,CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@@H](C)O)OC(=O)/C=C(\O2)[C@@](C)(O)CC3(C)C)[C@@H]1C)c1cccc(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
993,ML00007623,,,O=C(C[C@@H]1C/C=C\CCC(=O)O[C@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
994,ML00007652,,,C/C(=C\[C@H](C)C(=O)CCCC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\[C@H](O)[C@@H](O)[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 5, 6]",ring_size_12/standard/numbered/ML00007652_numbered.png,2026-03-19 06:54:58.910971
995,ML00008276,,,C[C@H]1C[C@@]2(O[C@@H]2C)C(=O)O[C@H]2CCN(C)C/C=C(/COC(=O)[C@]1(C)O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
996,ML00010078,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
997,ML00008176,,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C(/C)OC2=O,standard_macrolactone,12.0,,,success,,4.0,"[3, 5, 6, 7]",ring_size_12/standard/numbered/ML00008176_numbered.png,2026-03-19 06:54:58.962021
998,ML00010847,,,CC[C@@H](O)/C(C)=C/CC[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010847_numbered.png,2026-03-19 06:54:59.008520
999,ML00001831,CHEMBL1669749,,C[C@@H]1CCCCCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00001831_numbered.png,2026-03-19 06:54:59.032904
1000,ML00008264,,,C[C@H]1C[C@](O)([C@@H](C)Cl)C(=O)O[C@H]2CCN(C)C/C=C(/COC(=O)[C@@]1(C)O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1001,ML00008501,,,COC(=O)[C@@H]1CSCc2c(O)cccc2C(=O)OCC(NC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1002,ML00008800,,,C/C=C1/CO[C@@H]2CCN3C[C@@H](O)[C@H](COC(=O)[C@](C)(O)[C@H](C)C1)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1003,ML00002756,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](/C=C/[C@H](C)O)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002756_numbered.png,2026-03-19 06:54:59.093190
1004,ML00008671,,,C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OC[C@H]2[C@H](O)CN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1005,ML00004047,,,O=C(O)C[C@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1[C@H](O)C(=O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1006,ML00010561,,,O=C(C[C@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@@H]2CCCN2C1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1007,ML00000119,CHEMBL3087768,,CC(=O)OCCOC(=O)[C@@H](CS[C@H]1CCC[C@H](C)OC(=O)Cc2cc(O)cc(O)c2C(=O)C1)OC(C)=O,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 9]",ring_size_12/standard/numbered/ML00000119_numbered.png,2026-03-19 06:54:59.153497
1008,ML00006981,,,C=C/C1=C/[C@H](C)[C@](C)(OC(C)=O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1009,ML00008563,,,C[C@@H]1[C@@H](C)[C@](O)(CCl)C(=O)O[C@H]2CC[N+]3([O-])CC=C(COC(=O)[C@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1010,ML00004028,,,O=C1C[C@]2(O)C(=O)O[C@H]3[C@@H]4OC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)OC[C@H]3O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]4OC(=O)c3cc(O)c(O)c4c3[C@H]2[C@H](O1)C(=O)O4,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1011,ML00007947,,,C=C1C/C(=C/C)C(=O)OC2CCN3CC=C(COC(=O)C1(C)O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1012,ML00007456,,,CCC(C)C1OC(=O)[C@@H](NC(=O)c2cccc(O)c2O)[C@H](C)OC(=O)C(C)(C)OC(CC(C)C)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1013,ML00010080,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1014,ML00009040,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](C6CCC6)CCC[C@H](O)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00009040_numbered.png,2026-03-19 06:54:59.234339
1015,ML00008586,,,C/C=C1/C[C@@H](C)[C@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1016,ML00008274,,,C[C@@H]1O[C@@]12C[C@@H](C)[C@@](C)(O)C(=O)OC/C1=C/CN(C)CC[C@@H](OC2=O)C1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1017,ML00002379,,,CC[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](CC)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002379_numbered.png,2026-03-19 06:54:59.289191
1018,ML00001938,CHEMBL1612084,,CC(C)(C)[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1019,ML00008611,,,C/C=C1\C[C@@H](C)[C@@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1020,ML00001175,CHEMBL2381161,,CC(=O)Nc1ccc(CCCC[C@@H]2C[C@@H]3C[C@@]4(O[C@H](CCC4(C)C)CC(=O)O[C@@H](CO)CC(=O)O3)O2)cc1O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1021,ML00008155,,,COc1cc(O)cc2c1C(=O)O[C@H](C)CCC(=O)CCCC2,standard_macrolactone,12.0,,,success,,2.0,"[3, 6]",ring_size_12/standard/numbered/ML00008155_numbered.png,2026-03-19 06:54:59.336777
1022,ML00007889,,,C/C=C1\C[C@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1023,ML00007021,,,C=CCOc1cc2c(c(OCC=C)c1)C(=O)O[C@H](C)CCCCCCC2,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00007021_numbered.png,2026-03-19 06:54:59.366099
1024,ML00007910,,,CC(=O)N[C@@H]1C/C=C/CCC(=O)N[C@H](c2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1025,ML00000315,CHEMBL281952,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1026,ML00004069,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2OC(=O)c1cc(O)c(O)c(O)c1-c1c(C(=O)O)cc(O)c(O)c1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1027,ML00009495,,,C[C@@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1028,ML00004052,,,O=C(O)C[C@@]1(O)C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1[C@@H](C(=O)O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1029,ML00006695,,,COC(=O)[C@@H]1CSCc2c(N)cccc2C(=O)OCC(NC(=O)[C@H](CO)NC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1030,ML00006842,,,CCCCOc1cc2c(c(OCCCC)c1)C(=O)O[C@H](C)CCCCCCC2,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00006842_numbered.png,2026-03-19 06:54:59.434109
1031,ML00002340,,,CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@H]3[C@@H]4C=C5C(=O)[C@H](C)[C@@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)CCC[C@H](CSC)OC(=O)C[C@H]5[C@@H]4C=C(C)[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002340_numbered.png,2026-03-19 06:54:59.471159
1032,ML00008281,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1033,ML00009049,,,C=C/C=C/[C@H]1CCC[C@H](O)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00009049_numbered.png,2026-03-19 06:54:59.514830
1034,ML00008571,,,CC[C@H]1C[C@@H](C)[C@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1035,ML00010838,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@](C)(O)/C=C/C=C(\C)[C@H]1OC(=O)C[C@@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010838_numbered.png,2026-03-19 06:54:59.563194
1036,ML00001157,CHEMBL1242467,PLADIENOLIDE C,CCC(=O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)CC[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00001157_numbered.png,2026-03-19 06:54:59.604676
1037,ML00008567,,,C[C@H]1C[C@@]2(C)CC(=O)O[C@@H]3CCN4CC[C@H](COC(=O)[C@@]1(C)O2)[C@H]34,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1038,ML00007735,,,CC(=O)Oc1cc(O)cc2c1C(=O)/C=C\CCC[C@H](C)OC(=O)C2,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00007735_numbered.png,2026-03-19 06:54:59.637933
1039,ML00008543,,,C[C@@H]1C[C@@]2(C)CC(=O)O[C@@H]3CCN4CC[C@@H](COC(=O)[C@]1(C)O2)[C@H]34,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1040,ML00001796,CHEMBL1585045,,C/C=C1/CC(C)C(C)(O)C(=O)OCC2CCN3CCC(OC1=O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1041,ML00009976,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C/[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00009976_numbered.png,2026-03-19 06:54:59.692410
1042,ML00011034,,,CCC[C@@H]1C[C@@H](OC)C[C@H](C)C[C@@H]2C[C@H](OC(=O)/C=C\CCc3coc(/C=C\CNC(=O)OC)n3)C[C@H](CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1043,ML00008028,,,C[C@H]1CC/C=C\CC(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00008028_numbered.png,2026-03-19 06:54:59.728453
1044,ML00007353,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1CC/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)CCC(=O)[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 5, 8, 8, 11]",ring_size_12/standard/numbered/ML00007353_numbered.png,2026-03-19 06:54:59.775607
1045,ML00007787,,,COC1=CC(=O)C=C2CCCCCCC[C@@H](C)OC(=O)[C@@]21O,standard_macrolactone,12.0,,,success,,2.0,"[3, 12]",ring_size_12/standard/numbered/ML00007787_numbered.png,2026-03-19 06:54:59.809467
1046,ML00009337,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1047,ML00006884,,,CC(=O)OC1(C)C(=O)OC/C2=C/CN(C)CCC(OC(=O)C3(CC1C)OC3C)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1048,ML00007172,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N[C@H](Cc2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1049,ML00008062,,,C[C@H]1CCCCC[C@@H](O)C(=O)CCC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 9, 10]",ring_size_12/standard/numbered/ML00008062_numbered.png,2026-03-19 06:54:59.864617
1050,ML00006975,,,COC(=O)[C@@H]1CSCc2ccc(O)c(C)c2C(=O)OCC(NC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1051,ML00007518,,,CC(C)(C)[C@H]1COC(=O)CC/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1052,ML00010166,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)[C@H](C)[C@H](O)CC[C@@](C)(O)[C@@H](O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 8, 11, 12]",ring_size_12/standard/numbered/ML00010166_numbered.png,2026-03-19 06:54:59.941962
1053,ML00008039,,,O=C1OCCCCCCCCc2cc(O)cc(O)c21,standard_macrolactone,12.0,,,success,,0.0,[],ring_size_12/standard/numbered/ML00008039_numbered.png,2026-03-19 06:55:00.015007
1054,ML00001377,CHEMBL1729751,,O=C1N[C@H](Cc2c[nH]c3ccccc23)COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1055,ML00007865,,,C/C=C1/C[C@]2(CO)O[C@@]2(C)C(=O)OCC2=CCN3CC[C@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1056,ML00008117,,,C/C=C1/C[C@@H](C)[C@@H](O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1057,ML00001575,CHEMBL1717330,,O=C(N[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)COC1=O)OCC1c2ccccc2-c2ccccc21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1058,ML00007563,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1059,ML00007528,,,CC[C@@H](C)[C@H]1NC(=O)C(C)C(O)CC(C(C)CCCCC(C)O)OC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1060,ML00004198,,,O=C(O[C@@H]1[C@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OC[C@@H](O[C@@H]1Oc1cc(O)c(O)c(O)c1)[C@H]2O)c1cc(O)c(O)c(Oc2cc(O)c(O)c(O)c2C(=O)O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1061,ML00002813,,,C=C/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002813_numbered.png,2026-03-19 06:55:00.110729
1062,ML00007562,,,O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]([C@@H]2O)[C@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1063,ML00008336,,,COC1=CC(O)C2C(=O)O[C@@H](C)CC3CC(=O)[C@@H](O)[C@H](C/C=C/C2=C1)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1064,ML00008100,,,C[C@H]1CCCCC[C@H](O)C(=O)[C@@H](O)CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 9, 10, 11]",ring_size_12/standard/numbered/ML00008100_numbered.png,2026-03-19 06:55:00.161694
1065,ML00008208,,,C[C@H]1CCCCCC(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00008208_numbered.png,2026-03-19 06:55:00.190970
1066,ML00000731,CHEMBL1771486,,O=C1CC/C=C/CCC(=O)N(Cc2cccc(/C=N/NC(=O)c3cccc(C(=O)NO)c3)c2)C[C@@H](c2ccccc2)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1067,ML00009876,,,COc1cc2cc(c1Cl)N1CC[C@](C)(O)C(=O)N[C@@H](C)C(=O)O[C@@H](CC1=O)[C@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C\C=C(\C)[C@H]2OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1068,ML00008519,,,C/C=C1\C[C@@]2(COC(C)=O)O[C@]2(C)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1069,ML00008218,,,C[C@H]1CCC[C@H]2O[C@@H]2C(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00008218_numbered.png,2026-03-19 06:55:00.243150
1070,ML00007952,,,C=C1C/C(=C/C)C(=O)O[C@@H]2C=CN3CC[C@@H](COC(=O)[C@@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1071,ML00000048,CHEMBL449392,CORILAGIN,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1072,ML00008562,,,C[C@@H]1[C@@H](C)[C@](O)(CCl)C(=O)O[C@@H]2CC[N+]3([O-])CC=C(COC(=O)[C@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1073,ML00002804,,,CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002804_numbered.png,2026-03-19 06:55:00.310040
1074,ML00008770,,,CC[C@]1(O)C[C@@H](C)[C@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1075,ML00010805,,,O=C1OC[C@@H]2CCCN2C(=O)[C@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@H]1Cc1ccc(F)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1076,ML00006736,,,O=C(C[C@@H]1CC=CCCC(=O)O[C@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1077,ML00008561,,,C[C@H](Cl)[C@@]1(O)C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1078,ML00008156,,,COc1cc(O)cc2c1C(=O)O[C@@H](C)CC(=O)CCCCC2,standard_macrolactone,12.0,,,success,,2.0,"[3, 5]",ring_size_12/standard/numbered/ML00008156_numbered.png,2026-03-19 06:55:00.363340
1079,ML00010836,,,CC(=O)O[C@H]1/C=C\[C@H](C)[C@H](/C(C)=C/C=C/[C@H](C)C[C@H]2O[C@@H]2[C@H](C)[C@@H](O)[C@H](C)O)OC(=O)C[C@H](O)CC[C@]1(C)O,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010836_numbered.png,2026-03-19 06:55:00.405286
1080,ML00003973,,,O=C(O)C[C@@H](C(=O)O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@@H](O)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O2)[C@H]1c2c(cc(O)c(O)c2O)C(=O)O[C@H]1C(=O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1081,ML00008762,,,C[C@H](O)[C@@]1(O)C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1082,ML00004017,,,O=C1O[C@H]2[C@H](OC(=O)c3cc(O)c(O)c(O)c3)O[C@@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]2[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]2C1=CC(=O)C(O)(O)[C@@]2(O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1083,ML00001791,CHEMBL1591009,SPARTIOIDINE,C=C1C/C(=C\C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1084,ML00007302,,,O=C1NCCOC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1085,ML00000818,CHEMBL1732831,,C[C@@H]1COC(=O)[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1086,ML00008759,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2[C@H](O)C[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1087,ML00007850,,,COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OC[C@H](C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1088,ML00008152,,,CC1CCCC2OC2C(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00008152_numbered.png,2026-03-19 06:55:00.489374
1089,ML00006830,,,CC(C)C(=O)Oc1cc2c(c(OC(=O)C(C)C)c1)C(=O)O[C@H](C)CCCCCCC2,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00006830_numbered.png,2026-03-19 06:55:00.512813
1090,ML00008469,,,C/C=C1/C[C@@H](C)[C@](C)(OC(C)=O)C(=O)OCc2ccn3c2[C@H](CC3=O)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1091,ML00007555,,,CO[C@H](CC(=O)O)[C@@H](C)C(=O)[C@H](C)/C=C(\C)[C@H]1OC(=O)[C@H](O)[C@H](O)/C=C\[C@H](C)CCC[C@@H]1C,standard_macrolactone,12.0,,,success,,5.0,"[3, 4, 8, 11, 12]",ring_size_12/standard/numbered/ML00007555_numbered.png,2026-03-19 06:55:00.555899
1092,ML00005758,,,CCC[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@H]4C(CC)=C[C@H]3[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00005758_numbered.png,2026-03-19 06:55:00.591730
1093,ML00006974,,,COC(=O)[C@@H]1CSCc2c(O)ccc(C)c2C(=O)OCC(NC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1094,ML00004024,,,O=C1O[C@@H]2[C@@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]2[C@H](OC(=O)c2cc(O)c(O)c4c2[C@H]2C1=CC(=O)[C@](O)(O4)C2(O)O)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1095,ML00000262,CHEMBL4105086,,C[C@H]1CCC/C=C/C(=O)c2c(cc(O)c(Cl)c2O)CC(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00000262_numbered.png,2026-03-19 06:55:00.633054
1096,ML00007640,,,C/C=C1/[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OC[C@H](C)[C@]3(O)[C@@H](O)C[C@H](C)[C@H]3COC(=O)C[C@H]21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1097,ML00000596,CHEMBL2152376,,O=C(C[C@@H]1C/C=C/CCC(=O)N[C@H](Cc2ccccc2)COC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1098,ML00008271,,,C[C@H]1C[C@@]2(O[C@@H]2C)C(=O)O[C@@H]2CC[N+]3(C)CC=C(COC(=O)[C@]1(C)O)[C@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1099,ML00008113,,,C[C@H]1CCCCCC[C@H](O)[C@H](O)CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 10, 11]",ring_size_12/standard/numbered/ML00008113_numbered.png,2026-03-19 06:55:00.682084
1100,ML00010196,,,O=C(C[C@@H]1C/C=C\C[C@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](Cc2c[nH]c3ccccc23)NC1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1101,ML00006376,,,O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]3[C@@H]2OC(=O)[C@@]24[C@@H]5c6c(cc(O)c(O)c6O[C@]5(O)[C@@]5(O)O[C@]2(C(=O)O)[C@]2(O)O[C@@]5(O)[C@H]4[C@@]2(O)[C@@H](O)CO)C(=O)O[C@H]31)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1102,ML00008290,,,C[C@@H]1C[C@]2(O[C@@H]2C)C(=O)O[C@@H]2CC[N+]3(C)CC=C(COC(=O)[C@@]1(C)O)[C@@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1103,ML00007095,,,C[C@@H]1COC(=O)[C@@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1104,ML00007907,,,C=C1C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@@]4(CO4)[C@@H]1C)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1105,ML00008626,,,CC1CC2(OC2C)C(=O)OC2CCN3CC=C(COC(=O)C1(C)O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1106,ML00002639,,,CC[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002639_numbered.png,2026-03-19 06:55:00.797073
1107,ML00008020,,,C[C@@H]1CCC(=O)C[C@@H]2Oc3cc(O)cc(c3C2=O)CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 6, 9]",ring_size_12/standard/numbered/ML00008020_numbered.png,2026-03-19 06:55:00.827429
1108,ML00006887,,,C/C=C1/C[C@@H](C)[C@](C)(OC(C)=O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1109,ML00001818,CHEMBL3400934,,C/C1=C\CCC(C)C(C)OC(=O)Cc2cc(O)cc(O)c2C1=O,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 8, 9]",ring_size_12/standard/numbered/ML00001818_numbered.png,2026-03-19 06:55:00.868045
1110,ML00008429,,,CC[C@@H]1C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@@H](C)[C@H]1OC(C)=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1111,ML00008191,,,CC1CCCC(O)CC(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 9]",ring_size_12/standard/numbered/ML00008191_numbered.png,2026-03-19 06:55:00.906576
1112,ML00007482,,,C/C(=C\[C@H](C)C(=O)/C=C/CC1CC(=O)NC(=O)C1)[C@H]1OC(=O)/C=C\CC/C=C\C[C@@H](O)[C@@H]1C,standard_macrolactone,12.0,,,success,,3.0,"[3, 4, 5]",ring_size_12/standard/numbered/ML00007482_numbered.png,2026-03-19 06:55:00.938422
1113,ML00007647,,,C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\[C@H](O)[C@@H](O)[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 5, 6]",ring_size_12/standard/numbered/ML00007647_numbered.png,2026-03-19 06:55:00.972860
1114,ML00007274,,,CC[C@H](C)[C@H]1OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC(=O)[C@@H](C)C(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1115,ML00010692,,,CC/C=C/C=C\CC[C@]1(C)C[C@H](O)[C@H](C)CC[C@H]2C[C@@H](C[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]3OC)C[C@@](O)(CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1116,ML00000155,CHEMBL1396368,,C=C1C/C(=C\C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1117,ML00001690,CHEMBL2152372,,CN1C[C@@H](c2ccccc2)OC(=O)CC/C=C/C[C@@H](Cc2ccc(Cl)cc2)C1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1118,ML00008311,,,CC[C@@H]1C(=O)O[C@@H]2CCN(C)C/C=C(/COC(=O)[C@](C)(O)[C@H](C)[C@H]1O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1119,ML00008485,,,C=C1C(=O)OC2CC(=O)n3ccc(c32)COC(=O)C(C)(OC(C)=O)C(C)C1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1120,ML00010860,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1[C@H](O)[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)/C=C\[C@@](C)(O)[C@H](OC(C)=O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010860_numbered.png,2026-03-19 06:55:01.059812
1121,ML00002066,CHEMBL3623741,,O=C(C#Cc1ccccc1)N/C=C/C[C@H]1C[C@@H](O)CC/C=C/Cc2cccc([N+](=O)[O-])c2C(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 5]",ring_size_12/standard/numbered/ML00002066_numbered.png,2026-03-19 06:55:01.089847
1122,ML00008520,,,C=C1C/C(=C/C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)OC(C)=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1123,ML00010844,,,CC[C@H](O)[C@](C)(O)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010844_numbered.png,2026-03-19 06:55:01.142977
1124,ML00009238,,,CC/C=C/[C@H]1CCC[C@H](O)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5O)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00009238_numbered.png,2026-03-19 06:55:01.180173
1125,ML00007455,,,CC/C=C\C=C/C(=O)N/C=C\C[C@@H]1C[C@H](O)[C@H](C)C/C=C\Cc2cccc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 5, 6]",ring_size_12/standard/numbered/ML00007455_numbered.png,2026-03-19 06:55:01.215119
1126,ML00001951,CHEMBL282159,,CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23CC(OC(=O)C[C@H]([C@@H](C)O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cccc(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1127,ML00003970,,,O=C(O)C[C@@H]1C(=O)O[C@@H]2[C@H]3OC(=O)c4cc(O)c(O)c5c4[C@@H]([C@H](O)C(=O)O5)[C@H](CC(=O)O)C(=O)O[C@@H]2[C@@H](COC(=O)c2cc(O)c(O)c4c2[C@H]1[C@H](O)C(=O)O4)O[C@H]3OC(=O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1128,ML00006918,,,CC[C@@H]1C(=O)O[C@@H]2CC[N+]3(C)CC=C(COC(=O)[C@](C)(O)[C@H](C)[C@H]1OC(C)=O)[C@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1129,ML00009877,,,COc1cc2cc(c1Cl)N1CCC(C)(O)C(=O)NC(C)C(=O)O[C@@H](CC1=O)[C@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C/C=C(\C)C2OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1130,ML00009250,,,CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H]4NC(=O)O[C@@]4(C)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1131,ML00009151,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(Oc4c(C(=O)O)cc(O)c(O)c4O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1132,ML00006986,,,C[C@H]1CCC/C=C\[C@H]2CC[C@H](OC(=O)c3cccc(Br)c3)[C@@H](CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1133,ML00008633,,,C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1134,ML00006866,,,CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@@]3(C[C@H]1C)O[C@@H]3C)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1135,ML00001829,CHEMBL1077886,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C(I)=C/OC2=O,standard_macrolactone,12.0,,,success,,4.0,"[4, 5, 6, 7]",ring_size_12/standard/numbered/ML00001829_numbered.png,2026-03-19 06:55:01.326887
1136,ML00000129,CHEMBL223238,NEOPELTOLIDE,CCC[C@@H]1C[C@H](OC)C[C@H](C)C[C@@H]2C[C@@H](OC(=O)/C=C\CCc3coc(/C=C\CNC(=O)OC)n3)C[C@H](CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1137,ML00008636,,,C/C=C1\C[C@@H](C)[C@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1138,ML00007145,,,CO[C@H]1/C=C/CC/C=C/C(=O)O[C@@H](/C(C)=C/[C@H](C)C(=O)CCCC2CC(=O)NC(=O)C2)[C@@H](C)[C@@H]1O,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 5, 6]",ring_size_12/standard/numbered/ML00007145_numbered.png,2026-03-19 06:55:01.378930
1139,ML00007568,,,O=C(C#Cc1ccccc1)N/C=C/C[C@H]1C[C@@H](O)CC/C=C/Cc2cc(O)ccc2C(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 5]",ring_size_12/standard/numbered/ML00007568_numbered.png,2026-03-19 06:55:01.408218
1140,ML00010516,,,CO[C@H](CC[C@@H](C)[C@@H]1O[C@@]23C[C@@H](OC(=O)C[C@@H]([C@H](C)O)OC(=O)CC(=C(C)CC2(C)C)O3)[C@H]1C)c1cc(O)ccc1Br,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1141,ML00008582,,,C/C=C1/C[C@@H](C)[C@](C)(O)C(=O)OC[C@H]2[C@H](O)CN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1142,ML00009296,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](OC(C)=O)CC[C@](O)(COC(C)=O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00009296_numbered.png,2026-03-19 06:55:01.470271
1143,ML00008426,,,C/C=C1\C[C@H](C)[C@@](C)(OC(C)=O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1144,ML00010582,,,CC/C=C/C=C/CC[C@@]1(C)C[C@@H](O)[C@@H](C)CC[C@@H]2C[C@H](O[C@H]3O[C@H](C)[C@@H](OC)[C@H](O)[C@@H]3OC)C[C@](O)(CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1145,ML00003127,,,C/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C(C(=O)OC)[C@H]1CC(=O)OC[C@H]1[C@H]2C[C@H](OC(=O)C[C@@H]3C(=CO[C@@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)/C3=C/C)C(=O)OC[C@H]2C)[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1146,ML00008058,,,C[C@@H]1CCCC(=O)CCC[C@@H](O)CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 11]",ring_size_12/standard/numbered/ML00008058_numbered.png,2026-03-19 06:55:01.525646
1147,ML00002398,,,CN[C@H]1CC[C@H](O[C@H]2CCC[C@H](/C=C/[C@H](C)O)OC(=O)C[C@@H]3C(=C[C@@H]4[C@H]3C=C[C@@H]3C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]43)C(=O)[C@@H]2C)O[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002398_numbered.png,2026-03-19 06:55:01.564778
1148,ML00000363,CHEMBL2152380,,O=C(C[C@@H]1C/C=C/CCC(=O)N[C@H](c2ccc(Cl)cc2)COC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1149,ML00006717,,,C=C1NC(=O)[C@H](CCCc2ccc(OC)cc2)NC(=O)[C@H](C(C)C)OC(=O)[C@H](C)NC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1150,ML00010837,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@H]1C[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@@H](O)CC[C@@](O)(COC(C)=O)[C@@H](O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010837_numbered.png,2026-03-19 06:55:01.624590
1151,ML00002402,,,CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002402_numbered.png,2026-03-19 06:55:01.664410
1152,ML00000636,CHEMBL1314833,,Cc1ccc(S(=O)(=O)N[C@H]2COC(=O)[C@@H](C)COC(=O)C/C=C\[C@H]2C)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1153,ML00007879,,,C=C1C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@@](C)(O)[C@H](C)[C@H]1C)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1154,ML00008608,,,C/C=C1/C[C@@H](CO)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1155,ML00006827,,,O=C(C[C@@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@@H]2CCCN2C1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1156,ML00009663,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1157,ML00010863,,,CO[C@@H]1[C@H](O)[C@@H](O[C@@H]2C[C@]3(O)CC(=O)O[C@@](C)(CC/C=C/C=C/Br)C[C@H](O)[C@@H](C)CC[C@@H](O3)[C@H]2C)O[C@H](C)[C@H]1OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1158,ML00007650,,,C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\[C@@H](O)C[C@@H]1C,standard_macrolactone,12.0,,,success,,3.0,"[3, 4, 6]",ring_size_12/standard/numbered/ML00007650_numbered.png,2026-03-19 06:55:01.741685
1159,ML00010430,,,C[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1160,ML00007532,,,C[C@H]1C[C@@H](C)C(=O)/C=C\[C@](C)(O)[C@@H]([C@@H](C)O)OC(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H]([NH+](C)C)[C@H]1O,standard_macrolactone,12.0,,,success,,8.0,"[3, 4, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007532_numbered.png,2026-03-19 06:55:01.800947
1161,ML00009904,,,CC/C=C/[C@H]1CCC[C@H](O)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)[C@@H](O)[C@H]4C(C)=C[C@H]3[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00009904_numbered.png,2026-03-19 06:55:01.838918
1162,ML00009129,,,O=C(C[C@H]1C/C=C\C[C@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)N[C@@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1163,ML00009237,,,CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@@H](C)OC(C)=O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cccc(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1164,ML00010300,,,C[C@@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1165,ML00008061,,,C[C@@H]1CCCCC[C@@H](O)[C@H](O)/C=C\C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 9, 10]",ring_size_12/standard/numbered/ML00008061_numbered.png,2026-03-19 06:55:01.892120
1166,ML00001836,CHEMBL3916007,,COc1cc(O)cc2c1C(=O)O[C@@H](C)CCC[C@H](O)CCC2,standard_macrolactone,12.0,,,success,,2.0,"[3, 7]",ring_size_12/standard/numbered/ML00001836_numbered.png,2026-03-19 06:55:01.919795
1167,ML00008422,,,C/C=C1/C[C@@H](COC(C)=O)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1168,ML00008091,,,C[C@H]1CCC/C=C\[C@H]2C=C[C@H](O)[C@H](CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1169,ML00009494,,,C[C@@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1170,ML00008219,,,C[C@H]1CCC[C@H]2O[C@H]2C(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00008219_numbered.png,2026-03-19 06:55:01.970252
1171,ML00008283,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@H](OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1172,ML00001795,CHEMBL1599718,,C/C=C1\C[C@H](C)[C@@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1173,ML00010333,,,CCCCCCC[C@H]1OC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CCSC)OC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1174,ML00006972,,,COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OC[C@@H](NC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1175,ML00008935,,,O=C(C[C@@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O[C@H](c2ccccc2)CNC1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1176,ML00009309,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1177,ML00001194,CHEMBL2420698,,CC[C@H](OC)[C@@H](C)[C@H]1C[C@@H]1[C@@H](O)[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00001194_numbered.png,2026-03-19 06:55:02.060429
1178,ML00007364,,,CC[C@H](O)[C@](C)(O)/C=C/C[C@@H](C)/C=C/[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00007364_numbered.png,2026-03-19 06:55:02.105758
1179,ML00010109,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1180,ML00009056,,,CCCC[C@H]1CCC[C@H](O)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00009056_numbered.png,2026-03-19 06:55:02.151447
1181,ML00000876,CHEMBL1240974,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(=O)NCCCC[C@H](NC(=O)c2ccc(C3(C(F)(F)F)N=N3)cc2)C(=O)N(C)CCN(C)C(=O)CCCC[C@H]2SC[C@H]3NC(=O)N[C@H]32)CC[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00000876_numbered.png,2026-03-19 06:55:02.202355
1182,ML00001794,CHEMBL1321908,,C/C=C1\C[C@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1183,ML00005779,,,CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@H]4C(C)=C[C@H]3[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00005779_numbered.png,2026-03-19 06:55:02.248843
1184,ML00010834,,,CCC(O)C(C)C1OC1CC(C)/C=C/C=C(/C)C1OC(=O)CC(O)CCC(C)(O)C(OC(C)=O)/C=C\C1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010834_numbered.png,2026-03-19 06:55:02.291037
1185,ML00002229,,,O=C(N[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](c2ccccc2)COC1=O)OCC1c2ccccc2-c2ccccc21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1186,ML00010655,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](c2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1187,ML00008771,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1188,ML00000081,CHEMBL1258117,,CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4ccccc4)O[C@@]1(C3)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1189,ML00008577,,,C/C=C1\CC(C)C(C)(O)C(=O)OCC2C(O)CN3CCC(OC1=O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1190,ML00010195,,,O=C(C[C@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](Cc2c[nH]c3ccccc23)NC1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1191,ML00008624,,,C[C@@H]1O[C@@]12C[C@@H](C)[C@@](C)(O)C(=O)OCC1=CCN3CC[C@@H](OC2=O)[C@@H]13,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1192,ML00006755,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00006755_numbered.png,2026-03-19 06:55:02.387659
1193,ML00002702,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3CC[C@H]4[C@@H]5CC(=O)O[C@@H](C6CCC6)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002702_numbered.png,2026-03-19 06:55:02.426456
1194,ML00008265,,,C[C@@H]1O[C@]12C[C@@H](C)[C@@](C)(O)C(=O)OCC1=CC[N+]3(C)CC[C@@H](OC2=O)[C@@]13O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1195,ML00010654,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1196,ML00008246,,,C[C@@H]1CC[C@@H](O)CCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 6]",ring_size_12/standard/numbered/ML00008246_numbered.png,2026-03-19 06:55:02.468372
1197,ML00010634,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1198,ML00007480,,,C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C/CC/C=C/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,2.0,"[3, 4]",ring_size_12/standard/numbered/ML00007480_numbered.png,2026-03-19 06:55:02.505288
1199,ML00004057,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3c(O)c(O)c(O)c(O)c3-c3c(O)c(O)c(O)c(O)c3C(=O)O[C@H]([C@H]1OC(=O)c1cc(O)c(O)c(O)c1)[C@@H]2OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1200,ML00009872,,,COc1cc2cc(c1Cl)N1C[C@@H](O)[C@@](C)(O)C(=O)N[C@H](C)C(=O)O[C@@H](CC1=O)[C@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C\C=C(\C)[C@H]2OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1201,ML00002803,,,CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002803_numbered.png,2026-03-19 06:55:02.563847
1202,ML00001792,CHEMBL1669746,,COc1cc2c(c(OC)c1)C(=O)O[C@H](C)CCC/C=C\CC2,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00001792_numbered.png,2026-03-19 06:55:02.587998
1203,ML00006841,,,CC/C=C/C(C)=C/[C@H](C)C[C@H](O)[C@@H]1/C=C\CC[C@H](C)C(=O)CC[C@H](C)C(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 8, 9, 12]",ring_size_12/standard/numbered/ML00006841_numbered.png,2026-03-19 06:55:02.621901
1204,ML00007533,,,C[C@H]1C[C@@H](C)C(=O)/C=C\[C@](C)(O)[C@@H]([C@@H](C)O)OC(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,12.0,,,success,,8.0,"[3, 4, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007533_numbered.png,2026-03-19 06:55:02.673974
1205,ML00010970,,,CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H](CO)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cc(O)ccc1Br,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1206,ML00010862,,,CC(=O)O[C@H]1/C=C\[C@H](C)[C@H](/C(C)=C/C=C/[C@H](C)C[C@@H](O)/C=C(\C)C(=O)[C@@H](C)O)OC(=O)C[C@H](O)CC[C@@]1(C)O,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010862_numbered.png,2026-03-19 06:55:02.727918
1207,ML00007151,,,CO[C@H]1/C=C\CC/C=C\C(=O)O[C@@H](/C(C)=C/[C@H](C)C(=O)C[C@H](O)CC2CC(=O)NC(=O)C2)[C@@H](C)[C@@H]1O,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 5, 6]",ring_size_12/standard/numbered/ML00007151_numbered.png,2026-03-19 06:55:02.766043
1208,ML00008314,,,C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@@H](C2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1209,ML00006886,,,C/C=C1/C[C@@H](C)[C@@](C)(OC(C)=O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1210,ML00010293,,,C[C@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1211,ML00009150,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3Oc3c(C(=O)O)cc(O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1212,ML00001773,CHEMBL2152360,,O=C(C[C@@H]1C/C=C/CCC(=O)N[C@@H](c2ccccc2)COC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1213,ML00005778,,,CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@H]3[C@@H]4C=C5C(=O)[C@H](C)[C@@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)CCC[C@H]([C@H]6C[C@H]6C)OC(=O)C[C@H]5[C@@H]4C=C(C)[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00005778_numbered.png,2026-03-19 06:55:02.843809
1214,ML00008420,,,C/C=C1\C[C@@H](C)[C@](O)(COC(C)=O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1215,ML00010906,,,CC[C@H](O)[C@@H](C)[C@@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)[C@@H](C)[C@H](O)C[C@@H](O)[C@H](C)[C@H](OC(C)=O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 9, 11, 12]",ring_size_12/standard/numbered/ML00010906_numbered.png,2026-03-19 06:55:02.900151
1216,ML00007569,,,O=C(C[C@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)O[C@H](c2ccccc2)CNC1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1217,ML00006799,,,COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OCC(NC(=O)[C@H](CO)NC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1218,ML00002029,CHEMBL3623743,,O=C(C#Cc1ccccc1)N/C=C/C[C@H]1C[C@@H](O)CC/C=C/Cc2cccc(C(F)F)c2C(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 5]",ring_size_12/standard/numbered/ML00002029_numbered.png,2026-03-19 06:55:02.944165
1219,ML00009100,,,O=C(Oc1cc2c(c(O)c1O)-c1c(cc(O)c(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](O)[C@H](OC2=O)[C@@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1220,ML00007457,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)NC[C@@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1221,ML00001770,CHEMBL2152379,,O=C(C[C@@H]1C/C=C/CCC(=O)N[C@H](c2ccc(F)cc2)COC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1222,ML00007881,,,C=C1C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@@](C)(O)[C@@H](C)[C@H]1C)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1223,ML00008488,,,C=C1C/C(=C/C)C(=O)O[C@@H]2CC(=O)n3ccc(c32)COC(=O)[C@]1(C)OC(C)=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1224,ML00002092,CHEMBL1552334,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N[C@H](C(C)(C)C)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1225,ML00008250,,,C[C@H]1CCCCCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00008250_numbered.png,2026-03-19 06:55:03.011618
1226,ML00002992,,,O=C(N[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)COC1=O)OCC1c2ccccc2-c2ccccc21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1227,ML00003458,,,CC[C@H]1CCC[C@@H](O[C@H]2CC[C@H](N)[C@H](C)O2)[C@H](C)C(=O)C2=C[C@H]3[C@H](C=C[C@H]4C[C@H](O[C@H]5O[C@H](C)[C@@H](OC)[C@H](OC)[C@H]5OC)C[C@@H]43)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00003458_numbered.png,2026-03-19 06:55:03.057182
1228,ML00010301,,,CC(=O)CCCCC(C)C1CC(O)C(C)C(=O)N[C@H](Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1229,ML00005776,,,CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)[C@@H](O)[C@H]4C(C)=C[C@H]3[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00005776_numbered.png,2026-03-19 06:55:03.104424
1230,ML00001633,CHEMBL506817,MALLOTUSINIC ACID,O=C1O[C@H]2[C@@H]3OC(=O)c4cc(Oc5c(C(=O)O)cc(O)c(O)c5O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]2C1=CC(=O)[C@](O)(O3)C2(O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1231,ML00009498,,,COC(=O)Cc1c(C(=O)O[C@H]2[C@H](OC(=O)c3cc(O)c(O)c(O)c3)O[C@@H]3COC(=O)[C@@H]4[CH][C@@H](O)[C@@H](O)[C@@H](O)[C@H]4[C@H]4[C@H]([CH][C@H](O)[C@@H](O)[C@H]4O)C(=O)O[C@H]2[C@@H]3O)cc(O)c(O)c1O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1232,ML00002120,CHEMBL432995,ENTEROBACTIN,O=C(N[C@H]1COC(=O)[C@@H](NC(=O)c2cccc(O)c2O)COC(=O)[C@@H](NC(=O)c2cccc(O)c2O)COC1=O)c1cccc(O)c1O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1233,ML00008154,,,COc1cc(O)cc2c1C(=O)O[C@H](C)CCCCC/C=C\2,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00008154_numbered.png,2026-03-19 06:55:03.158673
1234,ML00002640,,,CCC1CCCC(OC2CCC(N(C)C)C(C)O2)C(C)C(=O)C2=CC3C(C=CC4CC(OC5OC(C)C(OC)C(OC)C5OC)CC43)C2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002640_numbered.png,2026-03-19 06:55:03.196138
1235,ML00010685,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1236,ML00010581,,,CC/C=C/C=C/CC[C@]1(C)C[C@H](O)[C@H](C)CC[C@H]2C[C@@H](O[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]3OC)C[C@@](O)(CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1237,ML00009106,,,O=C(Oc1cc(C(=O)O[C@@H]2O[C@@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]([C@H]2O)[C@@H]3O)cc(O)c1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1238,ML00004489,,,CC(OC(=O)[C@H](C)NC(=O)c1cc(O)c(O)c(C(=O)N[C@H]2COC(=O)[C@@H](NC(=O)c3cccc(O)c3O)COC(=O)[C@@H](NC(=O)c3cccc(O)c3O)COC2=O)c1)OC(=O)N1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1239,ML00008192,,,C[C@@H]1CCC[C@H](O)CC(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 9]",ring_size_12/standard/numbered/ML00008192_numbered.png,2026-03-19 06:55:03.262218
1240,ML00002342,,,CC/C=C/[C@H]1CCC[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](OC)[C@H]2O)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002342_numbered.png,2026-03-19 06:55:03.302574
1241,ML00007534,,,C[C@H]1C[C@@H](C)C(=O)/C=C/[C@](C)(O)[C@@H]([C@@H](C)O)OC(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,12.0,,,success,,8.0,"[3, 4, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007534_numbered.png,2026-03-19 06:55:03.353748
1242,ML00000024,CHEMBL482050,,CC1CCC/C=C/C(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 9]",ring_size_12/standard/numbered/ML00000024_numbered.png,2026-03-19 06:55:03.380382
1243,ML00001251,CHEMBL1563338,,CC(C)(C)[C@H]1COC(=O)[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1244,ML00007771,,,C/C=C1/CC[C@@](C)(O)C(=O)OC[C@@]2(O)CCN3CC[C@@H](OC1=O)[C@H]32,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1245,ML00010722,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(OC(C)=O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010722_numbered.png,2026-03-19 06:55:03.437675
1246,ML00008409,,,CC[C@H]1C[C@H](C)[C@](C)(OC(C)=O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1247,ML00010077,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N2CCC[C@@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1248,ML00010290,,,C[C@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1249,ML00006724,,,O=C(C[C@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@@H]2CCCN2C1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1250,ML00008936,,,O=C(C[C@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O[C@@H](c2ccccc2)CNC1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1251,ML00007579,,,O=C(O[C@H]1O[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@@H]2O)[C@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1252,ML00010329,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@]2(CO2)[C@@H](O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 7, 11]",ring_size_12/standard/numbered/ML00010329_numbered.png,2026-03-19 06:55:03.513360
1253,ML00010118,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3O[C@@](O)(C2)[C@H](C)C(=O)O[C@@H](/C=C/C=C/Br)C/C(C)=C\C(=O)C3(C)C)[C@H](OC)[C@@H]1OC(N)=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1254,ML00004021,,,O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]2C1=CC(=O)C(O)(O)[C@@]2(O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1255,ML00007541,,,C[C@H]1C[C@@H](C)C(=O)/C=C/[C@@H](C)[C@@H]([C@@H](C)O)OC(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007541_numbered.png,2026-03-19 06:55:03.577086
1256,ML00007793,,,COc1cc(O)cc2c1C(=O)O[C@@H](C)CCC[C@@H](O)CCC2,standard_macrolactone,12.0,,,success,,2.0,"[3, 7]",ring_size_12/standard/numbered/ML00007793_numbered.png,2026-03-19 06:55:03.606060
1257,ML00008470,,,C/C=C1/C[C@@H](C)[C@@](C)(OC(C)=O)C(=O)OCc2ccn3c2[C@H](CC3=O)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1258,ML00007484,,,Cc1c(O)cc(O)c2c1C(=O)OC[C@H](NC(=O)[C@@H]1[C@H](O)CCN1C(=O)[C@H](C)N)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)O)CSC2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1259,ML00007517,,,CC(C)(C)[C@H]1COC(=O)CC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1260,ML00010076,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N2CCC[C@@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1261,ML00010842,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)C[C@@H](O)[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 8, 9, 11]",ring_size_12/standard/numbered/ML00010842_numbered.png,2026-03-19 06:55:03.683671
1262,ML00010099,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1263,ML00010480,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@]2(CO2)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 7, 11]",ring_size_12/standard/numbered/ML00010480_numbered.png,2026-03-19 06:55:03.729297
1264,ML00008055,,,C[C@@H]1CCCCCC[C@H](O)/C=C\C(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 10]",ring_size_12/standard/numbered/ML00008055_numbered.png,2026-03-19 06:55:03.756920
1265,ML00007538,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C/[C@]1(C)O,standard_macrolactone,12.0,,,success,,8.0,"[3, 4, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007538_numbered.png,2026-03-19 06:55:03.812201
1266,ML00008572,,,CC[C@H]1C[C@H](C)[C@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1267,ML00007169,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)NCCOC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1268,ML00007636,,,C/C=C1\C(OC2OC(CO)C(O)C(O)C2O)OC=C2C(=O)OCC(C)C3CC(O)C(C)C3COC(=O)CC21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1269,ML00007309,,,O=C(C[C@@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OCCNC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1270,ML00008746,,,C[C@@H]1[C@@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC(=O)[C@@]1(O)CO)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1271,ML00010169,,,C[C@@H]1CCCCCCCc2cc(OCc3ccc([N+](=O)[O-])cc3)cc(OCc3ccc([N+](=O)[O-])cc3)c2C(=O)O1,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00010169_numbered.png,2026-03-19 06:55:03.873230
1272,ML00009234,,,CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@@H](NC=O)[C@@](C)(O)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1273,ML00007026,,,COC(=O)[C@@H]1CSCc2c(OC)cc(O)c(C)c2C(=O)OCC(NC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1274,ML00008623,,,C[C@@H]1O[C@@]12C[C@H](C)[C@@](C)(O)C(=O)OCC1=CCN3CC[C@@H](OC2=O)[C@H]13,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1275,ML00007110,,,C[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1276,ML00009338,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1277,ML00007878,,,C=C1C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@H](C)[C@H]1C)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1278,ML00010483,,,CC(C)(C)[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1279,ML00006881,,,CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@@]3(C[C@H]1C)O[C@H]3C)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1280,ML00001160,CHEMBL3260947,,CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)/C=C\CCc3coc(C=C(C)C)n3)C[C@H](CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1281,ML00008583,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2[C@H](O)CN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1282,ML00007248,,,CO[C@H]1/C=C\CC/C=C\C(=O)O[C@H](/C(C)=C/[C@H](C)C(=O)/C=C/CC2CC(=O)NC(=O)C2)[C@@H](C)[C@@H]1O,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 5, 6]",ring_size_12/standard/numbered/ML00007248_numbered.png,2026-03-19 06:55:03.979861
1283,ML00010149,,,C[C@@H]1CCCCCCCc2cc(OC(=O)c3ccccc3)cc(OC(=O)c3ccccc3)c2C(=O)O1,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00010149_numbered.png,2026-03-19 06:55:04.003727
1284,ML00007867,,,C/C=C1/C[C@@]2(CO)O[C@@]2(C)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1285,ML00008205,,,CC1CCC(=O)CCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 6]",ring_size_12/standard/numbered/ML00008205_numbered.png,2026-03-19 06:55:04.037437
1286,ML00008260,,,C/C=C1/C[C@H](CO)[C@@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1287,ML00008601,,,C[C@@H]1C[C@]2(C)CC(=O)O[C@@H]3CCN4CC[C@H](COC(=O)[C@]1(C)O2)[C@H]34,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1288,ML00002228,,,O=C(N[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=O)OCC1c2ccccc2-c2ccccc21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1289,ML00005118,,,O=C1O[C@H]2[C@H]3COC(=O)c4cc(Oc5c(C(=O)O[C@@H]6O[C@H]7COC(=O)c8cc(O)c(O)c(O)c8-c8c(cc(O)c(O)c8O)C(=O)O[C@H]7[C@H](OC(=O)c7cc(O)c(O)c(O)c7)[C@H]6OC(=O)c6cc(O)c(O)c(O)c6)cc(O)c(O)c5O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]2[C@@H](OC(=O)c2cc(O)c(O)c4c2[C@@H]2C1=CC(=O)C(O)(O)[C@@]2(O)O4)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1290,ML00008051,,,C[C@@H]1CCCCCC/C=C\CC(=O)O1,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00008051_numbered.png,2026-03-19 06:55:04.097473
1291,ML00008212,,,C[C@@H]1CCC(=O)[C@@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 6, 7, 9]",ring_size_12/standard/numbered/ML00008212_numbered.png,2026-03-19 06:55:04.132937
1292,ML00005752,,,CC[C@H](C)[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@H]4C(C)=C[C@H]3[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00005752_numbered.png,2026-03-19 06:55:04.172780
1293,ML00007918,,,C=C1C/C(=C/C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@@]1(C)O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1294,ML00010417,,,C[C@@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1295,ML00010069,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N2CCC[C@@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1296,ML00008591,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@@H]2CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1297,ML00007535,,,CC[C@H]1OC(=O)[C@@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@H](C)C(=O)/C=C\[C@@]1(C)O,standard_macrolactone,12.0,,,success,,8.0,"[3, 4, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007535_numbered.png,2026-03-19 06:55:04.253424
1298,ML00007462,,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)NCCO)C(=O)NC[C@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1299,ML00008428,,,C/C=C1/C[C@@H](C)[C@@](C)(OC(C)=O)C(=O)OC[C@H]2[C@H](O)CN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1300,ML00007849,,,COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OC[C@@H](C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1301,ML00007638,,,C/C=C1/[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OC[C@H](C)[C@]3(O)CC[C@H](C)[C@H]3COC(=O)C[C@H]21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1302,ML00001174,CHEMBL2381160,,CC(=O)Nc1ccc(O)cc1CCCC[C@@H]1C[C@@H]2C[C@@]3(O[C@H](CCC3(C)C)CC(=O)O[C@@H](CO)CC(=O)O2)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1303,ML00008065,,,C[C@H]1C/C=C\CCCCCCC(=O)O1,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00008065_numbered.png,2026-03-19 06:55:04.312395
1304,ML00006375,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]3[C@H]1OC(=O)c1cc(O)c(O)c4c1C1C5(C[C@]6(O)OC[C@@H](O)[C@@H]6C[C@@H]5C(O)(O)C(O)(O)[C@]1(O)O4)C(=O)O[C@@H]32)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1305,ML00006934,,,COc1cc(O)c2c(c1C)C(=O)OC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](C(=O)O)CSC2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1306,ML00008635,,,C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1307,ML00008619,,,C/C=C1/C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1308,ML00008315,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC/C2=C/CN(C)CC[C@@H](C2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1309,ML00007997,,,C[C@H]1CCC/C=C\[C@H]2CC[C@H](O)[C@@H](CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1310,ML00002105,CHEMBL2420696,,CC[C@H](OC)[C@@H](C)[C@H]1O[C@@H]1[C@@H](O)[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00002105_numbered.png,2026-03-19 06:55:04.396057
1311,ML00001721,CHEMBL37203,,CC(C)[C@@H]1OC(=O)[C@@H](C)[C@@H](C)OC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1312,ML00008614,,,C/C=C1/C[C@H](C)[C@@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1313,ML00000647,CHEMBL1725065,,O=C(N[C@@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=O)OCC1c2ccccc2-c2ccccc21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1314,ML00008580,,,C/C=C1/C[C@@H](C)[C@](C)(O)C(=O)OC[C@H]2[C@H](O)CN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1315,ML00002403,,,CC/C=C/[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5O)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002403_numbered.png,2026-03-19 06:55:04.458945
1316,ML00004208,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2OC(=O)[C@H]1CC(=O)c2oc(=O)c3cc(O)c(O)c(O)c3c21)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1317,ML00003369,,,O=C(C[C@@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1318,ML00006620,,,CC(=O)O[C@H](C)[C@@]1(O)C[C@@H](C)[C@@](C)(OC(C)=O)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC1=O)[C@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1319,ML00005116,,,O=C1O[C@H]2[C@@H]3COC(=O)c4cc(Oc5c(C(=O)O[C@@H]6[C@@H](OC(=O)c7cc(O)c(O)c(O)c7)O[C@@H](COC(=O)c7cc(O)c(O)c(O)c7)[C@@H](OC(=O)c7cc(O)c(O)c(O)c7)[C@H]6OC(=O)c6cc(O)c(O)c(O)c6)cc(O)c(O)c5O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@@H]2[C@H](C(=O)Oc2cc(O)c(O)c4c2[C@@H]2C1=CC(=O)[C@](O)(O4)C2(O)O)[C@@H](OC(=O)c1cc(O)c(O)c(O)c1)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1320,ML00007411,,,O=C(O)C[C@@H]1C(=O)O[C@@H]2[C@@H](COC(=O)c3cc4c(c(O)c3O)OC(=O)[C@H]41)O[C@@H](OC(=O)/C=C\c1ccc(O)c(O)c1)[C@H](O)[C@H]2O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1321,ML00009133,,,O=C1O[C@@H](c2ccccc2)CNC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@H]1Cc1ccc(F)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1322,ML00008651,,,C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1323,ML00007540,,,C[C@H](O)[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007540_numbered.png,2026-03-19 06:55:04.579790
1324,ML00009105,,,O=C1O[C@@H]2[C@@H]3COC(=O)C4=CC(=O)[C@]5(O)Oc6c(O)c(O)cc(c6[C@H]4C5(O)O)C(=O)O[C@H]2[C@H](OC(=O)c2cc(O)c(O)c4c2[C@@H]2C1=CC(=O)[C@](O)(O4)C2(O)O)[C@H](O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1325,ML00007000,,,C[C@@H]1C(=O)O[C@@H]2CC(=O)n3ccc(c32)COC(=O)[C@]2(C)CCOC(=O)[C@]2(C)[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1326,ML00000998,CHEMBL290049,,CCCCCCC[C@H]1OC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C(=O)COC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1327,ML00000115,CHEMBL3087767,,COC(=O)[C@H](O)CS[C@H]1CCC[C@H](C)OC(=O)Cc2cc(O)cc(O)c2C(=O)C1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 9]",ring_size_12/standard/numbered/ML00000115_numbered.png,2026-03-19 06:55:04.634097
1328,ML00009162,,,CCC[C@H](O)[C@@H](C)C(=O)NC/C=C\C[C@H](C)[C@H](O)[C@H](C)[C@@H]1C/C=C\C[C@H](C)[C@H](O)Cc2cc(OC)cc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 8, 9]",ring_size_12/standard/numbered/ML00009162_numbered.png,2026-03-19 06:55:04.666149
1329,ML00008628,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1330,ML00006895,,,CC(=O)C[C@@H](O)CC(=O)[C@@H]1OC(=O)CCCCCCCc2ccccc21,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00006895_numbered.png,2026-03-19 06:55:04.696893
1331,ML00004282,,,CC[C@H]1CCC[C@H](O[C@@H]2CC[C@@H](NC)[C@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@H]4C[C@H](O[C@@H]5O[C@H](C)[C@H](OC)[C@H](OC)[C@@H]5OC)C[C@@H]4C=C[C@@H]3[C@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00004282_numbered.png,2026-03-19 06:55:04.732587
1332,ML00002050,CHEMBL2152365,,C[C@H]1[C@@H](c2ccccc2)OC(=O)CCCCC[C@@H](CC(=O)NCc2ccc(Cl)cc2)C(=O)N1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1333,ML00007915,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCc2ccn3c2[C@@H](CC3=O)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1334,ML00002321,,,COC(=O)[C@H]1OC(=O)c2cc(O)c(O)c(O)c2[C@@H]1[C@H](CC(=O)O)C(=O)O[C@@H]1[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@@H](O)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1335,ML00008041,,,O=C1CCC=CCCOC(=O)c2c(O)cc(O)c(Cl)c2C1,standard_macrolactone,12.0,,,success,,1.0,[9],ring_size_12/standard/numbered/ML00008041_numbered.png,2026-03-19 06:55:04.779572
1336,ML00008640,,,C/C=C1/C[C@@H](C)[C@H](O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1337,ML00008244,,,C[C@@H]1C[C@H](O)CCCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 5]",ring_size_12/standard/numbered/ML00008244_numbered.png,2026-03-19 06:55:04.812731
1338,ML00004049,,,O=C(O)/C=C(/C(=O)O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@@H](O)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O2)[C@H]1c2c(cc(O)c(O)c2O)C(=O)O[C@@H]1C(=O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1339,ML00007832,,,CC[C@H]1OC(=O)[C@@H](C)[C@@H](O)[C@@H](C)C[C@H](C)C(=O)/C=C\[C@@]1(C)O,standard_macrolactone,12.0,,,success,,8.0,"[3, 4, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007832_numbered.png,2026-03-19 06:55:04.869375
1340,ML00003837,,,O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]3[C@H]2OC(=O)c2cc(O)c(O)c4oc5c(O)c(O)cc(c5c24)C(=O)O[C@@H]13)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1341,ML00008579,,,C/C=C1/CC(C)C(C)(O)C(=O)OCC2C(O)CN3CCC(OC1=O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1342,ML00010236,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@](C)(O)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010236_numbered.png,2026-03-19 06:55:04.925570
1343,ML00006761,,,C[C@H](N)C(=O)N1CC[C@@H](O)[C@H]1C(=O)N[C@H]1COC(=O)c2cc(O)cc(O)c2CSC[C@@H](C(=O)N[C@@H](C)C(=O)O)NC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1344,ML00011031,,,CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H](CO)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cccc(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1345,ML00008077,,,C[C@H]1CCC/C=C\C/C=C\CC(=O)O1,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00008077_numbered.png,2026-03-19 06:55:04.964972
1346,ML00002846,,,C=C[C@H]1[C@@H]2[C@@H]3/C=C\CC(=O)O[C@@]45C[C@@H](C)[C@@]6(O)[C@@H](C=C(CO)C[C@]7(O)C(=O)C(C)=C[C@H]76)[C@@H]4[C@@]5(C)COC(=O)[C@H]3[C@@H](/C=C/C=C/C=C/C=C/CCC)[C@H]12,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1347,ML00008534,,,C/C=C1\C[C@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1348,ML00002114,CHEMBL1562866,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1349,ML00001844,CHEMBL1080988,,O=C(C[C@H]1C/C=C/CCC(=O)OCCNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1350,ML00007854,,,COc1cc2c(c(OC)c1)C(=O)O[C@H](C)CCCC/C=C/C2,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00007854_numbered.png,2026-03-19 06:55:05.016752
1351,ML00005777,,,CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@H]3[C@@H]4C=C5C(=O)[C@H](C)[C@@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)CCC[C@H](C6CCC6)OC(=O)C[C@H]5[C@@H]4C=C(C)[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00005777_numbered.png,2026-03-19 06:55:05.053994
1352,ML00007785,,,C[C@@H]1C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@H](O)[C@@H](C)[C@H]1C)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1353,ML00008918,,,O=C1OC[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@H]1Cc1ccc(F)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1354,ML00007254,,,CO[C@H]1/C=C/CC/C=C/C(=O)O[C@@H](/C(C)=C/[C@H](C)C(=O)/C=C/CC2CC(=O)NC(=O)C2)[C@@H](C)[C@@H]1O,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 5, 6]",ring_size_12/standard/numbered/ML00007254_numbered.png,2026-03-19 06:55:05.104741
1355,ML00008584,,,C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OC[C@H]2[C@H](O)CN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1356,ML00008588,,,C/C=C1/C[C@@H](C)[C@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1357,ML00008672,,,C/C=C1/C(=O)O[C@@H]2CCN3CC[C@H](COC(=O)[C@](C)(O)[C@H](C)[C@H]1O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1358,ML00002227,,,O=C(C[C@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O[C@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1359,ML00000584,CHEMBL1726132,,O=C(N[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=O)OCC1c2ccccc2-c2ccccc21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1360,ML00007976,,,COc1cc(O)cc2c1C(=O)O[C@H](C)CCCCCCC2,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00007976_numbered.png,2026-03-19 06:55:05.164323
1361,ML00006971,,,COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OC[C@H](NC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1362,ML00010877,,,CC[C@H](O)[C@H](C)[C@H](O)[C@H](O)C[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010877_numbered.png,2026-03-19 06:55:05.212753
1363,ML00001143,CHEMBL3347530,,CCCCCCCCCCC[C@]1(CO)CCCC(=O)O[C@](CO)(CCCCCCCCCCC)CCCC(=O)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1364,ML00008266,,,C/C=C1\C[C@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3(C)CC[C@H](OC1=O)[C@@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1365,ML00007252,,,CC[C@H](C)[C@H]1OC(=O)[C@@H](NC(=O)c2cccc(O)c2O)[C@@H](C)OC(=O)C(C)(C)C(=O)[C@@H](CC(C)C)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1366,ML00007977,,,COc1cc(O)cc2c1C(=O)OC(C)CCCCCCC2,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00007977_numbered.png,2026-03-19 06:55:05.257985
1367,ML00002635,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](CSC)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002635_numbered.png,2026-03-19 06:55:05.306378
1368,ML00000112,CHEMBL3087769,,C[C@H]1CCC[C@H](SC[C@@H](O)C(=O)O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 9]",ring_size_12/standard/numbered/ML00000112_numbered.png,2026-03-19 06:55:05.338214
1369,ML00004019,,,O=C1OC2C3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC2C(OC(=O)c2cc(O)c(O)c4c2C2C1=CC(=O)C(O)(O)C2(O)O4)C(OC(=O)c1cc(O)c(O)c(O)c1)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1370,ML00007433,,,CC/C=C\C=C/C(=O)N/C=C/C[C@H]1C[C@@H](O)[C@@H](C)C/C=C/Cc2cccc(O)c2C(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 5, 6]",ring_size_12/standard/numbered/ML00007433_numbered.png,2026-03-19 06:55:05.376943
1371,ML00004659,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(=O)NCCOCCOCCNC(=O)CCCCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)/C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00004659_numbered.png,2026-03-19 06:55:05.420740
1372,ML00010324,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@@H]3CC[C@@H](C)[C@H](O)C[C@@](C)(/C=C/C=C/Br)OC(=O)C[C@](O)(C2)O3)[C@H](OC)[C@@H]1OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1373,ML00001867,CHEMBL1442330,,CC(=O)O[C@]1(C)C(=O)OC/C2=C/CN(C)CCC(OC(=O)[C@@](O)(C(C)O)C[C@H]1C)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1374,ML00008162,,,CO[C@@H]1CCC[C@@H](C)OC(=O)c2c(O)cc(O)cc2CC(=O)C1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 9]",ring_size_12/standard/numbered/ML00008162_numbered.png,2026-03-19 06:55:05.464028
1375,ML00000274,CHEMBL3220169,,CC(=O)O[C@H]1/C=C/C[C@@H](/C(C)=C/C=C/CC[C@H]2O[C@@H]2C[C@H](C)O[Si](C)(C)C(C)(C)C)OC(=O)CCCC[C@@]1(C)O,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 8]",ring_size_12/standard/numbered/ML00000274_numbered.png,2026-03-19 06:55:05.498403
1376,ML00007539,,,C[C@H]1C[C@@H](C)C(=O)/C=C\[C@@H](C)[C@@H]([C@@H](C)O)OC(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/ML00007539_numbered.png,2026-03-19 06:55:05.542367
1377,ML00009124,,,O=C(Oc1cc2c(c(O)c1O)-c1c(cc(O)c(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](O)[C@@H](OC2=O)[C@@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1378,ML00008118,,,COC(=O)C(O)CSC1CC(=O)OC(C)CCCCCC(O)C1=O,standard_macrolactone,12.0,,,success,,4.0,"[3, 9, 10, 11]",ring_size_12/standard/numbered/ML00008118_numbered.png,2026-03-19 06:55:05.583003
1379,ML00010180,,,C[C@H]1COC(=O)[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1380,ML00007175,,,CO[C@H]1/C=C\CC/C=C\C(=O)O[C@H](/C(C)=C/[C@H](C)C(=O)C[C@H](O)CC2CC(=O)NC(=O)C2)[C@@H](C)[C@@H]1O,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 5, 6]",ring_size_12/standard/numbered/ML00007175_numbered.png,2026-03-19 06:55:05.623583
1381,ML00010841,,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1[C@H](O)[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010841_numbered.png,2026-03-19 06:55:05.665464
1382,ML00007649,,,C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)/C=C\CC/C=C\[C@H](O)C[C@@H]1C,standard_macrolactone,12.0,,,success,,3.0,"[3, 4, 6]",ring_size_12/standard/numbered/ML00007649_numbered.png,2026-03-19 06:55:05.696667
1383,ML00008423,,,CC(=O)O[C@@]1(C)C(=O)OCC2=CCN3CC[C@@H](OC(=O)[C@@]4(C[C@@H]1C)O[C@H]4C)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1384,ML00002065,CHEMBL3623740,,O=C(C#Cc1ccccc1)N/C=C/C[C@H]1C[C@@H](O)CC/C=C/Cc2cccc(F)c2C(=O)O1,standard_macrolactone,12.0,,,success,,2.0,"[3, 5]",ring_size_12/standard/numbered/ML00002065_numbered.png,2026-03-19 06:55:05.729697
1385,ML00008478,,,COc1cc(O)c2c(c1OC)/C=C\C[C@@H]1O[C@H](CC(=O)[C@H]1O)C[C@H](C)OC2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1386,ML00007772,,,C/C=C1/CC[C@@](C)(O)C(=O)OC[C@@]2(O)CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1387,ML00006973,,,COC(=O)[C@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OC[C@H](NC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1388,ML00008646,,,C/C=C1\CC(C)C(O)(CO)C(=O)OCC2=CC[N+]3([O-])CCC(OC1=O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1389,ML00006847,,,CCCC(=O)Oc1cc2c(c(OC(=O)CCC)c1)C(=O)O[C@H](C)CCCCCCC2,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00006847_numbered.png,2026-03-19 06:55:05.777387
1390,ML00008194,,,CC1CCCC(O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 9]",ring_size_12/standard/numbered/ML00008194_numbered.png,2026-03-19 06:55:05.806233
1391,ML00007877,,,C=C1C(=O)OC2CCN3CC=C(COC(=O)C(C)(O)C(C)C1C)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1392,ML00002701,,,CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@H]3[C@@H]4C=C5C(=O)[C@H](C)[C@@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)CCC[C@H](C(C)C)OC(=O)C[C@H]5[C@@H]4C=C(C)[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_12/standard/numbered/ML00002701_numbered.png,2026-03-19 06:55:05.847931
1393,ML00000293,CHEMBL507308,PUNICAFOLIN,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@H]1OC(=O)c1cc(O)c(O)c(O)c1)[C@@H]2OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1394,ML00010605,,,O=C1CC/C=C/CCC(=O)N(Cc2cccc(C=NNC(=O)c3cccc(C(=O)NO)c3)c2)C[C@H](c2ccccc2)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1395,ML00006788,,,COc1ccc(C(=O)N[C@@H]2C(=O)NCC(=O)N[C@H](Cc3ccc(O)cc3)[C@@H](O)CC(=O)O[C@@H]2C)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1396,ML00009236,,,CO[C@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@H](C)O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cccc(OC(C)=O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1397,ML00002986,,,C=C1C[C@@]23OC(=O)C/C=C\[C@H]4[C@H]5[C@H](/C=C/CC)[C@H]5[C@H](c5cc(OC)c6c(c5)OCO6)[C@@H]4C(=O)OC[C@]2(C)[C@H]3[C@@H]2C=C(CO)C[C@@H]3C(=O)C(C)=C[C@H]3[C@@]12O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1398,ML00008421,,,C/C=C1/C[C@@H](COC(C)=O)[C@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1399,ML00009665,,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1400,ML00004603,,,CC(OC(=O)[C@@H](NC(=O)c1cc(O)c(O)c(C(=O)N[C@H]2COC(=O)[C@@H](NC(=O)c3cccc(O)c3O)COC(=O)[C@@H](NC(=O)c3cccc(O)c3O)COC2=O)c1)C(C)C)OC(=O)N1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1401,ML00008066,,,C[C@H]1CCCC/C=C\CCCC(=O)O1,standard_macrolactone,12.0,,,success,,1.0,[3],ring_size_12/standard/numbered/ML00008066_numbered.png,2026-03-19 06:55:05.929272
1402,ML00004055,,,O=C(O)C[C@]1(O)C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]1[C@H](O)C(=O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1403,ML00007948,,,C=C1C/C(=C\C)C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@@]1(C)O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1404,ML00010551,,,O=C(C[C@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@H]2CCCN2C1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1405,ML00001711,CHEMBL2152378,,CC(C)[C@@H]1COC(=O)[C@H](CC(=O)NCc2ccc(Cl)cc2)C/C=C/CCC(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1406,ML00008213,,,C[C@@H]1C[C@H](O)C/C=C\C(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 5, 9]",ring_size_12/standard/numbered/ML00008213_numbered.png,2026-03-19 06:55:05.985007
1407,ML00008772,,,CC[C@@H]1C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@@H](C)[C@H]1O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1408,ML00010865,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@@H]3CC[C@@H](C)[C@H](O)C[C@@](C)(CC/C=C/C=C/Br)OC(=O)C[C@](O)(C2)O3)[C@H](OC)[C@@H]1OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1409,ML00001120,CHEMBL1711599,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1410,ML00004040,,,O=C1C=C2C(=O)O[C@H]3[C@H](OC(=O)c4cc(O)c(O)c(O)c4)O[C@@H]4COC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)O[C@H]3[C@@H]4OC(=O)c3cc(O)c(O)c(O)c3[C@H]2C(=O)C1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1411,ML00009992,,,CCCCCCC[C@H]1OC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)CC)OC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1412,ML00006819,,,O=C(C[C@@H]1C/C=C\CCC(=O)OC[C@@H]2CCCN2C1=O)N[C@@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1413,ML00001577,CHEMBL1722114,,O=C(N[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)COC1=O)OCC1c2ccccc2-c2ccccc21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1414,ML00008607,,,C/C=C1/C[C@@H](CO)[C@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1415,ML00008663,,,C/C=C1/C[C@@H](C)[C@](C)(O)C(=O)OCC2=CCN3C[C@H](O)[C@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1416,ML00008924,,,O=C1OC[C@H](Cc2ccccc2)NC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\C[C@H]1Cc1ccc(F)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1417,ML00010310,,,CC[C@H]1O[C@]1(C)[C@H](O)[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/ML00010310_numbered.png,2026-03-19 06:55:06.093726
1418,ML00008199,,,C[C@H]1CCCC(O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,success,,3.0,"[3, 7, 9]",ring_size_12/standard/numbered/ML00008199_numbered.png,2026-03-19 06:55:06.123352
1419,ML00008775,,,C/C=C1\C(=O)O[C@@H]2CCN3CC[C@H](COC(=O)[C@@](C)(O)[C@@H](C)[C@@H]1O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1420,ML00010507,,,O=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1421,ML00007198,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1422,ML00002003,CHEMBL1710668,,O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1423,ML00007370,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](OC(=O)CCCC(=O)NCCCCCCO)C[C@H]2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00007370_numbered.png,2026-03-19 06:55:06.174619
1424,ML00002708,,,CO[C@@H]1[C@H](O[C@H]2[C@H](OC)CO[C@@H](O[C@H]3C[C@H]4CC(=O)[C@@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)[C@@H]2OC)O[C@@H](C)[C@@H](O)[C@@H]1OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1425,ML00007206,,,CCCCC(C)CC1NC(=O)C(C)NC(=O)C(Cc2ccccc2)NC(=O)CC(C(C)C)OC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1426,ML00006699,,,C[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C\C[C@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1427,ML00004153,,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)C(C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([N+](C)(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1428,ML00010043,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)N[C@H](C)C(C)=O)[C@@H](C)OC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1429,ML00007775,,,CO[C@@H]1/C=C/C(=O)O[C@@H](C)CCC/C=C\[C@@H]2C[C@H](O)C[C@H]21,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00007775_numbered.png,2026-03-19 06:55:06.235343
1430,ML00007020,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([Se]c2ccccc2)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00007020_numbered.png,2026-03-19 06:55:06.266647
1431,ML00008035,,,O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCCCO1,standard_macrolactone,13.0,,,success,,1.0,[11],ring_size_13/standard/numbered/ML00008035_numbered.png,2026-03-19 06:55:06.298705
1432,ML00008922,,,O=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1433,ML00010091,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1434,ML00003696,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1435,ML00010446,,,COc1ccc(C[C@H]2NC(=O)[C@]34OC(=O)O/C=C\[C@](C)(O)C(=O)[C@H](C)C/C=C\[C@@H]3[C@@H](O)C(C)=C(C)[C@H]24)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1436,ML00005335,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1437,ML00001889,CHEMBL383015,RADANAMYCIN,COc1c(O)cc2c(O)c1CC(C)OC(=O)c1c(O)cc(O)c(Cl)c1CCC(=O)N2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1438,ML00005336,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1439,ML00008253,,,C[C@H]1CCC/C=C\[C@@H]2CC(=O)C[C@H]2[C@H](O)/C=C\C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008253_numbered.png,2026-03-19 06:55:06.381786
1440,ML00005216,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1441,ML00002237,,,C/C=C1\CC(c2cc(CO)cc(NCC(O)C3CCCCC3)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00002237_numbered.png,2026-03-19 06:55:06.425906
1442,ML00007197,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1443,ML00008025,,,O=C1CCC/C=C\CCOC(=O)c2c(O)cc(O)c(Cl)c2C1,standard_macrolactone,13.0,,,success,,1.0,[10],ring_size_13/standard/numbered/ML00008025_numbered.png,2026-03-19 06:55:06.456908
1444,ML00010505,,,O=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1445,ML00001877,CHEMBL1079179,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)/C=C\[C@H](C)[C@H](C)OC2=O,standard_macrolactone,13.0,,,success,,4.0,"[3, 4, 7, 8]",ring_size_13/standard/numbered/ML00001877_numbered.png,2026-03-19 06:55:06.500225
1446,ML00003513,,,CC(C)CCCCCCCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H]1COC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)[C@@H](C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1447,ML00006700,,,COc1ccc(S[C@@H]2CC(=O)O[C@@H](C)CCC/C=C/[C@@H]3C[C@H](O)C[C@H]3[C@@H]2O)cc1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00006700_numbered.png,2026-03-19 06:55:06.537413
1448,ML00007875,,,C/C1=C/C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@H](C)C1)[C@H]23,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1449,ML00009519,,,CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H]([C@H](C)O)[C@@](C)(O)[C@H](O)[C@@H](C)C3=C(C)C[C@@]2(C)O3)[C@@H]1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1450,ML00008087,,,C[C@@H]1C/C(CO)=C\CC(=O)O[C@H](C)C/C=C\C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1451,ML00008554,,,CC(=O)O[C@@H]1/C=C/C(=O)O[C@@H](C)CCC/C=C\[C@@H]2C[C@H](O)C[C@H]21,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008554_numbered.png,2026-03-19 06:55:06.583692
1452,ML00010668,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1453,ML00002236,,,C/C=C1\CC(c2cc(CO)cc(NCC(C)(O)CCOC)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00002236_numbered.png,2026-03-19 06:55:06.622980
1454,ML00010663,,,CCCC[C@H](C)[C@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1455,ML00010680,,,CC(C)(C)[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1456,ML00008331,,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)/C=C\[C@H](C)[C@@H](C)OC2=O,standard_macrolactone,13.0,,,success,,4.0,"[3, 4, 7, 8]",ring_size_13/standard/numbered/ML00008331_numbered.png,2026-03-19 06:55:06.668490
1457,ML00002502,,,C/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCC3CCC4CC(=O)CC3C42)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00002502_numbered.png,2026-03-19 06:55:06.701532
1458,ML00010981,,,CC(C)CCC[C@H]1CC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1459,ML00008147,,,C[C@H]1CCC/C=C\[C@@H]2C[C@@H](O)C[C@H]2[C@H](O)/C=C\C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008147_numbered.png,2026-03-19 06:55:06.734147
1460,ML00002254,,,CCNCC/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00002254_numbered.png,2026-03-19 06:55:06.767512
1461,ML00010924,,,CCCCCC(CC(=O)N1N=CCCC1C(=O)N[C@H]1COC(=O)[C@H]2CCCNN2C(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)NC1=O)C(=O)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1462,ML00000138,CHEMBL26966,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1463,ML00008862,,,CCCCCC[C@H](C)[C@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1464,ML00004152,,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)C(C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([N+](C)(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1465,ML00008440,,,CC1CCCC=CC2CC(OC(=O)CN(C)C)CC2C(O)C=CC(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008440_numbered.png,2026-03-19 06:55:06.824471
1466,ML00006716,,,Nc1ccc(CC[C@H]2CCC/C=C/[C@@H]3C[C@H](O)C[C@H]3[C@H](O)/C=C/C(=O)O2)cc1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00006716_numbered.png,2026-03-19 06:55:06.851651
1467,ML00010993,,,CCCCCC[C@@H](C)[C@@H]1OC(=O)[C@H](CO)NC(=O)[C@H](C(=O)c2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1468,ML00000997,CHEMBL1087150,,O=C(C[C@H]1C/C=C/CCCC(=O)O[C@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1469,ML00005386,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC/N=C(\N(C)C)N2CCOCC2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1470,ML00005381,,,CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1471,ML00007295,,,O=C1CCC/C=C/C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1472,ML00010426,,,COc1ccc(C[C@H]2NC(=O)[C@]34OC(=O)O/C=C\[C@@](C)(O)C(=O)[C@@H](C)C/C=C\[C@H]3[C@H]3O[C@@]3(C)[C@@H](C)[C@H]24)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1473,ML00009533,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@](C)(O)C[C@@H](C)C2=C(C)C(=O)[C@@]1(C)O2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1474,ML00010144,,,C[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1475,ML00007305,,,O=C(C[C@H]1C/C=C/CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H](c2ccccc2)NC1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1476,ML00003365,,,C/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00003365_numbered.png,2026-03-19 06:55:06.955434
1477,ML00003704,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)C[C@H](C)[C@H](O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1478,ML00007882,,,C/C1=C/C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@H](C)C1)[C@H]23,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1479,ML00000025,CHEMBL1987060,,CC1CCC/C=C/C2CC(O)CC2C(O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00000025_numbered.png,2026-03-19 06:55:07.001531
1480,ML00005364,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1481,ML00002267,,,C/C=C1\CC(c2cc(CO)c(CCCCC)c(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00002267_numbered.png,2026-03-19 06:55:07.049168
1482,ML00009781,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1483,ML00007005,,,CC(=O)C[C@H](O)CC(=O)[C@@H]1OC(=O)CCCCCCCCc2ccccc21,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00007005_numbered.png,2026-03-19 06:55:07.079390
1484,ML00006815,,,COC(=O)c1ccccc1S[C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00006815_numbered.png,2026-03-19 06:55:07.110995
1485,ML00007019,,,C=C1/C=C\[C@@H]([C@H](C)C(=C)C)OC(=O)C[C@]2(O)O[C@@H](CC(=C)[C@H]2C)[C@@H]2O[C@H]2C1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1486,ML00008920,,,O=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1487,ML00008861,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C[C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1488,ML00010172,,,C[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1489,ML00006684,,,CCCCCCCCO[C@H]1O[C@@H]2COC(=O)CCCCCCC(=O)O[C@H]2[C@H](O)[C@H]1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1490,ML00002095,CHEMBL327709,,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CNC(=O)CCCOC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1491,ML00008570,,,CCC1CC(C)C(O)(CO)C(=O)OCC2=CCN3CC(CC23)OC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1492,ML00006774,,,O=C1CCC/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@@H]2CO1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1493,ML00006947,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])CCN(C)C)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00006947_numbered.png,2026-03-19 06:55:07.194487
1494,ML00001967,CHEMBL1933479,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](CO)C(=O)N[C@H](C2CCCCC2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1495,ML00008553,,,CC(=O)O[C@H]1C[C@H]2/C=C/CCC[C@H](C)OC(=O)/C=C/[C@@H](O)[C@@H]2C1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008553_numbered.png,2026-03-19 06:55:07.227751
1496,ML00000996,CHEMBL1088172,,O=C(C[C@@H]1C/C=C/CCCC(=O)O[C@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1497,ML00002062,CHEMBL4087980,,COC(=O)Nc1ccc2c(c1)NC(=O)OC/C=C/C[C@H](NC(=O)/C=C/c1cc(Cl)ccc1-n1cnnn1)c1nc-2c[nH]1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1498,ML00006793,,,CCCCCCCCO[C@H]1O[C@@H]2COC(=O)CC/C=C/CCC(=O)O[C@H]2[C@H](OC)[C@H]1OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1499,ML00005349,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1500,ML00001374,CHEMBL2158215,,CCCCCCCCCCCCC[C@H]1OC(=O)[C@H](COCc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1501,ML00002063,CHEMBL4082071,,COC(=O)Nc1ccc2c(c1)NC(=O)OCCCC[C@H](NC(=O)/C=C/c1cc(Cl)ccc1-n1cnnn1)c1nc-2c[nH]1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1502,ML00007194,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1503,ML00007202,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H](CC(C)C)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1504,ML00009241,,,NC(=O)C[C@H]1NC(=O)[C@H](CCCN(O)C=O)NC(=O)[C@H](NC(=O)C[C@H](O)[C@@H](N)CCCCNC(=O)c2cccc(O)c2O)COC(=O)[C@H](CCCN(O)C=O)NC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1505,ML00003697,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1506,ML00007713,,,C[C@@H]1C[C@H](O)[C@@H]2C=C[C@H](CC(=O)Cc3c(Cl)c(O)cc(O)c3C(=O)O1)O2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1507,ML00007193,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1508,ML00010501,,,O=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1509,ML00003233,,,CC(C)CC/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00003233_numbered.png,2026-03-19 06:55:07.354519
1510,ML00002005,CHEMBL1717692,,O=C1NC[C@@H](c2ccccc2)OC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1511,ML00008222,,,CC1CCC/C=C/C2CC(=O)CC2C(O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008222_numbered.png,2026-03-19 06:55:07.386611
1512,ML00001750,CHEMBL1081726,,O=C(C[C@H]1C/C=C/CCCC(=O)O[C@@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1513,ML00008512,,,CC/C=C\C[C@H]1/C=C\[C@H]2C=CC(=O)[C@@H]2C/C=C\CCCC(=O)O1,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00008512_numbered.png,2026-03-19 06:55:07.414749
1514,ML00006665,,,O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCC[C@H](CCc2ccc(F)cc2)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00006665_numbered.png,2026-03-19 06:55:07.440609
1515,ML00001140,CHEMBL1715575,,O=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)O[C@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1516,ML00010657,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1517,ML00007287,,,CC1=C2[C@H](Cc3ccccc3)NC(=O)[C@]23OC(=O)O/C=C\[C@](C)(O)C(=O)[C@H](C)C/C=C\[C@@H]3[C@H](O)[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1518,ML00000121,CHEMBL300004,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1519,ML00003821,,,C=CC[N+](C)(C)[C@@H]1C[C@@H](C)O[C@@H](O[C@@H]2C(C)C(O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@@H](C)O3)C(C)C(=O)OC(CC)[C@@](C)(O)[C@H](O)[C@@H](C)C3=C(C)C[C@]2(C)O3)[C@@H]1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1520,ML00010479,,,O=C1CCC/C=C/C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)CO1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1521,ML00008881,,,O=C1O[C@@H](c2ccccc2)CNC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C/CC[C@H]1Cc1ccc(F)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1522,ML00003705,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CCO)[C@H]2O)[C@@]2(C)C[C@H](C)[C@H](O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1523,ML00008302,,,CC(C)(C)[C@H]1COC(=O)CCC/C=C/C[C@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1524,ML00008306,,,C[C@H](O)C[S+]([O-])[C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00008306_numbered.png,2026-03-19 06:55:07.535541
1525,ML00004154,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@]2(C)C[C@H](C)[C@H](O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1526,ML00004586,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1527,ML00002483,,,C/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)C3(CCCC3)C2)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00002483_numbered.png,2026-03-19 06:55:07.585329
1528,ML00006876,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](OC(=O)CCCC(=O)O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00006876_numbered.png,2026-03-19 06:55:07.612337
1529,ML00006894,,,C=C(C)[C@@H](C)[C@@H]1/C=C\C(=O)C[C@@H]2O[C@H]2[C@@H]2CC(=C)[C@@H](C)[C@](O)(CC(=O)O1)O2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1530,ML00005003,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1531,ML00010425,,,COc1ccc(C[C@@H]2NC(=O)[C@@]34OC(=O)O/C=C\[C@@](C)(O)C(=O)[C@H](C)C/C=C\[C@H]3[C@@H]3O[C@]3(C)[C@@H](C)[C@@H]24)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1532,ML00007372,,,CCCCC[C@@H]1CC[C@H](C)CCCCC(=O)N(C)[C@@H](Cc2ccc(OCCO)cc2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1533,ML00005767,,,CO[C@@H]1[C@H](O[C@@H]2[C@H](OC)CO[C@@H](O[C@@H]3C[C@@H]4CC(=O)[C@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)[C@@H]2OC)O[C@@H](C)[C@@H](OC)[C@@H]1OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1534,ML00001233,CHEMBL1778156,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1535,ML00008299,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](SCC(N)C(=O)O)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00008299_numbered.png,2026-03-19 06:55:07.689344
1536,ML00003185,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC)[C@@H](C)OC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1537,ML00007077,,,CCCCC[C@]1(C)/C=C\C2[C@H](O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 3]",ring_size_13/standard/numbered/ML00007077_numbered.png,2026-03-19 06:55:07.723616
1538,ML00001894,CHEMBL1082035,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)/C=C\[C@@H](CC(F)(F)F)[C@H](C)OC2=O,standard_macrolactone,13.0,,,success,,4.0,"[3, 4, 7, 8]",ring_size_13/standard/numbered/ML00001894_numbered.png,2026-03-19 06:55:07.772743
1539,ML00005337,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1540,ML00008291,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])CCCO)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00008291_numbered.png,2026-03-19 06:55:07.813824
1541,ML00006936,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](SCCCCO)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00006936_numbered.png,2026-03-19 06:55:07.844024
1542,ML00009926,,,CCCCCC[C@H](C)[C@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H](CC(C)C)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1543,ML00010044,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)N[C@@H](C)C(C)=O)[C@@H](C)OC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1544,ML00010678,,,CC(C)(C)[C@H]1COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1545,ML00003701,,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)C(C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([N+](C)(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1546,ML00000709,CHEMBL262052,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1547,ML00007007,,,CC(=O)C[C@H](O)CC(=O)[C@H]1OC(=O)CCCCCCCCc2ccccc21,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00007007_numbered.png,2026-03-19 06:55:07.905943
1548,ML00003830,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1549,ML00005350,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1550,ML00008546,,,CC1=CC(=O)OC2CCN3CCC(COC(=O)C(C)(O)C(C)C1)C23,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1551,ML00003236,,,C/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3C2CCC(=O)C32CCCC2)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00003236_numbered.png,2026-03-19 06:55:07.968769
1552,ML00002275,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCc2cn(CC(=O)O)nn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1553,ML00001803,CHEMBL3355001,,O=C1OCCOc2cc(F)ccc2Nc2ncnc3[nH]c4c(c23)CC1CC4,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1554,ML00010288,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](C[C@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1555,ML00009324,,,COc1cc(/C=C2/C(=O)OC[C@H]3O[C@H](O[C@]4(CO)O[C@H](CO)[C@@H](O)[C@@H]4OC(=O)/C2=C/c2cc(OC)c(O)c(OC)c2)[C@H](O)[C@@H](O)[C@H]3O)cc(OC)c1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1556,ML00008173,,,O=C1OC[C@@]2(O)CO[C@@H](O[C@H]3[C@@H](OC[C@@H](O)[C@@H]3O)Oc3ccc(O)c1c3)[C@@H]2O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1557,ML00006658,,,O=C1CCC/C=C\C[C@H]2C(=O)C[C@@H](O)C2/C=C\[C@@H](CCc2ccccc2)O1,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00006658_numbered.png,2026-03-19 06:55:08.029354
1558,ML00005390,,,CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1559,ML00000619,CHEMBL2371731,,CCCCC(C)C1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1560,ML00006542,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCc2cn(Cc3ccccc3)nn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1561,ML00008930,,,O=C1OC[C@H](c2ccccc2)NC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C/CC[C@H]1Cc1ccc(F)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1562,ML00005290,,,CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1563,ML00001989,CHEMBL1933480,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C2=N[C@H](CO2)C(=O)N[C@H](C2CCCCC2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1564,ML00003904,,,C#CCO[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@](C)(OC(=O)C(C)C)[C@@H](CC)OC(=O)[C@@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1565,ML00007301,,,CC1=C[C@H]2/C=C\C[C@@H](C)C(=O)[C@H](C)/C=C\OC(=O)O[C@@]23C(=O)N[C@H](Cc2ccccc2)[C@H]3[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1566,ML00000826,CHEMBL338024,,CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)N[C@H]1COC(=O)CCC(CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1567,ML00006954,,,COC(=O)CC[S+]([O-])[C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00006954_numbered.png,2026-03-19 06:55:08.129675
1568,ML00004084,,,C/C=C1\CC(c2cc(CO)cc(CC(O)C(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00004084_numbered.png,2026-03-19 06:55:08.161972
1569,ML00010367,,,COc1ccc(C[C@H]2NC(=O)[C@]34OC(=O)O/C=C\[C@](C)(O)C(=O)[C@H](C)C/C=C\[C@@H]3[C@@H](O)[C@@](C)(O)[C@H](C)[C@H]24)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1570,ML00007045,,,CCCCC[C@H]1/C=C\[C@H]2[C@H](OC(C)=O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O1,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00007045_numbered.png,2026-03-19 06:55:08.192042
1571,ML00008621,,,C/C1=C/C(=O)O[C@@H]2CC[N+]3([O-])CC=C(COC(=O)[C@](C)(O)[C@H](C)C1)[C@H]23,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1572,ML00005006,,,CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1573,ML00007289,,,CC1=C(C)[C@H]2[C@H](Cc3ccccc3)NC(=O)[C@]23OC(=O)O/C=C/[C@@](C)(O)C(=O)[C@@H](C)C/C=C/[C@H]3[C@@H]1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1574,ML00007121,,,O=C1CCC/C=C\C[C@@H]2C(/C=C\[C@@H](COc3ccccc3)O1)[C@H](O)C[C@@H]2O,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00007121_numbered.png,2026-03-19 06:55:08.239988
1575,ML00010424,,,O=C1NCCOC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1576,ML00007009,,,CC/C=C\C[C@H]1/C=C\[C@H]2[C@H](OC(C)=O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O1,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00007009_numbered.png,2026-03-19 06:55:08.270311
1577,ML00010667,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1578,ML00007283,,,CC1=C(C)[C@@H]2[C@H](Cc3ccccc3)NC(=O)[C@]23OC(=O)O/C=C\[C@@](C)(O)C(=O)[C@@H](C)C/C=C\[C@H]3[C@H]1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1579,ML00005753,,,CO[C@@H]1[C@H](O[C@H]2[C@H](OC)CO[C@@H](O[C@H]3C[C@H]4CC(=O)[C@@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C=C/C5CCCCC5)OC(=O)C[C@H](O4)[C@@H]3C)[C@@H]2OC)O[C@@H](C)[C@@H](O)[C@@H]1OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1580,ML00010928,,,CCCCCC[C@H](C)[C@H]1CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1581,ML00005458,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC)[C@@H](C)CC)[C@H](C)CC)[C@@H](C)CC)[C@H](C)OC(=O)[C@H]([C@@H](C)CC)NC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1582,ML00010484,,,O=C1OC[C@H]2CCCN2C(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\CC[C@@H]1Cc1ccc(F)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1583,ML00006773,,,O=C1CCC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@H]2CO1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1584,ML00009942,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C[C@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1585,ML00010925,,,CCCCC[C@@H](CC(=O)N1N=CCC[C@@H]1C(=O)N[C@H]1COC(=O)[C@H]2CCCNN2C(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)NC1=O)C(=O)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1586,ML00007123,,,CC(=O)C[C@H](O)CC(=O)[C@H]1OC(=O)CCCCC/C=C/Cc2ccccc21,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00007123_numbered.png,2026-03-19 06:55:08.360010
1587,ML00009936,,,CCCCCC[C@H](C)[C@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1588,ML00007823,,,O=C1OCCOc2ncc(F)cc2[C@H]2CCCN2c2ccn3ncc1c3n2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1589,ML00002833,,,C/C=C1\CC(c2cc(CO)c(CCCCC)c(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00002833_numbered.png,2026-03-19 06:55:08.404989
1590,ML00003339,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([N+](C)(C)C)C2O)[C@]2(C)C[C@@H](C)C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1591,ML00010173,,,C[C@H]1COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1592,ML00004914,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N2C[C@@H](N)C[C@H]2C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1593,ML00006655,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccccc2)[C@@H](C)OC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1594,ML00010506,,,O=C(C[C@@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)OC[C@@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1595,ML00000134,CHEMBL27424,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1596,ML00002496,,,C/C=C1\CC(c2ccc(CCCCC)c(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00002496_numbered.png,2026-03-19 06:55:08.482421
1597,ML00008805,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](SCC(=O)O)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00008805_numbered.png,2026-03-19 06:55:08.512973
1598,ML00007307,,,O=C(C[C@H]1C/C=C/CC[C@@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1599,ML00008748,,,O=C(C[C@@H]1C/C=C\CCCC(=O)OC[C@@H]2CCCN2C1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1600,ML00007296,,,O=C1CCC/C=C/C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1601,ML00009255,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](C[C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1602,ML00005198,,,CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(C)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1603,ML00003726,,,CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H]([C@H](C)O)[C@@](C)(O)[C@H](O)[C@@H](C)C3=C(C)C[C@@]2(C)O3)[C@@H]1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1604,ML00009374,,,CCCCCC[C@H](C)[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]([C@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1605,ML00001369,CHEMBL65918,,CC(C)(C)S(=O)(=O)C[C@@H](Cc1ccccc1)C(=O)NC1CSCCC[C@H](CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1606,ML00001367,CHEMBL264636,,CC(C)(C)CC1CCC(=O)OC[C@H](NC(=O)C(Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC2CCCCC2)[C@@H](O)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1607,ML00002096,CHEMBL431854,,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCC(=O)NCCOC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1608,ML00004182,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C(C)C)[C@H]3O)[C@@]3(C)CC(C)=C(O3)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H]([C@H](C)O)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1609,ML00008459,,,CCCCC[C@@H]1/C=C\C2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O1,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00008459_numbered.png,2026-03-19 06:55:08.613921
1610,ML00009937,,,CCCC[C@H](C)[C@H]1CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1611,ML00002030,CHEMBL1597050,,C[C@H]1C/C=C/[C@@H]2[C@@H]3O[C@]3(C)[C@@H](C)[C@H]3[C@H](Cc4ccccc4)NC(=O)[C@]32OC(=O)O/C=C/[C@](C)(O)C1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1612,ML00000139,CHEMBL265495,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1613,ML00008755,,,CO[C@H]1C[C@H]2/C=C\CCC[C@H](C)OC(=O)/C=C/[C@@H](OC)[C@@H]2C1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008755_numbered.png,2026-03-19 06:55:08.660325
1614,ML00009509,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1615,ML00008252,,,C[C@@H]1CCC/C=C\[C@H]2CC(=O)C[C@@H]2[C@@H](O)/C=C\C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008252_numbered.png,2026-03-19 06:55:08.694027
1616,ML00006692,,,C[C@@H]1COC(=O)CCC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1617,ML00007203,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1618,ML00008086,,,C[C@H]1C[C@@H](CO)/C=C\C(=O)O[C@H](C)C/C=C\C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1619,ML00009257,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CC(C)C)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1620,ML00008548,,,C/C1=C/C(=O)O[C@@H]2CCN3CC[C@H](COC(=O)[C@](C)(O)[C@H](C)C1)[C@@H]23,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1621,ML00004987,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1622,ML00008297,,,COC(=O)CS(=O)(=O)[C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00008297_numbered.png,2026-03-19 06:55:08.767586
1623,ML00008145,,,C[C@@H]1CCC/C=C\[C@H]2C[C@@H](O)C[C@@H]2[C@@H](O)/C=C\C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008145_numbered.png,2026-03-19 06:55:08.796505
1624,ML00002387,,,CO[C@@H]1[C@@H](OC)[C@H](O[C@H]2[C@H](OC)[C@H](O[C@@H]3C[C@@H]4CC(=O)[C@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)OC[C@H]2O)O[C@H](C)[C@H]1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1625,ML00008185,,,C[C@H]1CCC/C=C/C2C[C@H](O)CC2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008185_numbered.png,2026-03-19 06:55:08.831829
1626,ML00007200,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1627,ML00008224,,,C[C@H]1CCC/C=C\[C@H]2CCC[C@H]2[C@H](O)/C=C\C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008224_numbered.png,2026-03-19 06:55:08.865884
1628,ML00002257,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(C)=O)[C@@H](C)OC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1629,ML00000705,CHEMBL297168,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1630,ML00000367,CHEMBL1714012,,O=C(C[C@@H]1C/C=C/CC[C@@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1631,ML00009834,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1632,ML00008921,,,O=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)N[C@@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1633,ML00006721,,,C[C@@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1634,ML00006941,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])CCCCO)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00006941_numbered.png,2026-03-19 06:55:08.940979
1635,ML00007286,,,C[C@H]1C/C=C\[C@H]2[C@@H]3O[C@]3(C)[C@@H](C)[C@H]3[C@H](Cc4ccccc4)NC(=O)[C@@]23OC(=O)O/C=C\[C@@](C)(O)C1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1636,ML00010821,,,O=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](Cc2c[nH]c3ccccc23)NC1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1637,ML00003707,,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)C(C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1638,ML00010094,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1639,ML00001083,CHEMBL1669774,,CC(=O)Oc1cc2c(c(OC(C)=O)c1)C(=O)OCCCCCCCCC2,standard_macrolactone,13.0,,,success,,0.0,[],ring_size_13/standard/numbered/ML00001083_numbered.png,2026-03-19 06:55:08.988243
1640,ML00005453,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1641,ML00008452,,,CCCCC[C@@H]1/C=C\C2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O1,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00008452_numbered.png,2026-03-19 06:55:09.020284
1642,ML00000137,CHEMBL1628277,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1643,ML00000704,CHEMBL289955,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1644,ML00006946,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](SCCN(C)C)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00006946_numbered.png,2026-03-19 06:55:09.066147
1645,ML00005424,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1646,ML00010287,,,CCCCC(C)C1CC(=O)NC(Cc2ccccc2)C(=O)NC(C)C(=O)NC(C(C)(C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1647,ML00010807,,,O=C1CCC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)CO1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1648,ML00007070,,,COC(=O)CCCC(=O)O[C@@H]1/C=C/C(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]21,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00007070_numbered.png,2026-03-19 06:55:09.116100
1649,ML00002388,,,CO[C@@H]1[C@@H](O[C@H]2C[C@H]3CC(=O)[C@]4(O)O[C@@H](C[C@@H]4C)C(C)(C)[C@H](/C=C/C=C/C=C/C(C)C)OC(=O)C[C@H](O3)[C@@H]2C)OC[C@H](O)[C@H]1O[C@H]1O[C@@H](C)[C@H](O)[C@@H](OC)[C@@H]1OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1650,ML00007073,,,O=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)OCCNC1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1651,ML00007290,,,CC1=C(C)[C@H]2[C@H](Cc3ccccc3)NC(=O)[C@]23OC(=O)O/C=C\[C@@](C)(O)C(=O)[C@@H](C)C/C=C\[C@H]3[C@@H]1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1652,ML00008659,,,C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3C[C@H](OC1=O)[C@H](O)[C@H]23,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1653,ML00006638,,,CO[C@H]1C(=O)OC[C@H](O)c2ccc3c(c2Cl)[C@@]24O[C@]5(O)C(=C(C)C(=O)[C@]16O[C@@H]56)O[C@@]2([C@H](O)C[C@H]4O)[C@@H]3O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1654,ML00005283,,,CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(N)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1655,ML00005208,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC)[C@@H](C)CC)[C@H](C)CC)[C@@H](C)CC)[C@H](C)OC(=O)[C@H]([C@@H](C)CC)NC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1656,ML00007004,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])c2ccc(O)cc2)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00007004_numbered.png,2026-03-19 06:55:09.201791
1657,ML00002652,,,CO[C@H]1[C@H](C)O[C@H](O[C@@H]2[C@@H](O)CO[C@H](O[C@H]3C[C@H]4CC(=O)[C@]5(O)O[C@@H](C[C@@H]5C)C(C)(C)[C@H](/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)[C@H]2OC)[C@@H](OC)[C@@H]1OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1658,ML00007565,,,O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OO[C@@H]([C@@H]2O)[C@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1659,ML00009833,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1660,ML00008932,,,O=C1N[C@@H](c2ccccc2)COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1661,ML00010307,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](C[C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1662,ML00000812,CHEMBL339673,,CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)N[C@H]1CCC(=O)OCC(CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1663,ML00005017,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1664,ML00009724,,,O=C1OC[C@H](Cc2ccccc2)NC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C/CC[C@H]1Cc1ccc(F)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1665,ML00006765,,,O=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1666,ML00005000,,,CCCc1ccc(-c2ccc(C[C@@H](N)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]3C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]3C)[C@@H](C)CC)[C@H](C)CC)[C@@H](C)CC)cc2)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1667,ML00006828,,,COc1ccc(CS[C@@H]2CC(=O)O[C@@H](C)CCC/C=C/[C@@H]3C[C@H](O)C[C@H]3[C@@H]2O)cc1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00006828_numbered.png,2026-03-19 06:55:09.309492
1668,ML00003867,,,C=CC[N+](C)(C)C1CC(C)OC(O[C@@H]2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)[C@@](C)(O)[C@H](O)[C@@H](C)C3O[C@@]2(C)C[C@H]3C)C1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1669,ML00002174,,,COC1C(O)C(C)OC(O[C@H]2C(OC)COC(O[C@H]3C[C@H]4CC(=O)[C@@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/c5ccccc5)OC(=O)C[C@H](O4)[C@@H]3C)[C@@H]2OC)[C@H]1OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1670,ML00010930,,,CCCCCCC(C)C1CC(=O)NC(C(C)C)C(=O)NC(Cc2ccccc2)C(=O)NC(C(C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1671,ML00008929,,,O=C1N[C@@H](c2ccccc2)COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1672,ML00002634,,,CO[C@@H]1[C@H](O[C@H]2[C@H](OC)CO[C@@H](O[C@H]3C[C@H]4CC(=O)[C@@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)[C@@H]2OC)O[C@@H](C)[C@@H](O)[C@@H]1OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1673,ML00010503,,,O=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1674,ML00002052,CHEMBL1438113,,CC(C)(C)[C@H]1COC(=O)CCC/C=C/C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1675,ML00009935,,,CCCCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1676,ML00007306,,,O=C(C[C@H]1C/C=C/CC[C@H](Cc2ccc(F)cc2)C(=O)O[C@H](c2ccccc2)CNC1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1677,ML00005192,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1678,ML00005768,,,CO[C@H]1[C@@H](OC)[C@H](OC)[C@@H](C)O[C@@H]1O[C@H]1[C@H](OC)[C@H](O[C@H]2C[C@H]3CC(=O)[C@]4(O)O[C@@H](C[C@@H]4C)C(C)(C)[C@H](/C=C/C=C/C=C/C(C)C)OC(=O)C[C@H](O3)[C@@H]2C)OC[C@H]1OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1679,ML00002488,,,CC(C)CC/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00002488_numbered.png,2026-03-19 06:55:09.420245
1680,ML00009729,,,O=C1N[C@@H](Cc2ccccc2)COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1681,ML00003364,,,CCNCC/C=C1\CC(c2cccc(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00003364_numbered.png,2026-03-19 06:55:09.459514
1682,ML00010500,,,O=C1OC[C@@H]2CCCN2C(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\CC[C@H]1Cc1ccc(F)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1683,ML00009516,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1684,ML00006076,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCc2cn(-c3cnc4ccccc4c3)nn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1685,ML00000016,CHEMBL19980,BREFELDIN A,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00000016_numbered.png,2026-03-19 06:55:09.507527
1686,ML00010929,,,CCCCCC[C@H](C)[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H]([C@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1687,ML00008517,,,COC(=O)[C@@]1(O)/C=C\C[C@H](C)OC(=O)c2c(O)cc(OC)cc2[C@H]2O[C@@H]2C[C@@H]1O,standard_macrolactone,13.0,,,success,,4.0,"[3, 7, 7, 8]",ring_size_13/standard/numbered/ML00008517_numbered.png,2026-03-19 06:55:09.546808
1688,ML00008301,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])CC(N)C(=O)O)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00008301_numbered.png,2026-03-19 06:55:09.578619
1689,ML00007116,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](Sc2ccc(Br)cc2)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00007116_numbered.png,2026-03-19 06:55:09.609654
1690,ML00003352,,,CC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC(C3(O)CCCC4CC(=O)CCC43)OC(=O)/C(=C/CO)C2)c1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00003352_numbered.png,2026-03-19 06:55:09.642120
1691,ML00005454,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1692,ML00006966,,,CCCCC[C@@H]1/C=C\C2[C@H](O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O1,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00006966_numbered.png,2026-03-19 06:55:09.675579
1693,ML00007014,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](Sc2ccc(N)cc2)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00007014_numbered.png,2026-03-19 06:55:09.705703
1694,ML00008142,,,C[C@H]1CCC[C@@H]2O[C@@H]2[C@@H]2C[C@H](O)C[C@H]2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008142_numbered.png,2026-03-19 06:55:09.731082
1695,ML00003820,,,C=CC[N+](C)(C)[C@@H]1C[C@@H](C)O[C@@H](O[C@@H]2C(C)C(O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@@H](C)O3)C(C)C(=O)OC(CC)[C@@](C)(O)[C@H](O)[C@@H](C)C3=C(C)C[C@]2(C)O3)[C@@H]1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1696,ML00008043,,,CCC[C@H]1CCCCCCCC(=O)OCCN1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1697,ML00007298,,,CC1CC=CC2C3OC3(C)C(C)C3C(Cc4ccccc4)NC(=O)C23OC(=O)OC=CC(C)(O)C1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1698,ML00010275,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CC(C)C)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1699,ML00010268,,,CCCCCCCCCCC(C)C1OC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(C(C)C)NC(=O)C1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1700,ML00006762,,,O=C(C[C@@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)OC[C@@H]2CCCN2C1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1701,ML00008400,,,CC(=O)O[C@H]1C[C@H]2/C=C\CCC[C@H](C)OC(=O)/C=C/[C@@H](OC(C)=O)[C@@H]2C1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008400_numbered.png,2026-03-19 06:55:09.796479
1702,ML00001502,CHEMBL4068515,,CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1703,ML00006701,,,COc1ccc([S+]([O-])[C@@H]2CC(=O)O[C@@H](C)CCC/C=C/[C@@H]3C[C@H](O)C[C@H]3[C@@H]2O)cc1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00006701_numbered.png,2026-03-19 06:55:09.837657
1704,ML00005207,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CN)C(=O)N[C@H]1C(=O)N[C@@H](CN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1705,ML00011005,,,CCCCC[C@@H](CC(=O)N1N=CCC[C@@H]1C(=O)N[C@H]1COC(=O)[C@H]2CCC=NN2C(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)NC1=O)C(=O)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1706,ML00010502,,,O=C(C[C@@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1707,ML00003069,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCc2cn(CCO)nn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1708,ML00008226,,,CC1CCC/C=C/C2CCCC2C(O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008226_numbered.png,2026-03-19 06:55:09.894818
1709,ML00010421,,,O=C1NCCOC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1710,ML00009514,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1711,ML00002707,,,CO[C@H]1[C@@H](O)[C@@H](C)O[C@H](O[C@H]2[C@H](OC)CO[C@@H](O[C@H]3C[C@H]4CC(=O)[C@]5(O)O[C@@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)[C@@H]2OC)[C@@H]1OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1712,ML00007196,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1713,ML00010137,,,CC[C@H]1OC(=O)[C@H](C)[C@@]2(O)O[C@@](C)(C[C@@H](C)/C(=N\O)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1714,ML00007069,,,COC(=O)CCCC(=O)O[C@H]1C[C@H]2/C=C/CCC[C@H](C)OC(=O)/C=C/[C@@H](O)[C@@H]2C1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00007069_numbered.png,2026-03-19 06:55:09.955685
1715,ML00005001,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1716,ML00007195,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1717,ML00003831,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1718,ML00003600,,,O=C1N[C@@H](Cc2c[nH]c3ccccc23)COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1719,ML00009193,,,CCCCCCCC[C@H](C)[C@H]1OC(=O)[C@@H](CO)NC(=O)[C@@H](C(=O)c2c[nH]c3ccccc23)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1720,ML00009927,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C[C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1721,ML00005033,,,CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(-c2ccc(-c3ccccc3)cc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1722,ML00008076,,,O=C1C/C=C\C/C=C\CCCCCO1,standard_macrolactone,13.0,,,success,,0.0,[],ring_size_13/standard/numbered/ML00008076_numbered.png,2026-03-19 06:55:10.029306
1723,ML00007601,,,O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCC[C@H](CCc2cccc3ccccc23)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00007601_numbered.png,2026-03-19 06:55:10.056122
1724,ML00010927,,,CC(C)C[C@H]1NC(=O)[C@@H](NC(=O)[C@@H]2CCC=NN2C(=O)C[C@@H](CCC[C@H](C)O)C(=O)O)COC(=O)[C@H]2CCCNN2C(=O)[C@H](C)NC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1725,ML00007122,,,CC(=O)C[C@@H](O)CC(=O)[C@@H]1OC(=O)CCCCC/C=C/Cc2ccccc21,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00007122_numbered.png,2026-03-19 06:55:10.087003
1726,ML00010419,,,O=C(C[C@@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](Cc2ccccc2)NC1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1727,ML00003730,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1728,ML00003727,,,CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CCO)[C@@](C)(O)[C@H](O)[C@@H](C)C3=C(C)C[C@@]2(C)O3)[C@@H]1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1729,ML00008996,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1730,ML00000645,CHEMBL1572153,,C[C@H]1CCC/C=C/C2C[C@H](O)C[C@H]2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00000645_numbered.png,2026-03-19 06:55:10.142315
1731,ML00004509,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CN)C(=O)N[C@H](CN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1732,ML00009492,,,C/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00009492_numbered.png,2026-03-19 06:55:10.187613
1733,ML00007036,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])c2cccc(N)c2)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00007036_numbered.png,2026-03-19 06:55:10.221805
1734,ML00000157,CHEMBL2373603,,C[C@H]1CCC/C=C/[C@@H]2C[C@@H](O)C[C@]2(O)C/C=C\C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 10]",ring_size_13/standard/numbered/ML00000157_numbered.png,2026-03-19 06:55:10.249506
1735,ML00007010,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](Sc2ccc(O)cc2)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00007010_numbered.png,2026-03-19 06:55:10.282246
1736,ML00000710,CHEMBL43313,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1737,ML00008915,,,CCCCCCCCCCCCC[C@H](O)[C@H](C)[C@H]1OC(=O)[C@@H](COC(C)=O)NC(=O)[C@@H]([C@H](C)OS(=O)(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1738,ML00004269,,,CC(C)CCCCCCCCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H]1COC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)[C@@H](C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1739,ML00008931,,,O=C1N[C@@H](c2ccccc2)COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1740,ML00008860,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C[C@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1741,ML00006631,,,O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCC[C@H](CCc2ccc(C(F)(F)F)cc2)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00006631_numbered.png,2026-03-19 06:55:10.352082
1742,ML00006978,,,O=C(C[C@@H]1C/C=C\CCCC(=O)OC[C@@H](c2ccccc2)NC1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1743,ML00008295,,,COC(=O)CS[C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00008295_numbered.png,2026-03-19 06:55:10.392766
1744,ML00006769,,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)/C=C\[C@@H](Cc1ccccc1)[C@H](C)OC2=O,standard_macrolactone,13.0,,,success,,4.0,"[3, 4, 7, 8]",ring_size_13/standard/numbered/ML00006769_numbered.png,2026-03-19 06:55:10.430079
1745,ML00003870,,,C#CC[N+](C)(C)[C@@H]1C[C@@H](C)O[C@@H](O[C@@H]2C(C)C(O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@@H](C)O3)C(C)C(=O)OC(CC)[C@@](C)(O)[C@H](O)[C@@H](C)C3=C(C)C[C@]2(C)O3)[C@@H]1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1746,ML00003602,,,C/C=C1\CC(c2cc(CO)cc(NCC)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00003602_numbered.png,2026-03-19 06:55:10.474610
1747,ML00008296,,,COC(=O)C[S+]([O-])[C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00008296_numbered.png,2026-03-19 06:55:10.508169
1748,ML00006897,,,C[C@@H]1[C@@H](O)C[C@H]2CC(=O)[C@@]3(O)O[C@H](C[C@H]3C)C(C)(C)[C@@H](/C=C/I)OC(=O)C[C@@H]1O2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1749,ML00003338,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([N+](C)(C)C)C2O)[C@]2(C)C[C@@H](C)C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1750,ML00009723,,,O=C1N[C@H](Cc2ccccc2)COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1751,ML00004510,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CN)C(=O)N[C@H]1C(=O)N[C@@H](CN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1752,ML00010677,,,CC(C)(C)[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1753,ML00001896,CHEMBL1076352,,O=C(C[C@@H]1C/C=C/CCCC(=O)OCCNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1754,ML00008144,,,C[C@H]1CCCC=CC2C[C@H](O)CC2[C@H](O)C=CC(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008144_numbered.png,2026-03-19 06:55:10.584152
1755,ML00005425,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1756,ML00006817,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](OC(=O)CCC(=O)O)C[C@H]2[C@H](OC(=O)CCC(=O)O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00006817_numbered.png,2026-03-19 06:55:10.623939
1757,ML00000474,CHEMBL1355410,,CCC1OC(=O)C(C)C(=O)C(C)[C@@H](OC2OC(C)CC(N(C)C)C2O)C(C)(OC)C2(CCCn3cnc(-c4cccnc4)c3)CC(C)C(=O)C(C)C3N(C2)C(=O)O[C@]13C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1758,ML00007809,,,C[C@H]1C/C=C\Cc2ccc(o2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1759,ML00007082,,,O=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)OCCNC1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1760,ML00006683,,,CCOP(=O)(CC[Se][C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1O)OCC,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00006683_numbered.png,2026-03-19 06:55:10.675902
1761,ML00009569,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)N=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1762,ML00010664,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H](CC(C)C)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1763,ML00005196,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1764,ML00008114,,,O=C1CCCCCCCCCCCO1,standard_macrolactone,13.0,,,success,,0.0,[],ring_size_13/standard/numbered/ML00008114_numbered.png,2026-03-19 06:55:10.720962
1765,ML00010090,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1766,ML00007292,,,C=C1[C@@H](C)[C@H]2[C@H](Cc3ccccc3)NC(=O)[C@]23OC(=O)O/C=C\[C@@](C)(O)C(=O)[C@@H](C)C/C=C\[C@H]3[C@@H]1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1767,ML00002653,,,CO[C@@H]1[C@H](O[C@@H]2C[C@@H]3CC(=O)[C@]4(O)O[C@H](C[C@H]4C)C(C)(C)[C@@H](/C=C/C=C/C(C)C)OC(=O)C[C@H](O3)[C@@H]2C)OC[C@@H](O)[C@H]1O[C@@H]1O[C@H](C)[C@@H](OC)[C@H](OC)[C@H]1OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1768,ML00005002,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1769,ML00007006,,,CC(=O)C[C@@H](O)CC(=O)[C@H]1OC(=O)CCCCCCCCc2ccccc21,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00007006_numbered.png,2026-03-19 06:55:10.775116
1770,ML00009857,,,CCCCCCCCO[C@H]1O[C@@H]2COC(=O)CC/C=C/CCC(=O)O[C@H]2[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1771,ML00008524,,,COc1cc(O)c2c(c1C)C(=O)O[C@H](CO)CC/C(S)=N/[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1772,ML00008186,,,CC1CCCC=CC2CC(O)CC2C(O)C=CC(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008186_numbered.png,2026-03-19 06:55:10.813167
1773,ML00008158,,,COc1cc(O)cc2c1C(=O)OO[C@@H](C)CCCCC/C=C\2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1774,ML00008080,,,O=C1CCCCCCCC(=O)OCCO1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1775,ML00000092,CHEMBL1701527,,O=C(C[C@@H]1C/C=C/CC[C@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](Cc2ccccc2)NC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1776,ML00001444,CHEMBL1933481,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](Cn2cc(CNC(=O)CCCCNC(=O)CCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)C(=O)N[C@H](C2CCCCC2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1777,ML00007714,,,C[C@@H]1CC(O)C2C=CC(CC(=O)Cc3c(Cl)c(O)cc(O)c3C(=O)O1)O2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1778,ML00008787,,,CCCCC[C@@H]1CCCCC[C@@H]2CC(=O)[C@H](CCC(=O)O1)O2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1779,ML00008673,,,COc1cc(O)c(Cl)c2c1C(=O)O[C@@H](C)CC[C@H]1CC[C@@H](CC(=O)C2)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1780,ML00000382,CHEMBL1736166,,O=C(C[C@@H]1C/C=C/CC[C@@H](Cc2ccc(F)cc2)C(=O)O[C@H](c2ccccc2)CNC1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1781,ML00001749,CHEMBL1080649,,O=C(C[C@@H]1C/C=C/CCCC(=O)O[C@@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1782,ML00010675,,,CC(C)(C)[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1783,ML00010308,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](C[C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1784,ML00000067,CHEMBL2373625,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@@H]2[C@H](O)/C=C\C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00000067_numbered.png,2026-03-19 06:55:10.909000
1785,ML00010368,,,COc1ccc(C[C@@H]2NC(=O)[C@@]34OC(=O)O/C=C/[C@@](C)(O)C(=O)[C@@H](C)C/C=C/[C@H]3[C@H](O)[C@](C)(O)[C@@H](C)[C@@H]24)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1786,ML00007841,,,COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OCCC/C(S)=N/1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1787,ML00007049,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)C[C@H]2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00007049_numbered.png,2026-03-19 06:55:10.953277
1788,ML00010418,,,O=C(C[C@@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](Cc2ccccc2)NC1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1789,ML00006862,,,CCCCCCCCO[C@H]1O[C@@H]2COC(=O)CC[C@H]3O[C@@H]3CCC(=O)O[C@H]2[C@H](O)[C@H]1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1790,ML00008441,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](OC(=O)CN(C)C)C[C@H]2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008441_numbered.png,2026-03-19 06:55:10.994395
1791,ML00006877,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](OC(=O)CCCC(=O)O)C[C@H]2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00006877_numbered.png,2026-03-19 06:55:11.020232
1792,ML00008453,,,CCCCC[C@H]1/C=C\[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O1,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00008453_numbered.png,2026-03-19 06:55:11.042530
1793,ML00005439,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCN=C(N(C)C)N(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1794,ML00000713,CHEMBL166642,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1795,ML00008949,,,CCCCCCCCCCCCC[C@H](O)[C@H](C)[C@H]1OC(=O)[C@H](COC(C)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1796,ML00006706,,,C[C@H]1COC(=O)CCC/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1797,ML00001790,CHEMBL1077390,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)/C=C\[C@@H](C)COC2=O,standard_macrolactone,13.0,,,success,,3.0,"[4, 7, 8]",ring_size_13/standard/numbered/ML00001790_numbered.png,2026-03-19 06:55:11.102184
1798,ML00007308,,,O=C(C[C@@H]1C/C=C/CC[C@H](Cc2ccc(F)cc2)C(=O)O[C@H](c2ccccc2)CNC1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1799,ML00005456,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC)[C@@H](C)CC)[C@H](C)CC)[C@@H](C)CC)[C@H](C)OC(=O)[C@H]([C@@H](C)CC)NC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1800,ML00001137,CHEMBL1368499,,O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1801,ML00004060,,,O=C(O)C[C@@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4cc(c(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1[C@H](O)C(=O)O3,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1802,ML00006035,,,CC[C@H](C)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1803,ML00010666,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1804,ML00007564,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)OO[C@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1805,ML00007410,,,O=C(OC1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)COC(C2O)C1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1806,ML00004738,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCc2cn(C34CC5CC(CC(C5)C3)C4)nn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1807,ML00009731,,,C/C=C1\CC(c2cc(CO)cc(NCC)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00009731_numbered.png,2026-03-19 06:55:11.208075
1808,ML00008305,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])C[C@@H](C)O)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00008305_numbered.png,2026-03-19 06:55:11.238860
1809,ML00005206,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1810,ML00009735,,,C/C=C1\CC(c2cccc(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00009735_numbered.png,2026-03-19 06:55:11.280856
1811,ML00009880,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(C)=O)[C@@H](C)OC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1812,ML00008052,,,O=C1CCCCCCC/C=C/CCO1,standard_macrolactone,13.0,,,success,,0.0,[],ring_size_13/standard/numbered/ML00008052_numbered.png,2026-03-19 06:55:11.307420
1813,ML00008149,,,CC1CCC/C=C/C2CC(O)CC2C(O)/C=C\C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008149_numbered.png,2026-03-19 06:55:11.332065
1814,ML00010670,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1815,ML00009835,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1816,ML00002045,CHEMBL1983653,,O=C1NCCOC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1817,ML00008399,,,CC(=O)O[C@H]1C[C@H]2/C=C/CCC[C@H](C)OC(=O)/C=C/[C@@H](OC(C)=O)[C@@H]2C1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008399_numbered.png,2026-03-19 06:55:11.379651
1818,ML00004219,,,CCCCCCCCCCCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H]1COC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)[C@@H](C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1819,ML00008148,,,C[C@H]1CCC/C=C\[C@@H]2C[C@H](O)C[C@H]2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008148_numbered.png,2026-03-19 06:55:11.411945
1820,ML00004098,,,C/C=C1\CC(c2cccc(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3C2CCC(=O)C32CCCC2)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00004098_numbered.png,2026-03-19 06:55:11.444621
1821,ML00007018,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])c2ccc(N)cc2)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00007018_numbered.png,2026-03-19 06:55:11.474800
1822,ML00005205,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1823,ML00010414,,,O=C(C[C@@H]1C/C=C/CC[C@@H](Cc2ccc(F)cc2)C(=O)OCCNC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1824,ML00007315,,,O=C(C[C@@H]1C/C=C/CCCC(=O)O[C@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1825,ML00007779,,,CC[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00007779_numbered.png,2026-03-19 06:55:11.523603
1826,ML00010175,,,C[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1827,ML00009493,,,CC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC(C(C)(O)C3CCC(=O)CC3)OC(=O)/C(=C/CO)C2)c1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00009493_numbered.png,2026-03-19 06:55:11.562072
1828,ML00003866,,,C=CC[N+](C)(C)C1CC(C)OC(O[C@@H]2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)[C@@](C)(O)[C@H](O)[C@@H](C)C3O[C@@]2(C)C[C@H]3C)C1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1829,ML00008157,,,COc1cc(O)cc2c1C(=O)OOC(C)CCCCC/C=C/2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1830,ML00008356,,,COc1cc(O)c2c(c1C)C(=O)OCCC/C(S)=N/[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1831,ML00005452,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1832,ML00008202,,,O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCC[C@H](C(F)(F)F)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008202_numbered.png,2026-03-19 06:55:11.618001
1833,ML00009323,,,COc1cc(/C=C2/C(=O)O[C@H]3[C@H](O)[C@@H](CO)O[C@@]3(CO)O[C@H]3O[C@H](COC(=O)/C2=C/c2cc(OC)c(O)c(OC)c2)[C@@H](O)[C@H](O)[C@H]3O)c(OC)cc1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1834,ML00002798,,,CO[C@@H]1[C@H](O[C@H]2[C@H](OC)CO[C@@H](O[C@H]3C[C@H]4CC(=O)[C@@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C#C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)[C@@H]2OC)O[C@@H](C)[C@@H](O)[C@@H]1OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1835,ML00008789,,,CCCCC[C@H]1CCCCC[C@H]2CC(=O)[C@@H](CCC(=O)O1)O2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1836,ML00002107,CHEMBL338764,,CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)N[C@H]1COC(=O)CCCOC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1837,ML00003347,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CCN)[C@H]2O)[C@@]2(C)C[C@H](C)[C@H](O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1838,ML00008054,,,O=C1C/C=C\CCCCCCCCO1,standard_macrolactone,13.0,,,success,,0.0,[],ring_size_13/standard/numbered/ML00008054_numbered.png,2026-03-19 06:55:11.672121
1839,ML00010669,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1840,ML00003404,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1841,ML00008786,,,CCCCC[C@@H]1CCCCC[C@@H]2CC(=O)[C@H](CCC(=O)O1)O2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1842,ML00003863,,,CCCCN(C)[C@H]1C[C@@H](C)OC(O[C@@H]2[C@@H](C)[C@H](OC3C[C@@](C)(OC)C[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)[C@H]3O[C@]2(C)C[C@@H]3C)[C@@H]1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1843,ML00008040,,,CC(=O)O[C@@H]1[C@@H]2C(=O)N1C(=O)CC/C=C/CCC(=O)O[C@@H]2C,non_standard_macrocycle,13.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
1844,ML00010499,,,O=C1OC[C@@H]2CCCN2C(=O)[C@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\CC[C@@H]1Cc1ccc(F)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1845,ML00005333,,,CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1846,ML00010997,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1847,ML00008413,,,CCCCC[C@@H]1/C=C\C2C=CC(=O)[C@@H]2C/C=C\CCCC(=O)O1,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00008413_numbered.png,2026-03-19 06:55:11.751946
1848,ML00008278,,,C[C@H]1C[C@@]2(C)O[C@H]2C(=O)O[C@H]2CCN(C)C/C=C(/COC(=O)[C@]1(C)O)C2=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1849,ML00009489,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1850,ML00000136,CHEMBL27419,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1851,ML00008658,,,C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3C[C@@H](OC1=O)[C@@H](O)[C@@H]23,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1852,ML00001131,CHEMBL331085,,CC(C)CC1CCC(=O)OC[C@H](NC(=O)C(Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC2CCCCC2)[C@@H](O)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1853,ML00003725,,,CC1=C2O[C@](C)(C1)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C(C)C)[C@H]1O)[C@@H](C)[C@H](O[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1)[C@@H](C)C(=O)O[C@H]([C@H](C)O)[C@@](C)(O)[C@H](O)[C@H]2C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1854,ML00006680,,,C/C=C/CNC(=N)NCCCCCCCCN1CCCCOC(=O)CCNC(=N)NC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1855,ML00007008,,,CC(=O)C[C@@H](O)CC(=O)[C@@H]1OC(=O)CCCCCCCCc2ccccc21,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00007008_numbered.png,2026-03-19 06:55:11.821620
1856,ML00008754,,,C[C@H]1CCC/C=C\[C@]2(C)C[C@H](O)C[C@@]2(C)[C@H](O)/C=C\C(=O)O1,standard_macrolactone,13.0,,,success,,4.0,"[3, 9, 10, 11]",ring_size_13/standard/numbered/ML00008754_numbered.png,2026-03-19 06:55:11.852413
1857,ML00008788,,,CCCCC[C@H]1CCCCC[C@H]2CC(=O)[C@@H](CCC(=O)O1)O2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1858,ML00007371,,,CCC[C@H](O)C[C@@H]1CC[C@H](C)CCCCC(=O)N(C)[C@@H](Cc2ccc(OCCO)cc2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1859,ML00001936,CHEMBL1357349,,O=C1OC[C@H]2CCCN2C(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\CC[C@H]1Cc1ccc(F)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1860,ML00003275,,,C/C=C1\CC(c2cc(NCC(C)O)cc(C(O)CNC)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00003275_numbered.png,2026-03-19 06:55:11.904083
1861,ML00008393,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](SCC(O)CO)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00008393_numbered.png,2026-03-19 06:55:11.933556
1862,ML00008451,,,CCCCC[C@@H]1/C=C\C2C(=O)CC(O)[C@@H]2C/C=C\CCCC(=O)O1,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00008451_numbered.png,2026-03-19 06:55:11.955708
1863,ML00008454,,,CC/C=C\C/C=C\C[C@@H]1OC(=O)CCC/C=C\C[C@H](O)/C=C\[C@H]1O,standard_macrolactone,13.0,,,success,,3.0,"[3, 4, 7]",ring_size_13/standard/numbered/ML00008454_numbered.png,2026-03-19 06:55:11.984089
1864,ML00006702,,,C[C@H]1COC(=O)[C@@H](N)CC/C=C/C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1865,ML00009725,,,O=C1OC[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C/CC[C@H]1Cc1ccc(F)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1866,ML00006977,,,O=C(C[C@@H]1C/C=C/CCCC(=O)O[C@H](c2ccccc2)CNC1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1867,ML00008104,,,C/C1=C/COc2ccc(cc2)/C=C\C(=O)OC1,non_standard_macrocycle,13.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
1868,ML00003834,,,C#CC[N+](C)(C)[C@@H]1C[C@@H](C)O[C@@H](O[C@@H]2C(C)C(O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@@H](C)O3)C(C)C(=O)OC(CC)[C@@](C)(O)[C@H](O)[C@@H](C)C3=C(C)C[C@]2(C)O3)[C@@H]1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1869,ML00008187,,,C[C@H]1CCCCC[C@@H]2CC(=O)CC2C(=O)CCC(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008187_numbered.png,2026-03-19 06:55:12.043139
1870,ML00008228,,,CC1(C)COC(=O)CCCOC(=O)C2CCCCN2C(=O)C1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1871,ML00006722,,,C[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1872,ML00009933,,,CCCCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H](CC(C)C)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1873,ML00007300,,,CC1=C[C@H]2/C=C\C[C@@H](C)C(=O)[C@@](C)(O)/C=C\OC(=O)O[C@]23C(=O)N[C@@H](Cc2ccc(O)cc2)[C@@H]3[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1874,ML00010427,,,COc1ccc(C[C@@H]2NC(=O)[C@@]34OC(=O)O/C=C\[C@@](C)(O)C(=O)[C@@H](C)C/C=C\[C@H]3[C@@H]3O[C@]3(C)[C@@H](C)[C@H]24)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1875,ML00001138,CHEMBL1733880,,O=C1NC[C@H](c2ccccc2)OC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1876,ML00003626,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)[C@@H]2O[C@]1(C)[C@@H](N)[C@H]2C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1877,ML00008146,,,C[C@H]1CCC/C=C\[C@@H]2C[C@H](O)C[C@H]2[C@H](O)/C=C\C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008146_numbered.png,2026-03-19 06:55:12.114707
1878,ML00008108,,,C[C@@H]1CCCCCCCCCCC(=O)O1,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00008108_numbered.png,2026-03-19 06:55:12.137074
1879,ML00007015,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](Sc2cccc(N)c2)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00007015_numbered.png,2026-03-19 06:55:12.166581
1880,ML00005210,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1881,ML00007288,,,CC1=C2[C@@H](Cc3ccccc3)NC(=O)[C@@]23OC(=O)O/C=C\[C@@](C)(O)C(=O)[C@@H](C)C/C=C\[C@H]3[C@H](O)[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1882,ML00008408,,,CC(=O)O[C@@]1(C)C(=O)OC[C@H]2CCN3CC[C@@H](OC(=O)/C=C(/C)C[C@H]1C)[C@@H]23,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1883,ML00003822,,,C#CC[N+](C)(C)C1CC(C)OC(O[C@@H]2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)[C@@](C)(O)[C@H](O)[C@@H](C)C3O[C@@]2(C)C[C@H]3C)C1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1884,ML00008298,,,COC(=O)CS(=O)(=O)[C@@H]1CC(=O)O[C@@H](C)CCCC2OC2[C@@H]2C[C@H](O)C[C@H]2[C@@H]1O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00008298_numbered.png,2026-03-19 06:55:12.227799
1885,ML00010423,,,O=C1OCCNC(=O)[C@@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C/CC[C@H]1Cc1ccc(F)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1886,ML00009256,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](C[C@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1887,ML00008141,,,O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCC[C@H](CO)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008141_numbered.png,2026-03-19 06:55:12.267894
1888,ML00008249,,,O=C1OCCCCCCCCCc2cc(O)cc(O)c21,standard_macrolactone,13.0,,,success,,0.0,[],ring_size_13/standard/numbered/ML00008249_numbered.png,2026-03-19 06:55:12.287944
1889,ML00010095,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1890,ML00003823,,,C#CC[N+](C)(C)C1CC(C)OC(O[C@@H]2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)[C@@](C)(O)[C@H](O)[C@@H](C)C3O[C@@]2(C)C[C@H]3C)C1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1891,ML00008948,,,CCCCCCCCCCCCC[C@H](O)[C@H](C)[C@H]1OC(=O)[C@@H](COC(C)=O)NC(=O)[C@@H]([C@H](C)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1892,ML00007285,,,C[C@H]1[C@H]2[C@H](Cc3ccccc3)NC(=O)[C@]23OC(=O)O/C=C\[C@@](C)(O)C(=O)[C@H](C)C/C=C\[C@H]3[C@@H]2O[C@]12C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1893,ML00008355,,,COc1cc(O)c2c(c1C)C(=O)OCCCC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1894,ML00007115,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])c2ccc(Br)cc2)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00007115_numbered.png,2026-03-19 06:55:12.350092
1895,ML00005044,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1896,ML00003599,,,C/C=C1\CC(c2cccc(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCC3CCC4CC(=O)CC3C42)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00003599_numbered.png,2026-03-19 06:55:12.393415
1897,ML00009733,,,C/C=C1\CC(c2cc(O)cc(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00009733_numbered.png,2026-03-19 06:55:12.425634
1898,ML00002690,,,CO[C@@H]1[C@@H](OC)[C@H](O[C@H]2[C@H](OC)[C@H](O[C@@H]3C[C@@H]4CC(=O)[C@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)OC[C@H]2OC(C)=O)O[C@H](C)[C@H]1OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1899,ML00003801,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1900,ML00006143,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1901,ML00007847,,,COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OCCCC(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1902,ML00008401,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](OC(=O)CCC(=O)O)C[C@H]2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008401_numbered.png,2026-03-19 06:55:12.481250
1903,ML00009923,,,CCCCCCCC[C@@H](C)[C@@H]1OC(=O)[C@H](CO)NC(=O)[C@H](C(=O)c2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1904,ML00002704,,,CO[C@@H]1[C@H](O[C@H]2[C@H](OC(C)=O)CO[C@@H](O[C@H]3C[C@H]4CC(=O)[C@@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)[C@@H]2OC)O[C@@H](C)[C@@H](OC)[C@@H]1OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1905,ML00007423,,,O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCC[C@H](CCc2ccc3cccnc3c2)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00007423_numbered.png,2026-03-19 06:55:12.522156
1906,ML00007114,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([Se]c2ccc(Cl)cc2)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00007114_numbered.png,2026-03-19 06:55:12.551856
1907,ML00006816,,,O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCC[C@H](CCOCc2ccccc2)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00006816_numbered.png,2026-03-19 06:55:12.577967
1908,ML00006950,,,CCCCC[C@@H]1/C=C\C2[C@H](O)C[C@H](O)[C@@H]2CCCCCCC(=O)O1,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00006950_numbered.png,2026-03-19 06:55:12.599919
1909,ML00006681,,,C/C=C/CNC(=N)NCCCCCCCCN1CCCCOC(=O)CCNC(=N)NC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1910,ML00008036,,,C/C1=C/C(=O)OC[C@@]2(C)O[C@@H]2CC/C(C)=C\CC1,standard_macrolactone,13.0,,,success,,3.0,"[4, 8, 12]",ring_size_13/standard/numbered/ML00008036_numbered.png,2026-03-19 06:55:12.633752
1911,ML00003598,,,C/C=C1\CC(c2cccc(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCC3C=CC4CC(=O)CC3C42)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00003598_numbered.png,2026-03-19 06:55:12.666699
1912,ML00005016,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1913,ML00005225,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C[C@H]2CNC(=N)N2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1914,ML00008225,,,C[C@H]1CCC/C=C\[C@@H]2CCC[C@H]2[C@H](O)/C=C\C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008225_numbered.png,2026-03-19 06:55:12.713737
1915,ML00007109,,,CC(=O)C[C@H](O)CC(=O)[C@@H]1OC(=O)CCCCC/C=C/Cc2ccccc21,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00007109_numbered.png,2026-03-19 06:55:12.736454
1916,ML00006637,,,CO[C@H]1C(=O)OC[C@H](O)c2cc(Cl)c3c(c2)[C@@]24O[C@]5(O)C(=C(C)C(=O)[C@]16O[C@@H]56)O[C@@]2([C@H](O)C[C@H]4O)[C@@H]3O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1917,ML00008105,,,C/C1=C/COc2ccc(cc2)/C=C/C(=O)OC1,non_standard_macrocycle,13.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
1918,ML00005209,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1919,ML00009459,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](NC)[C@H]2O)[C@@]2(C)C[C@H](C)[C@H](O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1920,ML00010277,,,COC(=O)CCCC(=O)O[C@H]1C[C@H]2/C=C/CCC[C@H](C)OC(=O)/C=C/[C@@H](OC(=O)CCCC(=O)OC)[C@@H]2C1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00010277_numbered.png,2026-03-19 06:55:12.793742
1921,ML00004503,,,CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](COP(=O)(O)O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)C(C)C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1922,ML00010092,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1923,ML00003677,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1924,ML00003601,,,C/C=C1\CC(c2cccc(CO)c2)C#CC2CC(=O)Oc3c2cc(c(O)c3CC)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00003601_numbered.png,2026-03-19 06:55:12.850018
1925,ML00008038,,,CC(=O)O[C@@H]1[C@@H]2C(=O)N1C(=O)CCCCCCC(=O)O[C@@H]2C,non_standard_macrocycle,13.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
1926,ML00009116,,,CC[C@H]1OC(=O)[C@H](C)[C@@]2(O)O[C@@](C)(C[C@@H](C)/C(=N\OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1927,ML00008923,,,O=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)N[C@@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1928,ML00005426,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1929,ML00010174,,,C[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1930,ML00007204,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1931,ML00001833,CHEMBL2373671,,C[C@@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@@H]2[C@H](O)/C=C\C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00001833_numbered.png,2026-03-19 06:55:12.918179
1932,ML00005387,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1933,ML00010284,,,CC(C)/C=C/C=C/C=C/[C@H]1OC(=O)C[C@@H]2O[C@H](CC(=O)[C@@]3(O)O[C@H](C[C@H]3C)C1(C)C)C[C@H](O)[C@H]2C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1934,ML00008806,,,COCC[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008806_numbered.png,2026-03-19 06:55:12.963949
1935,ML00010289,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](C[C@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1936,ML00008917,,,O=C1NC[C@@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1937,ML00007798,,,C=C[C@@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00007798_numbered.png,2026-03-19 06:55:13.002933
1938,ML00010676,,,CC(C)(C)[C@@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1939,ML00008782,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](SCCO)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00008782_numbered.png,2026-03-19 06:55:13.040114
1940,ML00006744,,,O=C(/C=C/c1cc(Cl)ccc1-n1cnnn1)N[C@H]1C/C=C/COC(=O)Nc2ccccc2-c2nc1[nH]c2Cl,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1941,ML00008239,,,C[C@H]1CCC/C=C\[C@@H]2CC(=O)C[C@H]2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008239_numbered.png,2026-03-19 06:55:13.072425
1942,ML00008573,,,C/C1=C/C(=O)O[C@@H]2CC[N+]3([O-])CC[C@H](COC(=O)[C@](C)(O)[C@H](C)C1)[C@H]23,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1943,ML00003276,,,C/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(O)(CCC)C2CCC(=O)CC2)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00003276_numbered.png,2026-03-19 06:55:13.110872
1944,ML00005484,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1945,ML00009932,,,CCCCCCCC[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1946,ML00007558,,,CC(C)(C)[C@@H]1COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1947,ML00005573,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCc2cn(-c3cccnc3)nn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1948,ML00009144,,,C/C=C1\CC(c2cc(O)cc(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00009144_numbered.png,2026-03-19 06:55:13.171213
1949,ML00007050,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](OC3OC(CO)C(O)C(O)C3O)C[C@H]2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00007050_numbered.png,2026-03-19 06:55:13.196859
1950,ML00008085,,,C[C@@H]1C/C=C\C(=O)O[C@H](C)C[C@@H](CO)/C=C\C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1951,ML00010135,,,C[C@H]1COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1952,ML00007299,,,CC1=C[C@@H]2/C=C\C[C@H](C)C(=O)[C@@](C)(O)/C=C\OC(=O)O[C@]23C(=O)N[C@@H](Cc2ccc(O)cc2)[C@@H]3[C@@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1953,ML00006698,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([Se]Cc2ccccc2)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00006698_numbered.png,2026-03-19 06:55:13.245479
1954,ML00006861,,,COc1ccc(C[S+]([O-])[C@@H]2CC(=O)O[C@@H](C)CCC/C=C/[C@@H]3C[C@H](O)C[C@H]3[C@@H]2O)cc1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00006861_numbered.png,2026-03-19 06:55:13.276619
1955,ML00007586,,,O=C(O[C@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3cc(c(O)c(O)c3O)C(=O)O[C@@H]([C@@H]2O)[C@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1956,ML00007781,,,O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCC[C@H](CCO)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00007781_numbered.png,2026-03-19 06:55:13.313547
1957,ML00005429,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1958,ML00010504,,,O=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)OC[C@@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1959,ML00009545,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)[C@@H](O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1960,ML00008412,,,CC/C=C\C[C@H]1/C=C\[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O1,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00008412_numbered.png,2026-03-19 06:55:13.367815
1961,ML00007284,,,C[C@H]1C/C=C/[C@H]2[C@@H]3O[C@]3(C)[C@@H](C)[C@H]3[C@H](Cc4ccccc4)NC(=O)[C@@]23OC(=O)O/C=C/[C@@](C)(O)C1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1962,ML00008752,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](SCCN)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00008752_numbered.png,2026-03-19 06:55:13.408728
1963,ML00010926,,,CCCCC[C@@H](CC(=O)N1N=CCC[C@@H]1C(=O)N[C@H]1COC(=O)[C@H]2C[C@@H](O)CNN2C(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)NC1=O)C(=O)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1964,ML00010420,,,O=C(C[C@@H]1C/C=C/CC[C@H](Cc2ccc(F)cc2)C(=O)OCCNC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1965,ML00009780,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1966,ML00002482,,,C/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3c2cc(c(O)c3CC)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00002482_numbered.png,2026-03-19 06:55:13.471470
1967,ML00006540,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCc2cn(CC(=O)Nc3ccccn3)nn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1968,ML00004085,,,CC(C)CC/C=C1\CC(c2cccc(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00004085_numbered.png,2026-03-19 06:55:13.516187
1969,ML00008919,,,O=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)O[C@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1970,ML00001130,CHEMBL279862,,CCCCC1COC(=O)CC[C@H](NC(=O)C(Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC2CCCCC2)[C@@H](O)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1971,ML00009249,,,CCCCCCCC[C@@H](C)[C@@H]1OC(=O)[C@H](CO)NC(=O)[C@H](C(=O)c2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(=O)OC)NC(=O)[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1972,ML00004370,,,CC[C@H](C)[C@H](NC(=O)[C@@H](CCCCN)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1973,ML00009782,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1974,ML00009727,,,O=C1N[C@H](Cc2ccccc2)COC(=O)[C@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1975,ML00010498,,,O=C1OC[C@@H]2CCCN2C(=O)[C@H](CC(=O)N(CCO)Cc2ccccc2)C/C=C\CC[C@H]1Cc1ccc(F)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1976,ML00002654,,,CC(C)CCCCCCCCCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H]1COC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)[C@@H](C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1977,ML00006231,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCc2cn(-c3cccc4ccccc34)nn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1978,ML00008328,,,COc1cc(O)cc2c1C(=O)O[C@@H](C)CC[C@H]1CC[C@H](CC(=O)C2)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1979,ML00009513,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1980,ML00009941,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C[C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1981,ML00005294,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1982,ML00007836,,,C[Se][C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00007836_numbered.png,2026-03-19 06:55:13.658023
1983,ML00008024,,,O=C1CCC/C=C/CCOC(=O)c2c(O)cc(O)c(Cl)c2C1,standard_macrolactone,13.0,,,success,,1.0,[10],ring_size_13/standard/numbered/ML00008024_numbered.png,2026-03-19 06:55:13.683239
1984,ML00009728,,,O=C1N[C@@H](Cc2ccccc2)COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1985,ML00005385,,,CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(O[C@H]2O[C@@H](CO)[C@@H](O)[C@@H](O)[C@@H]2O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1986,ML00000084,CHEMBL2373582,,C[C@H]1CCC/C=C/[C@H]2C[C@H](OC(=O)CN(C)C)C[C@@H]2[C@@H](O)/C=C\C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00000084_numbered.png,2026-03-19 06:55:13.732519
1987,ML00010124,,,CC(C)CCC[C@@H]1CC(=O)N[C@H](c2c[nH]c3ccccc23)C(=O)N2CCC[C@H]2NC(=O)[C@@H](CCCNC(=N)N)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1988,ML00009325,,,COc1cc([C@H]2c3c(cc(OC)c(O)c3OC)C=C3C(=O)O[C@H]4[C@H](O)[C@@H](CO)O[C@@]4(CO)O[C@H]4O[C@H](COC(=O)[C@@H]32)[C@@H](O)[C@H](O)[C@H]4O)cc(OC)c1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1989,ML00002705,,,CO[C@H]1[C@H](C)O[C@H](O[C@@H]2[C@@H](OC(C)=O)CO[C@H](O[C@H]3C[C@H]4CC(=O)[C@]5(O)O[C@@H](C[C@@H]5C)C(C)(C)[C@H](/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)[C@H]2OC)[C@@H](OC)[C@@H]1OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1990,ML00008053,,,O=C1CCCCCCC/C=C\CCO1,standard_macrolactone,13.0,,,success,,0.0,[],ring_size_13/standard/numbered/ML00008053_numbered.png,2026-03-19 06:55:13.778511
1991,ML00008743,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])CCN)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00008743_numbered.png,2026-03-19 06:55:13.817579
1992,ML00001718,CHEMBL1592634,,O=C1CCC/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NCCO1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1993,ML00001058,CHEMBL1734306,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H](O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00001058_numbered.png,2026-03-19 06:55:13.858315
1994,ML00005217,,,CCC(C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC)[C@@H](C)CC)[C@H](C)CC)[C@@H](C)CC)[C@H](C)OC(=O)[C@H]([C@@H](C)CC)NC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1995,ML00003702,,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)C(C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([N+](C)(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1996,ML00000777,CHEMBL45141,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2CC(N(C)C(C)C)CC(C)O2)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1997,ML00009943,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C[C@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1998,ML00005457,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1999,ML00008547,,,C/C1=C/C(=O)O[C@@H]2CCN3CC[C@H](COC(=O)[C@@](C)(O)[C@@H](C)C1)[C@H]23,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2000,ML00007666,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](SCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00007666_numbered.png,2026-03-19 06:55:13.950836
2001,ML00006908,,,COC(=O)C[C@H]1C[C@@H]2COC(=O)[C@](C)(O)[C@H](C)C/C(C)=C\C(=O)O[C@@H]3CCN1[C@H]23,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2002,ML00008124,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)C(O)C(O)C(=O)O1,standard_macrolactone,13.0,,,success,,4.0,"[3, 11, 12, 13]",ring_size_13/standard/numbered/ML00008124_numbered.png,2026-03-19 06:55:13.994662
2003,ML00007824,,,O=C1OCCn2cc(F)cc(c2=O)[C@H]2CCCN2c2ccn3ncc1c3n2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2004,ML00008657,,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3C[C@@H](OC1=O)[C@@H](O)[C@@H]23,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2005,ML00003719,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CCF)[C@H]2O)[C@@]2(C)C[C@H](C)[C@H](O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2006,ML00001995,CHEMBL2204328,,CC(C)(C)C(=O)NCCOC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCC(=O)NCCOC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2007,ML00008410,,,CC(=O)O[C@@]1(C)C(=O)OC[C@H]2CC[N+]3([O-])CC[C@@H](OC(=O)/C=C(/C)C[C@H]1C)[C@@H]23,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2008,ML00003666,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CC#N)[C@H]2O)[C@@]2(C)C[C@H](C)[C@H](O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2009,ML00010679,,,CC(C)(C)[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2010,ML00008870,,,CCCC[C@H](C)[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]([C@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2011,ML00002004,CHEMBL1438792,,O=C1NC[C@@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2012,ML00000354,CHEMBL409855,BEAUVERIOLIDE III,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2013,ML00003944,,,C/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCC3C=CC4CC(=O)CC3C42)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00003944_numbered.png,2026-03-19 06:55:14.106174
2014,ML00001232,CHEMBL1269435,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2015,ML00008552,,,CC(=O)O[C@H]1C[C@H]2/C=C\CCC[C@H](C)OC(=O)/C=C/[C@@H](O)[C@@H]2C1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008552_numbered.png,2026-03-19 06:55:14.142773
2016,ML00007697,,,CCCCC[C@@H]1/C=C\C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O1,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00007697_numbered.png,2026-03-19 06:55:14.166772
2017,ML00005045,,,CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(=O)NCCN(C)C)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2018,ML00005382,,,CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(-c2ccc(C)cc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2019,ML00001822,CHEMBL184615,,O=C1CCCCCC/C=C2\CC(CO)(CO1)OC2=O,standard_macrolactone,13.0,,,success,,1.0,[4],ring_size_13/standard/numbered/ML00001822_numbered.png,2026-03-19 06:55:14.215647
2020,ML00007199,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2021,ML00006955,,,COC(=O)CCS[C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00006955_numbered.png,2026-03-19 06:55:14.256482
2022,ML00006667,,,O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCC[C@H](CCc2ccccc2)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00006667_numbered.png,2026-03-19 06:55:14.284105
2023,ML00008329,,,COc1cc(O)cc2c1C(=O)O[C@@H](C)CC[C@H]1CC[C@@H](CC(=O)C2)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2024,ML00008304,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](SCCCO)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00008304_numbered.png,2026-03-19 06:55:14.323330
2025,ML00010996,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2026,ML00006763,,,O=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2027,ML00005224,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C[C@H]2CNC(=N)N2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2028,ML00004091,,,CCNCC/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00004091_numbered.png,2026-03-19 06:55:14.384461
2029,ML00009515,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)C2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2030,ML00008037,,,C/C1=C/CC/C(C)=C\C(=O)OC/C(C)=C\CC1,standard_macrolactone,13.0,,,success,,3.0,"[4, 8, 12]",ring_size_13/standard/numbered/ML00008037_numbered.png,2026-03-19 06:55:14.423587
2031,ML00008427,,,C=C1CCC(/C=C/C)C(=O)OC2CCN3CC=C(COC(=O)C1(C)O)C23,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2032,ML00002852,,,C/C=C1\CC(c2cc(CO)cc(NCC(O)C3CCCCC3)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00002852_numbered.png,2026-03-19 06:55:14.466645
2033,ML00009721,,,C/C=C1\CC(c2cccc(CO)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(O)(CCC)C2CCC(=O)CC2)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00009721_numbered.png,2026-03-19 06:55:14.500632
2034,ML00007810,,,C[C@H]1C[C@@H]2O[C@H]2Cc2ccc(o2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2035,ML00000021,CHEMBL1559663,,C[C@H]1CCC/C=C/C2C[C@H](O)C[C@@]2(O)C/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 10]",ring_size_13/standard/numbered/ML00000021_numbered.png,2026-03-19 06:55:14.534819
2036,ML00010428,,,COc1ccc(C[C@H]2NC(=O)[C@]34OC(=O)O/C=C\[C@](C)(O)C(=O)[C@H](C)C/C=C\[C@@H]3[C@H]3O[C@@]3(C)[C@H](C)[C@H]24)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2037,ML00009547,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)[C@@H](O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2038,ML00002258,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(C)=O)[C@@H](C)OC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2039,ML00005291,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2040,ML00001087,CHEMBL1076336,,O=C(C[C@H]1C/C=C/CCCC(=O)OCCNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2041,ML00008781,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])CCO)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00008781_numbered.png,2026-03-19 06:55:14.616006
2042,ML00008150,,,C[C@H]1CCCCC[C@@H]2C[C@H](O)C[C@H]2[C@H](O)CCC(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008150_numbered.png,2026-03-19 06:55:14.643830
2043,ML00008303,,,CC(O)CS[C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00008303_numbered.png,2026-03-19 06:55:14.677229
2044,ML00007348,,,C[C@H]1C/C=C\[C@H]2[C@@H](O)[C@@H](C)[C@@H](C)[C@H]3[C@H](Cc4ccccc4)NC(=O)[C@@]23OC(=O)O/C=C\[C@@](C)(O)C1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2045,ML00002549,,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3cc(c(O)c(O)c3O)C(=O)[C@]34O[C@@H]2[C@H](O3)[C@H]1OC(=O)c1cc(O)c(O)c2c1[C@@H]1C(=CC(=O)C(O)(O)[C@]1(O)O2)C4=O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2046,ML00007201,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2047,ML00009718,,,O=C1N[C@@H](Cc2ccccc2)COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2048,ML00007207,,,CCCCCC[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H](CC(C)C)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2049,ML00006264,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCc2cn(CC(=O)OCc3ccccc3)nn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2050,ML00000176,CHEMBL516093,BEAUVERIOLIDE I,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H](CC(C)C)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2051,ML00007047,,,CCCCC[C@H]1/C=C\[C@H]2[C@H](OC(C)=O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O1,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00007047_numbered.png,2026-03-19 06:55:14.756763
2052,ML00010093,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2053,ML00007799,,,C=C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00007799_numbered.png,2026-03-19 06:55:14.799935
2054,ML00006770,,,CC(=O)Nc1ccc(CC[C@H]2CCC/C=C/[C@@H]3C[C@H](O)C[C@H]3[C@H](O)/C=C/C(=O)O2)cc1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00006770_numbered.png,2026-03-19 06:55:14.827483
2055,ML00004181,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C(C)C)[C@H]3O)[C@@]3(C)CC(C)=C(O3)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CCO)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2056,ML00010980,,,CC(C)CCC[C@H]1CC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2057,ML00008507,,,CC[C@@H]1/C=C\[C@@H](O)[C@@H](O)C/C=C/c2cc(OC)cc(O)c2C(=O)O[C@H]1C,standard_macrolactone,13.0,,,success,,4.0,"[3, 4, 7, 8]",ring_size_13/standard/numbered/ML00008507_numbered.png,2026-03-19 06:55:14.881418
2058,ML00010749,,,C=C1NC(=O)[C@H]([C@H](C)O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C)[C@@H]([C@@H](C)[C@@H](O)CCCCCCCCCCCCC)OC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2059,ML00008749,,,O=C(C[C@H]1C/C=C\CCCC(=O)OC[C@H]2CCCN2C1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2060,ML00006541,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCc2cn(CSc3ccccc3)nn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](OC(=O)C(C)C)[C@]1(C)OC(=O)C(C)C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2061,ML00009722,,,O=C(C[C@@H]1C/C=C/CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H](Cc2ccccc2)NC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2062,ML00009559,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@H](C)[C@H](O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2063,ML00005193,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2064,ML00008416,,,CC[C@@H]1C[C@@H]1[C@H]1OC(=O)CCC/C=C\C/C=C\[C@@H]2[C@H]3O[C@H]3C[C@H]21,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00008416_numbered.png,2026-03-19 06:55:14.955519
2065,ML00008783,,,CCCCC[C@@H]1CCCCC[C@@H]2CC(=O)[C@](O)(CCC(=O)O1)O2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2066,ML00001931,CHEMBL1933478,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2067,ML00008415,,,CC[C@H]1C[C@H]1[C@@H]1OC(=O)CCC/C=C\C/C=C\[C@H]2[C@H]1C[C@@H]1O[C@@H]12,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00008415_numbered.png,2026-03-19 06:55:14.994059
2068,ML00009546,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)[C@H](O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2069,ML00006668,,,O=C1CCC/C=C\C[C@@H]2C(/C=C\[C@@H](CCc3ccccc3)O1)[C@H](O)C[C@@H]2O,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00006668_numbered.png,2026-03-19 06:55:15.028049
2070,ML00000703,CHEMBL351216,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2071,ML00007037,,,CC/C=C\C[C@H]1/C=C\[C@H]2[C@H](OC(C)=O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O1,standard_macrolactone,13.0,,,success,,1.0,[3],ring_size_13/standard/numbered/ML00007037_numbered.png,2026-03-19 06:55:15.061649
2072,ML00008327,,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)/C=C\C(C)(C)COC2=O,standard_macrolactone,13.0,,,success,,4.0,"[4, 4, 7, 8]",ring_size_13/standard/numbered/ML00008327_numbered.png,2026-03-19 06:55:15.104372
2073,ML00004090,,,C/C=C1\CC(c2cc(CO)cc(NCC(C)(O)CCOC)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00004090_numbered.png,2026-03-19 06:55:15.141151
2074,ML00006775,,,O=C(C[C@@H]1C/C=C\CCCC(=O)OC[C@@H]2CCCN2C1=O)N[C@@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2075,ML00005197,,,CC[C@H](C)[C@H](NC(=O)C(Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2076,ML00007796,,,CC(=O)[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00007796_numbered.png,2026-03-19 06:55:15.188032
2077,ML00008088,,,C[C@H]1C/C(CO)=C\CC(=O)O[C@H](C)C/C=C\C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2078,ML00008549,,,C/C1=C/C(=O)O[C@@H]2CCN3CC[C@H](COC(=O)[C@](C)(O)[C@H](C)C1)[C@H]23,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2079,ML00007205,,,CCCC[C@H](C)C[C@H]1NC(=O)[C@@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)C[C@@H](C(C)C)OC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2080,ML00007016,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H](Sc2ccccc2N)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00007016_numbered.png,2026-03-19 06:55:15.238201
2081,ML00010733,,,CCCCCCCCCCCCC[C@H](O)[C@H](C)[C@H]1OC(=O)[C@@H](CO)NC(=O)[C@@H]([C@H](C)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2082,ML00003678,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2083,ML00010750,,,C=C1NC(=O)[C@H]([C@H](C)OS(=O)(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C)[C@@H]([C@@H](C)[C@@H](O)CCCCCCCCCCCCC)OC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2084,ML00002706,,,CO[C@@H]1[C@H](O[C@@H]2C[C@@H]3CC(=O)[C@]4(O)O[C@H](C[C@H]4C)C(C)(C)[C@@H](/C=C/C=C/C=C/C(C)C)OC(=O)C[C@H](O3)[C@@H]2C)OC[C@@H](O)[C@H]1O[C@@H]1O[C@H](C)[C@@H](OC)[C@H](OC)[C@H]1OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2085,ML00007470,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](OC(=O)CCCC(=O)O)C[C@H]2[C@H](OC(=O)CCCC(=O)O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00007470_numbered.png,2026-03-19 06:55:15.292434
2086,ML00002484,,,C/C=C1\CC(c2cc(NCC(C)O)cc(C(O)CNC)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00002484_numbered.png,2026-03-19 06:55:15.325477
2087,ML00008319,,,C/C1=C/C(=O)O[C@@H]2CC[N+]3(CCl)CC[C@H](COC(=O)[C@](C)(O)[C@H](C)C1)[C@H]23,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2088,ML00007161,,,C#CCCC[C@H]1C[C@@H](C)CC[C@@H](C)C[C@H](C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2089,ML00005370,,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2090,ML00008394,,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([S+]([O-])CC(O)CO)CC(=O)O1,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 12]",ring_size_13/standard/numbered/ML00008394_numbered.png,2026-03-19 06:55:15.378926
2091,ML00003595,,,C/C=C1\CC(c2cccc(C(O)CNC)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,success,,3.0,"[3, 11, 13]",ring_size_13/standard/numbered/ML00003595_numbered.png,2026-03-19 06:55:15.410881
2092,ML00010282,,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CC(C)C)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2093,ML00000675,CHEMBL353526,,CCC1OC(=O)C(C)C(OC2C[C@@](C)(OC)[C@@H](O)C(C)O2)C[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2094,ML00002090,CHEMBL339114,,CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)N[C@H]1CCC(=O)OCCOC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2095,ML00002933,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)C23C(C)C2NC(COCCOC)OC3C1(C)O,standard_macrolactone,13.0,,,success,,10.0,"[3, 4, 4, 7, 9, 9, 10, 11, 12, 13]",ring_size_13/standard/numbered/ML00002933_numbered.png,2026-03-19 06:55:15.489690
2096,ML00006764,,,O=C(C[C@@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@@H]2CCCN2C1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2097,ML00008221,,,C[C@H]1CCC/C=C\[C@@H]2CC(=O)C[C@H]2C(=O)CCC(=O)O1,standard_macrolactone,13.0,,,success,,2.0,"[3, 11]",ring_size_13/standard/numbered/ML00008221_numbered.png,2026-03-19 06:55:15.524985
2098,ML00002747,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)Cc3ccccc3)[C@H]2O)[C@@]2(C)C[C@H](C)[C@H](O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2099,ML00004335,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004335_numbered.png,2026-03-19 06:55:15.593171
2100,ML00004141,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC#Cc2cc(-c3ncccn3)no2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00004141_numbered.png,2026-03-19 06:55:15.657410
2101,ML00002171,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\Oc3ccc(-n4cccn4)nc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002171_numbered.png,2026-03-19 06:55:15.722930
2102,ML00000196,CHEMBL3092224,,CC(=O)OCC1=C(C)C[C@H]([C@@H](C)[C@H]2CC[C@H]3[C@@H]4C[C@H]5O[C@]56[C@@H]5C=CC(=O)[C@]6(COC(=O)CC/C=C/CCC(=O)O5)[C@H]4CC[C@@]32C)OC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2103,ML00003614,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)[C@@H](N)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003614_numbered.png,2026-03-19 06:55:15.811311
2104,ML00006326,,,CCC(=O)O[C@H]1[C@@H](OC(C)=O)[C@]2(COC(C)=O)[C@@H](OC(=O)c3ccccc3)[C@@H](O)[C@@H]3OC(=O)[C@@H](C)[C@@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@]2([C@H](OC(=O)c2ccccc2)[C@@H]14)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2105,ML00005496,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCSc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005496_numbered.png,2026-03-19 06:55:15.896848
2106,ML00001213,CHEMBL1256555,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001213_numbered.png,2026-03-19 06:55:15.969909
2107,ML00004741,,,CCCCCNC(=O)CCCCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004741_numbered.png,2026-03-19 06:55:16.045323
2108,ML00002759,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C/C=C/Cn3cnc(-c4cccnc4)c3)C(=O)N[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002759_numbered.png,2026-03-19 06:55:16.112277
2109,ML00005750,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005750_numbered.png,2026-03-19 06:55:16.189061
2110,ML00002372,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCn1cnc(-c2cccnc2)c1,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002372_numbered.png,2026-03-19 06:55:16.251438
2111,ML00002073,CHEMBL1078360,,COc1ccc(CO[C@@H]2/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c3cc(OC)cc(O)c3C(=O)O[C@H]2C)cc1,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00002073_numbered.png,2026-03-19 06:55:16.294083
2112,ML00003050,,,C=CCCC(=O)O[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003050_numbered.png,2026-03-19 06:55:16.370151
2113,ML00001751,CHEMBL1097413,,C[C@@H]1OC(=O)c2c(O)cc(NCc3ccccc3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001751_numbered.png,2026-03-19 06:55:16.415106
2114,ML00002884,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002884_numbered.png,2026-03-19 06:55:16.484406
2115,ML00003258,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2ccccn2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003258_numbered.png,2026-03-19 06:55:16.554493
2116,ML00009368,,,CC[C@@H]1OC(=O)C[C@@H](O[C@H]2C[C@@](C)(O)[C@H](O)[C@@H](C)O2)[C@H](C)[C@H](O[C@@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13]",ring_size_14/standard/numbered/ML00009368_numbered.png,2026-03-19 06:55:16.620686
2117,ML00001243,CHEMBL1256546,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001243_numbered.png,2026-03-19 06:55:16.688948
2118,ML00007923,,,C[C@H]1CCCC(=O)CCC/C=C\c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007923_numbered.png,2026-03-19 06:55:16.715093
2119,ML00002687,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cncc3ccccc23)[C@H](C)[C@@H]2OC(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002687_numbered.png,2026-03-19 06:55:16.778786
2120,ML00005827,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCc3ccnc4ccccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005827_numbered.png,2026-03-19 06:55:16.844433
2121,ML00008345,,,COc1cc(O)c2c(c1)/C=C/CCCC(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008345_numbered.png,2026-03-19 06:55:16.872709
2122,ML00002376,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCCc3ccccc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002376_numbered.png,2026-03-19 06:55:16.941473
2123,ML00003196,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@](C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2124,ML00002206,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3cccnc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2125,ML00001077,CHEMBL1097699,,C[C@@H]1OC(=O)c2c(O)cc(NCCO)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001077_numbered.png,2026-03-19 06:55:17.003621
2126,ML00010967,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3O[C@@](O)(C2)[C@H](C)C(=O)O[C@@H](/C=C/C=C/Br)C[C@@H](C)/C=C\C[C@H](O)[C@@H]3C)[C@H](OC)[C@@H]1OC,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2127,ML00000233,CHEMBL1214761,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000233_numbered.png,2026-03-19 06:55:17.071577
2128,ML00003989,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccco1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2129,ML00006237,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCC(=O)NC3CCCCC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006237_numbered.png,2026-03-19 06:55:17.148582
2130,ML00006525,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006525_numbered.png,2026-03-19 06:55:17.212653
2131,ML00007136,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00007136_numbered.png,2026-03-19 06:55:17.271968
2132,ML00005953,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC/C=C/c2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005953_numbered.png,2026-03-19 06:55:17.332830
2133,ML00010656,,,C/C(=C/C=C\C[C@H](O)C[C@@H]1CCC[C@H]2O[C@@](O)(CC[C@@H]3CC[C@H](O3)C(=O)O1)[C@H](O)[C@@H](O)[C@@H]2C)C/C=C\C=C/CCO,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2134,ML00001472,CHEMBL418067,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C3CCCCC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001472_numbered.png,2026-03-19 06:55:17.402104
2135,ML00003019,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2136,ML00002164,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(-c4csnn4)nc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002164_numbered.png,2026-03-19 06:55:17.480817
2137,ML00001700,CHEMBL1097784,,C[C@@H]1OC(=O)c2c(O)cc(OCCn3ccnn3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001700_numbered.png,2026-03-19 06:55:17.521824
2138,ML00003953,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2139,ML00006239,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OCCNCCCCNCc2ccc(Oc3ccccc3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006239_numbered.png,2026-03-19 06:55:17.605888
2140,ML00005530,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005530_numbered.png,2026-03-19 06:55:17.679766
2141,ML00004500,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNCc2cccc([N+](=O)[O-])c2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004500_numbered.png,2026-03-19 06:55:17.757108
2142,ML00010508,,,COc1ccc(C2CC(=O)Oc3cc4c(c(OC)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1OC(C)C,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010508_numbered.png,2026-03-19 06:55:17.785119
2143,ML00002427,,,CC[C@H]1OC(=O)[C@H](C)C(=O)C[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)C[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 7, 8, 10, 10, 11, 13, 14]",ring_size_14/standard/numbered/ML00002427_numbered.png,2026-03-19 06:55:17.840755
2144,ML00006071,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCCC2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006071_numbered.png,2026-03-19 06:55:17.907934
2145,ML00003489,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccc([N+](=O)[O-])c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003489_numbered.png,2026-03-19 06:55:17.977537
2146,ML00007039,,,C=C1/C=C(\C)[C@H](CC)OC(=O)[C@@H](C)C(=O)[C@](C)(CO)C/C(OC)=C/[C@@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00007039_numbered.png,2026-03-19 06:55:18.028334
2147,ML00000948,CHEMBL12589,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCNC2=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000948_numbered.png,2026-03-19 06:55:18.091505
2148,ML00000007,CHEMBL532,ERYTHROMYCIN,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000007_numbered.png,2026-03-19 06:55:18.162372
2149,ML00000269,CHEMBL313882,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)NC2CCCCC2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000269_numbered.png,2026-03-19 06:55:18.190869
2150,ML00000674,CHEMBL3392931,,CC[C@@H]1OC(=O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@](C)(O)C[C@H](C)C(=O)[C@@H](C)[C@H](O)[C@@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000674_numbered.png,2026-03-19 06:55:18.260022
2151,ML00002893,,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)N/C=C/c2ccc(-c3ccccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002893_numbered.png,2026-03-19 06:55:18.322347
2152,ML00004491,,,CCCCCCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)CCCCCCC)[C@@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004491_numbered.png,2026-03-19 06:55:18.391549
2153,ML00004170,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)C(N)C(C)C(OC(=O)O)C1(C)OC(=O)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004170_numbered.png,2026-03-19 06:55:18.463018
2154,ML00007129,,,COc1cc(O)c2c(c1)/C=C/C[C@@H]1OC(C)(C)O[C@@H]1C(=O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007129_numbered.png,2026-03-19 06:55:18.492151
2155,ML00008337,,,COc1cc(O)c2c(c1)CCCC(O)C(O)C(=O)C=CCC(C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008337_numbered.png,2026-03-19 06:55:18.525233
2156,ML00001076,CHEMBL1669776,,CC(=O)Oc1cc2c(c(OC(C)=O)c1)C(=O)OCCCCCCCCCC2,standard_macrolactone,14.0,,,success,,0.0,[],ring_size_14/standard/numbered/ML00001076_numbered.png,2026-03-19 06:55:18.545003
2157,ML00003167,,,C=C[C@]12OC(=O)N(CCCCn3cc(Cl)c4ncccc43)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003167_numbered.png,2026-03-19 06:55:18.605840
2158,ML00009453,,,CCCCNC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009453_numbered.png,2026-03-19 06:55:18.676392
2159,ML00007149,,,COC1C=CCCC=CC(=O)OC(C(C)C(=O)CCCC2CC(=O)NC(=O)C2)C(C)=CC(C)C1O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 6, 7, 8]",ring_size_14/standard/numbered/ML00007149_numbered.png,2026-03-19 06:55:18.714056
2160,ML00009301,,,CC(=O)OCC12C(OC(C)=O)C(=O)C3C(O)C14OC3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)OC(C(OC(C)=O)C2OC(C)=O)C4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2161,ML00003145,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nc(-c4ccccc4)cs3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003145_numbered.png,2026-03-19 06:55:18.783869
2162,ML00008243,,,C[C@H]1COC(=O)CC=C[C@@H](C)[C@@H]2C=C[C@H](O)[C@@H](COC1=O)O2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2163,ML00005931,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)C(C)C)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/C=C/c2cccnc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005931_numbered.png,2026-03-19 06:55:18.861520
2164,ML00001532,CHEMBL3650149,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CN2CCOCC2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(=O)CN(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)C2N(CCCOc3cc(C(=O)Nc4c(Cl)cncc4Cl)ccc3OC)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001532_numbered.png,2026-03-19 06:55:18.928479
2165,ML00000034,CHEMBL1651523,,COc1cc(O)c2c(c1)CCCCCC(=O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00000034_numbered.png,2026-03-19 06:55:18.956095
2166,ML00009553,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009553_numbered.png,2026-03-19 06:55:19.025362
2167,ML00006611,,,CC[C@H](C)[C@@]1(O)CC(=O)O[C@H](C)[C@@](O)(C(C)C)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2168,ML00007718,,,COc1cc(O)c2c(c1Br)C(=O)OCC(=O)NCC(=S)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2169,ML00010790,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)/C(C)=C/[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00010790_numbered.png,2026-03-19 06:55:19.097442
2170,ML00007749,,,COc1cc(O)c2c(c1Br)C(=O)OCCNCC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2171,ML00009771,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(=O)[C@@H](C)[C@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@]1([C@H](OC(C)=O)[C@@H]4C(=O)[C@@H]2OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2172,ML00008527,,,COc1cc(O)c(Cl)c2c1C(=O)OC(C)CCC(=O)CCC(OC)CC(=O)C2,standard_macrolactone,14.0,,,success,,4.0,"[3, 6, 9, 11]",ring_size_14/standard/numbered/ML00008527_numbered.png,2026-03-19 06:55:19.145632
2173,ML00007060,,,CC(C)[C@@]1(O)C(=O)OCC2=CCN3CC[C@@H](OC(=O)[C@@](O)(C(C)C)[C@@H](O)C(=O)O[C@@H]1C)[C@@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2174,ML00010907,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(N)=O)C[C@@H](C)/C(=N\O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00010907_numbered.png,2026-03-19 06:55:19.215601
2175,ML00000629,CHEMBL2375656,,COc1cc(O)c2c(c1)CC(=O)CCCC(=O)CCC[C@@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 11]",ring_size_14/standard/numbered/ML00000629_numbered.png,2026-03-19 06:55:19.245486
2176,ML00007751,,,C[C@H]1C[C@H]2O[C@@H]2CC/C=C\C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007751_numbered.png,2026-03-19 06:55:19.272046
2177,ML00001211,CHEMBL1256537,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001211_numbered.png,2026-03-19 06:55:19.340294
2178,ML00009419,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009419_numbered.png,2026-03-19 06:55:19.401700
2179,ML00000229,CHEMBL1214762,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000229_numbered.png,2026-03-19 06:55:19.475799
2180,ML00006585,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(O)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006585_numbered.png,2026-03-19 06:55:19.545422
2181,ML00000113,CHEMBL1668417,,COc1cc(O)c2c(c1)/C=C\CCCC(=O)C[C@H](Br)C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 5, 7]",ring_size_14/standard/numbered/ML00000113_numbered.png,2026-03-19 06:55:19.575614
2182,ML00005203,,,CCCCCCCCCCCCC(=O)O[C@H]1[C@H](C)OC(O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc3ccccc3)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005203_numbered.png,2026-03-19 06:55:19.645399
2183,ML00010251,,,COc1ccc(OC)c(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)c1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010251_numbered.png,2026-03-19 06:55:19.673010
2184,ML00003453,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003453_numbered.png,2026-03-19 06:55:19.740738
2185,ML00002887,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc3cccnc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2CC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002887_numbered.png,2026-03-19 06:55:19.800881
2186,ML00009195,,,CO[C@@]12CC[C@@H]3CC[C@H](O3)C(=O)O[C@H](C[C@@H](O)C/C=C\C=C(\C)C/C=C\C=C/CCO)CCC[C@@H](O1)[C@@H](C)[C@H](O)[C@H]2O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2187,ML00004749,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3cccnc3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4ccc5cccnc54)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004749_numbered.png,2026-03-19 06:55:19.869332
2188,ML00006166,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc4ncccc43)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006166_numbered.png,2026-03-19 06:55:19.930611
2189,ML00006420,,,CCCNC(=O)CCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006420_numbered.png,2026-03-19 06:55:19.999281
2190,ML00006608,,,CC[C@H](C)[C@]1(O)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](O)(C(C)C)[C@@H](C)OC(=O)[C@@H]1O)[C@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2191,ML00003134,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2ccc(-c3ccccn3)s2)C[C@@H](C)/C(=N\OC)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003134_numbered.png,2026-03-19 06:55:20.066451
2192,ML00004320,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](O)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cc(-c4ccccn4)nn3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004320_numbered.png,2026-03-19 06:55:20.126689
2193,ML00006019,,,C/C=C/C(=O)OC1C(OC(=O)c2ccc(=O)n(C)c2)C2OC(=O)C(C)C(C)c3ncccc3C(=O)OCC3(C)OC4(C(OC(C)=O)C3C(OC(C)=O)C(OC(C)=O)C14COC(C)=O)C2(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2194,ML00008107,,,O=C1CCCCCCCCCCCCO1,standard_macrolactone,14.0,,,success,,0.0,[],ring_size_14/standard/numbered/ML00008107_numbered.png,2026-03-19 06:55:20.153913
2195,ML00001089,CHEMBL1078777,,CC[C@H]1C/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(OC)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001089_numbered.png,2026-03-19 06:55:20.186608
2196,ML00009810,,,C=C1NC(=O)[C@@H](C)[C@@H](CC[C@@H](C)C(=O)/C=C/C(C)=C/C[C@@H](C)CCCCCCC)OC(=O)[C@H](C[C@@H](OS(=O)(=O)O)C(N)=O)NC(=O)[C@@H](C)CNC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2197,ML00004318,,,C=CCO[C@@H]1C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)COc2ccccc2)[C@H](C)[C@H]1OC1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004318_numbered.png,2026-03-19 06:55:20.254511
2198,ML00009730,,,COc1c2c(cc3c1C(c1cc4cc(C)ccc4n(CC(C)C)c1=O)CC(=O)O3)C=CCCCC(=O)CCCC(C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00009730_numbered.png,2026-03-19 06:55:20.284323
2199,ML00002245,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cccc3cccnc23)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002245_numbered.png,2026-03-19 06:55:20.352374
2200,ML00006999,,,C[C@@H]1OC(=O)c2c(O)cc(NOCC(=O)O)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00006999_numbered.png,2026-03-19 06:55:20.393426
2201,ML00004222,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004222_numbered.png,2026-03-19 06:55:20.460869
2202,ML00004042,,,O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]3[C@H](O)O[C@@H]2COC(=O)c2cc(O)c(O)c3oc(=O)c4cc(O)c(O)c(c4c23)Oc2c1cc(O)c(O)c2O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2203,ML00001217,CHEMBL2159138,,CC/N=C1\O[C@H]2[C@H](O[C@@H]3[C@@H](C)[C@H](O[C@H]4C[C@@](C)(OC)[C@@H](O)[C@H](C)O4)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]3(C)OC)O[C@H](C)C[C@@H]2N1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001217_numbered.png,2026-03-19 06:55:20.548221
2204,ML00001709,CHEMBL1099011,,CCCOc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001709_numbered.png,2026-03-19 06:55:20.589172
2205,ML00006993,,,COc1cc(O)c2c(c1Br)C(=O)OCCN(C(=O)[C@H](C)N)CC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2206,ML00004815,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(-c5ccccc5)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004815_numbered.png,2026-03-19 06:55:20.676117
2207,ML00006401,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NCC#Cc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006401_numbered.png,2026-03-19 06:55:20.746018
2208,ML00002892,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2cnc3ccccc3c2)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002892_numbered.png,2026-03-19 06:55:20.805240
2209,ML00010223,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010223_numbered.png,2026-03-19 06:55:20.861122
2210,ML00010183,,,COc1ccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)c(OC)c1OC,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010183_numbered.png,2026-03-19 06:55:20.888973
2211,ML00001226,CHEMBL1256547,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001226_numbered.png,2026-03-19 06:55:20.956025
2212,ML00004121,,,C=CCO[C@@H]1C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccc(Cl)cc2)[C@H](C)[C@H]1OC1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004121_numbered.png,2026-03-19 06:55:21.015406
2213,ML00008739,,,COc1cc(O)c(Cl)c2c1C(=O)O[C@@H](C)CCC(=O)CC/C=C\C(=O)C2,standard_macrolactone,14.0,,,success,,3.0,"[3, 6, 11]",ring_size_14/standard/numbered/ML00008739_numbered.png,2026-03-19 06:55:21.046646
2214,ML00004292,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(C(N)=O)s3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00004292_numbered.png,2026-03-19 06:55:21.111745
2215,ML00008391,,,COc1cc(O)c2c(c1)/C=C\C[C@H](O)[C@@H](O)C(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008391_numbered.png,2026-03-19 06:55:21.147421
2216,ML00000956,CHEMBL276217,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@H]2CC(C)C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000956_numbered.png,2026-03-19 06:55:21.289969
2217,ML00001604,CHEMBL584552,,CCNC(=O)CO[C@H]1[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001604_numbered.png,2026-03-19 06:55:21.367499
2218,ML00005492,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCc2cccs2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005492_numbered.png,2026-03-19 06:55:21.471013
2219,ML00009015,,,CO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@]3(CO3)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009015_numbered.png,2026-03-19 06:55:21.538932
2220,ML00002180,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3cccc(C(N)=O)c3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002180_numbered.png,2026-03-19 06:55:21.617729
2221,ML00000937,CHEMBL416337,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCN(C)C2=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000937_numbered.png,2026-03-19 06:55:21.694413
2222,ML00006422,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006422_numbered.png,2026-03-19 06:55:21.772054
2223,ML00003623,,,CCOCCCNC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003623_numbered.png,2026-03-19 06:55:21.846303
2224,ML00002317,,,CCCC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002317_numbered.png,2026-03-19 06:55:21.923285
2225,ML00003033,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2226,ML00009808,,,C=C1NC(=O)C(C)C(CCC(C)C(=O)C=CC(C)=CCC(C)CCCCCCC)OC(=O)[C@H](CC(OS(=O)(=O)O)C(N)=O)NC(=O)[C@@H](C)CNC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2227,ML00002868,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=N\OCc3cc(-c4cccc(C#N)n4)no3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002868_numbered.png,2026-03-19 06:55:22.010663
2228,ML00007873,,,C[C@H]1CCCC(=O)CCCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007873_numbered.png,2026-03-19 06:55:22.040496
2229,ML00009657,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2230,ML00005356,,,CCOC(=O)c1cn(CC)c2ccc(CCCN3CCN(CCC(=O)O[C@H]4[C@H](C)O[C@@H](O[C@H]5[C@H](C)[C@@H](O[C@@H]6O[C@H](C)C[C@H](N(C)C)[C@H]6O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]5C)C[C@@]4(C)OC)CC3)cc2c1=O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005356_numbered.png,2026-03-19 06:55:22.130483
2231,ML00005706,,,CC(=O)O[C@@H]1[C@H](OC(=O)C(C)C)[C@@H]2[C@@H](OC(C)=O)[C@@]34O[C@@]2(C)COC(=O)c2cccnc2C[C@@H](C)C(=O)O[C@@H]([C@H](OC(=O)c2ccc(=O)n(C)c2)[C@H](OC(C)=O)[C@@]13COC(=O)C(C)C)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2232,ML00009647,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009647_numbered.png,2026-03-19 06:55:22.218483
2233,ML00000197,CHEMBL1315430,,CCC1OC(=O)C(C)[C@@H](O[C@H]2C[C@@](C)(OC)C(O)C(C)O2)C(C)[C@@H](O[C@@H]2OC(C)CC(N(C)C)C2O)[C@@](C)(O)CC(C)C(=O)[C@@H](C)C(O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000197_numbered.png,2026-03-19 06:55:22.294667
2234,ML00004842,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccc(NC(=O)Cc3ccccn3)nc2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004842_numbered.png,2026-03-19 06:55:22.366008
2235,ML00004466,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(-c5ccc(C)cc5)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004466_numbered.png,2026-03-19 06:55:22.444562
2236,ML00001810,CHEMBL4068569,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C(F)=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 6, 7, 8, 9]",ring_size_14/standard/numbered/ML00001810_numbered.png,2026-03-19 06:55:22.484971
2237,ML00005902,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O/C=C\Cc2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2Cl)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005902_numbered.png,2026-03-19 06:55:22.553614
2238,ML00001966,CHEMBL59405,,O=C(NC(Cc1ccccc1)C(O)CN1C/C=C\CCCCCCCC(c2ccccc2)OC1=O)O[C@H]1CO[C@H]2OCC[C@@H]12,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2239,ML00002246,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=C/c2cccc3cccnc23)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002246_numbered.png,2026-03-19 06:55:22.633806
2240,ML00005849,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N/C(C)=O)[C@H](C)[C@@H](OC/C(=N/OCc3ccc(-c4cccc(N)n4)s3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00005849_numbered.png,2026-03-19 06:55:22.709142
2241,ML00003517,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCc2ccc(Br)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003517_numbered.png,2026-03-19 06:55:22.785790
2242,ML00002154,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=C/c2cccc3ncccc23)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002154_numbered.png,2026-03-19 06:55:22.855557
2243,ML00004841,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccnc(NC(=O)Cc3ccccn3)c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004841_numbered.png,2026-03-19 06:55:22.924263
2244,ML00001786,CHEMBL3967300,,C[C@@H]1OC(=O)c2c(O)cc(N3CCNC3=O)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001786_numbered.png,2026-03-19 06:55:22.964473
2245,ML00007469,,,CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)/C=C/c2ccc(O)c(O)c2)[C@@H](C)OC(=O)[C@@H](C)CNC(=O)[C@@H](C)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2246,ML00004794,,,CCCCCCCCCCCCCCCCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004794_numbered.png,2026-03-19 06:55:23.053282
2247,ML00010253,,,COc1ccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1OC,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010253_numbered.png,2026-03-19 06:55:23.081114
2248,ML00006079,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc4ncccc43)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006079_numbered.png,2026-03-19 06:55:23.145324
2249,ML00009275,,,C=CCO[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)O[C@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@H](O)[C@H]1N(C)C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009275_numbered.png,2026-03-19 06:55:23.216000
2250,ML00010622,,,C[C@@H]1/C=C\[C@@H](C)[C@H](/C=C/C#C/C=C/C(C)(C)[C@H](O)c2cccc(O)c2Br)OC(=O)/C=C\C[C@H](C)C[C@H](OC(N)=O)C1,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 9, 11]",ring_size_14/standard/numbered/ML00010622_numbered.png,2026-03-19 06:55:23.256008
2251,ML00010793,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1cccc2ccccc12)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010793_numbered.png,2026-03-19 06:55:23.284620
2252,ML00002651,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCN(C)Cc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002651_numbered.png,2026-03-19 06:55:23.348555
2253,ML00004429,,,CCCCCCC(=O)O[C@H]1[C@H](C)OC(O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc3ccccc3)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004429_numbered.png,2026-03-19 06:55:23.422779
2254,ML00009220,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00009220_numbered.png,2026-03-19 06:55:23.481845
2255,ML00009644,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009644_numbered.png,2026-03-19 06:55:23.555556
2256,ML00008057,,,C[C@@H]1C/C=C\C(=O)O[C@H](C)C[C@@H](O)C/C=C\C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2257,ML00009811,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nncs3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009811_numbered.png,2026-03-19 06:55:23.625081
2258,ML00006389,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCCNCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006389_numbered.png,2026-03-19 06:55:23.698460
2259,ML00005945,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCc3ccnc4c(OC)cccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005945_numbered.png,2026-03-19 06:55:23.761264
2260,ML00002214,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C[C@@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2261,ML00008699,,,CCCCC[C@H]1CCCCC[C@@H](O)C[C@H](O)[C@H](O)/C=C/C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 9, 11, 12]",ring_size_14/standard/numbered/ML00008699_numbered.png,2026-03-19 06:55:23.814946
2262,ML00007935,,,C[C@@H]1C[C@@H](O)/C=C\CCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 5, 11]",ring_size_14/standard/numbered/ML00007935_numbered.png,2026-03-19 06:55:23.852350
2263,ML00006355,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2C(NC(=O)CCCCc3cnc4c(OC)cccc4c3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006355_numbered.png,2026-03-19 06:55:23.927663
2264,ML00005491,,,CC[C@H]1OC(=O)[C@H](C)C(O[C@H]2C[C@](C)(OC)[C@@H](O)[C@@H](C)O2)[C@H](C)C(O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCOc2ccc(OC)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005491_numbered.png,2026-03-19 06:55:24.055368
2265,ML00006046,,,CC/C=N/C(=O)CCCCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006046_numbered.png,2026-03-19 06:55:24.196844
2266,ML00009659,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2267,ML00006856,,,COc1cc(OCC(=O)NC(C)C)cc2c1C(=O)OC(C)CCCC(=O)CCCCC2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00006856_numbered.png,2026-03-19 06:55:24.307750
2268,ML00002588,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](N(C)C(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002588_numbered.png,2026-03-19 06:55:24.398442
2269,ML00008447,,,COc1cc2c(c(OC)c1)C(=O)O[C@@H](C)CCC[C@@H](O)CCCCC2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008447_numbered.png,2026-03-19 06:55:24.430950
2270,ML00006327,,,CCC(=O)O[C@H]1[C@@H](OC(C)=O)[C@]2(COC(C)=O)[C@@H](OC(=O)c3ccccc3)[C@@H](O)[C@@H]3OC(=O)[C@@H](C)[C@@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@@]2([C@H](OC(=O)c2ccccc2)[C@@H]14)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2271,ML00004276,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccncc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004276_numbered.png,2026-03-19 06:55:24.527146
2272,ML00002358,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NC/C=C/c3ccc(NC(C)=O)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00002358_numbered.png,2026-03-19 06:55:24.588499
2273,ML00006334,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](OC(=O)c1cccnc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2274,ML00006792,,,COC(=O)c1ccc(COc2cc(O)c3c(c2)C=CCCCC(=O)CCCC(C)OC3=O)o1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00006792_numbered.png,2026-03-19 06:55:24.625931
2275,ML00009736,,,COC(=O)c1cc(C(=O)OC)cc(-c2ccc(C3CC(=O)Oc4cc5c(c(OC)c43)C(=O)OC(C)CCCC(=O)CCCC=C5)o2)c1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00009736_numbered.png,2026-03-19 06:55:24.653365
2276,ML00000585,CHEMBL83070,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)N2CCCCCC2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000585_numbered.png,2026-03-19 06:55:24.763705
2277,ML00003340,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCCNCCN2CCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003340_numbered.png,2026-03-19 06:55:24.849306
2278,ML00005391,,,CCOC(=O)c1cn(C2CC2)c2ccc(CCCN3CCN(CCC(=O)O[C@H]4[C@H](C)O[C@@H](O[C@H]5[C@H](C)[C@@H](O[C@@H]6O[C@H](C)C[C@H](N(C)C)[C@H]6O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]5C)C[C@@]4(C)OC)CC3)cc2c1=O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005391_numbered.png,2026-03-19 06:55:24.922289
2279,ML00002662,,,CO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](OC(C)=O)[C@@H](C)C(=O)[C@@]3(CO3)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3OC(C)=O)[C@H]2C)O[C@@H](C)[C@@H]1OC(C)=O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002662_numbered.png,2026-03-19 06:55:24.985683
2280,ML00007549,,,C=C(CCC[C@@H](O)C[C@H](C)O)C[C@@H]1CC(=C)C[C@H](O)C/C(C)=C\[C@@H](O)CCCC(=O)O1,standard_macrolactone,14.0,,,success,,5.0,"[3, 5, 7, 9, 11]",ring_size_14/standard/numbered/ML00007549_numbered.png,2026-03-19 06:55:25.027692
2281,ML00009016,,,CO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@]3(CO3)C[C@H](C)[C@H](O[C@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009016_numbered.png,2026-03-19 06:55:25.090182
2282,ML00004377,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OCCNCCCOCCOCCOCCCNc2ccc(Oc3ccccc3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004377_numbered.png,2026-03-19 06:55:25.160471
2283,ML00002830,,,C=C[C@@H]1[C@H]2[C@H](/C=C/C=C/C=C/CCC)[C@H]2[C@@H]2C(=O)OC[C@]3(C)[C@H]4[C@@H]5C=C(CO)C[C@]6(O)C(=O)C(C)=C[C@H]6[C@@]5(O)[C@H](C)C[C@]43OC(=O)C/C=C\C=C[C@H]12,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2284,ML00008449,,,CCC1OC(=O)C(C)C(=O)/C(C)=C/C(C)CC(C)C(=O)/C=C/C1C,standard_macrolactone,14.0,,,success,,8.0,"[3, 4, 7, 8, 10, 12, 13, 14]",ring_size_14/standard/numbered/ML00008449_numbered.png,2026-03-19 06:55:25.223018
2285,ML00000995,CHEMBL528543,,C/C1=C/[C@@H](C)[C@H](O)[C@@H](O)/C=C/CC/C=C/C(=O)O[C@@H]1[C@H](C)C(=O)/C=C/CC1CC(=O)NC(=O)C1,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 6, 7, 8]",ring_size_14/standard/numbered/ML00000995_numbered.png,2026-03-19 06:55:25.262153
2286,ML00001676,CHEMBL1095163,,CCCCOc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001676_numbered.png,2026-03-19 06:55:25.301408
2287,ML00001710,CHEMBL1094226,,C[C@@H]1OC(=O)c2c(O)cc(OCC(O)CO)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001710_numbered.png,2026-03-19 06:55:25.341007
2288,ML00004433,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCCC(=O)NCCc3ccc(O)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004433_numbered.png,2026-03-19 06:55:25.414263
2289,ML00001434,CHEMBL1256549,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCF)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001434_numbered.png,2026-03-19 06:55:25.485270
2290,ML00003092,,,CCCN1C(C)O[C@@H]2[C@@H](C)[C@@H]1[C@H](C)C[C@@](C)(O)[C@H](OC1OC(C)CC(N(C)C)C1O)[C@@H](C)[C@H](OC1CC(C)(OC)C(O)C(C)O1)[C@@H](C)C(=O)O[C@H](CC)[C@@]2(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003092_numbered.png,2026-03-19 06:55:25.547034
2291,ML00001886,CHEMBL4061009,,COc1cc(O)c2c(c1)CCC[C@H](O)[C@H](O)[C@@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001886_numbered.png,2026-03-19 06:55:25.578738
2292,ML00004249,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(C(N)=O)s3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004249_numbered.png,2026-03-19 06:55:25.636761
2293,ML00003026,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3ccccc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2294,ML00009531,,,COC1CC(O[C@@H]2C(C)C(=O)O[C@H](C)[C@H](C)C(OC(C)=O)C(C)C(=O)[C@]3(CO3)C[C@H](C)[C@H](OC3OC(C)CC(N(C)C)[C@H]3O)[C@H]2C)OC(C)[C@@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009531_numbered.png,2026-03-19 06:55:25.701397
2295,ML00004158,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)[C@@H](N(C)C)[C@H](C)[C@@H](O)[C@@]12CO2,standard_macrolactone,14.0,,,success,,11.0,"[3, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004158_numbered.png,2026-03-19 06:55:25.762207
2296,ML00001882,CHEMBL1099198,,COc1cc(O)c2c(c1)OCC[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2297,ML00002434,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C/C=C/Cn3cnc4cccnc43)C(=O)N[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002434_numbered.png,2026-03-19 06:55:25.830395
2298,ML00003465,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccncc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CC3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003465_numbered.png,2026-03-19 06:55:25.899906
2299,ML00001872,CHEMBL3948014,,CCNc1cc(O)c2c(c1)/C=C/C[C@@H]1OC(=O)O[C@@H]1C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 4, 7]",ring_size_14/standard/numbered/ML00001872_numbered.png,2026-03-19 06:55:25.930199
2300,ML00007956,,,C[C@@H]1C[C@@H](O)CCCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 5, 11]",ring_size_14/standard/numbered/ML00007956_numbered.png,2026-03-19 06:55:25.958842
2301,ML00003082,,,CCCCCN[C@@H]1[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003082_numbered.png,2026-03-19 06:55:26.022073
2302,ML00000300,CHEMBL1404947,,CO[C@@H]1C[C@H](O[C@H]2[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)C[C@@H](N(C)C)[C@@H]3OC(C)=O)[C@H](C)C[C@]3(CO3)C(=O)[C@H](C)[C@H](OC(C)=O)[C@H](C)[C@H](C)OC(=O)[C@@H]2C)O[C@H](C)[C@@H]1OC(C)=O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000300_numbered.png,2026-03-19 06:55:26.078785
2303,ML00002529,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ncccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002529_numbered.png,2026-03-19 06:55:26.139446
2304,ML00001565,CHEMBL1269447,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCc2csc(C)n2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001565_numbered.png,2026-03-19 06:55:26.211340
2305,ML00006453,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@H]4C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2306,ML00007969,,,CC1C/C=C/C(O)C(O)CC/C=C/c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00007969_numbered.png,2026-03-19 06:55:26.252002
2307,ML00000930,CHEMBL3734946,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccccc3-c3cn(CCCCCC(=O)NO)nn3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000930_numbered.png,2026-03-19 06:55:26.317481
2308,ML00006565,,,C=CCCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@](C)(O)[C@H](OC(=O)CCC=C)[C@@H](C)C(=O)[C@H](C)C[C@]2(C)O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006565_numbered.png,2026-03-19 06:55:26.403785
2309,ML00007777,,,CO[C@@H]1/C=C\CC/C(C)=C\C/C(C)=C\C(=O)O[C@@H](CO)C1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 10, 13]",ring_size_14/standard/numbered/ML00007777_numbered.png,2026-03-19 06:55:26.440963
2310,ML00001693,CHEMBL3986872,,C[C@@H]1OC(=O)c2c(O)cc(NCCn3ccnc3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001693_numbered.png,2026-03-19 06:55:26.476593
2311,ML00005622,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCCCCc3ccnc4ccccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005622_numbered.png,2026-03-19 06:55:26.536037
2312,ML00003053,,,CC[C@H](C)[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@H](OC)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(C)=O)[C@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003053_numbered.png,2026-03-19 06:55:26.599533
2313,ML00009807,,,C=C1NC(=O)C(C)C(CCC(C)C(=O)/C=C/C(C)=C/CCC(C)CCCCCC)OC(=O)C(CCC(N)=O)NC(=O)C(C)CNC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2314,ML00002361,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)/C=C/c2ccc(F)cc2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002361_numbered.png,2026-03-19 06:55:26.676305
2315,ML00010759,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010759_numbered.png,2026-03-19 06:55:26.736485
2316,ML00008717,,,COc1cc(O)c2c(c1Br)C(=O)OCC(=O)N(C)CC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2317,ML00003880,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(C)=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003880_numbered.png,2026-03-19 06:55:26.806363
2318,ML00006069,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](OC(=O)NCCc3ccccc3)[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OC(=O)NCCc2ccccc2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006069_numbered.png,2026-03-19 06:55:26.866026
2319,ML00002191,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\Oc3ccc(-c4nccs4)nc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002191_numbered.png,2026-03-19 06:55:26.929777
2320,ML00003662,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\O)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003662_numbered.png,2026-03-19 06:55:26.998827
2321,ML00001403,CHEMBL3577622,,C#CCO[C@@H]1[C@@H](C)[C@H](OC(=O)NCCCCCCCNC(=N)NC(=O)NC)[C@@H](C)C(=O)O[C@H](CC)C(C)(C)[C@@H]2OC(C)(C)O[C@H]([C@@H]2C)[C@H](C)C[C@@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001403_numbered.png,2026-03-19 06:55:27.069033
2322,ML00003713,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)C(C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003713_numbered.png,2026-03-19 06:55:27.145234
2323,ML00000830,CHEMBL125014,,CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)N[C@H]1COC(=O)CCCC(CNC(=O)OCC(Cl)(Cl)Cl)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2324,ML00001080,CHEMBL1079557,,O=C(C[C@@H]1C/C=C/CCCCC(=O)OCCNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2325,ML00004434,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCCC(=O)NCc3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004434_numbered.png,2026-03-19 06:55:27.229108
2326,ML00003474,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003474_numbered.png,2026-03-19 06:55:27.283968
2327,ML00010514,,,CO[C@@H]1C[C@H]2C=C[C@H]3C[C@H]4O[C@]2(/C(C)=C\[C@@H]2COC(=O)CCC5=C(/C=C\OC[C@H](O)[C@H]2OC1=O)C(=O)OC5=O)[C@@H]3[C@@H](O)[C@H]4C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2328,ML00002446,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCC[C@@H]2c2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002446_numbered.png,2026-03-19 06:55:27.351472
2329,ML00002134,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=N\OCc3cc(-c4ccc(Br)s4)no3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002134_numbered.png,2026-03-19 06:55:27.408574
2330,ML00010690,,,COC(=O)c1ccc(-c2ccc(C3CC(=O)Oc4cc5c(c(O)c43)C(=O)OC(C)CCCC(=O)CCCC=C5)o2)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010690_numbered.png,2026-03-19 06:55:27.434272
2331,ML00004591,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc4cccnc43)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004591_numbered.png,2026-03-19 06:55:27.494921
2332,ML00003762,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003762_numbered.png,2026-03-19 06:55:27.565567
2333,ML00008974,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2nccs2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00008974_numbered.png,2026-03-19 06:55:27.635504
2334,ML00008998,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CCCCO2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)C2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00008998_numbered.png,2026-03-19 06:55:27.699921
2335,ML00009583,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cccs2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009583_numbered.png,2026-03-19 06:55:27.764123
2336,ML00001692,CHEMBL572017,,C/C=C1/[C@H]2OC=C(C(=O)O)[C@H]1CC(=O)OC[C@H](c1ccc(O)c(O)c1)OC[C@H]1O[C@@H](O2)[C@H](O)[C@@H](O)[C@@H]1O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2337,ML00003724,,,CO[C@]1(C)C[C@H](O[C@@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](C3CC3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003724_numbered.png,2026-03-19 06:55:27.835392
2338,ML00005963,,,CC[C@@H]1OC(=O)[C@@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@](C)(O[C@@H]2C[C@H](N(C)C)[C@H](O)[C@@H](C)O2)C[C@@H](C)C(=O)[C@H](O)[C@@H](O)C1(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005963_numbered.png,2026-03-19 06:55:27.901623
2339,ML00007895,,,C[C@H]1C/C=C/[C@@H](O)[C@@H](O)CCC(O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 11]",ring_size_14/standard/numbered/ML00007895_numbered.png,2026-03-19 06:55:27.932672
2340,ML00002774,,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccnc4ccccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002774_numbered.png,2026-03-19 06:55:27.993064
2341,ML00005890,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005890_numbered.png,2026-03-19 06:55:28.060294
2342,ML00005254,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCCCCOCC#Cc3ccc4c(c3)c(=O)c(C(=O)O)cn4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005254_numbered.png,2026-03-19 06:55:28.127165
2343,ML00002411,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C/C=C/Cc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002411_numbered.png,2026-03-19 06:55:28.183126
2344,ML00006660,,,C[C@H]1C/C=C/CC/C=C/C(=O)Cc2cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00006660_numbered.png,2026-03-19 06:55:28.208726
2345,ML00005950,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NN(CC)CCc2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005950_numbered.png,2026-03-19 06:55:28.267637
2346,ML00004157,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCCO)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004157_numbered.png,2026-03-19 06:55:28.333243
2347,ML00007921,,,CC1CCCC(=O)CCCC=Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007921_numbered.png,2026-03-19 06:55:28.358836
2348,ML00009572,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@](C)(F)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,14.0,"[3, 4, 4, 5, 6, 7, 8, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009572_numbered.png,2026-03-19 06:55:28.427432
2349,ML00003031,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2350,ML00008395,,,COc1cc(O)c(Cl)c2c1C(=O)O[C@@H](C)CCC(=O)CCCCC(=O)C2,standard_macrolactone,14.0,,,success,,3.0,"[3, 6, 11]",ring_size_14/standard/numbered/ML00008395_numbered.png,2026-03-19 06:55:28.463496
2351,ML00005970,,,CCCCCCCN[C@@H]1[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005970_numbered.png,2026-03-19 06:55:28.526549
2352,ML00001447,CHEMBL216252,,CCC(C)N(CC1CC1)[C@H]1C[C@@H](C)OC(O[C@@H]2[C@@H](C)[C@H](OC3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCc4ccc(Cl)cc4)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001447_numbered.png,2026-03-19 06:55:28.586461
2353,ML00008941,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCCN(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00008941_numbered.png,2026-03-19 06:55:28.648692
2354,ML00006826,,,O=C1OCC/C=C/CC/C=C/C(=N/OCC(=O)N2CCCCC2)Cc2cc(OP(=O)(O)O)cc(O)c21,standard_macrolactone,14.0,,,success,,1.0,[11],ring_size_14/standard/numbered/ML00006826_numbered.png,2026-03-19 06:55:28.671627
2355,ML00000422,CHEMBL3735212,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3cccc(-c4cn(CCCCCC(=O)NO)nn4)c3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000422_numbered.png,2026-03-19 06:55:28.724072
2356,ML00002109,CHEMBL3970233,,CN1Cc2cc(ccc2S(=O)(=O)C2CC2)NC(=O)OCc2cccc(c2)[C@@H](Nc2ccc3c(N)nccc3c2)C1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2357,ML00004235,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCCNCCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004235_numbered.png,2026-03-19 06:55:28.787969
2358,ML00010182,,,COc1cc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc(OC)c1OC,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010182_numbered.png,2026-03-19 06:55:28.815420
2359,ML00008229,,,CC1C(=O)OCCCn2ccc(c2)COC(=O)C(C)(O)C1(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2360,ML00002368,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nc(-c4cccnc4)c[nH]3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002368_numbered.png,2026-03-19 06:55:28.880080
2361,ML00009550,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009550_numbered.png,2026-03-19 06:55:28.941767
2362,ML00004293,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4ccccc4)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004293_numbered.png,2026-03-19 06:55:28.998396
2363,ML00005755,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)c2ccc(C(C)(C)C)cc2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005755_numbered.png,2026-03-19 06:55:29.065042
2364,ML00005876,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccnc4ccc(OC)cc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005876_numbered.png,2026-03-19 06:55:29.126232
2365,ML00005844,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)/C(C)=C/[C@]1(C)OC(=O)NCCCOc1ccc2ccccc2c1,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00005844_numbered.png,2026-03-19 06:55:29.190718
2366,ML00006169,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2cncc3ccccc23)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006169_numbered.png,2026-03-19 06:55:29.263778
2367,ML00003794,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3ccnc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003794_numbered.png,2026-03-19 06:55:29.325434
2368,ML00000939,CHEMBL267568,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CC(C)OC2=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000939_numbered.png,2026-03-19 06:55:29.387001
2369,ML00001892,CHEMBL1095165,,C[C@@H]1OC(=O)c2c(O)cc(C(O)(F)F)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001892_numbered.png,2026-03-19 06:55:29.422245
2370,ML00004755,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004755_numbered.png,2026-03-19 06:55:29.483683
2371,ML00002889,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2CC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002889_numbered.png,2026-03-19 06:55:29.548369
2372,ML00004319,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2ccc(-c3nnn(C)n3)s2)C[C@@H](C)/C(=N\OC)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004319_numbered.png,2026-03-19 06:55:29.612702
2373,ML00003023,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3ccccc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2374,ML00007416,,,CC[C@H](/C=C(\C)[C@@H]1C[C@@H](OC)C[C@H](O)C(C)(C)[C@@]2(O)O[C@@H](C[C@@H](OC)[C@H](O)C(=O)O1)C[C@@H](OC)[C@H]2O)CO,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2375,ML00006259,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006259_numbered.png,2026-03-19 06:55:29.701765
2376,ML00006952,,,CC(C)(C)[C@H]1COC(=O)CCCC/C=C\C[C@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2377,ML00001602,CHEMBL574429,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001602_numbered.png,2026-03-19 06:55:29.780544
2378,ML00002975,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@H]4C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2379,ML00001079,CHEMBL1080987,,O=C(C[C@H]1C/C=C/CCCCC(=O)OCCNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2380,ML00002895,,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)N/C=C/c2ccc(-c3cccnc3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002895_numbered.png,2026-03-19 06:55:29.863073
2381,ML00003563,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(Cc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003563_numbered.png,2026-03-19 06:55:29.924750
2382,ML00008370,,,COc1cc(O)cc2c1C(=O)O[C@@H](C)CCCC(=O)CCCCC2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008370_numbered.png,2026-03-19 06:55:29.952424
2383,ML00009658,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2384,ML00003729,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C3CC3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003729_numbered.png,2026-03-19 06:55:30.029091
2385,ML00002250,,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)N/C=C/c2ccc3cccnc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002250_numbered.png,2026-03-19 06:55:30.090695
2386,ML00007962,,,C[C@H]1C/C=C/[C@@H](O)[C@@H](O)CCC(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 11]",ring_size_14/standard/numbered/ML00007962_numbered.png,2026-03-19 06:55:30.126447
2387,ML00006790,,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)N2CCC(O)CC2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00006790_numbered.png,2026-03-19 06:55:30.155450
2388,ML00002950,,,CCCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002950_numbered.png,2026-03-19 06:55:30.228216
2389,ML00007815,,,C[C@@H]1C[C@@H]2O[C@H]2/C=C\C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007815_numbered.png,2026-03-19 06:55:30.256695
2390,ML00008725,,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@@H](O)C(=O)/C=C/C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008725_numbered.png,2026-03-19 06:55:30.288541
2391,ML00001624,CHEMBL273535,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)O[C@H](C)[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001624_numbered.png,2026-03-19 06:55:30.348781
2392,ML00004122,,,C=CCO[C@@H]1C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccc2Cl)[C@H](C)[C@H]1OC1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004122_numbered.png,2026-03-19 06:55:30.407757
2393,ML00002466,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)C(=NC(C)=O)[C@H](C)C(OC/C(=N/OCc3ccccc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002466_numbered.png,2026-03-19 06:55:30.470929
2394,ML00004829,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(-c5ccccc5Cl)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004829_numbered.png,2026-03-19 06:55:30.552577
2395,ML00001623,CHEMBL418256,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001623_numbered.png,2026-03-19 06:55:30.633260
2396,ML00001054,CHEMBL3828395,,COc1cc(O)c2c(c1)/C=C/CCC[C@@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00001054_numbered.png,2026-03-19 06:55:30.661684
2397,ML00005634,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCCCc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2Cl)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005634_numbered.png,2026-03-19 06:55:30.723038
2398,ML00010607,,,CC1CCCC(=O)CCCC=Cc2cc(OC(=O)c3ccccc3)cc(OC(=O)c3ccccc3)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010607_numbered.png,2026-03-19 06:55:30.751770
2399,ML00010487,,,CC(=O)OC[C@]12[C@H](O)C(=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2400,ML00003136,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cccc3ccccc23)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003136_numbered.png,2026-03-19 06:55:30.827419
2401,ML00001986,CHEMBL488623,,C/C1=C/[C@@H](C)[C@H](O)[C@@H](O)/C=C/CC/C=C/C(=O)O[C@@H]1[C@H](C)C(=O)CCCC1CC(=O)NC(=O)C1,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 6, 7, 8]",ring_size_14/standard/numbered/ML00001986_numbered.png,2026-03-19 06:55:30.869247
2402,ML00003903,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CCc2cccc(OC)c2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003903_numbered.png,2026-03-19 06:55:30.943715
2403,ML00000110,CHEMBL1801950,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C/C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00000110_numbered.png,2026-03-19 06:55:30.979488
2404,ML00004164,,,CCN[C@@H]1[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004164_numbered.png,2026-03-19 06:55:31.052641
2405,ML00004609,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](OC(=O)CCCc3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004609_numbered.png,2026-03-19 06:55:31.136213
2406,ML00001075,CHEMBL3827166,,CCC(=O)Oc1cc(O)c2c(c1)/C=C/CCC[C@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00001075_numbered.png,2026-03-19 06:55:31.166938
2407,ML00006356,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2C(NC(=O)CCCCc3cnc4ccc(OC)cc4c3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006356_numbered.png,2026-03-19 06:55:31.232010
2408,ML00001617,CHEMBL582872,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC2CCOCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001617_numbered.png,2026-03-19 06:55:31.303934
2409,ML00003884,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCc2ccc(OC)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003884_numbered.png,2026-03-19 06:55:31.371855
2410,ML00008707,,,COc1cc(O)c2c(c1Br)C(=O)O[C@H](C)C(=O)NCC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2411,ML00007548,,,CC[C@H](/C=C(\C)[C@@H]1C[C@@H](OC)C[C@H](O)C(C)(C)C2=C[C@H](O)C[C@H](C[C@@H](O)[C@H](O)C(=O)O1)O2)CO,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2412,ML00002172,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\Oc3ccc(-c4nnc(N)s4)cc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002172_numbered.png,2026-03-19 06:55:31.446602
2413,ML00009747,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCCCO)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009747_numbered.png,2026-03-19 06:55:31.519776
2414,ML00003710,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003710_numbered.png,2026-03-19 06:55:31.592261
2415,ML00010447,,,COc1cc(OCC(=O)Nc2ccc3c(c2)OCCO3)cc2c1C(=O)OC(C)CCCC(=O)CCCCC2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010447_numbered.png,2026-03-19 06:55:31.619970
2416,ML00005563,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC/C(=N\OCCCCCc3ccccc3)CCO[C@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]3NC(=O)O[C@]13C)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00005563_numbered.png,2026-03-19 06:55:31.670544
2417,ML00007596,,,Cc1cc(C)cc(COc2cc(O)c3c(c2)C=CCCCC(=O)CCCC(C)OC3=O)c1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007596_numbered.png,2026-03-19 06:55:31.696964
2418,ML00002205,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(=O)c3cccnc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2419,ML00010909,,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(N)=O)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010909_numbered.png,2026-03-19 06:55:31.765472
2420,ML00000356,CHEMBL474321,MIGRASTATIN,CO[C@H]1/C=C/CC/C=C/C(=O)O[C@H]([C@H](C)C(=O)CCCC2CC(=O)NC(=O)C2)/C(C)=C\[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 6, 7, 8]",ring_size_14/standard/numbered/ML00000356_numbered.png,2026-03-19 06:55:31.804307
2421,ML00005281,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NN(C)Cc2ccccc2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005281_numbered.png,2026-03-19 06:55:31.872454
2422,ML00002968,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@H]4C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2423,ML00007589,,,CCCCCCC[C@@H]1CC(=O)N[C@H](CO)C(=O)O[C@H](CCCCCCC)CC(=O)N[C@H](CO)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2424,ML00003761,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@](C)(OC)C[C@@H](C)C(=O)/C(Cc2ccccc2)=C/[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003761_numbered.png,2026-03-19 06:55:31.948457
2425,ML00004083,,,CC(=O)OC[C@]12[C@H](O)[C@H](OC(=O)c3cccnc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2426,ML00005629,,,CCNC(=O)c1cccc(-c2cc(CO/N=C3\COC4[C@@H](C)/C(=N/C(C)=O)[C@H](C)C[C@@](C)(OC3)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@H](CC)[C@@]4(C)O)on2)n1,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005629_numbered.png,2026-03-19 06:55:32.016892
2427,ML00010171,,,COc1ccc(C2CC(=O)Oc3cc4c(c(OC)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)c(OC)c1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010171_numbered.png,2026-03-19 06:55:32.053445
2428,ML00006970,,,COc1cc(O)c2c(c1C)C(=O)OC[C@H](CO)CCC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2429,ML00002146,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CNC(=O)OCc3ccc4nccnc4c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002146_numbered.png,2026-03-19 06:55:32.137558
2430,ML00005557,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005557_numbered.png,2026-03-19 06:55:32.210109
2431,ML00002136,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CNC(=O)OCc3cnc4ccccc4c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002136_numbered.png,2026-03-19 06:55:32.280133
2432,ML00007750,,,C[C@@H]1C[C@@H]2O[C@H]2CC/C=C\C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007750_numbered.png,2026-03-19 06:55:32.307785
2433,ML00008008,,,C[C@@H]1CC[C@@H](O)/C=C/C(=O)O[C@H](C)[C@@H](O)/C=C/C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2434,ML00002966,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CNC(=O)NCc3cncc4ccccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002966_numbered.png,2026-03-19 06:55:32.374502
2435,ML00008711,,,COc1cc(O)c2c(c1)C(O)C(O)CC1OC1C(=O)/C=C/CC(C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 11, 12]",ring_size_14/standard/numbered/ML00008711_numbered.png,2026-03-19 06:55:32.407851
2436,ML00005495,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C(=O)CNCc3ccccc3)[C@@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005495_numbered.png,2026-03-19 06:55:32.474206
2437,ML00001699,CHEMBL1097698,,C[C@@H]1OC(=O)c2c(O)cc(N3CCOCC3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001699_numbered.png,2026-03-19 06:55:32.512528
2438,ML00002371,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002371_numbered.png,2026-03-19 06:55:32.571780
2439,ML00006621,,,C/C=C1\[C@H]2OC=C(C(=O)O)[C@H]1CC(=O)OC[C@@H](c1ccc(O)c(O)c1)OC[C@H]1O[C@@H](O2)[C@H](O)[C@@H](O)[C@@H]1O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2440,ML00003342,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/OC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003342_numbered.png,2026-03-19 06:55:32.648296
2441,ML00002788,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=N\OCc3cc(-c4ccccn4)no3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002788_numbered.png,2026-03-19 06:55:32.708006
2442,ML00007138,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00007138_numbered.png,2026-03-19 06:55:32.762807
2443,ML00006738,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3cccc(Cl)c3)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00006738_numbered.png,2026-03-19 06:55:32.788303
2444,ML00003021,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](OC(=O)c4ccccc4)[C@@]14O[C@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2445,ML00006470,,,CCCCC/C=C\CCCN[C@@H]1[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006470_numbered.png,2026-03-19 06:55:32.859332
2446,ML00001379,CHEMBL1671887,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)C(=O)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001379_numbered.png,2026-03-19 06:55:32.922337
2447,ML00008491,,,COc1cc(OC)c2c(c1Cl)CC(=O)/C=C\C=C/[C@@H]1O[C@H]1C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00008491_numbered.png,2026-03-19 06:55:32.947735
2448,ML00009209,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)[C@@H]2NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00009209_numbered.png,2026-03-19 06:55:33.001266
2449,ML00007490,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O)[C@](C)(O)C[C@@H](C)[C@@H]2OC(C)(C)O[C@H]([C@H]2C)C1(C)C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00007490_numbered.png,2026-03-19 06:55:33.056545
2450,ML00002974,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@H]4C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2451,ML00010509,,,COc1cc(C2CC(=O)Oc3cc4c(c(OC)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)ccc1OC(C)C,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010509_numbered.png,2026-03-19 06:55:33.089767
2452,ML00008333,,,COc1cc(O)cc2c1C(=O)O[C@@H](C)C/C=C/[C@@H](O)[C@@H](O)CC/C=C/2,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00008333_numbered.png,2026-03-19 06:55:33.117133
2453,ML00008095,,,C[C@@H]1CC(=O)C(=O)CCC(=O)O[C@H](C)C/C=C\C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2454,ML00007125,,,C[C@H]1[C@H](O)[C@@H](C)C(=O)O[C@H]([C@@H](C)O)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@]2(CO2)[C@@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 8, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00007125_numbered.png,2026-03-19 06:55:33.173656
2455,ML00010917,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(N)=O)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00010917_numbered.png,2026-03-19 06:55:33.236173
2456,ML00007904,,,CC1CCCC(O)CCC/C=C/c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007904_numbered.png,2026-03-19 06:55:33.261462
2457,ML00003663,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003663_numbered.png,2026-03-19 06:55:33.325949
2458,ML00006481,,,C/C=C/CN1C(=O)N(CCCCn2cnc(-c3cccnc3)c2)[C@@H]2[C@@H](C)C(=O)[C@H](C)C[C@](C)(OC)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@H](C)C(=O)[C@](C)(F)C(=O)O[C@H](CC)[C@]21C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00006481_numbered.png,2026-03-19 06:55:33.386985
2459,ML00003456,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccc(F)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003456_numbered.png,2026-03-19 06:55:33.451298
2460,ML00008757,,,COC1/C=C/C(C)(O)/C=C/C(=O)OC(C)C(C)CC/C=C/1C,standard_macrolactone,14.0,,,success,,6.0,"[3, 4, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00008757_numbered.png,2026-03-19 06:55:33.488677
2461,ML00004668,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NC2CCCCC2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004668_numbered.png,2026-03-19 06:55:33.548638
2462,ML00004313,,,C#CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccc3F)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004313_numbered.png,2026-03-19 06:55:33.613527
2463,ML00002251,,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)N/C=C/c2ccc3ccccc3n2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002251_numbered.png,2026-03-19 06:55:33.671035
2464,ML00002369,,,C=C[C@]12OC(=O)N(CCCCn3cnc4ncccc43)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002369_numbered.png,2026-03-19 06:55:33.727867
2465,ML00005539,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OCCNCCCOCCCNCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005539_numbered.png,2026-03-19 06:55:33.792923
2466,ML00007752,,,C[C@@H]1C/C=C\CC/C=C\C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007752_numbered.png,2026-03-19 06:55:33.819718
2467,ML00004501,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNCc2ccc([N+](=O)[O-])cc2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004501_numbered.png,2026-03-19 06:55:33.889338
2468,ML00003197,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1C(C)C(C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2469,ML00004656,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2N(NCCCc3ccnc4ccccc34)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004656_numbered.png,2026-03-19 06:55:33.956713
2470,ML00002815,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCn3cnc(-c4ccccc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00002815_numbered.png,2026-03-19 06:55:34.008915
2471,ML00003164,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(-n4cccn4)nc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00003164_numbered.png,2026-03-19 06:55:34.069010
2472,ML00002961,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002961_numbered.png,2026-03-19 06:55:34.133421
2473,ML00008466,,,CC(=O)Oc1cc(O)c2c(c1)/C=C/CCCC(=O)CCCC(C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008466_numbered.png,2026-03-19 06:55:34.157875
2474,ML00000765,CHEMBL12265,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000765_numbered.png,2026-03-19 06:55:34.213206
2475,ML00005494,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005494_numbered.png,2026-03-19 06:55:34.277957
2476,ML00004669,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004669_numbered.png,2026-03-19 06:55:34.336418
2477,ML00002858,,,CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H]2[C@@H](OC(C)=O)[C@@]34O[C@@]2(C)COC(=O)c2cccnc2C[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c2ccc(=O)n(C)c2)[C@H](OC(C)=O)[C@@]13COC(=O)C(C)C)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2478,ML00001681,CHEMBL3954863,,C[C@@H]1OC(=O)c2c(O)cc(NCCNCCO)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001681_numbered.png,2026-03-19 06:55:34.377888
2479,ML00003580,,,C=CCO[C@@H]1C[C@@H](C)C(=O)[C@H](C)[C@@]2(C)OC(=O)O[C@@H]2[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccs2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003580_numbered.png,2026-03-19 06:55:34.431992
2480,ML00004748,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4ccc5cccnc54)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004748_numbered.png,2026-03-19 06:55:34.490185
2481,ML00004436,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](C)[C@@H](OCc4ccccc4)[C@H](N(C)C)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004436_numbered.png,2026-03-19 06:55:34.558059
2482,ML00004151,,,CCCCOCCCNC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004151_numbered.png,2026-03-19 06:55:34.620846
2483,ML00007450,,,O=C1CCC2=C1[C@@H](O)OC1=C2[C@@]2(Cc3ccc(cc3)Oc3cc(ccc3O)CCOC2=O)OC1=O,non_standard_macrocycle,14.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
2484,ML00004272,,,CCOC(=O)C(C[C@H]1C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@H](CC)[C@@]2(C)OC(=O)N[C@H]12)C(=O)OCC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004272_numbered.png,2026-03-19 06:55:34.684642
2485,ML00006460,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2486,ML00001895,CHEMBL3827476,,CC(=O)Oc1cc(O)c2c(c1)/C=C/CCCC(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00001895_numbered.png,2026-03-19 06:55:34.716511
2487,ML00003147,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cnc3ccccc3c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003147_numbered.png,2026-03-19 06:55:34.772617
2488,ML00010241,,,COc1c2c(cc3c1C(c1ccc4c(c1)OCO4)CC(=O)O3)C=CCCCC(=O)CCCC(C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010241_numbered.png,2026-03-19 06:55:34.798137
2489,ML00003813,,,CCC(=O)O[C@H]1C(O[C@@H]2C(C)[C@H](O[C@H]3C[C@@](C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)[C@@](C)(O)C(O)[C@H](C)C(=O)C(C)C[C@]2(C)O)OC(C)CC1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003813_numbered.png,2026-03-19 06:55:34.860647
2490,ML00003486,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003486_numbered.png,2026-03-19 06:55:34.916917
2491,ML00001916,CHEMBL3577612,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](OCc2cn(CCNC(=N)NC(=O)NC)nn2)[C@](C)(O)C[C@@H](C)[C@@H]2OC(C)(C)O[C@H]([C@H]2C)C1(C)C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001916_numbered.png,2026-03-19 06:55:34.971801
2492,ML00007056,,,CC[C@H](C)[C@]1(O)CC(=O)O[C@H](C)[C@@](O)(CC)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2493,ML00006740,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3ccccc3F)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00006740_numbered.png,2026-03-19 06:55:35.002652
2494,ML00004499,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)(CN(C)C)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3ccc(-c4cn(CCCCCCC(=O)NO)nn4)cc3)C2O)C(C)(OC)CC(C)C(=O)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004499_numbered.png,2026-03-19 06:55:35.067474
2495,ML00003751,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccc([N+](=O)[O-])cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003751_numbered.png,2026-03-19 06:55:35.132050
2496,ML00002024,CHEMBL3963562,,COCCOCCOCCNCNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00002024_numbered.png,2026-03-19 06:55:35.166270
2497,ML00008011,,,CC1CCCCCCCCCCC(=O)OC1,standard_macrolactone,14.0,,,success,,1.0,[4],ring_size_14/standard/numbered/ML00008011_numbered.png,2026-03-19 06:55:35.187567
2498,ML00010804,,,COc1c2c(cc3c1C(C1=Cc4ccccc4OC1)CC(=O)O3)C=CCCCC(=O)CCCC(C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010804_numbered.png,2026-03-19 06:55:35.212368
2499,ML00000316,CHEMBL4065704,,C=C1NCC(C)C(CCC(C)C(=O)/C=C/C(C)=C/CCC(C)CCCCCC)OC(=O)C(CCC(N)=O)NC(=O)C(C)CNC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2500,ML00004113,,,CC(=O)OC[C@@]12[C@@H](OC(C)=O)[C@H](O)[C@H]3OC(=O)[C@@H](C)[C@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@]1([C@H](OC(C)=O)[C@@H]4[C@@H](OC(C)=O)[C@@H]2OC(=O)C(C)(C)OC(C)=O)[C@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2501,ML00002253,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)o2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002253_numbered.png,2026-03-19 06:55:35.285371
2502,ML00008706,,,COc1cc(O)c2c(c1Br)C(=O)O[C@H](C)C(=O)NCC(=S)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2503,ML00000243,CHEMBL83305,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)Nc2cccnc2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000243_numbered.png,2026-03-19 06:55:35.317803
2504,ML00007575,,,O=C(C[C@H]1C/C=C/CCCCC(=O)O[C@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2505,ML00007924,,,C[C@@H]1CCCC(=O)CCC/C=C\c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007924_numbered.png,2026-03-19 06:55:35.347446
2506,ML00009798,,,C=C1NC[C@H](C)[C@H](CC[C@@H](C)C(=O)/C=C/C(C)=C\CC[C@@H](C)CCCCCC)OC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](C)CNC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2507,ML00005601,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=N/Oc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005601_numbered.png,2026-03-19 06:55:35.418627
2508,ML00004331,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccc3c(c2)OCO3)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004331_numbered.png,2026-03-19 06:55:35.482104
2509,ML00002872,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#CCc2ccc(-c3cnccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002872_numbered.png,2026-03-19 06:55:35.539548
2510,ML00001656,CHEMBL1269443,,CCCNC(=S)NCCO[C@H]1[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001656_numbered.png,2026-03-19 06:55:35.603949
2511,ML00010210,,,CCCCCC/C=C\C[C@@H]1CC(=O)N[C@@H](CO)C(=O)O[C@H](CCCCCCC)CC(=O)N[C@@H](CO)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2512,ML00009813,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](Oc2ccccc2[N+](=O)[O-])[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)C2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009813_numbered.png,2026-03-19 06:55:35.673443
2513,ML00007742,,,C[C@H]1C/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C\c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00007742_numbered.png,2026-03-19 06:55:35.704922
2514,ML00005965,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O[C@H]2C[C@@H](N(C)C)[C@@H](O)[C@H](C)O2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005965_numbered.png,2026-03-19 06:55:35.770511
2515,ML00006729,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3ccc(Br)cc3F)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00006729_numbered.png,2026-03-19 06:55:35.794928
2516,ML00001853,CHEMBL1099077,,C[C@@H]1OC(=O)c2c(O)cc3c(ncn3C)c2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001853_numbered.png,2026-03-19 06:55:35.829224
2517,ML00001975,CHEMBL3577620,,C#CCO[C@@H]1[C@@H](C)[C@H](OC(=O)NCCCNC(=N)NC(=O)NC)[C@@H](C)C(=O)O[C@H](CC)C(C)(C)[C@@H]2OC(C)(C)O[C@H]([C@@H]2C)[C@H](C)C[C@@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001975_numbered.png,2026-03-19 06:55:35.887454
2518,ML00002559,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](n2cccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002559_numbered.png,2026-03-19 06:55:35.955934
2519,ML00007667,,,C[C@H]1C[C@@]2(CO2)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@H](O)[C@@H](O)[C@H](C)O2)[C@H](C)[C@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00007667_numbered.png,2026-03-19 06:55:36.007787
2520,ML00006203,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCSc3nc4ccc(OC)nc4[nH]3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006203_numbered.png,2026-03-19 06:55:36.065634
2521,ML00008492,,,COc1cc(OC)c2c(c1Cl)CC(=O)/C=C/C=C\[C@H]1O[C@@H]1C[C@@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00008492_numbered.png,2026-03-19 06:55:36.091411
2522,ML00006056,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCCNCCCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006056_numbered.png,2026-03-19 06:55:36.155771
2523,ML00003809,,,CCC(=O)OC1C(OC2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)C(C)(O)C(O)C(C)C(=O)C(C)CC2(C)O)OC(C)CC1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003809_numbered.png,2026-03-19 06:55:36.219043
2524,ML00003024,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2525,ML00010222,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010222_numbered.png,2026-03-19 06:55:36.282371
2526,ML00010219,,,CCCCCCCCC[C@@H]1CC(=O)N[C@@H](CO)C(=O)O[C@H](CCCCCCC)CC(=O)N[C@@H](CO)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2527,ML00004678,,,CCCCCCCCCCCCCCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004678_numbered.png,2026-03-19 06:55:36.358730
2528,ML00007572,,,C=Cc1ccc(COc2cc(O)c3c(c2)C=CCCCC(=O)CCCC(C)OC3=O)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007572_numbered.png,2026-03-19 06:55:36.384155
2529,ML00003126,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC2CC2c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003126_numbered.png,2026-03-19 06:55:36.442763
2530,ML00006124,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)C(C)C)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3cccnn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006124_numbered.png,2026-03-19 06:55:36.503318
2531,ML00009146,,,COC(=O)c1ccc(-c2ccc(C3CC(=O)Oc4cc5c(c(OC)c43)C(=O)OC(C)CCCC(=O)CCCC=C5)o2)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00009146_numbered.png,2026-03-19 06:55:36.529451
2532,ML00005612,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2OC(=O)c1ccccc1)[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2533,ML00007954,,,C[C@@H]1C[C@H]2O[C@H]2CCCC[C@H](O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007954_numbered.png,2026-03-19 06:55:36.563272
2534,ML00000804,CHEMBL583091,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4ccnc5ncccc45)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000804_numbered.png,2026-03-19 06:55:36.620238
2535,ML00005497,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005497_numbered.png,2026-03-19 06:55:36.685608
2536,ML00009740,,,CO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@@H](C)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009740_numbered.png,2026-03-19 06:55:36.743362
2537,ML00008367,,,COc1cc(O)cc2c1C(=O)O[C@@H](C)CCCCCCCC(=O)C2,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00008367_numbered.png,2026-03-19 06:55:36.769505
2538,ML00010777,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@](C)(O)[C@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,14.0,"[3, 4, 4, 5, 6, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010777_numbered.png,2026-03-19 06:55:36.834338
2539,ML00001675,CHEMBL3914342,,C[C@@H]1OC(=O)c2c(O)cc(NCC(=O)N(C)C)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001675_numbered.png,2026-03-19 06:55:36.869235
2540,ML00004870,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc(-c5ccnc(N)c5)c4)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004870_numbered.png,2026-03-19 06:55:36.927601
2541,ML00001337,CHEMBL1256554,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001337_numbered.png,2026-03-19 06:55:36.988652
2542,ML00003656,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2543,ML00007776,,,C/C1=C/CC[C@H](C)[C@@H](C)OC(=O)/C=C\[C@](C)(O)/C=C\[C@@H]1O,standard_macrolactone,14.0,,,success,,6.0,"[3, 4, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00007776_numbered.png,2026-03-19 06:55:37.033978
2544,ML00007999,,,C[C@@H]1CCC/C=C\C/C=C\CCCC(=O)O1,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00007999_numbered.png,2026-03-19 06:55:37.055166
2545,ML00009655,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2546,ML00000770,CHEMBL3314701,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2547,ML00002463,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccc(F)c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002463_numbered.png,2026-03-19 06:55:37.133445
2548,ML00008560,,,CC[C@@H]1OC(=O)CCCC/C=C\C/C=C\[C@H]2[C@H]1C[C@@H]1O[C@@H]12,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008560_numbered.png,2026-03-19 06:55:37.155901
2549,ML00001885,CHEMBL4072401,,COc1cc(O)c2c(c1)CCC[C@H](O)[C@H](O)[C@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001885_numbered.png,2026-03-19 06:55:37.186166
2550,ML00001275,CHEMBL3335485,,CC[C@H]1OC(=O)[C@H](C)C(=O)C[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 13, 14]",ring_size_14/standard/numbered/ML00001275_numbered.png,2026-03-19 06:55:37.238284
2551,ML00003227,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc3ncccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00003227_numbered.png,2026-03-19 06:55:37.299856
2552,ML00005361,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@](C)(OC)[C@H]2OC(=O)CCOCCOCCCc2ccc3c(c2)c(=O)c(C(=O)O)cn3CC)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005361_numbered.png,2026-03-19 06:55:37.368520
2553,ML00003676,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCCNCCCn2ccnc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003676_numbered.png,2026-03-19 06:55:37.430869
2554,ML00010776,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010776_numbered.png,2026-03-19 06:55:37.493313
2555,ML00006935,,,C[C@H]1C[C@@]2(CO2)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C)OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006935_numbered.png,2026-03-19 06:55:37.543893
2556,ML00009069,,,C=CCO[C@]1(C)C[C@@H](C)C2=NCCN3C(=O)O[C@](C)([C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009069_numbered.png,2026-03-19 06:55:37.596840
2557,ML00002163,,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)N/C=C/c2ccc(-n3cccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002163_numbered.png,2026-03-19 06:55:37.654095
2558,ML00004337,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccc(F)cc3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004337_numbered.png,2026-03-19 06:55:37.735274
2559,ML00007084,,,COC1C=CC(C)(O)C(SCC(N)C(=O)O)CC(=O)OC(C)C(C)CCC=C1C,standard_macrolactone,14.0,,,success,,7.0,"[3, 4, 8, 9, 12, 12, 13]",ring_size_14/standard/numbered/ML00007084_numbered.png,2026-03-19 06:55:37.783953
2560,ML00003156,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4c(OC)cnc5ncccc45)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003156_numbered.png,2026-03-19 06:55:37.845900
2561,ML00001840,CHEMBL550998,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\[C@H](O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00001840_numbered.png,2026-03-19 06:55:37.903639
2562,ML00007744,,,C[C@H]1CCCC(=O)C(=O)C(=O)CCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00007744_numbered.png,2026-03-19 06:55:37.938743
2563,ML00002181,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)C[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cc(-c4cccc(N)c4)nn3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002181_numbered.png,2026-03-19 06:55:37.998748
2564,ML00007894,,,C[C@H]1CCC[C@@H](O)[C@@H](O)CCC(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 11]",ring_size_14/standard/numbered/ML00007894_numbered.png,2026-03-19 06:55:38.031286
2565,ML00003005,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2566,ML00006067,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CC2CC2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006067_numbered.png,2026-03-19 06:55:38.100234
2567,ML00005643,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2C(NC(=O)CCCCc3cnc4ccccc4c3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005643_numbered.png,2026-03-19 06:55:38.158672
2568,ML00008738,,,COc1cc(O)c(Cl)c2c1C(=O)O[C@H](C)CCC(=O)CC/C=C\C(=O)C2,standard_macrolactone,14.0,,,success,,3.0,"[3, 6, 11]",ring_size_14/standard/numbered/ML00008738_numbered.png,2026-03-19 06:55:38.187206
2569,ML00005707,,,CC[C@@H](C)C(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2570,ML00008383,,,COc1cc(O)c2c(c1)/C=C/CCCC(O)C[C@H](Cl)C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 5, 7]",ring_size_14/standard/numbered/ML00008383_numbered.png,2026-03-19 06:55:38.222387
2571,ML00000932,CHEMBL268491,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CC(C)C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000932_numbered.png,2026-03-19 06:55:38.279307
2572,ML00007108,,,CC[C@@H]1OC(=O)[C@H](C)[C@H](O)[C@H](C)C(=O)[C@](C)(O)C[C@@H](C)C(=O)[C@@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00007108_numbered.png,2026-03-19 06:55:38.335735
2573,ML00007570,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1ccc(O)cc1)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007570_numbered.png,2026-03-19 06:55:38.361291
2574,ML00007142,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00007142_numbered.png,2026-03-19 06:55:38.424787
2575,ML00007780,,,C[C@H]1CC/C=C(/CO)[C@@H](O)/C=C\[C@@](C)(O)/C=C\C(=O)O[C@@H]1C,standard_macrolactone,14.0,,,success,,6.0,"[3, 4, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00007780_numbered.png,2026-03-19 06:55:38.462339
2576,ML00001808,CHEMBL3629242,,COc1cc(O)c2c(c1Br)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001808_numbered.png,2026-03-19 06:55:38.493302
2577,ML00007059,,,CC(C)[C@@]1(O)CC(=O)O[C@H](C)[C@](O)(C(C)C)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2578,ML00004334,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCOc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004334_numbered.png,2026-03-19 06:55:38.551992
2579,ML00000109,CHEMBL1596863,,CC1CC2OC2/C=C\C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000109_numbered.png,2026-03-19 06:55:38.576883
2580,ML00008530,,,COc1cc(OC)c2c(c1Cl)CC(=O)CCCC/C=C/CC(C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00008530_numbered.png,2026-03-19 06:55:38.601235
2581,ML00000075,CHEMBL1553635,,COC(=O)NC/C=C\c1nc(CC/C=C\C(=O)O[C@H]2C[C@H]3CC(=O)O[C@@H](/C=C\CC(C)C)C[C@@H]4CC[C@H](C)[C@H](C[C@@H](OC)C[C@H](C2)O3)O4)co1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2582,ML00009836,,,CC[C@H]1OC(=O)[C@@H](C)[C@@H](O[C@H]2C[C@@H](OC)[C@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@](C)(O)C[C@@]2(CO2)C(=O)[C@H](C)[C@@H](O)[C@@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009836_numbered.png,2026-03-19 06:55:38.664662
2583,ML00003283,,,CC[C@H]1OC(=O)[C@@](C)(F)[C@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00003283_numbered.png,2026-03-19 06:55:38.725605
2584,ML00006543,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CCc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006543_numbered.png,2026-03-19 06:55:38.790602
2585,ML00010910,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00010910_numbered.png,2026-03-19 06:55:38.843894
2586,ML00001088,CHEMBL1078263,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H](OC)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001088_numbered.png,2026-03-19 06:55:38.879533
2587,ML00003121,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4ccc5ncccc5c4)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003121_numbered.png,2026-03-19 06:55:38.935214
2588,ML00001207,CHEMBL1778046,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001207_numbered.png,2026-03-19 06:55:38.999383
2589,ML00001903,CHEMBL3950457,,C[C@@H]1OC(=O)c2c(O)cc(NCC(=O)O)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001903_numbered.png,2026-03-19 06:55:39.033363
2590,ML00001067,CHEMBL1094695,PAECILOMYCIN F,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)[C@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001067_numbered.png,2026-03-19 06:55:39.065757
2591,ML00004506,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)(CN(C)Cc3ccc(-c4cn(CCCCCCC(=O)NO)nn4)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(OC)CC(C)C(=O)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004506_numbered.png,2026-03-19 06:55:39.154786
2592,ML00002151,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2ccc3ccccc3n2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002151_numbered.png,2026-03-19 06:55:39.213467
2593,ML00000189,CHEMBL1557202,,CC[C@@H]1OC(=O)[C@H](C)[C@H](O[C@@H]2C[C@](C)(OC)[C@H](O)[C@H](C)O2)[C@H](C)[C@H](O[C@@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@H](C)/C(=N\OCOCCOC)[C@H](C)[C@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000189_numbered.png,2026-03-19 06:55:39.279019
2594,ML00000549,CHEMBL273387,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000549_numbered.png,2026-03-19 06:55:39.339108
2595,ML00003299,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cccnc2)[C@H](C)[C@@H]2OC(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003299_numbered.png,2026-03-19 06:55:39.396772
2596,ML00007105,,,C=C1/C=C(/C)[C@H](CC)OC(=O)[C@H](C)C(=O)[C@](O)(CO)C/C(OC)=C\[C@@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00007105_numbered.png,2026-03-19 06:55:39.445025
2597,ML00002825,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3ccc4ccccc43)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002825_numbered.png,2026-03-19 06:55:39.500826
2598,ML00003952,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2599,ML00001587,CHEMBL575518,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NOC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001587_numbered.png,2026-03-19 06:55:39.572972
2600,ML00009854,,,CC[C@H]1OC(=O)[C@H](C)C2O[C@@](C)(C[C@@H](C)CN(C(=O)Nc3ccc(Cl)cc3Cl)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2601,ML00006030,,,CCCCCNC(=O)CCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006030_numbered.png,2026-03-19 06:55:39.644460
2602,ML00004833,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc(-c5cccc(N)c5)c4)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004833_numbered.png,2026-03-19 06:55:39.704117
2603,ML00002449,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00002449_numbered.png,2026-03-19 06:55:39.756758
2604,ML00001477,CHEMBL1269438,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCNC(=O)c2ccc3[nH]cnc3c2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001477_numbered.png,2026-03-19 06:55:39.822307
2605,ML00006346,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N(C)C)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006346_numbered.png,2026-03-19 06:55:39.881237
2606,ML00008954,,,C=C1COC2[C@@H](C)/C(=N/OCOC)[C@H](C)C[C@@](C)(OC1)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@H](CC)[C@@]2(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00008954_numbered.png,2026-03-19 06:55:39.937813
2607,ML00004878,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N(C)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004878_numbered.png,2026-03-19 06:55:40.026131
2608,ML00003175,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccc3ncccc3c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00003175_numbered.png,2026-03-19 06:55:40.088702
2609,ML00005923,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4c(OC)ccc5ccccc45)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005923_numbered.png,2026-03-19 06:55:40.146453
2610,ML00002765,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(-n4cccn4)nc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002765_numbered.png,2026-03-19 06:55:40.204076
2611,ML00008390,,,COc1cc(O)c2c(c1)CCCC(=O)C(=O)C(O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008390_numbered.png,2026-03-19 06:55:40.235381
2612,ML00007987,,,C[C@@H]1CCCCCCCCCCC(=O)OC1,standard_macrolactone,14.0,,,success,,1.0,[4],ring_size_14/standard/numbered/ML00007987_numbered.png,2026-03-19 06:55:40.256862
2613,ML00008097,,,C[C@H]1CC[C@H](O)/C=C\C(=O)O[C@@H](C)C(=O)/C=C\C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2614,ML00007368,,,C/C(=C\c1csc(C)n1)[C@@H](O)C[C@H]1OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC[C@@]1(C)O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 4, 8, 9, 10, 11, 12, 12, 13]",ring_size_14/standard/numbered/ML00007368_numbered.png,2026-03-19 06:55:40.312423
2615,ML00004746,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cncc4-c4ccco4)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004746_numbered.png,2026-03-19 06:55:40.371928
2616,ML00002359,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCn1ccc2c(N)cccc21,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002359_numbered.png,2026-03-19 06:55:40.428684
2617,ML00007932,,,C[C@@H]1C[C@H]2O[C@H]2C/C=C/C[C@H](O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007932_numbered.png,2026-03-19 06:55:40.459813
2618,ML00009653,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@H]4C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2619,ML00003481,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCOc3ccncc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003481_numbered.png,2026-03-19 06:55:40.543772
2620,ML00009432,,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)Nc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009432_numbered.png,2026-03-19 06:55:40.602814
2621,ML00006195,,,CCCCCCCCCCCCN[C@@H]1[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006195_numbered.png,2026-03-19 06:55:40.667520
2622,ML00003344,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCCCOC(C)C)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003344_numbered.png,2026-03-19 06:55:40.731626
2623,ML00001289,CHEMBL1256556,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001289_numbered.png,2026-03-19 06:55:40.792394
2624,ML00004127,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2ccc3[nH]cnc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004127_numbered.png,2026-03-19 06:55:40.881288
2625,ML00007441,,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)N2CCC(C(N)=O)CC2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007441_numbered.png,2026-03-19 06:55:40.909315
2626,ML00006415,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NC(C)CCCN(CC)CC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006415_numbered.png,2026-03-19 06:55:40.975234
2627,ML00004722,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]4O)[C@H](O)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004722_numbered.png,2026-03-19 06:55:41.045769
2628,ML00003081,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NCCC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003081_numbered.png,2026-03-19 06:55:41.110066
2629,ML00004575,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNc2ccccc2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004575_numbered.png,2026-03-19 06:55:41.176430
2630,ML00006516,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)CCNC(=O)OC(C)(C)C)[C@@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006516_numbered.png,2026-03-19 06:55:41.241873
2631,ML00002318,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)C(C)C)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002318_numbered.png,2026-03-19 06:55:41.305745
2632,ML00006528,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]cnc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006528_numbered.png,2026-03-19 06:55:41.371821
2633,ML00005807,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC2CCCN(CCCc3ccc(O)cc3)C2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005807_numbered.png,2026-03-19 06:55:41.434708
2634,ML00001567,CHEMBL582869,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC2CC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001567_numbered.png,2026-03-19 06:55:41.499213
2635,ML00002239,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2ccc3cccnc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002239_numbered.png,2026-03-19 06:55:41.556250
2636,ML00003999,,,CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H]2[C@@H](OC(C)=O)[C@@]34O[C@@]2(C)COC(=O)c2cccnc2[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]13COC(=O)c1ccco1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2637,ML00010477,,,O=C1CCCC/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2638,ML00010201,,,COC(=O)c1ccc(C2CC(=O)Oc3cc4c(c(OC)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010201_numbered.png,2026-03-19 06:55:41.594765
2639,ML00003139,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccc(-n3ccnc3)cc2)[C@H](C)[C@@H]2OC(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003139_numbered.png,2026-03-19 06:55:41.650820
2640,ML00006082,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCC#Cc2cnc3ccccc3c2)[C@H](C)[C@@H](O[C@@H]2OCC[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2Cl)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006082_numbered.png,2026-03-19 06:55:41.708470
2641,ML00006204,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CCCCCc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006204_numbered.png,2026-03-19 06:55:41.771997
2642,ML00003154,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN([C@@H](C)c4ccnc5ncccc45)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003154_numbered.png,2026-03-19 06:55:41.828738
2643,ML00007931,,,C[C@@H]1C[C@H]2O[C@H]2C/C=C/C[C@@H](O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007931_numbered.png,2026-03-19 06:55:41.853965
2644,ML00002720,,,C=CCOC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H]4[C@H]3OC(=O)N4C)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]3OC(=O)O[C@]3(C)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002720_numbered.png,2026-03-19 06:55:41.912504
2645,ML00008943,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N/OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00008943_numbered.png,2026-03-19 06:55:41.974118
2646,ML00002663,,,CO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](OC(C)=O)[C@@H](C)C(=O)[C@]3(CO3)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@@H]3OC(C)=O)[C@H]2C)O[C@@H](C)[C@H]1OC(C)=O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002663_numbered.png,2026-03-19 06:55:42.029571
2647,ML00003749,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O/C=C\Cc2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\O)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003749_numbered.png,2026-03-19 06:55:42.086704
2648,ML00009089,,,CCOC(=O)C1NN=CC12[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2O,standard_macrolactone,14.0,,,success,,11.0,"[3, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009089_numbered.png,2026-03-19 06:55:42.142513
2649,ML00005879,,,C=C[C@]12OC(=O)N(CCCCn3ccc4c(N)cccc43)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005879_numbered.png,2026-03-19 06:55:42.198554
2650,ML00001065,CHEMBL125990,,CN(C)CC1CCCC(=O)OC[C@H](NC(=O)C(Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC2CCCCC2)[C@@H](O)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2651,ML00010770,,,CC[C@H]1OC(=O)[C@H](C)C[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00010770_numbered.png,2026-03-19 06:55:42.263797
2652,ML00008388,,,COc1cc(O)c2c(c1)[C@H]1O[C@@H]1C[C@H](O)[C@H](O)[C@@H](O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008388_numbered.png,2026-03-19 06:55:42.295806
2653,ML00003246,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NCc2cn(-c3ncccn3)cn2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00003246_numbered.png,2026-03-19 06:55:42.356356
2654,ML00004616,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004616_numbered.png,2026-03-19 06:55:42.422913
2655,ML00005912,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2cccc(-c3ncccn3)c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2CC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005912_numbered.png,2026-03-19 06:55:42.481208
2656,ML00007748,,,COc1cc(O)c2c(c1Br)C(=O)OCCNCC(=S)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2657,ML00003278,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003278_numbered.png,2026-03-19 06:55:42.540464
2658,ML00001809,CHEMBL3334710,,COc1cc(O)c(Cl)c2c1C(=O)O[C@@H](C)CCC(=O)CC/C=C/C(=O)C2,standard_macrolactone,14.0,,,success,,3.0,"[3, 6, 11]",ring_size_14/standard/numbered/ML00001809_numbered.png,2026-03-19 06:55:42.569138
2659,ML00003472,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3ccc(SC)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003472_numbered.png,2026-03-19 06:55:42.621955
2660,ML00007828,,,C[C@H]1CCC[C@@H](C)[C@@H](O)/C=C\[C@@](C)(O)CCC(=O)O[C@@H]1C,standard_macrolactone,14.0,,,success,,6.0,"[3, 4, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00007828_numbered.png,2026-03-19 06:55:42.659192
2661,ML00008392,,,COc1cc(O)c2c(c1)/C=C\C[C@H](O)[C@H](O)C(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008392_numbered.png,2026-03-19 06:55:42.690058
2662,ML00009610,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3cccnc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00009610_numbered.png,2026-03-19 06:55:42.742132
2663,ML00001781,CHEMBL3956374,,C[C@@H]1OC(=O)c2c(O)cc(NCC3CCNCC3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001781_numbered.png,2026-03-19 06:55:42.776004
2664,ML00005745,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCC#Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2Cl)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005745_numbered.png,2026-03-19 06:55:42.834155
2665,ML00009586,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCC#Cc2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009586_numbered.png,2026-03-19 06:55:42.897665
2666,ML00009114,,,CC[C@H]1OC(=O)[C@H](C)C2(O)O[C@@](C)(C[C@@H](C)CN(C(=O)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2667,ML00006361,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2C(NC(=O)/C=C/CCc3cnc4c(OC)cccc4c3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006361_numbered.png,2026-03-19 06:55:42.960989
2668,ML00009457,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@H](OC)[C@@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009457_numbered.png,2026-03-19 06:55:43.022104
2669,ML00008005,,,C[C@@H]1C/C=C\C(=O)O[C@H](C)C[C@H](O)[C@H](O)/C=C\C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2670,ML00002196,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCn1cnc(-c2ccc(Cl)nc2)c1,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002196_numbered.png,2026-03-19 06:55:43.081282
2671,ML00005841,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCNC(=O)OCc3cnc4ccccc4c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005841_numbered.png,2026-03-19 06:55:43.137000
2672,ML00001242,CHEMBL1256545,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001242_numbered.png,2026-03-19 06:55:43.200726
2673,ML00008002,,,CC1COC(=O)C(C)NC(=O)C(C)COC(=O)C(C)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2674,ML00002487,,,C/C=C(\C)C(=O)O[C@H]1[C@@H](OC(C)=O)[C@@H]2OC(=O)[C@@H](C)[C@H](C)c3ncccc3C(=O)OC[C@]3(C)O[C@@]4([C@H](OC(C)=O)[C@H]3[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@]14COC(C)=O)[C@@]2(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2675,ML00001314,CHEMBL1671888,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)/C(=N/OCOCCOC)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001314_numbered.png,2026-03-19 06:55:43.276445
2676,ML00001807,CHEMBL3629245,,COc1cc2c(c(O)c1Br)C(=O)O[C@@H](C)C/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/2,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001807_numbered.png,2026-03-19 06:55:43.307640
2677,ML00002444,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C/C=C/Cn3cnc4cccnc43)C(=O)N[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002444_numbered.png,2026-03-19 06:55:43.362995
2678,ML00003304,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Br)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003304_numbered.png,2026-03-19 06:55:43.415652
2679,ML00007757,,,C[C@H]1C/C=C\CC/C=C\C(=O)Cc2cccc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007757_numbered.png,2026-03-19 06:55:43.440731
2680,ML00007838,,,C[C@@H]1CCC=CCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007838_numbered.png,2026-03-19 06:55:43.464976
2681,ML00009444,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009444_numbered.png,2026-03-19 06:55:43.529341
2682,ML00001881,CHEMBL1801951,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001881_numbered.png,2026-03-19 06:55:43.560295
2683,ML00006572,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCSc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006572_numbered.png,2026-03-19 06:55:43.624408
2684,ML00003294,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)/C(C)=C/[C@]1(C)OC(=O)NCCCSc1ncnc2[nH]ncc12,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003294_numbered.png,2026-03-19 06:55:43.683291
2685,ML00002781,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccccc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002781_numbered.png,2026-03-19 06:55:43.747651
2686,ML00004785,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2ccc(NC(=O)Cc3ccccn3)nc2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004785_numbered.png,2026-03-19 06:55:43.810973
2687,ML00008320,,,COc1cc(O)c2c(c1)CCCCC[C@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008320_numbered.png,2026-03-19 06:55:43.837170
2688,ML00002436,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CC/C=C\c3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00002436_numbered.png,2026-03-19 06:55:43.890534
2689,ML00000015,CHEMBL1097700,,CNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00000015_numbered.png,2026-03-19 06:55:43.925442
2690,ML00002631,,,CCCc1cnc(SCCCN2C(=O)O[C@]3(C)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]4O[C@H](C)C[C@H](N(C)C)[C@H]4O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]23)nc1,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002631_numbered.png,2026-03-19 06:55:43.981279
2691,ML00004137,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC#Cc2cc(-c3cnc(N)nc3)no2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00004137_numbered.png,2026-03-19 06:55:44.041410
2692,ML00002908,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)CCCNCc3nccs3)[C@@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002908_numbered.png,2026-03-19 06:55:44.106401
2693,ML00001893,CHEMBL1098879,,COc1cc(O)c2c(c1Br)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001893_numbered.png,2026-03-19 06:55:44.141288
2694,ML00003699,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@H]2C[C@@H](N(C)C)C[C@@H](C)O2)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003699_numbered.png,2026-03-19 06:55:44.205748
2695,ML00004886,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCCC(=O)NCc3ccc(F)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004886_numbered.png,2026-03-19 06:55:44.271881
2696,ML00004569,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)(CN(C)C)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3ccc(-c4cn(CCCCCC(=O)NO)nn4)cc3)C2O)C(C)(OC)CC(C)C(=O)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004569_numbered.png,2026-03-19 06:55:44.337533
2697,ML00003480,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3ccccc3CO)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003480_numbered.png,2026-03-19 06:55:44.391069
2698,ML00001221,CHEMBL1774287,,CCCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001221_numbered.png,2026-03-19 06:55:44.455125
2699,ML00001588,CHEMBL1269444,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCNS(C)(=O)=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001588_numbered.png,2026-03-19 06:55:44.520276
2700,ML00001320,CHEMBL1256557,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001320_numbered.png,2026-03-19 06:55:44.581710
2701,ML00009708,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@@H](O)[C@H]3[C@@H](OC(C)=O)[C@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2702,ML00003402,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](c3ccoc3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003402_numbered.png,2026-03-19 06:55:44.650617
2703,ML00000639,CHEMBL3827270,,CCCOc1cc(O)c2c(c1)/C=C/CCC[C@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00000639_numbered.png,2026-03-19 06:55:44.675176
2704,ML00005723,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC/C=C/c2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2Cl)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005723_numbered.png,2026-03-19 06:55:44.733184
2705,ML00008777,,,CC[C@H]1OC(=O)CCCC/C=C\C/C=C\[C@H]2[C@H](O)[C@@H](O)C[C@H]12,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008777_numbered.png,2026-03-19 06:55:44.755697
2706,ML00004538,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](OC(=O)CCCCc3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004538_numbered.png,2026-03-19 06:55:44.821621
2707,ML00009001,,,C=C1C[C@H](C)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@H](OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009001_numbered.png,2026-03-19 06:55:44.880814
2708,ML00003660,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]3[C@H](OC(C)=O)[C@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@H]([C@@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2709,ML00003119,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4cccc5ncccc45)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003119_numbered.png,2026-03-19 06:55:44.944963
2710,ML00010778,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010778_numbered.png,2026-03-19 06:55:45.007304
2711,ML00008897,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC[C@@H](N)C(=O)OC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00008897_numbered.png,2026-03-19 06:55:45.071989
2712,ML00009418,,,CC(C)(N)CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)CCC[C@H](CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2713,ML00004493,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NN2CCCC2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004493_numbered.png,2026-03-19 06:55:45.149746
2714,ML00000696,CHEMBL1610778,,COC1C[C@@H](O[C@@H]2C(C)C(=O)OC(C)C(C)[C@H](OC(C)=O)C(C)C(=O)[C@@]3(CO3)CC(C)C(OC3OC(C)CC(N(C)C)[C@H]3OC(C)=O)C2C)OC(C)[C@@H]1OC(C)=O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000696_numbered.png,2026-03-19 06:55:45.205826
2715,ML00003608,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@H]4C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2716,ML00007968,,,C[C@@H]1C/C=C\[C@@H](O)[C@@H](O)CC/C=C\c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00007968_numbered.png,2026-03-19 06:55:45.241433
2717,ML00007764,,,C[C@@H]1C[C@@H](O)[C@H](O)/C=C\C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 6, 11]",ring_size_14/standard/numbered/ML00007764_numbered.png,2026-03-19 06:55:45.272656
2718,ML00007392,,,COc1ccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007392_numbered.png,2026-03-19 06:55:45.297556
2719,ML00003552,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)C(C)C)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2720,ML00006569,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006569_numbered.png,2026-03-19 06:55:45.369336
2721,ML00001313,CHEMBL1778051,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(N)=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001313_numbered.png,2026-03-19 06:55:45.437058
2722,ML00010269,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O)[C@](C)(O)C[C@](C)(O)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 5, 6, 7, 8, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010269_numbered.png,2026-03-19 06:55:45.504054
2723,ML00009000,,,CO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@@H](C)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009000_numbered.png,2026-03-19 06:55:45.563441
2724,ML00003502,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccc(OC)c2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003502_numbered.png,2026-03-19 06:55:45.629661
2725,ML00005660,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=C/c2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005660_numbered.png,2026-03-19 06:55:45.697939
2726,ML00002587,,,CCCCN[C@@H]1[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002587_numbered.png,2026-03-19 06:55:45.763441
2727,ML00007409,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1cc(Cl)c2c(c1)OCO2)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007409_numbered.png,2026-03-19 06:55:45.789950
2728,ML00003672,,,CO[C@]1(C)C[C@H](O[C@H]2[C@@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@H](C)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C3CC3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003672_numbered.png,2026-03-19 06:55:45.848937
2729,ML00009530,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]3NC(=O)O[C@H]32)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009530_numbered.png,2026-03-19 06:55:45.916840
2730,ML00005728,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(C)=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005728_numbered.png,2026-03-19 06:55:45.977305
2731,ML00002155,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2OCC[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#CCC2CC(c3ccccc3)=NO2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002155_numbered.png,2026-03-19 06:55:46.038249
2732,ML00005859,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CC(C)(C)C[C@@H]2c2cccc(Cl)c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005859_numbered.png,2026-03-19 06:55:46.098448
2733,ML00007741,,,C[C@@H]1CCC/C=C\[C@]2(O)CC(=O)c3c(cc(O)cc3O2)CC(=O)O1,non_standard_macrocycle,14.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
2734,ML00004288,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3ccc(NC(C)=O)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004288_numbered.png,2026-03-19 06:55:46.156925
2735,ML00007104,,,C=C1/C=C(/C)[C@H](CC)OC(=O)[C@H](C)C(=O)[C@@](O)(CO)C/C(OC)=C\[C@@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00007104_numbered.png,2026-03-19 06:55:46.204616
2736,ML00005696,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2ccc([N+](=O)[O-])nc2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005696_numbered.png,2026-03-19 06:55:46.263098
2737,ML00007837,,,COc1cc(O)c2c(c1Br)C(=O)OCCNCC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2738,ML00001244,CHEMBL1256548,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(O)CO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001244_numbered.png,2026-03-19 06:55:46.332196
2739,ML00000032,CHEMBL1668411,,COc1cc(O)c2c(c1)/C=C/C[C@@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00000032_numbered.png,2026-03-19 06:55:46.363590
2740,ML00010512,,,COc1cc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)ccc1OCC(C)C,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010512_numbered.png,2026-03-19 06:55:46.388228
2741,ML00001911,CHEMBL132146,,C=CCO[C@]1(C)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001911_numbered.png,2026-03-19 06:55:46.443271
2742,ML00008487,,,COc1cc2c(c(OC)c1)C(=O)O[C@H](C)C[C@H]1O[C@@H]1/C=C\C=C\C(=O)C2,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00008487_numbered.png,2026-03-19 06:55:46.468119
2743,ML00004323,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCn1cnc2cccnc21,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004323_numbered.png,2026-03-19 06:55:46.520369
2744,ML00009217,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009217_numbered.png,2026-03-19 06:55:46.572853
2745,ML00008700,,,CCCCC[C@@H]1CCCCC[C@H](O)C[C@@H](O)[C@@H](O)/C=C/C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 9, 11, 12]",ring_size_14/standard/numbered/ML00008700_numbered.png,2026-03-19 06:55:46.603417
2746,ML00009706,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2747,ML00004296,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004296_numbered.png,2026-03-19 06:55:46.667664
2748,ML00005744,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2cccnc2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005744_numbered.png,2026-03-19 06:55:46.726328
2749,ML00002208,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3cccnc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2750,ML00002567,,,C=CCO[C@]1(C)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002567_numbered.png,2026-03-19 06:55:46.791872
2751,ML00002433,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@H]2C[C@H](O)[C@@H](N(C)C)[C@@H](C)O2)[C@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)/C(=N\O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002433_numbered.png,2026-03-19 06:55:46.855462
2752,ML00005519,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2753,ML00002864,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccc(F)c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(F)cc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002864_numbered.png,2026-03-19 06:55:46.927780
2754,ML00008103,,,C[C@@H]1CCC(=O)/C=C/C(=O)O[C@H](C)C(=O)/C=C/C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2755,ML00009226,,,C=CCO[C@@]1(C)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009226_numbered.png,2026-03-19 06:55:46.989271
2756,ML00002225,,,CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@]2(OC(C)=O)[C@H](OC(=O)c3ccccc3)[C@H](OC(C)=O)[C@H]3OC(=O)[C@@H](C)[C@@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@]2([C@H](OC(C)=O)[C@H]14)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2757,ML00005711,,,C/C=C(\C)C(=O)O[C@H]1[C@@H](OC(=O)c2ccc(=O)n(C)c2)[C@@H]2OC(=O)[C@@H](C)[C@@H](C)c3ncccc3C(=O)OC[C@]3(C)O[C@@]4([C@H](OC(C)=O)[C@H]3[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@]14COC(C)=O)[C@]2(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2758,ML00002385,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCCNCCCCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002385_numbered.png,2026-03-19 06:55:47.066969
2759,ML00009579,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009579_numbered.png,2026-03-19 06:55:47.132123
2760,ML00009584,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009584_numbered.png,2026-03-19 06:55:47.196615
2761,ML00010170,,,Cc1ccc2ccccc2c1COc1cc(O)c2c(c1)C=CCCCC(=O)CCCC(C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010170_numbered.png,2026-03-19 06:55:47.222333
2762,ML00003854,,,CCCN[C@@H]1[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003854_numbered.png,2026-03-19 06:55:47.286720
2763,ML00004696,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCC(=O)NCCc3ccc(O)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004696_numbered.png,2026-03-19 06:55:47.365126
2764,ML00010653,,,COc1c2c(cc3c1C(c1cc4cccc5c4n(c1=O)CC5)CC(=O)O3)C=CCCCC(=O)CCCC(C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010653_numbered.png,2026-03-19 06:55:47.392180
2765,ML00007743,,,C[C@@H]1C[C@@H]2O[C@H]2C[C@@H](O)/C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 8, 11]",ring_size_14/standard/numbered/ML00007743_numbered.png,2026-03-19 06:55:47.421264
2766,ML00001278,CHEMBL339289,,CC(C)(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)CCC[C@H](CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O)NC(=O)OC(C)(C)C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2767,ML00010574,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(N)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00010574_numbered.png,2026-03-19 06:55:47.491093
2768,ML00001793,CHEMBL2012390,,C[C@H]1CCC[C@@H](O)[C@@H](O)CC/C=C/c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00001793_numbered.png,2026-03-19 06:55:47.519447
2769,ML00005654,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC(=O)CCCOc3ccc([N+](=O)[O-])cc3OC)[C@H]2O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005654_numbered.png,2026-03-19 06:55:47.583768
2770,ML00006173,,,CCCCCNC(=O)CO[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006173_numbered.png,2026-03-19 06:55:47.646972
2771,ML00005792,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005792_numbered.png,2026-03-19 06:55:47.712195
2772,ML00001484,CHEMBL288534,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001484_numbered.png,2026-03-19 06:55:47.771687
2773,ML00009711,,,CC(=O)OC[C@@]12[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(=O)[C@H](C)[C@@H](C)c4ccncc4C(=O)OC[C@@]4(C)O[C@]1([C@H](O)[C@@H]4[C@@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2774,ML00005825,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4ccc(Cl)cc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005825_numbered.png,2026-03-19 06:55:47.836165
2775,ML00008098,,,C[C@@H]1CC[C@@H](O)/C=C/C(=O)O[C@H](C)C(=O)/C=C/C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2776,ML00007458,,,O=C(C[C@H]1C/C=C\CCCCC(=O)OC[C@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2777,ML00003462,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccc(F)c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003462_numbered.png,2026-03-19 06:55:47.912301
2778,ML00008321,,,COc1cc(O)c2c(c1)CCCCC[C@@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008321_numbered.png,2026-03-19 06:55:47.936871
2779,ML00003454,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCC(=O)NCc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003454_numbered.png,2026-03-19 06:55:47.999304
2780,ML00004885,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](/N=C\CCCCCCCCCOc3ccc([N+](=O)[O-])cc3OC)[C@H]2O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004885_numbered.png,2026-03-19 06:55:48.064315
2781,ML00003000,,,CC(=O)OC[C@]12[C@H](OC(=O)c3ccccc3)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2782,ML00009555,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@](C)(OC)[C@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009555_numbered.png,2026-03-19 06:55:48.136103
2783,ML00007942,,,C[C@H]1CCCC(=O)CCCC=Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007942_numbered.png,2026-03-19 06:55:48.161036
2784,ML00002145,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CNC(=O)NCc3ccc4nccnc4c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002145_numbered.png,2026-03-19 06:55:48.219172
2785,ML00002153,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cccc3ncccc23)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002153_numbered.png,2026-03-19 06:55:48.277027
2786,ML00007738,,,C[C@@H]1C[C@H]2O[C@@H]2CC/C=C\C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007738_numbered.png,2026-03-19 06:55:48.302214
2787,ML00008048,,,C[C@H]1CCC/C=C/[C@H](O)[C@H]2O[C@H]2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 9, 12]",ring_size_14/standard/numbered/ML00008048_numbered.png,2026-03-19 06:55:48.330558
2788,ML00001828,CHEMBL3936686,,CO[C@H]1/C=C/C=C\C(=O)CCC(=O)O[C@@H](C)CCC1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 12]",ring_size_14/standard/numbered/ML00001828_numbered.png,2026-03-19 06:55:48.358676
2789,ML00003114,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(-c4nccs4)nc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00003114_numbered.png,2026-03-19 06:55:48.422310
2790,ML00006610,,,CC[C@H](C)[C@@]1(O)CC(=O)O[C@H](C)[C@@](O)(C(C)C)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2791,ML00002776,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2N(NCCCc3ccnc4ccccc34)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002776_numbered.png,2026-03-19 06:55:48.487051
2792,ML00004327,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccc3[N+](=O)[O-])[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004327_numbered.png,2026-03-19 06:55:48.552838
2793,ML00007814,,,C[C@H]1C[C@H]2O[C@@H]2/C=C\C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007814_numbered.png,2026-03-19 06:55:48.579238
2794,ML00004576,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)(CN(C)Cc3ccc(-c4cn(CCCCCC(=O)NO)nn4)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(OC)CC(C)C(=O)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004576_numbered.png,2026-03-19 06:55:48.646535
2795,ML00011017,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2OC(=O)N3C)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2OC(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00011017_numbered.png,2026-03-19 06:55:48.704499
2796,ML00003222,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2ccc3ncccc3c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003222_numbered.png,2026-03-19 06:55:48.764665
2797,ML00004414,,,CCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](OP(=O)(Oc4ccccc4)Oc4ccccc4)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@](C)(O)[C@H](OC(=O)CC)[C@@H](C)C(=O)[C@H](C)C[C@]2(C)O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004414_numbered.png,2026-03-19 06:55:48.838026
2798,ML00008758,,,CO[C@H]1/C=C\[C@@](C)(O)/C=C\C(=O)O[C@H](C)[C@@H](C)CC/C=C\1C,standard_macrolactone,14.0,,,success,,6.0,"[3, 4, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00008758_numbered.png,2026-03-19 06:55:48.876983
2799,ML00003522,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](C(C)O)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003522_numbered.png,2026-03-19 06:55:48.941909
2800,ML00004667,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc(-c5cnc(N)nc5)c4)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004667_numbered.png,2026-03-19 06:55:49.000987
2801,ML00007989,,,C[C@@H]1C[C@@H](O)CCCC/C=C\CCCC(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 5]",ring_size_14/standard/numbered/ML00007989_numbered.png,2026-03-19 06:55:49.025753
2802,ML00009609,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3ccccn3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00009609_numbered.png,2026-03-19 06:55:49.078213
2803,ML00005694,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ccccc3)nc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2CC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005694_numbered.png,2026-03-19 06:55:49.134884
2804,ML00008385,,,COc1cc(O)c2c(c1)[C@H](O)[C@@H](O)C[C@@H]1O[C@H]1C(=O)CCC[C@@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 11, 12]",ring_size_14/standard/numbered/ML00008385_numbered.png,2026-03-19 06:55:49.167159
2805,ML00002306,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=C\C=C\c3cccnc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002306_numbered.png,2026-03-19 06:55:49.224018
2806,ML00004793,,,CC(=O)OC[C@@]12[C@@H](OC(=O)c3ccccc3)[C@H](OC(C)=O)[C@@H]3OC(=O)[C@@H](C)[C@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@@]1([C@H](OC(=O)c1ccccc1)[C@H]4[C@@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2807,ML00006228,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc5cnccc54)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006228_numbered.png,2026-03-19 06:55:49.291102
2808,ML00005695,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ccccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2CC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005695_numbered.png,2026-03-19 06:55:49.348966
2809,ML00006117,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC/C=C/c2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2c(C)cc(C)cc2C)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006117_numbered.png,2026-03-19 06:55:49.408237
2810,ML00002883,,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002883_numbered.png,2026-03-19 06:55:49.466091
2811,ML00010767,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010767_numbered.png,2026-03-19 06:55:49.529044
2812,ML00007062,,,CC(C)[C@@]1(O)CC(=O)O[C@H](C)[C@@](O)(C(C)C)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2813,ML00004705,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004705_numbered.png,2026-03-19 06:55:49.594674
2814,ML00007797,,,O=C1OCCCCCCCCCCc2cc(O)cc(O)c21,standard_macrolactone,14.0,,,success,,0.0,[],ring_size_14/standard/numbered/ML00007797_numbered.png,2026-03-19 06:55:49.613362
2815,ML00010478,,,O=C1CCCC/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](c2ccccc2)CO1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2816,ML00005946,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCCCc2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2Cl)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005946_numbered.png,2026-03-19 06:55:49.677081
2817,ML00006270,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc5c(N)ncnc54)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006270_numbered.png,2026-03-19 06:55:49.735699
2818,ML00008340,,,COc1cc(O)c2c(c1)C=CCC(O)C(O)C(O)C=CCC(C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008340_numbered.png,2026-03-19 06:55:49.766629
2819,ML00005916,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2ccc(-c3cccs3)cc2)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005916_numbered.png,2026-03-19 06:55:49.820776
2820,ML00004314,,,C#CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3cccc(F)c3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004314_numbered.png,2026-03-19 06:55:49.886126
2821,ML00002018,CHEMBL3680939,,COc1ccc2c(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)O)C[C@H]5/C=C\CCCCOC(=O)N4C3)cc(-c3ccccc3)nc2c1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2822,ML00003093,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](N2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003093_numbered.png,2026-03-19 06:55:49.958271
2823,ML00001373,CHEMBL360362,,CC(C)C[C@H](NC(=O)[C@@H]1CC(=O)NCCCCOC(=O)N[C@@H](C(C)C)C(=O)N1)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2824,ML00008784,,,CO[C@H]1/C=C\[C@@](C)(O)CCC(=O)O[C@H](C)[C@@H](C)[C@H](O)C/C=C\1C,standard_macrolactone,14.0,,,success,,7.0,"[3, 4, 5, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00008784_numbered.png,2026-03-19 06:55:50.005892
2825,ML00000768,CHEMBL584550,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(N)=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000768_numbered.png,2026-03-19 06:55:50.072308
2826,ML00010773,,,CC[C@H]1OC(=O)[C@H](C)C[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00010773_numbered.png,2026-03-19 06:55:50.133954
2827,ML00001057,CHEMBL1078776,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\CCOC2=O,standard_macrolactone,14.0,,,success,,3.0,"[7, 8, 9]",ring_size_14/standard/numbered/ML00001057_numbered.png,2026-03-19 06:55:50.162786
2828,ML00001601,CHEMBL1269452,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCc2c[nH]cn2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001601_numbered.png,2026-03-19 06:55:50.228072
2829,ML00001439,CHEMBL583098,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001439_numbered.png,2026-03-19 06:55:50.289998
2830,ML00006767,,,C[C@@H]1C/C=C/CC/C=C/C(=N/OCC(=O)N2CCCCC2)Cc2cc(OP(=O)(O)O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00006767_numbered.png,2026-03-19 06:55:50.316436
2831,ML00006044,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NCCC(C)CCCC(C)(C)OC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006044_numbered.png,2026-03-19 06:55:50.379633
2832,ML00004310,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NC/C=C/c3ccc([N+](=O)[O-])cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004310_numbered.png,2026-03-19 06:55:50.432704
2833,ML00009732,,,CC(=O)O[C@@H]1[C@H](O)[C@]2(OC(C)=O)[C@H](O)[C@H](Oc3ccncc3)[C@H]3OC(=O)[C@@H](C)[C@@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@]2([C@H](OC(C)=O)[C@H]14)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2834,ML00003083,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C(=O)CNCCN(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003083_numbered.png,2026-03-19 06:55:50.506896
2835,ML00005924,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2C(NC(=O)CCc3cnc4ccc(OC)cc4c3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005924_numbered.png,2026-03-19 06:55:50.565378
2836,ML00008375,,,COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OCCCC/C(S)=N/1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2837,ML00007957,,,CC1CCCCCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007957_numbered.png,2026-03-19 06:55:50.597073
2838,ML00010215,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@@H](C)C(=O)CC[C@]1(C)O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010215_numbered.png,2026-03-19 06:55:50.650318
2839,ML00003573,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3ccccc3O)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003573_numbered.png,2026-03-19 06:55:50.709362
2840,ML00003879,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCc2ccc(C)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003879_numbered.png,2026-03-19 06:55:50.779211
2841,ML00004526,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCCCNc3ccc4c(=O)c(C(=O)O)cn(CC)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004526_numbered.png,2026-03-19 06:55:50.850643
2842,ML00003100,,,CCCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003100_numbered.png,2026-03-19 06:55:50.920619
2843,ML00008134,,,CSCC[C@@H]1NC(=O)C/C=C\[C@@H](C)COC(=O)[C@@H](C)COC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2844,ML00002152,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCCCc2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002152_numbered.png,2026-03-19 06:55:50.985009
2845,ML00005501,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OCCNCCCOCCCNCc2ccc(Cl)c(Cl)c2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005501_numbered.png,2026-03-19 06:55:51.048493
2846,ML00004740,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNC)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004740_numbered.png,2026-03-19 06:55:51.120774
2847,ML00001043,CHEMBL3334712,,COc1cc(O)cc2c1C(=O)O[C@@H](C)CCCCC/C=C/C(=O)C2,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00001043_numbered.png,2026-03-19 06:55:51.146741
2848,ML00006560,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006560_numbered.png,2026-03-19 06:55:51.211217
2849,ML00007083,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@@]2(O)CO[C@@](OC)(C[C@@H](C)C/C(C)=C\[C@@]1(C)O)C2,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 4, 6, 8, 10, 12, 13, 14]",ring_size_14/standard/numbered/ML00007083_numbered.png,2026-03-19 06:55:51.259300
2850,ML00002656,,,CCC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002656_numbered.png,2026-03-19 06:55:51.322084
2851,ML00009748,,,CCCNC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009748_numbered.png,2026-03-19 06:55:51.385591
2852,ML00003116,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(-c4ncccn4)s3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00003116_numbered.png,2026-03-19 06:55:51.445086
2853,ML00001376,CHEMBL3577613,,C#CCO[C@@H]1[C@@H](C)[C@H](OC(=O)NCCCCNC(=N)NC(=O)NC)[C@@H](C)C(=O)O[C@H](CC)C(C)(C)[C@@H]2OC(C)(C)O[C@H]([C@@H]2C)[C@H](C)C[C@@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001376_numbered.png,2026-03-19 06:55:51.500813
2854,ML00003647,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1C(C)C(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2855,ML00003716,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C2=N[C@H](C)[C@@H](O2)[C@]1(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2856,ML00006772,,,C[C@@H]1C/C=C/CC/C=C/C(=N/OCC(=O)N2CCCCC2)Cc2cc(OP(=O)(O)O)cc(OP(=O)(O)O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00006772_numbered.png,2026-03-19 06:55:51.543052
2857,ML00000648,CHEMBL3827195,,CCCOc1cc(O)c2c(c1)/C=C/CCC[C@@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00000648_numbered.png,2026-03-19 06:55:51.567534
2858,ML00001677,CHEMBL1097786,,C[C@@H]1OC(=O)c2c(O)cc(OCCCS(C)(=O)=O)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001677_numbered.png,2026-03-19 06:55:51.601431
2859,ML00003090,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@@H]2N[C@@H](COCCOC)O[C@@H]([C@H]2C)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003090_numbered.png,2026-03-19 06:55:51.659262
2860,ML00003588,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2cncnc2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003588_numbered.png,2026-03-19 06:55:51.717152
2861,ML00008326,,,COc1cc(O)c2c(c1)/C=C\C[C@H](O)[C@H](O)[C@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008326_numbered.png,2026-03-19 06:55:51.748231
2862,ML00006057,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006057_numbered.png,2026-03-19 06:55:51.811864
2863,ML00001492,CHEMBL264043,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C3CCCC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001492_numbered.png,2026-03-19 06:55:51.872412
2864,ML00008733,,,COc1cc(O)c2c(c1Cl)C(=O)OCCCCC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2865,ML00005861,,,CC[C@H]1OC(=O)C(C)(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00005861_numbered.png,2026-03-19 06:55:51.939279
2866,ML00001215,CHEMBL1774288,,C=CCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001215_numbered.png,2026-03-19 06:55:52.004032
2867,ML00006140,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OCCNCCCOCCCNCc2cn(C)c3ccc(F)cc23)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006140_numbered.png,2026-03-19 06:55:52.067513
2868,ML00003496,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2OC(=O)N3C)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2OC(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003496_numbered.png,2026-03-19 06:55:52.126848
2869,ML00006048,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC(C)=O)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O[C@H]2C[C@@H](N(C)C)[C@@H](O)[C@H](C)O2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006048_numbered.png,2026-03-19 06:55:52.192924
2870,ML00001081,CHEMBL3828524,,CCOc1cc(O)c2c(c1)/C=C/CCC[C@@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00001081_numbered.png,2026-03-19 06:55:52.217199
2871,ML00009450,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@H](OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009450_numbered.png,2026-03-19 06:55:52.280451
2872,ML00008682,,,COc1cc(O)c2c(c1Br)C(=O)OCC(=O)N(C)CC(=S)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2873,ML00010960,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)[C@H](OC(=O)O2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010960_numbered.png,2026-03-19 06:55:52.335981
2874,ML00001742,CHEMBL557443,,COc1cc(OC)c2c(c1Cl)CC(=O)C/C=C/[C@@H](Sc1ccccc1)[C@H]1O[C@@H]1C[C@@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 11]",ring_size_14/standard/numbered/ML00001742_numbered.png,2026-03-19 06:55:52.366163
2875,ML00003625,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)C(=N)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003625_numbered.png,2026-03-19 06:55:52.430523
2876,ML00008371,,,COc1cc(O)cc2c1C(=O)OC(C)CCCC(=O)CCCCC2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008371_numbered.png,2026-03-19 06:55:52.455744
2877,ML00002874,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4cccc5ccccc45)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002874_numbered.png,2026-03-19 06:55:52.511546
2878,ML00003653,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2879,ML00002610,,,CCCN1CO[C@@H]2[C@@H](C)[C@@H]1[C@H](C)C[C@@](C)(O)[C@H](OC1OC(C)CC(N(C)C)C1O)[C@@H](C)[C@H](OC1CC(C)(OC)C(O)C(C)O1)[C@@H](C)C(=O)O[C@H](CC)[C@@]2(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002610_numbered.png,2026-03-19 06:55:52.577072
2880,ML00002175,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=C\C#Cc3ccc(N)nc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002175_numbered.png,2026-03-19 06:55:52.633634
2881,ML00007432,,,CC1CCCC(NCCc2ccccc2)CCCC=Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007432_numbered.png,2026-03-19 06:55:52.659582
2882,ML00007131,,,COc1cc(O)c2c(c1Br)C(=O)OCCN(C(=O)C1CC1)CC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2883,ML00004388,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]3OC(=O)c3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004388_numbered.png,2026-03-19 06:55:52.729206
2884,ML00010731,,,CCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)C[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00010731_numbered.png,2026-03-19 06:55:52.789105
2885,ML00002346,,,C=C[C@]12OC(=O)N(CCCCn3cnc4c(C)ncnc43)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002346_numbered.png,2026-03-19 06:55:52.846894
2886,ML00004354,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3cccc(Cl)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004354_numbered.png,2026-03-19 06:55:52.903658
2887,ML00002964,,,CCCCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002964_numbered.png,2026-03-19 06:55:52.968678
2888,ML00009543,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3ccncc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00009543_numbered.png,2026-03-19 06:55:53.022627
2889,ML00002865,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002865_numbered.png,2026-03-19 06:55:53.077805
2890,ML00008334,,,COc1cc(O)c2c(c1)[C@H]1O[C@@H]1CC[C@H](O)[C@@H](O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00008334_numbered.png,2026-03-19 06:55:53.106857
2891,ML00009662,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](O)[C@@H]3OC(=O)[C@@H](C)[C@H](C)c4ccncc4C(=O)OC[C@]4(C)O[C@@]1([C@@H](OC(C)=O)[C@H]4[C@@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2892,ML00006925,,,CC[C@@]1(O)C(=O)OCC2=CCN3CC[C@@H](OC(=O)[C@@](O)(C(C)C)[C@@H](O)C(=O)O[C@@H]1C)[C@@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2893,ML00007967,,,C[C@H]1C/C=C\[C@@H](O)[C@@H](O)CC/C=C\c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00007967_numbered.png,2026-03-19 06:55:53.148532
2894,ML00007387,,,CO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@]3(CO3)C[C@H](C)[C@H](O)[C@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00007387_numbered.png,2026-03-19 06:55:53.199979
2895,ML00003559,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3cc(O)ccc3O)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003559_numbered.png,2026-03-19 06:55:53.253366
2896,ML00007395,,,COc1cccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)c1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007395_numbered.png,2026-03-19 06:55:53.279079
2897,ML00003515,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCC(=O)NCc2ccc(F)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003515_numbered.png,2026-03-19 06:55:53.342359
2898,ML00001406,CHEMBL1256540,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3COC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001406_numbered.png,2026-03-19 06:55:53.407511
2899,ML00006474,,,CCCCNC(=O)CCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006474_numbered.png,2026-03-19 06:55:53.492202
2900,ML00009017,,,CO[C@@H]1C[C@@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@]3(CO3)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@@H](N(C)C)[C@H]3O)[C@H]2C)O[C@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009017_numbered.png,2026-03-19 06:55:53.547883
2901,ML00009565,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCCN2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009565_numbered.png,2026-03-19 06:55:53.611224
2902,ML00002500,,,CC(=O)OC[C@]12[C@H](O)[C@H](OC(=O)c3ccc(=O)n(C)c3)[C@H]3OC(=O)[C@@H](C)[C@@H](C)c4ncccc4C(=O)OC[C@@]4(C)O[C@]1([C@H](OC(C)=O)[C@@H]4[C@@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2903,ML00001768,CHEMBL560066,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCc2ccccc2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00001768_numbered.png,2026-03-19 06:55:53.649167
2904,ML00001573,CHEMBL1269441,,CCNC(=O)NCCO[C@H]1[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001573_numbered.png,2026-03-19 06:55:53.714629
2905,ML00006172,,,CNC1CC#CC(C(=O)O)C(=O)OCC2OC(OCC1N)C(OOc1cc3c(cc1Cc1cc(O)cc(CC4CCCCC4)c1)OCC1c4cc5c(c(CC(C)C)c4OC31)OCO5)C(O)C2O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2906,ML00008742,,,CCCCC[C@H]1CC/C=C\CCCCCCCC(=O)O1,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008742_numbered.png,2026-03-19 06:55:53.745222
2907,ML00002603,,,CCC1OC(=O)C(C)[C@@H](O[C@H]2C[C@@](C)(OC)C(O)C(C)O2)C(C)[C@@H](O[C@@H]2OC(C)CC(N(C)C)C2O)[C@](C)(O)CC(C)/C(=N\OCOCCOC)[C@H](C)C(O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002603_numbered.png,2026-03-19 06:55:53.818543
2908,ML00004162,,,CCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004162_numbered.png,2026-03-19 06:55:53.890283
2909,ML00003955,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2910,ML00010485,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2911,ML00008899,,,C[C@H]1C[C@@]2(CO2)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C)OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@H](O)[C@@H](O)[C@@H](C)O2)[C@H](C)[C@H]1O[C@H]1O[C@H](C)C[C@H](N(C)C)[C@@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00008899_numbered.png,2026-03-19 06:55:53.962407
2912,ML00010812,,,COc1ccc(C2CC(=O)Oc3cc4c(c(OC)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)c(OC)c1OC,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010812_numbered.png,2026-03-19 06:55:53.989461
2913,ML00005966,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(O)C(O)[C@H](C)O2)[C@H](C)[C@@H](OC2OC(C)C[C@H](N(C)C)C2O)[C@](C)(OC2CC(N(C)C)C(O)C(C)O2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005966_numbered.png,2026-03-19 06:55:54.057499
2914,ML00003254,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3ccc(C(F)(F)F)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003254_numbered.png,2026-03-19 06:55:54.113244
2915,ML00004228,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3cccc(N)n3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004228_numbered.png,2026-03-19 06:55:54.172717
2916,ML00002116,CHEMBL300794,,O=C(NC(Cc1ccccc1)C(O)CN1CCCCCCCCCCCOC1=O)O[C@H]1CO[C@H]2OCC[C@@H]12,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2917,ML00002471,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCCNCc2ccnc3ccccc23)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002471_numbered.png,2026-03-19 06:55:54.247117
2918,ML00004171,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=N/O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004171_numbered.png,2026-03-19 06:55:54.313963
2919,ML00010199,,,Cc1c(C(=O)COc2cc(O)c3c(c2)C=CCCCC(=O)CCCC(C)OC3=O)c2ccccc2n1C,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010199_numbered.png,2026-03-19 06:55:54.340113
2920,ML00003652,,,CC(=O)OC[C@]12[C@@H](OC(C)=O)[C@@H](OC(C)=O)C3[C@@H](OC(C)=O)C14O[C@]3(C)COC(=O)c1cccnc1[C@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2921,ML00004161,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(=O)NC)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004161_numbered.png,2026-03-19 06:55:54.412108
2922,ML00005631,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCN(C)C)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005631_numbered.png,2026-03-19 06:55:54.470709
2923,ML00008731,,,COc1cc(O)c2c(c1C)C(=O)OCC(=S)NCC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2924,ML00002344,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3nnnc3-c3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002344_numbered.png,2026-03-19 06:55:54.533906
2925,ML00006139,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006139_numbered.png,2026-03-19 06:55:54.598991
2926,ML00007922,,,C[C@H]1CCCC(=O)CCC/C=C/c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007922_numbered.png,2026-03-19 06:55:54.624007
2927,ML00006354,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006354_numbered.png,2026-03-19 06:55:54.683618
2928,ML00001497,CHEMBL567808,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCc2cccc(C(=O)NC)c2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001497_numbered.png,2026-03-19 06:55:54.749921
2929,ML00004244,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCn3nnc4ccccc43)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004244_numbered.png,2026-03-19 06:55:54.802919
2930,ML00007980,,,C[C@@H]1C[C@@H](O)[C@H](O)CCC(=O)O[C@H](C)C/C=C\C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2931,ML00006247,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O[C@H]3C[C@@H](N(C)C)[C@@H](O)[C@H](C)O3)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC(C)=O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006247_numbered.png,2026-03-19 06:55:54.875289
2932,ML00001783,CHEMBL3974111,,C[C@@H]1OC(=O)c2c(O)cc(NCCN3CCOCC3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001783_numbered.png,2026-03-19 06:55:54.909173
2933,ML00005687,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2ccc(-c3ccccn3)cc2)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005687_numbered.png,2026-03-19 06:55:54.962457
2934,ML00001240,CHEMBL1256543,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCOC)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001240_numbered.png,2026-03-19 06:55:55.026319
2935,ML00002467,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=N\OCc3ccccc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002467_numbered.png,2026-03-19 06:55:55.083684
2936,ML00009404,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)c2ccc([N+](=O)[O-])cc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)C2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009404_numbered.png,2026-03-19 06:55:55.148758
2937,ML00007747,,,COc1cc(O)c2c(c1Br)C(=O)OCCNCC(=S)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2938,ML00007587,,,CC[C@H](/C=C(/C)[C@@H]1C[C@@H](OC)C[C@H](O)C(C)(C)[C@@]2(O)O[C@@H](C[C@@H](O)[C@H](O)C(=O)O1)C[C@@H](OC)[C@H]2O)CO,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2939,ML00003845,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(NCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003845_numbered.png,2026-03-19 06:55:55.226661
2940,ML00009507,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3cccs3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00009507_numbered.png,2026-03-19 06:55:55.282012
2941,ML00007448,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3cccc(C(F)(F)F)c3)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007448_numbered.png,2026-03-19 06:55:55.310138
2942,ML00006208,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=C/c2cccc3ccccc23)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006208_numbered.png,2026-03-19 06:55:55.376555
2943,ML00000245,CHEMBL1384853,,COc1cc(OCC(=O)NC(C)C)cc2c1C(=O)O[C@@H](C)CCCC(=O)CCCCC2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00000245_numbered.png,2026-03-19 06:55:55.402279
2944,ML00010186,,,CC(C)Oc1ccccc1C1CC(=O)Oc2cc3c(c(O)c21)C(=O)OC(C)CCCC(=O)CCCC=C3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010186_numbered.png,2026-03-19 06:55:55.426620
2945,ML00003025,,,CC(=O)OCC12C(OC(C)=O)C(OC(=O)c3ccccc3)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)OC(C(OC(C)=O)C2OC(C)=O)C4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2946,ML00007700,,,C[C@@H]1C/C=C\[C@@H](O)C/C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 11]",ring_size_14/standard/numbered/ML00007700_numbered.png,2026-03-19 06:55:55.461410
2947,ML00002365,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc4nc(N)sc4c3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002365_numbered.png,2026-03-19 06:55:55.517311
2948,ML00010758,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\O)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010758_numbered.png,2026-03-19 06:55:55.574309
2949,ML00001316,CHEMBL1512198,,CCC1OC(=O)C(C)C(OC2C[C@@](C)(OC)C(O)C(C)O2)C(C)C(O[C@@H]2OC(C)CC(N(C)C)C2O)[C@](C)(O)CC(C)C(=NOCOCCOC)C(C)C(O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001316_numbered.png,2026-03-19 06:55:55.638276
2950,ML00009431,,,O=C1CCC[C@H](CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2)CO1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2951,ML00006129,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2cnc(C3CC3)nc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006129_numbered.png,2026-03-19 06:55:55.705964
2952,ML00003171,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NNCCc2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003171_numbered.png,2026-03-19 06:55:55.763894
2953,ML00006646,,,C[C@H](O)[C@H](C)[C@@H]1OC(=O)[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@H](C)C[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006646_numbered.png,2026-03-19 06:55:55.818280
2954,ML00006160,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(C)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006160_numbered.png,2026-03-19 06:55:55.886980
2955,ML00003657,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2956,ML00009774,,,CC(=O)OC[C@]12[C@@H](OC(C)=O)C(=O)[C@H]3[C@@H](OC(C)=O)[C@]14O[C@]3(C)COC(=O)c1cccnc1[C@H](C)[C@@H](C)C(=O)O[C@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2957,ML00010200,,,COc1cc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc2c1OCCO2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010200_numbered.png,2026-03-19 06:55:55.930465
2958,ML00009417,,,CC(C)(N)CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)CCC[C@H](CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2959,ML00003618,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](N)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003618_numbered.png,2026-03-19 06:55:55.998888
2960,ML00002790,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NN(C)CCc2ccc(-c3ncco3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002790_numbered.png,2026-03-19 06:55:56.057350
2961,ML00001917,CHEMBL3577614,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCc2cn(CCNC(=N)NC(=O)NC)nn2)[C@H](C)[C@@H](O)[C@](C)(O)C[C@@H](C)[C@@H]2OC(C)(C)O[C@H]([C@H]2C)C1(C)C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001917_numbered.png,2026-03-19 06:55:56.114696
2962,ML00000311,CHEMBL584549,3 9-DIHYDRO-N-DESMETHYL-N-ISOPROPYLERYTHROMYCIN A,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000311_numbered.png,2026-03-19 06:55:56.180294
2963,ML00004340,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccc(F)c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CC3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004340_numbered.png,2026-03-19 06:55:56.245365
2964,ML00006085,,,CC(=O)O[C@H]1[C@@H](OC(=O)C(C)C)[C@]2(COC(=O)C(C)C)[C@@H](OC(=O)C(C)C)[C@@H](OC(=O)c3ccc(=O)n(C)c3)[C@@H]3OC(=O)[C@@H](C)[C@H](C)c4ccncc4C(=O)OC[C@]4(C)O[C@@]2([C@H](OC(C)=O)[C@@H]14)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2965,ML00005940,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)N(CC)[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00005940_numbered.png,2026-03-19 06:55:56.313239
2966,ML00006051,,,CO[C@H]1[C@@H](OC)[C@H](O)[C@@H](C)O[C@H]1OC[C@H](C)[C@@H]1OC(=O)[C@@H](C)[C@H](O[C@@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)CC(=O)[C@H]2O)[C@H](C)C[C@@](C)(O)C(=O)[C@H](C)[C@H](OC(=O)[C@H](O)C(C)C)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006051_numbered.png,2026-03-19 06:55:56.377299
2967,ML00004000,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@]4(C)[C@@H](O)[C@H](O)[C@@H]2OC(C)=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2968,ML00008803,,,CC[C@H]1OC(=O)CCCCCCC/C=C\[C@H]2[C@H](O)[C@@H](Cl)C[C@H]12,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008803_numbered.png,2026-03-19 06:55:56.407704
2969,ML00003651,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2970,ML00008937,,,COC(=O)c1cc(C(=O)OC)cc(-c2ccc(C3CC(=O)Oc4cc5c(c(O)c43)C(=O)OC(C)CCCC(=O)CCCC=C5)o2)c1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008937_numbered.png,2026-03-19 06:55:56.440554
2971,ML00002481,,,C/C=C(/C)C(=O)O[C@H]1[C@@H](OC(C)=O)[C@@H]2OC(=O)[C@@H](C)[C@H](C)c3ncccc3C(=O)OC[C@]3(C)O[C@@]4([C@H](OC(C)=O)[C@H]3[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@]14COC(C)=O)[C@@]2(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2972,ML00003300,,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NCCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003300_numbered.png,2026-03-19 06:55:56.506004
2973,ML00004118,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3nccnc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004118_numbered.png,2026-03-19 06:55:56.563044
2974,ML00004264,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2Cl)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004264_numbered.png,2026-03-19 06:55:56.627201
2975,ML00010189,,,CC(C)Oc1ccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010189_numbered.png,2026-03-19 06:55:56.652588
2976,ML00005282,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNCCc2ccccc2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005282_numbered.png,2026-03-19 06:55:56.718753
2977,ML00003229,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2cnc3ccccc3c2)C[C@@H](C)/C(=N\OC)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00003229_numbered.png,2026-03-19 06:55:56.779356
2978,ML00003224,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2cnc3ccccc3c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003224_numbered.png,2026-03-19 06:55:56.836313
2979,ML00009855,,,CC[C@H]1OC(=O)[C@H](C)C2(O)O[C@@](C)(C[C@@H](C)CN(C(=O)Nc3ccc(Cl)cc3Cl)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2980,ML00005712,,,CNC1CC#CC(C(=O)O)C(=O)OCC2OC(OCC1N)C(OOc1cc3c(cc1Cc1cccc(O)c1)OCC1c4cc5c(c(CC(C)C)c4OC31)OCO5)C(O)C2OCCCO,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2981,ML00001574,CHEMBL1269445,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCNC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001574_numbered.png,2026-03-19 06:55:56.914467
2982,ML00008001,,,C[C@H]1COC(=O)[C@H](C)NC(=O)[C@@H](C)COC(=O)[C@H](C)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2983,ML00007719,,,COc1cc(O)c2c(c1Br)C(=O)OCC(=S)NCC(=S)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2984,ML00003221,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2cccc3cnccc23)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003221_numbered.png,2026-03-19 06:55:56.984100
2985,ML00003564,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cncnc2)[C@H](C)[C@@H]2OC(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003564_numbered.png,2026-03-19 06:55:57.041212
2986,ML00005866,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CC(C)(C)C[C@@H]2c2cccc(Cl)c2Cl)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005866_numbered.png,2026-03-19 06:55:57.100770
2987,ML00002357,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(C(N)=O)cc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002357_numbered.png,2026-03-19 06:55:57.157135
2988,ML00003070,,,CO[C@H]1[C@@H](OC)[C@H](O)[C@@H](C)O[C@H]1OC[C@H](C)[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@](C)(O)[C@@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O)[C@H](C)C[C@](C)(O)C(=O)[C@H](C)[C@H](OC(=O)[C@H](O)C(C)C)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003070_numbered.png,2026-03-19 06:55:57.218349
2989,ML00007118,,,COc1cc(O)c2c(c1)/C=C\C[C@@H]1OC(C)(C)O[C@@H]1[C@@H](O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007118_numbered.png,2026-03-19 06:55:57.244539
2990,ML00002429,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)/C(C)=C/[C@]1(C)OC(=O)NCCCSc1nc2ccccc2o1,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002429_numbered.png,2026-03-19 06:55:57.304188
2991,ML00007762,,,COc1cc(O)c2c(c1Br)C(=O)OCC(=O)NCC(=S)N[C@H](c1nc(CN)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2992,ML00003009,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2993,ML00007897,,,C[C@@H]1C[C@H](O)CCCCCC(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 5, 11]",ring_size_14/standard/numbered/ML00007897_numbered.png,2026-03-19 06:55:57.347236
2994,ML00010921,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2OC(=O)N3C)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2OC(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010921_numbered.png,2026-03-19 06:55:57.405168
2995,ML00009558,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009558_numbered.png,2026-03-19 06:55:57.471174
2996,ML00002075,CHEMBL1081555,,O=C(C[C@H]1C/C=C/CCCCC(=O)O[C@@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2997,ML00002207,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@@H](OC(=O)c3cccnc3)[C@H]3[C@H](OC(C)=O)[C@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2998,ML00000364,CHEMBL85010,,CCOCCNC(=O)CO/N=C1\C=C\C=C/[C@H]2O[C@@H]2C[C@@H](C)OC(=O)c2c(O)cc(O)c(Cl)c2C1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000364_numbered.png,2026-03-19 06:55:57.510421
2999,ML00006513,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3000,ML00002585,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NCCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002585_numbered.png,2026-03-19 06:55:57.581887
3001,ML00002240,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=C/c2ccc3cccnc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002240_numbered.png,2026-03-19 06:55:57.639691
3002,ML00005952,,,C=C[C@]12OC(=O)N(CCCCn3ccc4nc(C(C)=O)ccc43)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005952_numbered.png,2026-03-19 06:55:57.697951
3003,ML00003591,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)[C@H](OC(=O)O2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003591_numbered.png,2026-03-19 06:55:57.750293
3004,ML00005834,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCNC(=O)NCc3cnc4ccccc4c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005834_numbered.png,2026-03-19 06:55:57.806581
3005,ML00002602,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H](C)C(=NOCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002602_numbered.png,2026-03-19 06:55:57.872574
3006,ML00003993,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccco1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3007,ML00005521,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3008,ML00008374,,,COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OCCCCC(=O)N1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3009,ML00008359,,,COc1cc(O)c2c(c1)/C=C\C[C@H](O)[C@H](O)[C@H](O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008359_numbered.png,2026-03-19 06:55:57.930229
3010,ML00002518,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)C(=N)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(-c4nccs4)nc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002518_numbered.png,2026-03-19 06:55:57.989974
3011,ML00004255,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2Br)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004255_numbered.png,2026-03-19 06:55:58.055294
3012,ML00005993,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3cccnc3)[C@@H]3[C@@H](OC(=O)c4ccoc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3013,ML00006988,,,COc1cc(O)c2c(c1C)C(=O)OC[C@H](CO)CCC(=S)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3014,ML00002177,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(C(N)=O)cc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002177_numbered.png,2026-03-19 06:55:58.130731
3015,ML00006587,,,C/C1=C/CC[C@H](C)[C@@H](C)OC(=O)/C=C\[C@](C)(O)/C=C\[C@@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O,standard_macrolactone,14.0,,,success,,6.0,"[3, 4, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00006587_numbered.png,2026-03-19 06:55:58.170323
3016,ML00004636,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OCCNCC2CCC(CNCc3cccc(Oc4ccccc4)c3)CC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004636_numbered.png,2026-03-19 06:55:58.233614
3017,ML00008744,,,CC[C@@H]1OC(=O)CCCCCCC/C=C\[C@H]2[C@H]1C[C@@H]1O[C@@H]12,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008744_numbered.png,2026-03-19 06:55:58.256303
3018,ML00004270,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3cccc(N)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004270_numbered.png,2026-03-19 06:55:58.308288
3019,ML00002072,CHEMBL1099197,,COc1ccc(COc2cc(O)c3c(c2)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC3=O)cc1,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00002072_numbered.png,2026-03-19 06:55:58.342789
3020,ML00005984,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC2CCCN(CCCC3CCCCC3)C2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005984_numbered.png,2026-03-19 06:55:58.404882
3021,ML00006322,,,CC(=O)O[C@@H]1[C@H](OC(=O)C(C)C)[C@@H]2[C@@H](OC(C)=O)[C@@]34O[C@@]2(C)COC(=O)c2cnccc2[C@@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(=O)c2ccc(=O)n(C)c2)[C@H](OC(C)=O)[C@@]13COC(=O)C(C)C)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3022,ML00005526,,,CCCCCCCCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005526_numbered.png,2026-03-19 06:55:58.477373
3023,ML00003113,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=N\OCc3cc(-c4ccc(C#N)s4)no3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003113_numbered.png,2026-03-19 06:55:58.534194
3024,ML00009353,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](O)[C@@H]3[C@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3025,ML00001063,CHEMBL3891809,,C[C@H]1CCC[C@@H](O)/C=C/C=C\[C@@H](O)/C=C/C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 12]",ring_size_14/standard/numbered/ML00001063_numbered.png,2026-03-19 06:55:58.568917
3026,ML00000247,CHEMBL314705,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)N2CCCC2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000247_numbered.png,2026-03-19 06:55:58.594733
3027,ML00002464,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nc4ccc(OC)nc4[nH]3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002464_numbered.png,2026-03-19 06:55:58.650037
3028,ML00002248,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](O)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@@H]2NC(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002248_numbered.png,2026-03-19 06:55:58.706887
3029,ML00005964,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O[C@H]2C[C@@H](N(C)C)[C@@H](O)[C@H](C)O2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005964_numbered.png,2026-03-19 06:55:58.772595
3030,ML00000218,CHEMBL498908,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000218_numbered.png,2026-03-19 06:55:58.859997
3031,ML00010207,,,C[C@H]1C[C@@H](C)C(=O)/C=C\[C@](C)(O)[C@@H]([C@@H](C)O)OC(=O)[C@H](C)C(=O)[C@H](C)[C@H]1O[C@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010207_numbered.png,2026-03-19 06:55:58.916779
3032,ML00010271,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O)[C@](C)(O)C[C@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010271_numbered.png,2026-03-19 06:55:58.980940
3033,ML00003115,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CNC(=O)OCc3cccc4ncccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003115_numbered.png,2026-03-19 06:55:59.038900
3034,ML00007782,,,C/C1=C/CC[C@H](C)[C@@H](C)OC(=O)/C=C\[C@](C)(O)CC[C@@H]1O,standard_macrolactone,14.0,,,success,,6.0,"[3, 4, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00007782_numbered.png,2026-03-19 06:55:59.077000
3035,ML00000209,CHEMBL1214760,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000209_numbered.png,2026-03-19 06:55:59.130041
3036,ML00002816,,,CC[C@H]1OC(=O)/C(C)=C\[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00002816_numbered.png,2026-03-19 06:55:59.184506
3037,ML00003988,,,CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H]2[C@@H](OC(C)=O)[C@@]34O[C@@]2(C)COC(=O)c2cnccc2C(C)C(C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]13COC(=O)c1ccco1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3038,ML00006161,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3ccc(-c4cn(CC(=O)NO)nn4)cc3)C2O)C(C)(OC)CC(C)C(=O)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006161_numbered.png,2026-03-19 06:55:59.258239
3039,ML00007760,,,COc1cc(O)c2c(c1Br)C(=O)OCC(=O)NCC(=O)N[C@H](c1nc(CN)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3040,ML00009598,,,CC[C@H]1OC(=O)[C@H](C)[C@@]2(O)O[C@@](C)(C[C@@H](C)CN3/C(=N\Cc4ccccc4)O[C@H]([C@H]3C)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3041,ML00002521,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2ccc(-c3nnn(C)n3)s2)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002521_numbered.png,2026-03-19 06:55:59.330494
3042,ML00006912,,,C=C1/C=C(\CO)[C@H](CC)OC(=O)[C@H](C)C(=O)[C@@](O)(CO)C/C(C)=C/[C@@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00006912_numbered.png,2026-03-19 06:55:59.379744
3043,ML00008734,,,COc1cc(O)c2c(c1Cl)C(=O)OCCCCC(=S)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3044,ML00007975,,,C[C@@H]1C/C=C/CC/C=C/[C@H](O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007975_numbered.png,2026-03-19 06:55:59.410837
3045,ML00004304,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@H]2N(NC/C=C/c3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004304_numbered.png,2026-03-19 06:55:59.463647
3046,ML00000089,CHEMBL1668420,,COc1cc(O)c2c(c1)/C=C\CCCC(=O)/C=C/C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00000089_numbered.png,2026-03-19 06:55:59.488190
3047,ML00006226,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc5ncccc54)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006226_numbered.png,2026-03-19 06:55:59.546445
3048,ML00001276,CHEMBL3143008,,CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)CCC[C@H](CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3049,ML00009892,,,CCCCC[C@H]1C[C@@H]2CCC[C@@H](C[C@@H](OC)C[C@@H]3C[C@@H](OC(=O)/C=C\CCc4coc(/C=C\CNC(=O)OC)n4)C[C@H](CC(=O)O1)O3)O2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3050,ML00001571,CHEMBL1269440,,CCOC(=O)NCCO[C@H]1[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001571_numbered.png,2026-03-19 06:55:59.624713
3051,ML00007491,,,CCCCCCC[C@@H]1CC(=O)N[C@@H](CO)C(=O)O[C@H](CCCCCC)CC(=O)N[C@@H](CO)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3052,ML00004243,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCn3nc4ccccc4n3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004243_numbered.png,2026-03-19 06:55:59.683144
3053,ML00006077,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc5cncnc54)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006077_numbered.png,2026-03-19 06:55:59.741714
3054,ML00008794,,,CCCCC[C@H]1/C=C\C(=O)CCCCCCCCC(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 6]",ring_size_14/standard/numbered/ML00008794_numbered.png,2026-03-19 06:55:59.766737
3055,ML00010150,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(C1=Cc2ccccc2OC1)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010150_numbered.png,2026-03-19 06:55:59.791826
3056,ML00007440,,,CC1COC(=O)C(Cc2ccccc2)NC(=O)C(C)COC(=O)C(Cc2ccccc2)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3057,ML00001802,CHEMBL563902,,C[C@@H]1C[C@H]2OC(=O)O[C@H]2/C=C\C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00001802_numbered.png,2026-03-19 06:55:59.822005
3058,ML00005863,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)N(C)[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00005863_numbered.png,2026-03-19 06:55:59.886148
3059,ML00005957,,,C=C[C@]12OC(=O)N(CCCCn3cc(-c4ccc(Cl)nc4)nc3C)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005957_numbered.png,2026-03-19 06:55:59.943134
3060,ML00006101,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC2CCCN(c3ccc(-c4ccc(C)cc4)cc3)C2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006101_numbered.png,2026-03-19 06:56:00.008128
3061,ML00007958,,,CC1CCCC(=O)CCC/C=C/c2cc(OS(=O)(=O)O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007958_numbered.png,2026-03-19 06:56:00.033997
3062,ML00007134,,,CCC1OC(=O)C(C)C(O)C(C)C(O)C(C)CC(C)C(=O)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00007134_numbered.png,2026-03-19 06:56:00.089356
3063,ML00006338,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1cccnc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3064,ML00009456,,,CC[C@@H]1OC(=O)[C@@H](C)[C@@H](O[C@H]2C[C@@H](OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@@H](C)[C@@H](O)[C@@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009456_numbered.png,2026-03-19 06:56:00.161812
3065,ML00006360,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2C(NC(=O)/C=C/CCc3cnc4ccc(OC)cc4c3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006360_numbered.png,2026-03-19 06:56:00.217823
3066,ML00005451,,,CCCCCCCCCCCCNNC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N/OCCCC3CCCCC3)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005451_numbered.png,2026-03-19 06:56:00.283933
3067,ML00009169,,,C=C1C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@H](CC)[C@@]2(C)OC(=O)N[C@H]12,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009169_numbered.png,2026-03-19 06:56:00.339676
3068,ML00004873,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc(-c5cccnc5)c4)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004873_numbered.png,2026-03-19 06:56:00.398587
3069,ML00001618,CHEMBL583097,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCCCCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001618_numbered.png,2026-03-19 06:56:00.463847
3070,ML00008406,,,C=C1/C=C(\C)[C@H](CC)OC(=O)[C@H](C)C(=O)[C@@](O)(CO)C/C(Cl)=C/[C@@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00008406_numbered.png,2026-03-19 06:56:00.511650
3071,ML00003243,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccco1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3072,ML00001380,CHEMBL1528078,,CC[C@@H]1OC(=O)[C@@H](C)[C@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@H](O[C@@H]2O[C@@H](C)C[C@@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@H](C)C(=O)[C@@H](C)[C@H](O)[C@@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001380_numbered.png,2026-03-19 06:56:00.586984
3073,ML00007717,,,COc1cc(O)c2c(c1Br)C(=O)OCC(=O)NCC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3074,ML00003290,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4ccncc4)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003290_numbered.png,2026-03-19 06:56:00.650464
3075,ML00002412,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(-n4cccn4)nc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002412_numbered.png,2026-03-19 06:56:00.707315
3076,ML00003997,,,CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H]2[C@@H](OC(C)=O)[C@@]34O[C@@]2(C)COC(=O)c2cnccc2C(C)C(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]13COC(=O)c1ccco1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3077,ML00008730,,,COc1cc(O)c2c(c1C)C(=O)OCC(=O)NCC(=S)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3078,ML00004369,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NN2CCCCC2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004369_numbered.png,2026-03-19 06:56:00.787696
3079,ML00004573,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004573_numbered.png,2026-03-19 06:56:00.854304
3080,ML00006488,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCC#Cc2ccc3[nH]ccc3c2)[C@H](C)[C@@H](O[C@@H]2OCC[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2Cl)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006488_numbered.png,2026-03-19 06:56:00.913131
3081,ML00001779,CHEMBL1094533,,C[C@@H]1OC(=O)c2c(O)cc(OCCN3CCOCC3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001779_numbered.png,2026-03-19 06:56:00.947618
3082,ML00009632,,,C=CC1O[C@@H](O[C@@H]2C(C)C(=O)O[C@H](C)[C@H](C)C(OC(C)=O)C(C)C(=O)[C@]3(CO3)C[C@H](C)[C@H](OC3OC(C)CC(N(C)C)[C@H]3O)[C@H]2C)C[C@@H]1OC,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009632_numbered.png,2026-03-19 06:56:01.002254
3083,ML00004175,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004175_numbered.png,2026-03-19 06:56:01.067568
3084,ML00001775,CHEMBL3900978,,C[C@@H]1OC(=O)c2c(O)cc(CCCn3ccnc3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001775_numbered.png,2026-03-19 06:56:01.101649
3085,ML00005400,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](COC(=O)c4ccccc4)[C@@H](OC(=O)c4ccccc4)[C@H](OC(C)=O)[C@H]3OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005400_numbered.png,2026-03-19 06:56:01.172484
3086,ML00004231,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)[C@H]2[C@H](C)[C@H]3N(C(=O)O[C@]13C)N2CCCc1ccccc1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004231_numbered.png,2026-03-19 06:56:01.223154
3087,ML00002560,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@@H](n2cccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002560_numbered.png,2026-03-19 06:56:01.288948
3088,ML00003616,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](N)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003616_numbered.png,2026-03-19 06:56:01.353516
3089,ML00003257,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2cccnc2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003257_numbered.png,2026-03-19 06:56:01.411277
3090,ML00007984,,,C[C@@H]1CCCCCC/C=C\CCC(=O)OC1,standard_macrolactone,14.0,,,success,,1.0,[4],ring_size_14/standard/numbered/ML00007984_numbered.png,2026-03-19 06:56:01.433308
3091,ML00002605,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002605_numbered.png,2026-03-19 06:56:01.496351
3092,ML00006563,,,CCCCCCCCC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006563_numbered.png,2026-03-19 06:56:01.559134
3093,ML00003963,,,CC(=O)OC[C@]12[C@H](OC(=O)c3ccccc3)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3094,ML00004227,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)/C=C/c2ccco2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004227_numbered.png,2026-03-19 06:56:01.638816
3095,ML00008443,,,C/C1=C/C(=O)O[C@@H](CC(O)[C@@H]2CSC(=O)N2)C[C@H](O)CC[C@H](C)/C=C\CC1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 8, 13]",ring_size_14/standard/numbered/ML00008443_numbered.png,2026-03-19 06:56:01.671434
3096,ML00002573,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](OC(=O)CC)[C@@H](C)C(=O)[C@]3(CO3)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]2C)C[C@@H]1OC,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002573_numbered.png,2026-03-19 06:56:01.726470
3097,ML00003576,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2ccc(Cl)cc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003576_numbered.png,2026-03-19 06:56:01.789969
3098,ML00003780,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2OC(=O)N3C)[C@](C)(OC)C[C@@H](C)C(=O)/C(C)=C/[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003780_numbered.png,2026-03-19 06:56:01.851921
3099,ML00005956,,,CC[C@H]1OC(=O)[C@H](C)C[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Oc4ccccc4)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00005956_numbered.png,2026-03-19 06:56:01.904401
3100,ML00011006,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3O[C@@](O)(C2)[C@H](C)C(=O)O[C@@H](/C=C/C=C\Br)C[C@@H](C)C/C=C\[C@H](O)[C@@H]3C)[C@H](OC)[C@@H]1OC,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3101,ML00002263,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#CCc2ccc(-c3csnn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002263_numbered.png,2026-03-19 06:56:01.970828
3102,ML00009521,,,CC[C@H]1OC(=O)[C@@H]2COC3(C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)O[C@H]2[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12]",ring_size_14/standard/numbered/ML00009521_numbered.png,2026-03-19 06:56:02.027255
3103,ML00005396,,,CCOC(=O)c1cn(CC)c2ccc(C#CCN3CCN(CCC(=O)O[C@H]4[C@H](C)O[C@@H](O[C@H]5[C@H](C)[C@@H](O[C@@H]6O[C@H](C)C[C@H](N(C)C)[C@H]6O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]5C)C[C@@]4(C)OC)CC3)cc2c1=O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005396_numbered.png,2026-03-19 06:56:02.094323
3104,ML00008010,,,C[C@H]1CCC/C=C\[C@H](O)[C@H]2O[C@H]2[C@H](O)/C=C\C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 9, 12]",ring_size_14/standard/numbered/ML00008010_numbered.png,2026-03-19 06:56:02.123744
3105,ML00007399,,,CC[C@H]1/C=C\[C@H]([C@@H](C)O)OC(=O)[C@@]2(C)C=CC(=O)NC3=C2C(=O)c2c(cc(C)c(O)c2C(=O)CC1)C3=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 6, 9, 12, 14]",ring_size_14/standard/numbered/ML00007399_numbered.png,2026-03-19 06:56:02.163585
3106,ML00004887,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3ccc(-c4cn(CCCCCC(=O)NO)nn4)cc3)C2O)C(C)(OC)CC(C)C(=O)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004887_numbered.png,2026-03-19 06:56:02.231212
3107,ML00004775,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CCc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004775_numbered.png,2026-03-19 06:56:02.291993
3108,ML00003008,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3109,ML00002967,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CNC(=O)NCc3ccc4ncccc4c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002967_numbered.png,2026-03-19 06:56:02.367007
3110,ML00009472,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCCCOC)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009472_numbered.png,2026-03-19 06:56:02.437702
3111,ML00000938,CHEMBL268489,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)C2CCOC2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000938_numbered.png,2026-03-19 06:56:02.512797
3112,ML00002973,,,CC(=O)C[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3113,ML00007311,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3ccccc3)cc(OCC3CO3)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007311_numbered.png,2026-03-19 06:56:02.557968
3114,ML00003523,,,CC[C@@]1(O)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,14.0,"[3, 3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003523_numbered.png,2026-03-19 06:56:02.628232
3115,ML00010813,,,COc1cccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)c1OC(C)C,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010813_numbered.png,2026-03-19 06:56:02.656084
3116,ML00002802,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(=O)CN)[C@H](C)C(OC/C(=C\C=C\c3ccccc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002802_numbered.png,2026-03-19 06:56:02.716024
3117,ML00003011,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]3[C@H](OC(C)=O)[C@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@H]([C@@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3118,ML00005959,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2ccc(C(=O)c3ccccc3)s2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005959_numbered.png,2026-03-19 06:56:02.787986
3119,ML00005502,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OCCNCCCOCCCNCc2cc(Cl)cc(Cl)c2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005502_numbered.png,2026-03-19 06:56:02.853242
3120,ML00000825,CHEMBL126153,,CC(C)CC1CCCC(=O)OC[C@H](NC(=O)C(Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC2CCCCC2)[C@@H](O)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3121,ML00006758,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3ccc([N+](=O)[O-])cc3)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00006758_numbered.png,2026-03-19 06:56:02.885189
3122,ML00008799,,,CCCCC[C@H]1/C=C\C=C/CCCCCCCC(=O)O1,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008799_numbered.png,2026-03-19 06:56:02.905928
3123,ML00006786,,,C/C=C1/[C@H]2OC=C(C(=O)OC)[C@H]1CC(=O)OC[C@H](c1ccc(O)c(O)c1)OC[C@H]1O[C@@H](O2)[C@H](O)[C@@H](O)[C@@H]1O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3124,ML00004218,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cncc(C(N)=O)c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00004218_numbered.png,2026-03-19 06:56:02.973121
3125,ML00002474,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCc3cccc(Cl)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002474_numbered.png,2026-03-19 06:56:03.029806
3126,ML00001880,CHEMBL1099228,ZEAENOL,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)[C@@H](O)/C=C/C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001880_numbered.png,2026-03-19 06:56:03.061609
3127,ML00006400,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006400_numbered.png,2026-03-19 06:56:03.126106
3128,ML00010713,,,CC[C@@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2CC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010713_numbered.png,2026-03-19 06:56:03.181432
3129,ML00003654,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(=O)[C@H](C)[C@@H](C)c4ncccc4C(=O)OC[C@@]4(C)O[C@]1([C@@H](OC(C)=O)[C@@H]4[C@@H](OC(C)=O)[C@H]2OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3130,ML00003829,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C3=CCCC3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003829_numbered.png,2026-03-19 06:56:03.253548
3131,ML00005731,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC/C(=N\Oc3ccc(-c4ccccc4)cc3)CCO[C@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]3NC(=O)O[C@]13C)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00005731_numbered.png,2026-03-19 06:56:03.303408
3132,ML00002194,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CNC(=O)OCc3ccc4nccnc4c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002194_numbered.png,2026-03-19 06:56:03.359271
3133,ML00001744,CHEMBL1095673,,C[C@@H]1OC(=O)c2c(O)cc(OCc3ccccc3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001744_numbered.png,2026-03-19 06:56:03.393438
3134,ML00006344,,,C=C[C@]12OC(=O)N(CCN(C)Cc3cccc(-c4cccnc4)c3)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006344_numbered.png,2026-03-19 06:56:03.449974
3135,ML00007812,,,C[C@@H]1C[C@@H]2O[C@H]2/C=C\C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007812_numbered.png,2026-03-19 06:56:03.475514
3136,ML00002963,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](NCCNCCNCc3nccs3)[C@@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002963_numbered.png,2026-03-19 06:56:03.537965
3137,ML00004828,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(-c5ccc(Cl)cc5)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004828_numbered.png,2026-03-19 06:56:03.605062
3138,ML00001648,CHEMBL1269450,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCc2ccncc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001648_numbered.png,2026-03-19 06:56:03.671831
3139,ML00010931,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3O[C@@](O)(C2)[C@@H](C)C(=O)O[C@@H](/C=C/C=C/Br)C[C@@H](C)/C=C\C[C@H](O)[C@@H]3C)[C@H](OC)[C@@H]1OC,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3140,ML00002613,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NCCCC#N)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002613_numbered.png,2026-03-19 06:56:03.742338
3141,ML00005839,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NN(C)CCc2ccc(-c3cnccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005839_numbered.png,2026-03-19 06:56:03.803192
3142,ML00006467,,,CCCCCCCCCCN[C@@H]1[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006467_numbered.png,2026-03-19 06:56:03.869875
3143,ML00010978,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3O[C@@](O)(C2)[C@@H](C)C(=O)O[C@@H](/C=C/C=C\Br)C[C@@H](C)C/C=C\[C@H](O)[C@@H]3C)[C@H](OC)[C@@H]1OC,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3144,ML00006924,,,CC[C@@]1(O)C(=O)OCC2=CCN3CC[C@@H](OC(=O)[C@@](O)(C(C)C)[C@H](O)C(=O)O[C@@H]1C)[C@@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3145,ML00000479,CHEMBL275467,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000479_numbered.png,2026-03-19 06:56:03.942209
3146,ML00007723,,,C[C@@H]1C[C@@H]2O[C@H]2/C=C\C=C/C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007723_numbered.png,2026-03-19 06:56:03.968002
3147,ML00003252,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](OC(=O)Nc3ccc(C(F)(F)F)cc3)[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\O)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003252_numbered.png,2026-03-19 06:56:04.027861
3148,ML00003293,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](CNCc2cccnc2)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003293_numbered.png,2026-03-19 06:56:04.088594
3149,ML00003088,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@@H]2NC(COCCOC)O[C@H]([C@H]2C)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003088_numbered.png,2026-03-19 06:56:04.146463
3150,ML00004353,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)c2ccc(Cl)cc2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004353_numbered.png,2026-03-19 06:56:04.209583
3151,ML00008022,,,C[C@H]1CCCCCCCCCCCC(=O)O1,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008022_numbered.png,2026-03-19 06:56:04.231448
3152,ML00003905,,,C=CCOC1[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cncnc2)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003905_numbered.png,2026-03-19 06:56:04.299336
3153,ML00004273,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CNC(=O)OCc2ccccc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)C2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004273_numbered.png,2026-03-19 06:56:04.363572
3154,ML00001603,CHEMBL1778053,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)N(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001603_numbered.png,2026-03-19 06:56:04.428070
3155,ML00008502,,,COc1cc(O)c2c(c1OC)/C=C\C[C@H](O)[C@H](O)C(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008502_numbered.png,2026-03-19 06:56:04.459332
3156,ML00003785,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003785_numbered.png,2026-03-19 06:56:04.522716
3157,ML00002448,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccc([N+](=O)[O-])cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002448_numbered.png,2026-03-19 06:56:04.588586
3158,ML00007745,,,C[C@@H]1C[C@H]2O[C@@H]2C[C@H](O)/C=C\C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 8, 11]",ring_size_14/standard/numbered/ML00007745_numbered.png,2026-03-19 06:56:04.617302
3159,ML00003210,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@@H](C)C(=O)O[C@@H]([C@@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3160,ML00005616,,,C=CCN1C(=O)N(CCCCn2cnc(-c3cccnc3)c2)[C@@H]2[C@@H](C)C(=O)[C@H](C)C[C@](C)(OC)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@H](C)C(=O)[C@](C)(F)C(=O)O[C@H](CC)[C@]21C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00005616_numbered.png,2026-03-19 06:56:04.684656
3161,ML00005846,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccc(F)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccccc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005846_numbered.png,2026-03-19 06:56:04.748851
3162,ML00007143,,,COC1/C=C/CC/C=C/C(=O)OC(C(C)C(=O)CCCC2CC(=O)NC(=O)C2)/C(C)=C/C(C)C1O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 6, 7, 8]",ring_size_14/standard/numbered/ML00007143_numbered.png,2026-03-19 06:56:04.783736
3163,ML00009800,,,C=C1NC[C@H](C)[C@H](CC[C@@H](C)C(=O)/C=C\C(C)=C/CC[C@@H](C)CCCCCC)OC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](C)CNC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3164,ML00003038,,,CO[C@@H]1C[C@H](C)O[C@H](O[C@H]2[C@H](C)C[C@@](C)(O)C(=O)[C@H](C)[C@@H](OC(C)=O)[C@H](C)[C@@H]([C@H](C)[C@H](C)O)OC(=O)[C@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@H](OC(C)=O)[C@@H](C)O3)[C@@H]2C)[C@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003038_numbered.png,2026-03-19 06:56:04.852951
3165,ML00008446,,,C=C1/C=C(\C)[C@H](CC)OC(=O)[C@H](C)C(=O)[C@@](O)(CO)C/C=C/[C@@H](C)C1,standard_macrolactone,14.0,,,success,,8.0,"[3, 4, 6, 8, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00008446_numbered.png,2026-03-19 06:56:04.897548
3166,ML00003455,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCCNCCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003455_numbered.png,2026-03-19 06:56:04.960047
3167,ML00004371,,,CCCCCCNNC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N/OCCCC3CCCCC3)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004371_numbered.png,2026-03-19 06:56:05.032251
3168,ML00000044,CHEMBL1668419,,COc1cc(O)c2c(c1)CCCCCC(=O)/C=C/C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00000044_numbered.png,2026-03-19 06:56:05.057243
3169,ML00006155,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccc4c(c3)OCO4)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006155_numbered.png,2026-03-19 06:56:05.122671
3170,ML00006177,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O/C=C\Cc2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cnc3ccccc3c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006177_numbered.png,2026-03-19 06:56:05.182767
3171,ML00007452,,,O=C1O[C@]2(Cc3ccc(cc3)Oc3cc(ccc3O)CCOC2=O)C(c2ccc(O)cc2)=C1O,non_standard_macrocycle,14.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
3172,ML00004246,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NC/C=C/c3ccc(N)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004246_numbered.png,2026-03-19 06:56:05.242622
3173,ML00005518,,,CC(=O)OC[C@]12[C@H](OC(=O)c3ccccc3)[C@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3174,ML00004712,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](OC(=O)C(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004712_numbered.png,2026-03-19 06:56:05.320493
3175,ML00005835,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(-c4cccc(N)n4)s3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005835_numbered.png,2026-03-19 06:56:05.380907
3176,ML00006776,,,C=C(C)/C=C/C/C=C/[C@H]1CC(=C)[C@@H]2O[C@H]2[C@H](O)C(=C)CC(=C)C(=C)CCC(=O)O1,standard_macrolactone,14.0,,,success,,6.0,"[3, 5, 8, 9, 11, 12]",ring_size_14/standard/numbered/ML00006776_numbered.png,2026-03-19 06:56:05.419752
3177,ML00005574,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CC(C)(C)C[C@@H]2c2ccc3c(c2)OCO3)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005574_numbered.png,2026-03-19 06:56:05.481187
3178,ML00006822,,,COc1cc(O)c2c(c1Br)C(=O)OCCN(C(=O)[C@@H](N)CC(C)C)CC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3179,ML00001801,CHEMBL1367454,,C[C@@H]1CCCCCCCCC(=O)OCCN1C(=O)OC(C)(C)C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3180,ML00006222,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006222_numbered.png,2026-03-19 06:56:05.559236
3181,ML00003750,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccc2[N+](=O)[O-])[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003750_numbered.png,2026-03-19 06:56:05.626006
3182,ML00004248,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)c2ccc([N+](=O)[O-])cc2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004248_numbered.png,2026-03-19 06:56:05.689163
3183,ML00005640,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cccnc2N)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005640_numbered.png,2026-03-19 06:56:05.748582
3184,ML00001752,CHEMBL1094532,,C[C@@H]1OC(=O)c2c(O)cc(OCCNc3ccccn3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001752_numbered.png,2026-03-19 06:56:05.782728
3185,ML00003358,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3186,ML00010247,,,COc1ccccc1C1CC(=O)Oc2cc3c(c(OC)c21)C(=O)OC(C)CCCC(=O)CCCC=C3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010247_numbered.png,2026-03-19 06:56:05.815146
3187,ML00005975,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(=O)c1cccnc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3188,ML00004341,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)c2cc([N+](=O)[O-])cc([N+](=O)[O-])c2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004341_numbered.png,2026-03-19 06:56:05.886180
3189,ML00006492,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/C=C/c2cccnc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006492_numbered.png,2026-03-19 06:56:05.945902
3190,ML00003703,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(=N)N)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003703_numbered.png,2026-03-19 06:56:06.011864
3191,ML00007369,,,C/C(=C\c1csc(C)n1)[C@H](O)C[C@H]1OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC[C@@]1(C)O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 4, 8, 9, 10, 11, 12, 12, 13]",ring_size_14/standard/numbered/ML00007369_numbered.png,2026-03-19 06:56:06.063402
3192,ML00000480,CHEMBL3734952,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000480_numbered.png,2026-03-19 06:56:06.115881
3193,ML00007017,,,C/C(=C\c1csc(C)n1)[C@@H]1C/C=C\CCC[C@H](C)C(=O)[C@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,14.0,,,success,,5.0,"[3, 10, 11, 12, 13]",ring_size_14/standard/numbered/ML00007017_numbered.png,2026-03-19 06:56:06.150707
3194,ML00002629,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCC(=O)NCCc2cccc3c2OCO3)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002629_numbered.png,2026-03-19 06:56:06.222167
3195,ML00003477,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003477_numbered.png,2026-03-19 06:56:06.282061
3196,ML00000866,CHEMBL431667,,CCN(CC)CC1CCCC(=O)OC[C@H](NC(=O)C(Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC2CCCCC2)[C@@H](O)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3197,ML00006441,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCN(C)c2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006441_numbered.png,2026-03-19 06:56:06.357221
3198,ML00004126,,,C=C1C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@H](CC)[C@@]2(C)OC(=O)N(Cc3ccccc3)[C@H]12,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004126_numbered.png,2026-03-19 06:56:06.414030
3199,ML00003158,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCOc3cccc4cccnc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003158_numbered.png,2026-03-19 06:56:06.468927
3200,ML00006272,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3ccc(-c4cn(CCC(=O)NO)nn4)cc3)C2O)C(C)(OC)CC(C)C(=O)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006272_numbered.png,2026-03-19 06:56:06.535353
3201,ML00001653,CHEMBL582870,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC2CCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001653_numbered.png,2026-03-19 06:56:06.602391
3202,ML00001835,CHEMBL1235084,,O=C1CCCC/C=C/CCOC(=O)c2c(O)cc(O)c(Cl)c2C1,standard_macrolactone,14.0,,,success,,1.0,[11],ring_size_14/standard/numbered/ML00001835_numbered.png,2026-03-19 06:56:06.625340
3203,ML00006336,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1cccnc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3204,ML00003815,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC(C)=O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003815_numbered.png,2026-03-19 06:56:06.699239
3205,ML00001945,CHEMBL121731,,O=C(/C=C/c1ccccc1)N[C@H]1COC(=O)CCC[C@H](CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3206,ML00002190,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CNC(=O)Nc3cnc4ccccc4c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002190_numbered.png,2026-03-19 06:56:06.762710
3207,ML00007087,,,CC[C@@H]1OC(=O)[C@H](C)[C@H](O)[C@H](C)C(=O)[C@H](C)C[C@@H](C)C(=O)[C@@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00007087_numbered.png,2026-03-19 06:56:06.824031
3208,ML00008357,,,COc1cc(O)c2c(c1Cl)/C=C\C[C@H](O)[C@H](O)[C@H](O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008357_numbered.png,2026-03-19 06:56:06.856493
3209,ML00007705,,,C[C@H]1C/C=C/C(O)C/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 11]",ring_size_14/standard/numbered/ML00007705_numbered.png,2026-03-19 06:56:06.884361
3210,ML00010599,,,COc1ccc2cc(C3CC(=O)Oc4cc5c(c(O)c43)C(=O)OC(C)CCCC(=O)CCCC=C5)c(=O)n(C)c2c1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010599_numbered.png,2026-03-19 06:56:06.909573
3211,ML00006913,,,C=C1/C=C(/CO)[C@H](CC)OC(=O)[C@H](C)C(=O)[C@](O)(CO)C/C(C)=C\[C@@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00006913_numbered.png,2026-03-19 06:56:06.956012
3212,ML00001570,CHEMBL574205,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001570_numbered.png,2026-03-19 06:56:07.021628
3213,ML00002184,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3c(O)ccc4ccccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00002184_numbered.png,2026-03-19 06:56:07.076941
3214,ML00004140,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC#Cc2cc(-c3cccnn3)no2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00004140_numbered.png,2026-03-19 06:56:07.138323
3215,ML00002764,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@H](OC/C(=N\OCc3ccc(-n4cccn4)nc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002764_numbered.png,2026-03-19 06:56:07.195459
3216,ML00004333,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3cccc(OC)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004333_numbered.png,2026-03-19 06:56:07.250940
3217,ML00005195,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNCCCc2ccccc2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005195_numbered.png,2026-03-19 06:56:07.320200
3218,ML00004095,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)C(C)C)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3219,ML00007715,,,COc1cc(O)c2c(c1Cl)C(=O)OCC(=O)NCC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3220,ML00007088,,,CC[C@@H]1OC(=O)[C@H](C)[C@H](O)[C@H](C)C(=O)[C@H](C)C[C@@H](C)C(=O)[C@@H](C)[C@@H](O)[C@@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00007088_numbered.png,2026-03-19 06:56:07.388636
3221,ML00003581,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](OCc3ccccc3)[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2OC(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003581_numbered.png,2026-03-19 06:56:07.446129
3222,ML00000801,CHEMBL1778052,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000801_numbered.png,2026-03-19 06:56:07.512227
3223,ML00006873,,,CO[C@H]1CC[C@@H](C)/C=C\CC/C(C)=C\C(=O)O[C@H](CC(=O)[C@H]2CSC(=O)N2)C1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 8, 13]",ring_size_14/standard/numbered/ML00006873_numbered.png,2026-03-19 06:56:07.551061
3224,ML00004361,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004361_numbered.png,2026-03-19 06:56:07.627976
3225,ML00001586,CHEMBL1269436,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCNC=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001586_numbered.png,2026-03-19 06:56:07.692944
3226,ML00006212,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](COCc3ccccc3)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cc(-c4cccc(N)c4)nn3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00006212_numbered.png,2026-03-19 06:56:07.756726
3227,ML00007960,,,C[C@H]1C/C=C/[C@@H](O)[C@@H](O)CC[C@H]2O[C@@H]2c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00007960_numbered.png,2026-03-19 06:56:07.789522
3228,ML00006808,,,C[C@H]1COC(=O)CCCC/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3229,ML00008099,,,O=C1/C=C\[C@@H](O)/C=C\C/C=C\CCC[C@@H](C(=O)O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 12]",ring_size_14/standard/numbered/ML00008099_numbered.png,2026-03-19 06:56:07.821448
3230,ML00006682,,,CCC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006682_numbered.png,2026-03-19 06:56:07.875440
3231,ML00008713,,,COc1cc(O)c2c(c1)[C@H](O)[C@@H](O)C[C@@H]1O[C@H]1C(=O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 11, 12]",ring_size_14/standard/numbered/ML00008713_numbered.png,2026-03-19 06:56:07.908314
3232,ML00006640,,,COc1cc(O)c2c(c1Br)C(=O)O[C@H](c1ccccc1)C(=O)NCC(=S)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3233,ML00001649,CHEMBL583094,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)Nc2ccncn2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001649_numbered.png,2026-03-19 06:56:07.980254
3234,ML00007819,,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007819_numbered.png,2026-03-19 06:56:08.006596
3235,ML00004449,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3ccc(-c4cn(CCCCCCC(=O)NO)nn4)cc3)C2O)C(C)(OC)CC(C)C(=O)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004449_numbered.png,2026-03-19 06:56:08.076342
3236,ML00005318,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCCCOCC#Cc3ccc4c(c3)CC(C(=O)O)=CN4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005318_numbered.png,2026-03-19 06:56:08.143599
3237,ML00008444,,,C/C1=C/C(=O)O[C@@H](C[C@H](O)[C@H]2CSC(=O)N2)C[C@H](O)CC[C@H](C)/C=C\CC1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 8, 13]",ring_size_14/standard/numbered/ML00008444_numbered.png,2026-03-19 06:56:08.177264
3238,ML00002393,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)/C=C/c2ccccc2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002393_numbered.png,2026-03-19 06:56:08.242292
3239,ML00006431,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](n2ccc(O)c2C(=O)OC(C)(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006431_numbered.png,2026-03-19 06:56:08.315704
3240,ML00008785,,,CO[C@H]1/C=C\[C@@](C)(O)CCC(=O)O[C@H](C)[C@@H](C)C[C@@H](O)/C=C\1C,standard_macrolactone,14.0,,,success,,7.0,"[3, 4, 6, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00008785_numbered.png,2026-03-19 06:56:08.360709
3241,ML00009117,,,C=CCO[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009117_numbered.png,2026-03-19 06:56:08.428582
3242,ML00009570,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/N=C2/O[C@@]1(C)[C@H](O)[C@H]2C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3243,ML00006726,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1ccco1)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00006726_numbered.png,2026-03-19 06:56:08.463611
3244,ML00003091,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)C2NC(COCCOC)OC(C2C)C1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003091_numbered.png,2026-03-19 06:56:08.521334
3245,ML00004655,,,CC[C@H]1OC(=O)[C@H](C)C(OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccnc4ccccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004655_numbered.png,2026-03-19 06:56:08.582720
3246,ML00001564,CHEMBL1774289,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001564_numbered.png,2026-03-19 06:56:08.651662
3247,ML00002517,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(-n4cccn4)nc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002517_numbered.png,2026-03-19 06:56:08.712954
3248,ML00003516,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCc2ccc(Cl)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003516_numbered.png,2026-03-19 06:56:08.781890
3249,ML00001599,CHEMBL1269448,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCc2nccs2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001599_numbered.png,2026-03-19 06:56:08.855925
3250,ML00007721,,,C[C@@H]1C[C@H]2O[C@H]2/C=C\C=C/C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007721_numbered.png,2026-03-19 06:56:08.883038
3251,ML00001627,CHEMBL40743,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001627_numbered.png,2026-03-19 06:56:08.942296
3252,ML00004430,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OCCNCCCOCCCCOCCCNCc2ccc3ccccc3c2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004430_numbered.png,2026-03-19 06:56:09.005552
3253,ML00006234,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccc3c(c2)OCO3)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nc4ccc(OC)nc4[nH]3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006234_numbered.png,2026-03-19 06:56:09.068621
3254,ML00000286,CHEMBL85730,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)NCC2CCCCC2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000286_numbered.png,2026-03-19 06:56:09.100342
3255,ML00007733,,,C[C@H]1C[C@H]2O[C@@H]2C[C@H](O)/C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 8, 11]",ring_size_14/standard/numbered/ML00007733_numbered.png,2026-03-19 06:56:09.128478
3256,ML00003157,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=C\C#Cc3ccc(N)cc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003157_numbered.png,2026-03-19 06:56:09.184350
3257,ML00006123,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nc4ccc(OC)nc4[nH]3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006123_numbered.png,2026-03-19 06:56:09.242729
3258,ML00006040,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NCCC2=C(C)CCCC2(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006040_numbered.png,2026-03-19 06:56:09.307524
3259,ML00009768,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3260,ML00001319,CHEMBL1269434,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCN)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001319_numbered.png,2026-03-19 06:56:09.379758
3261,ML00002201,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3cccnc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3262,ML00006745,,,CCCCCCC[C@@H]1CC(=O)N[C@@H](CO)C(=O)O[C@H](CCCCC)CC(=O)N[C@@H](CO)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3263,ML00004432,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)(CN(C)Cc3ccc(-c4cn(CCCC(=O)NO)nn4)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(OC)CC(C)C(=O)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004432_numbered.png,2026-03-19 06:56:09.458197
3264,ML00008750,,,CC/C=C\C[C@H]1/C=C\C=C/CCCCCCCC(=O)O1,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008750_numbered.png,2026-03-19 06:56:09.479521
3265,ML00004209,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)[C@@H](N(C)C)[C@H](C)[C@@H](O)[C@@]1(O)CO,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004209_numbered.png,2026-03-19 06:56:09.543828
3266,ML00003463,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccc2F)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003463_numbered.png,2026-03-19 06:56:09.607826
3267,ML00003078,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NCC(C)(C)CO)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003078_numbered.png,2026-03-19 06:56:09.671930
3268,ML00008695,,,CCCCC[C@@H]1CCCCC[C@@H](O)C[C@H](O)[C@H](O)/C=C/C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 9, 11, 12]",ring_size_14/standard/numbered/ML00008695_numbered.png,2026-03-19 06:56:09.703176
3269,ML00001816,CHEMBL1335015,,C[C@H]1CCCC(=O)CCC/C=C/c2c(O)cc(O)cc2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00001816_numbered.png,2026-03-19 06:56:09.727230
3270,ML00009013,,,COC1C[C@@H](O[C@@H]2C(C)C(=O)OC(C)C(C)C(O)C(C)C(=O)[C@@]3(CO3)CC(C)C(OC3OC(C)CC(N(C)C)C3O)C2C)OC(C)[C@@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009013_numbered.png,2026-03-19 06:56:09.780373
3271,ML00007347,,,COc1ccc(NC(=O)COc2cc3c(c(OC)c2)C(=O)OC(C)CCCC(=O)CCCCC3)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007347_numbered.png,2026-03-19 06:56:09.804991
3272,ML00006176,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)c2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006176_numbered.png,2026-03-19 06:56:09.864315
3273,ML00009307,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3274,ML00009467,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCCN2CCOCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009467_numbered.png,2026-03-19 06:56:09.934620
3275,ML00002877,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2C(NC(=O)CCc3cnc4ccccc4c3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002877_numbered.png,2026-03-19 06:56:09.990907
3276,ML00000646,CHEMBL1413967,,C[C@H]1COC(=O)CC=C[C@@H](C)[C@@H]2C=C[C@@H](O)[C@@H](COC1=O)O2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3277,ML00006017,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)C(C)C)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3278,ML00003125,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC2CC2c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003125_numbered.png,2026-03-19 06:56:10.062601
3279,ML00003195,,,CC(=O)OC[C@]12[C@H](OC(=O)c3ccccc3)[C@@H](OC(C)=O)[C@@H]3OC(=O)[C@@](C)(O)[C@H](C)c4ccncc4C(=O)OC[C@@]4(C)O[C@]1([C@@H](OC(C)=O)[C@@H]4[C@@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3280,ML00004342,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(N)nc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00004342_numbered.png,2026-03-19 06:56:10.130128
3281,ML00002247,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-n3cnnc3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002247_numbered.png,2026-03-19 06:56:10.190523
3282,ML00002528,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2ccc3nnccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002528_numbered.png,2026-03-19 06:56:10.247893
3283,ML00001090,CHEMBL1077368,,CC[C@@H]1C/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(OC)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001090_numbered.png,2026-03-19 06:56:10.279969
3284,ML00004089,,,CC(=O)OC[C@]12[C@H](OC(=O)C(C)(C)OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3285,ML00004640,,,CC[C@H]1OC(=O)[C@H](C)C(OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004640_numbered.png,2026-03-19 06:56:10.345142
3286,ML00003228,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3287,ML00004536,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@H]3O[C@H](COC(C)=O)[C@@H](OC(=O)c4ccccc4)[C@H](OC(C)=O)[C@H]3OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004536_numbered.png,2026-03-19 06:56:10.422489
3288,ML00007901,,,C[C@H]1CCC[C@@H](O)CCC/C=C\c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007901_numbered.png,2026-03-19 06:56:10.447308
3289,ML00004602,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNC2CCCCC2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004602_numbered.png,2026-03-19 06:56:10.512357
3290,ML00008172,,,O=C1OCC/C=C/[C@@H](O)[C@@H](O)CC/C=C/c2cc(O)cc(O)c21,standard_macrolactone,14.0,,,success,,2.0,"[7, 8]",ring_size_14/standard/numbered/ML00008172_numbered.png,2026-03-19 06:56:10.537654
3291,ML00006896,,,COc1cc2c(c(OC)c1)C(=O)O[C@@H](C)CCCC(=O)[C@@H](C)CC/C=C/2,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00006896_numbered.png,2026-03-19 06:56:10.565303
3292,ML00002457,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCn3cnc4c3c(=O)n(C)c(=O)n4C)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002457_numbered.png,2026-03-19 06:56:10.620831
3293,ML00008715,,,COc1cc(O)c2c(c1Br)C(=O)OCCCCC(=S)N[C@H](c1nc(CN)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3294,ML00000994,CHEMBL521387,,C/C1=C/[C@@H](C)C[C@@H](O)/C=C/CC/C=C/C(=O)O[C@@H]1[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1,standard_macrolactone,14.0,,,success,,4.0,"[3, 4, 6, 8]",ring_size_14/standard/numbered/ML00000994_numbered.png,2026-03-19 06:56:10.658266
3295,ML00004301,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\Oc3ccccc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004301_numbered.png,2026-03-19 06:56:10.714940
3296,ML00007669,,,C=C1/C=C\C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)O[C@@H]([C@@H](CCO)[C@@H](C)CCCCCC)C(=O)N1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3297,ML00002837,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ccncn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002837_numbered.png,2026-03-19 06:56:10.780240
3298,ML00004378,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](C)[C@@H](OCc4ccccc4)[C@H](N(C)C)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004378_numbered.png,2026-03-19 06:56:10.840433
3299,ML00006412,,,CC[C@H]1OC(=O)[C@H](C)C(O[C@H]2C[C@](C)(OC)[C@@H](O)[C@@H](C)O2)[C@H](C)C(O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCOc2ccccc2OC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006412_numbered.png,2026-03-19 06:56:10.906146
3300,ML00009585,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccncc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009585_numbered.png,2026-03-19 06:56:10.973052
3301,ML00000077,CHEMBL303274,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000077_numbered.png,2026-03-19 06:56:11.036553
3302,ML00005895,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Oc4ccccc4)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00005895_numbered.png,2026-03-19 06:56:11.092323
3303,ML00001045,CHEMBL1079086,,COc1cc(O)c2c(c1)/C=C/C[C@@H](O)[C@@H](O)C(=O)/C=C\C[C@@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001045_numbered.png,2026-03-19 06:56:11.124206
3304,ML00003118,,,C=CCO[C@@H]1C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCc2c[nH]c3ccccc23)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003118_numbered.png,2026-03-19 06:56:11.180090
3305,ML00003170,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NNCCc2ccc(-c3cnccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003170_numbered.png,2026-03-19 06:56:11.237084
3306,ML00004725,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCC(=O)NCc3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004725_numbered.png,2026-03-19 06:56:11.302147
3307,ML00009773,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3308,ML00002115,CHEMBL302689,,O=C(NC(Cc1ccccc1)C(O)CN1C/C=C\CCCCCCCCOC1=O)O[C@H]1CO[C@H]2OCC[C@@H]12,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3309,ML00010691,,,CC(=O)c1ccc(-c2ccc(C3CC(=O)Oc4cc5c(c(O)c43)C(=O)OC(C)CCCC(=O)CCCC=C5)o2)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010691_numbered.png,2026-03-19 06:56:11.340674
3310,ML00002880,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NCCOCc2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002880_numbered.png,2026-03-19 06:56:11.400311
3311,ML00003218,,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)N/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003218_numbered.png,2026-03-19 06:56:11.458349
3312,ML00010815,,,COc1cc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)ccc1OC(C)C,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010815_numbered.png,2026-03-19 06:56:11.483959
3313,ML00007153,,,CO[C@@H]1/C=C\CC/C=C\C(=O)O[C@H]([C@@H](C)C(=O)CCCC2CC(=O)NC(=O)C2)/C(C)=C\[C@H](C)[C@H]1O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 6, 7, 8]",ring_size_14/standard/numbered/ML00007153_numbered.png,2026-03-19 06:56:11.517912
3314,ML00001673,CHEMBL1094198,,CC(=O)NCCOc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001673_numbered.png,2026-03-19 06:56:11.551353
3315,ML00002345,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cc(-c4ccccn4)nn3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002345_numbered.png,2026-03-19 06:56:11.607201
3316,ML00006644,,,C/C=C/CNC(=N)NCCCCCCCCN1CCCCCOC(=O)CCNC(=N)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3317,ML00010962,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010962_numbered.png,2026-03-19 06:56:11.668367
3318,ML00001652,CHEMBL206297,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](OC(=O)CC(=O)N(C)CCN(C)C)[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001652_numbered.png,2026-03-19 06:56:11.732981
3319,ML00001600,CHEMBL584553,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCC(F)(F)F)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001600_numbered.png,2026-03-19 06:56:11.797453
3320,ML00002775,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccnc4ccccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002775_numbered.png,2026-03-19 06:56:11.853149
3321,ML00001655,CHEMBL583096,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCCCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001655_numbered.png,2026-03-19 06:56:11.917297
3322,ML00007936,,,C[C@@H]1C[C@@H](O)C/C=C\CCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 5, 11]",ring_size_14/standard/numbered/ML00007936_numbered.png,2026-03-19 06:56:11.945435
3323,ML00002875,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=C\c3cnc4ccccc4c3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002875_numbered.png,2026-03-19 06:56:12.001371
3324,ML00007590,,,CCCCCCC[C@H]1CC(=O)N[C@@H](CO)C(=O)O[C@@H](CCCCCCC)CC(=O)N[C@@H](CO)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3325,ML00004230,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)c2ccccc2O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004230_numbered.png,2026-03-19 06:56:12.069186
3326,ML00003176,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cnc3ccccc3c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00003176_numbered.png,2026-03-19 06:56:12.129025
3327,ML00006458,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3328,ML00008046,,,C[C@H]1CCC/C=C\[C@@H](O)[C@H]2O[C@H]2[C@@H](O)/C=C\C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 9, 12]",ring_size_14/standard/numbered/ML00008046_numbered.png,2026-03-19 06:56:12.165004
3329,ML00007625,,,COc1cc2c(c(OCC(=O)Nc3cccc(F)c3)c1)C(=O)OC(C)CCCC(=O)CCCCC2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007625_numbered.png,2026-03-19 06:56:12.189292
3330,ML00008513,,,COc1cc(O)c2c(c1C)C(=O)OCCCCC(=S)N[C@H](c1nc(CN)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3331,ML00003310,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3ccc(C#N)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003310_numbered.png,2026-03-19 06:56:12.246765
3332,ML00000033,CHEMBL1136,TELITHROMYCIN,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000033_numbered.png,2026-03-19 06:56:12.302497
3333,ML00003138,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-n3cccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00003138_numbered.png,2026-03-19 06:56:12.363036
3334,ML00003022,,,CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H]2[C@@H](OC(C)=O)[C@@]34O[C@@]2(C)COC(=O)c2cccnc2[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]13COC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3335,ML00008796,,,CCCCCC1/C=C/C(=O)CCCCCCCCC(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 6]",ring_size_14/standard/numbered/ML00008796_numbered.png,2026-03-19 06:56:12.395731
3336,ML00002220,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1cccnc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3337,ML00008696,,,CCCCC[C@@H]1CCCCC[C@@H](O)C[C@@H](O)[C@@H](O)/C=C/C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 9, 11, 12]",ring_size_14/standard/numbered/ML00008696_numbered.png,2026-03-19 06:56:12.434269
3338,ML00001883,CHEMBL1094363,PAECILOMYCIN A,COc1cc(O)c2c(c1)[C@@H]1O[C@@H]1C[C@H](O)[C@H](O)[C@H](O)/C=C/C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001883_numbered.png,2026-03-19 06:56:12.465317
3339,ML00008364,,,COc1cc(O)c2c(c1)/C=C\CC[C@H](O)[C@@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00008364_numbered.png,2026-03-19 06:56:12.492896
3340,ML00007784,,,C/C1=C/CC[C@H](C)[C@@H](C)OC(=O)CC[C@](C)(O)/C=C\[C@@H]1O,standard_macrolactone,14.0,,,success,,6.0,"[3, 4, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00007784_numbered.png,2026-03-19 06:56:12.529323
3341,ML00007874,,,C[C@H]1C/C=C/CCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007874_numbered.png,2026-03-19 06:56:12.553875
3342,ML00005954,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O/C=C\Cc2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005954_numbered.png,2026-03-19 06:56:12.611246
3343,ML00004406,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3ccc4c(=O)c(C(=O)O)cn(C5CC5)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004406_numbered.png,2026-03-19 06:56:12.677733
3344,ML00004693,,,CCCCC(=O)O[C@H]1[C@H](C)OC(O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc3ccccc3)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004693_numbered.png,2026-03-19 06:56:12.743537
3345,ML00001832,CHEMBL1316592,,C[C@H]1/C=C\CC(=O)OC[C@H](C)C(=O)N2CCC[C@@H]2C(=O)OC1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3346,ML00007602,,,Cc1ccc(C)c(COc2cc(O)c3c(c2)C=CCCCC(=O)CCCC(C)OC3=O)c1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007602_numbered.png,2026-03-19 06:56:12.774649
3347,ML00010880,,,CCCCCCC[C@@H]1CC(=O)N[C@@H](COC(C)=O)C(=O)O[C@H](CCCCCCC)CC(=O)N[C@@H](COC(C)=O)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3348,ML00004352,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3cccc(Cl)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004352_numbered.png,2026-03-19 06:56:12.832834
3349,ML00006115,,,CC/C=C/CN1C(=O)N(CCCCn2cnc(-c3cccnc3)c2)[C@@H]2[C@@H](C)C(=O)[C@H](C)C[C@](C)(OC)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@H](C)C(=O)[C@](C)(F)C(=O)O[C@H](CC)[C@]21C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00006115_numbered.png,2026-03-19 06:56:12.893398
3350,ML00002356,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC/C(=N\OCCc3ccccc3)CCO[C@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]3NC(=O)O[C@]13C)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00002356_numbered.png,2026-03-19 06:56:12.943530
3351,ML00001290,CHEMBL1269451,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCc2nc[nH]n2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001290_numbered.png,2026-03-19 06:56:13.009142
3352,ML00003659,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3353,ML00009298,,,COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C2=CCOC(=O)CC3C(C(=O)OC)=COC(OC4OC(CO)C(O)C(O)C4O)C3=CCOC(=O)CC12,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3354,ML00000017,CHEMBL1097999,E-6201,CCNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00000017_numbered.png,2026-03-19 06:56:13.058126
3355,ML00004871,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc(-c5ccc(N)nc5)c4)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004871_numbered.png,2026-03-19 06:56:13.117498
3356,ML00001679,CHEMBL1098081,,CCN(CC)c1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001679_numbered.png,2026-03-19 06:56:13.153571
3357,ML00001947,CHEMBL126047,,CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)N[C@H]1COC(=O)CCCCOC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3358,ML00004363,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](OC(=O)CC3CCCCC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004363_numbered.png,2026-03-19 06:56:13.227122
3359,ML00000715,CHEMBL1671904,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(OC)CC(C)C(=O)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000715_numbered.png,2026-03-19 06:56:13.292393
3360,ML00009955,,,C[C@@H]1OC(=O)c2c(O)cc(N(CCNCC(O)CO)C(=O)OC(C)(C)C)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00009955_numbered.png,2026-03-19 06:56:13.327363
3361,ML00000941,CHEMBL273536,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OCC2(C)C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000941_numbered.png,2026-03-19 06:56:13.386213
3362,ML00000806,CHEMBL365528,CETHROMYCIN,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000806_numbered.png,2026-03-19 06:56:13.443692
3363,ML00009656,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(=O)[C@H](C)[C@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@]1([C@H](O)[C@@H]4[C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3364,ML00010226,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C/[C@]1(C)O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010226_numbered.png,2026-03-19 06:56:13.503097
3365,ML00003954,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](O)[C@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3366,ML00006505,,,CC(=O)OC[C@]12[C@H](OC(=O)c3ccccc3)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3367,ML00008993,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)CCCNCc3nccs3)[C@@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00008993_numbered.png,2026-03-19 06:56:13.579433
3368,ML00004490,,,CCCCNNC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N/OCCCC3CCCCC3)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004490_numbered.png,2026-03-19 06:56:13.645381
3369,ML00000790,CHEMBL584551,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)N(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000790_numbered.png,2026-03-19 06:56:13.710734
3370,ML00006909,,,C=C1/C=C(/C)[C@@H](CC)OC(=O)[C@@H](C)C(=O)[C@](O)(CO)C/C(C)=C\[C@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00006909_numbered.png,2026-03-19 06:56:13.759026
3371,ML00004874,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3cccnc3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc(-c5cccnc5)c4)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004874_numbered.png,2026-03-19 06:56:13.818692
3372,ML00007446,,,CC1CCCC(=O)CCCC=Cc2cc(OCC(=O)c3ccccc3)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007446_numbered.png,2026-03-19 06:56:13.844285
3373,ML00009775,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3374,ML00010739,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=S)SC)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010739_numbered.png,2026-03-19 06:56:13.914822
3375,ML00006766,,,O=C1OCC/C=C/CC/C=C/C(=N/OCC(=O)N2CCCCC2)Cc2cc(OCOP(=O)(O)O)cc(O)c21,standard_macrolactone,14.0,,,success,,1.0,[11],ring_size_14/standard/numbered/ML00006766_numbered.png,2026-03-19 06:56:13.938493
3376,ML00008349,,,C[C@H]1CCCC(=O)[C@@H](C)CC/C=C/c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00008349_numbered.png,2026-03-19 06:56:13.966160
3377,ML00002644,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)c2ccc(OC)cc2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002644_numbered.png,2026-03-19 06:56:14.028069
3378,ML00004730,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCC(=O)NCc3ccc(F)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004730_numbered.png,2026-03-19 06:56:14.093912
3379,ML00005843,,,C=C[C@]12OC(=O)N(CCCCc3cnc(-c4cccnc4)s3)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005843_numbered.png,2026-03-19 06:56:14.151798
3380,ML00002422,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nc4ccccc4[nH]3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002422_numbered.png,2026-03-19 06:56:14.208944
3381,ML00004638,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OCCNCCCCCCNCc2cccc(Oc3ccccc3)c2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004638_numbered.png,2026-03-19 06:56:14.272496
3382,ML00003155,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NN(C)CCc2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003155_numbered.png,2026-03-19 06:56:14.330571
3383,ML00006083,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCC#Cc2cncc3ccccc23)[C@H](C)[C@@H](O[C@@H]2OCC[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2Cl)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006083_numbered.png,2026-03-19 06:56:14.389312
3384,ML00004480,,,CC[C@H]1OC(=O)[C@H](C)C(O/C=C\Cc2ccnc3ccccc23)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccnc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004480_numbered.png,2026-03-19 06:56:14.454683
3385,ML00006390,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006390_numbered.png,2026-03-19 06:56:14.519976
3386,ML00001256,CHEMBL335552,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccsc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001256_numbered.png,2026-03-19 06:56:14.577749
3387,ML00010738,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010738_numbered.png,2026-03-19 06:56:14.640461
3388,ML00005905,,,C=C[C@]12OC(=O)N(CCCCc3ccc(-c4cccnc4)s3)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005905_numbered.png,2026-03-19 06:56:14.697592
3389,ML00003007,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]3[C@H](OC(C)=O)[C@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@H]([C@@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3390,ML00008486,,,COc1cc(O)c2c(c1Br)C(=O)OCCN(C(C)=O)CC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3391,ML00008506,,,COc1cc(O)c2c(c1OC)/C=C\CCC(=O)[C@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00008506_numbered.png,2026-03-19 06:56:14.739421
3392,ML00007851,,,COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OCCOCC(=S)N1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3393,ML00009367,,,CC[C@H]1OC(=O)C[C@@H](O[C@H]2C[C@@](C)(O)[C@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13]",ring_size_14/standard/numbered/ML00009367_numbered.png,2026-03-19 06:56:14.802093
3394,ML00009549,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009549_numbered.png,2026-03-19 06:56:14.863352
3395,ML00001568,CHEMBL583095,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001568_numbered.png,2026-03-19 06:56:14.928321
3396,ML00000334,CHEMBL12282,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(F)c(Cl)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000334_numbered.png,2026-03-19 06:56:14.987689
3397,ML00006179,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2ccc(-n3ccnc3)cc2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006179_numbered.png,2026-03-19 06:56:15.047492
3398,ML00003650,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3399,ML00001854,CHEMBL3940603,,CCNc1cc(O)c2c(c1)C#CC[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001854_numbered.png,2026-03-19 06:56:15.088919
3400,ML00002413,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCC#Cc3ncccn3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002413_numbered.png,2026-03-19 06:56:15.145421
3401,ML00006757,,,CCCCC[C@@H](C[C@@H]1CC[C@@H](C)C(=O)N(C)/C=C\CC(=O)O[C@@H](C(C)C)C(=O)O1)OC,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3402,ML00006784,,,C/C=C1\C2OC=C(C(=O)OC)C1CC(=O)OCC(c1ccc(O)c(O)c1)OCC1OC(O2)C(O)C(O)C1O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3403,ML00002198,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCC#Cc3cccc(N)n3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002198_numbered.png,2026-03-19 06:56:15.216884
3404,ML00007439,,,Cc1ccc(COc2cc(O)c3c(c2)C=CCCCC(=O)CCCC(C)OC3=O)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007439_numbered.png,2026-03-19 06:56:15.241309
3405,ML00010225,,,CCC1OC(=O)C(C)C(=O)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)CC(C)C(=O)/C=C\C1(C)O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010225_numbered.png,2026-03-19 06:56:15.291754
3406,ML00010896,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](O)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(N)=O)C[C@@H](C)C(=O)[C@H](C)[C@@H]2NC(=S)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010896_numbered.png,2026-03-19 06:56:15.347160
3407,ML00009618,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC/C=C/c2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009618_numbered.png,2026-03-19 06:56:15.412197
3408,ML00009556,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009556_numbered.png,2026-03-19 06:56:15.477113
3409,ML00004226,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)c2ccccc2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004226_numbered.png,2026-03-19 06:56:15.540057
3410,ML00008912,,,CCCN1C(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]12,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00008912_numbered.png,2026-03-19 06:56:15.595920
3411,ML00006060,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCN(C)c2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006060_numbered.png,2026-03-19 06:56:15.661300
3412,ML00001234,CHEMBL1256534,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001234_numbered.png,2026-03-19 06:56:15.725706
3413,ML00002841,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2cnc3c(F)cccc3c2)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002841_numbered.png,2026-03-19 06:56:15.792350
3414,ML00005397,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@@H]4COC(c5ccccc5)O[C@H]4[C@H](O)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc4ncccc43)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005397_numbered.png,2026-03-19 06:56:15.855238
3415,ML00002244,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cncc3ccccc23)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002244_numbered.png,2026-03-19 06:56:15.913427
3416,ML00009901,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@](C)(OC)C[C@@H](C)C(=O)/C(C)=C/[C@]1(C)OC(=O)n1ccnc1,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009901_numbered.png,2026-03-19 06:56:15.973920
3417,ML00003165,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccnc4ccccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00003165_numbered.png,2026-03-19 06:56:16.034731
3418,ML00001821,CHEMBL3966477,,C[C@H]1CCC[C@@H](O)/C=C/C=C\C(=O)CCC(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 12]",ring_size_14/standard/numbered/ML00001821_numbered.png,2026-03-19 06:56:16.063390
3419,ML00007547,,,CC[C@H](/C=C(/C)[C@@H]1C[C@@H](OC)C[C@H](O)C(C)(C)C2=C[C@H](O)C[C@H](C[C@@H](O)[C@H](O)C(=O)O1)O2)CO,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3420,ML00009449,,,CC[C@@H]1OC(=O)C[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)[C@H](C)[C@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13]",ring_size_14/standard/numbered/ML00009449_numbered.png,2026-03-19 06:56:16.130214
3421,ML00007934,,,C[C@@H]1C[C@H]2O[C@H]2CC/C=C/[C@H](O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007934_numbered.png,2026-03-19 06:56:16.155719
3422,ML00001839,CHEMBL552123,,C[C@@H]1C[C@H]2O[C@@H]2C/C=C/CC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00001839_numbered.png,2026-03-19 06:56:16.180615
3423,ML00001220,CHEMBL1256535,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001220_numbered.png,2026-03-19 06:56:16.243962
3424,ML00003566,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NC/C=C/c3ccc([N+](=O)[O-])o3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003566_numbered.png,2026-03-19 06:56:16.297034
3425,ML00002421,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCn1ccc2ncccc21,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002421_numbered.png,2026-03-19 06:56:16.349614
3426,ML00002233,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cnc3ccccc3c2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002233_numbered.png,2026-03-19 06:56:16.412209
3427,ML00006965,,,CC[C@@H]1OC(=O)[C@H](C)[C@@H](O)/C(C)=C\C(=O)C[C@@H](C)[C@H](O)/C(C)=C\[C@H]1C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 7, 8, 10, 12, 13, 14]",ring_size_14/standard/numbered/ML00006965_numbered.png,2026-03-19 06:56:16.462050
3428,ML00001956,CHEMBL3577623,,C#CCO[C@@H]1[C@@H](C)[C@H](OC(=O)NCCCNC(=N)NC(=O)NC)[C@@H](C)C(=O)O[C@H](CC)C(C)(C)[C@H](O)[C@@H](C)[C@@H](O)[C@H](C)C[C@@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001956_numbered.png,2026-03-19 06:56:16.523595
3429,ML00003646,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3430,ML00001239,CHEMBL1256544,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001239_numbered.png,2026-03-19 06:56:16.594014
3431,ML00002186,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=C\C#Cc3cccnc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002186_numbered.png,2026-03-19 06:56:16.650324
3432,ML00007848,,,CC1CCCC(=O)CCCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007848_numbered.png,2026-03-19 06:56:16.674655
3433,ML00010578,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@H]2N(N)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010578_numbered.png,2026-03-19 06:56:16.729731
3434,ML00002977,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2C(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3435,ML00008511,,,COc1cc(O)c2c(c1)/C=C/CC[C@H](C)C(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00008511_numbered.png,2026-03-19 06:56:16.764853
3436,ML00003951,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3437,ML00003949,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3438,ML00006113,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OCCNCCCNCc2ccc(Oc3ccccc3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006113_numbered.png,2026-03-19 06:56:16.841347
3439,ML00009704,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1C(C)C(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3440,ML00007746,,,C[C@H]1C/C=C\C(=O)[C@@H](O)[C@@H](O)C[C@H]2O[C@@H]2c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00007746_numbered.png,2026-03-19 06:56:16.879801
3441,ML00000452,CHEMBL1492454,,CCOC(=O)CCC(=O)O[C@H]1C(O[C@@H]2C(C)[C@H](O[C@H]3C[C@@](C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)[C@@](C)(O)C(O)[C@H](C)C(=O)C(C)C[C@]2(C)O)OC(C)CC1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000452_numbered.png,2026-03-19 06:56:16.942624
3442,ML00008004,,,C[C@@H]1C/C=C\C(=O)O[C@H](C)C[C@@H](O)[C@H](O)/C=C\C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3443,ML00007740,,,C[C@@H]1C/C=C\[C@@H](O)C/C=C\C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 11]",ring_size_14/standard/numbered/ML00007740_numbered.png,2026-03-19 06:56:16.975974
3444,ML00000051,CHEMBL1237072,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@@H]2N[C@@H](COCCOC)O[C@H]([C@H]2C)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000051_numbered.png,2026-03-19 06:56:17.033243
3445,ML00009661,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3446,ML00005624,,,C=C[C@]12OC(=O)N(CCCCn3cnc(-c4ccc(N(C)C)nc4)c3)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005624_numbered.png,2026-03-19 06:56:17.098035
3447,ML00006633,,,O=C1OCC/C=C/CC/C=C/C(=N/OCC(=O)N2CCCCC2)Cc2c(Cl)c(OP(=O)(O)O)cc(O)c21,standard_macrolactone,14.0,,,success,,1.0,[11],ring_size_14/standard/numbered/ML00006633_numbered.png,2026-03-19 06:56:17.120844
3448,ML00009469,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCCN2CCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009469_numbered.png,2026-03-19 06:56:17.183235
3449,ML00006630,,,O=C1OCC/C=C/CC/C=C/C(=N/OCC(=O)N2CCCCC2)Cc2c(Cl)c(O)cc(O)c21,standard_macrolactone,14.0,,,success,,1.0,[11],ring_size_14/standard/numbered/ML00006630_numbered.png,2026-03-19 06:56:17.206326
3450,ML00003315,,,CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H]2[C@@H](OC(C)=O)[C@@]34O[C@@]2(C)COC(=O)c2cnccc2[C@H](C)[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]13COC(=O)c1ccoc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3451,ML00009753,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(=O)[C@H](C)[C@@H](C)c4ncccc4C(=O)OC[C@@]4(C)O[C@@]1([C@@H](OC(C)=O)[C@H]4C(=O)[C@@H]2OC(C)=O)[C@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3452,ML00003150,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CNC(=O)OCc3ccc4ncccc4c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003150_numbered.png,2026-03-19 06:56:17.276532
3453,ML00003661,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3ccc(O)c(O)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003661_numbered.png,2026-03-19 06:56:17.330580
3454,ML00001042,CHEMBL3334714,,COc1cc(O)cc2c1C(=O)O[C@@H](C)CC[C@@H](O)CC/C=C/C(=O)C2,standard_macrolactone,14.0,,,success,,3.0,"[3, 6, 11]",ring_size_14/standard/numbered/ML00001042_numbered.png,2026-03-19 06:56:17.358503
3455,ML00007834,,,CC1CC/C=C(/CO)C(O)/C=C\C(C)(O)CCC(=O)OC1C,standard_macrolactone,14.0,,,success,,6.0,"[3, 4, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00007834_numbered.png,2026-03-19 06:56:17.395019
3456,ML00003153,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCc3cnc4ccccc4c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003153_numbered.png,2026-03-19 06:56:17.447208
3457,ML00011008,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3O[C@@](O)(C2)[C@H](C)C(=O)O[C@@H](/C=C/C=C/Br)C[C@@H](C)C/C=C\[C@H](O)[C@@H]3C)[C@H](OC)[C@@H]1OC,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3458,ML00005730,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2C(NC(=O)/C=C/CCc3cnc4ccccc4c3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005730_numbered.png,2026-03-19 06:56:17.509866
3459,ML00008477,,,COc1cc(O)c2c(c1)[C@H]1O[C@@H]1C[C@H](O)[C@H](OC)C(=O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008477_numbered.png,2026-03-19 06:56:17.541834
3460,ML00005942,,,C=C[C@]12OC(=O)N(CCCCn3cnc(-c4ccc(OC)nc4)c3)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005942_numbered.png,2026-03-19 06:56:17.598590
3461,ML00008710,,,COc1cc(O)c2c(c1)CCCC(=O)C(=O)C(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008710_numbered.png,2026-03-19 06:56:17.630140
3462,ML00007038,,,C=C1/C=C(/C)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@](O)(CO)C/C(OC)=C\[C@@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00007038_numbered.png,2026-03-19 06:56:17.678033
3463,ML00006049,,,CC[C@@H]1OC(=O)[C@@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC(C)=O)[C@H](OC(C)=O)[C@H](C)O2)[C@@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@@](C)(O[C@H]2C[C@H](N(C)C)[C@H](O)[C@H](C)O2)C[C@@H](C)C(=O)[C@H](O)[C@@H](O)C1(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006049_numbered.png,2026-03-19 06:56:17.744940
3464,ML00009281,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@](C)(OC)C[C@@H](C)C(=O)[C@]2(CC=NN2)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009281_numbered.png,2026-03-19 06:56:17.799190
3465,ML00002149,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NCc2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2CC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002149_numbered.png,2026-03-19 06:56:17.856722
3466,ML00006746,,,CCCCCCC[C@H]1CC(=O)N[C@@H](CO)C(=O)O[C@H](CCCCC)CC(=O)N[C@@H](CO)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3467,ML00000404,CHEMBL85612,,CCN(CC)c1ccc(NC(=O)CO/N=C2\C=C\C=C/[C@H]3O[C@@H]3C[C@@H](C)OC(=O)c3c(O)cc(O)c(Cl)c3C2)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000404_numbered.png,2026-03-19 06:56:17.887713
3468,ML00010583,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NN)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010583_numbered.png,2026-03-19 06:56:17.942733
3469,ML00003577,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003577_numbered.png,2026-03-19 06:56:17.995448
3470,ML00003174,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc3ncccc3c2)C[C@@H](C)/C(=N\O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00003174_numbered.png,2026-03-19 06:56:18.055653
3471,ML00008509,,,COc1cc2c(c(OC)c1)C(=O)O[C@@H](C)CCCC(=O)CCC/C=C/2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008509_numbered.png,2026-03-19 06:56:18.080162
3472,ML00007724,,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007724_numbered.png,2026-03-19 06:56:18.104266
3473,ML00009497,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1ccc(OCc2ccc(C(C)C)cc2)cc1)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00009497_numbered.png,2026-03-19 06:56:18.128945
3474,ML00001827,CHEMBL3980956,,CO[C@H]1/C=C\CCC[C@H](C)OC(=O)/C=C/C(=O)/C=C\1,standard_macrolactone,14.0,,,success,,3.0,"[3, 9, 12]",ring_size_14/standard/numbered/ML00001827_numbered.png,2026-03-19 06:56:18.156492
3475,ML00003260,,,CC[C@H]1OC(=O)[C@H](C)C(=O)C[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)CCC(=O)C[C@H]2[C@@H]1OC(=O)N2CCCCn1cnc(-c2cccnc2)c1,standard_macrolactone,14.0,,,success,,7.0,"[3, 7, 10, 10, 11, 13, 14]",ring_size_14/standard/numbered/ML00003260_numbered.png,2026-03-19 06:56:18.199218
3476,ML00005974,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(=O)c1cccnc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3477,ML00006730,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3ccc(Cl)cc3Cl)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00006730_numbered.png,2026-03-19 06:56:18.230643
3478,ML00002805,,,CC[C@H]1/C=C\CCC[C@@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 9, 10, 11]",ring_size_14/standard/numbered/ML00002805_numbered.png,2026-03-19 06:56:18.264350
3479,ML00006562,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006562_numbered.png,2026-03-19 06:56:18.328140
3480,ML00002760,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCc1ncc(-c2cccc(N)c2)s1,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002760_numbered.png,2026-03-19 06:56:18.381068
3481,ML00008756,,,COC1C=CC(C)(O)C=CC(=O)OC(C)C(C)CCC=C1C,standard_macrolactone,14.0,,,success,,6.0,"[3, 4, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00008756_numbered.png,2026-03-19 06:56:18.417924
3482,ML00004277,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004277_numbered.png,2026-03-19 06:56:18.480905
3483,ML00001650,CHEMBL572997,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)Nc2cnccn2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001650_numbered.png,2026-03-19 06:56:18.545445
3484,ML00001241,CHEMBL1778154,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001241_numbered.png,2026-03-19 06:56:18.608914
3485,ML00004890,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OCCNCCCOCCOCCCNc2ccc(Oc3ccccc3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004890_numbered.png,2026-03-19 06:56:18.671459
3486,ML00010575,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@H]2N(N)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00010575_numbered.png,2026-03-19 06:56:18.729914
3487,ML00010825,,,COc1cc(C2CC(=O)Oc3cc4c(c(OC)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc2c1OCCO2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010825_numbered.png,2026-03-19 06:56:18.760865
3488,ML00005520,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@@H](O)[C@@H]2OC(=O)c1ccccc1)[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3489,ML00003152,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=C\C=C\c3cccc([N+](=O)[O-])c3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003152_numbered.png,2026-03-19 06:56:18.825205
3490,ML00009767,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3491,ML00003211,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3492,ML00009746,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](NCCNCCNCc3nccs3)[C@@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009746_numbered.png,2026-03-19 06:56:18.900673
3493,ML00006783,,,CC1CCCC(=O)CCCCCc2cc(OCc3ccccc3)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00006783_numbered.png,2026-03-19 06:56:18.925573
3494,ML00001210,CHEMBL1778054,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001210_numbered.png,2026-03-19 06:56:18.989781
3495,ML00006070,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](COCc3ccccc3)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cc(-c4ccccn4)nn3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006070_numbered.png,2026-03-19 06:56:19.048214
3496,ML00006957,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006957_numbered.png,2026-03-19 06:56:19.099059
3497,ML00004232,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCNCc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004232_numbered.png,2026-03-19 06:56:19.152099
3498,ML00002178,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C/C=C/Cn3cnc4cccnc43)C(=O)N(C)[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002178_numbered.png,2026-03-19 06:56:19.211297
3499,ML00003209,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccc(=O)n(C)c1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3500,ML00008992,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCCN2CCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00008992_numbered.png,2026-03-19 06:56:19.281924
3501,ML00001572,CHEMBL1269442,,CCNC(=S)NCCO[C@H]1[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001572_numbered.png,2026-03-19 06:56:19.346838
3502,ML00003366,,,CC(=O)O[C@@H]1C(=O)[C@@H]2[C@@H](OC(C)=O)[C@@]34O[C@@]2(C)COC(=O)c2cccnc2C(C)C(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]13COC(=O)c1ccco1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3503,ML00004811,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004811_numbered.png,2026-03-19 06:56:19.414126
3504,ML00009612,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCCNCc2ccncc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009612_numbered.png,2026-03-19 06:56:19.477980
3505,ML00005840,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NN(C)CCc2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005840_numbered.png,2026-03-19 06:56:19.536671
3506,ML00002375,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCC[C@@H]2c2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002375_numbered.png,2026-03-19 06:56:19.595952
3507,ML00003417,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCc2ccc(O)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003417_numbered.png,2026-03-19 06:56:19.659881
3508,ML00007995,,,C[C@H]1CC[C@H](O)/C=C\C(=O)O[C@@H](C)[C@@H](O)CCC(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3509,ML00004635,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OCCNCC2CCC(CNCc3ccc(Oc4ccccc4)cc3)CC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004635_numbered.png,2026-03-19 06:56:19.729135
3510,ML00002415,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)/C(C)=C/[C@]1(C)OC(=O)NCCCSc1nc2cc([N+](=O)[O-])ccc2[nH]1,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002415_numbered.png,2026-03-19 06:56:19.788160
3511,ML00005659,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005659_numbered.png,2026-03-19 06:56:19.849341
3512,ML00010969,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3O[C@@](O)(C2)[C@@H](C)C(=O)O[C@@H](/C=C\C=C\Br)C[C@@H](C)C/C=C\[C@H](O)[C@@H]3C)[C@H](OC)[C@@H]1OC,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3513,ML00004351,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004351_numbered.png,2026-03-19 06:56:19.908348
3514,ML00003467,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3cccnc3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003467_numbered.png,2026-03-19 06:56:19.972870
3515,ML00002649,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)c2cccc(C)c2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002649_numbered.png,2026-03-19 06:56:20.035303
3516,ML00010197,,,COc1ccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1OCC(N)=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010197_numbered.png,2026-03-19 06:56:20.060585
3517,ML00003112,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccc(-c3ccccn3)s2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003112_numbered.png,2026-03-19 06:56:20.116205
3518,ML00002127,CHEMBL2234867,RIPOSTATIN,C/C(=C\Cc1ccccc1)CCC(=O)C[C@H]1C[C@H](O)C/C(C)=C/C/C=C/C/C(CC(=O)O)=C\C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 7, 13]",ring_size_14/standard/numbered/ML00002127_numbered.png,2026-03-19 06:56:20.148454
3519,ML00009197,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)C(=O)[C@H](C)C(OC/C=C/CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009197_numbered.png,2026-03-19 06:56:20.203823
3520,ML00010706,,,C=CCO[C@@]1(C)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010706_numbered.png,2026-03-19 06:56:20.266827
3521,ML00006898,,,CO[C@@H]1CC[C@H](C)/C=C\CC/C(C)=C\C(=O)O[C@@H](CC(=O)[C@H]2CSC(=O)N2)C1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 8, 13]",ring_size_14/standard/numbered/ML00006898_numbered.png,2026-03-19 06:56:20.299030
3522,ML00007783,,,C/C1=C/CCC(C)C(C)OC(=O)CCC(C)(O)/C=C\C1O,standard_macrolactone,14.0,,,success,,6.0,"[3, 4, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00007783_numbered.png,2026-03-19 06:56:20.335447
3523,ML00009441,,,CC[C@@H]1OC(=O)C[C@@H](O[C@H]2C[C@@](C)(OC)[C@H](O)[C@@H](C)O2)[C@H](C)[C@H](O[C@@H]2O[C@@H](C)C[C@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13]",ring_size_14/standard/numbered/ML00009441_numbered.png,2026-03-19 06:56:20.392118
3524,ML00008089,,,C[C@@H]1C/C=C\C(=O)O[C@H](C)CC[C@H](O)/C=C\C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3525,ML00005979,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005979_numbered.png,2026-03-19 06:56:20.463823
3526,ML00009430,,,O=C1CCC[C@H](CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2)CO1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3527,ML00004178,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC=O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004178_numbered.png,2026-03-19 06:56:20.536328
3528,ML00001607,CHEMBL1269439,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCNC(=O)OC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001607_numbered.png,2026-03-19 06:56:20.605748
3529,ML00002419,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=N\OCc3cc(-c4ncc[nH]4)no3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002419_numbered.png,2026-03-19 06:56:20.663324
3530,ML00004258,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3ccc(N(C)C)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004258_numbered.png,2026-03-19 06:56:20.716525
3531,ML00004701,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCC(=O)NCCc3ccccc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004701_numbered.png,2026-03-19 06:56:20.792873
3532,ML00007176,,,CC(C)(C)[C@H]1COC(=O)CCCC/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3533,ML00007418,,,CCCCCCCC[C@@H]1CC(=O)N[C@@H](CO)C(=O)O[C@H](CCCCCCC)CC(=O)N[C@@H](CO)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3534,ML00007768,,,C[C@@H]1C[C@@H]2O[C@@H]2C=CC=CC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007768_numbered.png,2026-03-19 06:56:20.828952
3535,ML00004581,,,CCCCCCCCC(=O)O[C@H]1[C@H](C)OC(O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc3ccccc3)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004581_numbered.png,2026-03-19 06:56:20.893668
3536,ML00001941,CHEMBL338891,,O=C1CCC[C@H](CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)CO1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3537,ML00002252,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#CCc2ccc(-c3csnn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002252_numbered.png,2026-03-19 06:56:20.957516
3538,ML00003574,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003574_numbered.png,2026-03-19 06:56:21.016111
3539,ML00009279,,,C=C1CO[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(C[C@@H](C)C(=O)[C@H](C)[C@@H]3NC(=O)O[C@]3(C)[C@@H](CC)OC(=O)[C@@H]2C)OC1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00009279_numbered.png,2026-03-19 06:56:21.066079
3540,ML00008533,,,COc1cc(O)c2c(c1Cl)C[C@@H](O)/C=C/CC[C@H]1O[C@@H]1C[C@@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00008533_numbered.png,2026-03-19 06:56:21.092057
3541,ML00004710,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004710_numbered.png,2026-03-19 06:56:21.156420
3542,ML00000928,CHEMBL429949,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000928_numbered.png,2026-03-19 06:56:21.215222
3543,ML00006340,,,CC(=O)OC[C@]12[C@H](OC(=O)C(C)C)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2OC(=O)C(C)C)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3544,ML00008363,,,COc1cc(O)cc2c1C(=O)O[C@@H](C)CCC[C@@H](O)[C@@H](O)CC/C=C/2,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00008363_numbered.png,2026-03-19 06:56:21.250760
3545,ML00001904,CHEMBL3933684,,C[C@@H]1OC(=O)c2c(O)cc(NCCN3CCN(C)CC3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001904_numbered.png,2026-03-19 06:56:21.283504
3546,ML00009354,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3547,ML00006962,,,CC[C@@H]1OC(=O)[C@H](C)[C@H](O)C(=O)C/C(C)=C\[C@H](C)[C@@H](O)/C(C)=C\[C@H]1C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 7, 8, 10, 12, 13, 14]",ring_size_14/standard/numbered/ML00006962_numbered.png,2026-03-19 06:56:21.336552
3548,ML00005661,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005661_numbered.png,2026-03-19 06:56:21.401563
3549,ML00004412,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004412_numbered.png,2026-03-19 06:56:21.467521
3550,ML00002360,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccc3c(c2)CCC3=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002360_numbered.png,2026-03-19 06:56:21.530428
3551,ML00006967,,,C[C@H]1C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C)OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006967_numbered.png,2026-03-19 06:56:21.583067
3552,ML00010486,,,CC(=O)OC[C@]12[C@H](O)C(=O)[C@@H]3[C@@H](O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3553,ML00010493,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3ccccc3)cc(OCC(O)CN3CCOCC3)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010493_numbered.png,2026-03-19 06:56:21.614732
3554,ML00002374,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCC[C@H]2c2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002374_numbered.png,2026-03-19 06:56:21.672899
3555,ML00001782,CHEMBL3973244,,C[C@@H]1OC(=O)c2c(O)cc(NCCN3CCCC3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001782_numbered.png,2026-03-19 06:56:21.706824
3556,ML00000590,CHEMBL487426,,C/C1=C/[C@@H](C)CC/C=C/CC/C=C/C(=O)O[C@@H]1[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1,standard_macrolactone,14.0,,,success,,3.0,"[3, 4, 6]",ring_size_14/standard/numbered/ML00000590_numbered.png,2026-03-19 06:56:21.734833
3557,ML00007397,,,CSc1ccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007397_numbered.png,2026-03-19 06:56:21.760117
3558,ML00008709,,,COc1cc(O)c2c(c1Br)C(=O)OCCCCC(=S)N[C@H](c1nc(CN)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3559,ML00003876,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2c(C)cc(C)cc2C)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003876_numbered.png,2026-03-19 06:56:21.828636
3560,ML00007988,,,C[C@H]1C[C@H](O)CCCC/C=C\CCCC(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 5]",ring_size_14/standard/numbered/ML00007988_numbered.png,2026-03-19 06:56:21.853201
3561,ML00004268,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2F)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004268_numbered.png,2026-03-19 06:56:21.916387
3562,ML00005958,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2OCC[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#CCC2CC(c3cnc4ccccc4c3)=NO2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005958_numbered.png,2026-03-19 06:56:21.973247
3563,ML00004838,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCCCc2ccc(NC(=O)Cc3ccccn3)nc2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004838_numbered.png,2026-03-19 06:56:22.032455
3564,ML00007588,,,CC[C@H](/C=C(\C)[C@@H]1C[C@@H](OC)C[C@H](O)C(C)(C)[C@@]2(O)O[C@@H](C[C@@H](O)[C@H](O)C(=O)O1)C[C@@H](OC)[C@H]2O)CO,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3565,ML00009447,,,CC[C@H]1OC(=O)C[C@@H](O[C@H]2C[C@@](C)(OC)[C@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13]",ring_size_14/standard/numbered/ML00009447_numbered.png,2026-03-19 06:56:22.098529
3566,ML00002778,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCn1cnc(-c2ccccc2)c1,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002778_numbered.png,2026-03-19 06:56:22.151291
3567,ML00008728,,,COc1cc(O)c2c(c1)C=CCCCC(=O)C=CC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008728_numbered.png,2026-03-19 06:56:22.175536
3568,ML00001769,CHEMBL562187,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N\OCc2ccccc2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00001769_numbered.png,2026-03-19 06:56:22.200788
3569,ML00009772,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3570,ML00007971,,,C[C@@H]1CCCC(=O)CCCC(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 11]",ring_size_14/standard/numbered/ML00007971_numbered.png,2026-03-19 06:56:22.234781
3571,ML00008398,,,COc1cc2c(c(OC)c1)C(=O)O[C@@H](C)CCC[C@@H](O)CCC/C=C/2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008398_numbered.png,2026-03-19 06:56:22.258703
3572,ML00010256,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3ccc4ccccc4c3)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010256_numbered.png,2026-03-19 06:56:22.283363
3573,ML00003797,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)C(O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCOc2ccc(OC)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003797_numbered.png,2026-03-19 06:56:22.345782
3574,ML00007417,,,CC[C@@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@H](O)[C@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00007417_numbered.png,2026-03-19 06:56:22.404636
3575,ML00010709,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2C(N)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010709_numbered.png,2026-03-19 06:56:22.460333
3576,ML00010184,,,COc1ccc(C2CC(=O)Oc3cc4c(c(OC)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1OC,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010184_numbered.png,2026-03-19 06:56:22.485987
3577,ML00009845,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCCC2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009845_numbered.png,2026-03-19 06:56:22.542798
3578,ML00004336,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccc3F)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004336_numbered.png,2026-03-19 06:56:22.606919
3579,ML00008526,,,COc1cc(O)c2c(c1C)C(=O)OCCCCC(=S)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3580,ML00002142,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(N)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002142_numbered.png,2026-03-19 06:56:22.670278
3581,ML00003198,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3582,ML00003992,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](OC(=O)c1ccco1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3583,ML00004250,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccccc3[N+](=O)[O-])C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004250_numbered.png,2026-03-19 06:56:22.737980
3584,ML00006421,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O[C@H]2C[C@@H](N(C)C)[C@@H](O)[C@H](C)O2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006421_numbered.png,2026-03-19 06:56:22.804524
3585,ML00000154,CHEMBL85011,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000154_numbered.png,2026-03-19 06:56:22.830478
3586,ML00003334,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003334_numbered.png,2026-03-19 06:56:22.894060
3587,ML00009710,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1C(C)C(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3588,ML00003354,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14OC3(C)COC(=O)c1cccnc1[C@H](C)[C@@H](C)C(=O)O[C@H]([C@H](O)[C@@H]2OC(=O)c1ccccc1)C4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3589,ML00007754,,,C[C@H]1C/C=C\C(=O)CCC/C=C\c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007754_numbered.png,2026-03-19 06:56:22.932516
3590,ML00006732,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1ccsc1)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00006732_numbered.png,2026-03-19 06:56:22.957025
3591,ML00004590,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc4ncccc43)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004590_numbered.png,2026-03-19 06:56:23.017594
3592,ML00004267,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCCc2ccc(F)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004267_numbered.png,2026-03-19 06:56:23.081367
3593,ML00000158,CHEMBL1668414,,COc1cc(O)c2c(c1)/C=C/CCCC(=O)C[C@H](Br)C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 5, 7]",ring_size_14/standard/numbered/ML00000158_numbered.png,2026-03-19 06:56:23.108933
3594,ML00004827,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(-c5cccc(Cl)c5O)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004827_numbered.png,2026-03-19 06:56:23.174972
3595,ML00009306,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@H]4C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3596,ML00001066,CHEMBL1097787,AIGIALOMYCIN B,COc1cc(O)c2c(c1)[C@@H]1O[C@@H]1C[C@H](O)[C@H](O)[C@@H](O)/C=C/C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001066_numbered.png,2026-03-19 06:56:23.213300
3597,ML00004358,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=N\OCc3cc(-c4ccccc4[N+](=O)[O-])no3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004358_numbered.png,2026-03-19 06:56:23.271318
3598,ML00002859,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3cccnc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)C(C)C)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3599,ML00010614,,,CC[C@H]1OC(=O)[C@H](C)C[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00010614_numbered.png,2026-03-19 06:56:23.338366
3600,ML00009506,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)[C@@H]2OC(=O)O[C@H]([C@H]2C)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009506_numbered.png,2026-03-19 06:56:23.396372
3601,ML00008697,,,CCCCC[C@H]1CCCCC[C@H](O)C[C@@H](O)[C@H](O)/C=C/C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 9, 11, 12]",ring_size_14/standard/numbered/ML00008697_numbered.png,2026-03-19 06:56:23.427149
3602,ML00002526,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccncc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002526_numbered.png,2026-03-19 06:56:23.484442
3603,ML00009280,,,C=CCO[C@]1(C)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C)C(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009280_numbered.png,2026-03-19 06:56:23.540618
3604,ML00006570,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006570_numbered.png,2026-03-19 06:56:23.606855
3605,ML00004274,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccc(OC)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004274_numbered.png,2026-03-19 06:56:23.673997
3606,ML00004445,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCCC(=O)NCCc3ccccc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004445_numbered.png,2026-03-19 06:56:23.773786
3607,ML00002407,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)/C=C/c2ccc(O)cc2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002407_numbered.png,2026-03-19 06:56:23.847745
3608,ML00001706,CHEMBL1321422,,C[C@H]1COC(=O)[C@H]2CCCN2C(=O)[C@@H](C)COC(=O)[C@H](Cc2ccccc2)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3609,ML00005860,,,C=C[C@]12OC(=O)N(CCCC(C)(C)n3cnc4ncccc43)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005860_numbered.png,2026-03-19 06:56:23.921281
3610,ML00003159,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCc1ccc2ccccc2n1,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003159_numbered.png,2026-03-19 06:56:23.986115
3611,ML00006369,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#CCCc2ccc(-c3cccs3)cc2)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006369_numbered.png,2026-03-19 06:56:24.050233
3612,ML00002960,,,CCCCCCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002960_numbered.png,2026-03-19 06:56:24.124255
3613,ML00001046,CHEMBL1079087,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\C[C@@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001046_numbered.png,2026-03-19 06:56:24.160723
3614,ML00007927,,,CC1C[C@H]2O[C@@H]2CCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007927_numbered.png,2026-03-19 06:56:24.189404
3615,ML00008093,,,C[C@@H]1C/C=C\C(=O)O[C@H](C)C[C@@H](O)C(=O)/C=C\C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3616,ML00007941,,,C[C@@H]1C/C=C/CCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007941_numbered.png,2026-03-19 06:56:24.223909
3617,ML00000260,CHEMBL404204,MONOCILLIN III,C[C@@H]1C[C@H]2O[C@@H]2CC/C=C/C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000260_numbered.png,2026-03-19 06:56:24.251837
3618,ML00003106,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CNC(=O)NCc3ccc4cccnc4c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003106_numbered.png,2026-03-19 06:56:24.314080
3619,ML00008510,,,COc1cc2c(c(OC)c1)C(=O)OC(C)CCCC(=O)CCCC=C2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008510_numbered.png,2026-03-19 06:56:24.341969
3620,ML00010460,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3ccc(C(C)(C)C)cc3)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010460_numbered.png,2026-03-19 06:56:24.368538
3621,ML00010994,,,COc1ccc(CCNC(=O)COc2cc3c(c(OC)c2)C(=O)OC(C)CCCC(=O)CCCCC3)cc1OC,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010994_numbered.png,2026-03-19 06:56:24.394067
3622,ML00003558,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2cccs2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003558_numbered.png,2026-03-19 06:56:24.455293
3623,ML00008523,,,COc1cc(O)c2c(c1C)C(=O)OCCCCC(=S)N[C@H](c1nc(CO)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3624,ML00007732,,,C[C@@H]1C[C@@H]2O[C@@H]2C[C@H](O)/C=C\C(O)=C/c2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 8, 11]",ring_size_14/standard/numbered/ML00007732_numbered.png,2026-03-19 06:56:24.491631
3625,ML00009571,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@](C)(F)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,14.0,"[3, 4, 4, 5, 6, 7, 8, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009571_numbered.png,2026-03-19 06:56:24.560684
3626,ML00003613,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(N)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003613_numbered.png,2026-03-19 06:56:24.625463
3627,ML00000240,CHEMBL315575,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)N2CCN(C)CC2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000240_numbered.png,2026-03-19 06:56:24.651855
3628,ML00001483,CHEMBL408925,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(CC3CC3)CC3CC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001483_numbered.png,2026-03-19 06:56:24.711260
3629,ML00002204,,,CC(=O)OC[C@@]12[C@@H](OC(C)=O)[C@@H](OC(=O)c3cccnc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3630,ML00002878,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3631,ML00006782,,,C[C@@H]1C/C=C/CC/C=C/C(=N/OCC(=O)N2CCCCC2)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00006782_numbered.png,2026-03-19 06:56:24.751902
3632,ML00001273,CHEMBL583298,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4c(O)cnc5ncccc45)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001273_numbered.png,2026-03-19 06:56:24.807790
3633,ML00006874,,,COc1cc2c(c(OC)c1)C(=O)O[C@@H](C)CCC[C@@H](O)[C@@H](C)CC/C=C/2,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00006874_numbered.png,2026-03-19 06:56:24.836423
3634,ML00007150,,,CO[C@H]1/C=C\CC/C=C\C(=O)O[C@H]([C@H](C)C(=O)CCCC2CC(=O)NC(=O)C2)/C(C)=C\[C@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 6, 7, 8]",ring_size_14/standard/numbered/ML00007150_numbered.png,2026-03-19 06:56:24.871130
3635,ML00011007,,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3O[C@@](O)(C2)[C@@H](C)C(=O)O[C@@H](/C=C/C=C/Br)C[C@@H](C)C/C=C\[C@H](O)[C@@H]3C)[C@H](OC)[C@@H]1OC,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3636,ML00007820,,,O=C1CCc2ccc(O)c(c2)Oc2cccc(c2)[C@H]2O[C@H]2CO1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3637,ML00004477,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](OC(=O)Cc3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004477_numbered.png,2026-03-19 06:56:24.948822
3638,ML00008531,,,COc1cc(OC)c2c(c1Cl)/C=C/CCCC(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008531_numbered.png,2026-03-19 06:56:24.973532
3639,ML00004233,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@H]2N(NCCCc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004233_numbered.png,2026-03-19 06:56:25.025320
3640,ML00008442,,,C/C1=C/C(=O)O[C@@H](C[C@H](O)[C@@H]2CSC(=O)N2)C[C@H](O)CC[C@H](C)/C=C\CC1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 8, 13]",ring_size_14/standard/numbered/ML00008442_numbered.png,2026-03-19 06:56:25.056965
3641,ML00005973,,,CC(=O)O[C@H]1[C@H](OC(C)=O)[C@@H]2[C@@H](OC(=O)c3ccccc3)[C@@]34O[C@]2(C)COC(=O)c2cccnc2[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@H](OC(=O)c2ccccc2)[C@@]13OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3642,ML00002905,,,CCC(=O)OCCC(=O)OC1C(OC2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)C(C)(O)C(O)C(C)C(=O)C(C)CC2(C)O)OC(C)CC1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002905_numbered.png,2026-03-19 06:56:25.127490
3643,ML00009786,,,CC[C@@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@H](OC)[C@@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@@]2(CO2)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009786_numbered.png,2026-03-19 06:56:25.192897
3644,ML00009631,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OS(=O)(=O)Cc2ccccc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)C2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009631_numbered.png,2026-03-19 06:56:25.259204
3645,ML00009452,,,CCCCNC(=O)CO[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009452_numbered.png,2026-03-19 06:56:25.329051
3646,ML00003648,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@H](C)C(=O)O[C@H]([C@@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3647,ML00005994,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3cccnc3)[C@@H]3[C@@H](OC(=O)c4ccco4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3648,ML00006479,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3649,ML00004322,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NC/C=C/c3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004322_numbered.png,2026-03-19 06:56:25.406586
3650,ML00007706,,,C[C@H]1C/C=C\[C@H](O)C/C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 11]",ring_size_14/standard/numbered/ML00007706_numbered.png,2026-03-19 06:56:25.434956
3651,ML00005619,,,C=C[C@]12OC(=O)N(CCCCn3cnc(-c4ccc(OC)nc4)c3C)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005619_numbered.png,2026-03-19 06:56:25.491763
3652,ML00005976,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005976_numbered.png,2026-03-19 06:56:25.556264
3653,ML00005864,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CC(C)(C)C[C@@H]2c2ccc(Cl)cc2Cl)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005864_numbered.png,2026-03-19 06:56:25.616156
3654,ML00006459,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3655,ML00005919,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#CCc2ccc(-c3cccnc3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005919_numbered.png,2026-03-19 06:56:25.680172
3656,ML00005920,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ccccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00005920_numbered.png,2026-03-19 06:56:25.740101
3657,ML00005977,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NCC2CC=CCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005977_numbered.png,2026-03-19 06:56:25.803902
3658,ML00003858,,,CCCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003858_numbered.png,2026-03-19 06:56:25.867850
3659,ML00003298,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc([N+](=O)[O-])cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003298_numbered.png,2026-03-19 06:56:25.921813
3660,ML00010510,,,COc1cccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)c1OCC(C)C,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010510_numbered.png,2026-03-19 06:56:25.947149
3661,ML00005896,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2C(NC(=O)CCc3ccc4ccccc4c3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005896_numbered.png,2026-03-19 06:56:26.002822
3662,ML00001858,CHEMBL1096740,,C[C@@H]1OC(=O)c2c(O)cc(N(C)C)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001858_numbered.png,2026-03-19 06:56:26.037310
3663,ML00002414,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCC#Cc3cncnc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002414_numbered.png,2026-03-19 06:56:26.095342
3664,ML00003263,,,CC[C@H]1OC(=O)[C@H](C)C(=O)C[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccccc3c2)CCC(=O)C[C@H]2NC(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,8.0,"[3, 4, 7, 10, 10, 11, 13, 14]",ring_size_14/standard/numbered/ML00003263_numbered.png,2026-03-19 06:56:26.145631
3665,ML00002785,,,CC[C@H]1OC(=O)C(C)(Cl)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002785_numbered.png,2026-03-19 06:56:26.208020
3666,ML00001968,CHEMBL60729,,O=C(NC(Cc1ccccc1)C(O)CN1CCCCCCCCCCC(c2ccccc2)OC1=O)O[C@H]1CO[C@H]2OCC[C@@H]12,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3667,ML00001605,CHEMBL1269437,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCNC(C)=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001605_numbered.png,2026-03-19 06:56:26.279609
3668,ML00000950,CHEMBL273466,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCOC2=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000950_numbered.png,2026-03-19 06:56:26.339419
3669,ML00001694,CHEMBL1097785,,CC(=O)NCC(=O)COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001694_numbered.png,2026-03-19 06:56:26.373987
3670,ML00007900,,,C[C@@H]1CCCCCCCC(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007900_numbered.png,2026-03-19 06:56:26.398215
3671,ML00003862,,,CCCO[C@@]1(C)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003862_numbered.png,2026-03-19 06:56:26.462586
3672,ML00004711,,,CCCC(=O)O[C@H]1[C@H](C)OC(O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc3ccccc3)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004711_numbered.png,2026-03-19 06:56:26.528441
3673,ML00000009,CHEMBL532,ERYTHROMYCIN,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000009_numbered.png,2026-03-19 06:56:26.592925
3674,ML00002394,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cccc(C3OCCO3)c2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002394_numbered.png,2026-03-19 06:56:26.656754
3675,ML00007906,,,C[C@H]1CCC[C@@H](O)CC/C=C\Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007906_numbered.png,2026-03-19 06:56:26.681896
3676,ML00001741,CHEMBL1099196,,C[C@@H]1OC(=O)c2c(O)cc(OCc3ccc(Cl)c(Cl)c3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001741_numbered.png,2026-03-19 06:56:26.716191
3677,ML00006167,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N(CC)CC)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3cccnn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006167_numbered.png,2026-03-19 06:56:26.775486
3678,ML00005718,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC/C(=N\Oc3ccccc3-c3ccccc3)CCO[C@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]3NC(=O)O[C@]13C)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00005718_numbered.png,2026-03-19 06:56:26.826827
3679,ML00003220,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2ccnc3ccccc23)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003220_numbered.png,2026-03-19 06:56:26.884936
3680,ML00001528,CHEMBL373669,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCNC(=O)CCC3=CC4=Cc5c(C)cc(C)n5[B-](F)(F)[N+]4=C3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001528_numbered.png,2026-03-19 06:56:26.951476
3681,ML00001820,CHEMBL3891314,,C[C@H]1CCC/C=C/[C@H](O)/C=C\[C@H](O)/C=C/C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 9, 12]",ring_size_14/standard/numbered/ML00001820_numbered.png,2026-03-19 06:56:26.979687
3682,ML00009520,,,CC[C@H]1OC(=O)[C@@H]2CO[C@]3(C[C@@](C)(OC)[C@H](O)[C@@H](C)O3)O[C@H]2[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12]",ring_size_14/standard/numbered/ML00009520_numbered.png,2026-03-19 06:56:27.036170
3683,ML00004744,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccc3c(c2)OCO3)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCSc3nc4ccc(OC)nc4[nH]3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004744_numbered.png,2026-03-19 06:56:27.095621
3684,ML00001566,CHEMBL1269449,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCc2cc(C)on2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001566_numbered.png,2026-03-19 06:56:27.160285
3685,ML00002777,,,C=C[C@]12OC(=O)N(CCCCn3ccc4ncccc43)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002777_numbered.png,2026-03-19 06:56:27.216471
3686,ML00010818,,,CC(C)COc1ccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010818_numbered.png,2026-03-19 06:56:27.241650
3687,ML00001396,CHEMBL2204327,,O=C1CCC[C@H](CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)N[C@@H]2CN3CCC2CC3)CO1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3688,ML00009809,,,C=C1NC(=O)C(C)C(CCC(C)C(=O)/C=C/C(C)=C/CC(C)CCCCCCC)OC(=O)[C@H](CC(OS(=O)(=O)O)C(N)=O)NC(=O)[C@@H](C)CNC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3689,ML00002169,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CNC(=O)NCc3cnc4ccccc4n3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002169_numbered.png,2026-03-19 06:56:27.310141
3690,ML00006609,,,CC[C@H](C)[C@]1(O)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](O)(C(C)C)[C@@H](C)OC(=O)[C@H]1O)[C@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3691,ML00010250,,,COc1ccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)c(OC)c1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010250_numbered.png,2026-03-19 06:56:27.342634
3692,ML00006662,,,COc1cc(O)c2c(c1Br)C(=O)OCCN(C(=O)C(C)(C)C)CC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3693,ML00009210,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CC#N)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)C2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009210_numbered.png,2026-03-19 06:56:27.411024
3694,ML00009742,,,CO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@H](C)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009742_numbered.png,2026-03-19 06:56:27.469452
3695,ML00010768,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C(C)=O)[C@@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010768_numbered.png,2026-03-19 06:56:27.530711
3696,ML00006577,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccccc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006577_numbered.png,2026-03-19 06:56:27.596001
3697,ML00006571,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccc(O)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006571_numbered.png,2026-03-19 06:56:27.668116
3698,ML00001411,CHEMBL1774286,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001411_numbered.png,2026-03-19 06:56:27.735062
3699,ML00001891,CHEMBL549289,,CC(=O)S[C@@H]1/C=C\CC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O[C@H](C)C[C@H]2O[C@@H]21,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 11]",ring_size_14/standard/numbered/ML00001891_numbered.png,2026-03-19 06:56:27.765075
3700,ML00002319,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCCc2ccc(OC)c(OC)c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002319_numbered.png,2026-03-19 06:56:27.829663
3701,ML00003974,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3702,ML00002860,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)C(C)C)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1cccnc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3703,ML00001659,CHEMBL288396,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](NC)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001659_numbered.png,2026-03-19 06:56:27.903492
3704,ML00005943,,,C=C[C@]12OC(=O)N(CCCCn3cnc(-c4ccc(C)nc4)c3)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005943_numbered.png,2026-03-19 06:56:27.961123
3705,ML00003160,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCc1ccnc2ccccc12,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003160_numbered.png,2026-03-19 06:56:28.014390
3706,ML00003767,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)c2cccc(OC)c2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003767_numbered.png,2026-03-19 06:56:28.078122
3707,ML00004704,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3ccc(-c4cn(CCCCC(=O)NO)nn4)cc3)C2O)C(C)(OC)CC(C)C(=O)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004704_numbered.png,2026-03-19 06:56:28.143645
3708,ML00010556,,,CC[C@H]1OC(=O)[C@H](C)C[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00010556_numbered.png,2026-03-19 06:56:28.196029
3709,ML00000035,CHEMBL4099337,,COc1cc(O)c2c(c1)CCC[C@H](O)[C@H](O)C(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00000035_numbered.png,2026-03-19 06:56:28.227518
3710,ML00010606,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1cc2cccc4c2n(c1=O)CC4)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010606_numbered.png,2026-03-19 06:56:28.252813
3711,ML00002818,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002818_numbered.png,2026-03-19 06:56:28.308360
3712,ML00004593,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCCCNc3ccc4c(=O)c(C(=O)O)cn(C)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004593_numbered.png,2026-03-19 06:56:28.373571
3713,ML00009202,,,C=C1CO[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(C[C@@H](C)/C(=N\O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)OC1,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 5, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00009202_numbered.png,2026-03-19 06:56:28.431683
3714,ML00003351,,,CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H]2[C@@H](O)[C@@]34O[C@@]2(C)COC(=O)c2cnccc2C(C)C(C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]13COC(=O)c1ccoc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3715,ML00007709,,,C[C@H]1C[C@H]2O[C@@H]2CC/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007709_numbered.png,2026-03-19 06:56:28.463987
3716,ML00005365,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](C)[C@@H](OCc4ccccc4)[C@H](N(C)C)[C@H]3OC(=O)c3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005365_numbered.png,2026-03-19 06:56:28.527003
3717,ML00008704,,,CCCCC[C@@H]1OC(=O)CCCCCCC/C=C\C[C@@H]1O,standard_macrolactone,14.0,,,success,,2.0,"[3, 4]",ring_size_14/standard/numbered/ML00008704_numbered.png,2026-03-19 06:56:28.551263
3718,ML00005423,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNCCCCCc2ccccc2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005423_numbered.png,2026-03-19 06:56:28.617440
3719,ML00008342,,,COc1cc(O)c2c(c1)CC(=O)CCCC/C=C\C[C@@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00008342_numbered.png,2026-03-19 06:56:28.642467
3720,ML00001805,CHEMBL560924,,CO/N=C1\C=C\C=C/[C@H]2O[C@@H]2C[C@@H](C)OC(=O)c2c(O)cc(O)c(Cl)c2C1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00001805_numbered.png,2026-03-19 06:56:28.667486
3721,ML00006890,,,Cc1nc(/C=C/[C@@H]2C/C=C\CCCC(C)C(=O)C(C)[C@@H](O)CC(=O)O2)cs1,standard_macrolactone,14.0,,,success,,5.0,"[3, 10, 11, 12, 13]",ring_size_14/standard/numbered/ML00006890_numbered.png,2026-03-19 06:56:28.701571
3722,ML00001086,CHEMBL3827713,,CC(=O)Oc1cc(O)c2c(c1)/C=C/CCC[C@@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00001086_numbered.png,2026-03-19 06:56:28.725832
3723,ML00003357,,,CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H]2[C@H](O)[C@@]34O[C@@]2(C)COC(=O)c2cnccc2[C@H](C)[C@](C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]13COC(=O)c1ccoc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3724,ML00006823,,,COc1cc(O)c2c(c1Br)C(=O)OCCN(C(=O)[C@@H](N)CC(C)C)CC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3725,ML00003987,,,CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H]2[C@@H](OC(C)=O)[C@@]34O[C@@]2(C)COC(=O)c2cnccc2[C@H](C)[C@](C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]13COC(=O)c1ccco1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3726,ML00009455,,,CC[C@H]1OC(=O)C[C@@H](O[C@H]2C[C@@](C)(OC)[C@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13]",ring_size_14/standard/numbered/ML00009455_numbered.png,2026-03-19 06:56:28.802998
3727,ML00009544,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009544_numbered.png,2026-03-19 06:56:28.863223
3728,ML00003742,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003742_numbered.png,2026-03-19 06:56:28.925764
3729,ML00001195,CHEMBL327710,,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCC(=O)NCCCOC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3730,ML00002480,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002480_numbered.png,2026-03-19 06:56:28.994866
3731,ML00005809,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC2CCCN(CCCc3ccccc3)C2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005809_numbered.png,2026-03-19 06:56:29.057648
3732,ML00003882,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCC(=O)NCc2ccc(OC)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003882_numbered.png,2026-03-19 06:56:29.120276
3733,ML00003946,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]3[C@H](OC(C)=O)[C@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@H]([C@@H](O)[C@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3734,ML00008084,,,C[C@@H]1CCC(=O)/C=C/C(=O)O[C@H](C)[C@@H](O)/C=C/C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3735,ML00008346,,,COc1cc(O)c2c(c1)C=CCCCC(=O)CCCC(C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008346_numbered.png,2026-03-19 06:56:29.156708
3736,ML00002468,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC/C(=N\OCc3ccccc3)CCO[C@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]3NC(=O)O[C@]13C)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00002468_numbered.png,2026-03-19 06:56:29.205523
3737,ML00004907,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)CN(CCCCc4ccccc4)C[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(C)=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3738,ML00004747,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc(-c5ccoc5)c4)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004747_numbered.png,2026-03-19 06:56:29.272991
3739,ML00001871,CHEMBL558508,RADICICOL DIACETATE,CC(=O)Oc1cc(OC(C)=O)c2c(c1Cl)CC(=O)/C=C/C=C\[C@H]1O[C@@H]1C[C@@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00001871_numbered.png,2026-03-19 06:56:29.299370
3740,ML00003427,,,C#CCN(C)C1CC(C)OC(OC2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)C(C)(O)C(O)C(C)C(=O)C(C)CC2(C)O)C1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003427_numbered.png,2026-03-19 06:56:29.361992
3741,ML00003235,,,CC(=O)OC[C@]12[C@H](OC(=O)C(C)C)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3742,ML00001813,CHEMBL1094233,,C[C@@H]1OC(=O)c2c(O)cc(O)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001813_numbered.png,2026-03-19 06:56:29.405422
3743,ML00006574,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006574_numbered.png,2026-03-19 06:56:29.472099
3744,ML00007550,,,C=C(CCCC(O)CC(C)O)C[C@H]1CC(=C)C[C@@H](O)C/C(C)=C/[C@H](O)CCCC(=O)O1,standard_macrolactone,14.0,,,success,,5.0,"[3, 5, 7, 9, 11]",ring_size_14/standard/numbered/ML00007550_numbered.png,2026-03-19 06:56:29.507809
3745,ML00002426,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4cccc5nc[nH]c45)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002426_numbered.png,2026-03-19 06:56:29.564732
3746,ML00007983,,,C[C@H]1CCCCCC/C=C\CCC(=O)OC1,standard_macrolactone,14.0,,,success,,1.0,[4],ring_size_14/standard/numbered/ML00007983_numbered.png,2026-03-19 06:56:29.587036
3747,ML00002823,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCCCc2cncc3ccccc23)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002823_numbered.png,2026-03-19 06:56:29.644767
3748,ML00003044,,,CO[C@H]1C[C@@H](C)O[C@@H](O[C@H]2[C@@H](C)C[C@](C)(O)C(=O)[C@H](C)[C@@H](OC(C)=O)[C@@H](C)[C@@H]([C@@H](C)[C@H](C)O)OC(=O)[C@H](C)[C@@H](O[C@H]3C[C@@](C)(OC)[C@H](OC(C)=O)[C@H](C)O3)[C@@H]2C)[C@@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003044_numbered.png,2026-03-19 06:56:29.710243
3749,ML00005913,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2cnc3c(OC)cccc3c2)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005913_numbered.png,2026-03-19 06:56:29.765981
3750,ML00002761,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccnc4ccccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00002761_numbered.png,2026-03-19 06:56:29.820845
3751,ML00007727,,,C[C@@H]1C[C@H]2O[C@@H]2C=CCC=C(N=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007727_numbered.png,2026-03-19 06:56:29.847003
3752,ML00000934,CHEMBL275521,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCOC2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000934_numbered.png,2026-03-19 06:56:29.908027
3753,ML00008387,,,COc1cc(O)c2c(c1)[C@H]1O[C@@H]1C[C@H](O)[C@H](O)C(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008387_numbered.png,2026-03-19 06:56:29.942016
3754,ML00002512,,,CC(=O)OC1C2C(OC(C)=O)C34OC2(C)COC(=O)c2cccnc2C(C)C(C)(O)C(=O)OC(C(OC(C)=O)C(OC(C)=O)C3(COC(=O)c2ccoc2)C1OC(C)=O)C4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3755,ML00001715,CHEMBL3931700,,COCCNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001715_numbered.png,2026-03-19 06:56:29.984440
3756,ML00001843,CHEMBL2012384,,C[C@H]1C/C=C/CCCC/C=C/c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00001843_numbered.png,2026-03-19 06:56:30.006171
3757,ML00007925,,,C[C@@H]1C[C@@H](O)/C=C\[C@H](O)CCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 8, 11]",ring_size_14/standard/numbered/ML00007925_numbered.png,2026-03-19 06:56:30.037173
3758,ML00003709,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H]([C@@H](C)SC)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003709_numbered.png,2026-03-19 06:56:30.098682
3759,ML00006050,,,CO[C@H]1[C@H](OC[C@H](C)[C@H]2OC(=O)[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)CC(=O)[C@H]3O)[C@@H](C)C[C@](C)(O)C(=O)[C@H](C)[C@@H](OC(=O)[C@H](O)C(C)C)[C@H]2C)O[C@H](C)[C@@H](O)[C@H]1OC,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006050_numbered.png,2026-03-19 06:56:30.163885
3760,ML00009504,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCCNCCN(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009504_numbered.png,2026-03-19 06:56:30.226568
3761,ML00002794,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)/C=C/c2ccc(C)cc2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002794_numbered.png,2026-03-19 06:56:30.289313
3762,ML00003537,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](O)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(Br)nc2)C[C@@H](C)C(=O)[C@H](C)[C@@H]2NC(=S)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003537_numbered.png,2026-03-19 06:56:30.346394
3763,ML00006468,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H]2[C@H](C)[C@@H](OCN2C(C)CCCN(CC)CC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006468_numbered.png,2026-03-19 06:56:30.404345
3764,ML00008343,,,COc1cc(O)c2c(c1)CC(=O)CCCC/C=C/C[C@@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00008343_numbered.png,2026-03-19 06:56:30.434646
3765,ML00008959,,,C#CCNCCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00008959_numbered.png,2026-03-19 06:56:30.498090
3766,ML00005499,,,CCCCCCC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005499_numbered.png,2026-03-19 06:56:30.562082
3767,ML00010243,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1ccccc1OCC(=O)O)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010243_numbered.png,2026-03-19 06:56:30.587615
3768,ML00005641,,,C=C[C@]12OC(=O)N(CCN(C)Cc3ccnc(-c4cccnc4)c3)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005641_numbered.png,2026-03-19 06:56:30.644793
3769,ML00008688,,,COc1cc(O)c2c(c1)CC(=O)/C=C/C=C\[C@H]1O[C@@H]1C[C@@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00008688_numbered.png,2026-03-19 06:56:30.670770
3770,ML00003712,,,CC[C@@H]1OC(=O)[C@@H](C)[C@H](O[C@@H]2C[C@](C)(OC)[C@H](O)[C@@H](C)O2)C(C)[C@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@](C)(OC)C[C@H](C)C(=O)[C@@H](C)[C@H](O)[C@@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003712_numbered.png,2026-03-19 06:56:30.734847
3771,ML00002156,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NCc2ccc3ncccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2CC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002156_numbered.png,2026-03-19 06:56:30.793082
3772,ML00005498,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H]2[C@H](C)[C@@H](OCN2Cc2ccccc2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005498_numbered.png,2026-03-19 06:56:30.850571
3773,ML00004123,,,C=CCO[C@@H]1C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccc(F)c2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004123_numbered.png,2026-03-19 06:56:30.907424
3774,ML00006675,,,C[C@@H]1C[C@@H]2O[C@H]2/C=C\C=C/C(=O)Cc2c(Cl)c(O[C@H]3O[C@H](CO)[C@@H](O)[C@@H]3O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00006675_numbered.png,2026-03-19 06:56:30.933681
3775,ML00010811,,,COc1cc(C2CC(=O)Oc3cc4c(c(OC)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc(OC)c1OC,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010811_numbered.png,2026-03-19 06:56:30.959706
3776,ML00007973,,,C[C@@H]1C[C@H]2O[C@H]2CCCCC(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007973_numbered.png,2026-03-19 06:56:30.985366
3777,ML00004879,,,CC[C@H]1OC(=O)[C@H](C)C(OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCc3ccnc4ccccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004879_numbered.png,2026-03-19 06:56:31.045439
3778,ML00003698,,,CC[C@H]1OC(=O)[C@H](C)[C@H](OC(=O)c2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003698_numbered.png,2026-03-19 06:56:31.109277
3779,ML00006821,,,C[C@@H]1C(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)O[C@H](C)CC[C@@H](C)C1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3780,ML00001731,CHEMBL1435425,,CO[C@H]1C[C@@H]2C[C@H](O)C[C@@H](CC(=O)O[C@@H](/C=C\CC(C)C)C[C@@H]3CC[C@H](C)[C@@H](C1)O3)O2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3781,ML00001269,CHEMBL1688546,KOSAN-1325,C[C@@H]1C[C@H](N(C)C)C(O)[C@H](O[C@@H]2[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@H](CCNC(=O)Cc3cccc(-c4ccco4)c3)[C@@]3(C)OC(=O)N[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)O1,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001269_numbered.png,2026-03-19 06:56:31.180280
3782,ML00005722,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cccnc2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005722_numbered.png,2026-03-19 06:56:31.241673
3783,ML00006568,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCCCOCCCNC(=O)Cc2ccc(OC)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006568_numbered.png,2026-03-19 06:56:31.300150
3784,ML00008558,,,C[C@H]1CCCCCCCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008558_numbered.png,2026-03-19 06:56:31.323300
3785,ML00009794,,,C=COCCCN1C(=O)O[C@]2(C)[C@@H](CC)OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]12,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00009794_numbered.png,2026-03-19 06:56:31.379872
3786,ML00005639,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccc(N)nc2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005639_numbered.png,2026-03-19 06:56:31.440320
3787,ML00006339,,,CC(=O)O[C@@H]1[C@H](OC(=O)c2ccccc2)[C@@]2(OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]24O[C@]3(C)COC(=O)c2cccnc2[C@@H](C)[C@H](C)C(=O)O[C@@H]1[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3788,ML00005929,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)c2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005929_numbered.png,2026-03-19 06:56:31.519951
3789,ML00009222,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CNC3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009222_numbered.png,2026-03-19 06:56:31.576299
3790,ML00003030,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3791,ML00003604,,,CC(=O)O[C@@H]1[C@@H](O)[C@]2(OC(C)=O)[C@@H](O)[C@@H](OC(=O)C3=CN(C)C(=O)CC3)[C@@H]3OC(=O)[C@@H](C)[C@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@]2([C@H](OC(C)=O)[C@@H]14)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3792,ML00006905,,,C=C1/C=C(\C)[C@H](CC)OC(=O)[C@H](C)C(=O)[C@@](O)(CO)C/C(C)=C/[C@@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00006905_numbered.png,2026-03-19 06:56:31.638674
3793,ML00001569,CHEMBL574848,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001569_numbered.png,2026-03-19 06:56:31.703318
3794,ML00007758,,,C[C@H]1C/C=C/CC/C=C/C(=O)Cc2cccc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007758_numbered.png,2026-03-19 06:56:31.729006
3795,ML00003124,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003124_numbered.png,2026-03-19 06:56:31.785938
3796,ML00000667,CHEMBL82435,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)NCCO)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000667_numbered.png,2026-03-19 06:56:31.811524
3797,ML00004845,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)(CN(C)Cc3ccc(-c4cn(CCC(=O)NO)nn4)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(OC)CC(C)C(=O)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004845_numbered.png,2026-03-19 06:56:31.875759
3798,ML00007453,,,O=C1CC=C(C2=C(O)C(=O)O[C@]23Cc2ccc(cc2)Oc2cc(cc(O)c2O)CCOC3=O)C=CO1,non_standard_macrocycle,14.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
3799,ML00001068,CHEMBL3827116,,CC(=O)Oc1cc2c(c(OC(C)=O)c1)C(=O)O[C@@H](C)CCCC(=O)CCC/C=C/2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00001068_numbered.png,2026-03-19 06:56:31.906972
3800,ML00000754,CHEMBL449844,,COc1ccc2c(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)NS(=O)(=O)C6CC6)C[C@H]5/C=C\CCCCOC(=O)N4C3)cc(-c3ccccc3)nc2c1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3801,ML00007945,,,C[C@H]1C/C=C\[C@@H](O)[C@@H](O)CC[C@H]2O[C@@H]2c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00007945_numbered.png,2026-03-19 06:56:31.941179
3802,ML00005233,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCCCCOCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005233_numbered.png,2026-03-19 06:56:32.007702
3803,ML00010958,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@](C)(O)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010958_numbered.png,2026-03-19 06:56:32.067667
3804,ML00007710,,,C[C@H]1C[C@H]2O[C@@H]2CC/C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007710_numbered.png,2026-03-19 06:56:32.093419
3805,ML00007703,,,C[C@H]1C/C=C\CC/C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007703_numbered.png,2026-03-19 06:56:32.118012
3806,ML00009707,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3807,ML00009595,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](OC(=O)NCCCl)[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OC(=O)NCCCl)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009595_numbered.png,2026-03-19 06:56:32.182170
3808,ML00008325,,,COc1cc(O)c2c(c1)/C=C\C[C@H](O)[C@H](O)[C@@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008325_numbered.png,2026-03-19 06:56:32.213691
3809,ML00008504,,,COc1cc(O)c2c(c1OC)/C=C\C[C@@H](O)[C@H](O)C(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008504_numbered.png,2026-03-19 06:56:32.245801
3810,ML00007965,,,C[C@H]1CCCC(=O)[C@H](O)CC/C=C\c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00007965_numbered.png,2026-03-19 06:56:32.273977
3811,ML00008793,,,CO[C@H]1/C=C\[C@@](C)(O)CCC(=O)O[C@H](C)[C@@H](C)CC/C=C\1C,standard_macrolactone,14.0,,,success,,6.0,"[3, 4, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00008793_numbered.png,2026-03-19 06:56:32.310880
3812,ML00006102,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(C(F)(F)F)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006102_numbered.png,2026-03-19 06:56:32.381210
3813,ML00001613,CHEMBL582873,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001613_numbered.png,2026-03-19 06:56:32.447516
3814,ML00002800,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCCCc3ccccc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002800_numbered.png,2026-03-19 06:56:32.504832
3815,ML00000355,CHEMBL488624,,CO[C@H]1/C=C/CC/C=C/C(=O)O[C@H]([C@H](C)C(=O)C[C@H](O)CC2CC(=O)NC(=O)C2)/C(C)=C\[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 6, 7, 8]",ring_size_14/standard/numbered/ML00000355_numbered.png,2026-03-19 06:56:32.541008
3816,ML00009687,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@](C)(O)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3817,ML00007816,,,C[C@H]1C[C@@H]2O[C@@H]2/C=C\C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007816_numbered.png,2026-03-19 06:56:32.572941
3818,ML00008740,,,COCc1noc([C@@H]2CSCc3c(O)cc(OC)c(Br)c3C(=O)OCC(=O)NCC(=O)N2)n1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3819,ML00010255,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1ccc2c(c1)OCCO2)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010255_numbered.png,2026-03-19 06:56:32.603454
3820,ML00002176,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)/C=C/c2ccc(Cl)cc2Cl)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002176_numbered.png,2026-03-19 06:56:32.664852
3821,ML00007730,,,C[C@H]1C[C@H](O)C(Cl)/C=C\C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 6, 11]",ring_size_14/standard/numbered/ML00007730_numbered.png,2026-03-19 06:56:32.695902
3822,ML00005270,,,CCCCCCCCCCC(=O)O[C@H]1[C@H](C)OC(O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc3ccccc3)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005270_numbered.png,2026-03-19 06:56:32.760493
3823,ML00010959,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2OC(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010959_numbered.png,2026-03-19 06:56:32.815962
3824,ML00004915,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)C(=NC(C)=O)[C@H](C)C(OC/C(=N/OCc3cc(-c4ccccc4[N+](=O)[O-])no3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004915_numbered.png,2026-03-19 06:56:32.873266
3825,ML00010779,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010779_numbered.png,2026-03-19 06:56:32.934654
3826,ML00004832,,,CC[C@H]1OC(=O)/C(C)=C(/OCOCCCc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004832_numbered.png,2026-03-19 06:56:32.991145
3827,ML00003877,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCC(=O)NCCc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003877_numbered.png,2026-03-19 06:56:33.053540
3828,ML00008389,,,COc1cc(O)c2c(c1)[C@H]1O[C@@H]1C[C@H](O)[C@H](O)[C@H](O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008389_numbered.png,2026-03-19 06:56:33.084750
3829,ML00006997,,,COc1cc(O)c2c(c1Br)C(=O)OCC(=O)NCC(=S)N[C@H](c1nc(CNC(C)C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3830,ML00007063,,,CC(C)[C@@]1(O)CC(=O)O[C@@H](C)[C@](O)(C(C)C)C(=O)OCC2=CCN3CC[C@H](OC1=O)[C@@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3831,ML00007728,,,C[C@H]1C[C@H](O)[C@@H](Cl)/C=C\C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 6, 11]",ring_size_14/standard/numbered/ML00007728_numbered.png,2026-03-19 06:56:33.127228
3832,ML00007818,,,C[C@H]1C[C@@H]2O[C@H]2/C=C\C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007818_numbered.png,2026-03-19 06:56:33.151780
3833,ML00001878,CHEMBL2012394,,COc1cc(O)c2c(c1)/C=C/CC[C@H](O)[C@H](O)/C=C/C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00001878_numbered.png,2026-03-19 06:56:33.178706
3834,ML00002885,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2cncc3ccccc23)C[C@@H](C)C(=O)[C@H](C)[C@H]2CC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002885_numbered.png,2026-03-19 06:56:33.235708
3835,ML00006723,,,CCC(=O)Oc1cc2c(c(OC(=O)CC)c1)C(=O)O[C@@H](C)CCCC(=O)CCC/C=C/2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00006723_numbered.png,2026-03-19 06:56:33.260869
3836,ML00009648,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](O)[C@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3837,ML00006457,,,CC(=O)OCC12C(OC(C)=O)C(OC(C)=O)C3C(OC(=O)c4ccccc4)C14OC3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)OC(C(OC(C)=O)C2OC(=O)c1ccccc1)C4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3838,ML00000640,CHEMBL1397216,,CC1CCCC(=O)CCC/C=C/c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00000640_numbered.png,2026-03-19 06:56:33.298389
3839,ML00004330,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccc([N+](=O)[O-])c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CC3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004330_numbered.png,2026-03-19 06:56:33.362662
3840,ML00008094,,,C[C@H]1C[C@@H](O)C(=O)/C=C\C(=O)O[C@H](C)C/C=C\C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3841,ML00002866,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002866_numbered.png,2026-03-19 06:56:33.422743
3842,ML00003020,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3843,ML00009709,,,CC(=O)OCC12C(OC(C)=O)C(O)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)OC(C(OC(C)=O)C2OC(C)=O)C4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3844,ML00009713,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3845,ML00008528,,,COc1cc(OC)c2c(c1Cl)C[C@@H](O)/C=C/CC[C@H]1O[C@@H]1C[C@@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00008528_numbered.png,2026-03-19 06:56:33.468821
3846,ML00005309,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@](C)(OC)[C@H]2OC(=O)CCOCCOCCCc2ccc3c(c2)c(=O)c(C(=O)O)cn3CC)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005309_numbered.png,2026-03-19 06:56:33.534170
3847,ML00006987,,,COc1cc(O)c2c(c1C)C(=O)O[C@H](CO)CCC/C(S)=N/[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3848,ML00006914,,,C=C1/C=C(\C)[C@H](CC)OC(=O)[C@H](C)C(=O)[C@@](O)(CO)[C@@H](OC)/C=C/[C@@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 11, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00006914_numbered.png,2026-03-19 06:56:33.587648
3849,ML00000954,CHEMBL428008,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)C2CCCC2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000954_numbered.png,2026-03-19 06:56:33.645497
3850,ML00006138,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006138_numbered.png,2026-03-19 06:56:33.710336
3851,ML00006992,,,C[C@H]1C/C=C\[C@H]2OC(C)(C)O[C@H]2CC/C=C\c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00006992_numbered.png,2026-03-19 06:56:33.732110
3852,ML00006512,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3ccccc3)[C@H]3OC(=O)[C@@](C)(O)[C@H](C)c4ccncc4C(=O)OC[C@@]4(C)O[C@]1([C@H](OC(=O)c1ccccc1)[C@@H]4[C@@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3853,ML00004312,,,C#CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3cccc([N+](=O)[O-])c3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004312_numbered.png,2026-03-19 06:56:33.810703
3854,ML00002767,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cc(-c4cccc(N)c4)nn3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002767_numbered.png,2026-03-19 06:56:33.874894
3855,ML00003032,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3856,ML00005955,,,C=C[C@]12OC(=O)N(CCN(C)Cc3ccc(-c4cccnc4)s3)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005955_numbered.png,2026-03-19 06:56:33.940792
3857,ML00004467,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(-c5ccccc5OC)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004467_numbered.png,2026-03-19 06:56:34.008348
3858,ML00007846,,,C[C@H]1C/C=C/[C@@H](O)[C@@H](O)CCC(=NO)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 11]",ring_size_14/standard/numbered/ML00007846_numbered.png,2026-03-19 06:56:34.041661
3859,ML00006995,,,COc1cc(O)c2c(c1Br)C(=O)OCC(=O)NCC(=O)N[C@H](c1nc(CNC(C)C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3860,ML00005657,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccc(F)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005657_numbered.png,2026-03-19 06:56:34.112861
3861,ML00007990,,,C[C@@H]1C[C@H](O)CCCC/C=C\CCCC(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 5]",ring_size_14/standard/numbered/ML00007990_numbered.png,2026-03-19 06:56:34.137862
3862,ML00008397,,,COc1cc2c(c(OC)c1)C(=O)O[C@@H](C)CCC[C@H](O)CCC/C=C/2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008397_numbered.png,2026-03-19 06:56:34.162098
3863,ML00002782,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=C\C=C\c3ccccc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002782_numbered.png,2026-03-19 06:56:34.218414
3864,ML00006456,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3ccccc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3865,ML00009312,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(=O)[C@H](C)[C@@H](C)c4ncccc4C(=O)OC[C@@]4(C)O[C@@]1([C@@H](O)[C@H]4C(=O)[C@@H]2OC(C)=O)[C@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3866,ML00003216,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](O)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3cccnn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@@H]2NC(=S)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003216_numbered.png,2026-03-19 06:56:34.291222
3867,ML00004617,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3cc4c(=O)c(C(=O)OC)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004617_numbered.png,2026-03-19 06:56:34.358376
3868,ML00005918,,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)N/C=C/c2ccc(-c3ccccc3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005918_numbered.png,2026-03-19 06:56:34.417088
3869,ML00003173,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CNC(=O)OCc3ccnc4ccccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003173_numbered.png,2026-03-19 06:56:34.473963
3870,ML00002143,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(N)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002143_numbered.png,2026-03-19 06:56:34.533126
3871,ML00007103,,,C=C1/C=C(/C)[C@@H](CC)OC(=O)[C@@H](C)C(=O)[C@](O)(CO)C/C(OC)=C\[C@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00007103_numbered.png,2026-03-19 06:56:34.581840
3872,ML00007135,,,CC[C@H]1OC(=O)[C@H](OC)[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00007135_numbered.png,2026-03-19 06:56:34.636034
3873,ML00007920,,,C[C@H]1C/C=C\[C@@H](O)CCC/C=C\c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007920_numbered.png,2026-03-19 06:56:34.660931
3874,ML00006132,,,CC[C@H]1OC(=O)/C(C)=C(/OCOCCN(C)C)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006132_numbered.png,2026-03-19 06:56:34.717383
3875,ML00001064,CHEMBL3928290,,C[C@H]1CCC/C=C\[C@H](O)/C=C\[C@H](O)/C=C/C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 9, 12]",ring_size_14/standard/numbered/ML00001064_numbered.png,2026-03-19 06:56:34.745567
3876,ML00002831,,,C=C[C@@H]1[C@@H]2[C@@H]([C@@H]2/C=C/C=C/C=C/CCC)[C@@H]2C(=O)OC[C@]3(C)[C@H]4[C@@H]5C=C(CO)C[C@]6(O)C(=O)C(C)=C[C@H]6[C@@]5(O)[C@H](C)C[C@]43OC(=O)C/C=C\C=C[C@H]12,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3877,ML00007492,,,COc1cc2c(c(OCC(O)CNC(C)C)c1)C(=O)O[C@@H](C)CCCC(=O)CCC/C=C/2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007492_numbered.png,2026-03-19 06:56:34.782935
3878,ML00004306,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCOc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004306_numbered.png,2026-03-19 06:56:34.836815
3879,ML00000098,CHEMBL1200688,ERYTHROMYCIN ETHYLSUCCINATE,CCOC(=O)CCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000098_numbered.png,2026-03-19 06:56:34.902225
3880,ML00006614,,,CC[C@@](C)(O)[C@]1(O)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](O)(C(C)C)[C@@H](C)OC(=O)[C@H]1O)[C@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3881,ML00005836,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N/C(C)=O)[C@H](C)[C@@H](OC/C(=N/OCc3ccc(-c4cccc(N)n4)s3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005836_numbered.png,2026-03-19 06:56:34.970554
3882,ML00005732,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC/C(=N\Oc3cccc(-c4ccccc4)c3)CCO[C@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]3NC(=O)O[C@]13C)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00005732_numbered.png,2026-03-19 06:56:35.022576
3883,ML00002418,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=C\c3ccccc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002418_numbered.png,2026-03-19 06:56:35.080870
3884,ML00004504,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNCc2ccccc2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004504_numbered.png,2026-03-19 06:56:35.148145
3885,ML00003448,,,C=CC(C)C(=O)NCCNC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003448_numbered.png,2026-03-19 06:56:35.208484
3886,ML00003883,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCCc2ccc(O)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003883_numbered.png,2026-03-19 06:56:35.274718
3887,ML00005910,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2CC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005910_numbered.png,2026-03-19 06:56:35.332833
3888,ML00003551,,,CC(=O)O[C@H]1[C@@H](OC(=O)C(C)(C)OC(C)=O)[C@]2(CO)[C@@H](OC(C)=O)[C@@H](O)[C@@H]3OC(=O)[C@@H](C)[C@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@@]2([C@H](OC(C)=O)[C@@H]14)[C@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3889,ML00000114,CHEMBL1668413,,COc1cc(O)c2c(c1)CCCCCC(=O)C[C@H](Cl)C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 5, 7]",ring_size_14/standard/numbered/ML00000114_numbered.png,2026-03-19 06:56:35.368966
3890,ML00006229,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc5ccncc54)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006229_numbered.png,2026-03-19 06:56:35.427468
3891,ML00008003,,,C[C@H]1C[C@@H](O)C(=O)C[C@@H](O)C(=O)O[C@H](C)C/C=C\C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3892,ML00004444,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]3OC(=O)c3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004444_numbered.png,2026-03-19 06:56:35.502561
3893,ML00000160,CHEMBL1436532,,C[C@H]1COC(=O)C/C=C\[C@@H](C)COC(=O)[C@H](Cc2ccccc2)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3894,ML00006181,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC/C=C/c2cncc3ccccc23)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2Cl)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006181_numbered.png,2026-03-19 06:56:35.578146
3895,ML00007668,,,Cc1nc(CC(C)C(O)C[C@H]2OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC[C@H]2O)cs1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 8, 9, 10, 11, 12, 12, 13]",ring_size_14/standard/numbered/ML00007668_numbered.png,2026-03-19 06:56:35.627640
3896,ML00009008,,,CC/C=N/C(=O)CO[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009008_numbered.png,2026-03-19 06:56:35.691311
3897,ML00009311,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(=O)[C@@H](C)[C@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@]1([C@H](O)[C@@H]4C(=O)[C@@H]2OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3898,ML00009203,,,C=C1CO[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)OC1,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 5, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00009203_numbered.png,2026-03-19 06:56:35.756022
3899,ML00007346,,,COc1ccc(NC(=O)COc2cc(OC)cc3c2C(=O)OC(C)CCCC(=O)CCCCC3)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007346_numbered.png,2026-03-19 06:56:35.781296
3900,ML00002462,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccc2F)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002462_numbered.png,2026-03-19 06:56:35.844591
3901,ML00003768,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCCNCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003768_numbered.png,2026-03-19 06:56:35.908216
3902,ML00000107,CHEMBL1668415,,COc1cc(O)c2c(c1)CCCCCC(=O)C[C@H](Br)C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 5, 7]",ring_size_14/standard/numbered/ML00000107_numbered.png,2026-03-19 06:56:35.936697
3903,ML00002079,CHEMBL126046,,O=C1CCC[C@H](CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC(=O)[C@@H](NC(=O)OCc2ccccc2)CO1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3904,ML00006643,,,C/C=C/CNC(=N)NCCCCCCCCN1CCCCCOC(=O)CCNC(=N)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3905,ML00007498,,,COc1cc2c(c(OCC(O)CNC(C)C)c1)C(=O)O[C@@H](C)CCCC(=O)CCC/C=C/2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007498_numbered.png,2026-03-19 06:56:35.971858
3906,ML00002189,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NNCCc2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002189_numbered.png,2026-03-19 06:56:36.028757
3907,ML00004225,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccccc3O)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004225_numbered.png,2026-03-19 06:56:36.082787
3908,ML00004295,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC/C(=N\Oc3ccccc3)CCO[C@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]3NC(=O)O[C@]13C)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004295_numbered.png,2026-03-19 06:56:36.132941
3909,ML00008716,,,COc1cc(O)c2c(c1Br)C(=O)OCCN(C)CC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3910,ML00008000,,,C[C@H]1CCC/C=C\C/C=C\CCCC(=O)O1,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008000_numbered.png,2026-03-19 06:56:36.160203
3911,ML00004453,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]3OC(=O)c3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)/C(C)=C/[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004453_numbered.png,2026-03-19 06:56:36.225371
3912,ML00004298,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(C)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004298_numbered.png,2026-03-19 06:56:36.280116
3913,ML00001368,CHEMBL360361,,CC(C)C[C@H](NC(=O)[C@@H]1CC(=O)NC/C=C/COC(=O)N[C@@H](C(C)C)C(=O)N1)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3914,ML00002348,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cc(-c4ccccn4)nn3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002348_numbered.png,2026-03-19 06:56:36.344829
3915,ML00002235,,,CC(=O)OC[C@]12[C@H](O)[C@H](OC(=O)c3cccnc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)C(C)C)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3916,ML00007822,,,O=C1CCc2ccc(O)c(c2)Oc2cccc(c2)/C=C\CO1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3917,ML00004155,,,CC[C@H](C)[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004155_numbered.png,2026-03-19 06:56:36.418754
3918,ML00003798,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCOCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003798_numbered.png,2026-03-19 06:56:36.481422
3919,ML00002817,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCn1cnc(-c2ccc(OC)nc2)c1,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002817_numbered.png,2026-03-19 06:56:36.534672
3920,ML00002843,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3cccnn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002843_numbered.png,2026-03-19 06:56:36.594331
3921,ML00009308,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3922,ML00006002,,,CC(=O)O[C@@H]1[C@H](OC(=O)C(C)C)[C@@H]2[C@@H](O)[C@@]34O[C@@]2(C)COC(=O)c2cnccc2[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c2ccc(=O)n(C)c2)[C@H](OC(C)=O)[C@@]13COC(=O)C(C)C)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3923,ML00000246,CHEMBL82750,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)N2CCOCC2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000246_numbered.png,2026-03-19 06:56:36.635160
3924,ML00002519,,,C=CCO[C@@H]1C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccc3c(c2)OCO3)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002519_numbered.png,2026-03-19 06:56:36.690323
3925,ML00003945,,,CC(=O)OCC12C(OC(=O)c3ccccc3)C(O)C3OC(=O)C(C)C(C)c4ncccc4C(=O)OCC4(C)OC1(C(OC(C)=O)C4C(OC(C)=O)C2OC(C)=O)C3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3926,ML00008378,,,COc1cc(O)c2c(c1)/C=C/C[C@@H](O)[C@H](O)C(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008378_numbered.png,2026-03-19 06:56:36.728091
3927,ML00002425,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nnnn3-c3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002425_numbered.png,2026-03-19 06:56:36.783546
3928,ML00004297,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2C(NC(=O)CCc3cccnc3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004297_numbered.png,2026-03-19 06:56:36.839905
3929,ML00004468,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(-c5cccc(OC)c5)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004468_numbered.png,2026-03-19 06:56:36.906333
3930,ML00009028,,,C=CCOC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2OC(=O)N3C)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009028_numbered.png,2026-03-19 06:56:36.963676
3931,ML00009170,,,C=C1CO[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(C[C@@H](C)C(=N)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)OC1,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 5, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00009170_numbered.png,2026-03-19 06:56:37.020923
3932,ML00006359,,,CCC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006359_numbered.png,2026-03-19 06:56:37.079740
3933,ML00003245,,,CC(=O)O[C@H]1[C@H]2[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@]3(COC(=O)c4ccoc4)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]4OC(=O)[C@@](C)(O)[C@@H](C)c5ccncc5C(=O)OC[C@]2(C)O[C@]13[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3934,ML00009749,,,CCCNC(=O)CO[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009749_numbered.png,2026-03-19 06:56:37.150009
3935,ML00004184,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)[C@@H](N(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004184_numbered.png,2026-03-19 06:56:37.214701
3936,ML00003172,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NNCCc2cccc(-c3ncccn3)c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003172_numbered.png,2026-03-19 06:56:37.271743
3937,ML00010814,,,COc1ccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1OC(C)C,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010814_numbered.png,2026-03-19 06:56:37.297543
3938,ML00004256,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccc(N)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004256_numbered.png,2026-03-19 06:56:37.350063
3939,ML00008174,,,O=C1CCCC[C@H]2O[C@@H]2CCOC(=O)c2c(O)cc(O)c(Cl)c2C1,standard_macrolactone,14.0,,,success,,1.0,[11],ring_size_14/standard/numbered/ML00008174_numbered.png,2026-03-19 06:56:37.372387
3940,ML00010249,,,COc1ccc(C2CC(=O)Oc3cc4c(c(OC)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010249_numbered.png,2026-03-19 06:56:37.397688
3941,ML00007401,,,CCC1/C=C/[C@H](C(C)O)OC(=O)[C@@]2(C)C=CC(=O)NC3=C2C(=O)c2c(cc(C)c(O)c2C(=O)CC1)C3=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 6, 9, 12, 14]",ring_size_14/standard/numbered/ML00007401_numbered.png,2026-03-19 06:56:37.434047
3942,ML00008092,,,C[C@H]1CCC/C=C\CC/C=C\C=C/C(=O)O1,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008092_numbered.png,2026-03-19 06:56:37.455467
3943,ML00008727,,,C[C@H]1CCCC(=O)CCC/C=C\c2c(C=O)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008727_numbered.png,2026-03-19 06:56:37.479823
3944,ML00003805,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H]([C@H]3C[C@H](C)C3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003805_numbered.png,2026-03-19 06:56:37.540878
3945,ML00008322,,,COc1cc(O)cc2c1C(=O)OC(C)CCCC(O)CCCCC2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008322_numbered.png,2026-03-19 06:56:37.565802
3946,ML00002789,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=N\OCc3cc(-c4cccnc4)no3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002789_numbered.png,2026-03-19 06:56:37.622503
3947,ML00009221,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)C12C=NNC2C(=O)OC,standard_macrolactone,14.0,,,success,,11.0,"[3, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009221_numbered.png,2026-03-19 06:56:37.678932
3948,ML00003485,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCCNCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003485_numbered.png,2026-03-19 06:56:37.736418
3949,ML00002871,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NN(C)CCc2ccc(-c3ncccn3)cc2F)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002871_numbered.png,2026-03-19 06:56:37.794485
3950,ML00005398,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@@H]4COC(c5ccccc5)O[C@H]4[C@H](O)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc4cccnc43)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005398_numbered.png,2026-03-19 06:56:37.857596
3951,ML00007985,,,C[C@H]1CCCCCC/C=C\CCCC(=O)O1,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00007985_numbered.png,2026-03-19 06:56:37.879573
3952,ML00007961,,,C[C@@H]1C/C=C\CCCCC(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007961_numbered.png,2026-03-19 06:56:37.903122
3953,ML00002219,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3cccnc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1C(C)C(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3954,ML00000432,CHEMBL273275,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C3CCCC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000432_numbered.png,2026-03-19 06:56:37.969524
3955,ML00009357,,,CC(=O)OCC12C(OC(C)=O)C(O)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)OC(C(O)C2OC(C)=O)C4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3956,ML00004302,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](OC(=O)NCCc3ccccc3)[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\O)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004302_numbered.png,2026-03-19 06:56:38.032705
3957,ML00008514,,,COc1cc(O)c2c(c1C)C(=O)OCCCCC(=S)N[C@H](c1nc(CN)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3958,ML00003199,,,CC(=O)OC[C@@]12[C@@H](OC(C)=O)[C@H](OC(=O)c3ccccc3)[C@@H]3OC(=O)[C@@](C)(O)[C@@H](C)c4ccncc4C(=O)OC[C@]4(C)O[C@@]1([C@H](OC(C)=O)[C@H]4[C@@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3959,ML00004516,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004516_numbered.png,2026-03-19 06:56:38.110713
3960,ML00005831,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN([C@H](C)c4ccnc5ncccc45)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005831_numbered.png,2026-03-19 06:56:38.167474
3961,ML00009680,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1C(C)C(C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3962,ML00003708,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@H](C(C)C)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003708_numbered.png,2026-03-19 06:56:38.235161
3963,ML00000974,CHEMBL3736170,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccccc3-c3cn(CCCCCCC(=O)NO)nn3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000974_numbered.png,2026-03-19 06:56:38.290096
3964,ML00009582,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009582_numbered.png,2026-03-19 06:56:38.354177
3965,ML00002931,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H]2[C@H](C)[C@@H](OCN2C2CCCC2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002931_numbered.png,2026-03-19 06:56:38.412346
3966,ML00001707,CHEMBL3912705,,CNC(=O)CNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001707_numbered.png,2026-03-19 06:56:38.447103
3967,ML00000014,CHEMBL414883,RADICICOL,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000014_numbered.png,2026-03-19 06:56:38.471930
3968,ML00003256,,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)N/C=C/c2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003256_numbered.png,2026-03-19 06:56:38.529596
3969,ML00003039,,,CC[C@H](C)[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@H](OC)[C@H]2O)[C@@H](C)C[C@](C)(O)C(=O)[C@H](C)[C@@H](OC(C)=O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003039_numbered.png,2026-03-19 06:56:38.591140
3970,ML00002842,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002842_numbered.png,2026-03-19 06:56:38.650983
3971,ML00003194,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3972,ML00002160,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2cnc3cccnc3c2)C[C@@H](C)/C(=N\OC)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002160_numbered.png,2026-03-19 06:56:38.716057
3973,ML00001085,CHEMBL3828162,,CC(=O)Oc1cc(O)c2c(c1)/C=C/CCC[C@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00001085_numbered.png,2026-03-19 06:56:38.740146
3974,ML00001061,CHEMBL3920268,,CO[C@H]1/C=C\CCC[C@H](C)OC(=O)/C=C/[C@@H](O)/C=C\1,standard_macrolactone,14.0,,,success,,3.0,"[3, 9, 12]",ring_size_14/standard/numbered/ML00001061_numbered.png,2026-03-19 06:56:38.767541
3975,ML00005252,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@](C)(OC)[C@H]2OC(=O)CCOCCOCCCc2ccc3c(c2)c(=O)c(C(=O)O)cn3CC)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005252_numbered.png,2026-03-19 06:56:38.827500
3976,ML00002139,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2C(NC(=O)CSc3cnc4ccccc4n3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002139_numbered.png,2026-03-19 06:56:38.883998
3977,ML00002185,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\Oc3ccc(-c4cnccn4)s3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002185_numbered.png,2026-03-19 06:56:38.940613
3978,ML00007386,,,C/C=C/[C@H](C)CC[C@H](C)[C@@H]1C[C@H](O)C[C@@H](O)C/C(C)=C\[C@H]2O[C@@](O)(CC(=O)O1)C[C@@H](OC(N)=O)[C@H]2C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3979,ML00003806,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C3CCCC3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003806_numbered.png,2026-03-19 06:56:39.007658
3980,ML00004307,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccc(Cl)cc3Cl)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004307_numbered.png,2026-03-19 06:56:39.059969
3981,ML00007756,,,C[C@H]1C/C=C/C(O)C/C=C/C(=O)Cc2cccc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 11]",ring_size_14/standard/numbered/ML00007756_numbered.png,2026-03-19 06:56:39.087934
3982,ML00003711,,,CC[C@H]1OC(=O)[C@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003711_numbered.png,2026-03-19 06:56:39.151472
3983,ML00010214,,,CCC1OC(=O)C(C)C(=O)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)CC(C)C(=O)CCC1(C)O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010214_numbered.png,2026-03-19 06:56:39.202727
3984,ML00006777,,,CC1=CC[C@H]2[C@@H](C=C[C@@H]3[C@H](C)/C=C\C=C/[C@@H](C)OC(=O)[C@H](C)C(=O)/C=C(/O)[C@H]23)C1,standard_macrolactone,14.0,,,success,,5.0,"[3, 8, 11, 13, 14]",ring_size_14/standard/numbered/ML00006777_numbered.png,2026-03-19 06:56:39.236749
3985,ML00004677,,,CCCCCCCCCCCCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004677_numbered.png,2026-03-19 06:56:39.300262
3986,ML00006475,,,CCC(=O)O[C@H]1[C@H](C)O[C@H](O[C@@H]2[C@H](C)C(=O)O[C@@H](CC)C(C)(C)[C@H](O)[C@@H](O)C(=O)[C@H](C)C[C@](C)(O[C@@H]3C[C@H](N(C)C)[C@@H](O)[C@@H](C)O3)[C@H](O[C@H]3O[C@@H](C)C[C@@H](N(C)C)[C@@H]3O)[C@@H]2C)C[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006475_numbered.png,2026-03-19 06:56:39.367928
3987,ML00003466,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CC3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003466_numbered.png,2026-03-19 06:56:39.439780
3988,ML00005751,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccncc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005751_numbered.png,2026-03-19 06:56:39.510369
3989,ML00005772,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2OC(=O)N3Cc2ccccc2)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005772_numbered.png,2026-03-19 06:56:39.584897
3990,ML00003617,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@@H](N)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003617_numbered.png,2026-03-19 06:56:39.653165
3991,ML00002406,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCC(C)(C)n1cnc2ncccc21,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002406_numbered.png,2026-03-19 06:56:39.714286
3992,ML00007152,,,CO[C@H]1/C=C\CC/C=C\C(=O)O[C@H]([C@H](C)C(=O)CCCC2CC(=O)NC(=O)C2)/C(C)=C\[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 6, 7, 8]",ring_size_14/standard/numbered/ML00007152_numbered.png,2026-03-19 06:56:39.751543
3993,ML00007970,,,CC1CC=CC(O)C(O)CCC=Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00007970_numbered.png,2026-03-19 06:56:39.780711
3994,ML00009458,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009458_numbered.png,2026-03-19 06:56:39.843617
3995,ML00007912,,,C[C@@H]1CC(O)/C=C/C(O)C(O)CC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,5.0,"[3, 5, 8, 9, 11]",ring_size_14/standard/numbered/ML00007912_numbered.png,2026-03-19 06:56:39.880680
3996,ML00001705,CHEMBL3936269,,C[C@@H]1OC(=O)c2c(O)cc(NC3CC3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001705_numbered.png,2026-03-19 06:56:39.918563
3997,ML00006104,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CCCc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006104_numbered.png,2026-03-19 06:56:39.990754
3998,ML00002091,CHEMBL122919,,O=C(COc1ccccc1)N[C@H]1COC(=O)CCC[C@H](CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3999,ML00006316,,,CC(=O)O[C@@H]1[C@H]2[C@@H](OC(=O)C(C)C)[C@@H](OC(=O)C(C)C)[C@]3(COC(=O)C(C)C)[C@@H](O)[C@@H](OC(=O)c4ccc(=O)n(C)c4)[C@@H]4OC(=O)[C@@H](C)[C@@H](C)c5ccncc5C(=O)OC[C@]2(C)O[C@]13[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4000,ML00007573,,,COC(=O)c1ccc(COc2cc(O)c3c(c2)C=CCCCC(=O)CCCC(C)OC3=O)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007573_numbered.png,2026-03-19 06:56:40.034391
4001,ML00006785,,,C/C=C1/[C@H]2OC=C(C(=O)OC)[C@H]1CC(=O)OC[C@@H](c1ccc(O)c(O)c1)OC[C@H]1O[C@@H](O2)[C@H](O)[C@@H](O)[C@@H]1O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4002,ML00003055,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@@H](n2ccc(C=O)c2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003055_numbered.png,2026-03-19 06:56:40.107549
4003,ML00008726,,,COc1cc(O)c2c(c1)C=CCC(O)C(O)C(=O)C=CCC(C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008726_numbered.png,2026-03-19 06:56:40.138985
4004,ML00007154,,,CO[C@H]1C=CCCC=CC(=O)O[C@H]([C@H](C)C(=O)CCCC2CC(=O)NC(=O)C2)C(C)=C[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 6, 7, 8]",ring_size_14/standard/numbered/ML00007154_numbered.png,2026-03-19 06:56:40.174084
4005,ML00004578,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNCc2cccnc2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004578_numbered.png,2026-03-19 06:56:40.240225
4006,ML00003994,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4007,ML00007930,,,C[C@H]1C[C@H]2O[C@@H]2CCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007930_numbered.png,2026-03-19 06:56:40.273033
4008,ML00004843,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(OCc4ccccc4)c(OCc4ccccc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004843_numbered.png,2026-03-19 06:56:40.327118
4009,ML00010213,,,CC[C@@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(O)[C@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010213_numbered.png,2026-03-19 06:56:40.387005
4010,ML00000481,CHEMBL273440,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000481_numbered.png,2026-03-19 06:56:40.450424
4011,ML00004513,,,CCCCCCCCNNC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N/OCCCC3CCCCC3)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004513_numbered.png,2026-03-19 06:56:40.517427
4012,ML00010610,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3c(F)cccc3Cl)cc(OCc3c(F)cccc3Cl)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010610_numbered.png,2026-03-19 06:56:40.544393
4013,ML00007940,,,C[C@H]1C/C=C\CCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007940_numbered.png,2026-03-19 06:56:40.569249
4014,ML00004813,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(-c5cccc([N+](=O)[O-])c5)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004813_numbered.png,2026-03-19 06:56:40.635911
4015,ML00002952,,,CCC(CC)CN[C@@H]1[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002952_numbered.png,2026-03-19 06:56:40.700306
4016,ML00003006,,,CC(=O)OCC12C(OC(C)=O)C(OC(C)=O)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)OC(C(OC(=O)c1ccccc1)C2OC(C)=O)C4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4017,ML00005850,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(-c4cccc(N)n4)s3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00005850_numbered.png,2026-03-19 06:56:40.776088
4018,ML00006418,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006418_numbered.png,2026-03-19 06:56:40.848747
4019,ML00000241,CHEMBL83069,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)N2CCCCC2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000241_numbered.png,2026-03-19 06:56:40.879877
4020,ML00007994,,,C[C@@H]1C[C@H](O)[C@@H](O)CCC(=O)O[C@H](C)C/C=C\C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4021,ML00004271,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nc(C)cc(C)n3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004271_numbered.png,2026-03-19 06:56:40.949822
4022,ML00006472,,,CCCCCCCCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006472_numbered.png,2026-03-19 06:56:41.021920
4023,ML00005851,,,C=C[C@]12OC(=O)N(CCCCn3cnc(-c4ccc(F)nc4)c3)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005851_numbered.png,2026-03-19 06:56:41.085449
4024,ML00008896,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC2CCNC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00008896_numbered.png,2026-03-19 06:56:41.155035
4025,ML00007472,,,O=C1CCCC/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N2CCC[C@@H]2CO1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4026,ML00005911,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@@H](C)[C@H]2CC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005911_numbered.png,2026-03-19 06:56:41.222015
4027,ML00004176,,,CCC(=O)OC1C(N(C)C)CC(C)O[C@H]1O[C@H]1[C@H](C)[C@@H](O[C@H]2CC(OC)[C@@H](O)C(C)O2)[C@H](C)C(=O)O[C@@H](CC)[C@](C)(O)[C@@H](O)[C@H](C)C(=O)[C@@H](C)C[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004176_numbered.png,2026-03-19 06:56:41.288764
4028,ML00000776,CHEMBL2159134,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2O/C(=N\C(C)C)N3C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000776_numbered.png,2026-03-19 06:56:41.358157
4029,ML00009797,,,C=C1NC[C@H](C)[C@H](CC[C@@H](C)C(=O)/C=C/C(C)=C/CC[C@@H](C)CCCCCC)OC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](C)CNC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4030,ML00003360,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3ccoc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@@](C)(O)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4031,ML00002199,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc4nc(N)sc4c3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002199_numbered.png,2026-03-19 06:56:41.445495
4032,ML00007468,,,CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)/C=C\c2ccc(O)cc2)[C@@H](C)OC(=O)[C@@H](C)CNC(=O)[C@@H](C)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4033,ML00003469,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003469_numbered.png,2026-03-19 06:56:41.521962
4034,ML00003991,,,CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H]2[C@@H](OC(C)=O)[C@]34O[C@@]2(C)COC(=O)c2cnccc2[C@H](C)[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]13COC(=O)c1ccoc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4035,ML00004492,,,CCCCCCCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@](C)(O)[C@H](OC(=O)CCCCCCC)[C@@H](C)C(=O)[C@H](C)C[C@]2(C)O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004492_numbered.png,2026-03-19 06:56:41.600899
4036,ML00002420,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2C(NC(=O)CCc3ccccc3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002420_numbered.png,2026-03-19 06:56:41.667905
4037,ML00002899,,,CCOC(=O)CCC(=O)OC1C(OC2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)C(C)(O)C(O)C(C)C(=O)C(C)CC2(C)O)OC(C)CC1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002899_numbered.png,2026-03-19 06:56:41.736169
4038,ML00000043,CHEMBL1668418,,COc1cc(O)c2c(c1)/C=C/CCCC(=O)/C=C/C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00000043_numbered.png,2026-03-19 06:56:41.762511
4039,ML00003557,,,COC(=O)NC/C=C\c1nc(CC/C=C\C(=O)O[C@H]2C[C@@H]3CC(=O)O[C@@H](/C=C/CC(C)C)C[C@@H]4CC[C@H](C)[C@@H](C[C@@H](OC)C[C@H](C2)O3)O4)co1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4040,ML00004699,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)(CN(C)Cc3ccc(-c4cn(CC(=O)NO)nn4)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(OC)CC(C)C(=O)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004699_numbered.png,2026-03-19 06:56:41.836707
4041,ML00008432,,,CCC1OC(=O)C(C)CC(C)C(=O)/C(C)=C/C(C)C(=O)/C=C/C1(C)O,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 4, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00008432_numbered.png,2026-03-19 06:56:41.888164
4042,ML00001591,CHEMBL3735677,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CC(=O)NO)nn4)cc3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001591_numbered.png,2026-03-19 06:56:41.947157
4043,ML00009211,,,C=C1COC2[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC1)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@H](CC)[C@@]2(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009211_numbered.png,2026-03-19 06:56:42.006557
4044,ML00001948,CHEMBL125224,,CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)N[C@H]1CCC(=O)OCCCOC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4045,ML00004325,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccc2F)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CC3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004325_numbered.png,2026-03-19 06:56:42.080936
4046,ML00009060,,,C=C1COC2[C@@H](C)/C(=N/C(C)=O)[C@H](C)C[C@@](C)(OC1)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@H](CC)[C@@]2(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009060_numbered.png,2026-03-19 06:56:42.138307
4047,ML00002630,,,CC[C@H]1OC(=O)[C@H](C)C[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00002630_numbered.png,2026-03-19 06:56:42.191731
4048,ML00000111,CHEMBL471474,HYPOTHEMYCIN,COc1cc(O)c2c(c1)[C@H]1O[C@@H]1C[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00000111_numbered.png,2026-03-19 06:56:42.224899
4049,ML00004338,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3cccc(F)c3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004338_numbered.png,2026-03-19 06:56:42.290297
4050,ML00002819,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002819_numbered.png,2026-03-19 06:56:42.346996
4051,ML00003280,,,CC(=O)OC[C@@]12[C@@H](O)[C@@H](OC(=O)c3ccc(=O)n(C)c3)[C@@H]3OC(=O)[C@H](C)[C@@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@]1([C@@H](OC(C)=O)[C@@H]4[C@@H](OC(C)=O)[C@@H]2O)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4052,ML00006461,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4053,ML00007898,,,C[C@H]1CCC[C@H](O)[C@@H](O)CC/C=C\c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00007898_numbered.png,2026-03-19 06:56:42.392568
4054,ML00001258,CHEMBL124616,,COCCOCCOCCOC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)CCC[C@H](CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4055,ML00003396,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)[C@H](OC(=O)O2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003396_numbered.png,2026-03-19 06:56:42.453620
4056,ML00003859,,,CCC1N[C@@H]2[C@H](C)[C@@H](O1)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC1CC(C)(OC)C(O)C(C)O1)[C@H](C)[C@@H](OC1OC(C)CC(N(C)C)C1O)[C@](C)(O)C[C@H]2C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003859_numbered.png,2026-03-19 06:56:42.512334
4057,ML00009770,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1[C@H](C)[C@@H](C)C(=O)O[C@H]([C@H](OC(C)=O)[C@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4058,ML00007804,,,C[C@H]1C[C@H]2O[C@H]2C=CC=CC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007804_numbered.png,2026-03-19 06:56:42.549308
4059,ML00001701,CHEMBL3893740,,CCNc1cc(O)c2c(c1)/C=C/C[C@H](OC(=O)C(F)(F)F)[C@@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001701_numbered.png,2026-03-19 06:56:42.591003
4060,ML00002364,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)/C=C/c2ccc(Br)cc2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002364_numbered.png,2026-03-19 06:56:42.656622
4061,ML00004454,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](COC(=O)c4ccccc4)[C@@H](O)[C@H](O)[C@H]3OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004454_numbered.png,2026-03-19 06:56:42.726184
4062,ML00005951,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NN(C)CCCc2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005951_numbered.png,2026-03-19 06:56:42.784442
4063,ML00003649,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2C(NC(=O)CNC(=O)CSc3cnc4ccccc4n3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003649_numbered.png,2026-03-19 06:56:42.847138
4064,ML00007955,,,C[C@@H]1C[C@H](O)CCCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 5, 11]",ring_size_14/standard/numbered/ML00007955_numbered.png,2026-03-19 06:56:42.880235
4065,ML00001743,CHEMBL3680940,,COc1ccc2c(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)O)C[C@H]5/C=C\CCCCOC(=O)N4C3)nc(Cl)cc2c1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4066,ML00005837,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](C[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)CC(OC/C(=N\OCc3cc(-c4cccc(C(N)=O)n4)no3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005837_numbered.png,2026-03-19 06:56:42.945842
4067,ML00000953,CHEMBL412634,,CC[C@H]1COC(=O)N1C(=O)O[C@H]1[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000953_numbered.png,2026-03-19 06:56:43.007119
4068,ML00007964,,,C[C@H]1C[C@@H](O)CC(=O)CCC/C=C\c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 5, 7]",ring_size_14/standard/numbered/ML00007964_numbered.png,2026-03-19 06:56:43.035627
4069,ML00008330,,,COc1cc(O)c2c(c1)[C@H]1O[C@@H]1CCCC(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008330_numbered.png,2026-03-19 06:56:43.060561
4070,ML00003706,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003706_numbered.png,2026-03-19 06:56:43.130254
4071,ML00003101,,,CCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003101_numbered.png,2026-03-19 06:56:43.205637
4072,ML00003301,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cncc(N)c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00003301_numbered.png,2026-03-19 06:56:43.274937
4073,ML00003615,,,CC[C@H]1OC(=O)[C@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](N)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003615_numbered.png,2026-03-19 06:56:43.340602
4074,ML00008433,,,CC[C@H]1OC(=O)[C@H](C)C(=O)/C(C)=C\[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@@]1(C)O,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 4, 7, 8, 10, 12, 13, 14]",ring_size_14/standard/numbered/ML00008433_numbered.png,2026-03-19 06:56:43.388972
4075,ML00006447,,,CC(=O)OC[C@]12[C@H](OC(=O)c3ccccc3)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4076,ML00001041,CHEMBL1554023,,C[C@H]1COC(=O)[C@H]2CCCN2C(=O)[C@@H](C)COC(=O)[C@H]2CCCN2C1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4077,ML00002615,,,CCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002615_numbered.png,2026-03-19 06:56:43.467910
4078,ML00002609,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H]2[C@H](C)[C@@H](OCN2C(C)C)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002609_numbered.png,2026-03-19 06:56:43.525867
4079,ML00003459,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2ccc(OC)cc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003459_numbered.png,2026-03-19 06:56:43.589231
4080,ML00007966,,,C[C@H]1C/C=C\[C@H](O)[C@@H](O)CC/C=C\c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00007966_numbered.png,2026-03-19 06:56:43.617129
4081,ML00008648,,,COc1cc(O)c2c(c1)CCC[C@H](O)[C@H](O)C(=O)NCC[C@H](C)OC2=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4082,ML00001078,CHEMBL2216826,,CCNc1cc(O)c2c(c1)/C=C/C[C@@H](O)[C@H](O)C(=O)/C=C\[C@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001078_numbered.png,2026-03-19 06:56:43.656163
4083,ML00009310,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4084,ML00006368,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2cncc(C(N)=O)c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006368_numbered.png,2026-03-19 06:56:43.730711
4085,ML00005253,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OP(=O)(Oc3ccccc3)Oc3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)CCNC(=O)OC(C)(C)C)[C@@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005253_numbered.png,2026-03-19 06:56:43.810582
4086,ML00009814,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009814_numbered.png,2026-03-19 06:56:43.883664
4087,ML00003996,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccco4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4088,ML00000088,CHEMBL1423706,,COc1cc2c(c(OCC(=O)NC(C)C)c1)C(=O)O[C@@H](C)CCCC(=O)CCCCC2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00000088_numbered.png,2026-03-19 06:56:43.918014
4089,ML00009801,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nnnn3C)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009801_numbered.png,2026-03-19 06:56:43.976743
4090,ML00006893,,,CCO[C@H]1CC(=O)[C@@H](O)[C@@H](O)C[C@H]2O[C@@H]2c2cc(OC)cc(O)c2C(=O)O[C@@H](C)C1,standard_macrolactone,14.0,,,success,,5.0,"[3, 5, 7, 8, 9]",ring_size_14/standard/numbered/ML00006893_numbered.png,2026-03-19 06:56:44.012948
4091,ML00007085,,,COC1/C=C/C(C)(O)C(SCC(N)C(=O)O)CC(=O)OC(C)C(C)CC/C=C/1C,standard_macrolactone,14.0,,,success,,7.0,"[3, 4, 8, 9, 12, 12, 13]",ring_size_14/standard/numbered/ML00007085_numbered.png,2026-03-19 06:56:44.054012
4092,ML00007905,,,CC1CCCC(O)CCCC=Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007905_numbered.png,2026-03-19 06:56:44.078641
4093,ML00003140,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CNC(=O)OCc3ccc4cccnc4c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003140_numbered.png,2026-03-19 06:56:44.133815
4094,ML00009496,,,COc1ccc(CCOc2ccc(C3CC(=O)Oc4cc5c(c(OC)c43)C(=O)OC(C)CCCC(=O)CCCC=C5)cc2)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00009496_numbered.png,2026-03-19 06:56:44.160180
4095,ML00003244,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4096,ML00009501,,,C[C@H]1OC(=O)CCNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]1NC(=O)Cc1ccccc1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4097,ML00005490,,,CC[C@H]1OC(=O)[C@H](C)C(O[C@H]2C[C@](C)(OC)[C@@H](O)[C@@H](C)O2)[C@H](C)C(O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCOc2ccccc2OC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005490_numbered.png,2026-03-19 06:56:44.239380
4098,ML00001756,CHEMBL521220,,C/C1=C/[C@@H](C)[C@H](O)C/C=C/CC/C=C/C(=O)O[C@@H]1[C@H](C)C(=O)/C=C/CC1CC(=O)NC(=O)C1,standard_macrolactone,14.0,,,success,,4.0,"[3, 4, 6, 7]",ring_size_14/standard/numbered/ML00001756_numbered.png,2026-03-19 06:56:44.274092
4099,ML00008537,,,C[C@H]1CCC[C@H](O)CCC[C@H](O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 11]",ring_size_14/standard/numbered/ML00008537_numbered.png,2026-03-19 06:56:44.303449
4100,ML00010816,,,COc1c2c(cc3c1C(c1ccc(OC(C)C)cc1)CC(=O)O3)C=CCCCC(=O)CCCC(C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010816_numbered.png,2026-03-19 06:56:44.329098
4101,ML00004156,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004156_numbered.png,2026-03-19 06:56:44.392902
4102,ML00006483,,,CCc1cc(O)cc(Cc2cc3c(cc2OOC2C4OCC(N)C(NC)CC#CC(C(=O)O)C(=O)OCC(O4)C(OCCCO)C2O)C2Oc4c(cc5c(c4CC(C)C)OCO5)C2CO3)c1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4103,ML00001838,CHEMBL569599,,C[C@@H]1C[C@@H](O)[C@H](Cl)/C=C\C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 6, 11]",ring_size_14/standard/numbered/ML00001838_numbered.png,2026-03-19 06:56:44.432635
4104,ML00006201,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC/C=C/c2ccc(-n3ccnc3)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2Cl)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006201_numbered.png,2026-03-19 06:56:44.495418
4105,ML00007500,,,CCCCCCC[C@H]1CC(=O)N[C@@H](CO)C(=O)O[C@H](CCCCCC)CC(=O)N[C@@H](CO)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4106,ML00008538,,,C[C@H]1CCC[C@@H](O)[C@@H](O)CCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00008538_numbered.png,2026-03-19 06:56:44.530268
4107,ML00007704,,,C[C@@H]1C/C=C\CC/C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007704_numbered.png,2026-03-19 06:56:44.555555
4108,ML00001395,CHEMBL338008,,O=C1CCC[C@H](CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)OCCN2CCOCC2)CO1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4109,ML00007817,,,C[C@@H]1C[C@@H]2O[C@@H]2/C=C\C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007817_numbered.png,2026-03-19 06:56:44.589150
4110,ML00006196,,,CCCCCCCCCCCCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006196_numbered.png,2026-03-19 06:56:44.658773
4111,ML00003238,,,CC(=O)OCC12C(OC(C)=O)C(OCOc3ccccc3)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)OC(C(OC(C)=O)C2OC(C)=O)C4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4112,ML00005891,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2cnc(N)nc2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005891_numbered.png,2026-03-19 06:56:44.730222
4113,ML00008801,,,CC[C@@H]1OC(=O)CCCCCCC/C=C\[C@H]2[C@H]1C[C@@H](I)[C@@H]2O,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008801_numbered.png,2026-03-19 06:56:44.760203
4114,ML00001674,CHEMBL1096741,,C[C@@H]1OC(=O)c2c(O)cc(N3CCNCC3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001674_numbered.png,2026-03-19 06:56:44.795202
4115,ML00004732,,,CCCc1nc2cc(C(=O)NNC(=O)O[C@H]3[C@H](C)O[C@@H](O[C@H]4[C@H](C)[C@@H](O[C@@H]5O[C@H](C)C[C@H](N(C)C)[C@H]5O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]4C)C[C@@]3(C)OC)ccc2[nH]1,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004732_numbered.png,2026-03-19 06:56:44.860861
4116,ML00010609,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3ccc(Cl)c(Cl)c3)cc(OCc3ccc(Cl)c(Cl)c3)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010609_numbered.png,2026-03-19 06:56:44.886293
4117,ML00007313,,,C=C[C@H]1[C@H]2OC=C(C(=O)OC)[C@H]1C[C@@H]1N[C@@H](Cc3c1[nH]c1ccccc31)C(=O)OC[C@@H]1O[C@H](O2)[C@H](O)[C@@H](O)[C@@H]1O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4118,ML00004329,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccc([N+](=O)[O-])cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CC3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004329_numbered.png,2026-03-19 06:56:44.958662
4119,ML00003303,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4ccncc4Br)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003303_numbered.png,2026-03-19 06:56:45.015957
4120,ML00004716,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc(-c5cncnc5)c4)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004716_numbered.png,2026-03-19 06:56:45.081259
4121,ML00002608,,,CCCCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002608_numbered.png,2026-03-19 06:56:45.149016
4122,ML00006506,,,CC(=O)OC[C@]12[C@H](OC(=O)c3ccccc3)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4123,ML00003237,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@@H](OCOc3ccccc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4124,ML00001812,CHEMBL3334711,,COc1cc(O)cc2c1C(=O)O[C@@H](C)CCC(=O)CC/C=C/C(=O)C2,standard_macrolactone,14.0,,,success,,3.0,"[3, 6, 11]",ring_size_14/standard/numbered/ML00001812_numbered.png,2026-03-19 06:56:45.192952
4125,ML00002370,,,C=C[C@]12OC(=O)N(CCCCn3cnc4cccnc43)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002370_numbered.png,2026-03-19 06:56:45.249493
4126,ML00006634,,,O=C1OCC/C=C/CC/C=C/C(=N/OCC(=O)N2CCCCC2)Cc2c(Cl)c(O)cc(OP(=O)(O)O)c21,standard_macrolactone,14.0,,,success,,1.0,[11],ring_size_14/standard/numbered/ML00006634_numbered.png,2026-03-19 06:56:45.272640
4127,ML00006288,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006288_numbered.png,2026-03-19 06:56:45.336771
4128,ML00003488,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3ccoc3C)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003488_numbered.png,2026-03-19 06:56:45.399871
4129,ML00003042,,,COC1C(OC2C(C)CC(C)(OC)C(=O)C(C)C(OC(C)=O)C(C)C(C(C)C(C)O)OC(=O)C(C)C(OC3OC(C)CC(O)C3O)C2C)OC(C)C(OC(C)=O)C1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003042_numbered.png,2026-03-19 06:56:45.472815
4130,ML00003353,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(=O)c1ccccc1)[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4131,ML00008347,,,COc1cc(O)cc2c1C(=O)OC(C)CCCC(=O)CCC/C=C\2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008347_numbered.png,2026-03-19 06:56:45.533895
4132,ML00008544,,,CC[C@@H]1OC(=O)CCCC/C=C\C/C=C\[C@H]2[C@H]1C[C@@H](I)[C@@H]2O,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008544_numbered.png,2026-03-19 06:56:45.557464
4133,ML00005829,,,C=C[C@]12OC(=O)N(CCCCn3cnc(-c4cccnc4)c3)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005829_numbered.png,2026-03-19 06:56:45.616669
4134,ML00008804,,,CC[C@@H]1OC(=O)CCCCCCC/C=C\[C@H]2[C@H]1C[C@@H](Cl)[C@@H]2O,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008804_numbered.png,2026-03-19 06:56:45.641431
4135,ML00007759,,,COc1cc(O)c2c(c1Br)C(=O)OCC(=O)NCC(=O)N[C@H](c1nc(CN)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4136,ML00007393,,,COc1cc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)ccc1O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007393_numbered.png,2026-03-19 06:56:45.675548
4137,ML00003027,,,CC(=O)O[C@H]1[C@@H]2OC(=O)[C@H](C)[C@H](C)c3ncccc3C(=O)OC[C@]3(C)O[C@@]4([C@H](OC(C)=O)[C@H]3[C@H](OC(C)=O)[C@@H](COC(=O)c3ccccc3)[C@]4(OC(C)=O)[C@H]1OC(C)=O)[C@@]2(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4138,ML00006114,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](OC(=O)CC(=O)OCc3ccc(N=[N+]=[N-])cc3)[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006114_numbered.png,2026-03-19 06:56:45.752077
4139,ML00004645,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OCCNCCCOCCCNCc2ccc(Oc3ccccc3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004645_numbered.png,2026-03-19 06:56:45.817656
4140,ML00002953,,,CCCCCCN[C@@H]1[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002953_numbered.png,2026-03-19 06:56:45.882351
4141,ML00005995,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3cccnc3)[C@@H]3[C@@H](OC(=O)c4ccco4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4142,ML00004317,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC/C(=N\Oc3ccccc3Cl)CCO[C@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]3NC(=O)O[C@]13C)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004317_numbered.png,2026-03-19 06:56:45.941210
4143,ML00007257,,,CO[C@H]1/C=C/CC/C=C/C(=O)O[C@H]([C@H](C)C(=O)/C=C/CC2CC(=O)NC(=O)C2)/C(C)=C\[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 6, 7, 8]",ring_size_14/standard/numbered/ML00007257_numbered.png,2026-03-19 06:56:45.976707
4144,ML00010237,,,CCC1OC(=O)C(C)C(OC2CC(C)(O)C(O)C(C)O2)C(C)C(O)C(C)(O)CC(C)C(=O)C(C)C(O)C1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010237_numbered.png,2026-03-19 06:56:46.034720
4145,ML00003572,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3cccc(O)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003572_numbered.png,2026-03-19 06:56:46.087589
4146,ML00007937,,,C[C@@H]1C[C@@H](O)CC/C=C/CC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 5, 11]",ring_size_14/standard/numbered/ML00007937_numbered.png,2026-03-19 06:56:46.115504
4147,ML00003476,,,CC[C@H]1OC(=O)[C@H](C)[C@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003476_numbered.png,2026-03-19 06:56:46.173678
4148,ML00006489,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#CCCc2ccc(-c3ccccn3)cc2)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006489_numbered.png,2026-03-19 06:56:46.227460
4149,ML00007761,,,COc1cc(O)c2c(c1Br)C(=O)OCC(=O)NCC(=S)N[C@H](c1nc(CN)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4150,ML00000856,CHEMBL333073,,CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)N[C@H]1COC(=O)CCCC(CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4151,ML00008133,,,CSCC[C@@H]1NC(=O)C/C=C\[C@@H](C)COC(=O)[C@H](C)COC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4152,ML00004345,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)c2ccc(F)cc2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004345_numbered.png,2026-03-19 06:56:46.307332
4153,ML00001787,CHEMBL1098080,,CCn1cnc2c3c(c(O)cc21)C(=O)O[C@@H](C)[C@H](C)/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/3,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001787_numbered.png,2026-03-19 06:56:46.341642
4154,ML00003045,,,CO[C@H]1C[C@@H](C)O[C@@H](O[C@H]2[C@H](C)C[C@](C)(O)C(=O)[C@H](C)[C@@H](OC(C)=O)[C@@H](C)[C@@H]([C@@H](C)[C@H](C)O)OC(=O)[C@H](C)[C@@H](O[C@H]3C[C@@](C)(OC)[C@H](OC(C)=O)[C@H](C)O3)[C@@H]2C)[C@@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003045_numbered.png,2026-03-19 06:56:46.404214
4155,ML00005803,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005803_numbered.png,2026-03-19 06:56:46.470234
4156,ML00003356,,,CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H]2[C@@H](O)[C@@]34O[C@@]2(C)COC(=O)c2cnccc2[C@H](C)[C@](C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]13COC(=O)c1ccoc1)[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4157,ML00001804,CHEMBL3629246,,COc1c(Br)c(O)c2c(c1Br)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001804_numbered.png,2026-03-19 06:56:46.509199
4158,ML00001755,CHEMBL84955,,CCN(CC)CCNC(=O)CO/N=C1\C=C\C=C/[C@H]2O[C@@H]2C[C@@H](C)OC(=O)c2c(O)cc(O)c(Cl)c2C1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00001755_numbered.png,2026-03-19 06:56:46.533806
4159,ML00007702,,,C[C@@H]1C/C=C/CCC=CC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007702_numbered.png,2026-03-19 06:56:46.558020
4160,ML00002799,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC/C(=N\OCCCc3ccccc3)CCO[C@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]3NC(=O)O[C@]13C)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00002799_numbered.png,2026-03-19 06:56:46.606985
4161,ML00007712,,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C/C(=O)C[C@@H]2C(Cl)=C(O)C=C(O)[C@@H]2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007712_numbered.png,2026-03-19 06:56:46.632250
4162,ML00000019,CHEMBL2012519,,COc1cc(O)c2c(c1)CCC[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00000019_numbered.png,2026-03-19 06:56:46.662630
4163,ML00008335,,,COc1cc(O)c2c(c1)[C@H]1O[C@@H]1CC[C@H](O)[C@@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00008335_numbered.png,2026-03-19 06:56:46.690529
4164,ML00006221,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006221_numbered.png,2026-03-19 06:56:46.749887
4165,ML00002987,,,CNC1CC#CC(C(=O)O)C(=O)OCC2OC(OCC1N)C(OOc1cc3c(cc1Cc1cccc(O)c1)OCC1c4cc5c(c(CC(C)C)c4OC31)OCO5)C(O)C2O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4166,ML00009705,,,CC(=O)OC[C@]12[C@H](O)[C@H](OC(C)=O)[C@H]3OC(=O)[C@@H](C)[C@H](C)c4ccncc4C(=O)OC[C@]4(C)O[C@@]1([C@@H](OC(C)=O)[C@H]4[C@@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4167,ML00000632,CHEMBL3828591,,CCOc1cc(O)c2c(c1)/C=C/CCC[C@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00000632_numbered.png,2026-03-19 06:56:46.789117
4168,ML00000867,CHEMBL333234,,CC(C)(C)CC1CCCC(=O)OC[C@H](NC(=O)C(Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC2CCCCC2)[C@@H](O)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4169,ML00010513,,,COC1C(=O)OC2C(O)CO/C=C\C3=C(CCC(=O)OCC2C=C(C)C24OC5CC(O)C2C(C=CC4C1OC)C5)C(=O)OC3=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4170,ML00006426,,,CC/C=N/C(=O)CCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006426_numbered.png,2026-03-19 06:56:46.865659
4171,ML00008101,,,C[C@H]1CCCC(=O)[C@@H]2O[C@@H]2/C=C\[C@@H](O)/C=C\C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 12]",ring_size_14/standard/numbered/ML00008101_numbered.png,2026-03-19 06:56:46.894525
4172,ML00006504,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4173,ML00010228,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010228_numbered.png,2026-03-19 06:56:46.952138
4174,ML00006337,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1cccnc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4175,ML00005842,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4c(OC)cnc5ccccc45)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005842_numbered.png,2026-03-19 06:56:47.016334
4176,ML00002222,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1cccnc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4177,ML00006304,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](OC(=O)CC(=O)OCc3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006304_numbered.png,2026-03-19 06:56:47.089438
4178,ML00004254,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2cccnc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2CC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004254_numbered.png,2026-03-19 06:56:47.146378
4179,ML00003279,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2cccnc2)C[C@@H](C)/C(=N\O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00003279_numbered.png,2026-03-19 06:56:47.207400
4180,ML00003741,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cccnc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003741_numbered.png,2026-03-19 06:56:47.276384
4181,ML00001901,CHEMBL1301249,,COc1cc2c(c(OC)c1)C(=O)OC(C)CCCC(=O)CCCCC2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00001901_numbered.png,2026-03-19 06:56:47.302186
4182,ML00003217,,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)N/C=C/c2ccc(-c3cnccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003217_numbered.png,2026-03-19 06:56:47.360572
4183,ML00007707,,,C[C@@H]1C[C@@H](O)/C=C\C=C/CC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 5, 11]",ring_size_14/standard/numbered/ML00007707_numbered.png,2026-03-19 06:56:47.389598
4184,ML00002170,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CNC(=O)NCc3ccc4nccnc4c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002170_numbered.png,2026-03-19 06:56:47.445988
4185,ML00006899,,,C=C1/C=C(\C)[C@H](CC)OC(=O)[C@H](C)C(=O)[C@@](O)(CO)C/C(OC)=C/[C@@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00006899_numbered.png,2026-03-19 06:56:47.495413
4186,ML00009630,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC/C=C/c2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009630_numbered.png,2026-03-19 06:56:47.560857
4187,ML00005897,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NN(C)C/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005897_numbered.png,2026-03-19 06:56:47.620688
4188,ML00007722,,,C[C@H]1C[C@@H]2O[C@@H]2/C=C\C=C/C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007722_numbered.png,2026-03-19 06:56:47.647201
4189,ML00004754,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccncc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004754_numbered.png,2026-03-19 06:56:47.708293
4190,ML00003995,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccco4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4191,ML00005858,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CC(C)(C)C[C@@H]2c2ccc(Cl)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005858_numbered.png,2026-03-19 06:56:47.779140
4192,ML00010218,,,CCCCCCCCC[C@H]1CC(=O)N[C@@H](CO)C(=O)O[C@H](CCCCCCC)CC(=O)N[C@@H](CO)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4193,ML00006627,,,C/C=C1/[C@H]2OC=C(C(=O)O)[C@H]1CC(=O)OC[C@@H](c1ccc(O)c(O)c1)OC[C@H]1O[C@@H](O2)[C@H](O)[C@@H](O)[C@@H]1O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4194,ML00003034,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4195,ML00006735,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3ccccc3Br)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00006735_numbered.png,2026-03-19 06:56:47.824176
4196,ML00010229,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010229_numbered.png,2026-03-19 06:56:47.872878
4197,ML00004180,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](C3CCC3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004180_numbered.png,2026-03-19 06:56:47.938101
4198,ML00009356,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@H](O)[C@H]3[C@@H](OC(C)=O)[C@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@H]([C@H](O)[C@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4199,ML00009018,,,CO[C@H]1C[C@H](O[C@@H]2[C@H](C)C(=O)O[C@@H](C)[C@H](C)[C@@H](O)[C@@H](C)C(=O)[C@]3(CO3)C[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)C[C@H](N(C)C)[C@H]3O)[C@@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009018_numbered.png,2026-03-19 06:56:48.000037
4200,ML00003562,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003562_numbered.png,2026-03-19 06:56:48.057920
4201,ML00006411,,,CC[C@H]1OC(=O)[C@H](C)C(O[C@H]2C[C@](C)(OC)[C@@H](O)[C@@H](C)O2)[C@H](C)C(O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCOc2ccc(OC)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006411_numbered.png,2026-03-19 06:56:48.124611
4202,ML00002469,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC/C(=N/OCc3ccccc3)CCO[C@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]3NC(=O)O[C@]13C)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00002469_numbered.png,2026-03-19 06:56:48.174970
4203,ML00004315,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC/C(=N\Oc3ccc(Cl)cc3)CCO[C@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]3NC(=O)O[C@]13C)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004315_numbered.png,2026-03-19 06:56:48.225200
4204,ML00010254,,,COc1cc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc(OC)c1O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010254_numbered.png,2026-03-19 06:56:48.250728
4205,ML00008407,,,COc1cc2c(c(OC)c1)C(=O)OC(C)CCC/C(=N/O)CCCCC2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008407_numbered.png,2026-03-19 06:56:48.276399
4206,ML00006064,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N(CC)CC)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006064_numbered.png,2026-03-19 06:56:48.336144
4207,ML00010761,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)C2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010761_numbered.png,2026-03-19 06:56:48.398056
4208,ML00000920,CHEMBL405286,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCNC(=O)CCC3=CC4=Cc5c(C)cc(C)n5[B-](F)(F)[N+]4=C3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](NC(=O)OCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000920_numbered.png,2026-03-19 06:56:48.468063
4209,ML00000376,CHEMBL1668412,,COc1cc(O)c2c(c1)/C=C/CCCC(=O)C[C@H](Cl)C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 5, 7]",ring_size_14/standard/numbered/ML00000376_numbered.png,2026-03-19 06:56:48.496967
4210,ML00006956,,,CC[C@@H]1OC(=O)[C@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C[C@H](C)C(=O)/C=C\[C@@]1(C)O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006956_numbered.png,2026-03-19 06:56:48.546775
4211,ML00002821,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCn1cnc(-c2ccc(C)nc2)c1,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002821_numbered.png,2026-03-19 06:56:48.600532
4212,ML00004311,,,C#CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccc3[N+](=O)[O-])[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004311_numbered.png,2026-03-19 06:56:48.666088
4213,ML00006273,,,CCc1nc2cc(C(=O)NNC(=O)O[C@H]3[C@H](C)O[C@@H](O[C@H]4[C@H](C)[C@@H](O[C@@H]5O[C@H](C)C[C@H](N(C)C)[C@H]5O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]4C)C[C@@]3(C)OC)ccc2[nH]1,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006273_numbered.png,2026-03-19 06:56:48.733066
4214,ML00007902,,,C[C@H]1CCC[C@@H](O)CCC/C=C/c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007902_numbered.png,2026-03-19 06:56:48.757935
4215,ML00008503,,,COc1cc(O)c2c(c1OC)/C=C\C[C@@H](O)[C@@H](O)C(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008503_numbered.png,2026-03-19 06:56:48.790134
4216,ML00004422,,,CC[C@H]1OC(=O)[C@H](C)C(OC/C=C/c2ccnc3ccccc23)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccnc3ccccc23)[C@H](C)[C@@H]2OC(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004422_numbered.png,2026-03-19 06:56:48.850393
4217,ML00006289,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006289_numbered.png,2026-03-19 06:56:48.916603
4218,ML00004316,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC/C(=N\Oc3cccc(Cl)c3)CCO[C@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]3NC(=O)O[C@]13C)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004316_numbered.png,2026-03-19 06:56:48.968901
4219,ML00010242,,,COC(=O)c1ccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010242_numbered.png,2026-03-19 06:56:48.994443
4220,ML00007574,,,O=C(C[C@@H]1C/C=C/CCCCC(=O)O[C@@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4221,ML00001817,CHEMBL3828245,,COc1cc(O)c2c(c1Cl)/C=C/CCCC(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00001817_numbered.png,2026-03-19 06:56:49.024981
4222,ML00006454,,,CC(=O)OC[C@]12[C@H](OC(=O)c3ccccc3)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4223,ML00001714,CHEMBL1096417,,CCCNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001714_numbered.png,2026-03-19 06:56:49.066784
4224,ML00009427,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009427_numbered.png,2026-03-19 06:56:49.123887
4225,ML00007911,,,C[C@H]1C[C@@H](O)/C=C\[C@H](O)CCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 8, 11]",ring_size_14/standard/numbered/ML00007911_numbered.png,2026-03-19 06:56:49.155387
4226,ML00005679,,,CCCCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc(-c5cccnc5)c4)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005679_numbered.png,2026-03-19 06:56:49.210946
4227,ML00003735,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC/C=C/c2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\O)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003735_numbered.png,2026-03-19 06:56:49.268621
4228,ML00010133,,,O=C1CCCC/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)CO1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4229,ML00006557,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006557_numbered.png,2026-03-19 06:56:49.341712
4230,ML00007802,,,C/C1=C/C=C\[C@](C)(O)CCC(=O)O[C@@H](C)[C@@H](C)CC[C@H]1O,standard_macrolactone,14.0,,,success,,6.0,"[3, 4, 7, 8, 12, 12]",ring_size_14/standard/numbered/ML00007802_numbered.png,2026-03-19 06:56:49.380150
4231,ML00008693,,,CCCCC[C@@H]1CCCCC[C@@H](O)C[C@@H](O)[C@H](O)/C=C/C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 9, 11, 12]",ring_size_14/standard/numbered/ML00008693_numbered.png,2026-03-19 06:56:49.410675
4232,ML00004339,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccc(F)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CC3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004339_numbered.png,2026-03-19 06:56:49.478233
4233,ML00001691,CHEMBL1095162,,C[C@@H]1OC(=O)c2c(O)cc(OCCn3ccnc3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001691_numbered.png,2026-03-19 06:56:49.517914
4234,ML00005729,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2ccc(N)nc2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005729_numbered.png,2026-03-19 06:56:49.581761
4235,ML00008382,,,COc1cc(O)c(Cl)c2c1C(=O)O[C@@H](C)CC[C@@H](O)CCCCC(=O)C2,standard_macrolactone,14.0,,,success,,3.0,"[3, 6, 11]",ring_size_14/standard/numbered/ML00008382_numbered.png,2026-03-19 06:56:49.610843
4236,ML00006983,,,CCNc1cc(O)c2c(c1)CCCC(=O)C(=O)C(=O)CC[C@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00006983_numbered.png,2026-03-19 06:56:49.645150
4237,ML00005862,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCC(C)(C)n1cnc(-c2cccnc2)c1,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005862_numbered.png,2026-03-19 06:56:49.698234
4238,ML00006555,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C(=O)CNCCNCc3ccccc3)[C@@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006555_numbered.png,2026-03-19 06:56:49.762817
4239,ML00001490,CHEMBL3650150,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(=O)N3CCOCC3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)C2N(CCCOc3cc(C(=O)Nc4c(Cl)cncc4Cl)ccc3OC)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001490_numbered.png,2026-03-19 06:56:49.819886
4240,ML00009145,,,COc1c2c(cc3c1C(c1cc4cccc5c4n(c1=O)CCC5)CC(=O)O3)C=CCCCC(=O)CCCC(C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00009145_numbered.png,2026-03-19 06:56:49.846336
4241,ML00006907,,,C=C1/C=C(/C)[C@H](CC)OC(=O)[C@H](C)C(=O)[C@](O)(CO)C/C(C)=C\[C@@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00006907_numbered.png,2026-03-19 06:56:49.897069
4242,ML00002763,,,C=C[C@]12OC(=O)N(CCCCn3cnc(-c4cnccn4)c3)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002763_numbered.png,2026-03-19 06:56:49.959524
4243,ML00003169,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NN(C)Cc2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003169_numbered.png,2026-03-19 06:56:50.035510
4244,ML00006840,,,C=C1CC/C=C\[C@H](O)[C@H](C)/C=C\[C@H]([C@H](O)[C@H](C)/C=C/CCC)OC(=O)C[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 6, 7, 12, 13]",ring_size_14/standard/numbered/ML00006840_numbered.png,2026-03-19 06:56:50.076627
4245,ML00000936,CHEMBL12666,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCCC2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000936_numbered.png,2026-03-19 06:56:50.144976
4246,ML00006469,,,CCCCCCCCCCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006469_numbered.png,2026-03-19 06:56:50.220875
4247,ML00006200,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NN)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006200_numbered.png,2026-03-19 06:56:50.296889
4248,ML00005531,,,CCCCCCCC(=O)O[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005531_numbered.png,2026-03-19 06:56:50.369463
4249,ML00001688,CHEMBL557444,,C[C@@H]1C[C@H]2O[C@@H]2C(Sc2ccccc2)/C=C\CC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 11]",ring_size_14/standard/numbered/ML00001688_numbered.png,2026-03-19 06:56:50.404398
4250,ML00002595,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NCCCCN)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002595_numbered.png,2026-03-19 06:56:50.476795
4251,ML00007398,,,COc1c2c(cc3c1C(c1ccccc1)CC(=O)O3)C=CCCCC(=O)CCCC(C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007398_numbered.png,2026-03-19 06:56:50.506722
4252,ML00010448,,,COc1cc2c(c(OCC(=O)Nc3ccc4c(c3)OCCO4)c1)C(=O)OC(C)CCCC(=O)CCCCC2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010448_numbered.png,2026-03-19 06:56:50.534176
4253,ML00002362,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)/C=C/c2ccccc2Cl)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002362_numbered.png,2026-03-19 06:56:50.606021
4254,ML00000771,CHEMBL334627,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3cccnc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000771_numbered.png,2026-03-19 06:56:50.671347
4255,ML00002249,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](O)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@@H]2NC(=S)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002249_numbered.png,2026-03-19 06:56:50.734012
4256,ML00001308,CHEMBL264900,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](OC(=O)CC(=O)O)[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001308_numbered.png,2026-03-19 06:56:50.806034
4257,ML00002820,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002820_numbered.png,2026-03-19 06:56:50.872522
4258,ML00008348,,,COc1cc(O)cc2c1C(=O)OC(C)CCCC(=O)CCCC=C2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008348_numbered.png,2026-03-19 06:56:50.900003
4259,ML00008778,,,CO[C@H]1/C=C\[C@@](C)(O)/C=C\C(=O)O[C@H](C)[C@@H](C)[C@@H](O)C/C=C\1C,standard_macrolactone,14.0,,,success,,7.0,"[3, 4, 5, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00008778_numbered.png,2026-03-19 06:56:50.942782
4260,ML00004665,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4ccc(N)nc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004665_numbered.png,2026-03-19 06:56:51.003384
4261,ML00010589,,,C=C(C)COc1ccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1OC,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010589_numbered.png,2026-03-19 06:56:51.096710
4262,ML00004731,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(C(C)C)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004731_numbered.png,2026-03-19 06:56:51.174783
4263,ML00009510,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCCCc2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009510_numbered.png,2026-03-19 06:56:51.243709
4264,ML00003094,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NC2CCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003094_numbered.png,2026-03-19 06:56:51.310978
4265,ML00001212,CHEMBL335696,,C=CCO[C@]1(C)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001212_numbered.png,2026-03-19 06:56:51.377508
4266,ML00004745,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc(-c5ccco5)c4)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004745_numbered.png,2026-03-19 06:56:51.437463
4267,ML00003259,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2cccs2)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003259_numbered.png,2026-03-19 06:56:51.492420
4268,ML00006818,,,C[C@H]1CCCC(=O)CCC/C=C/c2cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00006818_numbered.png,2026-03-19 06:56:51.518293
4269,ML00005756,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005756_numbered.png,2026-03-19 06:56:51.581426
4270,ML00000800,CHEMBL2047341,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4271,ML00002571,,,CCC(=O)O[C@H]1[C@H](C)O[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](OC(=O)CC)[C@@H](C)C(=O)[C@]3(CO3)C[C@H](C)[C@H](O[C@@H]3O[C@@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]2C)C[C@@H]1OC,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002571_numbered.png,2026-03-19 06:56:51.648270
4272,ML00006345,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)C(C)C)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006345_numbered.png,2026-03-19 06:56:51.714673
4273,ML00000010,CHEMBL532,ERYTHROMYCIN,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000010_numbered.png,2026-03-19 06:56:51.794744
4274,ML00000358,CHEMBL84564,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)NCCc2cccn2C)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000358_numbered.png,2026-03-19 06:56:51.825754
4275,ML00006020,,,CCc1cc(O)cc(Cc2cc3c(cc2OOC2C4OCC(N)C(NC)CC#CC(C(=O)O)C(=O)OCC(O4)C(O)C2O)C2Oc4c(cc5c(c4CC(C)C)OCO5)C2CO3)c1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4276,ML00002159,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@H]2C[C@@H](N(C)C)C[C@@H](C)O2)[C@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002159_numbered.png,2026-03-19 06:56:51.901420
4277,ML00000012,CHEMBL532,ERYTHROMYCIN,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000012_numbered.png,2026-03-19 06:56:51.976085
4278,ML00004177,,,CCC(=O)OC1C(OC2C(C)C(OC3CC(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)C(C)(O)C(O)C(C)C(=O)C(C)CC2(C)O)OC(C)CC1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004177_numbered.png,2026-03-19 06:56:52.048003
4279,ML00003214,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](O)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3cnccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@@H]2NC(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003214_numbered.png,2026-03-19 06:56:52.116061
4280,ML00001315,CHEMBL1476500,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=NOCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001315_numbered.png,2026-03-19 06:56:52.190868
4281,ML00003590,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccncc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)[C@H](OC(=O)O2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003590_numbered.png,2026-03-19 06:56:52.253047
4282,ML00001383,CHEMBL1256550,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001383_numbered.png,2026-03-19 06:56:52.324969
4283,ML00007839,,,CC1C/C=C/CCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007839_numbered.png,2026-03-19 06:56:52.352830
4284,ML00003847,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003847_numbered.png,2026-03-19 06:56:52.425066
4285,ML00008551,,,CC1CCCC(O)CCCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008551_numbered.png,2026-03-19 06:56:52.451059
4286,ML00005255,,,C=CCCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](OP(=O)(Oc4ccccc4)Oc4ccccc4)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@](C)(O)[C@H](OC(=O)CCC=C)[C@@H](C)C(=O)[C@H](C)C[C@]2(C)O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005255_numbered.png,2026-03-19 06:56:52.525346
4287,ML00005680,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=N\OCc3cc(-c4ccc(Br)c(OC)c4OC)no3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005680_numbered.png,2026-03-19 06:56:52.588688
4288,ML00009745,,,CCCNCCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009745_numbered.png,2026-03-19 06:56:52.662266
4289,ML00007944,,,C[C@@H]1C/C=C/CCCCC(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007944_numbered.png,2026-03-19 06:56:52.690370
4290,ML00009123,,,CC[C@H]1OC(=O)[C@H](C)[C@@]2(O)O[C@@](C)(C[C@@H](C)CN3/C(=N\C(C)C)O[C@H]([C@H]3C)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4291,ML00006693,,,O=C1CCCC/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NCCO1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4292,ML00007979,,,C[C@@H]1CCCCCC/C=C\CCCC(=O)O1,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00007979_numbered.png,2026-03-19 06:56:52.730929
4293,ML00006636,,,C[C@@H]1C[C@H]2O[C@@H]2[C@H](Sc2ccccc2)CCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 11]",ring_size_14/standard/numbered/ML00006636_numbered.png,2026-03-19 06:56:52.765483
4294,ML00006041,,,C=CCCCCCCCCCN[C@@H]1[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006041_numbered.png,2026-03-19 06:56:52.842051
4295,ML00004299,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2C(NC(=O)CCc3ccccn3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004299_numbered.png,2026-03-19 06:56:52.912266
4296,ML00005372,,,CCCCCCCCCCCCCCNNC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N/OCCCC3CCCCC3)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005372_numbered.png,2026-03-19 06:56:52.992608
4297,ML00002489,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002489_numbered.png,2026-03-19 06:56:53.070456
4298,ML00009411,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)/C(=N\O)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009411_numbered.png,2026-03-19 06:56:53.141744
4299,ML00004837,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCCCc2cncc(NC(=O)Cc3ccccn3)c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004837_numbered.png,2026-03-19 06:56:53.214875
4300,ML00000769,CHEMBL435997,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2ccc3nccnc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000769_numbered.png,2026-03-19 06:56:53.283043
4301,ML00010209,,,CCCCCC/C=C\C[C@@H]1CC(=O)N[C@@H](CO)C(=O)O[C@@H](CCCCCCC)CC(=O)N[C@@H](CO)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4302,ML00003873,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCC(=O)NCCc2ccc(O)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003873_numbered.png,2026-03-19 06:56:53.365079
4303,ML00008411,,,COc1cc2c(c(OC)c1)C(=O)O[C@@H](C)CCCC(=O)CCCCC2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008411_numbered.png,2026-03-19 06:56:53.394932
4304,ML00001322,CHEMBL1778045,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001322_numbered.png,2026-03-19 06:56:53.470847
4305,ML00000298,CHEMBL572996,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000298_numbered.png,2026-03-19 06:56:53.539076
4306,ML00009539,,,C=CCO[C@]1(C)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCN(C)C)C(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009539_numbered.png,2026-03-19 06:56:53.603042
4307,ML00006998,,,COc1cc(O)c2c(c1Br)C(=O)OCC(=O)NCC(=S)N[C@H](c1nc(CNC(C)C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4308,ML00007592,,,CCCCCCC[C@H]1CC(=O)N[C@@H](CO)C(=O)O[C@H](CCCCCCC)CC(=O)N[C@@H](CO)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4309,ML00002255,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NCc2ccc(-c3ccncn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002255_numbered.png,2026-03-19 06:56:53.689638
4310,ML00000844,CHEMBL2159140,,CC/N=C1\O[C@H]2[C@H](O[C@@H]3[C@@H](C)[C@H](O[C@H]4C[C@@](C)(OC)[C@@H](O)[C@H](C)O4)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]3(C)O)O[C@H](C)C[C@@H]2N1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000844_numbered.png,2026-03-19 06:56:53.770503
4311,ML00007394,,,COc1ccccc1C1CC(=O)Oc2cc3c(c(O)c21)C(=O)OC(C)CCCC(=O)CCCC=C3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007394_numbered.png,2026-03-19 06:56:53.802003
4312,ML00004221,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCNc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004221_numbered.png,2026-03-19 06:56:53.867629
4313,ML00008493,,,COc1cc(O)c2c(c1Br)C(=O)OCC(=O)NCC(=O)N[C@H](c1nc(C3CC3)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4314,ML00006639,,,COc1cc(O)c2c(c1Br)C(=O)O[C@H](c1ccccc1)C(=O)NCC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4315,ML00008430,,,CC(C)CC1NC(=O)C(C)NC(=O)C(CC(C)C)OC(=O)CCCNC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4316,ML00007943,,,CC1CC=CCCCCC(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007943_numbered.png,2026-03-19 06:56:53.913203
4317,ML00007002,,,C=C1/C=C(\C)[C@H](CC)OC(=O)[C@@H](C)C(=O)[C@@](O)(CO)C/C(OC)=C/[C@@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00007002_numbered.png,2026-03-19 06:56:53.967035
4318,ML00002179,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=C/c2ccnc3ccccc23)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002179_numbered.png,2026-03-19 06:56:54.035629
4319,ML00005838,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)N(C)NCCc2ccc(-c3cnccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005838_numbered.png,2026-03-19 06:56:54.104552
4320,ML00009442,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@H](OC)[C@@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@](C)(O)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 5, 6, 7, 8, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009442_numbered.png,2026-03-19 06:56:54.176508
4321,ML00007811,,,CC1CC2OC2C=CC=CC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007811_numbered.png,2026-03-19 06:56:54.205810
4322,ML00008230,,,C[C@H]1COC(=O)C/C=C\[C@@H](C)COC(=O)[C@H]2CCCN2C1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4323,ML00006066,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nc(-c4ccccc4)c(-c4ccccc4)o3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006066_numbered.png,2026-03-19 06:56:54.277211
4324,ML00003212,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#CCc2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003212_numbered.png,2026-03-19 06:56:54.338438
4325,ML00005830,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CC(C)(C)C[C@@H]2c2ccccc2Cl)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005830_numbered.png,2026-03-19 06:56:54.403168
4326,ML00003490,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccc([N+](=O)[O-])cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003490_numbered.png,2026-03-19 06:56:54.476063
4327,ML00003503,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccc2OC)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003503_numbered.png,2026-03-19 06:56:54.549077
4328,ML00003148,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCCCc2cncc3ccccc23)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003148_numbered.png,2026-03-19 06:56:54.611230
4329,ML00004332,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCOCc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004332_numbered.png,2026-03-19 06:56:54.672040
4330,ML00007736,,,C[C@@H]1C[C@H]2O[C@H]2CC/C=C\C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007736_numbered.png,2026-03-19 06:56:54.699283
4331,ML00001806,CHEMBL556492,,CO/N=C1/C=C/C=C\[C@H]2O[C@@H]2C[C@@H](C)OC(=O)c2c(O)cc(O)c(Cl)c2C1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00001806_numbered.png,2026-03-19 06:56:54.726067
4332,ML00007358,,,CCCCCCCCC[C@H](O)C[C@@H]1C[C@@H](O)C/C(C)=C\C/C=C\C/C(CC(=O)O)=C\C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 7, 13]",ring_size_14/standard/numbered/ML00007358_numbered.png,2026-03-19 06:56:54.758361
4333,ML00000103,CHEMBL405863,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2[C@H](SCCn3cnc4cccnc43)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000103_numbered.png,2026-03-19 06:56:54.821739
4334,ML00002165,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NN(C)CCc2ccc(-c3ncccn3)s2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002165_numbered.png,2026-03-19 06:56:54.882959
4335,ML00002243,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002243_numbered.png,2026-03-19 06:56:54.942398
4336,ML00002822,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4ccccc4)n3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002822_numbered.png,2026-03-19 06:56:54.999950
4337,ML00000242,CHEMBL313587,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)NC2CCCC2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000242_numbered.png,2026-03-19 06:56:55.027250
4338,ML00002531,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2ccc(-c3nnn(C)n3)s2)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002531_numbered.png,2026-03-19 06:56:55.084726
4339,ML00001639,CHEMBL380436,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](OC(=O)CC(=O)OCc3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001639_numbered.png,2026-03-19 06:56:55.158736
4340,ML00009012,,,COC1C[C@@H](O[C@@H]2C(C)C(=O)OC(C)C(C)C(O)C(C)C(=O)[C@@]3(CO3)CC(C)C(OC3OC(C)CC(N(C)C)C3O)C2C)OC(C)[C@@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009012_numbered.png,2026-03-19 06:56:55.223708
4341,ML00004253,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)c2ccc([N+](=O)[O-])cc2N)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004253_numbered.png,2026-03-19 06:56:55.310339
4342,ML00009208,,,CC[C@H]1OC(=O)[C@H](C)C[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00009208_numbered.png,2026-03-19 06:56:55.367598
4343,ML00002498,,,CC(=O)OC[C@@]12[C@H](O)[C@@H](OC(C)=O)[C@H]3[C@H](OC(C)=O)[C@]14O[C@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@@H](C)C(=O)O[C@@H]([C@@H](OC(=O)c1ccc(=O)n(C)c1)[C@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4344,ML00006963,,,CC[C@@H]1OC(=O)[C@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C[C@H](C)C(=O)/C=C\[C@@H]1C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006963_numbered.png,2026-03-19 06:56:55.425700
4345,ML00004257,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccccc3N)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004257_numbered.png,2026-03-19 06:56:55.479076
4346,ML00003565,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3ccc([N+](=O)[O-])cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003565_numbered.png,2026-03-19 06:56:55.532297
4347,ML00001717,CHEMBL3898203,,C[C@@H]1OC(=O)c2c(O)cc(NOC[C@H](O)CO)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001717_numbered.png,2026-03-19 06:56:55.565961
4348,ML00000208,CHEMBL3736314,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3cccc(-c4cn(CCCCCCC(=O)NO)nn4)c3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000208_numbered.png,2026-03-19 06:56:55.618835
4349,ML00000737,CHEMBL92538,,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CNC(=O)CCCCOC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4350,ML00003624,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)/C(=N\O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003624_numbered.png,2026-03-19 06:56:55.687264
4351,ML00003807,,,C=CCO[C@@]1(C)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003807_numbered.png,2026-03-19 06:56:55.757583
4352,ML00008090,,,C[C@@H]1CCC/C=C\[C@H](O)/C=C\[C@H](O)/C=C\C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 9, 12]",ring_size_14/standard/numbered/ML00008090_numbered.png,2026-03-19 06:56:55.786855
4353,ML00006223,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC2CCCN(C/C=C\c3ccc(-c4ccccc4)cc3)C2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006223_numbered.png,2026-03-19 06:56:55.851462
4354,ML00006018,,,CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H]2[C@@H](OC(C)=O)[C@@]34O[C@@]2(C)COC(=O)c2cccnc2[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c2ccc(=O)n(C)c2)[C@H](OC(C)=O)[C@@]13COC(=O)C(C)C)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4355,ML00003665,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2OC(=O)N3C)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003665_numbered.png,2026-03-19 06:56:55.926770
4356,ML00006624,,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OC(=O)N2CCCCC2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00006624_numbered.png,2026-03-19 06:56:55.953775
4357,ML00002241,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cccc3cnccc23)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002241_numbered.png,2026-03-19 06:56:56.011794
4358,ML00004639,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004639_numbered.png,2026-03-19 06:56:56.070875
4359,ML00009011,,,CO[C@@H]1C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@H]3O[C@@H](C)C[C@@H](N(C)C)[C@@H]3O)[C@](C)(O)C[C@@]3(CO3)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)O[C@H](C)[C@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009011_numbered.png,2026-03-19 06:56:56.130598
4360,ML00002447,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccc2[N+](=O)[O-])[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002447_numbered.png,2026-03-19 06:56:56.195391
4361,ML00004830,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(-c5ccc(Br)cc5)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004830_numbered.png,2026-03-19 06:56:56.261503
4362,ML00007978,,,C/C1=C/CC[C@H](C)[C@@H](C)OC(=O)/C=C\[C@](C)(O)/C=C\C1=O,standard_macrolactone,14.0,,,success,,6.0,"[3, 4, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00007978_numbered.png,2026-03-19 06:56:56.298707
4363,ML00000251,CHEMBL84714,,COC(=O)CNC(=O)CO/N=C1\C=C\C=C/[C@H]2O[C@@H]2C[C@@H](C)OC(=O)c2c(O)cc(O)c(Cl)c2C1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000251_numbered.png,2026-03-19 06:56:56.323629
4364,ML00009652,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@H]4C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4365,ML00002642,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCN(C)c3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00002642_numbered.png,2026-03-19 06:56:56.382570
4366,ML00000594,CHEMBL1514023,,C[C@H]1COC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)COC(=O)[C@H](Cc2ccccc2)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4367,ML00002627,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccc(OC)c(OC)c2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002627_numbered.png,2026-03-19 06:56:56.451490
4368,ML00006402,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CC2CCCCC2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006402_numbered.png,2026-03-19 06:56:56.517552
4369,ML00001583,CHEMBL3736113,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCC(=O)NO)nn4)cc3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001583_numbered.png,2026-03-19 06:56:56.571922
4370,ML00005944,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCc3ccnc4ccc(OC)cc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005944_numbered.png,2026-03-19 06:56:56.628615
4371,ML00001798,CHEMBL3357680,,C[C@H]1/C=C\C[C@@H]2[C@@H](O)CC[C@H]2CC(=O)OC[C@H]2O[C@@H](O1)[C@H](O)[C@@H](O)[C@@H]2O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4372,ML00003166,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=C\C=C\c3ccc(F)cc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003166_numbered.png,2026-03-19 06:56:56.691200
4373,ML00006511,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1C(C)C(C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4374,ML00006731,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3c(Cl)cccc3Cl)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00006731_numbered.png,2026-03-19 06:56:56.724107
4375,ML00008505,,,COc1cc(O)c2c(c1OC)/C=C\CCC(=O)[C@@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00008505_numbered.png,2026-03-19 06:56:56.751475
4376,ML00002888,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NCc2ccc(-c3ccccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2CC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002888_numbered.png,2026-03-19 06:56:56.808103
4377,ML00007447,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1cccnc1)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007447_numbered.png,2026-03-19 06:56:56.833448
4378,ML00009115,,,C=C1CO[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(C[C@@H](C)[C@H](N)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)OC1,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 5, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00009115_numbered.png,2026-03-19 06:56:56.895169
4379,ML00000166,CHEMBL1801948,,C[C@H]1C/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00000166_numbered.png,2026-03-19 06:56:56.927370
4380,ML00007497,,,COc1cc2c(c(OCC(O)CNC(C)C)c1)C(=O)OC(C)CCCC(=O)CCCC=C2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007497_numbered.png,2026-03-19 06:56:56.951537
4381,ML00001231,CHEMBL2047340,ILICIFOLIUNINE A,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4382,ML00004756,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2ccc(F)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004756_numbered.png,2026-03-19 06:56:57.021614
4383,ML00007119,,,COc1cc(O)c2c(c1)/C=C\C[C@H](O)[C@@H]1OC(C)(C)O[C@H]1/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 9]",ring_size_14/standard/numbered/ML00007119_numbered.png,2026-03-19 06:56:57.048235
4384,ML00000306,CHEMBL1357195,,CO[C@H]1C[C@@H](O[C@H]2[C@@H](C)C(=O)O[C@@H](C)[C@@H](C)[C@@H](O)[C@@H](C)C(=O)[C@@]3(CO3)C[C@@H](C)[C@@H](O[C@@H]3O[C@@H](C)C[C@@H](N(C)C)[C@@H]3O)[C@H]2C)O[C@@H](C)[C@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000306_numbered.png,2026-03-19 06:56:57.103321
4385,ML00006358,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCc3ccc(-c4ccccc4)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006358_numbered.png,2026-03-19 06:56:57.159944
4386,ML00009620,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCc2ccco2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009620_numbered.png,2026-03-19 06:56:57.224458
4387,ML00007729,,,C[C@@H]1C[C@@H](O)[C@@H](Cl)/C=C\C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 6, 11]",ring_size_14/standard/numbered/ML00007729_numbered.png,2026-03-19 06:56:57.255749
4388,ML00000935,CHEMBL275251,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCOCC2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000935_numbered.png,2026-03-19 06:56:57.313489
4389,ML00003003,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4390,ML00007567,,,CO[C@@H]1OC2=C(C3=C1C(=O)CC3)[C@@]1(Cc3ccc(cc3)Oc3cc(ccc3O)CCOC1=O)OC2=O,non_standard_macrocycle,14.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
4391,ML00007385,,,COC(C[C@H]1OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC[C@H]1O)C(C)Cc1csc(C)n1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 8, 9, 10, 11, 12, 12, 13]",ring_size_14/standard/numbered/ML00007385_numbered.png,2026-03-19 06:56:57.374623
4392,ML00002886,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc3ncccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2CC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002886_numbered.png,2026-03-19 06:56:57.431314
4393,ML00002271,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cncc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002271_numbered.png,2026-03-19 06:56:57.494143
4394,ML00003482,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003482_numbered.png,2026-03-19 06:56:57.549983
4395,ML00007893,,,C[C@@H]1C[C@@H](O)[C@@H](O)CCCCC(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 6, 11]",ring_size_14/standard/numbered/ML00007893_numbered.png,2026-03-19 06:56:57.581124
4396,ML00001062,CHEMBL3919867,,C[C@H]1CCC[C@@H](O)/C=C/C=C\[C@H](O)/C=C/C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 12]",ring_size_14/standard/numbered/ML00001062_numbered.png,2026-03-19 06:56:57.608145
4397,ML00001408,CHEMBL1256542,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001408_numbered.png,2026-03-19 06:56:57.671069
4398,ML00004328,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3cccc([N+](=O)[O-])c3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004328_numbered.png,2026-03-19 06:56:57.734647
4399,ML00006787,,,COc1cc(OC(C)=O)c2c(c1)[C@H]1O[C@@H]1C[C@H](OC(C)=O)[C@H](OC(C)=O)C(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00006787_numbered.png,2026-03-19 06:56:57.767993
4400,ML00002119,CHEMBL3577611,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O)[C@](C)(O)C[C@@H](C)/C(=N\OCc2cn(CCNC(=N)NC(=O)NC)nn2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002119_numbered.png,2026-03-19 06:56:57.827683
4401,ML00004364,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)(CN(C)Cc3ccc(-c4cn(CCCCC(=O)NO)nn4)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(OC)CC(C)C(=O)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004364_numbered.png,2026-03-19 06:56:57.893066
4402,ML00007414,,,CC[C@H](/C=C(/C)[C@@H]1C[C@@H](OC)C[C@H](O)C(C)(C)[C@@]2(O)O[C@@H](C[C@@H](OC)[C@H](O)C(=O)O1)C[C@@H](OC)[C@H]2O)CO,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4403,ML00004326,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004326_numbered.png,2026-03-19 06:56:57.953453
4404,ML00010576,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)C12C=NNC2,standard_macrolactone,14.0,,,success,,11.0,"[3, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010576_numbered.png,2026-03-19 06:56:58.009082
4405,ML00007425,,,CC1=C[C@@H](C)[C@@H]2[C@H](C=C[C@@H]3[C@H]2C(=O)C(Cl)(Cl)C(=O)[C@H](C)C(=O)O[C@@H](C)/C=C\C=C/[C@H]3C)C1,standard_macrolactone,14.0,,,success,,7.0,"[3, 8, 11, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00007425_numbered.png,2026-03-19 06:56:58.050481
4406,ML00002001,CHEMBL3577619,,C#CCO[C@@H]1[C@@H](C)[C@H](OC(=O)NCCNC(=N)NC(=O)NC)[C@@H](C)C(=O)O[C@H](CC)C(C)(C)[C@@H]2OC(C)(C)O[C@H]([C@@H]2C)[C@H](C)C[C@@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002001_numbered.png,2026-03-19 06:56:58.105779
4407,ML00007343,,,COc1cc2c(c(OC)c1)C(=O)OC(C)CCCC(NCCc1ccccc1)CCCC=C2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007343_numbered.png,2026-03-19 06:56:58.131155
4408,ML00002395,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCCc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002395_numbered.png,2026-03-19 06:56:58.185707
4409,ML00008096,,,C[C@@H]1CC[C@@H](O)/C=C\C(=O)O[C@H](C)C(=O)/C=C\C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4410,ML00009619,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O/C=C\Cc2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009619_numbered.png,2026-03-19 06:56:58.255062
4411,ML00006260,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006260_numbered.png,2026-03-19 06:56:58.322474
4412,ML00002890,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3cccnn3)cc2)C[C@@H](C)/C(=N\O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002890_numbered.png,2026-03-19 06:56:58.385491
4413,ML00001841,CHEMBL559732,,C[C@@H]1C[C@@H](O)[C@@H](O)/C=C\C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 6, 11]",ring_size_14/standard/numbered/ML00001841_numbered.png,2026-03-19 06:56:58.417834
4414,ML00001349,CHEMBL3577621,,C#CCO[C@@H]1[C@@H](C)[C@H](OC(=O)NCCCCCNC(=N)NC(=O)NC)[C@@H](C)C(=O)O[C@H](CC)C(C)(C)[C@@H]2OC(C)(C)O[C@H]([C@@H]2C)[C@H](C)C[C@@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001349_numbered.png,2026-03-19 06:56:58.473696
4415,ML00009002,,,C=C1C[C@H](C)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@H](OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)[C@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009002_numbered.png,2026-03-19 06:56:58.532157
4416,ML00006661,,,C[C@H]1C/C=C\CC/C=C\C(=O)Cc2cc(O[C@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00006661_numbered.png,2026-03-19 06:56:58.558191
4417,ML00001554,CHEMBL572998,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCc2ccc(C(=O)NC)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001554_numbered.png,2026-03-19 06:56:58.622566
4418,ML00002904,,,CCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@](C)(O)[C@H](OC(=O)CC)[C@@H](C)C(=O)[C@H](C)C[C@]2(C)O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002904_numbered.png,2026-03-19 06:56:58.687254
4419,ML00007467,,,CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)/C=C/c2ccc(O)cc2)[C@@H](C)OC(=O)[C@@H](C)CNC(=O)[C@@H](C)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4420,ML00002044,CHEMBL3680941,,COc1ccc2c(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)NS(=O)(=O)C6CC6)C[C@H]5/C=C\CCCCOC(=O)N4C3)nc(Cl)cc2c1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4421,ML00002648,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)c2ccc(C)cc2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002648_numbered.png,2026-03-19 06:56:58.762746
4422,ML00001409,CHEMBL1778047,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001409_numbered.png,2026-03-19 06:56:58.828777
4423,ML00007655,,,C/C1=C/[C@@H](C)[C@H](O)C/C=C/CC/C=C/C(=O)O[C@@H]1[C@H](C)C(=O)CCCC1CC(=O)NC(=O)C1,standard_macrolactone,14.0,,,success,,4.0,"[3, 4, 6, 7]",ring_size_14/standard/numbered/ML00007655_numbered.png,2026-03-19 06:56:58.861164
4424,ML00005534,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)CCNC(=O)OC(C)(C)C)[C@@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005534_numbered.png,2026-03-19 06:56:58.926100
4425,ML00007407,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1ccc(C(=O)O)cc1)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007407_numbered.png,2026-03-19 06:56:58.952425
4426,ML00007057,,,CC[C@H](C)[C@]1(O)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](O)(CC)[C@@H](C)OC(=O)[C@@H]1O)[C@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4427,ML00009061,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C=C/CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009061_numbered.png,2026-03-19 06:56:59.014616
4428,ML00008776,,,CC[C@@H]1OC(=O)CCCC/C=C\C/C=C\[C@H]2[C@H]1C[C@@H](O)[C@@H]2O,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008776_numbered.png,2026-03-19 06:56:59.037095
4429,ML00009613,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O/C=C\Cc2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009613_numbered.png,2026-03-19 06:56:59.100158
4430,ML00002128,CHEMBL85583,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)N2CCC(N3CCCCC3)CC2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00002128_numbered.png,2026-03-19 06:56:59.127071
4431,ML00004751,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N(C)c2ccncc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004751_numbered.png,2026-03-19 06:56:59.185934
4432,ML00002809,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)N[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002809_numbered.png,2026-03-19 06:56:59.241399
4433,ML00008109,,,CC1COC(=O)CCCCCCCCC(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4434,ML00009019,,,COC1CC(OC2C(C)C(=O)OC(C)C(C)C(O)C(C)C(=O)C3(CO3)CC(C)C(OC3OC(C)CC(N(C)C)C3O)C2C)OC(C)C1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009019_numbered.png,2026-03-19 06:56:59.300064
4435,ML00006932,,,C[C@@H]1OC(=O)c2c(O)cc(NCCOP(=O)(O)O)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00006932_numbered.png,2026-03-19 06:56:59.335259
4436,ML00006430,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@@H](n2ccc(O)c2C(=O)OC(C)(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006430_numbered.png,2026-03-19 06:56:59.402643
4437,ML00003869,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=N/OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003869_numbered.png,2026-03-19 06:56:59.468499
4438,ML00000441,CHEMBL275935,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C3CCCC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000441_numbered.png,2026-03-19 06:56:59.528001
4439,ML00008344,,,COc1cc(O)c2c(c1)CCCCCC(=O)C=CC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008344_numbered.png,2026-03-19 06:56:59.552577
4440,ML00004733,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3ccc(-c4cn(CCCC(=O)NO)nn4)cc3)C2O)C(C)(OC)CC(C)C(=O)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004733_numbered.png,2026-03-19 06:56:59.616939
4441,ML00006417,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006417_numbered.png,2026-03-19 06:56:59.683758
4442,ML00005852,,,C=C[C@]12OC(=O)N(CCCCn3cnc(-c4ccc(Cl)nc4)c3)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005852_numbered.png,2026-03-19 06:56:59.741092
4443,ML00006739,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3ccccc3Cl)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00006739_numbered.png,2026-03-19 06:56:59.766084
4444,ML00002168,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCc1ccc(-c2cncnc2)s1,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002168_numbered.png,2026-03-19 06:56:59.818708
4445,ML00002224,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(=O)[C@H](C)[C@H](C)c4ncccc4C(=O)OC[C@@]4(C)O[C@@]1([C@H]3C)[C@@H](OC(C)=O)[C@@H]4[C@H](OC(=O)c1cccnc1)[C@@H]2OC(C)=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4446,ML00001876,CHEMBL4082892,,C=C1CCC[C@H](C)OC(=O)c2c(O)cc(OC)cc2CCC[C@H](O)[C@@H]1O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001876_numbered.png,2026-03-19 06:56:59.856545
4447,ML00001837,CHEMBL561866,,C[C@@H]1C[C@H]2S[C@@H]2/C=C\C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00001837_numbered.png,2026-03-19 06:56:59.881033
4448,ML00008358,,,COc1cc(O)c(Cl)c2c1C(=O)O[C@@H](C)CC[C@@H](O)CC/C=C\C(=O)C2,standard_macrolactone,14.0,,,success,,3.0,"[3, 6, 11]",ring_size_14/standard/numbered/ML00008358_numbered.png,2026-03-19 06:56:59.908079
4449,ML00007438,,,Cc1ccccc1COc1cc(O)c2c(c1)C=CCCCC(=O)CCCC(C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007438_numbered.png,2026-03-19 06:56:59.932190
4450,ML00005780,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccc[nH]2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005780_numbered.png,2026-03-19 06:56:59.994915
4451,ML00010220,,,C[C@H]1C[C@@H](C)C(=O)/C=C\[C@@H](C)[C@@H]([C@@H](C)O)OC(=O)[C@H](C)C(=O)[C@H](C)[C@H]1O[C@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010220_numbered.png,2026-03-19 06:57:00.043813
4452,ML00002762,,,C=C[C@]12OC(=O)N(CCCCn3cnc(-c4cncnc4)c3)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002762_numbered.png,2026-03-19 06:57:00.100988
4453,ML00004165,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)[C@@H](N(C)C)[C@H](C)[C@@H](O)[C@H]1CO,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004165_numbered.png,2026-03-19 06:57:00.163290
4454,ML00000266,CHEMBL311607,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)Nc2ccccc2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000266_numbered.png,2026-03-19 06:57:00.189285
4455,ML00003109,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cnc3ccccc3c2)[C@H](C)[C@@H]2OC(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003109_numbered.png,2026-03-19 06:57:00.245277
4456,ML00010588,,,COc1c2c(cc3c1C(c1ccc(-c4ccccc4)o1)CC(=O)O3)C=CCCCC(=O)CCCC(C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010588_numbered.png,2026-03-19 06:57:00.270998
4457,ML00008475,,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C(/C)C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 5, 7, 8, 9]",ring_size_14/standard/numbered/ML00008475_numbered.png,2026-03-19 06:57:00.304402
4458,ML00004229,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)c2cccc(O)c2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004229_numbered.png,2026-03-19 06:57:00.365766
4459,ML00001295,CHEMBL126115,,CC(C)(C)CC(=O)NCCOC(=O)NC(Cc1ccccc1)C(=O)N[C@H]1COC(=O)CCC[C@H](CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4460,ML00007593,,,O=C(C[C@@H]1C/C=C/CCCCC(=O)O[C@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4461,ML00001815,CHEMBL2012382,,C[C@@H]1C/C=C/[C@@H](O)[C@@H](O)CC/C=C/c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00001815_numbered.png,2026-03-19 06:57:00.406537
4462,ML00006183,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cnc3ccccc3c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006183_numbered.png,2026-03-19 06:57:00.468023
4463,ML00008712,,,COc1cc(O)c2c(c1)[C@H](O)[C@H](O)C[C@H]1O[C@@H]1C(=O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 11, 12]",ring_size_14/standard/numbered/ML00008712_numbered.png,2026-03-19 06:57:00.500319
4464,ML00010230,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010230_numbered.png,2026-03-19 06:57:00.548724
4465,ML00010736,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CN)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)C2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010736_numbered.png,2026-03-19 06:57:00.612112
4466,ML00009451,,,CC[C@@H]1OC(=O)[C@@H](C)[C@@H](O[C@@H]2C[C@H](OC)[C@@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@@H](C)[C@@H](O)[C@@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009451_numbered.png,2026-03-19 06:57:00.676750
4467,ML00000018,CHEMBL1077979,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00000018_numbered.png,2026-03-19 06:57:00.708465
4468,ML00006559,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC(O)CNCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006559_numbered.png,2026-03-19 06:57:00.772862
4469,ML00006227,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc5cccnc54)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006227_numbered.png,2026-03-19 06:57:00.833641
4470,ML00002791,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cc(-c4cccc(N)c4)nn3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002791_numbered.png,2026-03-19 06:57:00.896277
4471,ML00001466,CHEMBL384920,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C3CCCCC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001466_numbered.png,2026-03-19 06:57:00.957487
4472,ML00005727,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2cncc(N)c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005727_numbered.png,2026-03-19 06:57:01.018335
4473,ML00001842,CHEMBL3827720,,C[C@H]1CCCC(=O)CCC/C=C/c2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00001842_numbered.png,2026-03-19 06:57:01.044398
4474,ML00005611,,,CC(=O)OCC12C(OC(C)=O)C(O)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)OC(C(OC(=O)c1ccc(=O)n(C)c1)C2OC(=O)c1ccccc1)C4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4475,ML00003219,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2ccc(-c3ccccn3)s2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003219_numbered.png,2026-03-19 06:57:01.112140
4476,ML00006900,,,C=C1/C=C(/C)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@@](O)(CO)C/C(C)=C\[C@@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00006900_numbered.png,2026-03-19 06:57:01.160299
4477,ML00008177,,,O=C1Cc2ccc(cc2)Oc2cc(ccc2O)CCOC1=O,non_standard_macrocycle,14.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
4478,ML00004125,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#CCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004125_numbered.png,2026-03-19 06:57:01.225549
4479,ML00006561,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCCNCCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006561_numbered.png,2026-03-19 06:57:01.291407
4480,ML00002861,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2cncc(-c3ccccn3)c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002861_numbered.png,2026-03-19 06:57:01.353171
4481,ML00000159,CHEMBL1668416,,COc1cc(O)c2c(c1)/C=C\CCCC(=O)C[C@H](Cl)C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 5, 7]",ring_size_14/standard/numbered/ML00000159_numbered.png,2026-03-19 06:57:01.381343
4482,ML00003133,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc3nccnc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2CC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003133_numbered.png,2026-03-19 06:57:01.437777
4483,ML00002268,,,CC(=O)OC[C@@]12[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(=O)[C@@H](C)[C@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@]1([C@H](OC(C)=O)[C@@H]4[C@@H](OC(C)=O)[C@@H]2OC(=O)C(C)(C)OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4484,ML00008542,,,CC[C@H]1OC(=O)CCCC/C=C\C/C=C\[C@H]2[C@H](O)[C@@H](Cl)C[C@H]12,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008542_numbered.png,2026-03-19 06:57:01.467463
4485,ML00004420,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC(=O)C(Cc3ccc(O)cc3)NC(=O)CCCOc3ccc([N+](=O)[O-])cc3OC)[C@H]2O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004420_numbered.png,2026-03-19 06:57:01.534854
4486,ML00003808,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC2CO2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003808_numbered.png,2026-03-19 06:57:01.602372
4487,ML00003514,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCc2ccc(F)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003514_numbered.png,2026-03-19 06:57:01.668224
4488,ML00001814,CHEMBL3629244,,COc1cc(O)c2c(c1)[C@H]1O[C@@H]1C[C@H](O)[C@H](O)C(=O)/C=C/C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001814_numbered.png,2026-03-19 06:57:01.700372
4489,ML00002628,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCCc2ccc(OC)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002628_numbered.png,2026-03-19 06:57:01.766390
4490,ML00001789,CHEMBL557309,,C[C@@H]1C[C@H]2O[C@@H]2CC/C=C/[C@H](O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00001789_numbered.png,2026-03-19 06:57:01.793600
4491,ML00003302,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(F)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003302_numbered.png,2026-03-19 06:57:01.850127
4492,ML00004355,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)c2ccc(Br)cc2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004355_numbered.png,2026-03-19 06:57:01.917146
4493,ML00003521,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nccc(C)n3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003521_numbered.png,2026-03-19 06:57:01.977423
4494,ML00002162,,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)N/C=C/c2ccc(-n3ccnc3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002162_numbered.png,2026-03-19 06:57:02.038116
4495,ML00004494,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)CCNC(=O)OC(C)(C)C)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)CCNC(=O)OC(C)(C)C)[C@@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004494_numbered.png,2026-03-19 06:57:02.106931
4496,ML00009113,,,CC[C@H]1OC(=O)[C@H](C)C2O[C@@](C)(C[C@@H](C)CN(C(=O)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4497,ML00005413,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](C)[C@@H](OCc4ccccc4)[C@H](N(C)C)[C@H]3OC(=O)c3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005413_numbered.png,2026-03-19 06:57:02.199861
4498,ML00004223,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3cccc(O)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004223_numbered.png,2026-03-19 06:57:02.255150
4499,ML00007102,,,C=C1/C=C(/CO)[C@H](CC)OC(=O)[C@H](C)C(=O)[C@](O)(CO)C/C(OC)=C\[C@@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00007102_numbered.png,2026-03-19 06:57:02.305577
4500,ML00005493,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCOCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005493_numbered.png,2026-03-19 06:57:02.372561
4501,ML00010187,,,COc1c2c(cc3c1C(c1ccc4c(c1)OCCO4)CC(=O)O3)C=CCCCC(=O)CCCC(C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010187_numbered.png,2026-03-19 06:57:02.399404
4502,ML00004185,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](N(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004185_numbered.png,2026-03-19 06:57:02.464223
4503,ML00005909,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCC#Cc2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2Cl)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005909_numbered.png,2026-03-19 06:57:02.523369
4504,ML00004217,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3cccc(C(F)(F)F)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004217_numbered.png,2026-03-19 06:57:02.577884
4505,ML00010208,,,CCCCCC/C=C/C[C@@H]1CC(=O)N[C@@H](CO)C(=O)O[C@@H](CCCCCCC)CC(=O)N[C@@H](CO)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4506,ML00000421,CHEMBL3735736,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000421_numbered.png,2026-03-19 06:57:02.636504
4507,ML00003878,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003878_numbered.png,2026-03-19 06:57:02.701442
4508,ML00003028,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4509,ML00006274,,,CCC(=O)O[C@H]1[C@H](C)OC(O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc3ccccc3)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006274_numbered.png,2026-03-19 06:57:02.774719
4510,ML00007716,,,COc1cc(O)c2c(c1Br)C(=O)OCC(=O)NCC(=O)N[C@H](c1nc(CO)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4511,ML00009159,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC[C@@H](N)C(=O)O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009159_numbered.png,2026-03-19 06:57:02.843433
4512,ML00007133,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)C[C@@](O)(CO)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00007133_numbered.png,2026-03-19 06:57:02.900235
4513,ML00000929,CHEMBL430312,,CCC1CN(C(=O)O[C@H]2[C@H](C)[C@@H](OC3O[C@H](C)C[C@H](N(C)C(C)C)[C@H]3O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]3N(CCc4ccc(Cl)cc4)C(=O)O[C@]3(C)[C@@H](CC)OC(=O)[C@@H]2C)C(=O)O1,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000929_numbered.png,2026-03-19 06:57:02.958208
4514,ML00003802,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C3CCC3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003802_numbered.png,2026-03-19 06:57:03.019426
4515,ML00003230,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2cncc3ccccc23)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00003230_numbered.png,2026-03-19 06:57:03.079769
4516,ML00003223,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2cncc3ccccc23)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003223_numbered.png,2026-03-19 06:57:03.137217
4517,ML00003040,,,CO[C@H]1C[C@@H](C)O[C@@H](O[C@H]2[C@@H](C)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(C)=O)[C@@H](C)[C@@H]([C@@H](C)[C@H](C)O)OC(=O)[C@H](C)[C@@H](O[C@H]3C[C@@](C)(OC)[C@H](OC(C)=O)[C@H](C)O3)[C@@H]2C)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003040_numbered.png,2026-03-19 06:57:03.199439
4518,ML00005280,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNCCOc2ccccc2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005280_numbered.png,2026-03-19 06:57:03.266390
4519,ML00004096,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(=O)c1cccnc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4520,ML00002202,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2ccc3ncccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002202_numbered.png,2026-03-19 06:57:03.330496
4521,ML00010794,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1cc2ccccc2n(C)c1=O)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010794_numbered.png,2026-03-19 06:57:03.356044
4522,ML00008047,,,C[C@H]1CCC/C=C\[C@H](O)[C@H]2O[C@H]2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 9, 12]",ring_size_14/standard/numbered/ML00008047_numbered.png,2026-03-19 06:57:03.383781
4523,ML00006733,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3ccc(Br)cc3)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00006733_numbered.png,2026-03-19 06:57:03.407455
4524,ML00006583,,,CCCCCNC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006583_numbered.png,2026-03-19 06:57:03.469581
4525,ML00004458,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3ccc4c(=O)c(C(=O)O)cn(C)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004458_numbered.png,2026-03-19 06:57:03.535033
4526,ML00003161,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCc1cnc2ccccc2c1,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003161_numbered.png,2026-03-19 06:57:03.587783
4527,ML00003047,,,CO[C@H]1C[C@H](C)O[C@H](O[C@H]2[C@@H](C)C[C@](C)(O)C(=O)[C@H](C)[C@@H](OC(C)=O)[C@@H](C)[C@@H]([C@@H](C)[C@H](C)O)OC(=O)[C@H](C)[C@@H](O[C@@H]3C[C@@](C)(OC)[C@@H](OC(C)=O)[C@@H](C)O3)[C@@H]2C)[C@@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003047_numbered.png,2026-03-19 06:57:03.650541
4528,ML00010600,,,COc1c2c(cc3c1C(c1cc4ccccc4n(C)c1=O)CC(=O)O3)C=CCCCC(=O)CCCC(C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010600_numbered.png,2026-03-19 06:57:03.676814
4529,ML00005878,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4ccccc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005878_numbered.png,2026-03-19 06:57:03.732145
4530,ML00008791,,,CC[C@@H]1OC(=O)CCCCCCC/C=C\[C@H]2[C@H]1C[C@@H](O)[C@@H]2O,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008791_numbered.png,2026-03-19 06:57:03.754487
4531,ML00008737,,,CO[C@H]1/C=C\C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O[C@@H](C)C[C@@H]1O,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 6, 11]",ring_size_14/standard/numbered/ML00008737_numbered.png,2026-03-19 06:57:03.785432
4532,ML00008550,,,C[C@H]1CCC[C@H](O)CCCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008550_numbered.png,2026-03-19 06:57:03.810044
4533,ML00002591,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NCCCSC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002591_numbered.png,2026-03-19 06:57:03.873917
4534,ML00001069,CHEMBL3828436,,CCC(=O)Oc1cc(O)c2c(c1)/C=C/CCCC(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00001069_numbered.png,2026-03-19 06:57:03.899220
4535,ML00000156,CHEMBL1399925,,CC1CCC[C@H](O)CCCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00000156_numbered.png,2026-03-19 06:57:03.923558
4536,ML00010221,,,CC[C@@H]1OC(=O)[C@H](C)C(=O)[C@@H](C)[C@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@H](C)C(=O)/C=C\[C@@]1(C)O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010221_numbered.png,2026-03-19 06:57:03.976283
4537,ML00002801,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@]2(C)N(CCCCSc3nc4ccc(OC)nc4[nH]3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002801_numbered.png,2026-03-19 06:57:04.036287
4538,ML00000589,CHEMBL3827737,,CCCCCCCCOc1cc(O)c2c(c1)/C=C/CCC[C@@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00000589_numbered.png,2026-03-19 06:57:04.060700
4539,ML00010769,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1ccc(-c2ccccc2)o1)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010769_numbered.png,2026-03-19 06:57:04.086201
4540,ML00003998,,,CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H]2[C@@H](OC(C)=O)[C@@]34O[C@@]2(C)COC(=O)c2cnccc2[C@@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]13COC(=O)c1ccco1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4541,ML00008879,,,COc1ccc(C[C@H]2NC(=O)C[C@@H](C[C@H](O)[C@H](C)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4542,ML00006199,,,CCCCNC(=O)CCCCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006199_numbered.png,2026-03-19 06:57:04.166989
4543,ML00003826,,,CCCN1C(=O)O[C@H]2[C@H](O[C@@H]3[C@@H](C)[C@H](O[C@H]4C[C@@](C)(OC)[C@@H](O)[C@H](C)O4)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]3(C)OC)O[C@H](C)C[C@@H]21,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003826_numbered.png,2026-03-19 06:57:04.232606
4544,ML00004321,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](O)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2cnc(C3CC3)nc2)C[C@@H](C)C(=O)[C@H](C)[C@@H]2NC(=S)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004321_numbered.png,2026-03-19 06:57:04.289936
4545,ML00001272,CHEMBL583090,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4ccnc5cccnc45)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001272_numbered.png,2026-03-19 06:57:04.346389
4546,ML00002211,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=C/c2ccc3ncccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002211_numbered.png,2026-03-19 06:57:04.403374
4547,ML00005875,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3ccc(N(C)C)c4ccccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00005875_numbered.png,2026-03-19 06:57:04.456679
4548,ML00002197,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCn1cnc(-c2ccc(F)nc2)c1,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002197_numbered.png,2026-03-19 06:57:04.510582
4549,ML00008479,,,COc1cc(O)c2c(c1OC)/C=C\C[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008479_numbered.png,2026-03-19 06:57:04.542419
4550,ML00006301,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006301_numbered.png,2026-03-19 06:57:04.601065
4551,ML00004469,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(-c5ccc(OC)cc5)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004469_numbered.png,2026-03-19 06:57:04.667553
4552,ML00005227,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNCCCCc2ccccc2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005227_numbered.png,2026-03-19 06:57:04.735207
4553,ML00008007,,,C[C@@H]1CC[C@@H](O)/C=C\C(=O)O[C@H](C)[C@@H](O)/C=C\C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4554,ML00009567,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CNC(=O)OC(C)(C)C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)C2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009567_numbered.png,2026-03-19 06:57:04.805125
4555,ML00007013,,,C=C1/C=C(\C)[C@H](CC)OC(=O)[C@H](C)C(=O)[C@@](O)(CO)C/C(OCC(F)(F)F)=C/[C@@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00007013_numbered.png,2026-03-19 06:57:04.852660
4556,ML00005371,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)CCC(=O)NCCCCCC(=O)NCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)[C@](C)(O)C[C@@H](C)C(NOCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005371_numbered.png,2026-03-19 06:57:04.920169
4557,ML00004115,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccccc2)C[C@@H](C)/C(=N\O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00004115_numbered.png,2026-03-19 06:57:04.980711
4558,ML00004580,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNCc2ccccn2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004580_numbered.png,2026-03-19 06:57:05.047884
4559,ML00007711,,,C[C@H]1C[C@H]2O[C@@H]2CCC=CC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007711_numbered.png,2026-03-19 06:57:05.074254
4560,ML00008681,,,COc1cc(O)c2c(c1Cl)CC(=O)/C=C/C=C\[C@H]1O[C@@H]1C[C@@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00008681_numbered.png,2026-03-19 06:57:05.099326
4561,ML00005865,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CC(C)(C)C[C@@H]2c2ccc(Cl)c(Cl)c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005865_numbered.png,2026-03-19 06:57:05.158366
4562,ML00003990,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1C(C)C(C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccco1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4563,ML00005380,,,CCOC(=O)c1cn(C2CC2)c2ccc(C#CCN3CCN(CCC(=O)O[C@H]4[C@H](C)O[C@@H](O[C@H]5[C@H](C)[C@@H](O[C@@H]6O[C@H](C)C[C@H](N(C)C)[C@H]6O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]5C)C[C@@]4(C)OC)CC3)cc2c1=O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005380_numbered.png,2026-03-19 06:57:05.233231
4564,ML00003284,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(O)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003284_numbered.png,2026-03-19 06:57:05.290832
4565,ML00002876,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC/C(=N\Oc3ccc4ccccc4c3)CCO[C@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]3NC(=O)O[C@]13C)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00002876_numbered.png,2026-03-19 06:57:05.346910
4566,ML00001341,CHEMBL338366,,CC(C)(C)S(=O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)CCC[C@H](CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4567,ML00002838,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2cnc3c(F)cccc3c2)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002838_numbered.png,2026-03-19 06:57:05.422695
4568,ML00010968,,,CO[C@@H]1[C@@H](O[C@H]2C[C@@H]3O[C@](O)(C2)[C@@H](C)C(=O)O[C@H](/C=C/C=C/Br)C[C@@H](C)/C=C\C[C@H](O)[C@H]3C)O[C@H](C)[C@@H](OC)[C@@H]1OC,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4569,ML00003828,,,C#CCO[C@@]1(C)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003828_numbered.png,2026-03-19 06:57:05.508827
4570,ML00008790,,,CC[C@H]1OC(=O)CCCCCCC/C=C\[C@H]2[C@H](O)[C@@H](O)C[C@H]12,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008790_numbered.png,2026-03-19 06:57:05.535789
4571,ML00008351,,,C[C@]1(O)[C@@H]2C[C@@H]3C(C(=O)O)=CO[C@H](O[C@@H]4O[C@H](COC(=O)CC(=O)O2)[C@@H](O)[C@@H](O)[C@H]4O)[C@H]31,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4572,ML00004082,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(=O)c1cccnc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4573,ML00003594,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@@H](C)[C@](C)(O)C(=O)O[C@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4574,ML00007445,,,COc1c2c(cc3c1C(c1ccco1)CC(=O)O3)C=CCCCC(=O)CCCC(C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007445_numbered.png,2026-03-19 06:57:05.591855
4575,ML00003589,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)[C@H](OC(=O)O2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003589_numbered.png,2026-03-19 06:57:05.649269
4576,ML00003868,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003868_numbered.png,2026-03-19 06:57:05.720813
4577,ML00004834,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc(-c5ccccc5)c4)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004834_numbered.png,2026-03-19 06:57:05.781101
4578,ML00008473,,,CC(=O)Oc1cc(O)c2c(c1)/C=C\CCCC(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008473_numbered.png,2026-03-19 06:57:05.805983
4579,ML00003151,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=C\C=C\c3ccc([N+](=O)[O-])cc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003151_numbered.png,2026-03-19 06:57:05.862365
4580,ML00000947,CHEMBL12204,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCOC2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000947_numbered.png,2026-03-19 06:57:05.921839
4581,ML00010712,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)/C(C)=C/[C@]1(C)OC(=O)OC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00010712_numbered.png,2026-03-19 06:57:05.979329
4582,ML00003107,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=N\OCc3cc(-c4cccc(Br)n4)no3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003107_numbered.png,2026-03-19 06:57:06.037003
4583,ML00002814,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@H]2C[C@@H](N(C)C)C[C@@H](C)O2)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002814_numbered.png,2026-03-19 06:57:06.092657
4584,ML00010190,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1ccc(C(C)C)cc1)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010190_numbered.png,2026-03-19 06:57:06.118611
4585,ML00001527,CHEMBL3650148,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(=O)N3CCOCC3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCOc3cc(C(=O)Nc4c(Cl)cncc4Cl)ccc3OC)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001527_numbered.png,2026-03-19 06:57:06.178840
4586,ML00000362,CHEMBL419849,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)NCc2cccnc2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000362_numbered.png,2026-03-19 06:57:06.204848
4587,ML00001855,CHEMBL3915384,,C[C@@H]1OC(=O)c2c(O)cc(NCC(N)=O)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001855_numbered.png,2026-03-19 06:57:06.237913
4588,ML00008724,,,COc1cc(O)c2c(c1)/C=C\C[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008724_numbered.png,2026-03-19 06:57:06.268954
4589,ML00007720,,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C/C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007720_numbered.png,2026-03-19 06:57:06.293400
4590,ML00009777,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@H]4C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4591,ML00001856,CHEMBL2012392,,C[C@H]1C/C=C/[C@H]2OC(C)(C)O[C@H]2CC/C=C/c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00001856_numbered.png,2026-03-19 06:57:06.321698
4592,ML00004404,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](OC(=O)CCc3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004404_numbered.png,2026-03-19 06:57:06.386644
4593,ML00008529,,,COc1cc(OC)c2c(c1Cl)CC(=O)CCCC[C@H]1O[C@@H]1CC(C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00008529_numbered.png,2026-03-19 06:57:06.412227
4594,ML00006437,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006437_numbered.png,2026-03-19 06:57:06.475132
4595,ML00002428,,,CC[C@H]1OC(=O)[C@H](C)C(=O)C[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)CCC(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 7, 10, 10, 11, 13, 14]",ring_size_14/standard/numbered/ML00002428_numbered.png,2026-03-19 06:57:06.524562
4596,ML00007137,,,CC[C@@H]1OC(=O)[C@@H](C)[C@@H](O)[C@H](C)[C@@H](O)[C@H](C)C[C@@H](C)C(=O)[C@@H](C)[C@@H](O)[C@@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00007137_numbered.png,2026-03-19 06:57:06.577875
4597,ML00004289,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004289_numbered.png,2026-03-19 06:57:06.633445
4598,ML00006180,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O/C=C\Cc2cncc3ccccc23)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2Cl)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006180_numbered.png,2026-03-19 06:57:06.696742
4599,ML00003137,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2ccc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003137_numbered.png,2026-03-19 06:57:06.754351
4600,ML00010577,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)[C@@H]2NN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00010577_numbered.png,2026-03-19 06:57:06.803770
4601,ML00007928,,,C[C@@H]1C[C@H]2O[C@@H]2CCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007928_numbered.png,2026-03-19 06:57:06.833313
4602,ML00005411,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@](C)(OC)[C@H]2OC(=O)CCOCCOCCCc2ccc3c(c2)c(=O)c(C(=O)O)cn3CC)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005411_numbered.png,2026-03-19 06:57:06.905331
4603,ML00000146,CHEMBL455735,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000146_numbered.png,2026-03-19 06:57:06.984369
4604,ML00008698,,,CCCCC[C@@H]1CCCCC[C@H](O)C[C@H](O)[C@@H](O)/C=C/C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 9, 11, 12]",ring_size_14/standard/numbered/ML00008698_numbered.png,2026-03-19 06:57:07.020684
4605,ML00007408,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1ccc2c(c1)OCO2)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007408_numbered.png,2026-03-19 06:57:07.048317
4606,ML00008735,,,COc1cc(O)c2c(c1Br)C(=O)OCCCCC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4607,ML00003341,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(N)=O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003341_numbered.png,2026-03-19 06:57:07.119434
4608,ML00005529,,,CCCCCCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005529_numbered.png,2026-03-19 06:57:07.184918
4609,ML00003748,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCCCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003748_numbered.png,2026-03-19 06:57:07.248906
4610,ML00007739,,,C[C@H]1C/C=C\[C@H](O)C/C=C\C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 11]",ring_size_14/standard/numbered/ML00007739_numbered.png,2026-03-19 06:57:07.277053
4611,ML00008508,,,COc1cc2c(c(OC)c1)C(=O)O[C@@H](C)C/C=C/[C@@H](O)[C@@H](O)CC/C=C/2,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00008508_numbered.png,2026-03-19 06:57:07.304696
4612,ML00006416,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NCC2CCCCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006416_numbered.png,2026-03-19 06:57:07.370678
4613,ML00002650,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccc(OC)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00002650_numbered.png,2026-03-19 06:57:07.425080
4614,ML00002828,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)Cc3ccccc3)[C@@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002828_numbered.png,2026-03-19 06:57:07.491872
4615,ML00001890,CHEMBL565044,,CC(=O)S[C@@H]1/C=C/CC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O[C@H](C)C[C@H]2O[C@@H]21,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 11]",ring_size_14/standard/numbered/ML00001890_numbered.png,2026-03-19 06:57:07.522309
4616,ML00005005,,,CCCCCCCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](OP(=O)(Oc4ccccc4)Oc4ccccc4)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@](C)(O)[C@H](OC(=O)CCCCCCC)[C@@H](C)C(=O)[C@H](C)C[C@]2(C)O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005005_numbered.png,2026-03-19 06:57:07.591376
4617,ML00005833,,,C=C[C@]12OC(=O)N(CCCCn3cnc(-c4ccc(O)nc4)c3)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005833_numbered.png,2026-03-19 06:57:07.649238
4618,ML00003043,,,COC(=O)[C@H]1[C@H](C)[C@@H]([C@H](C)[C@H](O)CC(C)=O)OC(=O)[C@H](C)[C@H](O[C@@H]2C[C@@](C)(OC)[C@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](OC)[C@@H]2O)[C@H](C)C[C@@](C)(O)C(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003043_numbered.png,2026-03-19 06:57:07.711499
4619,ML00002470,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccc3[nH]ccc3c2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002470_numbered.png,2026-03-19 06:57:07.775284
4620,ML00000784,CHEMBL583093,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN([C@H](C)c4ccnc5ncccc45)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000784_numbered.png,2026-03-19 06:57:07.832540
4621,ML00001897,CHEMBL3957257,,CNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@@H](O)C(=O)/C=C/[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001897_numbered.png,2026-03-19 06:57:07.867364
4622,ML00005749,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CC(C)(C)C[C@@H]2c2cccc3c2OCO3)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005749_numbered.png,2026-03-19 06:57:07.927711
4623,ML00010701,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)C12C=NNC2C,standard_macrolactone,14.0,,,success,,11.0,"[3, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010701_numbered.png,2026-03-19 06:57:07.983669
4624,ML00000588,CHEMBL3827641,,CCCCCCCCOc1cc(O)c2c(c1)/C=C/CCC[C@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00000588_numbered.png,2026-03-19 06:57:08.007790
4625,ML00007058,,,CC[C@H](C)[C@]1(O)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](O)(CC)[C@@H](C)OC(=O)[C@H]1O)[C@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4626,ML00002879,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccc(-c3cccs3)cc2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002879_numbered.png,2026-03-19 06:57:08.070928
4627,ML00005766,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCc2ccc(F)cc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005766_numbered.png,2026-03-19 06:57:08.136085
4628,ML00000022,CHEMBL1741,CLARITHROMYCIN,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000022_numbered.png,2026-03-19 06:57:08.201353
4629,ML00008350,,,C[C@]1(O)[C@@H]2C[C@@H]3C(C(=O)O)=CO[C@@H](O[C@@H]4O[C@H](COC(=O)CC(=O)O2)[C@@H](O)[C@H](O)[C@H]4O)[C@@H]31,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4630,ML00001589,CHEMBL1269446,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCNC(=N)N)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001589_numbered.png,2026-03-19 06:57:08.273559
4631,ML00003603,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@](C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4632,ML00003956,,,CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H]2[C@@H](OC(C)=O)[C@@]34O[C@@]2(C)COC(=O)c2cccnc2[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@H](OC(C)=O)[C@@]13COC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4633,ML00004676,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NN(C)C)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004676_numbered.png,2026-03-19 06:57:08.355703
4634,ML00009779,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(=O)[C@@H](C)[C@@H](C)c4ncccc4C(=O)OC[C@@]4(C)O[C@]1([C@H]3C)[C@@H](OC(C)=O)[C@H]4C(=O)[C@@H]2OC(C)=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4635,ML00009778,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@H]4C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4636,ML00009548,,,CC[C@H]1OC(=O)[C@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009548_numbered.png,2026-03-19 06:57:08.436367
4637,ML00005525,,,CCCCCCCCN[C@@H]1[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005525_numbered.png,2026-03-19 06:57:08.501664
4638,ML00008332,,,COc1cc(O)c2c(c1)CCC[C@H](O)CC(=O)C=CC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 9]",ring_size_14/standard/numbered/ML00008332_numbered.png,2026-03-19 06:57:08.530158
4639,ML00008795,,,CO[C@@H]1/C=C\[C@@](C)(O)/C=C\C(=O)O[C@H](C)[C@@H](C)CC[C@H]2O[C@@]12C,standard_macrolactone,14.0,,,success,,6.0,"[3, 4, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00008795_numbered.png,2026-03-19 06:57:08.567923
4640,ML00005882,,,CCC(=O)/N=C1/[C@H](C)C2OC/C(=C\C=C\c3ccccc3)CO[C@](C)(C[C@H]1C)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@H](CC)[C@@]2(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005882_numbered.png,2026-03-19 06:57:08.624884
4641,ML00003108,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(OC)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003108_numbered.png,2026-03-19 06:57:08.682598
4642,ML00007701,,,C[C@@H]1C/C=C/CC/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007701_numbered.png,2026-03-19 06:57:08.707493
4643,ML00003162,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C/C=C/Cn3cnc(-c4cccnc4)c3)C(=O)N[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00003162_numbered.png,2026-03-19 06:57:08.766152
4644,ML00002192,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CNC(=O)OCc3cnc4ccccc4n3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002192_numbered.png,2026-03-19 06:57:08.822403
4645,ML00007896,,,C[C@H]1C[C@@H](O)CC(=O)CCCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 5, 7]",ring_size_14/standard/numbered/ML00007896_numbered.png,2026-03-19 06:57:08.850751
4646,ML00006081,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2ccc3nccnc3c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006081_numbered.png,2026-03-19 06:57:08.919040
4647,ML00001716,CHEMBL3970061,,C[C@@H]1OC(=O)c2c(O)cc(NCC(O)CO)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001716_numbered.png,2026-03-19 06:57:08.960232
4648,ML00002221,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1cccnc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4649,ML00004350,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccccc3Cl)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004350_numbered.png,2026-03-19 06:57:09.031208
4650,ML00003478,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3ccccn3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003478_numbered.png,2026-03-19 06:57:09.097965
4651,ML00010737,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(C)=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)C2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010737_numbered.png,2026-03-19 06:57:09.167662
4652,ML00009789,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)/C(=N\O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009789_numbered.png,2026-03-19 06:57:09.240879
4653,ML00006080,,,CC[C@H]1OC(=O)[C@H](C)[C@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)/C(=N\O)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006080_numbered.png,2026-03-19 06:57:09.310064
4654,ML00006084,,,CC(=O)O[C@@H]1[C@H]2[C@@H](OC(=O)C(C)C)[C@@H](OC(=O)C(C)C)[C@]3(COC(=O)C(C)C)[C@@H](OC(C)=O)[C@@H](OC(=O)c4ccc(=O)n(C)c4)[C@@H]4OC(=O)[C@@H](C)[C@H](C)c5ccncc5C(=O)OC[C@]2(C)O[C@]13[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4655,ML00006996,,,COc1cc(O)c2c(c1Br)C(=O)OCC(=O)NCC(=O)N[C@H](c1nc(CNC(C)C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4656,ML00001788,CHEMBL1097280,,Cc1nc2c3c(c(O)cc2n1C)C(=O)O[C@@H](C)[C@H](C)/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/3,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001788_numbered.png,2026-03-19 06:57:09.369014
4657,ML00010211,,,C#CCO[C@@H]1[C@@H](C)[C@H](O)[C@@H](C)C(=O)O[C@H](CC)C(C)(C)[C@@H]2OC(C)(C)O[C@H]([C@@H]2C)[C@H](C)C[C@@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010211_numbered.png,2026-03-19 06:57:09.434215
4658,ML00004308,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3c[nH]c4ccccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004308_numbered.png,2026-03-19 06:57:09.498534
4659,ML00005783,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O/C=C\Cc2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005783_numbered.png,2026-03-19 06:57:09.575734
4660,ML00002347,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cc(-c4ccccn4)nn3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002347_numbered.png,2026-03-19 06:57:09.644827
4661,ML00008009,,,CC1CCC(O)/C=C/C(=O)OC(C)C(O)/C=C/C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4662,ML00008434,,,CC[C@H]1OC(=O)[C@H](C)C(=O)/C(C)=C\[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)O,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 4, 7, 8, 10, 12, 13, 14]",ring_size_14/standard/numbered/ML00008434_numbered.png,2026-03-19 06:57:09.707933
4663,ML00008536,,,C[C@H]1CCC[C@@H](O)CCCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008536_numbered.png,2026-03-19 06:57:09.735993
4664,ML00007766,,,C[C@@H]1C[C@@H]2O[C@@H]2C[C@H](O)/C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 8, 11]",ring_size_14/standard/numbered/ML00007766_numbered.png,2026-03-19 06:57:09.769088
4665,ML00004130,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2cccnc2)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004130_numbered.png,2026-03-19 06:57:09.833027
4666,ML00009446,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009446_numbered.png,2026-03-19 06:57:09.908471
4667,ML00003289,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003289_numbered.png,2026-03-19 06:57:09.976858
4668,ML00006065,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](COCc3ccccc3)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cc(-c4ccccn4)nn3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006065_numbered.png,2026-03-19 06:57:10.047499
4669,ML00007404,,,CCCCCCCC[C@H]1CC(=O)N[C@@H](CO)C(=O)O[C@H](CCCCCCC)CC(=O)N[C@@H](CO)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4670,ML00003468,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccncc3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003468_numbered.png,2026-03-19 06:57:10.132757
4671,ML00003655,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4672,ML00010231,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C/[C@H]1C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010231_numbered.png,2026-03-19 06:57:10.198238
4673,ML00003433,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#N)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003433_numbered.png,2026-03-19 06:57:10.276945
4674,ML00005874,,,C=C[C@]12OC(=O)N(CCCCn3cnc(-c4cnc(C)cn4)c3)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005874_numbered.png,2026-03-19 06:57:10.343147
4675,ML00001007,CHEMBL84809,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)N(CCO)CCO)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00001007_numbered.png,2026-03-19 06:57:10.373319
4676,ML00009741,,,CO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009741_numbered.png,2026-03-19 06:57:10.438717
4677,ML00002409,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2OC(=O)N3C)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2N(c3ccc(N4CCOCC4)c(F)c3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002409_numbered.png,2026-03-19 06:57:10.500694
4678,ML00004753,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004753_numbered.png,2026-03-19 06:57:10.564899
4679,ML00002784,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002784_numbered.png,2026-03-19 06:57:10.626288
4680,ML00004094,,,CC(=O)O[C@H]1[C@@H]2[C@@H](OC(C)=O)[C@@]34O[C@@]2(C)COC(=O)c2cccnc2[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]3(COC(=O)C(C)C)[C@H]1OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4681,ML00003163,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc4cnn(C(N)=O)c4c3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00003163_numbered.png,2026-03-19 06:57:10.694483
4682,ML00002182,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCc1cnc(-c2cccnc2)s1,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002182_numbered.png,2026-03-19 06:57:10.748108
4683,ML00002363,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)/C=C/c2ccc(Cl)cc2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002363_numbered.png,2026-03-19 06:57:10.811424
4684,ML00003803,,,CCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003803_numbered.png,2026-03-19 06:57:10.876619
4685,ML00003736,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3ccc(N)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003736_numbered.png,2026-03-19 06:57:10.930953
4686,ML00002218,,,CC(=O)OCC12C(OC(C)=O)C(OC(=O)c3cccnc3)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)OC(C(OC(C)=O)C2OC(C)=O)C4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4687,ML00002525,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2ccccc2)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002525_numbered.png,2026-03-19 06:57:10.993904
4688,ML00008809,,,CO[C@H]1/C=C\[C@@](C)(O)/C=C\C(=O)O[C@H](C)[C@@H](C)CC/C=C\1CO,standard_macrolactone,14.0,,,success,,6.0,"[3, 4, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00008809_numbered.png,2026-03-19 06:57:11.032620
4689,ML00005848,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccc(F)c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccccc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005848_numbered.png,2026-03-19 06:57:11.099328
4690,ML00003475,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(N)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003475_numbered.png,2026-03-19 06:57:11.157918
4691,ML00006503,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4692,ML00003814,,,CCC(=O)O[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003814_numbered.png,2026-03-19 06:57:11.241685
4693,ML00009796,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009796_numbered.png,2026-03-19 06:57:11.307156
4694,ML00000791,CHEMBL2159131,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2O/C(=N\CCCN(C)C)N3C)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000791_numbered.png,2026-03-19 06:57:11.374036
4695,ML00002862,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3cnccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002862_numbered.png,2026-03-19 06:57:11.435428
4696,ML00009691,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4697,ML00006635,,,O=C1OCC/C=C/CC/C=C/C(=N/OCC(=O)N2CCCCC2)Cc2cc(O)cc(O)c21,standard_macrolactone,14.0,,,success,,1.0,[11],ring_size_14/standard/numbered/ML00006635_numbered.png,2026-03-19 06:57:11.466842
4698,ML00003628,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@]3(C)[C@H](OC(C)=O)[C@@]14O[C@H]3COC(=O)c1cccnc1[C@@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4699,ML00006163,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC(=O)CNC(=O)CCCOc3ccc([N+](=O)[O-])cc3OC)[C@H]2O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006163_numbered.png,2026-03-19 06:57:11.546411
4700,ML00003051,,,CC/C=N\C(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003051_numbered.png,2026-03-19 06:57:11.625969
4701,ML00000803,CHEMBL583299,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4c(O)cnc5cccnc45)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000803_numbered.png,2026-03-19 06:57:11.693116
4702,ML00002604,,,CC[C@@H]1OC(=O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@H](C)/C(=N\OCOCCOC)[C@@H](C)[C@H](O)[C@@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002604_numbered.png,2026-03-19 06:57:11.768207
4703,ML00009589,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nnc(C)s3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009589_numbered.png,2026-03-19 06:57:11.835292
4704,ML00009468,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC2CCCN(C)C2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009468_numbered.png,2026-03-19 06:57:11.910284
4705,ML00010651,,,COc1ccc2cc(C3CC(=O)Oc4cc5c(c(OC)c43)C(=O)OC(C)CCCC(=O)CCCC=C5)c(=O)n(C)c2c1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010651_numbered.png,2026-03-19 06:57:11.941413
4706,ML00002527,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2ccc3ncncc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002527_numbered.png,2026-03-19 06:57:12.009265
4707,ML00001811,CHEMBL3629241,,COC1=CC(O)C2=C(/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O)C1(F)F,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001811_numbered.png,2026-03-19 06:57:12.046688
4708,ML00001555,CHEMBL1395149,,CC[C@@H]1OC(=O)[C@H](C)[C@H](O[C@@H]2C[C@](C)(OC)[C@H](O)[C@H](C)O2)[C@H](C)[C@H](O[C@@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@H](C)[C@@H]2N[C@H](COCCOC)O[C@H]([C@@H]2C)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001555_numbered.png,2026-03-19 06:57:12.131403
4709,ML00000206,CHEMBL1214759,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000206_numbered.png,2026-03-19 06:57:12.206077
4710,ML00003403,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](c3ccsc3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003403_numbered.png,2026-03-19 06:57:12.279003
4711,ML00003142,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@H]2C[C@H](O)[C@@H](N(C)C)[C@@H](C)O2)[C@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)/C(=N\OC(C)=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003142_numbered.png,2026-03-19 06:57:12.348936
4712,ML00002926,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCc2cccs2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002926_numbered.png,2026-03-19 06:57:12.421552
4713,ML00004117,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3sccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004117_numbered.png,2026-03-19 06:57:12.490031
4714,ML00003752,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccc([N+](=O)[O-])c2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003752_numbered.png,2026-03-19 06:57:12.564765
4715,ML00000011,CHEMBL532,ERYTHROMYCIN,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000011_numbered.png,2026-03-19 06:57:12.631359
4716,ML00005642,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)/C=C/c2cccc3ccccc23)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005642_numbered.png,2026-03-19 06:57:12.695260
4717,ML00007903,,,C[C@H]1CCC[C@H](O)CCC/C=C/c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007903_numbered.png,2026-03-19 06:57:12.720030
4718,ML00008476,,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C(C)=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 6, 7, 8, 9]",ring_size_14/standard/numbered/ML00008476_numbered.png,2026-03-19 06:57:12.753685
4719,ML00003621,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)/C(=N\O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003621_numbered.png,2026-03-19 06:57:12.817370
4720,ML00003079,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NCCCCCO)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003079_numbered.png,2026-03-19 06:57:12.881036
4721,ML00002711,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CC(C)(C)C[C@@H]2c2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002711_numbered.png,2026-03-19 06:57:12.947324
4722,ML00005932,,,C=C[C@]12OC(=O)N(CCCCn3cnc(-c4ccc(NC)nc4)c3)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005932_numbered.png,2026-03-19 06:57:13.008818
4723,ML00007963,,,C[C@H]1C[C@H](O)CC(=O)CCC/C=C\c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 5, 7]",ring_size_14/standard/numbered/ML00007963_numbered.png,2026-03-19 06:57:13.038698
4724,ML00008999,,,CO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00008999_numbered.png,2026-03-19 06:57:13.101520
4725,ML00007972,,,C[C@@H]1C[C@H]2O[C@@H]2CCCCC(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007972_numbered.png,2026-03-19 06:57:13.128656
4726,ML00007626,,,COc1cc(OCC(=O)Nc2ccccc2Cl)cc2c1C(=O)OC(C)CCCC(=O)CCCCC2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007626_numbered.png,2026-03-19 06:57:13.154207
4727,ML00003812,,,CCC(=O)O[C@H]1C(O[C@@H]2C(C)[C@H](O[C@H]3C[C@@](C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)[C@@](C)(O)C(O)[C@H](C)C(=O)C(C)C[C@]2(C)O)OC(C)CC1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003812_numbered.png,2026-03-19 06:57:13.219853
4728,ML00002392,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccc(NC(C)=O)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00002392_numbered.png,2026-03-19 06:57:13.278232
4729,ML00000223,CHEMBL1214763,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000223_numbered.png,2026-03-19 06:57:13.334176
4730,ML00003110,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cnc3ccccc3c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003110_numbered.png,2026-03-19 06:57:13.394970
4731,ML00006650,,,C/C1=C/CC[C@H](C)[C@@H](C)OC(=O)/C=C\[C@](C)(O)CC[C@@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O,standard_macrolactone,14.0,,,success,,6.0,"[3, 4, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00006650_numbered.png,2026-03-19 06:57:13.435145
4732,ML00006182,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cnc3ccccc3c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006182_numbered.png,2026-03-19 06:57:13.495690
4733,ML00003056,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](n2ccc(C=O)c2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003056_numbered.png,2026-03-19 06:57:13.561794
4734,ML00003717,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NC2CCCCC2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003717_numbered.png,2026-03-19 06:57:13.627748
4735,ML00003865,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=N/NC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003865_numbered.png,2026-03-19 06:57:13.693194
4736,ML00008532,,,COc1cc(O)c(Cl)c2c1C(=O)O[C@@H](C)CC[C@@H](O)CC/C=C/C(=O)C2,standard_macrolactone,14.0,,,success,,3.0,"[3, 6, 11]",ring_size_14/standard/numbered/ML00008532_numbered.png,2026-03-19 06:57:13.721439
4737,ML00006452,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(=O)c1ccccc1)[C@H]4C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4738,ML00003311,,,C=CCO[C@@H]1C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003311_numbered.png,2026-03-19 06:57:13.785178
4739,ML00001859,CHEMBL3898540,,CCNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@@H](O)C(=O)/C=C/[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001859_numbered.png,2026-03-19 06:57:13.821401
4740,ML00008721,,,COc1cc(O)c2c(c1Cl)C(=O)OCCCCC(=S)N[C@H](c1nc(CN)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4741,ML00007981,,,C[C@H]1CCC/C=C\[C@H](O)[C@@H](O)[C@H](O)[C@H](O)/C=C\C(=O)O1,standard_macrolactone,14.0,,,success,,5.0,"[3, 9, 10, 11, 12]",ring_size_14/standard/numbered/ML00007981_numbered.png,2026-03-19 06:57:13.863673
4742,ML00000045,CHEMBL1651521,,COc1cc(O)c2c(c1)CCC[C@H](O)CC(=O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 9]",ring_size_14/standard/numbered/ML00000045_numbered.png,2026-03-19 06:57:13.891455
4743,ML00002731,,,CCCCC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002731_numbered.png,2026-03-19 06:57:13.954760
4744,ML00000145,CHEMBL3736342,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000145_numbered.png,2026-03-19 06:57:14.007288
4745,ML00010147,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1ccc2ncccc2c1)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010147_numbered.png,2026-03-19 06:57:14.032619
4746,ML00002242,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC=Cc2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002242_numbered.png,2026-03-19 06:57:14.088862
4747,ML00008369,,,COc1cc(O)c2c(c1)CCCCCC(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008369_numbered.png,2026-03-19 06:57:14.113401
4748,ML00003215,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](O)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3cnccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@@H]2NC(=S)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003215_numbered.png,2026-03-19 06:57:14.169724
4749,ML00006230,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3cccnc3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc5ncccc54)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006230_numbered.png,2026-03-19 06:57:14.228193
4750,ML00006413,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OCCNCCCCCCNCc2ccc(OC)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006413_numbered.png,2026-03-19 06:57:14.290551
4751,ML00002262,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](O)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C(F)=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@@H]2NC(=S)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002262_numbered.png,2026-03-19 06:57:14.348138
4752,ML00005915,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCC#Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2OCC[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2Cl)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005915_numbered.png,2026-03-19 06:57:14.420339
4753,ML00010644,,,C=C(C)COc1ccc(C2CC(=O)Oc3cc4c(c(OC)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1OC,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010644_numbered.png,2026-03-19 06:57:14.446769
4754,ML00001397,CHEMBL122437,,O=C1CCC[C@H](CN2CCOCC2)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC2CN3CCC2CC3)CO1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4755,ML00002965,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(-c4ncccn4)s3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002965_numbered.png,2026-03-19 06:57:14.509267
4756,ML00004554,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004554_numbered.png,2026-03-19 06:57:14.575790
4757,ML00008694,,,CCCCC[C@H]1CCCCC[C@H](O)C[C@H](O)[C@@H](O)/C=C/C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 9, 11, 12]",ring_size_14/standard/numbered/ML00008694_numbered.png,2026-03-19 06:57:14.606735
4758,ML00001008,CHEMBL1079085,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](c1ccccc1)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001008_numbered.png,2026-03-19 06:57:14.640863
4759,ML00005881,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=C\C=C\c3ccc(OC)cc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005881_numbered.png,2026-03-19 06:57:14.699076
4760,ML00002499,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4761,ML00010244,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1ccc(OCC(N)=O)cc1)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010244_numbered.png,2026-03-19 06:57:14.732696
4762,ML00004343,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccc(F)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004343_numbered.png,2026-03-19 06:57:14.785732
4763,ML00002373,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nc4cc(OC)ccc4s3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002373_numbered.png,2026-03-19 06:57:14.842820
4764,ML00010652,,,COc1c2c(cc3c1C(c1ccc(OC)c4ccccc14)CC(=O)O3)C=CCCCC(=O)CCCC(C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010652_numbered.png,2026-03-19 06:57:14.871557
4765,ML00006037,,,CCCNC(=O)CCCCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006037_numbered.png,2026-03-19 06:57:14.946634
4766,ML00006175,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2cncc3ccccc23)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006175_numbered.png,2026-03-19 06:57:15.018200
4767,ML00006989,,,COc1cc(O)c2c(c1C)C(=O)OC[C@@H](CO)CCC(=S)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4768,ML00000858,CHEMBL1317549,,CC[C@@H]1OC(=O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)C(C)[C@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@](C)(O)C[C@H](C)C(=O)[C@@H](C)[C@H](O)[C@@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000858_numbered.png,2026-03-19 06:57:15.101477
4769,ML00010828,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@]2(C)O[C@H]2[C@]1(C)O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010828_numbered.png,2026-03-19 06:57:15.167174
4770,ML00006759,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3ccccc3)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00006759_numbered.png,2026-03-19 06:57:15.192735
4771,ML00003350,,,CC(=O)OC[C@]12[C@H](O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4772,ML00010819,,,COc1c2c(cc3c1C(c1ccc(C(C)C)cc1)CC(=O)O3)C=CCCCC(=O)CCCC(C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010819_numbered.png,2026-03-19 06:57:15.226235
4773,ML00001209,CHEMBL1256539,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001209_numbered.png,2026-03-19 06:57:15.290482
4774,ML00003799,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003799_numbered.png,2026-03-19 06:57:15.354498
4775,ML00003411,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCCNCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003411_numbered.png,2026-03-19 06:57:15.424335
4776,ML00002780,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(=O)CO)[C@H](C)C(OC/C(=C\C=C\c3ccccc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002780_numbered.png,2026-03-19 06:57:15.490756
4777,ML00002453,,,C=CCOC1[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cncnc2)[C@H](C)[C@@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002453_numbered.png,2026-03-19 06:57:15.551892
4778,ML00001082,CHEMBL1094508,PAECILOMYCIN E,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)[C@@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001082_numbered.png,2026-03-19 06:57:15.584299
4779,ML00001628,CHEMBL203272,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](OC(=O)CC(=O)OCc3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001628_numbered.png,2026-03-19 06:57:15.650588
4780,ML00008701,,,CCCCC[C@H]1CCCCC[C@@H](O)C[C@@H](O)[C@@H](O)/C=C/C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 9, 11, 12]",ring_size_14/standard/numbered/ML00008701_numbered.png,2026-03-19 06:57:15.681853
4781,ML00009719,,,COC(=O)c1ccc(COc2cc3c(c(OCc4ccc(C(=O)OC)cc4)c2)C(=O)OC(C)CCCC(=O)CCCC=C3)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00009719_numbered.png,2026-03-19 06:57:15.707312
4782,ML00003584,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cccnc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003584_numbered.png,2026-03-19 06:57:15.764214
4783,ML00009842,,,CCOCCCN1C(=O)O[C@]2(C)[C@@H](CC)OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]12,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00009842_numbered.png,2026-03-19 06:57:15.816121
4784,ML00010248,,,CC[C@H]1OC(=O)[C@@H](C)[C@H](O[C@@H]2C[C@](C)(O)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@H](O)[C@@](C)(O)C[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010248_numbered.png,2026-03-19 06:57:15.875610
4785,ML00008729,,,COc1cc(O)c2c(c1C)C(=O)OCC(=O)NCC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4786,ML00003609,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@H]4C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4787,ML00008539,,,C[C@H]1CCC[C@@H](O)[C@@H](O)CCC(O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 11]",ring_size_14/standard/numbered/ML00008539_numbered.png,2026-03-19 06:57:15.921252
4788,ML00007670,,,C=C1/C=C\C(=O)NC(C)C(=O)NC(C(C)C)C(=O)OC(C(CCO)C(C)CCCCCC)C(=O)N1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4789,ML00004174,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004174_numbered.png,2026-03-19 06:57:15.992946
4790,ML00000037,CHEMBL1173442,AIGIALOMYCIN D,C[C@H]1C/C=C/[C@@H](O)[C@@H](O)CC/C=C/c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 8]",ring_size_14/standard/numbered/ML00000037_numbered.png,2026-03-19 06:57:16.021502
4791,ML00010899,,,CC[C@@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010899_numbered.png,2026-03-19 06:57:16.077302
4792,ML00002343,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)/C=C/c2ccc([N+](=O)[O-])cc2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002343_numbered.png,2026-03-19 06:57:16.140966
4793,ML00002606,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002606_numbered.png,2026-03-19 06:57:16.206719
4794,ML00009528,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/N=C2\O[C@]1(C)C=C2C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4795,ML00009599,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nccs3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009599_numbered.png,2026-03-19 06:57:16.270354
4796,ML00004872,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3cccnc3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc(-c5ccc(N)nc5)c4)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004872_numbered.png,2026-03-19 06:57:16.329421
4797,ML00003291,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4cccnc4)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003291_numbered.png,2026-03-19 06:57:16.385262
4798,ML00007933,,,C[C@@H]1C[C@H]2O[C@H]2CC/C=C/[C@@H](O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007933_numbered.png,2026-03-19 06:57:16.410265
4799,ML00003004,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4800,ML00001311,CHEMBL1256538,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3(C)CC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001311_numbered.png,2026-03-19 06:57:16.481765
4801,ML00007001,,,C=C1/C=C(\C)[C@H](CC)OC(=O)[C@H](C)C(=O)[C@@](O)(CO)[C@H](OC)/C=C/[C@@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 11, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00007001_numbered.png,2026-03-19 06:57:16.531892
4802,ML00006125,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)C(C)C)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006125_numbered.png,2026-03-19 06:57:16.590988
4803,ML00008448,,,COc1cc2c(c(OC)c1)C(=O)O[C@@H](C)CCC[C@H](O)CCCCC2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008448_numbered.png,2026-03-19 06:57:16.615975
4804,ML00010792,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@](C)(O)[C@H]2OS(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010792_numbered.png,2026-03-19 06:57:16.673890
4805,ML00007805,,,CC1CC2OC2/C=C/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007805_numbered.png,2026-03-19 06:57:16.698759
4806,ML00007061,,,CC[C@H](C)[C@@]1(O)CC(=O)O[C@H](C)[C@@](O)(CC)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4807,ML00005899,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2C(NC(=O)CCc3cnc4c(OC)cccc4c3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005899_numbered.png,2026-03-19 06:57:16.772004
4808,ML00003560,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3cc([N+](=O)[O-])ccc3O)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003560_numbered.png,2026-03-19 06:57:16.835617
4809,ML00002161,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2ccc3nccnc3c2)C[C@@H](C)/C(=N\OC)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002161_numbered.png,2026-03-19 06:57:16.893496
4810,ML00003285,,,C#CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3cccnc3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003285_numbered.png,2026-03-19 06:57:16.957535
4811,ML00010826,,,COc1cc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc(OC)c1OC(C)=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010826_numbered.png,2026-03-19 06:57:16.983602
4812,ML00002533,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2cn(-c3cnccn3)cn2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002533_numbered.png,2026-03-19 06:57:17.046091
4813,ML00009734,,,COc1ccc(CCOc2ccc(C3CC(=O)Oc4cc5c(c(O)c43)C(=O)OC(C)CCCC(=O)CCCC=C5)cc2)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00009734_numbered.png,2026-03-19 06:57:17.073484
4814,ML00004116,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2ccc(-c3nnn(C)n3)s2)C[C@@H](C)/C(=N\OC)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00004116_numbered.png,2026-03-19 06:57:17.140349
4815,ML00003839,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003839_numbered.png,2026-03-19 06:57:17.215514
4816,ML00004579,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNCc2ccncc2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004579_numbered.png,2026-03-19 06:57:17.295220
4817,ML00010188,,,CC(C)Oc1cccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)c1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010188_numbered.png,2026-03-19 06:57:17.326256
4818,ML00005266,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNCc2cccc(OC)c2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005266_numbered.png,2026-03-19 06:57:17.400649
4819,ML00010603,,,COc1ccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)c2ccccc12,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010603_numbered.png,2026-03-19 06:57:17.430813
4820,ML00004294,,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NCCCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004294_numbered.png,2026-03-19 06:57:17.497338
4821,ML00010227,,,CCC1OC(=O)C(C)C(=O)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)CC(C)C(=O)C=CC1(C)O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010227_numbered.png,2026-03-19 06:57:17.559083
4822,ML00005678,,,CCCCN(C)[C@@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4cnc(-c5cccnc5)c4)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)O[C@H](C)C1,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005678_numbered.png,2026-03-19 06:57:17.626304
4823,ML00001047,CHEMBL1078955,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C(F)(F)F)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00001047_numbered.png,2026-03-19 06:57:17.663910
4824,ML00005914,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccc(C(=O)c3ccccc3)s2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005914_numbered.png,2026-03-19 06:57:17.726207
4825,ML00003288,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003288_numbered.png,2026-03-19 06:57:17.782600
4826,ML00010584,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00010584_numbered.png,2026-03-19 06:57:17.841965
4827,ML00003143,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCc1ncc(-c2ccccc2)s1,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003143_numbered.png,2026-03-19 06:57:17.907027
4828,ML00006471,,,CCCCC/C=C/CCCN[C@@H]1[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006471_numbered.png,2026-03-19 06:57:17.980681
4829,ML00006399,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006399_numbered.png,2026-03-19 06:57:18.048175
4830,ML00007648,,,C/C1=C/[C@@H](C)[C@H](O)C/C=C/CC/C=C/C(=O)O[C@@H]1[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1,standard_macrolactone,14.0,,,success,,4.0,"[3, 4, 6, 7]",ring_size_14/standard/numbered/ML00007648_numbered.png,2026-03-19 06:57:18.082535
4831,ML00000643,CHEMBL252324,,C[C@@H]1C[C@H]2O[C@@H]2C[C@H](O)/C=C/C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 8, 11]",ring_size_14/standard/numbered/ML00000643_numbered.png,2026-03-19 06:57:18.110873
4832,ML00010096,,,Cc1c(C)c(C)c(COc2cc(O)c3c(c2)C=CCCCC(=O)CCCC(C)OC3=O)c(C)c1C,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010096_numbered.png,2026-03-19 06:57:18.135571
4833,ML00008719,,,COc1cc(O)c2c(c1Br)C(=O)OCCN(S(C)(=O)=O)CC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4834,ML00001446,CHEMBL410940,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(CC3CC3)CC3CC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(F)c(Cl)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001446_numbered.png,2026-03-19 06:57:18.201280
4835,ML00000692,CHEMBL406517,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000692_numbered.png,2026-03-19 06:57:18.264575
4836,ML00004695,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCC(=O)NCc3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004695_numbered.png,2026-03-19 06:57:18.329785
4837,ML00004688,,,CCCCCCCCCCCCC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004688_numbered.png,2026-03-19 06:57:18.393523
4838,ML00005832,,,C=C[C@]12OC(=O)N(CCN(C)Cc3cnc(-c4cccnc4)s3)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005832_numbered.png,2026-03-19 06:57:18.453602
4839,ML00002417,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CC/C=C/c3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002417_numbered.png,2026-03-19 06:57:18.517038
4840,ML00002501,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(=O)c1ccc(=O)n(C)c1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4841,ML00005904,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCc3ccc(Oc4ccccc4)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00005904_numbered.png,2026-03-19 06:57:18.587414
4842,ML00007120,,,COc1cc(OCC2CO2)cc2c1C(=O)OC(C)CCCC(=O)CCCC=C2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007120_numbered.png,2026-03-19 06:57:18.617498
4843,ML00007639,,,CC[C@H](/C=C(\C)[C@@H]1C[C@@H](OC)C[C@@H]2O[C@@](O)(CC(=O)C2(C)C)C[C@@H](O)C[C@@H](OC)[C@H](O)C(=O)O1)CO,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4844,ML00001875,CHEMBL1098878,,COc1cc(O)c2c(c1)NC(=O)C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4845,ML00003819,,,COC(=O)[C@H]1[C@@H](C)C(=O)[C@](C)(O)C[C@@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](OC)[C@@H]2O)[C@H](C)[C@@H](O[C@H]2C[C@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)C(=O)O[C@@H]([C@H](C)[C@H](C)O)[C@@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003819_numbered.png,2026-03-19 06:57:18.706225
4846,ML00007755,,,C[C@H]1C/C=C\[C@H](O)C/C=C\C(=O)Cc2cccc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 11]",ring_size_14/standard/numbered/ML00007755_numbered.png,2026-03-19 06:57:18.740283
4847,ML00005877,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@H]2N(NCCCc3ccnc4c(OC)cccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005877_numbered.png,2026-03-19 06:57:18.805010
4848,ML00006964,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006964_numbered.png,2026-03-19 06:57:18.853304
4849,ML00010198,,,COc1cc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)ccc1OCC(N)=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010198_numbered.png,2026-03-19 06:57:18.879015
4850,ML00002141,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CNC(=O)OCc3cccc4nccnc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002141_numbered.png,2026-03-19 06:57:18.943265
4851,ML00007892,,,C[C@H]1C[C@H](O)[C@@H](O)CCCCC(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 6, 11]",ring_size_14/standard/numbered/ML00007892_numbered.png,2026-03-19 06:57:18.980042
4852,ML00004324,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCn1cnc2ncccc21,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004324_numbered.png,2026-03-19 06:57:19.043424
4853,ML00006933,,,COc1cc(O)c2c(c1C)C(=O)O[C@H](CO)CCCC(=S)N[C@H](c1nc(CN)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4854,ML00003146,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCCCc2cnc3ccccc3c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003146_numbered.png,2026-03-19 06:57:19.117209
4855,ML00010598,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3ccccc3)cc(OCc3ccccc3)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010598_numbered.png,2026-03-19 06:57:19.147327
4856,ML00002497,,,CC(=O)OC[C@]12[C@H](O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4857,ML00008045,,,CC1CCCCCCCCCCCOC1=O,standard_macrolactone,14.0,,,success,,1.0,[14],ring_size_14/standard/numbered/ML00008045_numbered.png,2026-03-19 06:57:19.179273
4858,ML00009712,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4859,ML00006088,,,CNC1CC#CC(C(=O)O)C(=O)OCC2OC(OCC1N)C(OOc1cc3c(cc1Cc1cc(O)cc(CC4CCCC4)c1)OCC1c4cc5c(c(CC(C)C)c4OC31)OCO5)C(O)C2O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4860,ML00001494,CHEMBL442482,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C3CCCC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001494_numbered.png,2026-03-19 06:57:19.267406
4861,ML00005781,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC/C(=N\OCCCCc3ccccc3)CCO[C@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]3NC(=O)O[C@]13C)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00005781_numbered.png,2026-03-19 06:57:19.325676
4862,ML00004674,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCCC(=O)NC3CCCCC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004674_numbered.png,2026-03-19 06:57:19.396175
4863,ML00007630,,,CC[C@H](/C=C(/C)[C@@H]1C[C@@H](OC)C[C@@H]2O[C@@](O)(CC(=O)C2(C)C)C[C@@H](O)C[C@@H](OC)[C@H](O)C(=O)O1)CO,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4864,ML00006625,,,CC(=O)Oc1cc(OC(C)=O)c2c(c1Cl)CC(OC(C)=O)/C=C/CC[C@H]1O[C@@H]1C[C@@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00006625_numbered.png,2026-03-19 06:57:19.429848
4865,ML00008535,,,CC[C@@H]1OC(=O)CCCC/C=C\C/C=C\[C@H]2[C@H]1C[C@@H](Cl)[C@@H]2O,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008535_numbered.png,2026-03-19 06:57:19.452618
4866,ML00006137,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006137_numbered.png,2026-03-19 06:57:19.517513
4867,ML00002534,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2cn(-c3ncccn3)cn2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002534_numbered.png,2026-03-19 06:57:19.580394
4868,ML00008006,,,C[C@@H]1C/C=C\C(=O)O[C@H](C)C[C@@H](O)[C@@H](O)/C=C\C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4869,ML00008808,,,CO[C@H]1/C=C\[C@@](C)(O)/C=C\C(=O)O[C@H](C)[C@@](C)(O)CC/C=C\1C,standard_macrolactone,14.0,,,success,,7.0,"[3, 4, 4, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00008808_numbered.png,2026-03-19 06:57:19.629019
4870,ML00010148,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1cc2ccccc2nc1O)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010148_numbered.png,2026-03-19 06:57:19.656124
4871,ML00006584,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006584_numbered.png,2026-03-19 06:57:19.710349
4872,ML00002183,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCCNCc2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002183_numbered.png,2026-03-19 06:57:19.769327
4873,ML00006235,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](COCc3ccccc3)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cc(-c4cccc(N)c4)nn3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00006235_numbered.png,2026-03-19 06:57:19.832610
4874,ML00005962,,,CCCCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005962_numbered.png,2026-03-19 06:57:19.898227
4875,ML00000951,CHEMBL3735456,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCC(=O)NO)nn4)cc3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000951_numbered.png,2026-03-19 06:57:19.953434
4876,ML00005303,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCCCOCCCc3ccc4c(c3)CC(C(=O)O)=CN4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005303_numbered.png,2026-03-19 06:57:20.022808
4877,ML00006674,,,C[C@@H]1C[C@@H]2O[C@@H]2/C=C\C=C/C(=O)Cc2c(Cl)c(O[C@H]3O[C@H](CO)[C@@H](O)[C@@H]3O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00006674_numbered.png,2026-03-19 06:57:20.049172
4878,ML00004413,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004413_numbered.png,2026-03-19 06:57:20.115378
4879,ML00008361,,,COc1cc(O)c2c(c1)/C=C/CC(O)C(O)C(=O)CCCC(C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008361_numbered.png,2026-03-19 06:57:20.146964
4880,ML00010689,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1cc2cccc4c2n(c1=O)CCC4)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010689_numbered.png,2026-03-19 06:57:20.172285
4881,ML00002607,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)C[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@@H]2N[C@@H](COCCOC)O[C@H]([C@H]2C)[C@]1(C)O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 4, 6, 8, 10, 10, 11, 13, 14]",ring_size_14/standard/numbered/ML00002607_numbered.png,2026-03-19 06:57:20.226744
4882,ML00006116,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N(CC)CC)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-n3cccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006116_numbered.png,2026-03-19 06:57:20.286097
4883,ML00008525,,,COc1cc(O)c2c(c1C)C(=O)OCCCCC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4884,ML00001091,CHEMBL1078698,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001091_numbered.png,2026-03-19 06:57:20.327664
4885,ML00003810,,,CCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003810_numbered.png,2026-03-19 06:57:20.396716
4886,ML00002461,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002461_numbered.png,2026-03-19 06:57:20.464126
4887,ML00007591,,,CCCCCCC[C@@H]1CC(=O)N[C@@H](CO)C(=O)O[C@H](CCCCCCC)CC(=O)N[C@@H](CO)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4888,ML00006502,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)C3C(OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)OC([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4889,ML00001218,CHEMBL382132,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](OC(=O)CC(=O)O)[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001218_numbered.png,2026-03-19 06:57:20.558576
4890,ML00007929,,,C[C@@H]1C[C@@H]2O[C@@H]2CCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007929_numbered.png,2026-03-19 06:57:20.589533
4891,ML00001606,CHEMBL582871,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCCO)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001606_numbered.png,2026-03-19 06:57:20.665691
4892,ML00002894,,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)N/C=C/c2ccc(-c3ccncc3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002894_numbered.png,2026-03-19 06:57:20.732912
4893,ML00001863,CHEMBL3828600,,CCC(=O)Oc1cc(O)c2c(c1)/C=C/CCC[C@@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00001863_numbered.png,2026-03-19 06:57:20.762562
4894,ML00000824,CHEMBL333369,,CCCCC1CCCC(=O)OC[C@H](NC(=O)C(Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC2CCCCC2)[C@@H](O)C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4895,ML00001225,CHEMBL1778155,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001225_numbered.png,2026-03-19 06:57:20.847024
4896,ML00003076,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NCCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003076_numbered.png,2026-03-19 06:57:20.923033
4897,ML00007845,,,C[C@H]1CC=C[C@@H](O)[C@@H](O)CCC(N=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 11]",ring_size_14/standard/numbered/ML00007845_numbered.png,2026-03-19 06:57:20.957642
4898,ML00004675,,,CCNNC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N/OCCCC3CCCCC3)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004675_numbered.png,2026-03-19 06:57:21.034535
4899,ML00005961,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](N(C)C2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005961_numbered.png,2026-03-19 06:57:21.108104
4900,ML00005903,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC/C=C/c2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2Cl)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005903_numbered.png,2026-03-19 06:57:21.170385
4901,ML00010615,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCCN)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010615_numbered.png,2026-03-19 06:57:21.234062
4902,ML00005917,,,C#CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)O[C@@H]3[C@@H](C)/C(=N/OC/C=C/c3cnc4ccccc4c3)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005917_numbered.png,2026-03-19 06:57:21.292290
4903,ML00010579,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(N)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010579_numbered.png,2026-03-19 06:57:21.347887
4904,ML00003818,,,COC1CC(C)OC(OC2C(C)CC(C)(O)C(=O)C(C)C(OC(C)=O)C(C)C(C(C)C(C)O)OC(=O)C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C2C)C1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003818_numbered.png,2026-03-19 06:57:21.408782
4905,ML00005845,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCOc3ccc4ccccc4c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00005845_numbered.png,2026-03-19 06:57:21.461255
4906,ML00008338,,,COc1cc(O)c2c(c1)CCCC(O)C(O)C(=O)/C=C/CC(C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008338_numbered.png,2026-03-19 06:57:21.492210
4907,ML00006039,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCCC(=O)NC(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006039_numbered.png,2026-03-19 06:57:21.556607
4908,ML00003111,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccc3ncccc3c2)[C@H](C)[C@@H]2OC(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003111_numbered.png,2026-03-19 06:57:21.613413
4909,ML00005630,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=N\OCc3cc(-c4cccc(OC)c4OC)no3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005630_numbered.png,2026-03-19 06:57:21.670582
4910,ML00007770,,,C/C1=C/CCC(C)C(C)OC(=O)CCC(C)(O)/C=C\C1=O,standard_macrolactone,14.0,,,success,,6.0,"[3, 4, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00007770_numbered.png,2026-03-19 06:57:21.707565
4911,ML00002548,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCCNCCCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002548_numbered.png,2026-03-19 06:57:21.764101
4912,ML00000008,CHEMBL532,ERYTHROMYCIN,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000008_numbered.png,2026-03-19 06:57:21.827995
4913,ML00007449,,,O=C1CC=C(C2=C(O)C(=O)O[C@]23Cc2ccc(cc2)Oc2cc(ccc2O)CCOC3=O)C=CO1,non_standard_macrocycle,14.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
4914,ML00002779,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(=O)OC)[C@H](C)C(OC/C(=C\C=C\c3ccccc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002779_numbered.png,2026-03-19 06:57:21.890828
4915,ML00005786,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005786_numbered.png,2026-03-19 06:57:21.954635
4916,ML00004275,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cccc(OC)c2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004275_numbered.png,2026-03-19 06:57:22.021863
4917,ML00010216,,,CC[C@@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@H](N(C)C)[C@H]2O)[C@H](C)C[C@@H](C)C(=O)CC[C@]1(C)O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010216_numbered.png,2026-03-19 06:57:22.082954
4918,ML00008474,,,COc1cc(O)c2c(c1OC)/C=C\C[C@H](O)[C@@H](O)C(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008474_numbered.png,2026-03-19 06:57:22.121459
4919,ML00005228,,,CCCCCCCCCCNNC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N/OCCCC3CCCCC3)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005228_numbered.png,2026-03-19 06:57:22.199181
4920,ML00006275,,,CCC(=O)O[C@H]1[C@@H](C)O[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](CC)C(C)(C)[C@H](O)[C@H](O)C(=O)[C@@H](C)C[C@@](C)(O[C@@H]3C[C@@H](N(C)C)[C@H](O)[C@@H](C)O3)[C@@H](O[C@H]3O[C@H](C)C[C@H](N(C)C)[C@@H]3O)[C@@H]2C)C[C@]1(C)OC(C)=O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006275_numbered.png,2026-03-19 06:57:22.278830
4921,ML00003796,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)C(O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCOc2ccccc2OC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003796_numbered.png,2026-03-19 06:57:22.354479
4922,ML00010488,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4923,ML00005769,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC(=O)COc3cc(N=[N+]=[N-])ccc3CO)[C@H]2O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005769_numbered.png,2026-03-19 06:57:22.441059
4924,ML00006737,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3ccc(Cl)cc3)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00006737_numbered.png,2026-03-19 06:57:22.473234
4925,ML00002611,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002611_numbered.png,2026-03-19 06:57:22.553740
4926,ML00002724,,,CCC#CCCCCCCCCN1C(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]12,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002724_numbered.png,2026-03-19 06:57:22.615069
4927,ML00004224,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccc(O)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004224_numbered.png,2026-03-19 06:57:22.678942
4928,ML00001680,CHEMBL1094225,,C[C@@H]1OC(=O)c2c(O)cc(OCCN(C)C)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001680_numbered.png,2026-03-19 06:57:22.717597
4929,ML00002584,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCc3ccc(N)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002584_numbered.png,2026-03-19 06:57:22.778565
4930,ML00004666,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4ccc(N)nc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004666_numbered.png,2026-03-19 06:57:22.843246
4931,ML00004810,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2cccc(NC(=O)Cc3ccccn3)n2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004810_numbered.png,2026-03-19 06:57:22.914147
4932,ML00002792,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)N[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002792_numbered.png,2026-03-19 06:57:22.983043
4933,ML00004262,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCC(=O)NCCc2ccccc2Cl)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004262_numbered.png,2026-03-19 06:57:23.051809
4934,ML00006054,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC(O)CNCCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006054_numbered.png,2026-03-19 06:57:23.128126
4935,ML00003314,,,CC(=O)OC[C@]12[C@H](O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4936,ML00009355,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4937,ML00009369,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(O)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N)C2OC)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009369_numbered.png,2026-03-19 06:57:23.217463
4938,ML00004300,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](CNCc2ccccc2)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004300_numbered.png,2026-03-19 06:57:23.277789
4939,ML00004502,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNCc2ccccc2[N+](=O)[O-])[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004502_numbered.png,2026-03-19 06:57:23.345874
4940,ML00004539,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCCCNc3ccc4c(=O)c(C(=O)O)cn(C5CC5)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004539_numbered.png,2026-03-19 06:57:23.420154
4941,ML00007737,,,C[C@H]1C[C@@H]2O[C@H]2CC/C=C\C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007737_numbered.png,2026-03-19 06:57:23.448893
4942,ML00004840,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cncc(NC(=O)Cc3ccccn3)c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004840_numbered.png,2026-03-19 06:57:23.516949
4943,ML00006906,,,C=C1/C=C(/C)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@](O)(CO)C/C(C)=C\[C@@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00006906_numbered.png,2026-03-19 06:57:23.568903
4944,ML00005268,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNCc2ccccc2OC)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005268_numbered.png,2026-03-19 06:57:23.637073
4945,ML00005847,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccc2F)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccccc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005847_numbered.png,2026-03-19 06:57:23.702587
4946,ML00004356,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NC/C=C/c3cccc4ccccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004356_numbered.png,2026-03-19 06:57:23.755640
4947,ML00010608,,,CC1CCCC(=O)CCCC=Cc2cc(OCc3ccc(Cl)cc3Cl)cc(OCc3ccc(Cl)cc3Cl)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010608_numbered.png,2026-03-19 06:57:23.780836
4948,ML00010724,,,C=CCO[C@]1(C)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010724_numbered.png,2026-03-19 06:57:23.842619
4949,ML00005826,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C/C=C/Cn3cnc(-c4cccnc4)c3)C(=O)N(C)[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00005826_numbered.png,2026-03-19 06:57:23.902390
4950,ML00003571,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3ccc(O)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003571_numbered.png,2026-03-19 06:57:23.958115
4951,ML00003001,,,CC(=O)OCC12C(OC(C)=O)C(OC(C)=O)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)OC(C(OC(C)=O)C2OC(=O)c1ccccc1)C4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4952,ML00009443,,,CC[C@@H]1OC(=O)[C@@H](C)[C@@H](O[C@@H]2C[C@H](OC)[C@@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@](C)(O)C(=O)[C@@H](C)[C@@H](O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 5, 6, 7, 8, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009443_numbered.png,2026-03-19 06:57:24.030649
4953,ML00005644,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCc3ccc(-c4ccncc4)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005644_numbered.png,2026-03-19 06:57:24.089488
4954,ML00008909,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C(C)C)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00008909_numbered.png,2026-03-19 06:57:24.142661
4955,ML00009551,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@H]2C[C@@H](N(C)C)C[C@@H](C)O2)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009551_numbered.png,2026-03-19 06:57:24.207716
4956,ML00009014,,,CO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@]3(CO3)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009014_numbered.png,2026-03-19 06:57:24.268228
4957,ML00006178,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006178_numbered.png,2026-03-19 06:57:24.340187
4958,ML00005949,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)N(C)N(C)CCc2ccc(-c3cnccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005949_numbered.png,2026-03-19 06:57:24.408896
4959,ML00003947,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4960,ML00008736,,,COc1cc(O)c2c(c1Br)C(=O)OCCCCC(=S)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4961,ML00003583,,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003583_numbered.png,2026-03-19 06:57:24.492851
4962,ML00002269,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCn1ccc2ccccc21,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002269_numbered.png,2026-03-19 06:57:24.554576
4963,ML00005872,,,C=C[C@]12OC(=O)N(CCCCn3cnc(-c4cnc(OC)nc4)c3)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005872_numbered.png,2026-03-19 06:57:24.622323
4964,ML00009739,,,CO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009739_numbered.png,2026-03-19 06:57:24.691035
4965,ML00010817,,,CC(C)COc1cccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)c1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010817_numbered.png,2026-03-19 06:57:24.719344
4966,ML00008674,,,C[C@@H]1C[C@H]2C[C@@H]2/C=C\C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00008674_numbered.png,2026-03-19 06:57:24.748784
4967,ML00006036,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006036_numbered.png,2026-03-19 06:57:24.824542
4968,ML00006476,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006476_numbered.png,2026-03-19 06:57:24.899817
4969,ML00000637,CHEMBL1651522,,COc1cc(O)c2c(c1)CCC[C@H](O)CC(=O)/C=C/C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,3.0,"[3, 7, 9]",ring_size_14/standard/numbered/ML00000637_numbered.png,2026-03-19 06:57:24.929184
4970,ML00003483,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2N(NCCc3ccccc3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003483_numbered.png,2026-03-19 06:57:24.985280
4971,ML00002367,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=N\OCC#Cc3cccc(N)n3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002367_numbered.png,2026-03-19 06:57:25.042957
4972,ML00009714,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4973,ML00003120,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4ccnc5ccccc45)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003120_numbered.png,2026-03-19 06:57:25.107413
4974,ML00004820,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2cncc(NC(=O)Cc3ccccn3)c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004820_numbered.png,2026-03-19 06:57:25.184264
4975,ML00006388,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006388_numbered.png,2026-03-19 06:57:25.249313
4976,ML00003524,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C(C)=O)[C@@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003524_numbered.png,2026-03-19 06:57:25.337383
4977,ML00001237,CHEMBL1778049,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001237_numbered.png,2026-03-19 06:57:25.402436
4978,ML00001846,CHEMBL3922219,,C[C@@H]1OC(=O)c2c(O)cc(N3CCOC3=O)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001846_numbered.png,2026-03-19 06:57:25.437213
4979,ML00010086,,,C/C1=C/C/C=C\C/C(CC(=O)O)=C\C(=O)O[C@@H](C[C@H](O)CC/C(C)=C/Cc2ccccc2)C[C@H](O)C1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 7, 13]",ring_size_14/standard/numbered/ML00010086_numbered.png,2026-03-19 06:57:25.468350
4980,ML00003135,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2cnc3ccccc3c2)C[C@@H](C)/C(=N\OC)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003135_numbered.png,2026-03-19 06:57:25.525251
4981,ML00001857,CHEMBL1095513,,CCOc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001857_numbered.png,2026-03-19 06:57:25.559431
4982,ML00009776,,,CC(=O)OCC12C(OC(C)=O)C(=O)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)OC(C(OC(C)=O)C2OC(C)=O)C4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4983,ML00010252,,,COc1cc(OC)cc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)c1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010252_numbered.png,2026-03-19 06:57:25.591038
4984,ML00003501,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccc(OC)cc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003501_numbered.png,2026-03-19 06:57:25.654081
4985,ML00009440,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009440_numbered.png,2026-03-19 06:57:25.721477
4986,ML00004823,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](OC(=O)c3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004823_numbered.png,2026-03-19 06:57:25.799352
4987,ML00009262,,,COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)/C2=C\COC(=O)CC3C(C(=O)OC)=COC(OC4OC(CO)C(O)C(O)C4O)/C3=C/COC(=O)CC12,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4988,ML00003292,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC/C(=N\Oc3cccnc3)CCO[C@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]3NC(=O)O[C@]13C)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 7, 8, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003292_numbered.png,2026-03-19 06:57:25.861242
4989,ML00005528,,,CCCCCCCCCCN1CCCC(O/N=C2/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@H]2C)C1,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005528_numbered.png,2026-03-19 06:57:25.926460
4990,ML00009660,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4991,ML00006419,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCC(=O)NC(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006419_numbered.png,2026-03-19 06:57:26.002247
4992,ML00009554,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009554_numbered.png,2026-03-19 06:57:26.068080
4993,ML00007415,,,CC[C@@H](/C=C(/C)[C@H]1C[C@H](OC)C[C@@H](O)C(C)(C)[C@]2(O)O[C@@H](C[C@H](OC)[C@@H]2O)C[C@H](OC)[C@@H](O)C(=O)O1)CO,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4994,ML00003018,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4995,ML00006016,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)C(C)C)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@@H](C)[C@@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4996,ML00008368,,,COc1cc(O)c2c(c1)/C=C/CCC[C@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00008368_numbered.png,2026-03-19 06:57:26.115444
4997,ML00002200,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2ccnc3ccccc23)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002200_numbered.png,2026-03-19 06:57:26.175958
4998,ML00002959,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C(=O)CNCCC(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002959_numbered.png,2026-03-19 06:57:26.252140
4999,ML00006335,,,CC(=O)OC[C@]12[C@@H](OC(C)=O)[C@H](OC(=O)c3cccnc3)[C@H]3OC(=O)[C@H](C)[C@@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@]1([C@H](OC(=O)c1ccccc1)[C@@H]4[C@@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5000,ML00001223,CHEMBL1256558,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001223_numbered.png,2026-03-19 06:57:26.331303
5001,ML00007571,,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1cccc(O)c1)CC(=O)O3,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007571_numbered.png,2026-03-19 06:57:26.361174
5002,ML00007064,,,CC(C)[C@@]1(O)CC(=O)O[C@H](C)[C@@](O)(C(C)C)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5003,ML00007808,,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C/C(=O)Cc2c(Br)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007808_numbered.png,2026-03-19 06:57:26.399206
5004,ML00006122,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N(CC)CC)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006122_numbered.png,2026-03-19 06:57:26.465584
5005,ML00001823,CHEMBL1446621,,C[C@H]1COC(=O)C/C=C\[C@@H](C)COC(=O)[C@H](C)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5006,ML00007939,,,C[C@@H]1C/C=C\CCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007939_numbered.png,2026-03-19 06:57:26.498813
5007,ML00001898,CHEMBL3895505,,CNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001898_numbered.png,2026-03-19 06:57:26.534789
5008,ML00005908,,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)O[C@@H]3[C@@H](C)/C(=N/OC/C=C/c3cnc4ccccc4c3)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005908_numbered.png,2026-03-19 06:57:26.595313
5009,ML00001845,CHEMBL1097653,,C[C@@H]1OC(=O)c2c(O)cc(N)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001845_numbered.png,2026-03-19 06:57:26.633998
5010,ML00009119,,,C=CCO[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009119_numbered.png,2026-03-19 06:57:26.700811
5011,ML00005240,,,CCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@](C)(OC)[C@H]2OC(=O)CCOCCOCCCc2ccc3c(c2)c(=O)c(C(=O)O)cn3CC)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005240_numbered.png,2026-03-19 06:57:26.771657
5012,ML00003855,,,CCCN[C@@H]1[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003855_numbered.png,2026-03-19 06:57:26.837518
5013,ML00004839,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N(CC)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004839_numbered.png,2026-03-19 06:57:26.897698
5014,ML00009445,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009445_numbered.png,2026-03-19 06:57:26.961902
5015,ML00006855,,,COc1cc2c(c(OCC(=O)NC(C)C)c1)C(=O)OC(C)CCCC(=O)CCCCC2,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00006855_numbered.png,2026-03-19 06:57:26.986815
5016,ML00003816,,,CCOC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003816_numbered.png,2026-03-19 06:57:27.051532
5017,ML00004407,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3ccc4c(c3)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004407_numbered.png,2026-03-19 06:57:27.117912
5018,ML00008732,,,COc1cc(O)c2c(c1C)C(=O)OCC(=S)NCC(=S)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5019,ML00000285,CHEMBL315521,,COc1ccc(NC(=O)CO/N=C2\C=C\C=C/[C@H]3O[C@@H]3C[C@@H](C)OC(=O)c3c(O)cc(O)c(Cl)c3C2)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00000285_numbered.png,2026-03-19 06:57:27.149432
5020,ML00006985,,,COc1cc(O)c2c(c1C)C(=O)OC[C@@H](CO)CCC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5021,ML00003942,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5022,ML00002188,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4cccc5nccnc45)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002188_numbered.png,2026-03-19 06:57:27.218180
5023,ML00001826,CHEMBL3909858,,C[C@H]1CCCCC[C@H](O)CC[C@H](O)/C=C/C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 9, 12]",ring_size_14/standard/numbered/ML00001826_numbered.png,2026-03-19 06:57:27.246269
5024,ML00007734,,,C[C@@H]1C[C@H]2O[C@@H]2C=CC=CC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007734_numbered.png,2026-03-19 06:57:27.271615
5025,ML00002891,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCC#Cc2cncnc2)[C@H](C)[C@@H](O[C@@H]2OCC[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2Cl)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002891_numbered.png,2026-03-19 06:57:27.329297
5026,ML00007765,,,C[C@@H]1C[C@H]2O[C@@H]2C[C@H](O)/C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 8, 11]",ring_size_14/standard/numbered/ML00007765_numbered.png,2026-03-19 06:57:27.358557
5027,ML00002976,,,CC(=O)OC[C@]12[C@H](OC(=O)c3ccccc3)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5028,ML00003620,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)/C(=N/O)C(C)C(O)C1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003620_numbered.png,2026-03-19 06:57:27.429739
5029,ML00003144,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCc1ccc(-c2cccnc2)s1,standard_macrolactone,14.0,,,success,,10.0,"[3, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003144_numbered.png,2026-03-19 06:57:27.483662
5030,ML00001728,CHEMBL3970354,,C[C@@H]1OC(=O)c2c(O)cc(NCCNCC(O)CO)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001728_numbered.png,2026-03-19 06:57:27.517413
5031,ML00009654,,,CC(=O)OCC12C(OC(C)=O)C(O)C3OC(=O)C(C)C(C)c4ncccc4C(=O)OCC4(C)OC1(C(OC(C)=O)C4C(OC(C)=O)C2OC(C)=O)C3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5032,ML00007953,,,C[C@@H]1C[C@H]2O[C@H]2CCCC[C@@H](O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007953_numbered.png,2026-03-19 06:57:27.549103
5033,ML00003479,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3ccc(OC)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003479_numbered.png,2026-03-19 06:57:27.601189
5034,ML00004251,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccc([N+](=O)[O-])cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004251_numbered.png,2026-03-19 06:57:27.653439
5035,ML00002144,,,C=CCO[C@@H]1C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)Cc2c[nH]c3ccccc23)[C@H](C)C1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002144_numbered.png,2026-03-19 06:57:27.709615
5036,ML00003029,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5037,ML00007913,,,C[C@@H]1C[C@@H](O)/C=C\[C@H](O)[C@@H](O)CC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,5.0,"[3, 5, 8, 9, 11]",ring_size_14/standard/numbered/ML00007913_numbered.png,2026-03-19 06:57:27.751736
5038,ML00003430,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2OC(=O)N3CC)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003430_numbered.png,2026-03-19 06:57:27.815629
5039,ML00006649,,,C/C1=C/CC[C@H](C)[C@@H](C)OC(=O)CC[C@](C)(O)/C=C\[C@@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O,standard_macrolactone,14.0,,,success,,6.0,"[3, 4, 8, 9, 12, 12]",ring_size_14/standard/numbered/ML00006649_numbered.png,2026-03-19 06:57:27.854084
5040,ML00001224,CHEMBL1778050,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001224_numbered.png,2026-03-19 06:57:27.917095
5041,ML00001053,CHEMBL3334713,,C[C@H]1CCCCC/C=C/C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00001053_numbered.png,2026-03-19 06:57:27.942535
5042,ML00005599,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](OC(=O)NC3CCCCC3)[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OC(=O)NC2CCCCC2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005599_numbered.png,2026-03-19 06:57:28.001402
5043,ML00009681,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5044,ML00008360,,,COc1cc(O)c2c(c1)/C=C\C[C@H](O)[C@H](O)[C@@H](O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008360_numbered.png,2026-03-19 06:57:28.039821
5045,ML00002783,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002783_numbered.png,2026-03-19 06:57:28.099015
5046,ML00004844,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCCC(=O)NCc3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004844_numbered.png,2026-03-19 06:57:28.164944
5047,ML00003765,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00003765_numbered.png,2026-03-19 06:57:28.218035
5048,ML00008991,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\O[C@@H]2CCCNC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00008991_numbered.png,2026-03-19 06:57:28.282284
5049,ML00003484,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](CNCc2ccccc2)[C@H]2N(C)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003484_numbered.png,2026-03-19 06:57:28.341501
5050,ML00005620,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005620_numbered.png,2026-03-19 06:57:28.406598
5051,ML00006573,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006573_numbered.png,2026-03-19 06:57:28.472214
5052,ML00007753,,,C[C@H]1C/C=C\CC/C=C\C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007753_numbered.png,2026-03-19 06:57:28.497876
5053,ML00000133,CHEMBL1328576,,CC[C@@H]1OC(=O)[C@H](C)[C@H](O[C@@H]2C[C@](C)(OC)[C@H](O)[C@H](C)O2)[C@H](C)[C@H](O[C@@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@H](C)C(=O)[C@H](C)[C@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000133_numbered.png,2026-03-19 06:57:28.561852
5054,ML00002939,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccco4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccco1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5055,ML00008718,,,COc1cc(O)c2c(c1Br)C(=O)OCCN(C)CC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5056,ML00004795,,,CCCNNC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N/OCCCC3CCCCC3)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004795_numbered.png,2026-03-19 06:57:28.640827
5057,ML00004479,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(-c5ccc(C(F)(F)F)cc5)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004479_numbered.png,2026-03-19 06:57:28.707365
5058,ML00007400,,,CC[C@@H]1/C=C\[C@H]([C@H](C)O)OC(=O)[C@@]2(C)C=CC(=O)NC3=C2C(=O)c2c(cc(C)c(O)c2C(=O)CC1)C3=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 6, 9, 12, 14]",ring_size_14/standard/numbered/ML00007400_numbered.png,2026-03-19 06:57:28.743668
5059,ML00004387,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3ccc4c(=O)c(C(=O)O)cn(CC)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004387_numbered.png,2026-03-19 06:57:28.811492
5060,ML00010621,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010621_numbered.png,2026-03-19 06:57:28.869378
5061,ML00008990,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\O[C@H]2CCCNC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00008990_numbered.png,2026-03-19 06:57:28.933452
5062,ML00009799,,,C=C1NC[C@H](C)[C@H](CC[C@@H](C)C(=O)/C=C\C(C)=C\CC[C@@H](C)CCCCCC)OC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](C)CNC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5063,ML00006910,,,C=C1/C=C(\C)[C@H](CC)OC(=O)[C@H](C)C(=O)[C@@](O)(CO)C/C(SC)=C/[C@@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 12, 12, 13, 14]",ring_size_14/standard/numbered/ML00006910_numbered.png,2026-03-19 06:57:28.987445
5064,ML00001382,CHEMBL1778055,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001382_numbered.png,2026-03-19 06:57:29.051809
5065,ML00006984,,,COc1cc(O)c2c(c1C)C(=O)O[C@H](CO)CCCC(=S)N[C@H](c1nc(CO)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5066,ML00007974,,,C[C@@H]1C/C=C/CC/C=C/[C@@H](O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 11]",ring_size_14/standard/numbered/ML00007974_numbered.png,2026-03-19 06:57:29.084515
5067,ML00002443,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2OC[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cc(-c4ccccn4)nn3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002443_numbered.png,2026-03-19 06:57:29.140923
5068,ML00008341,,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)[C@H](O)/C=C/C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008341_numbered.png,2026-03-19 06:57:29.172430
5069,ML00004290,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2C(NC(=O)CCc3ccncc3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004290_numbered.png,2026-03-19 06:57:29.228341
5070,ML00007708,,,C[C@H]1C[C@H]2O[C@@H]2C[C@H](O)/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 8, 11]",ring_size_14/standard/numbered/ML00007708_numbered.png,2026-03-19 06:57:29.256739
5071,ML00010238,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010238_numbered.png,2026-03-19 06:57:29.315265
5072,ML00006994,,,COc1cc(O)c2c(c1Br)C(=O)OCCN(C(=O)[C@H](C)N)CC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5073,ML00002572,,,CCC(=O)O[C@H]1[C@H](C)C(=O)[C@@]2(CO2)C[C@@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](C)[C@H](O[C@@H]2C[C@@H](OC)[C@H](OC(=O)CC)[C@@H](C)O2)[C@@H](C)C(=O)O[C@@H](C)[C@@H]1C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002572_numbered.png,2026-03-19 06:57:29.376380
5074,ML00005267,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNCc2ccc(OC)cc2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005267_numbered.png,2026-03-19 06:57:29.445125
5075,ML00010224,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010224_numbered.png,2026-03-19 06:57:29.498313
5076,ML00004234,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004234_numbered.png,2026-03-19 06:57:29.552010
5077,ML00006423,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006423_numbered.png,2026-03-19 06:57:29.621091
5078,ML00002366,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCC#Cc3ccc(N)nc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002366_numbered.png,2026-03-19 06:57:29.678460
5079,ML00009557,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009557_numbered.png,2026-03-19 06:57:29.744114
5080,ML00001208,CHEMBL1256536,,C=C(C)CN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](O[C@@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)[C@@H](O)[C@H](C)C[C@@]2(C)O)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00001208_numbered.png,2026-03-19 06:57:29.810609
5081,ML00006146,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OCCNCCCOCCCNCc2cnc3ccccc3c2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00006146_numbered.png,2026-03-19 06:57:29.876248
5082,ML00003337,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003337_numbered.png,2026-03-19 06:57:29.941588
5083,ML00009588,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cncnc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00009588_numbered.png,2026-03-19 06:57:30.005718
5084,ML00006926,,,CC[C@]1(O)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC(=O)[C@@](O)(C(C)C)CC(=O)O[C@@H]1C)[C@@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5085,ML00008720,,,COc1cc(O)c2c(c1Cl)C(=O)OCCCCC(=S)N[C@H](c1nc(CN)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5086,ML00003629,,,CC(=O)OCC12C(OC(C)=O)C(OC(C)=O)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)OC(C(OC(C)=O)C2OC(C)=O)C4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5087,ML00002166,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCCCc2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002166_numbered.png,2026-03-19 06:57:30.082151
5088,ML00010270,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@H](OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00010270_numbered.png,2026-03-19 06:57:30.140682
5089,ML00002873,,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NCCOCc2ccc(-c3ncccn3)cc2)C[C@@H](C)/C(=N\O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/ML00002873_numbered.png,2026-03-19 06:57:30.200922
5090,ML00007883,,,C[C@H]1CCC[C@H](O)CC/C=C\Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007883_numbered.png,2026-03-19 06:57:30.225227
5091,ML00000056,CHEMBL564085,TROLEANDOMYCIN,CO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](OC(C)=O)[C@@H](C)C(=O)[C@]3(CO3)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3OC(C)=O)[C@H]2C)O[C@@H](C)[C@@H]1OC(C)=O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 5, 6, 7, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000056_numbered.png,2026-03-19 06:57:30.280293
5092,ML00002150,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=C/c2ccc3ccccc3n2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002150_numbered.png,2026-03-19 06:57:30.337023
5093,ML00003948,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5094,ML00007926,,,C[C@@H]1C[C@@H]2O[C@@H]2C[C@@H](O)CCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,success,,3.0,"[3, 8, 11]",ring_size_14/standard/numbered/ML00007926_numbered.png,2026-03-19 06:57:30.372862
5095,ML00003286,,,C#CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3ccccn3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003286_numbered.png,2026-03-19 06:57:30.436029
5096,ML00004097,,,CC(=O)O[C@H]1[C@@H](O)[C@@H]2OC(=O)C(C)C(C)c3ncccc3C(=O)OC[C@]3(C)O[C@@]4([C@H](OC(C)=O)[C@H]3[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@]14OC(=O)c1ccccc1)[C@@]2(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5097,ML00008339,,,COc1cc(O)c2c(c1)CCC[C@@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,4.0,"[3, 7, 8, 9]",ring_size_14/standard/numbered/ML00008339_numbered.png,2026-03-19 06:57:30.474131
5098,ML00010185,,,COc1cc(OC)cc(C2CC(=O)Oc3cc4c(c(OC)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)c1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010185_numbered.png,2026-03-19 06:57:30.499222
5099,ML00004988,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)CCC(=O)NCCOCCOCCOCCNC(=O)CCCCCCCCCCSC)[C@](C)(O)C[C@@H](C)C(NOCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004988_numbered.png,2026-03-19 06:57:30.564323
5100,ML00008012,,,CC1CCCCCCCCCCCC(=O)O1,standard_macrolactone,14.0,,,success,,1.0,[3],ring_size_14/standard/numbered/ML00008012_numbered.png,2026-03-19 06:57:30.585397
5101,ML00002900,,,CCCCCNC(=O)O/N=C1/[C@H](C)[C@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](OC(=O)NCCCCC)[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002900_numbered.png,2026-03-19 06:57:30.641526
5102,ML00005880,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCCNCCCc2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005880_numbered.png,2026-03-19 06:57:30.697874
5103,ML00000894,CHEMBL376906,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](NC(=O)CCC2=CC3=Cc4c(C)cc(C)n4[B-](F)(F)[N+]3=C2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00000894_numbered.png,2026-03-19 06:57:30.763879
5104,ML00010511,,,COc1ccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1OCC(C)C,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00010511_numbered.png,2026-03-19 06:57:30.789414
5105,ML00007396,,,COc1ccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1,standard_macrolactone,14.0,,,success,,2.0,"[3, 7]",ring_size_14/standard/numbered/ML00007396_numbered.png,2026-03-19 06:57:30.814472
5106,ML00004814,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(-c5ccc([N+](=O)[O-])cc5)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004814_numbered.png,2026-03-19 06:57:30.881051
5107,ML00001708,CHEMBL1095164,,CC(C)Oc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 8, 9]",ring_size_14/standard/numbered/ML00001708_numbered.png,2026-03-19 06:57:30.916533
5108,ML00004163,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(=O)NC)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00004163_numbered.png,2026-03-19 06:57:30.980969
5109,ML00002158,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2ccc3[nH]ccc3c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00002158_numbered.png,2026-03-19 06:57:31.039040
5110,ML00007489,,,O=C1CCC2=C1[C@@H](O)OC1=C2[C@@]2(Cc3ccc(cc3)Oc3cc(cc(O)c3O)CCOC2=O)OC1=O,non_standard_macrocycle,14.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5111,ML00005794,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=N/Nc2ccccn2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00005794_numbered.png,2026-03-19 06:57:31.112489
5112,ML00003658,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(=O)[C@H](C)[C@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@]1([C@H](OC(C)=O)[C@@H]4[C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5113,ML00003766,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003766_numbered.png,2026-03-19 06:57:31.184446
5114,ML00004287,,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3cccc([N+](=O)[O-])c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/ML00004287_numbered.png,2026-03-19 06:57:31.238098
5115,ML00003117,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=C\C#Cc3ccccc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/ML00003117_numbered.png,2026-03-19 06:57:31.294845
5116,ML00000219,CHEMBL1774639,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCN(CCC#N)C(=S)NCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5117,ML00001107,CHEMBL3774592,,C=C1/C=C/C(=O)N(C)CC(=O)N[C@@H]([C@H](O)C(N)=O)C(=O)O[C@@H]([C@H](C)CCCCCCCCCCCCC(C)C)[C@H](C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5118,ML00001761,CHEMBL89179,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCc2cccnc2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5119,ML00002040,CHEMBL89747,,CCOC(=O)N1CCN(C(=O)CNC(=O)[C@@H]2CCCCN(C)C(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N2)CC1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5120,ML00000958,CHEMBL2029743,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2ccc3ccccc3n2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5121,ML00003950,,,CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H]2[C@@H](OC(C)=O)[C@@]34O[C@@]2(C)COC(=O)c2cccnc2CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c2ccccc2)[C@H](OC(C)=O)[C@@]13CO)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5122,ML00008825,,,CC(C)[C@@H]1OC(=O)C(C)(C)[C@@H](O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](C(C)C)OC(=O)[C@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5123,ML00002565,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCCCc2ccccn2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5124,ML00002563,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5125,ML00003846,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5126,ML00001954,CHEMBL4068622,,C=C1/C=C/C(=O)N[C@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCOC(=O)CP(=O)(OCC)OCC)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5127,ML00010520,,,CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)OC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(I)cc2)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5128,ML00003644,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CCC(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5129,ML00001004,CHEMBL3218564,,CCCC[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)N[C@H](CC(C)C)[C@@H](O)CC(=O)O2,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5130,ML00002962,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(C#CCN(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5131,ML00001222,CHEMBL1774293,,CCNC(=O)N1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5132,ML00004607,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccccc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccncc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5133,ML00003912,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(Cc4ccncc4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5134,ML00005311,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccc(C)cc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5135,ML00005556,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2OC(=Nc2ccc(OC)cc2)N3C)[C@](C)(OC)C[C@@H](C)C(=O)N[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5136,ML00005465,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNCCCNCCOCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5137,ML00007515,,,CO/C1=C(/C(C)C)CC/C=C(/C)C2OC(C)(O)C3C(=O)O/C(=C(/C)CCC(C)OC1=O)C23,standard_macrolactone,15.0,,,success,,5.0,"[3, 6, 10, 14, 15]",ring_size_15/standard/numbered/ML00007515_numbered.png,2026-03-19 06:57:31.478960
5138,ML00004008,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(=O)c3ccccc3)[C@@H]3OC(=O)[C@@H](C)CCc4ncccc4C(=O)OC[C@]4(C)O[C@]1([C@H](O)[C@@H]4[C@@H](OC(C)=O)[C@H]2OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5139,ML00003962,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5140,ML00003984,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]3[C@@H](OC(C)=O)[C@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@H](C)C(=O)O[C@H]([C@@H](OC(=O)c1ccco1)[C@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5141,ML00001734,CHEMBL89034,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCOCC2)CCCCN(C)C(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5142,ML00005967,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CN(CC)CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)N[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5143,ML00005245,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccc(C)cc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(OC)cc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5144,ML00009947,,,CC[C@H](C)[C@@H]1OC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)C/C(C)=C\[C@H](C)[C@@H](O)/C(C)=C\[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5145,ML00001538,CHEMBL3601578,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(Cc2ccc(-c3cn(CCn4ccc5cc([N+](=O)[O-])ccc54)nn3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5146,ML00005230,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCNc3cc4c(=O)c(C(=O)OC(C)C)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5147,ML00008680,,,COc1c(Br)cc2cc1Oc1ccc(cc1)CC(O)COC(=O)CC2,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5148,ML00003187,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(OC(C)=O)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5149,ML00000220,CHEMBL553625,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=S)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5150,ML00004397,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccc(F)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2Cl)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5151,ML00005352,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNCCCNCCOCCOCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5152,ML00006025,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(OC(C)=O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5153,ML00002898,,,CC[C@@H]1CCC(=O)O[C@H]2[C@H](C)[C@@]34O[C@](C)(COC(=O)c5cccnc51)[C@@H]([C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]3(COC(C)=O)[C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@@H]4OC(C)=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5154,ML00002505,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccco1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5155,ML00001109,CHEMBL3775644,,C=C1/C=C/C(=O)N(C)CC(=O)N[C@H]([C@@H](O)C(=O)OC)C(=O)O[C@@H]([C@H](C)CCCCCCCCCCCC(C)C)[C@H](C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5156,ML00000410,CHEMBL1682468,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(Cl)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5157,ML00006151,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN(C)C[C@H](COc3ccc(-c4cccnc4)cc3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5158,ML00003530,,,CC(C)C[C@@H]1OC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5159,ML00000554,CHEMBL1682595,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NC2CC3C=CC2C3)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5160,ML00003036,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CN(CCO)CCO)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5161,ML00000212,CHEMBL539222,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=S)NCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5162,ML00001760,CHEMBL313936,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCCc2ccccn2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5163,ML00000224,CHEMBL557551,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5164,ML00001435,CHEMBL553222,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5165,ML00003932,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCc2ccccc2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5166,ML00005395,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCOc3cc4c(=O)c(C(=O)OCOC(=O)C(C)(C)C)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5167,ML00004366,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCO[C@@H]3O[C@H](CO)[C@@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5168,ML00005433,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCCc3cc4c5c(c3)c(=O)c(C(=O)O)cn5C(C)(C)CO4)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5169,ML00001914,CHEMBL3775914,,COC(=O)[C@H](O)[C@H]1NC(=O)CN(C)C(=O)/C=C/[C@@H](CO)NC(=O)[C@H](C)[C@@H]([C@@H](C)CCCCCCCCCCCC(C)C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5170,ML00003037,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CNC(C)(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5171,ML00003084,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NC(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5172,ML00002061,CHEMBL431008,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCN(C)CC2)CCCCN(C)C(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5173,ML00005554,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCN2CCN(c3ccc(F)cc3)CC2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5174,ML00001737,CHEMBL315276,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCN(C)CC2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5175,ML00005799,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4cccc(OC)c4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5176,ML00000450,CHEMBL1682576,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccccc2F)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5177,ML00006515,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5178,ML00002712,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4cc5ccccc5[nH]4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5179,ML00000415,CHEMBL1682465,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2cccc3nsnc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5180,ML00005459,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@@]2(O)[C@@H](C)C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(Cl)[C@@H](O)C[C@@]32C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5181,ML00000414,CHEMBL1682451,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2cccc3nsnc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5182,ML00000384,CHEMBL3352926,,C=C1/C=C/C(=O)N(C)CC(=O)NC(C(O)C(N)=O)C(=O)OC(C(C)CCCCCCCCCCCCC(C)C)C(C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5183,ML00001248,CHEMBL350938,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](Cc3ccccc3)NC2=O)cc1Cl,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5184,ML00001441,CHEMBL2029761,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Cc2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5185,ML00003886,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4cccnc4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5186,ML00000965,CHEMBL2029589,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNc2ccnc3cc(Cl)ccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5187,ML00005324,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3cc([N+](=O)[O-])cc([N+](=O)[O-])c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(F)c(F)c2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5188,ML00006282,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccccc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5189,ML00006297,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccccc4Cl)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5190,ML00000560,CHEMBL1682453,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc([N+](=O)[O-])cc2OC)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5191,ML00001632,CHEMBL541735,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=O)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5192,ML00007807,,,O=C1CCc2ccc(O)c(c2)Oc2ccc(cc2)[C@H]2O[C@@H]2CO1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5193,ML00003064,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCCCc2ccccc2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5194,ML00003322,,,CCC1OC(=O)C(C)[C@@H](O[C@H]2C[C@@](C)(OC)C(O)C(C)O2)C(C)[C@@H](O[C@@H]2OC(C)CC(N(C)C)C2O)[C@@](C)(O)CC(C)CN(C)C(C)C(O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5195,ML00005805,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCN(C)CCc2ccccc2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5196,ML00010524,,,CC(C)CC1NC(=O)C(C(C)C)NC(=O)C(CC(C)C)OC(=O)C(CC(C)C)NC(=O)C(Cc2ccccc2)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5197,ML00000955,CHEMBL2029585,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5198,ML00007264,,,C=C1CC[C@H](Br)[C@@]2(C)CC[C@@H](Br)[C@@](C)(O)CC[C@@H](C(C)(C)Br)OC(=O)c3ccc(O)c(c3)C[C@H]12,standard_macrolactone,15.0,,,success,,5.0,"[3, 6, 6, 7, 10]",ring_size_15/standard/numbered/ML00007264_numbered.png,2026-03-19 06:57:31.991489
5199,ML00004561,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccc(Br)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccc(OC)cc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5200,ML00001486,CHEMBL2029749,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2ccnc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5201,ML00001909,CHEMBL4072704,,CCCCCC[C@@H](C)[C@@H]1OC(=O)[C@H](C(C)C)NC(=O)[C@@H](C)NC(=O)/C=C/[C@H](CO)NC(=O)[C@H]1CCOCc1ccccc1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5202,ML00003848,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@](O)(CSCCO)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5203,ML00007617,,,CO/N=C/C=C/C(=O)N/C=C/C[C@@H]1CC(=O)O[C@@H](CO)/C=C\[C@@H](O)/C(C)=C\Cc2cccc(O)c2C(=O)O1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5204,ML00002057,CHEMBL88906,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCC(C(=O)O)CC2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5205,ML00001987,CHEMBL349460,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C(C)C)NC2=O)cc1Cl,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5206,ML00001609,CHEMBL509784,OPPOSITINE A,CCC1CCC(=O)O[C@H]2[C@H](OC(C)=O)[C@H](OC(=O)c3ccccc3)[C@@]3(COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]4[C@@H](OC(C)=O)[C@]3(O[C@]4(C)COC(=O)c3cccnc31)[C@@]2(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5207,ML00006526,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc(Cl)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5208,ML00001453,CHEMBL2314758,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@H]2[C@H](C)C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@@]32C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5209,ML00009694,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5210,ML00003631,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(=O)[C@H](C)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5211,ML00000506,CHEMBL1682447,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NC(c2ccccc2)c2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5212,ML00004902,,,COc1ccc(C[C@@H](C(=O)O[C@H](C)[C@H](NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](C)O)C(=O)N2CCCCNC(=O)[C@@H](C)C(=O)[C@H](C(C)C)OC(=O)C[C@H](O)[C@H]2CC(C)C)N(C)C(C)=O)cc1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5213,ML00001469,CHEMBL2029591,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNc2cc(C)nc3ccc(OC)cc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5214,ML00004523,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3ccc4c(=O)c(C(=O)O)cn(C5CC5)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5215,ML00000333,CHEMBL1774626,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCNC(=O)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5216,ML00006024,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(OC(C)=O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5217,ML00009784,,,CC[C@H](C)[C@H]1OC(=O)C(C)(C)[C@H](O)[C@H](Cc2ccccc2)OC(=O)[C@@H](C(C)C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5218,ML00004452,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3cccc4ccccc34)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5219,ML00004560,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccc(Cl)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccc(OC)cc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5220,ML00004505,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4N(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5221,ML00002507,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5222,ML00004476,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](N)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)OCC2c3ccccc3-c3ccccc32)[C@](C)(O)C[C@@H](C)N(CCF)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5223,ML00003451,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCc2cccnc2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5224,ML00000495,CHEMBL1682607,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NC(=O)c2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5225,ML00005323,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN(C)CCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5226,ML00004562,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4c(Cl)cccc4Cl)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5227,ML00003425,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ncccn4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5228,ML00001848,CHEMBL3358523,,C[C@H]1CCCC(=O)N(C)/C=C/CC[C@H](C)C(=O)O[C@H](C(C)(C)C)C1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5229,ML00009701,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5230,ML00002909,,,CCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]3OC(=O)O[C@]3(C)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5231,ML00003316,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](N)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5232,ML00007526,,,C/C=C\C/C=C/[C@H](C)C[C@H](O)[C@H]1C[C@@H]2O[C@H]2/C=C\[C@@H](O)[C@@H](O)/C=C\C[C@H](C)CC(=O)O1,standard_macrolactone,15.0,,,success,,4.0,"[3, 9, 10, 14]",ring_size_15/standard/numbered/ML00007526_numbered.png,2026-03-19 06:57:32.304459
5233,ML00008940,,,CC[C@H]1OC(=O)/C(C)=C\[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN(C(=O)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5234,ML00005476,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4ccc(NC(C)=O)cc4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5235,ML00000418,CHEMBL1682459,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(Cl)c(Cl)c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5236,ML00000467,CHEMBL4098570,,C=C1/C=C/C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)O[C@H]([C@@H](C)CCCCCC)[C@@H](CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5237,ML00007621,,,CO/N=C/C=C\C(=O)N/C=C/C[C@@H]1CC(=O)O[C@@H](C)/C=C\[C@@H](O)/C(C)=C\Cc2cccc(O)c2C(=O)O1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5238,ML00000878,CHEMBL2029763,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@H](C)c2ccc3cc(OC)ccc3c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5239,ML00009594,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C(=O)Nc2cccc(C(F)(F)F)c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5240,ML00007525,,,C/C=C/C/C=C\[C@H](C)C[C@H](O)[C@H]1C[C@@H]2O[C@H]2/C=C\[C@@H](O)[C@@H](O)/C=C\C[C@H](C)CC(=O)O1,standard_macrolactone,15.0,,,success,,4.0,"[3, 9, 10, 14]",ring_size_15/standard/numbered/ML00007525_numbered.png,2026-03-19 06:57:32.383963
5241,ML00008722,,,C[C@@H]1CC=CCCCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,15.0,,,success,,2.0,"[3, 12]",ring_size_15/standard/numbered/ML00008722_numbered.png,2026-03-19 06:57:32.408622
5242,ML00000576,CHEMBL1682467,,CCOC(=O)c1ccc(NC(=S)NCCCN2C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]2C)cc1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5243,ML00004359,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)(CN(C)Cc3ccc(-c4cn(CCCCC(=O)NO)nn4)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5244,ML00009760,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5245,ML00003825,,,C=CCN1C(=O)O[C@H]2[C@H](O[C@@H]3[C@@H](C)[C@H](O[C@H]4C[C@@](C)(OC)[C@@H](O)[C@H](C)O4)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@]3(C)O)O[C@H](C)C[C@@H]21,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5246,ML00000577,CHEMBL1682461,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccc3c(c2)CCC3)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5247,ML00000339,CHEMBL1773086,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5248,ML00000425,CHEMBL3822850,,COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc2ccc3cc(-c4ccc(-c5c[nH]c([C@@H]6C[C@@H]7CN6C(=O)[C@H](C(C)C)NC(=O)OCCC/C=C/CO7)n5)cc4)ccc3c2[nH]1)C(C)C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5249,ML00003085,,,CCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5250,ML00002671,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4ccccc4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5251,ML00004160,,,C=C[C@@]1(O)[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5252,ML00005331,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCC(=O)NCCOCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5253,ML00007614,,,CON1O/C=C\C=C(N)/C=C\C[C@@H]2CC(=O)O[C@H](CO)/C=C\[C@@H](O)/C(C)=C\Cc3cccc(c3C(=O)O2)O1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5254,ML00004435,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCCNC(=O)CCCNc3ccnc4ccccc34)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5255,ML00000494,CHEMBL1682713,,C=CCNC(=S)NCCCN1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5256,ML00001219,CHEMBL1774291,,C=CCN1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5257,ML00002203,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccncc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5258,ML00003323,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C(N)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5259,ML00001852,CHEMBL3358522,,C[C@@H]1CCCC(=O)N(C)CCCC[C@@H](C)C(=O)O[C@@H](C(C)(C)C)C1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5260,ML00004401,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5261,ML00010757,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC2CO2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5262,ML00008576,,,CO[C@@H]1COC(=O)[C@H]2CCCN2C(=O)[C@@H](C)COC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5263,ML00001257,CHEMBL4095942,,C=C1/C=C/C(=O)N[C@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCOC(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5264,ML00005477,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5265,ML00009698,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5266,ML00000412,CHEMBL1682574,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2cccc(Cl)c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5267,ML00004079,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5268,ML00000512,CHEMBL1682581,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccccc2-c2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5269,ML00003817,,,CC#C[C@@]1(O)[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5270,ML00004597,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccco3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccc(OC)cc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5271,ML00002713,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4c[nH]c5ccccc45)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5272,ML00005269,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4N(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5273,ML00000698,CHEMBL1946558,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCCNc3ccnc4ccc(Cl)cc34)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5274,ML00004614,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCOc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5275,ML00000565,CHEMBL1682608,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(N(CC)CC)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5276,ML00005222,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCCCOCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5277,ML00004173,,,C#C[C@@]1(O)[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5278,ML00004565,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@H](n3cccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)OCC2c3ccccc3-c3ccccc32)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5279,ML00001052,CHEMBL1476850,,CO[C@@H]1/C=C\CC(=O)N2CCC[C@@H]2C(=O)OC[C@H](C)C(=O)OC[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5280,ML00005357,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCNc3cc4c(=O)c(C(=O)OCCN5CCCC5)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5281,ML00001450,CHEMBL3601455,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCCc2cn(CCc3c[nH]c4ccc(F)cc34)nn2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5282,ML00002503,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccco1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5283,ML00009738,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)CN(C)CCOC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5284,ML00006078,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ccc(C(=O)OCc5ccccc5)c(C(F)(F)F)c4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5285,ML00006544,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCNc2ccc3c(c2F)c(=O)c(C(=O)O)cn3C2CC2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5286,ML00009889,,,CC(C)C[C@@H]1OC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5287,ML00008044,,,O=C1CCCCCCCCCCCCCO1,standard_macrolactone,15.0,,,success,,0.0,[],ring_size_15/standard/numbered/ML00008044_numbered.png,2026-03-19 06:57:32.768696
5288,ML00003849,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CSCCO)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5289,ML00004796,,,CCCCNC(=O)O[C@@H]1[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccc(OC)cc3)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5290,ML00006385,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccc(F)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5291,ML00002552,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(Cc4cccnc4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5292,ML00001723,CHEMBL3126831,,CSCC[C@@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)N[C@@H](C(C)C)[C@H](O)CC(=O)O2,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5293,ML00003715,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2OC(=O)N3C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5294,ML00004443,,,CCCCCNC(=O)O[C@@H]1[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccccc3Cl)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5295,ML00005262,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNCCCNCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5296,ML00010445,,,CON1O/C=C\C=C(N)/C=C\C[C@@H]2CC(=O)O[C@H](COC(C)=O)/C=C\[C@@H](O)/C(C)=C\Cc3cccc(c3C(=O)O2)O1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5297,ML00008120,,,CO[C@H]1COC(=O)[C@H](C)COC(=O)[C@H](C)NC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5298,ML00002285,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4ccc(Cl)c(Cl)c4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5299,ML00004692,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3ccc(-c4cn(CCCCC(=O)NO)nn4)cc3)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5300,ML00003979,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccco1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5301,ML00001559,CHEMBL2029762,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Cc2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5302,ML00005512,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5303,ML00002932,,,CCCCCCN1C(=O)O[C@H]2[C@H](O[C@@H]3[C@@H](C)[C@H](O[C@H]4C[C@@](C)(OC)[C@@H](O)[C@H](C)O4)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@]3(C)O)O[C@H](C)C[C@@H]21,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5304,ML00001407,CHEMBL1774300,,C=CO[C@]1(C)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5305,ML00003068,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccc([N+](=O)[O-])cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN(C(=O)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5306,ML00004003,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3ccccc3)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5307,ML00005562,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CN2CCN(c3cnc4ccccc4c3)CC2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5308,ML00000562,CHEMBL1682463,,CCc1ccc(NC(=O)NCCCN2C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]2C)cc1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5309,ML00005353,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNCCCNCCOCCOCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5310,ML00010775,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5311,ML00001327,CHEMBL434475,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](CC(C)C)NC2=O)cc1Cl,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5312,ML00000290,CHEMBL1437314,,Cc1ccc(S(=O)(=O)N[C@H]2COC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](C)COC(=O)C/C=C\[C@@H]2C)cc1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5313,ML00002734,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4ccccc4OC)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5314,ML00005581,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN2/C(=N\Cc3ccccc3)O[C@H]([C@H]2C)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5315,ML00004529,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5316,ML00004544,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCC(=O)NCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5317,ML00004303,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN2/C(=N\c3cccc4ccccc34)O[C@H]([C@H]2C)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5318,ML00005467,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(OC)cc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5319,ML00005462,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCN3CCN(C/C=C/c4ccc5c(c4)c(=O)c(C(=O)O)cn5CC)CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5320,ML00005483,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=S)NCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5321,ML00010743,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5322,ML00010771,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5323,ML00000483,CHEMBL1682717,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)NC(C)(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5324,ML00002694,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCNc2cnc3ccccc3c2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5325,ML00003639,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5326,ML00008677,,,COc1ccc2cc1Oc1ccc(cc1)/C=C\COC(=O)CC2,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5327,ML00000567,CHEMBL1682705,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2cc(C(=O)OC)cc(C(=O)OC)c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5328,ML00001630,CHEMBL2029751,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCC(=O)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5329,ML00003611,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5330,ML00004644,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)CCN(CCCCc4ccccc4)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(C)=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5331,ML00001999,CHEMBL4061316,,CCCCCC[C@@H](C)[C@@H]1OC(=O)[C@H](C(C)C)NC(=O)[C@@H](C)NC(=O)/C=C/[C@H](CO)NC(=O)[C@H]1CCOCc1ccc(OC)cc1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5332,ML00000427,CHEMBL1682609,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2cc(C)oc2C(F)(F)F)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5333,ML00004511,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)(CN(C)C)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3ccc(-c4cn(CCCCCCC(=O)NO)nn4)cc3)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5334,ML00008968,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)C=C)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5335,ML00006217,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccccc4Cl)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5336,ML00006529,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc([N+](=O)[O-])cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5337,ML00006300,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc(OC)c(OC)c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5338,ML00005359,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccc(OC)c(OC)c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5339,ML00009315,,,O=C1NCCCC[C@@H](C(=O)NCC(=O)N2CCOCC2)NC(=O)[C@H](Cc2ccc(-c3ccccc3C(F)(F)F)cc2)[C@@H](C(=O)NO)CCCO1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5340,ML00000662,CHEMBL1436797,,Cc1ccc(S(=O)(=O)N[C@H]2COC(=O)[C@@H](C)COC(=O)[C@H](C)NC(=O)C/C=C\[C@H]2C)cc1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5341,ML00000187,CHEMBL1774631,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCNC(=O)Nc2ccc3ccccc3c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5342,ML00007265,,,CC1=CC[C@H](Br)[C@@]2(C)CC[C@@H](Br)[C@@](C)(O)CC[C@@H](C(C)(C)Br)OC(=O)c3ccc(O)c(c3)C[C@H]12,standard_macrolactone,15.0,,,success,,5.0,"[3, 6, 6, 7, 10]",ring_size_15/standard/numbered/ML00007265_numbered.png,2026-03-19 06:57:33.341739
5343,ML00005236,,,CCCOC(=O)c1cn(C2CC2)c2cc(Cl)c(NCCOCCC(=O)O[C@H]3[C@H](C)O[C@@H](O[C@H]4[C@H](C)[C@@H](O[C@@H]5O[C@H](C)C[C@H](N(C)C)[C@H]5O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]4C)C[C@@]3(C)OC)cc2c1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5344,ML00002863,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(c3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5345,ML00003512,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5346,ML00006243,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN(C)C[C@H](COc3cccc(-c4ccccc4)c3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5347,ML00003610,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5348,ML00006119,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ncc(C(=O)OCc5ccccc5)c(C(F)(F)F)n4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5349,ML00004643,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccc(Cl)cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5350,ML00004005,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5351,ML00003095,,,C=CCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5352,ML00003760,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)Nc2cccc(Cl)c2)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5353,ML00006290,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCNC(=O)c3ccc([N+](=O)[O-])cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5354,ML00000663,CHEMBL1378235,,CO[C@H]1COC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)COC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5355,ML00006150,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5356,ML00006520,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2cccc(C)c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(OC)cc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5357,ML00002391,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCc2ccc3ncccc3c2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5358,ML00010342,,,CON1O/C=C\C=C(N)/C=C\C[C@@H]2CC(=O)O[C@H](CO)/C=C\[C@@H](OC(C)=O)/C(C)=C\Cc3cccc(c3C(=O)O2)O1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5359,ML00007139,,,C[C@H]1CC[C@@H](C)C[C@@H](C)C(=O)N(C)/C=C\CC(=O)O[C@H](C(C)(C)C)C1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5360,ML00003410,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4ccoc4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5361,ML00001431,CHEMBL2029740,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2cccnc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5362,ML00004004,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5363,ML00002000,CHEMBL2029748,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2cnc3ccccc3c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5364,ML00005600,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)NC(C)c2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5365,ML00010134,,,CC(=O)OC[C@]12CC(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5366,ML00006549,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccc(F)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5367,ML00005561,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CN2CCN(c3ccc4ncccc4c3)CC2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5368,ML00003630,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5369,ML00005820,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4ccc5ccccc5n4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5370,ML00000959,CHEMBL2029746,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2cnc3ccccc3c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5371,ML00002980,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@H]4C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5372,ML00000352,CHEMBL325421,,O=C1NCCCC[C@@H](C(=O)NCC(=O)N2CCNCC2)NC(=O)[C@H](Cc2ccc(-c3cccc(C(F)(F)F)c3)cc2)[C@@H](C(=O)NO)CCCO1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5373,ML00004399,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccccc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(F)cc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5374,ML00000280,CHEMBL3774991,,C=C1/C=C/C(=O)N(C)CC(=O)N[C@@H]([C@H](O)C(N)=O)C(=O)O[C@@H]([C@H](C)CCCCCCCCCCCC(C)C)[C@H](C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5375,ML00000451,CHEMBL1682712,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)NCc2ccco2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5376,ML00004802,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)(CN(C)Cc3ccc(-c4cn(CCC(=O)NO)nn4)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5377,ML00000453,CHEMBL1682718,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2cccnc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5378,ML00006293,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN[C@@H](C)C(=O)Nc3ccc([N+](=O)[O-])cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5379,ML00000465,CHEMBL2041390,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OCCCNc2ccnc3cc(Cl)ccc23)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5380,ML00002647,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5381,ML00002209,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4cccnc4)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CCC(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5382,ML00003062,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4ccccc4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5383,ML00009474,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCC(C)C)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5384,ML00007619,,,CON1O/C=C\C=C(N)/C=C\C[C@H]2CC(=O)O[C@H](C)/C=C\[C@@H](O)/C(C)=C\Cc3cccc(c3C(=O)O2)O1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5385,ML00003063,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CN[C@H](C)Cc2ccc(OC)cc2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5386,ML00006257,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccc(Cl)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C2OC(=O)OC12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5387,ML00004700,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCNC(=O)c3ccc(OC)c(OC)c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5388,ML00000499,CHEMBL1945693,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCNCCOCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5389,ML00001537,CHEMBL3601577,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(Cc2ccc(-c3cn(CCn4ccc5cc(F)ccc54)nn3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5390,ML00001683,CHEMBL88284,,COC(=O)c1csc(NC(=O)[C@@H]2CCCCNC(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N2)n1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5391,ML00009763,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CC[C@](C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5392,ML00005257,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN(C)[C@@H](CN(c3cncc(-c4ccc(F)cc4)c3)c3cncc(-c4ccc(F)cc4)c3)COC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5393,ML00006590,,,CC[C@H](C)[C@H]1NC(=O)[C@H]2CSSCC/C=C\[C@H](CC(=O)N[C@H](CCSC)C(=O)N2)OC(=O)C[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5394,ML00003186,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5395,ML00005394,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCNc3cc4c(=O)c(C(=O)OCOC(=O)C(C)(C)C)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5396,ML00006576,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5397,ML00004739,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)OCCCN(CCCCc4ccccc4)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(C)=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5398,ML00001759,CHEMBL89755,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)Nc2ccccc2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5399,ML00004478,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3cccs3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccccc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5400,ML00004605,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccccc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccc(O)cc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5401,ML00001590,CHEMBL1811932,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5402,ML00002561,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(c3cccs3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5403,ML00003634,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5404,ML00003080,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)N(C)C[C@H](C)[C@@H](OC)[C@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5405,ML00006022,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1CC[C@@](C)(OC(=O)c1ccccc1)C(=O)O[C@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5406,ML00004893,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3cn(CCCNc4ccnc5cc(Cl)ccc45)nn3)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5407,ML00000892,CHEMBL2029594,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5408,ML00006727,,,O=C1CCc2ccc(OCc3ccccc3)c(c2)Oc2ccc(cc2)CCCO1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5409,ML00003203,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5410,ML00000555,CHEMBL1682709,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccc(OC)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5411,ML00004001,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5412,ML00002684,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4nc(C)ccc4C#N)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5413,ML00001147,CHEMBL324549,,CS(=O)(=O)c1ccccc1-c1ccc(C[C@H]2C(=O)N[C@H](C(=O)NCC(=O)N3CCOCC3)CCCCNC(=O)OCCC[C@@H]2C(=O)NO)cc1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5414,ML00009110,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C(=O)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5415,ML00006567,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(c3cc4ccccc4n3C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5416,ML00006216,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4cccc(Cl)c4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5417,ML00002901,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)[C@H](N)[C@H](C)CN(C)C[C@H](COCc3ccccc3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5418,ML00006219,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCNCCNc2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5419,ML00000622,CHEMBL1257966,CALLOPHYCOLIDE A,CC(C)=CCC[C@@](C)(O)[C@@H]1CC/C(C)=C/CC/C(C)=C/Cc2cc(ccc2O)C(=O)O1,standard_macrolactone,15.0,,,success,,3.0,"[3, 6, 10]",ring_size_15/standard/numbered/ML00000622_numbered.png,2026-03-19 06:57:33.981936
5420,ML00005204,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4CCN(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5421,ML00000391,CHEMBL3352925,,C=C1/C=C/C(=O)N(C)CC(=O)N[C@H]([C@@H](O)C(N)=O)C(=O)O[C@@H]([C@H](C)CCCCCCCCCCCC(C)C)[C@H](C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5422,ML00003930,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4occc4C)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5423,ML00004729,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCNC(=O)c3ccc(C)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5424,ML00005223,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5425,ML00006678,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5426,ML00002614,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(Cn3ccnc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5427,ML00003645,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5428,ML00004714,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccccc4C)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5429,ML00010151,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)c2ocnc2C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5430,ML00003241,,,CC(=O)OC[C@H]1[C@@H]2[C@H]3COC(=O)c4cccnc4CC[C@](C)(O)C(=O)O[C@@H]4[C@@H](OC(=O)c5ccc(=O)n(C)c5)[C@@H](OC(C)=O)[C@](COC(C)=O)([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]1(O3)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5431,ML00000874,CHEMBL2314996,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@@]2(O)[C@H](C)C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(Cl)[C@@H](O)C[C@@]32C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5432,ML00004541,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCCCNc3ccc4c(=O)c(C(=O)O)cn(C5CC5)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5433,ML00001312,CHEMBL1774296,,C=CCN1C[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5434,ML00004825,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](N)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)OCC2c3ccccc3-c3ccccc32)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5435,ML00009785,,,CC[C@H](C)[C@@H]1OC(=O)C(C)(C)[C@@H](O)[C@@H](Cc2ccccc2)OC(=O)[C@H](C(C)C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@H](C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5436,ML00002598,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CNCCOC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5437,ML00002028,CHEMBL312972,,CCOC(=O)N1CCN(C(=O)CNC(=O)[C@@H]2CCCCNC(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N2)CC1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5438,ML00005315,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN(C)CCNc3ccc4c(=O)c(C(=O)O)cn(C5CC5)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5439,ML00006443,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5440,ML00005312,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccccc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5441,ML00004694,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN3CCN(c4ccc([N+](=O)[O-])cc4)CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5442,ML00004551,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccccc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccc(OC)cc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5443,ML00004797,,,CCCCNC(=O)O[C@@H]1[C@@H](C)N(C)C[C@H](C)C[C@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccc(OC)cc3)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5444,ML00003096,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN2/C(=N\C(C)C)O[C@H]([C@H]2C)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5445,ML00001635,CHEMBL1813071,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5446,ML00003754,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2ccc(F)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5447,ML00005798,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4ccccc4OC)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5448,ML00006455,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5449,ML00001726,CHEMBL3650142,,CC(C)[C@H]1NC(=O)C[C@@H](/C=C/CCS)OC(=O)C[C@H](O)[C@@H](C(C)C)NC(=O)[C@@H](C)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5450,ML00002748,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4ccc(Cl)c(Cl)c4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5451,ML00004395,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](NC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)OCC2c3ccccc3-c3ccccc32)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5452,ML00003638,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5453,ML00002689,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC[C@H](O)CNCCNc2ccc3ncccc3c2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5454,ML00002506,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]3[C@H](OC(C)=O)[C@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5455,ML00003408,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4cnccn4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5456,ML00005287,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4C(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5457,ML00001271,CHEMBL4060181,,C=C1/C=C/C(=O)N(C)CC(=O)N[C@@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5458,ML00006147,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5459,ML00008874,,,CC[C@H](C)[C@@H]1OC(=O)C(C)(C)[C@@H](O)[C@@H](Cc2ccccc2)OC(=O)[C@H](C(C)C)OC(=O)[C@@H](NC(=O)c2cccc(N)c2O)[C@H](C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5460,ML00003983,,,CC(=O)OC[C@]12[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]3[C@@H](OC(C)=O)[C@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@H](C)C(=O)O[C@H]([C@@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5461,ML00000946,CHEMBL2159136,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2O/C(=N/c2ccc(OC)cc2)N3C)[C@](C)(OC)C[C@@H](C)C(=O)N[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5462,ML00003449,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCc2ccccn2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5463,ML00006527,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc(F)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5464,ML00009765,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(=O)C(C)(O)CCc4ncccc4C(=O)OC[C@@]4(C)O[C@@]1([C@H]3C)[C@@H](OC(C)=O)[C@@H]4C(=O)[C@@H]2OC(C)=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5465,ML00001631,CHEMBL2029592,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5466,ML00005414,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3cc([N+](=O)[O-])cc([N+](=O)[O-])c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccc(OC)cc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5467,ML00000789,CHEMBL2041383,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OCCCNC(=O)CNc2ccnc3cc(Cl)ccc23)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5468,ML00006712,,,C[C@@H]1/C=C\[C@H](O)/C=C(/Cl)CCOC(=O)C2=CC[C@@H]3CCC[C@@]4(CCC[C@@H]14)N3C2,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5469,ML00002576,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCCc2ccccc2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5470,ML00002685,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCCCC2CNc3ccccc3C2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5471,ML00000381,CHEMBL1796688,SPIRUCHOSTATIN A,C=C(C)[C@H]1NC(=O)[C@H]2CSSCC/C=C/[C@H](CC(=O)N[C@H](C)C(=O)N2)OC(=O)C[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5472,ML00003450,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCc2cccnc2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5473,ML00006507,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(C)(OC(=O)c1ccoc1)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5474,ML00002958,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@](O)(CN3CCCC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)C1(C)C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5475,ML00005795,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCN2CCN(C(=O)c3ccco3)CC2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5476,ML00009580,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C(=O)Nc2ccccc2C(F)(F)F)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5477,ML00005971,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5478,ML00001640,CHEMBL2029598,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2cccnc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5479,ML00004172,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2OC(=O)N3CC)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5480,ML00006267,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CN2CCN(c3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)CC2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5481,ML00002086,CHEMBL3971304,,CN1Cc2cc(ccc2S(=O)(=O)C2CC2)NC(=O)OCCc2cccc(c2)[C@@H](Nc2ccc3c(N)nccc3c2)C1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5482,ML00004621,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccc(Cl)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccccc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5483,ML00001344,CHEMBL4079630,,C#CCCCCCCCCC(=O)OCC[C@@H]1C(=O)NC(=C)/C=C/C(=O)N[C@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@H]1[C@H](C)CCCCCC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5484,ML00005648,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4ccnc5ccccc45)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5485,ML00006099,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN[C@@H](C)c3ccc([N+](=O)[O-])cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5486,ML00005295,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCNCCOCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5487,ML00005219,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCOCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5488,ML00000931,CHEMBL3823909,,COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc3oc(-c4ccc(-c5c[nH]c([C@@H]6C[C@@H]7CN6C(=O)[C@H](C(C)C)NC(=O)OCCCCCCO7)n5)cc4)cc3c2)[nH]1)C(C)C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5489,ML00003627,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@H]4C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5490,ML00000659,CHEMBL1553161,,CO[C@H]1COC(=O)[C@@H](C)COC(=O)[C@@H](COCc2ccccc2)NC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5491,ML00003850,,,CCCN1C[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C(N)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5492,ML00006546,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCNc2cc3c(=O)c(C(=O)O)cn(C4CC4)c3cc2Cl)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5493,ML00000430,CHEMBL1946562,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(=O)CNc3ccnc4cc(Cl)ccc34)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5494,ML00009488,,,CC[C@@H]1CCC(=O)O[C@H]2[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]3(OC(C)=O)[C@H](OC(C)=O)C(=O)[C@@H]4[C@@H](OC(C)=O)[C@]3(O[C@@]4(C)COC(=O)c3ccccc31)[C@@]2(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5495,ML00002212,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]3[C@@H](OC(C)=O)[C@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@H](C)C(=O)O[C@H]([C@@H](OC(=O)c1cccnc1)[C@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5496,ML00006103,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ccc(C(=O)N(C)c5ccncc5)cc4F)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5497,ML00001758,CHEMBL88351,,Cc1csc(NC(=O)CNC(=O)[C@@H]2CCCCN(C)C(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N2)n1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5498,ML00000469,CHEMBL4071537,,C=C1/C=C/C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5499,ML00006593,,,CC[C@H](C)[C@H]1NC(=O)[C@@H]2CSSCC/C=C\[C@H](CC(=O)N[C@H](CC[S@@](C)=O)C(=O)N2)OC(=O)C[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5500,ML00005231,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCOc3cc4c(=O)c(C(=O)OC(C)C)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5501,ML00006575,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN(C)[C@@H](CN(c3cccnc3)c3cccnc3)COC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5502,ML00005304,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN(C)CCNc3cc4c(=O)c(C(=O)OC)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5503,ML00006564,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccccc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5504,ML00004550,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3ccc4c(c3)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5505,ML00011012,,,CC[C@H]1OC(=O)C[C@@H](O)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H]2C[C@@H](C)c3cc(ncc32)[C@@]2(C)O[C@H]2[C@@H]1C,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5506,ML00001454,CHEMBL3601453,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCCc2cn(CCc3c[nH]c4ccccc34)nn2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5507,ML00004727,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCNC(=O)c3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5508,ML00002562,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(c3ccco3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5509,ML00003177,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5510,ML00002754,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5511,ML00005796,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5512,ML00002026,CHEMBL2115226,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)N[C@@H]2c3ccccc3C[C@@H]2O)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5513,ML00005248,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCOc3ccc4c(c3)c(=O)c(C(=O)OCC(C)=O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5514,ML00010729,,,CCNC(=O)N1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5515,ML00005571,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4cnc5ccccc5c4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5516,ML00003178,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(OC(=O)c1ccccc1)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5517,ML00002060,CHEMBL89406,,CCOC(=O)N1CCC(NC(=O)[C@@H]2CCCCNC(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N2)CC1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5518,ML00009743,,,CC[C@H]1OC(=O)[C@H](C)C2OC3(CCNCC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5519,ML00004438,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3cccc(-c4cn(CCCCCCC(=O)NO)nn4)c3)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5520,ML00005655,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4ccc5ccccc5n4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5521,ML00004522,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3ccc4c(c3)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5522,ML00003180,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5523,ML00004521,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCCCNc3ccc4c(=O)c(C(=O)O)cn(CC)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5524,ML00005656,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2cccc(C)c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccccc2Cl)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5525,ML00004459,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN[C@@H](C)C(=O)Nc3ccc4ccccc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5526,ML00001524,CHEMBL2315000,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@@]2(O)[C@H](C)C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@@]32C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5527,ML00001093,CHEMBL313199,,CNC(=O)[C@@H]1CCCCNC(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5528,ML00001480,CHEMBL1813070,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(OC(C)=O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5529,ML00005579,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCNC(C)Cc2ccc(OC)cc2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5530,ML00002599,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CN(C)CCO)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5531,ML00008127,,,CCC[C@H]1C/C=C\C/C=C\CCCC(=O)OCCN1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5532,ML00006591,,,CC[C@H](C)[C@H]1NC(=O)[C@@H]2CSSCC/C=C\[C@H](CC(=O)N[C@H](CCSC)C(=O)N2)OC(=O)C[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5533,ML00003181,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5534,ML00002589,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](OC)[C@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5535,ML00004776,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)CCN(CCCCc4ccccc4)C[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(C)=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5536,ML00002055,CHEMBL330723,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)Nc2ccccn2)CCCCN(C)C(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5537,ML00004398,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccc(F)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2Cl)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5538,ML00000436,CHEMBL1682456,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(C#N)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5539,ML00005460,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN3CCN(CCCc4ccc5c(c4)c(=O)c(C(=O)O)cn5CC)CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5540,ML00009682,,,CC[C@@H](C)[C@@H]1OC(=O)C(C)(C)[C@@H](O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](C(C)C)OC(=O)[C@H](NC(=O)c2cccc(NC=O)c2O)[C@H](C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5541,ML00001702,CHEMBL316061,,CNC(=O)CNC(=O)[C@@H]1CCCCN(C)C(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5542,ML00001145,CHEMBL3775624,,C=C1/C=C/C(=O)N(C)CC(=O)N[C@@H]([C@H](O)C(=O)OC)C(=O)O[C@@H]([C@H](C)CCCCCCCCCCCCC(C)C)[C@H](C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5543,ML00001317,CHEMBL1774298,,CCNC(=O)N1C[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5544,ML00010660,,,CC(C)C[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)OC(=O)[C@H](Cc2ccccc2)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5545,ML00001663,CHEMBL2029764,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@H](C)c2ccc3cc(OC)ccc3c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5546,ML00000349,CHEMBL1774452,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(Cc2ccc(F)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5547,ML00005392,,,CCC(=O)CNC(=O)COC(=O)c1cn(C2CC2)c2ccc(NCCOCCC(=O)O[C@H]3[C@H](C)O[C@@H](O[C@H]4[C@H](C)[C@@H](O[C@@H]5O[C@H](C)C[C@H](N(C)C)[C@H]5O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]4C)C[C@@]3(C)OC)cc2c1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5548,ML00005968,,,CCCCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5549,ML00006292,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccc([N+](=O)[O-])cc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5550,ML00005421,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@@]2(O)CC[C@H]3[C@@H]4CCC5=CC(=O)CC[C@]5(C)[C@H]4[C@@H](O)C[C@@]32C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5551,ML00003208,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5552,ML00004564,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](n3cccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)OCC2c3ccccc3-c3ccccc32)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5553,ML00005988,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(NC(=O)CCCCCCC(=O)NO)cc3)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5554,ML00000879,CHEMBL2029596,,CCOc1ccc2ccccc2c1CNCCCN1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5555,ML00000477,CHEMBL1774304,,C=CO[C@]1(C)C[C@@H](C)CN(Cc2ccccc2)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5556,ML00003325,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@](O)(CN)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5557,ML00003461,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCc2ccc(F)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5558,ML00000566,CHEMBL1682704,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2sc3c(c2C(=O)OC)CCCC3)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5559,ML00009351,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CCC(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5560,ML00003104,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5561,ML00002304,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CN2CCN(c3ccc(F)cc3)CC2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5562,ML00006165,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN(C)C[C@H](COc3ccc(-c4ccccn4)cc3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5563,ML00000193,CHEMBL504859,ZYGOSPORAMIDE,CC(C)C[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)OC(=O)[C@H](Cc2ccccc2)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5564,ML00002032,CHEMBL88651,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCCc2c[nH]c3ccc(F)cc23)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5565,ML00006253,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCNC(=O)c3ccc(F)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5566,ML00001310,CHEMBL2159132,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2O/C(=N\C(C)C)N3C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5567,ML00002056,CHEMBL89838,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCCC(C(=O)O)C2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5568,ML00005986,,,CCN(C[C@H]1COC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN1C)c1cccnc1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5569,ML00002509,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5570,ML00006244,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN(C)C[C@H](COc3ccc(-c4ccccc4)cc3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5571,ML00000221,CHEMBL555663,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccc3ccccc3c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5572,ML00003200,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3ccccc3)[C@H]3OC(=O)C(C)(O)CCc4ccncc4C(=O)OC[C@@]4(C)O[C@@]1([C@H]3C)[C@@H](OC(C)=O)[C@@H]4[C@@H](OC(C)=O)[C@@H]2OC(C)=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5573,ML00000793,CHEMBL2041573,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OCCCNCc2cnc3ccccc3c2)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5574,ML00002089,CHEMBL4064863,,C=C1/C=C/C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)O[C@@H]([C@@H](C)CCC)[C@@H](CCOCc2ccc(OC)cc2)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5575,ML00006829,,,C/C1=C/CC/C(C(C)C)=C/C(=O)OC(C)CC/C(C)=C2\OC(=O)C3C2C1OC3(C)O,standard_macrolactone,15.0,,,success,,4.0,"[3, 6, 10, 14]",ring_size_15/standard/numbered/ML00006829_numbered.png,2026-03-19 06:57:35.221825
5576,ML00003346,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@]3(CO3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5577,ML00000863,CHEMBL361977,,CC(C)C[C@H](NC(=O)[C@@H]1CC(=O)NCCCCCOC(=O)N[C@@H](C(C)C)C(=O)N1)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5578,ML00008121,,,CO[C@H]1COC(=O)[C@H](C)NC(=O)[C@@H](C)COC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5579,ML00008945,,,CCCCCCCCCCCCC[C@H]1OC(=O)[C@H](COC(C)=O)NC(=O)[C@@H]([C@H](C)O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5580,ML00005428,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@@]2(O)CC[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@@]32C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5581,ML00001498,CHEMBL2314998,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@@]2(O)[C@H](C)C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@@]32C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5582,ML00002465,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN2/C(=N\c3cccc4ccccc34)O[C@H]([C@H]2C)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5583,ML00009703,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5584,ML00000580,CHEMBL1682596,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)NC(C)(C)CC(C)(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5585,ML00009473,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)N[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5586,ML00001579,CHEMBL1813068,MEKONGENSINE,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(OC(C)=O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5587,ML00005569,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4ccc5ccccc5n4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5588,ML00000519,CHEMBL1682573,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2cc(F)ccc2C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5589,ML00002510,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5590,ML00001672,CHEMBL313519,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NC[C@H]2CCCO2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5591,ML00000433,CHEMBL1682604,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCc2ccco2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5592,ML00003864,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(Cn3ccnn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5593,ML00005264,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNCCCNCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5594,ML00000332,CHEMBL553183,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5595,ML00002337,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4nc5ccccc5[nH]4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5596,ML00006248,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCNC(=O)c3cc([N+](=O)[O-])cc([N+](=O)[O-])c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5597,ML00000546,CHEMBL1682715,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccc(CC#N)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5598,ML00006284,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN[C@@H](C)c3ccc([N+](=O)[O-])cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5599,ML00006023,,,CC(=O)OCC12C(OC(C)=O)C(OC(C)=O)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1CCC(C)(OC(=O)c1ccccc1)C(=O)OC(C(OC(C)=O)C2OC(C)=O)C4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5600,ML00004577,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccc(O)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2Cl)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5601,ML00005437,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCNc3cc4c(=O)c(C(=O)OCOCCOC)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5602,ML00006194,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(OC(C)=O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5603,ML00006305,,,CCCCCCCCCCCC(=O)O[C@@H]1[C@H]2[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@]3(COC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]4OC(=O)C(C)CCc5ccncc5C(=O)OC[C@]2(C)O[C@]13[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5604,ML00010639,,,CC[C@H]1/C=C\[C@H](O)[C@H](C=C(C)C)OC(=O)[C@@]2(C)C=CC(=O)Nc3c2c(C)c2c(c(O)c(C)cc2c3C)C(=O)CC1,standard_macrolactone,15.0,,,success,,6.0,"[3, 4, 7, 10, 13, 15]",ring_size_15/standard/numbered/ML00010639_numbered.png,2026-03-19 06:57:35.489795
5605,ML00003188,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(C)(OC(C)=O)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5606,ML00000571,CHEMBL1682711,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2c(C)noc2-c2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5607,ML00006531,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccc(F)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5608,ML00006097,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3ccc(-c4cn(CC(=O)NO)nn4)cc3)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5609,ML00006514,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5610,ML00002619,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4cccnc4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5611,ML00003046,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@](O)(CNC(C)(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5612,ML00004606,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccccc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccc(O)cc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5613,ML00001685,CHEMBL89137,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NC[C@@H]2CCCO2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5614,ML00004720,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=O)Nc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5615,ML00002053,CHEMBL330513,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCCc2ccccc2O)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5616,ML00006192,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(OC(=O)c1ccccc1)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5617,ML00006250,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCNC(=O)c3ccc(Br)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5618,ML00001615,CHEMBL2029741,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2ccncc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5619,ML00006045,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCO[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5620,ML00010378,,,CON1O/C=C\C=C(N)/C=C\C[C@H]2CC(=O)O[C@H](CO)/C=C\[C@@H](OC(C)=O)/C(C)=C\Cc3cccc(c3C(=O)O2)O1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5621,ML00004803,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=O)NCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5622,ML00003048,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(c3cccnc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5623,ML00009702,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5624,ML00006945,,,C[C@H]1CC/C=C/N(C)C(=O)CCC[C@@H](C)C[C@H](C(C)(C)C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5625,ML00004394,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc(Cl)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5626,ML00004723,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN[C@@H](C)C(=O)Nc3ccc([N+](=O)[O-])cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5627,ML00009564,,,CCCCCNC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5628,ML00000964,CHEMBL2029352,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCC(=O)NCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5629,ML00005782,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4nc(Cl)nc(-c5ccccc5)n4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5630,ML00001456,CHEMBL3601570,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCCc2cn(CCN3CCc4ccccc43)nn2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5631,ML00002082,CHEMBL313082,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCN(c3ccccc3)CC2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5632,ML00009643,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN2/C(=N\Cc3ccccc3)O[C@H]([C@H]2C)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5633,ML00003189,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]3[C@@H](OC(C)=O)[C@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(OC(=O)c1ccoc1)C(=O)O[C@H]([C@@H](OC(C)=O)[C@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5634,ML00001452,CHEMBL3601568,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCCc2cn(CCn3ccc4cc([N+](=O)[O-])ccc43)nn2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5635,ML00002058,CHEMBL316158,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CC(C)OC(C)C2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5636,ML00001733,CHEMBL88133,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)N[C@H](C)C(=O)N2CCOCC2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5637,ML00007613,,,CON1O/C=C\C=C(N)/C=C\C[C@H]2CC(=O)O[C@H](CO)/C=C\[C@@H](O)/C(C)=C\Cc3cccc(c3C(=O)O2)O1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5638,ML00000573,CHEMBL1682723,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(N3CCOCC3)nc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5639,ML00003012,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5640,ML00008946,,,CCCCCCCCCCCCC[C@@H]1OC(=O)[C@H](COC(C)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)[C@@H](O)[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5641,ML00003943,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(C)(OC(C)=O)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5642,ML00008938,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN(C(=O)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5643,ML00001375,CHEMBL4080353,,C=C1/C=C/C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCOC(=O)[Si](C(C)C)(C(C)C)C(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5644,ML00003086,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CN3CCOCC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5645,ML00002280,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4ccccc4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5646,ML00010632,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)C3OC3c3ccccc3)OC(=O)[C@H](CC(C)C)OCCNC2=O)cc1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5647,ML00007318,,,CO[C@@]1(C)[C@H]2Cc3cc(ccc3O)C(=O)O[C@H](C(C)(C)Br)CC[C@](C)(O)[C@H](Br)CC[C@]2(C)[C@H]2C[C@H]21,standard_macrolactone,15.0,,,success,,5.0,"[3, 6, 6, 7, 10]",ring_size_15/standard/numbered/ML00007318_numbered.png,2026-03-19 06:57:35.829544
5648,ML00001740,CHEMBL430636,,CNC(=O)[C@@H](CCCCN)NC(=O)[C@@H]1CCCCNC(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5649,ML00004278,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2Cl)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5650,ML00000497,CHEMBL1682606,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccc3c(c2)OCO3)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5651,ML00004220,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5652,ML00007986,,,O=C1CCC/C=C\CCCCCCCCO1,standard_macrolactone,15.0,,,success,,0.0,[],ring_size_15/standard/numbered/ML00007986_numbered.png,2026-03-19 06:57:35.890882
5653,ML00001647,CHEMBL1774294,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C(=O)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5654,ML00007620,,,CO/N=C\C=C/C(=O)N/C=C/C[C@H]1CC(=O)O[C@@H](C)/C=C\[C@@H](O)/C(C)=C\Cc2cccc(O)c2C(=O)O1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5655,ML00000792,CHEMBL2041572,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OCCCNCc2ccnc3ccccc23)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5656,ML00000511,CHEMBL1682462,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(/N=N/c3ccccc3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5657,ML00005538,,,CCCCCCNC(=O)O[C@@H]1[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](OC(=O)Nc2ccc(OC)cc2)[C@@H](C)C(=O)O[C@H](CC)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5658,ML00005306,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNC(=O)CCNCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5659,ML00004708,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4cccc(C)c4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5660,ML00006220,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCNCCNc2cc3c(=O)c(C(=O)O)cn(C4CC4)c3cc2Cl)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5661,ML00003931,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCc2ccccc2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5662,ML00003240,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5663,ML00009693,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(C)(O)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5664,ML00006021,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(OC(=O)c1ccccc1)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5665,ML00000147,CHEMBL506834,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5666,ML00006396,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(c3cc4ccccc4n3C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5667,ML00001288,CHEMBL2159130,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2O/C(=N\CCCSC)N3C)[C@](C)(OC)C[C@@H](C)C(=O)N[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5668,ML00001343,CHEMBL362078,,CC(C)C[C@H](NC(=O)[C@@H]1CC(=O)NC/C=C/CCOC(=O)N[C@@H](C(C)C)C(=O)N1)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5669,ML00003202,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5670,ML00003182,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5671,ML00000500,CHEMBL1682577,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)N[C@H]2CCCC[C@H]2OCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5672,ML00001485,CHEMBL2029749,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2ccnc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5673,ML00003914,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCCc2cccnc2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5674,ML00002930,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)CN(C)C[C@@H](COCc3ccccc3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5675,ML00006581,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccco3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C2OC(=O)OC12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5676,ML00003010,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5677,ML00010659,,,CC(C)C[C@@H]1OC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5678,ML00006283,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN[C@H](C)c3ccc([N+](=O)[O-])cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5679,ML00003635,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3[C@@H](OC(C)=O)[C@]14O[C@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5680,ML00000550,CHEMBL1682728,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCCCN(CC)CC)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5681,ML00003332,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5682,ML00002601,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@](O)(CNC3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5683,ML00005510,,,CC(=O)OC[C@]12[C@H](OC(=O)c3ccccc3)[C@H](OC(=O)c3ccccc3)[C@H]3OC(=O)C(C)(O)CCc4ncccc4C(=O)OC[C@@]4(C)O[C@@]1([C@H]3C)[C@@H](OC(C)=O)[C@@H]4C(=O)[C@@H]2OC(C)=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5684,ML00000656,CHEMBL3218562,,CCCC[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)N[C@H](C(C)C)[C@@H](O)CC(=O)O2,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5685,ML00006480,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5686,ML00006043,,,CCCCCCCC(=O)NCCCN1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5687,ML00001952,CHEMBL4085556,,C#CCCCC(=O)OCC[C@@H]1C(=O)NC(=C)/C=C/C(=O)N[C@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@H]1[C@H](C)CCCCCC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5688,ML00000447,CHEMBL1682445,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc([N+](=O)[O-])cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5689,ML00003363,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5690,ML00003205,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3[C@@H](OC(C)=O)[C@]14O[C@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5691,ML00000547,CHEMBL1682601,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2cc(F)cc3c2OCOC3)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5692,ML00002025,CHEMBL2114232,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)N[C@H]2c3ccccc3C[C@H]2O)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5693,ML00003744,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5694,ML00002452,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNc2ccc3ncccc3c2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5695,ML00003554,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@H](CO)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@H]4CO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5696,ML00004799,,,CCCCNC(=O)O[C@@H]1[C@@H](C)N(C)C[C@H](C)C[C@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccc(O)cc3)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5697,ML00005251,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3cc([N+](=O)[O-])cc([N+](=O)[O-])c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2Cl)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5698,ML00002122,CHEMBL90727,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCN(c3ccccn3)CC2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5699,ML00003622,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)N[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5700,ML00000570,CHEMBL2041393,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OCCCNCc2cnc3ccccc3c2)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5701,ML00001785,CHEMBL89947,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCc2ccccc2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5702,ML00003014,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5703,ML00006845,,,C=C1CC/C=C\C(=O)[C@H](C)/C=C\[C@@H](O)[C@@H]([C@H](C)/C=C/CCC)OC(=O)C[C@H]1C,standard_macrolactone,15.0,,,success,,6.0,"[3, 4, 7, 8, 13, 14]",ring_size_15/standard/numbered/ML00006845_numbered.png,2026-03-19 06:57:36.381035
5704,ML00003927,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ccc([N+](=O)[O-])cn4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5705,ML00006490,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5706,ML00005461,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCC(=O)NCCOCCOCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5707,ML00006061,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(Cc2ccc(-c3cn(CC(=O)NO)nn3)cc2)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5708,ML00003667,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2OC(=O)N3C)[C@](C)(OC)C[C@@H](C)C(=O)N[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5709,ML00004846,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNCCNC(=O)CSc3cnc4ccccc4n3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5710,ML00006743,,,O=C1CCc2ccc(OCc3ccccc3)c(c2)Oc2ccc(cc2)/C=C\CO1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5711,ML00004545,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3cc4c(=O)c(C(=O)OC)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5712,ML00005310,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCNCCOCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5713,ML00003833,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4cc(OC)nc(OC)n4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5714,ML00001357,CHEMBL1774302,,C=CO[C@]1(C)C[C@@H](C)CN(CCC)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5715,ML00003184,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CC[C@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5716,ML00004883,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccccc3OC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5717,ML00000438,CHEMBL1682454,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2cccc(C(F)(F)F)c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5718,ML00000252,CHEMBL3126833,,CSCC[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)N[C@H](C(C)C)[C@@H](O)CC(=O)O2,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5719,ML00009783,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@@H]3CCCN3C2=O)cc1Cl,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5720,ML00000502,CHEMBL2041385,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OCCCNC(=O)CCCNc2ccnc3cc(Cl)ccc23)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5721,ML00004615,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccccc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccccc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5722,ML00004807,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3ccc(-c4cn(CCCCCC(=O)NO)nn4)cc3)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5723,ML00005285,,,CCN(CCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)[C@H](N)[C@H](C)CN(C)C[C@H](COCc3ccccc3)OC(=O)[C@@H]2C)C[C@@]1(C)OC)[C@@H](C)c1ccccc1OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5724,ML00009112,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN2/C(=N\C(C)C)O[C@H]([C@H]2C)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5725,ML00005469,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5726,ML00000556,CHEMBL1682580,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2cccc(SC)c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5727,ML00001342,CHEMBL4093628,,C=C1/C=C/C(=O)N[C@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCOC(=O)C23CC4CC(CC(C4)C2)C3)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5728,ML00009601,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN(C(=O)Nc2ccc(Cl)cc2Cl)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5729,ML00003446,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ccc([N+](=O)[O-])c(N)n4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5730,ML00001619,CHEMBL4063988,,C=C1/C=C/C(=O)N[C@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCOC(=O)CC(c2ccccc2)(c2ccccc2)c2ccccc2)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5731,ML00002981,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@H]4C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5732,ML00010067,,,CC(=O)O[C@@H]1/C(C)=C\[C@H](C)[C@@H](OC(C)=O)[C@@H](C)[C@H](C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)/C=C\[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5733,ML00009568,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]3NC(=O)O[C@H]32)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5734,ML00003941,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCc2ccc(OC)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5735,ML00007323,,,CC(=O)O[C@@H]1[C@@H](C)/C=C(/C)[C@@H](O)[C@H](C)/C=C\C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)O[C@@H](C)[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5736,ML00006238,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)NCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5737,ML00003961,,,CC(=O)OC[C@]12[C@H](OC(=O)c3ccccc3)[C@H](OC(C)=O)[C@H]3OC(=O)C(C)(O)CCc4ncccc4C(=O)OC[C@@]4(C)O[C@@]1([C@H]3C)[C@@H](OC(C)=O)[C@@H]4C(=O)[C@@H]2OC(C)=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5738,ML00002234,,,C=C1Oc2cc(OC)cc(C(=O)O[C@@H]3OC(=O)C[C@H](N)c4cc(O)c(c(Cl)c4)O[C@@H]4c5ccc3cc5C3=CC=C[C@@]34O[C@@H]3OC(C)(C)[C@@H](N(C)C)[C@@H](O)[C@H]3O)c2NC1=O,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5739,ML00001738,CHEMBL88445,,CNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H]1CCCCNC(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5740,ML00001539,CHEMBL3601571,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(Cc2ccc(-c3cn(CCc4c[nH]c5ccccc45)nn3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5741,ML00005332,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCNc3ccc4c(c3)c(=O)c(C(=O)OC(C)C)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5742,ML00007559,,,C/C1=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)/C=C\[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5743,ML00005582,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCCNC(=O)CCCNc3ccnc4ccccc34)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5744,ML00004002,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@H]([C@H](O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5745,ML00006843,,,C=C1/C=C\C(=O)N(C)CC(=O)NC(C(O)C(N)=O)C(=O)OC(C(C)CCCCCC)C(C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5746,ML00009171,,,CC(C)CC1NC(=O)C(Cc2ccccc2)NC(=O)C(CC(C)C)N(C)C(=O)C(C(C)C)NC(=O)C(CC(C)C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5747,ML00003407,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ncccc4[N+](=O)[O-])CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5748,ML00001534,CHEMBL3601572,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(Cc2ccc(-c3cn(CCc4c[nH]c5ccc(Cl)cc45)nn3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5749,ML00009685,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5750,ML00001475,CHEMBL2029587,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNc2ccnc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5751,ML00006098,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN[C@H](C)c3ccc([N+](=O)[O-])cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5752,ML00005325,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4c(Cl)cccc4Cl)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(OC)cc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5753,ML00000559,CHEMBL1682591,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(C)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5754,ML00000181,CHEMBL1774625,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCNC(=O)Nc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5755,ML00000563,CHEMBL1682602,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccc(C)cc2C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5756,ML00001108,CHEMBL3775355,,C=C1/C=C/C(=O)N(C)CC(=O)N[C@@H]([C@H](O)C(=O)OC)C(=O)O[C@@H]([C@@H](C)CCCCCCCCCCCC(C)C)[C@H](C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5757,ML00004612,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN3CCN(c4cc5c(cc4F)c(=O)ccn5C4CC4)CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5758,ML00004808,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3cccc(-c4cn(CCCCCC(=O)NO)nn4)c3)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5759,ML00006442,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5760,ML00000509,CHEMBL1682582,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccc(OC)c(OC3CCCC3)c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5761,ML00002896,,,CC[C@H]1CCC(=O)O[C@H]2[C@H](OC(C)=O)[C@H](OC(=O)c3ccccc3)[C@@]3(COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]4[C@@H](OC(C)=O)[C@]3(O[C@@]4(C)COC(=O)c3cccnc31)[C@@]2(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5762,ML00003832,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ccc(C)nn4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5763,ML00010267,,,CCCCCCCCCC1OC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(C(C)C)NC(=O)C(C)C(O)C1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5764,ML00006251,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCNC(=O)c3ccc(Cl)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5765,ML00002928,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)CN(C)[C@@H](COCc3ccccc3)COC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5766,ML00000510,CHEMBL1682594,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(N(C)C)c3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5767,ML00007278,,,C=C(C)[C@@H]1CC[C@](C)(O)[C@H](Br)CC[C@]2(C)[C@@H](Br)CCC(=C)[C@H]2Cc2cc(ccc2O)C(=O)O1,standard_macrolactone,15.0,,,success,,5.0,"[3, 6, 6, 7, 10]",ring_size_15/standard/numbered/ML00007278_numbered.png,2026-03-19 06:57:36.917139
5768,ML00004888,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNC(=O)CNC(=O)CSc3cnc4ccccc4n3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5769,ML00000882,CHEMBL2314756,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@@]2(O)[C@H](C)C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@@]32C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5770,ML00003406,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ccc([N+](=O)[O-])cn4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5771,ML00001929,CHEMBL164673,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)NC2=O)cc1Cl,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5772,ML00001487,CHEMBL2029758,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)CCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5773,ML00004611,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCNCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5774,ML00001432,CHEMBL2029742,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2ccncc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5775,ML00005388,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCNc3ccc4c(c3)c(=O)c(C(=O)OCCN3CCCCC3)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5776,ML00004383,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3ccc4c(=O)c(C(=O)O)cn(CC)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5777,ML00003861,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CNCC(F)(F)F)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5778,ML00009172,,,CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5779,ML00000625,CHEMBL1257967,,CC1=C2Cc3cc(ccc3O)C(=O)O[C@H](C(C)(C)Br)CC[C@](C)(O)[C@H](Br)CC[C@]2(C)[C@@H](Br)CC1,standard_macrolactone,15.0,,,success,,5.0,"[3, 6, 6, 7, 10]",ring_size_15/standard/numbered/ML00000625_numbered.png,2026-03-19 06:57:37.060490
5780,ML00004884,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccc(C)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5781,ML00002988,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccc(Br)cc4)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CCC(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5782,ML00002580,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CN(C)CCc2ccc([N+](=O)[O-])cc2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5783,ML00003099,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(c3nccn3C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5784,ML00006582,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3cccs3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C2OC(=O)OC12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5785,ML00007821,,,O=C1CCc2ccc(O)c(c2)Oc2ccc(cc2)/C=C\CO1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5786,ML00000047,CHEMBL1836145,THAILANDEPSIN B,CCCC[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)N[C@H]([C@@H](C)CC)[C@@H](O)CC(=O)O2,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5787,ML00004568,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccc(O)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2Cl)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5788,ML00002316,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4ccc(Cl)cc4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5789,ML00001479,CHEMBL2029757,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)CCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5790,ML00000064,CHEMBL1836142,THAILANDEPSIN A,CC[C@H](C)[C@H]1NC(=O)[C@H]2CSSCC/C=C/[C@H](CC(=O)N[C@H](CCSC)C(=O)N2)OC(=O)C[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5791,ML00000880,CHEMBL2314757,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@@]2(O)[C@H](C)C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@@]32C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5792,ML00002824,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN2/C(=N\c3ccc(-c4ccccc4)cc3OC)O[C@H]([C@H]2C)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5793,ML00010444,,,CON1O/C=C\C=C(N)/C=C\C[C@H]2CC(=O)O[C@H](COC(C)=O)/C=C\[C@@H](O)/C(C)=C\Cc3cccc(c3C(=O)O2)O1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5794,ML00000234,CHEMBL1774634,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCNC(=S)NCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5795,ML00002738,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=S)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5796,ML00000963,CHEMBL2029593,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5797,ML00000507,CHEMBL563766,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=O)Nc2ccc3ccccc3c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5798,ML00007524,,,C/C=C/C/C=C/[C@H](C)C[C@H](O)[C@@H]1C[C@@H]2O[C@H]2/C=C\[C@H](O)[C@@H](O)/C=C\C[C@H](C)CC(=O)O1,standard_macrolactone,15.0,,,success,,4.0,"[3, 9, 10, 14]",ring_size_15/standard/numbered/ML00007524_numbered.png,2026-03-19 06:57:37.251075
5799,ML00006218,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccc(Cl)cc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5800,ML00010212,,,C=C1NC(=O)C(C(C)O)NC(=O)C(C(C)C)NC(=O)C(C)C(O)C(C)C(CCCCCCCCC)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5801,ML00009611,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN(C(=O)Nc2ccc(Cl)cc2Cl)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5802,ML00010640,,,CCC(C)C1OC(=O)C(C)(C)C(=O)C(Cc2ccccc2)OC(=O)C(C)OC(=O)C(NC(=O)c2ccccc2)C(C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5803,ML00005471,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccc(F)cc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5804,ML00009346,,,CC(C)[C@@H]1OC(=O)[C@@H](NC(=O)c2cccc(N)c2O)[C@H](C)OC(=O)[C@H](C(C)C)OC(=O)C(C)(C)[C@@H](O)[C@@H](Cc2ccccc2)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5805,ML00008687,,,COc1c(O)cc2cc1Oc1ccc(cc1)CCCOC(=O)CC2,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5806,ML00003017,,,CC(=O)OC[C@]12[C@@H](OC(C)=O)[C@@H](OC(=O)c3ccccc3)[C@@H]3OC(=O)[C@@H](C)CCc4ncccc4C(=O)OC[C@@]4(C)O[C@@]1([C@@H](OC(C)=O)[C@H]4[C@@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5807,ML00010534,,,CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)OC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(Br)cc2)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5808,ML00003355,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5809,ML00006107,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2O/C(=N/c2cccc4ccccc24)N3C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5810,ML00009118,,,C=CCO[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)N[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5811,ML00001739,CHEMBL91120,,CNC(=O)[C@H](NC(=O)[C@@H]1CCCCNC(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N1)C(C)(C)C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5812,ML00001462,CHEMBL3601456,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCCc2cn(CCc3cn(C)c4ccccc34)nn2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5813,ML00002101,CHEMBL2441613,,CC(=O)Oc1ccc2cc1CC1=C(C)CC[C@H](Br)[C@@]1(C)CC[C@@H](Br)[C@@](C)(O)CC[C@@H](C(C)(C)Br)OC2=O,standard_macrolactone,15.0,,,success,,5.0,"[3, 6, 6, 7, 10]",ring_size_15/standard/numbered/ML00002101_numbered.png,2026-03-19 06:57:37.410405
5814,ML00001476,CHEMBL2029587,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNc2ccnc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5815,ML00006286,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/N[C@H](C)Cc2ccc([N+](=O)[O-])cc2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5816,ML00003852,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CN(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5817,ML00004553,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCCCOC#Cc3ccc4c(c3)c(=O)c(C(=O)O)cn4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5818,ML00005972,,,CCCCCCNC[C@@]1(O)[C@H](C)O[C@@H](OC2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5819,ML00002034,CHEMBL89419,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)Nc2ccc(N3CCOCC3)cc2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5820,ML00002902,,,C=CCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]3OC(=O)O[C@]3(C)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5821,ML00003075,,,CCCCNC[C@]1(O)[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5822,ML00001727,CHEMBL91425,,CNC(=O)[C@@H](C)NC(=O)[C@@H]1CCCCNC(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5823,ML00005785,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCNC(C)C(=O)Nc2ccccc2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5824,ML00005819,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4ccnc5ccccc45)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5825,ML00006285,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN3CCN(C(=O)c4ccco4)CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5826,ML00003636,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5827,ML00000886,CHEMBL2029755,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCC(=O)N[C@H](C)c2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5828,ML00004006,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5829,ML00004595,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccc(O)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5830,ML00006242,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN(C)C[C@H](COc3ccccc3-c3ccccc3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5831,ML00004798,,,CCCCNC(=O)O[C@@H]1[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccc(O)cc3)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5832,ML00000411,CHEMBL1681796,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2cc(Cl)cc(Cl)c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5833,ML00001847,CHEMBL3358526,,C[C@H]1CC/C=C/N(C)C(=O)CCC[C@@H](C)C[C@@H](C(C)(C)C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5834,ML00003015,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5835,ML00000213,CHEMBL1774641,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCN(CCC(N)=O)C(=O)Nc2ccc3ccccc3c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5836,ML00000794,CHEMBL2029595,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5837,ML00006109,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN2/C(=N\c3cccc4ccccc34)O[C@H]([C@H]2C)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5838,ML00008419,,,COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OCCCCCC(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5839,ML00002718,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ccc(C(=O)O)c(C(F)(F)F)c4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5840,ML00006256,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccc(F)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C2OC(=O)OC12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5841,ML00003843,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5842,ML00000435,CHEMBL1682598,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccc(C#N)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5843,ML00008184,,,CCC[C@H]1CCCC/C=C\CCCC(=O)OCCN1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5844,ML00001227,CHEMBL1774290,,CCCN1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5845,ML00005243,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCNC(=O)c3ccc(OC)c(OC)c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5846,ML00004540,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCOCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5847,ML00004007,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]3[C@@H](O)[C@]14O[C@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5848,ML00008424,,,COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OCCCCC/C(S)=N/1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5849,ML00003204,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]3[C@@H](OC(C)=O)[C@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5850,ML00005360,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(C)c(C)c2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5851,ML00009454,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)CN(C)CCOC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5852,ML00002586,,,CCCC[C@@]1(O)[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5853,ML00001245,CHEMBL311220,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5854,ML00004555,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccc([N+](=O)[O-])cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccc(OC)cc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5855,ML00001684,CHEMBL314428,,Cc1csc(NC(=O)[C@@H]2CCCCN(C)C(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N2)n1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5856,ML00003190,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(OC(=O)c1ccoc1)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5857,ML00000026,CHEMBL91636,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCOCC2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5858,ML00000082,CHEMBL1836144,,CC[C@H](C)[C@H]1NC(=O)[C@@H](CS)NC(=O)[C@@H](CCSC)NC(=O)C[C@@H](/C=C/CCS)OC(=O)C[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5859,ML00001455,CHEMBL3601457,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCCc2cn(CCn3ccc4ccccc43)nn2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5860,ML00005322,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccc(Cl)cc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(OC)cc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5861,ML00008678,,,COc1ccc2cc1Oc1ccc(cc1)C1OC1COC(=O)CC2,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5862,ML00003367,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5863,ML00001687,CHEMBL330249,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N(C)C)CCCCN(C)C(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5864,ML00010629,,,CCC(C)C1OC(=O)C(C)(C)C(O)C(Cc2ccccc2)OC(=O)C(C)OC(=O)C(NC(=O)c2cccc(N)c2O)C(C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5865,ML00000868,CHEMBL2041384,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OCCCNC(=O)CNc2ccnc3ccccc23)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5866,ML00004587,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCNCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5867,ML00000216,CHEMBL446811,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5868,ML00005536,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNc2ncnc3[nH]cnc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5869,ML00004855,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5870,ML00008882,,,CCCCCCCC[C@@H]1COC(=O)[C@H](CO)NC(=O)[C@H](C(=O)c2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5871,ML00008684,,,COc1ccc2cc1Oc1ccc(cc1)CCC(=O)OCCC2,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5872,ML00003242,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5873,ML00004437,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)(CN(C)Cc3ccc(-c4cn(CCCC(=O)NO)nn4)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5874,ML00003642,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CCC(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5875,ML00003511,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N(C)c2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5876,ML00004646,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccc(Br)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5877,ML00003192,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(OC(=O)c1ccccc1)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5878,ML00004734,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNC(=O)CSc3cnc4ccccc4n3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5879,ML00001104,CHEMBL3775146,,COC(=O)[C@@H](O)[C@@H]1NC(=O)CN(C)C(=O)/C=C/[C@H](CO)NC(=O)[C@@H](C)[C@H]([C@H](C)CCCCCCCCCCCC(C)C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5880,ML00000214,CHEMBL1774638,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCN(CCC#N)C(=O)Nc2ccc3ccccc3c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5881,ML00001547,CHEMBL3601574,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(Cc2ccc(-c3cn(CCc4cn(C)c5ccccc45)nn3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5882,ML00002982,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]3[C@@H](OC(C)=O)[C@]14O[C@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@@H]4C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5883,ML00000331,CHEMBL1774627,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCNC(=O)NCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5884,ML00000463,CHEMBL1774624,,CCNC(=O)NCCN1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5885,ML00001629,CHEMBL1774450,,C=CO[C@]1(C)C[C@@H](C)CN(C(=O)NCc2ccccc2)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5886,ML00000350,CHEMBL3352927,,C=C1/C=C/C(=O)N(C)CC(=O)N[C@H]([C@@H](O)C(N)=O)C(=O)O[C@@H]([C@H](C)CCCCCCCCCCCCCC(C)C)[C@H](C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5887,ML00006262,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CN2CCN(c3ccc4c(c3)c(=O)c(C(=O)O)cn4C3CC3)CC2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5888,ML00000855,CHEMBL508998,ALATUSININE,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5889,ML00000488,CHEMBL1682701,,CCCCNC(=S)NCCCN1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5890,ML00004867,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCN2CCN(c3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)CC2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5891,ML00004365,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5892,ML00000417,CHEMBL1682597,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2c(F)cccc2F)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5893,ML00007162,,,CC(C)=CCC[C@@](C)(O)[C@@H]1CC/C(C)=C\CC/C(C)=C\Cc2cc(ccc2O)C(=O)O1,standard_macrolactone,15.0,,,success,,3.0,"[3, 6, 10]",ring_size_15/standard/numbered/ML00007162_numbered.png,2026-03-19 06:57:38.074703
5894,ML00004530,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccccc3OC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5895,ML00004183,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5896,ML00000318,CHEMBL114878,,O=C1NCCCC[C@@H](C(=O)NCC(=O)N2CCNCC2)NC(=O)[C@H](Cc2ccc(-c3cc(C(F)(F)F)cc(C(F)(F)F)c3)cc2)[C@@H](C(=O)NO)CCCO1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5897,ML00007763,,,O=C1CCCCCC=CCCOC(=O)c2c(O)c(Br)c(O)c(Br)c2C1,standard_macrolactone,15.0,,,success,,1.0,[12],ring_size_15/standard/numbered/ML00007763_numbered.png,2026-03-19 06:57:38.120268
5898,ML00002643,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2cccc(OC)c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5899,ML00005938,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(Cl)cc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5900,ML00004549,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccccc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5901,ML00004824,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@H](N)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)OCC2c3ccccc3-c3ccccc32)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5902,ML00005542,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4cccc(F)c4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5903,ML00002695,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC[C@@H](O)CNCCNc2ccc3ncccc3c2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5904,ML00005991,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN(C)[C@H](COCc3ccccc3)COC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5905,ML00003097,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2O/C(=N/C(C)C)N3C)[C@](C)(OC)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5906,ML00002305,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4cccc(OC)c4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5907,ML00005808,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCNCCCc2ccccc2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5908,ML00003957,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(OC(C)=O)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5909,ML00006641,,,O=C1CCc2ccc(O)c(c2)Oc2ccc(cc2)C(Sc2ccccc2)CCO1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5910,ML00004524,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCc3cc4c5c(c3)c(=O)c(C(=O)O)cn5COC4)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5911,ML00005259,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CCNCCNc2cc3c(=O)c(C(=O)O)cn(C4CC4)c3cc2Cl)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2ccnc3ccccc23)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5912,ML00000387,CHEMBL432990,,O=C1NCCCC[C@@H](C(=O)NCC(=O)N2CCOCC2)NC(=O)[C@H](Cc2ccc(-c3c(F)cccc3F)cc2)[C@@H](C(=O)NO)CCCO1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5913,ML00005416,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCNCCOCCOCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5914,ML00000443,CHEMBL1682726,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCCN2CCOCC2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5915,ML00003368,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5916,ML00006728,,,COc1ccc2cc1Oc1ccc(cc1)C(Sc1ccccc1)CCOC(=O)CC2,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5917,ML00000655,CHEMBL3218563,,CSCC[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)N[C@H](CC(C)C)[C@@H](O)CC(=O)O2,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5918,ML00001286,CHEMBL2029744,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2ccc3ccccc3n2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5919,ML00003555,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5920,ML00001670,CHEMBL2029745,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2ccc3ccccc3n2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5921,ML00002616,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(C#CCOC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5922,ML00004598,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3ccc4c(=O)c(C(=O)O)cn(C5CC5)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5923,ML00006263,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ccc(C(=O)OCc5ccccc5)cc4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5924,ML00000574,CHEMBL1682457,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccc(C(C)C)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5925,ML00005393,,,CCOC(=O)c1cn(CC)c2ccc(C#CCN3CCN(CCC(=O)O[C@H]4[C@H](C)O[C@@H](O[C@H]5[C@H](C)[C@@H](O[C@@H]6O[C@H](C)C[C@H](N(C)C)[C@H]6O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]5C)C[C@@]4(C)OC)CC3)cc2c1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5926,ML00005384,,,CCOC(=O)c1cn(CC)c2ccc(CCCN3CCN(CCC(=O)O[C@H]4[C@H](C)O[C@@H](O[C@H]5[C@H](C)[C@@H](O[C@@H]6O[C@H](C)C[C@H](N(C)C)[C@H]6O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]5C)C[C@@]4(C)OC)CC3)cc2c1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5927,ML00000468,CHEMBL4089929,,C=C1/C=C/C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)O[C@H]([C@H](C)CCCCCC)[C@@H](CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5928,ML00009737,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)[C@H](N)[C@H](C)CN(C)CCOC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5929,ML00000272,CHEMBL3775684,,C=C1/C=C/C(=O)N(C)CC(=O)N[C@@H]([C@H](O)C(=O)OC)C(=O)O[C@@H]([C@H](C)CCCCCCCCCCCC(C)C)[C@H](C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5930,ML00003835,,,C#C[C@@]1(O)[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5931,ML00000496,CHEMBL1682464,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(-n3cccn3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5932,ML00000699,CHEMBL4082065,,C=C1/C=C/C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5933,ML00004613,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCNCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5934,ML00000344,CHEMBL1774451,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(Cc2ccc(C)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5935,ML00005853,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccc([N+](=O)[O-])cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C(=O)Nc2ccc(Cl)cc2Cl)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5936,ML00002755,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5937,ML00000413,CHEMBL1682593,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(Br)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5938,ML00002590,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC)[C@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5939,ML00006149,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccc(O)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5940,ML00004800,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(NC(=O)CCCCCCC(=O)NO)cc3)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5941,ML00004440,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3ccccc3-c3cn(CCCCCCC(=O)NO)nn3)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5942,ML00000575,CHEMBL1682450,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccc3c(c2)OCCCO3)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5943,ML00000508,CHEMBL1682443,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NC(c2ccccc2)(c2ccccc2)c2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5944,ML00003977,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccco1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5945,ML00000503,CHEMBL1682587,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccc(OCc3ccccc3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5946,ML00000429,CHEMBL1682460,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccc(Cl)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5947,ML00006280,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(Cc2ccc(-c3cn(CCC(=O)NO)nn3)cc2)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5948,ML00000458,CHEMBL1682592,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc3c(c2)OCO3)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5949,ML00006135,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccc(O)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5950,ML00002737,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4ccccc4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5951,ML00004384,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=S)Nc2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5952,ML00002504,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccco1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5953,ML00000557,CHEMBL1682599,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(OC)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5954,ML00001009,CHEMBL1835659,SPIRUCHOSTATIN C,CC[C@H](C)[C@H]1NC(=O)[C@H]2CSSCC/C=C/[C@H](CC(=O)N[C@H](CC[S+](C)[O-])C(=O)N2)OC(=O)C[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5955,ML00001451,CHEMBL3601567,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCCc2cn(CCn3ccc4cc(F)ccc43)nn2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5956,ML00002113,CHEMBL88656,,COc1ccc2c(CCNC(=O)[C@@H]3CCCCNC(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N3)c[nH]c2c1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5957,ML00004428,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCOCCNc3cc4c(=O)c(C(=O)O)cn(CC)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5958,ML00001540,CHEMBL3601575,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(Cc2ccc(-c3cn(CCn4ccc5ccccc54)nn3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5959,ML00004610,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5960,ML00000448,CHEMBL1682444,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2cccc([N+](=O)[O-])c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5961,ML00004548,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN(C)CCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5962,ML00010631,,,CC[C@H](C)[C@@H]1OC(=O)C(C)(C)[C@@H](O)[C@@H](Cc2ccccc2)OC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)c2cccc(N)c2O)[C@H](C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5963,ML00003787,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN2/C(=N\Cc3ccccc3)O[C@H]([C@H]2C)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5964,ML00006193,,,CC(=O)OC[C@@]12[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]3OC(=O)[C@](C)(OC(=O)c4ccccc4)CCc4ncccc4C(=O)OC[C@]4(C)O[C@@]1([C@@H](OC(=O)c1ccccc1)[C@H]4[C@@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5965,ML00004702,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccc([N+](=O)[O-])cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5966,ML00002027,CHEMBL330547,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)Nc2nc(CC(=O)N3CCOCC3)cs2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5967,ML00000455,CHEMBL1774623,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCNC(=O)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5968,ML00002081,CHEMBL303590,,O=C(NC(Cc1ccccc1)C(O)CN1CCCCCCCCCCCCOC1=O)O[C@H]1CO[C@H]2OCC[C@@H]12,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5969,ML00000420,CHEMBL1682455,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(F)c(F)c2F)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5970,ML00008029,,,C[C@H]1CCCCCCCCCCCCC(=O)O1,standard_macrolactone,15.0,,,success,,1.0,[3],ring_size_15/standard/numbered/ML00008029_numbered.png,2026-03-19 06:57:38.732658
5971,ML00004583,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)(CN(C)C)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3ccc(-c4cn(CCCCCC(=O)NO)nn4)cc3)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5972,ML00005552,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4ccnc5ccccc45)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5973,ML00008679,,,COc1c(O)cc2cc1Oc1ccc(cc1)CCCOC(=O)/C=C\2,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
5974,ML00001437,CHEMBL1774449,,C=CO[C@]1(C)C[C@@H](C)CN(C(=O)NCC)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5975,ML00007051,,,CSCC[C@@H]1NC(=O)C[C@H]2/C=C\CCSSC[C@H](NC1=O)C(=O)N[C@@H](C(C)C)[C@@H](O)CC(=O)O2,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5976,ML00006553,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5977,ML00006294,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCC(=O)Nc3ccc([N+](=O)[O-])cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5978,ML00004212,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5979,ML00003857,,,C=CCN1C[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C(N)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5980,ML00003757,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)Nc2cccc(F)c2)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5981,ML00001766,CHEMBL328483,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)Nc2ccncc2)CCCCN(C)C(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5982,ML00000945,CHEMBL1946399,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCCNC(=O)CCCNc3ccnc4cc(Cl)ccc34)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5983,ML00006510,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5984,ML00001193,CHEMBL3774614,,C=C1/C=C/C(=O)N(C)CC(=O)N[C@H]([C@@H](O)C(N)=O)C(=O)O[C@H]([C@@H](C)CCCCCCCCCCCC(C)C)[C@@H](C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5985,ML00001449,CHEMBL3601458,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCCc2cn(CCn3ccc4cc(Cl)ccc43)nn2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5986,ML00004547,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCC(=O)NCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5987,ML00000485,CHEMBL1682700,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCCCSC)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5988,ML00006276,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(C4CCCCC4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5989,ML00003419,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2OC(=O)N3C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H]2OC(=O)O[C@@]21C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5990,ML00001038,CHEMBL2313363,spiruchostatin D,CC(C)[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)N[C@H](C(C)C)[C@@H](O)CC(=O)O2,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5991,ML00005570,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4ccnc5ccccc45)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5992,ML00009686,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CCC(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5993,ML00000416,CHEMBL1682578,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccc(F)c(F)c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5994,ML00000445,CHEMBL1682703,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)NCCc2cccs2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5995,ML00005358,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccc(OC)cc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5996,ML00000225,CHEMBL1774584,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=O)Nc2ccc(Cl)cc2Cl)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5997,ML00003980,,,CC(=O)OCC12C(OC(C)=O)C(OC(C)=O)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1CCC(C)C(=O)OC(C(OC(=O)c1ccoc1)C2OC(C)=O)C4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5998,ML00005610,,,CC(=O)OCC12C(OC(C)=O)C(OC(C)=O)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1CCC(C)(OC(=O)c1ccoc1)C(=O)OC(C(OC(=O)c1ccoc1)C2OC(C)=O)C4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5999,ML00006548,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4ccc(-c5ccccc5)cc4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6000,ML00002147,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)NC(=O)[C@H](C)[C@@H]2OC(=O)O[C@@]21C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6001,ML00002111,CHEMBL90850,,Cc1ccc2[nH]cc(CCNC(=O)[C@@H]3CCCCNC(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N3)c2c1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6002,ML00003911,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(Cc4ccccn4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6003,ML00003640,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6004,ML00005202,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4N(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6005,ML00006032,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6006,ML00000005,CHEMBL529,AZITHROMYCIN,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6007,ML00006427,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NC3CCCCC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6008,ML00005368,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN(C)CCNc3cc4c(=O)c(C(=O)NCCO)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6009,ML00000426,CHEMBL1682716,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)NC2CCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6010,ML00000434,CHEMBL1682575,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(OC(F)F)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6011,ML00007726,,,O=C1CCc2ccc(cc2)Oc2cc(ccc2O)CCCO1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6012,ML00000431,CHEMBL1682572,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2cccc(F)c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6013,ML00002223,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(=O)[C@H](C)CCc4ncccc4C(=O)OC[C@@]4(C)O[C@@]1([C@H]3C)[C@@H](OC(C)=O)[C@@H]4[C@H](OC(=O)c1cccnc1)[C@@H]2OC(C)=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6014,ML00005321,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccccc4Cl)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(OC)cc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6015,ML00003435,,,CCCCCNC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6016,ML00009761,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(=O)[C@@](C)(O)CCc4ncccc4C(=O)OC[C@@]4(C)O[C@]1([C@H](OC(C)=O)[C@@H]4C(=O)[C@@H]2OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6017,ML00005757,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCNC(C)C(=O)Nc2ccc([N+](=O)[O-])cc2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6018,ML00002083,CHEMBL315393,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCC(N3CCCCC3)CC2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6019,ML00003907,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCc2ccc([N+](=O)[O-])cc2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6020,ML00004461,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(NC(=O)CCCCCCC(=O)OC)cc3)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6021,ML00003317,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6022,ML00004441,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(Cc2ccc(-c3cn(CCCCCCC(=O)NO)nn3)cc2)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6023,ML00005261,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CCNCCNc2cc3c(=O)c(C(=O)O)cn(C4CC4)c3cc2Cl)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6024,ML00005237,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCOCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6025,ML00006241,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCNC(=O)c3ccc(Cl)cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6026,ML00007251,,,C=C1CC[C@H](Br)[C@@]2(C)CC[C@H]3O[C@@]3(C)CC[C@@H](C(C)(C)O)OC(=O)c3ccc(O)c(c3)C[C@H]12,standard_macrolactone,15.0,,,success,,3.0,"[3, 6, 10]",ring_size_15/standard/numbered/ML00007251_numbered.png,2026-03-19 06:57:39.216810
6027,ML00001908,CHEMBL4092563,,C=C1/C=C/C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCOCc2ccccc2)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6028,ML00007250,,,C=C1CC[C@H](Br)[C@@]2(C)CC[C@@H]3O[C@@]3(C)CC[C@@H](C(C)(C)O)OC(=O)c3ccc(O)c(c3)C[C@H]12,standard_macrolactone,15.0,,,success,,3.0,"[3, 6, 10]",ring_size_15/standard/numbered/ML00007250_numbered.png,2026-03-19 06:57:39.254087
6029,ML00005305,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCNC(=O)c3ccc(C)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6030,ML00006240,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccc([N+](=O)[O-])cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C2OC(=O)OC12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6031,ML00000457,CHEMBL1682730,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCCCl)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6032,ML00003141,,,CC(=O)OCC12C(OC(C)=O)C(OC(C)=O)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1CCC(C)C(=O)OC(C(OC(C)=O)C2OC(=O)c1ccccc1)C4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6033,ML00005553,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNC2CN(S(=O)(=O)c3ccc4ccncc4c3)CCN2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6034,ML00003508,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)Nc2cccc(C)c2)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6035,ML00005260,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CCNCCNc2cc3c(=O)c(C(=O)O)cn(C4CC4)c3cc2Cl)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2ccc3ncccc3c2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6036,ML00004214,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6037,ML00006033,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6038,ML00005249,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCCCCOC#Cc3ccc4c(c3)c(=O)c(C(=O)O)cn4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6039,ML00000390,CHEMBL3352928,,CC(C)CCCCCCCCCCC[C@@H](C)[C@@H]1OC(=O)[C@@H]([C@@H](O)C(N)=O)NC(=O)CN(C)C(=O)CCC(C)NC(=O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6040,ML00001287,CHEMBL2159135,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2O/C(=N\C(C)(C)C)N3C)[C@](C)(OC)C[C@@H](C)C(=O)N[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6041,ML00004409,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@H](NC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)OCC2c3ccccc3-c3ccccc32)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6042,ML00003928,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ccc(C(N)=O)cn4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6043,ML00009314,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(O)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6044,ML00000957,CHEMBL2029753,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCC(=O)NCCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6045,ML00000881,CHEMBL1946398,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCCNC(=O)CCCNc3ccnc4cc(Cl)ccc34)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6046,ML00000516,CHEMBL2041395,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OCCCN(C)Cc2ccnc3ccccc23)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6047,ML00009397,,,CC[C@H](C)[C@@H]1OC(=O)[C@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC(=O)[C@H]([C@@H](C)CC)OC(=O)C(C)(C)[C@@H](O)[C@@H](Cc2ccccc2)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6048,ML00001736,CHEMBL419865,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)N[C@H](CO)C(=O)N2CCOCC2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6049,ML00006303,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccc(Cl)cc4Cl)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6050,ML00000486,CHEMBL1682721,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NC2CC2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6051,ML00007106,,,CC[C@H](O)C[C@@H]1CC[C@H](O)[C@@H](C)C(=O)O[C@@H](C)C[C@@H]2CC[C@@H](O2)[C@@H](C)C(=O)O1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6052,ML00005821,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4cnc5ccccc5c4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6053,ML00001051,CHEMBL1554628,,CO[C@H]1COC(=O)[C@H]2CCCN2C(=O)[C@@H](C)COC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6054,ML00009764,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3C(=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CCC(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6055,ML00006266,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC[C@@H](O)CN2CCN(c3ccc4c(c3F)c(=O)c(C(=O)O)cn4C3CC3)CC2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6056,ML00008824,,,CC(C)[C@@H]1OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@H](C)OC(=O)[C@H](C(C)C)OC(=O)C(C)(C)[C@@H](O)[C@@H](Cc2ccccc2)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6057,ML00000117,CHEMBL1526429,,CO[C@H]1COC(=O)C/C=C\[C@@H](C)COC(=O)[C@@H](OCc2ccccc2)/C=C\[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6058,ML00002193,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cccc3ccccc23)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6059,ML00006118,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ccc(C(=O)OCc5ccccc5)cc4F)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6060,ML00005194,,,CCOC(=O)c1cn(C2CC2)c2ccc(CCCN3CCN(CCC(=O)O[C@H]4[C@H](C)O[C@@H](O[C@H]5[C@H](C)[C@@H](O[C@@H]6O[C@H](C)C[C@H](N(C)C)[C@H]6O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]5C)C[C@@]4(C)OC)CC3)cc2c1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6061,ML00003632,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6062,ML00001103,CHEMBL3775034,,COC(=O)[C@@H](O)[C@@H]1NC(=O)CN(C)C(=O)/C=C/[C@H](CO)NC(=O)[C@@H](C)[C@H]([C@@H](C)CCCCCCCCCCCC(C)C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6063,ML00004512,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)(CN(C)Cc3ccc(-c4cn(CCCCCCC(=O)NO)nn4)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6064,ML00003074,,,CCCCNC[C@@]1(O)[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6065,ML00001767,CHEMBL3650143,,CC(=O)SCC/C=C/[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N[C@H](C)C(=O)N[C@H](C(C)C)[C@@H](O)CC(=O)O1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6066,ML00006207,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccc(C#N)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C2OC(=O)OC12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6067,ML00006254,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN2/C(=N\c3cccc4ccccc34)O[C@H]([C@H]2C)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6068,ML00002927,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN(C)C[C@H](COc3ccccc3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6069,ML00004552,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccccc3OC)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccccc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6070,ML00004582,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6071,ML00007615,,,CO/N=C\C=C/C(=O)N/C=C/C[C@H]1CC(=O)O[C@@H](CO)/C=C\[C@@H](O)/C(C)=C\Cc2cccc(O)c2C(=O)O1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6072,ML00005417,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccc(F)cc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6073,ML00002276,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ccc(C#N)cc4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6074,ML00003671,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4nccs4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6075,ML00005220,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCc3cc4c5c(c3)c(=O)c(C(=O)O)cn5C(C)(C)OC4)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6076,ML00009581,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C(=S)Nc2cccc(C(F)(F)F)c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6077,ML00000515,CHEMBL1682452,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(S(=O)(=O)N3CCCCC3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6078,ML00004681,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccc(F)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6079,ML00002578,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCCNc3ccnc4ccccc34)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6080,ML00004574,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3ccc4c(=O)c(C(=O)O)cn(CC)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6081,ML00005593,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCNCCCCc2ccccc2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6082,ML00003804,,,CCCCCCNC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6083,ML00009059,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)n2ccnc2)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6084,ML00004460,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCC(=O)Nc3ccc4ccccc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6085,ML00003755,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6086,ML00002735,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4cccc(OC)c4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6087,ML00000569,CHEMBL2041392,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OCCCNCc2ccnc3ccccc23)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6088,ML00009766,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6089,ML00003592,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6090,ML00010321,,,C=C1CC(=O)N[C@@H](C)C(=O)N(C)[C@@H](C(C)C)C(=O)NCC(=O)O[C@H](/C(C)=C/C(C)=C/C(C)(C)C)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6091,ML00005427,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCN3CCN(CCCc4ccc5c(c4)c(=O)c(C(=O)O)cn5CC)CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6092,ML00004897,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCC(=O)Nc3cccc4ncccc34)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6093,ML00005226,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3cc4c(cc3F)c(=O)c(C(=O)NCCO)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6094,ML00010764,,,CCCCCCCCCCCCC[C@@H]1CCCCCCCC(=O)OC[C@H]2O[C@@H](O1)[C@H](O)[C@@H](OC(C)=O)[C@@H]2O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6095,ML00000087,CHEMBL1329939,,Cc1ccc(S(=O)(=O)N[C@H]2COC(=O)C/C=C\[C@@H](C)COC(=O)C/C=C\[C@@H]2C)cc1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6096,ML00004821,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)CCN(CCCc4ccnc5ccccc45)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(C)=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6097,ML00003398,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4cncc(Cl)n4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6098,ML00007616,,,CO/N=C/C=C\C(=O)N/C=C/C[C@H]1CC(=O)O[C@@H](CO)/C=C\[C@@H](O)/C(C)=C\Cc2cccc(O)c2C(=O)O1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6099,ML00006059,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccc4c(c3)OCO4)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6100,ML00001654,CHEMBL3601581,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCCc2cn(CC)nn2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6101,ML00004713,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN3CCN(C(=O)c4ccco4)CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6102,ML00003933,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4cccs4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6103,ML00003759,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2cccc(Cl)c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6104,ML00001535,CHEMBL3601576,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(Cc2ccc(-c3cn(CCn4ccc5cc(Cl)ccc54)nn3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6105,ML00005889,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN(C)C[C@@H](COCc3ccccc3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6106,ML00004717,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3ccc(-c4cn(CCCC(=O)NO)nn4)cc3)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6107,ML00004649,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccccc4C)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6108,ML00006052,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3cncc([N+](=O)[O-])c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6109,ML00005806,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCNC(C)Cc2ccccc2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6110,ML00001106,CHEMBL3775820,,COC(=O)[C@@H](O)[C@@H]1NC(=O)CN(C)C(=O)/C=C/[C@H](CO)NC(=O)[C@H](C)[C@@H]([C@@H](C)CCCCCCCCCCCC(C)C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6111,ML00006509,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6112,ML00006162,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=O)NC(C)c2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6113,ML00001735,CHEMBL86542,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCCC(=O)N2CCOCC2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6114,ML00005667,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=O)Nc2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6115,ML00001993,CHEMBL4068836,,C=C1/C=C/C(=O)N[C@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCOCc2ccc(OC)cc2)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6116,ML00000513,CHEMBL1682585,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NC2CCCCCCCCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6117,ML00002646,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2ccccc2C)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6118,ML00006296,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccc(Cl)cc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6119,ML00000893,CHEMBL2029754,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCC(=O)NCc2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6120,ML00005818,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCNC(C)Cc2ccc([N+](=O)[O-])cc2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6121,ML00009684,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6122,ML00002098,CHEMBL292373,,CC1CCCCCCCCCCOC(=O)N(CC(O)C(Cc2ccccc2)NC(=O)O[C@H]2CO[C@H]3OCC[C@@H]23)C1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6123,ML00002693,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CN2CCN(c3cccc(C(F)(F)F)c3)CC2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6124,ML00006255,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccccc3F)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C2OC(=O)OC12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6125,ML00000885,CHEMBL2041382,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OCCCNC(=O)CNc2ccnc3ccccc23)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6126,ML00005383,,,CCOC(=O)c1cn(C2CC2)c2ccc(C#CCN3CCN(CCC(=O)O[C@H]4[C@H](C)O[C@@H](O[C@H]5[C@H](C)[C@@H](O[C@@H]6O[C@H](C)C[C@H](N(C)C)[C@H]6O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]5C)C[C@@]4(C)OC)CC3)cc2c1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6127,ML00000887,CHEMBL2029755,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCC(=O)N[C@H](C)c2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6128,ML00006685,,,CC[C@H]1C[C@H]2CC[C@H](O2)[C@H](C)C(=O)O[C@H](C[C@H](O)CC)CC[C@@H](O)[C@@H](C)C(=O)O1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6129,ML00007107,,,CC[C@@H](O)C[C@@H]1CC[C@@H](O)[C@@H](C)C(=O)O[C@@H](C)C[C@H]2CC[C@H](O2)[C@H](C)C(=O)O1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6130,ML00000838,CHEMBL2041571,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OCCCN(C)Cc2cnc3ccccc3c2)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6131,ML00004517,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6132,ML00000428,CHEMBL1682729,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2c(C)noc2C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6133,ML00000539,CHEMBL2041570,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OCCCN(C)Cc2cnc3ccccc3c2)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6134,ML00004043,,,O=C1OC[C@H]2O[C@@H](O)[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]3[C@@H]2OC(=O)c2cc(O)c(O)c3oc(=O)c4cc(O)c(c(O)c4c23)Oc2c1cc(O)c(O)c2O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6135,ML00005232,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(F)cc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6136,ML00005242,,,CCOC(=O)c1cn(CC)c2ccc(N3CCN(CCO[C@H]4[C@H](C)O[C@@H](O[C@H]5[C@H](C)[C@@H](O[C@@H]6O[C@H](C)C[C@H](N(C)C)[C@H]6O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]6OC(=O)O[C@]6(C)[C@@H](CC)OC(=O)[C@@H]5C)C[C@@]4(C)OC)CC3)cc2c1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6137,ML00003409,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4ccco4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6138,ML00010756,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]([N+](C)(C)[O-])[C@H]2O)[C@](C)(OCC2CO2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6139,ML00002910,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NC(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6140,ML00000369,CHEMBL1590173,,CO[C@H]1COC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)COC(=O)CCC[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6141,ML00000504,CHEMBL1682448,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2cccc(-c3ccccc3)c2OC)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6142,ML00004599,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3cccs3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccc(OC)cc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6143,ML00006589,,,C=C1/C=C\C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCC)[C@@H](CCO)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6144,ML00004211,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CSC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6145,ML00002581,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ccccc4[N+](=O)[O-])CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6146,ML00007725,,,O=C1CCc2ccc(O)c(c2)Oc2ccc(cc2)CCCO1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6147,ML00001616,CHEMBL2029597,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2ccccn2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6148,ML00001764,CHEMBL328479,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCc2ccccn2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6149,ML00005215,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3ccc4c(c3)c(=O)c(C(=O)NCCO)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6150,ML00004533,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@H](N(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)OCC2c3ccccc3-c3ccccc32)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6151,ML00004216,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6152,ML00009590,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)n2ccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6153,ML00002450,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNc2cnc3ccccc3c2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6154,ML00005432,,,CCCn1cc(C(=O)O)c(=O)c2cc(CCCOCCOCCC(=O)O[C@H]3[C@H](C)O[C@@H](O[C@H]4[C@H](C)[C@@H](O[C@@H]5O[C@H](C)C[C@H](N(C)C)[C@H]5O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]4C)C[C@@]3(C)OC)ccc21,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6155,ML00003326,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CN)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6156,ML00000564,CHEMBL1682710,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)NCc2ccc(OC)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6157,ML00000232,CHEMBL532024,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6158,ML00003637,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]3OC(=O)[C@@H](C)CCc4ncccc4C(=O)OC[C@@]4(C)O[C@@]1([C@@H](OC(C)=O)[C@H]4[C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6159,ML00000440,CHEMBL1682449,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6160,ML00009788,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C(=O)Nc2ccc(Cl)cc2Cl)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6161,ML00004495,,,CCCCCNC(=O)O[C@@H]1[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccc(OC)cc3)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6162,ML00005317,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCCCOCC#Cc3ccc4c(c3)c(=O)c(C(=O)O)cn4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6163,ML00010772,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)N[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6164,ML00010322,,,C=C1CC(=O)N[C@@H](C)C(=O)N(C)[C@@H](C(C)C)C(=O)NCC(=O)O[C@H](/C(C)=C/C(C)=C/C(C)(C)C)[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6165,ML00002575,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CN[C@H](C)Cc2ccccc2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6166,ML00001553,CHEMBL2029756,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Cc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6167,ML00000217,CHEMBL1774630,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCNC(=O)NC(C)c2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6168,ML00005296,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN(C)CCNc3ccc4c(c3)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6169,ML00008683,,,COc1ccc2cc1Oc1ccc(cc1)CC(I)COC(=O)CC2,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6170,ML00004618,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccc([N+](=O)[O-])cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccccc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6171,ML00000561,CHEMBL1682605,,CCc1ccccc1NC(=S)NCCCN1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6172,ML00004558,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccc(Cl)cc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6173,ML00002553,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(Cc4ccccn4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6174,ML00004650,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4cccc(C)c4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6175,ML00005229,,,CCCOC(=O)c1cn(C2CC2)c2ccc(NCCOCCC(=O)O[C@H]3[C@H](C)O[C@@H](O[C@H]4[C@H](C)[C@@H](O[C@@H]5O[C@H](C)C[C@H](N(C)C)[C@H]5O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]4C)C[C@@]3(C)OC)cc2c1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6176,ML00003057,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN(C)C[C@H](c3ccccc3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6177,ML00003841,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](OC)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6178,ML00003336,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)N(C)C[C@@H](C)C[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6179,ML00000943,CHEMBL3314703,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(OC(=O)c1ccoc1)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6180,ML00003756,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)Nc2ccc(F)cc2)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6181,ML00005668,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=O)Nc2ccc3ccccc3c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6182,ML00006302,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4c(Cl)cccc4Cl)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6183,ML00004600,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](N(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)OCC2c3ccccc3-c3ccccc32)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6184,ML00005289,,,CCCn1cc(C(=O)O)c(=O)c2cc(CCCOCCCO[C@H]3[C@H](C)O[C@@H](O[C@H]4[C@H](C)[C@@H](O[C@@H]5O[C@H](C)C[C@H](N(C)C)[C@H]5O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]4C)C[C@@]3(C)OC)ccc21,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6185,ML00000466,CHEMBL4101716,,C=C1/C=C/C(=O)N[C@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6186,ML00006136,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/NCCc2ccc([N+](=O)[O-])cc2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6187,ML00002978,,,CC(=O)OCC12C(OC(C)=O)C(OC(=O)c3ccccc3)C3OC(=O)C(C)CCc4ncccc4C(=O)OCC4(C)OC1(C3C)C(OC(C)=O)C4C(OC(C)=O)C2OC(C)=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6188,ML00004525,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCNc3ccc4c(c3)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6189,ML00004622,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccc(Br)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccccc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6190,ML00005250,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(F)c(F)c2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6191,ML00005319,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN(C)CCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6192,ML00004515,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCN3CCN(c4ccc5c(c4)c(=O)c(C(=O)O)cn5CC)CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6193,ML00006556,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccccc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6194,ML00004403,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6195,ML00003758,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2ccccc2Cl)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6196,ML00003641,,,CC(=O)OCC12C(OC(C)=O)C(OC(C)=O)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1CCC(C)C(=O)OC(C(OC(C)=O)C2OC(C)=O)C4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6197,ML00002213,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1cccnc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6198,ML00001144,CHEMBL3774958,,COC(=O)[C@@H](O)[C@@H]1NC(=O)CN(C)C(=O)/C=C/[C@H](CO)NC(=O)[C@@H](C)[C@H]([C@H](C)CCCCCCCCCCCCC(C)C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6199,ML00000424,CHEMBL3824087,,COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc2ccc3cc(-c4ccc(-c5c[nH]c([C@@H]6C[C@@H]7CN6C(=O)[C@H](C(C)C)NC(=O)OCCCCCCO7)n5)cc4)ccc3c2[nH]1)C(C)C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6200,ML00002110,CHEMBL88291,,COc1ccc2[nH]cc(CCNC(=O)[C@@H]3CCCCNC(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N3)c2c1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6201,ML00001849,CHEMBL3358521,,C[C@@H]1CCCC(=O)N(C)/C=C/CC[C@@H](C)C(=O)O[C@@H](C(C)(C)C)C1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6202,ML00000568,CHEMBL2041394,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OCCCNCc2ccc3ccccc3n2)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6203,ML00005244,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCC(=O)NCCOCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6204,ML00007279,,,C=C(C)[C@@H]1CC[C@](C)(O)[C@H](Br)CC[C@]2(C)[C@@H](Br)CC=C(C)[C@H]2Cc2cc(ccc2O)C(=O)O1,standard_macrolactone,15.0,,,success,,5.0,"[3, 6, 6, 7, 10]",ring_size_15/standard/numbered/ML00007279_numbered.png,2026-03-19 06:57:40.678085
6205,ML00006478,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCO[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6206,ML00006047,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6207,ML00003077,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CCCOC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6208,ML00000388,CHEMBL324550,,O=C1NCCCC[C@@H](C(=O)NCC(=O)N2CCOCC2)NC(=O)[C@H](Cc2ccc(-c3cc(Cl)cc(Cl)c3)cc2)[C@@H](C(=O)NO)CCCO1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6209,ML00004475,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@H](N)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)OCC2c3ccccc3-c3ccccc32)[C@](C)(O)C[C@@H](C)N(CCF)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6210,ML00005817,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCN(C)CCc2ccc([N+](=O)[O-])cc2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6211,ML00009502,,,O=C1CCSC2=C(SCCC(=O)OCC3(CO1)COC(=O)CCSC1=C(SCCC(=O)OC3)C(=O)c3ccccc3C1=O)C(=O)c1ccccc1C2=O,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6212,ML00001284,CHEMBL2029747,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2cnc3ccccc3c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6213,ML00000228,CHEMBL1774636,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCNC(=S)Nc2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6214,ML00003361,,,CC(=O)OC[C@@]12[C@H](O)[C@@H](OC(C)=O)[C@H]3[C@@H](OC(C)=O)[C@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@H]([C@@H](OC(=O)c1ccoc1)[C@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6215,ML00008431,,,CC(C)[C@H]1NC(=O)[C@H]2CSSCC/C=C/[C@H](CC(=O)N[C@H](C)C(=O)N2)OC(=O)C[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6216,ML00009313,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CCC(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6217,ML00004728,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCNC(=O)c3ccccc3OC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6218,ML00003795,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](OC(=O)C=C)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)C=C)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6219,ML00000614,CHEMBL464946,ANTILLATOXIN,C=C1CC(=O)N[C@@H](C)C(=O)N(C)[C@@H](C(C)C)C(=O)NCC(=O)O[C@@H](/C(C)=C/C(C)=C/C(C)(C)C)[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6220,ML00004566,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCOc3ccc4c(c3)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6221,ML00002217,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(=O)c1ccccc1)C4(C)C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6222,ML00003434,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2OC(=O)N3CC)[C@](C)(OC)C[C@@H](C)C(=O)N[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6223,ML00003853,,,CCCN1C[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6224,ML00008438,,,CC(C)[C@@H]1NC(=O)[C@@H]2CSSCC/C=C\[C@@H](CC(=O)N[C@H](C)C(=O)N2)OC(=O)C[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6225,ML00003745,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN2/C(=N\Cc3ccccc3)O[C@H]([C@H]2C)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6226,ML00001958,CHEMBL3680942,,COc1ccc2c(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)O)C[C@H]5/C=C\CCCCCOC(=O)N4C3)cc(-c3ccccc3)nc2c1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6227,ML00005354,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNC(=O)CCNCCOCCOCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6228,ML00004213,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6229,ML00003183,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6230,ML00000478,CHEMBL2041387,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OCCCNC(=O)CCCNc2ccnc3cc(Cl)ccc23)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6231,ML00002006,CHEMBL3314702,,CC(=O)O[C@H]1[C@@H](O)[C@]2(CO)[C@@H](O)[C@@H](O)[C@@H]3OC(=O)[C@@](C)(OC(=O)c4ccoc4)CCc4ncccc4C(=O)OC[C@]4(C)O[C@@]2([C@H](OC(C)=O)[C@@H]14)[C@@]3(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6232,ML00009692,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(C)(O)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6233,ML00004715,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccc(C)cc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6234,ML00003098,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(C#CCN(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6235,ML00009700,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6236,ML00000439,CHEMBL1682446,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2cccc(C(F)(F)F)c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6237,ML00004400,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccccc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(F)cc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6238,ML00006042,,,CCCCCCCC(=O)NCCCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@]2(C)O)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6239,ML00009699,,,CC(=O)OCC12C(OC(C)=O)C(O)C3OC(=O)C(C)CCc4ncccc4C(=O)OCC4(C)OC1(C(OC(C)=O)C4C(OC(C)=O)C2OC(C)=O)C3(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6240,ML00003844,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6241,ML00002566,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCCCc2cccnc2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6242,ML00000148,CHEMBL115263,,NC(=O)CNC(=O)[C@@H]1CCCCNC(=O)OCCC[C@H](C(=O)NO)[C@@H](Cc2ccc(-c3ccccc3C(F)(F)F)cc2)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6243,ML00001850,CHEMBL88427,,CNC(=O)[C@@H]1CCCCN(C)C(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6244,ML00001309,CHEMBL2159133,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2O/C(=N\C(C)C)N3C)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6245,ML00005293,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCOCCNc3ccc4c(c3)c(=O)c(C(=O)O)cn4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6246,ML00003510,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)Nc2ccccc2C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6247,ML00006333,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4cccnc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6248,ML00010114,,,CC(C)C[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6249,ML00003509,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2ccccc2C)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6250,ML00004408,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccccc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6251,ML00000551,CHEMBL1682725,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCCN2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6252,ML00004534,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCN3CCN(c4ccc5c(c4)c(=O)c(C(=O)O)cn5CC)CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6253,ML00006224,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ccc(C(=O)OCc5ccccc5)c(C(F)(F)F)c4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6254,ML00001105,CHEMBL3774976,,COC(=O)[C@H](O)[C@H]1NC(=O)CN(C)C(=O)/C=C/[C@@H](CO)NC(=O)[C@@H](C)[C@H]([C@H](C)CCCCCCCCCCCC(C)C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6255,ML00001541,CHEMBL3601580,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(Cc2ccc(-c3cn(CCN4CCc5ccccc54)nn3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6256,ML00009505,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6257,ML00005241,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6258,ML00002600,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CNC3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6259,ML00004904,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCC(=O)Nc3ccc4ccccc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6260,ML00003887,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4ccccn4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6261,ML00007465,,,CC1=C2Cc3cc(ccc3O)C(=O)OC(C)(C)[C@H](Br)C[C@]3(C)O[C@H]3CC[C@]2(C)[C@@H](Br)CC1,standard_macrolactone,15.0,,,success,,5.0,"[3, 3, 4, 6, 10]",ring_size_15/standard/numbered/ML00007465_numbered.png,2026-03-19 06:57:41.273441
6262,ML00003856,,,CCC[C@@]1(O)[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6263,ML00009466,,,CCCCNC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6264,ML00010725,,,C=CCO[C@]1(C)C[C@@H](C)C(=O)N[C@H](C)[C@H](O)[C@@](C)(O)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6265,ML00002618,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4ccccn4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6266,ML00000211,CHEMBL1774640,,CCOC(=O)CCN(CCN1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C)C(=O)Nc1ccc2ccccc2c1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6267,ML00001651,CHEMBL2029765,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)c2ocnc2C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6268,ML00007767,,,O=C1CCc2ccc(OP(=O)(O)O)c(c2)Oc2ccc(cc2)/C=C\CO1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6269,ML00001578,CHEMBL1813069,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(OC(C)=O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6270,ML00002059,CHEMBL327831,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCC(O)CC2)CCCCN(C)C(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6271,ML00002431,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2ccnc3ccccc23)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6272,ML00000873,CHEMBL2314997,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@H]2[C@H](C)C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@@]32C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6273,ML00004557,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6274,ML00007403,,,CC[C@@H]1/C=C\[C@H](O)[C@H](C)OC(=O)C2(C)C=CC(=O)NC3=C2C(=O)c2c(cc(C)c(O)c2C(=O)CC1)C3=O,standard_macrolactone,15.0,,,success,,6.0,"[3, 4, 7, 10, 13, 15]",ring_size_15/standard/numbered/ML00007403_numbered.png,2026-03-19 06:57:41.423226
6275,ML00004899,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCC(=O)Nc3ccc4cccnc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6276,ML00010193,,,O=C1OC[C@H]2O[C@@](CO)(O[C@H]3O[C@H](COC(=O)[C@H]4[C@@H]1[C@@H](c1ccc(O)cc1)[C@@H]4c1ccc(O)cc1)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@@H]2O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6277,ML00000444,CHEMBL1682706,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)NC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6278,ML00004889,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3cc(OC)c(OC)c(OC)c3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C2OC(=O)OC12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6279,ML00005300,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN(C)CCNc3ccc4c(c3)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6280,ML00005326,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccc(Cl)cc4Cl)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(OC)cc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6281,ML00003556,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6282,ML00008031,,,CC[C@H]1CCCC/C=C\CCCC(=O)OCCN1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6283,ML00004816,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCN2CCN(c3cc4c(cc3F)c(=O)c(C(=O)OC)cn4C3CC3)CC2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6284,ML00000544,CHEMBL1682702,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccc(C(C)=O)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6285,ML00005355,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNC(=O)CCNCCOCCOCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6286,ML00007158,,,C/C1=C/[C@H]2C[C@H](C)[C@H](O2)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O[C@H](/C(C)=C/c2csc(C)n2)C[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6287,ML00010827,,,CC[C@H]1/C=C\[C@H](O)[C@H](C=C(C)C)OC(=O)[C@]2(C)C=CC(=O)NC3=C2C(=O)c2c(cc(C)c(O)c2C(=O)CC1)C3=O,standard_macrolactone,15.0,,,success,,6.0,"[3, 4, 7, 10, 13, 15]",ring_size_15/standard/numbered/ML00010827_numbered.png,2026-03-19 06:57:41.570365
6288,ML00003958,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6289,ML00003016,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6290,ML00003619,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6291,ML00006713,,,C[C@H]1/C=C\[C@@H](O)/C=C(/Cl)CCOC(=O)C2=CC[C@H]3CCC[C@]4(CCC[C@H]14)N3C2,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6292,ML00002511,,,CC(=O)OCC12C(OC(C)=O)C(OC(C)=O)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1CCC(C)(O)C(=O)OC(C(OC(=O)c1ccoc1)C2OC(C)=O)C4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6293,ML00002929,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)CN(C)C[C@H](COCc3ccccc3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6294,ML00005470,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccc([N+](=O)[O-])cc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6295,ML00005422,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@H]2CC[C@H]3[C@@H]4CCC5=CC(=O)CC[C@]5(C)[C@H]4[C@@H](O)C[C@]23C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6296,ML00003982,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6297,ML00002597,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CN(C)CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6298,ML00003207,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6299,ML00005787,,,CCOc1ccccc1N1CCN(CC(O)CO[C@]2(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@H]2O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)CC1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6300,ML00007938,,,O=C1CCCCCC=CCCOC(=O)c2c(O)cc(O)c(Cl)c2C1,standard_macrolactone,15.0,,,success,,1.0,[12],ring_size_15/standard/numbered/ML00007938_numbered.png,2026-03-19 06:57:41.688518
6301,ML00005511,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6302,ML00003959,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6303,ML00000484,CHEMBL1682722,,CCC(C)NC(=O)NCCCN1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6304,ML00003811,,,CCCN1C(=O)O[C@H]2[C@H](O[C@@H]3[C@@H](C)[C@H](O[C@H]4C[C@@](C)(OC)[C@@H](O)[C@H](C)O4)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@]3(C)O)O[C@H](C)C[C@@H]21,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6305,ML00005313,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccc(OC)c(OC)c3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccccc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6306,ML00004265,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4cccnc4Cl)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6307,ML00000487,CHEMBL1682708,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6308,ML00003335,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)C[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6309,ML00009688,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6310,ML00003232,,,CC[C@@H](C)C(=O)O[C@H]1[C@@H](OC(C)=O)[C@@H]2OC(=O)[C@](C)(OC(C)=O)CCc3ncccc3C(=O)OC[C@]3(C)O[C@@]4([C@H](OC(C)=O)[C@H]3[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@]14COC(C)=O)[C@@]2(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6311,ML00001732,CHEMBL89045,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCC(O)CC2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6312,ML00001214,CHEMBL2159139,,CC/N=C1\O[C@H]2[C@H](O[C@@H]3[C@@H](C)[C@H](O[C@H]4C[C@@](C)(OC)[C@@H](O)[C@H](C)O4)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@]3(C)O)O[C@H](C)C[C@@H]2N1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6313,ML00003333,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@](C)(O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6314,ML00004601,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)(CN(C)Cc3ccc(-c4cn(CCCCCC(=O)NO)nn4)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6315,ML00004210,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CCO)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6316,ML00004457,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3ccc4c(=O)c(C(=O)O)cn(C)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6317,ML00000330,CHEMBL558355,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)NC(C)c2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6318,ML00006942,,,C[C@H]1CCCC[C@@H](C)C(=O)N(C)/C=C\CC(=O)O[C@@H](C(C)(C)C)C1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6319,ML00004805,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(Cc2ccc(-c3cn(CCCCCC(=O)NO)nn3)cc2)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6320,ML00004496,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccccc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6321,ML00003913,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(Cc4cccnc4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6322,ML00011013,,,CC[C@H]1OC(=O)C[C@@H](O)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)C[C@H](N(C)C)[C@H]2O)[C@H]2C[C@@H](C)c3cc(ncc32)[C@@]2(C)O[C@H]2[C@@H]1C,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6323,ML00000052,CHEMBL431680,,O=C1NCCCC[C@@H](C(=O)NCC(=O)N2CCNCC2)NC(=O)[C@H](Cc2ccc(-c3ccccc3C(F)(F)F)cc2)[C@@H](C(=O)NO)CCCO1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6324,ML00004866,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCN2CCN(c3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)CC2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6325,ML00010726,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@](C)(O)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6326,ML00001111,CHEMBL3775955,,C=C1/C=C/C(=O)N(C)CC(=O)N[C@H]([C@@H](O)C(=O)OC)C(=O)O[C@H]([C@@H](C)CCCCCCCCCCCC(C)C)[C@@H](C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6327,ML00006215,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccc(Br)cc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6328,ML00008859,,,CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)OC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6329,ML00002104,CHEMBL4088208,,C=C1/C=C/C(=O)N[C@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCOC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6330,ML00004858,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCN2CCN(c3ccc4c(c3)c(=O)c(C(=O)O)cn4C3CC3)CC2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6331,ML00005308,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCOCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6332,ML00004362,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3ccc4c(=O)c(C(=O)O)cn(C)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6333,ML00007991,,,CC1COC(=O)CCCCCCCCC(=O)OC1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6334,ML00001448,CHEMBL3601454,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCCc2cn(CCc3c[nH]c4ccc(Cl)cc34)nn2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6335,ML00006157,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccccc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6336,ML00001457,CHEMBL2314754,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@@]2(O)[C@H](C)C[C@H]3[C@@H]4CCC5=CC(=O)CC[C@]5(C)[C@H]4[C@@H](O)C[C@@]32C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6337,ML00000540,CHEMBL2041391,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OCCC(=O)NCCNc2ccnc3cc(Cl)ccc23)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6338,ML00005505,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN(C)[C@@H](CCOCc3ccccc3)COC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6339,ML00005980,,,CCCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]3OC(=O)O[C@]3(C)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6340,ML00003002,,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]3[C@@H](OC(C)=O)[C@]14O[C@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6341,ML00000338,CHEMBL3823642,,COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc3oc(-c4ccc(-c5c[nH]c([C@@H]6C[C@@H]7CN6C(=O)[C@H](C(C)C)NC(=O)OC/C=C/CCCO7)n5)cc4)cc3c2)[nH]1)C(C)C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6342,ML00006153,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccccc3OC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6343,ML00003743,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)Nc2ccccc2)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6344,ML00004279,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4cncc(Cl)c4Cl)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6345,ML00005415,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2Cl)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6346,ML00005568,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6347,ML00002377,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCc2cnc3ccccc3c2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6348,ML00004718,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(Cc2ccc(-c3cn(CCCC(=O)NO)nn3)cc2)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6349,ML00003331,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6350,ML00001860,CHEMBL211494,,CN1C2CCC1C1COC(=O)CCCCC(=O)Nc3ccc(cc3)C1C2,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6351,ML00002596,,,CCCNC[C@@]1(O)[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6352,ML00001478,CHEMBL2029757,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)CCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6353,ML00000205,CHEMBL1774633,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCNC(=S)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6354,ML00003491,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)Nc2cccc(OC)c2)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6355,ML00000227,CHEMBL1774629,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCNC(=O)Nc2ccc3ccccc3c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6356,ML00004546,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN(C)CCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6357,ML00004215,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6358,ML00008119,,,CO[C@@H]1COC(=O)[C@@H](C)COC(=O)[C@@H](C)NC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6359,ML00001913,CHEMBL4059964,,C=C1/C=C/C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCOC(=O)[Si](C)(C)C(C)(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6360,ML00004567,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6361,ML00002730,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4ccc(Cl)cc4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6362,ML00003851,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@](O)(CN(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6363,ML00005286,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4CCOC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6364,ML00005816,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4ccc(C#N)cc4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6365,ML00000966,CHEMBL2029589,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNc2ccnc3cc(Cl)ccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6366,ML00005435,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN(C)CCNc3cc4c(cc3F)c(=O)c(C(=O)NCCO)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6367,ML00003934,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4cc(CO)cc(Cl)n4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6368,ML00002551,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ccc(N)cc4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6369,ML00000545,CHEMBL1682720,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccc3c(c2)CCO3)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6370,ML00004691,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(Cc2ccc(-c3cn(CCCCC(=O)NO)nn3)cc2)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6371,ML00004410,,,C=CCN1C[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](N)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)OCC2c3ccccc3-c3ccccc32)[C@](C)(O)C[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6372,ML00003193,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]3OC(=O)[C@@](C)(OC(=O)c4ccccc4)CCc4ncccc4C(=O)OC[C@]4(C)O[C@]1([C@H](O)[C@@H]4[C@@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6373,ML00003497,,,CC[C@H]1OC(=O)CC2(O)C(C=O)[C@@H](C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@@H](C)[C@@H](O)[C@@H](OC)[C@@H]1OC)[C@H](O[C@@H]1O[C@@H](C)[C@@H](O)[C@@H](N(C)C)[C@H]1O)[C@H]2C,standard_macrolactone,15.0,,,success,,7.0,"[3, 4, 6, 9, 10, 13, 14]",ring_size_15/standard/numbered/ML00003497_numbered.png,2026-03-19 06:57:42.279805
6374,ML00002979,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@H]4C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6375,ML00009689,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(O)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6376,ML00000192,CHEMBL1774292,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(Cc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6377,ML00000498,CHEMBL540229,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=O)Nc2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6378,ML00010527,,,CC(C)C[C@@H]1NC(=O)[C@H](CC(C)C)OC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6379,ML00004588,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCNCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6380,ML00004736,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccccc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6381,ML00010518,,,CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CC(C)C)OC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6382,ML00000587,CHEMBL4093985,,C=C1/C=C/C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)O[C@H]([C@@H](C)CCCCCC)[C@@H](CCO)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6383,ML00005468,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccccc3OC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6384,ML00004806,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3ccccc3-c3cn(CCCCCC(=O)NO)nn3)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6385,ML00010320,,,C=C1CC(=O)N[C@@H](C)C(=O)N(C)[C@@H](C(C)C)C(=O)NCC(=O)O[C@@H](/C(C)=C/C(C)=C/C(C)(C)C)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6386,ML00006524,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc(Br)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6387,ML00003102,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(C#CCOC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6388,ML00000572,CHEMBL563603,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6389,ML00001436,CHEMBL557931,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)N[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6390,ML00002564,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CN)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C2OC(=O)OC12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6391,ML00006944,,,C[C@H]1CCCC(=O)N(C)/C=C/CC[C@@H](C)C(=O)O[C@H](C(C)(C)C)C1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6392,ML00006532,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc(Cl)cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6393,ML00006444,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ncc(C(=O)OCc5ccccc5)c(C(F)(F)F)n4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6394,ML00002612,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN2/C(=N\C(C)C)O[C@H]([C@H]2C)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6395,ML00005299,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CCNCCNc2cc3c(=O)c(C(=O)O)cn(C4CC4)c3cc2Cl)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccccc3n2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6396,ML00002451,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNc2ccc3ncccc3c2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6397,ML00000548,CHEMBL1946557,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCCNc3ccnc4ccc(Cl)cc34)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6398,ML00006110,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(Cc4ccc(-c5ccccc5)cc4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6399,ML00005801,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=S)NCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6400,ML00000190,CHEMBL1774637,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCNC(=S)NCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6401,ML00005302,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCOCCNc3ccc4c(c3)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6402,ML00010626,,,CC(C)[C@@H]1OC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6403,ML00002758,,,CCOC(=O)c1ccc(N2CCC3(CC2)O[C@H]2[C@H](C)[C@@H](O[C@@H]4O[C@H](C)CC(N(C)C)[C@H]4O)[C@@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)O3)nc1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6404,ML00003343,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)N[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6405,ML00006298,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4cccc(Cl)c4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6406,ML00005199,,,CCCCn1cc(C(=O)O)c(=O)c2cc(CCCOCCCO[C@H]3[C@H](C)O[C@@H](O[C@H]4[C@H](C)[C@@H](O[C@@H]5O[C@H](C)C[C@H](N(C)C)[C@H]5O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]4C)C[C@@]3(C)OC)ccc21,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6407,ML00006535,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCNC(C)C(=O)Nc2ccc3ncccc3c2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6408,ML00004689,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)(CN(C)Cc3ccc(-c4cn(CC(=O)NO)nn4)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6409,ML00009538,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C(=S)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6410,ML00001307,CHEMBL2029588,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNc2ccnc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6411,ML00003978,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccco4)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CCC(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6412,ML00000883,CHEMBL2314755,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@@]2(O)[C@H](C)C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(Cl)[C@@H](O)C[C@@]32C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6413,ML00000215,CHEMBL562773,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=S)NCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6414,ML00002084,CHEMBL327639,,CNC(=O)[C@@H](CCCCNC(=O)OC(C)(C)C)NC(=O)[C@@H]1CCCCNC(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6415,ML00010192,,,O=C1OC[C@H]2O[C@H](O[C@]3(CO)O[C@H](COC(=O)[C@H]4[C@@H]1[C@H](c1ccc(O)cc1)[C@@H]4c1ccc(O)cc1)[C@@H](O)[C@@H]3O)[C@H](O)[C@@H](O)[C@@H]2O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6416,ML00000888,CHEMBL2029760,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Cc2ccc3ccccc3c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6417,ML00000231,CHEMBL1774635,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCNC(=S)NCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6418,ML00003840,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6419,ML00005247,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3cc(OC)c(OC)c(OC)c3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccccc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6420,ML00002338,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CN2CCN(c3ccc([N+](=O)[O-])cc3)CC2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6421,ML00007731,,,O=C1CCc2ccc(OP(=O)(O)O)c(c2)Oc2ccc(cc2)/C=C\CO1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6422,ML00010525,,,CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)OC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6423,ML00003506,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2cccc(C)c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6424,ML00010732,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6425,ML00003273,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)N(C)C)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CCC(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6426,ML00007052,,,CSCC[C@@H]1NC(=O)C[C@@H]2/C=C\CCSSC[C@@H](NC1=O)C(=O)N[C@@H](C(C)C)[C@H](O)CC(=O)O2,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6427,ML00005992,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN(C)[C@@H](COCc3ccccc3)COC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6428,ML00005550,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4ccc5ccccc5n4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6429,ML00006521,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3cc([N+](=O)[O-])cc([N+](=O)[O-])c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6430,ML00006281,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3ccc(-c4cn(CCC(=O)NO)nn4)cc3)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6431,ML00008685,,,COc1ccc2cc1Oc1ccc(cc1)CCCOC(=O)CC2,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6432,ML00003981,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6433,ML00000552,CHEMBL1682579,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(Oc3ccccc3)nc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6434,ML00004658,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN2/C(=N\c3ccc(-c4ccccc4)cc3OC)O[C@H]([C@H]2C)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6435,ML00005760,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CN2CCN(c3ccc(C(C)=O)cc3)CC2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6436,ML00004202,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@](C)(O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6437,ML00006586,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CSSCC/C=C\[C@H](CC(=O)N[C@@H](CCSC)C(=O)N2)OC(=O)C[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6438,ML00004497,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccc(F)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6439,ML00004559,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6440,ML00000543,CHEMBL1682600,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCc2ccc3c(c2)OCO3)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6441,ML00008916,,,CCCCCCCCCCCCC[C@H]1OC(=O)[C@H](COC(C)=O)NC(=O)[C@@H]([C@H](C)OS(=O)(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6442,ML00002593,,,CC#C[C@@]1(O)[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6443,ML00005463,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCCCCOCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6444,ML00006148,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6445,ML00006536,,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCNC(C)C(=O)Nc2cnc3ccccc3c2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6446,ML00000456,CHEMBL1682724,,CCNC(=O)NCCCN1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6447,ML00003049,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(c3ccccn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6448,ML00007618,,,CON1O/C=C\C=C(N)/C=C\C[C@@H]2CC(=O)O[C@H](C)/C=C\[C@@H](O)/C(C)=C\Cc3cccc(c3C(=O)O2)O1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6449,ML00005472,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccccc4F)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6450,ML00000348,CHEMBL1774453,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6451,ML00000542,CHEMBL1682727,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCCCN2CCOCC2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6452,ML00001874,CHEMBL90499,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(F)(F)F)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6453,ML00010115,,,CC(C)C[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)OC(=O)[C@H](Cc2ccccc2)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6454,ML00000763,CHEMBL2029590,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNc2ccnc3cc(Cl)ccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6455,ML00009600,,,CC[C@H]1OC(=O)/C(C)=C\[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN(C(=O)Nc2ccc(Cl)cc2Cl)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6456,ML00005430,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN(C)CCNc3ccc4c(c3)c(=O)c(C(=O)NCCO)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6457,ML00007506,,,C/C=C/C/C=C/[C@H](C)C[C@H](O)[C@H]1C[C@@H]2O[C@H]2/C=C\[C@@H](O)[C@@H](O)/C=C\C[C@H](C)CC(=O)O1,standard_macrolactone,15.0,,,success,,4.0,"[3, 9, 10, 14]",ring_size_15/standard/numbered/ML00007506_numbered.png,2026-03-19 06:57:42.906166
6458,ML00000091,CHEMBL1836042,,CCCC[C@H]1NC(=O)C[C@@H](/C=C/CCS)OC(=O)C[C@H](O)[C@@H]([C@@H](C)CC)NC(=O)[C@@H](CS)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6459,ML00004903,,,COc1ccc(C[C@@H](C(=O)O[C@H](C)C(NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](C)O)C(=O)N2CCCCNC(=O)[C@H](C)C(=O)[C@H](C(C)C)OC(=O)C[C@H](O)[C@H]2CC(C)C)N(C)C(C)=O)cc1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6460,ML00008106,,,O=C1CCCCCCCCCCOCCO1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6461,ML00005284,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCCCNc3ccc4c(=O)c(C(=O)O)cn(CC)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6462,ML00002210,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1cccnc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6463,ML00001071,CHEMBL1363122,,CCC[C@H]1CCCC/C=C\CCCC(=O)OCCN1C(=O)OC(C)(C)C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6464,ML00006477,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCO[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6465,ML00004535,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCNC(=O)c3cc([N+](=O)[O-])cc([N+](=O)[O-])c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6466,ML00007277,,,C=C(C)[C@@H]1CC[C@](C)(O)[C@H](Br)CC[C@@]2(C)C(=C(C)CC[C@@H]2Br)Cc2cc(ccc2O)C(=O)O1,standard_macrolactone,15.0,,,success,,5.0,"[3, 6, 6, 7, 10]",ring_size_15/standard/numbered/ML00007277_numbered.png,2026-03-19 06:57:42.997516
6467,ML00004508,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6468,ML00009576,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C(=O)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6469,ML00003191,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(OC(=O)c1ccco1)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6470,ML00001614,CHEMBL1774299,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN(C(=O)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6471,ML00006832,,,CCCC[C@H]1NC(=O)C[C@H]2/C=C\CCSSC[C@@H](NC1=O)C(=O)N[C@H]([C@H](C)CC)[C@@H](O)CC(=O)O2,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6472,ML00001110,CHEMBL3774666,,C=C1/C=C/C(=O)N(C)CC(=O)N[C@@H]([C@H](O)C(=O)OC)C(=O)O[C@H]([C@@H](C)CCCCCCCCCCCC(C)C)[C@@H](C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6473,ML00006397,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN2/C(=N\Cc3ccccc3)O[C@H]([C@H]2C)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6474,ML00000541,CHEMBL2041381,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OCCCNC(=O)CNc2ccnc3cc(Cl)ccc23)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6475,ML00002430,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)N[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6476,ML00003274,,,CC(=O)OC[C@]12[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@]3(C)CCOC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6477,ML00010661,,,CC(C)C[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)OC(=O)[C@H](Cc2ccccc2)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6478,ML00010638,,,CC(C)[C@H]1OC(=O)C(C)(C)[C@H](O)[C@H](Cc2ccccc2)OC(=O)[C@@H](C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6479,ML00002897,,,CC[C@H]1CCC(=O)O[C@H]2[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]3(COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]4[C@@H](OC(=O)c5ccccc5)[C@]3(O[C@@]4(C)COC(=O)c3cccnc31)[C@@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6480,ML00004592,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCCCNc3ccc4c(=O)c(C(=O)O)cn(C)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6481,ML00002550,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4cc(OC)nc(OC)n4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6482,ML00008676,,,COc1c(O)cc2cc1Oc1ccc(cc1)/C=C\COC(=O)/C=C\2,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6483,ML00005580,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2O/C(=N/Cc2ccccc2)N3C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6484,ML00000517,CHEMBL1945161,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCNCCOCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6485,ML00009762,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CCC(C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6486,ML00001873,CHEMBL3358525,,C[C@@H]1CCCC(=O)N(C)/C=C/CC[C@@H](C)C(=O)O[C@H](C(C)(C)C)C1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6487,ML00004651,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccc(C)cc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6488,ML00009491,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN(C)CCOC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6489,ML00003345,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@]3(CO3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6490,ML00006653,,,CC1=CC[C@H]2C(C)(C)[C@@H]3CC[C@@]2(C)[C@@H]1CC/C(C)=C\COC(=O)CC(=O)O3,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6491,ML00002286,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=O)Nc2ccc(Cl)cc2Cl)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6492,ML00006545,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ccc(S(=O)(=O)c5ccc(F)cc5)cc4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6493,ML00000578,CHEMBL2041389,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OCCCNc2ccnc3ccccc23)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6494,ML00005487,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN(C)C[C@H](CCOCc3ccccc3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6495,ML00006031,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCO[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6496,ML00003105,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6497,ML00000514,CHEMBL1682588,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCC23CC4CC(CC(C4)C2)C3)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6498,ML00003842,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6499,ML00004737,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccccc3OC)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C2OC(=O)OC12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6500,ML00000660,CHEMBL1521010,,Cc1ccc(S(=O)(=O)N[C@H]2COC(=O)[C@H](C)COC(=O)[C@H](C)NC(=O)C/C=C\[C@H]2C)cc1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6501,ML00004514,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCCCNc3ccc4c(=O)c(C(=O)O)cn(C)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6502,ML00001285,CHEMBL2029750,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2ccnc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6503,ML00001346,CHEMBL4083178,,C#CCCCCCCCCC(=O)OCC[C@@H]1C(=O)N[C@@H](CO)/C=C/C(=O)N[C@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@H]1[C@H](C)CCCCCC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6504,ML00008686,,,COc1ccc2cc1Oc1ccc(cc1)CC(O)COC(=O)CC2,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6505,ML00001869,CHEMBL2313364,spiruchostatin B,CCC(C)[C@H]1NC(=O)[C@H]2CSSCC/C=C/[C@H](CC(=O)N[C@H](C)C(=O)N2)OC(=O)C[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6506,ML00000493,CHEMBL1682707,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6507,ML00005925,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN(C)C[C@H](COCc3ccccc3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6508,ML00000695,CHEMBL1774583,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6509,ML00004344,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2ccccc2F)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6510,ML00000987,CHEMBL1081435,BROMOPHYCOLIDE S,C=C1CC[C@H](Br)[C@@]2(C)CC[C@@H]3O[C@@]3(C)CC[C@@H](C(C)(C)Br)OC(=O)c3ccc(O)c(c3)C[C@H]12,standard_macrolactone,15.0,,,success,,3.0,"[3, 6, 10]",ring_size_15/standard/numbered/ML00000987_numbered.png,2026-03-19 06:57:43.327648
6511,ML00010125,,,C/C=C1/NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)OC(=O)[C@H](Cc2ccccc2)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6512,ML00009527,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]3NC(=O)O[C@H]32)[C@](C)(OC)C[C@@H](C)C(=O)N[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6513,ML00005527,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NC3CCCCC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6514,ML00001762,CHEMBL89512,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)Nc2cccnc2)CCCCN(C)C(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6515,ML00007543,,,C/C=C\C/C=C\[C@H](C)C[C@H](O)[C@H]1C[C@@H]2O[C@H]2/C=C\[C@@H](O)[C@@H](O)/C=C\C[C@H](C)CC(=O)O1,standard_macrolactone,15.0,,,success,,4.0,"[3, 9, 10, 14]",ring_size_15/standard/numbered/ML00007543_numbered.png,2026-03-19 06:57:43.386501
6516,ML00004411,,,C=CCN1C[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@H](N)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)OCC2c3ccccc3-c3ccccc32)[C@](C)(O)C[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6517,ML00000877,CHEMBL2041386,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OCCCNC(=O)CCCNc2ccnc3ccccc23)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6518,ML00003282,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2ccc(C(F)(F)F)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6519,ML00000020,CHEMBL2315001,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@H]2[C@H](C)C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@@]32C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6520,ML00000476,CHEMBL1682719,,CCCCNC(=O)NCCCN1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6521,ML00003593,,,CC(=O)OC[C@@]12[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]3[C@@H](OC(C)=O)[C@]14O[C@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6522,ML00009697,,,CC[C@H](C)[C@@H]1OC(=O)C(C)(C)[C@H](O)[C@H](Cc2ccccc2)OC(=O)[C@H](C(C)C)OC(=O)[C@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6523,ML00004648,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccc(OC)c(OC)c3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C2OC(=O)OC12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6524,ML00009690,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6525,ML00007402,,,CC[C@H]1/C=C\[C@H](O)[C@H](C)OC(=O)[C@@]2(C)C=CC(=O)NC3=C2C(=O)c2c(cc(C)c(O)c2C(=O)CC1)C3=O,standard_macrolactone,15.0,,,success,,6.0,"[3, 4, 7, 10, 13, 15]",ring_size_15/standard/numbered/ML00007402_numbered.png,2026-03-19 06:57:43.493354
6526,ML00006258,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccc(Br)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C2OC(=O)OC12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6527,ML00008575,,,CO[C@@H]1/C=C\CC(=O)N2CCC[C@@H]2C(=O)OC[C@@H](C)C(=O)OC[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6528,ML00002099,CHEMBL62182,,CC1CCCCCCCCCCCOC(=O)N1CC(O)C(Cc1ccccc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@@H]12,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6529,ML00005464,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNCCCNCCOCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6530,ML00006154,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc(C)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6531,ML00007249,,,C=C1CCC(C)=C2Cc3cc(ccc3O)C(=O)O[C@H](C(C)(C)O)CC[C@](C)(O)[C@H](Br)CC[C@@H]12,standard_macrolactone,15.0,,,success,,4.0,"[3, 6, 6, 7]",ring_size_15/standard/numbered/ML00007249_numbered.png,2026-03-19 06:57:43.560753
6532,ML00003362,,,CC(=O)OC[C@]12[C@H](O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6533,ML00008891,,,CCCCCCCCCCCCC[C@@H]1OC(=O)[C@H](COC(C)=O)NC(=O)[C@H]([C@@H](C)OS(=O)(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)[C@@H](O)[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6534,ML00006156,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccccc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6535,ML00007671,,,C=C1/C=C\C(=O)N(C)CC(=O)N[C@H](CCC(N)=O)C(=O)O[C@H]([C@@H](C)C[C@@H](C)CC(C)C)[C@@H](C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6536,ML00001470,CHEMBL2029752,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCC(=O)NCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6537,ML00003321,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)C(C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6538,ML00003633,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6539,ML00006839,,,C=C1CC/C=C\[C@H](O)[C@H](C)/C=C\[C@@H](O)[C@@H]([C@H](C)/C=C/CCC)OC(=O)C[C@H]1C,standard_macrolactone,15.0,,,success,,6.0,"[3, 4, 7, 8, 13, 14]",ring_size_15/standard/numbered/ML00006839_numbered.png,2026-03-19 06:57:43.645587
6540,ML00006246,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccccc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C2OC(=O)OC12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6541,ML00004719,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=S)Nc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6542,ML00003201,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(=O)[C@H](C)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6543,ML00003206,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6544,ML00006287,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCCNc3ccnc4ccccc34)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6545,ML00007258,,,CC1=C2Cc3cc(ccc3O)C(=O)O[C@H](C(C)(C)O)CC[C@](C)(O)[C@H](Br)CC[C@]2(C)[C@@H](Br)CC1,standard_macrolactone,15.0,,,success,,5.0,"[3, 6, 6, 7, 10]",ring_size_15/standard/numbered/ML00007258_numbered.png,2026-03-19 06:57:43.718260
6546,ML00007388,,,CC[C@H]1/C=C\[C@@H](O)[C@H](C)OC(=O)[C@@]2(C)C=CC(=O)NC3=C2C(=O)c2c(cc(C)c(O)c2C(=O)CC1)C3=O,standard_macrolactone,15.0,,,success,,6.0,"[3, 4, 7, 10, 13, 15]",ring_size_15/standard/numbered/ML00007388_numbered.png,2026-03-19 06:57:43.756936
6547,ML00006144,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCC(=O)Nc3ccc([N+](=O)[O-])cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6548,ML00010266,,,CO[C@]1(C)C[C@@H](C)[C@H](O)[C@H](C)CN(C)CCOC(=O)C(C)C(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6549,ML00006152,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6550,ML00006648,,,CCC(C)C1NC(=O)C(C(C)C)OC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C(C)C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6551,ML00006554,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccc(O)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6552,ML00009744,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCNCC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6553,ML00008969,,,C=CCO[C@]1(C)C[C@@H](C)C(=O)N[C@H](C)[C@H](O)[C@@](C)(OCC=C)[C@@H](CC)OC(=O)[C@H](C)C(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6554,ML00003976,,,O=C1OC[C@@H]2O[C@H](O)[C@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]3[C@@H]2OC(=O)c2cc(O)c(O)c3oc(=O)c4cc(O)c(c(O)c4c23)Oc2c1cc(O)c(O)c2O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6555,ML00003318,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6556,ML00004900,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCC(=O)Nc3cnc4ccccc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6557,ML00002914,,,CCCCCNC(=O)O[C@@H]1[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](OC(=O)Nc2ccccc2)[C@@H](C)C(=O)O[C@H](CC)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6558,ML00003452,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4ccc[nH]4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6559,ML00003013,,,CC(=O)OCC12C(OC(C)=O)C(OC(C)=O)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1CCC(C)C(=O)OC(C(OC(=O)c1ccccc1)C2OC(C)=O)C4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6560,ML00005389,,,CCOC(=O)c1cn(CC)c2ccc(C#CCN3CCN(CCC(=O)O[C@H]4[C@H](C)O[C@@H](O[C@H]5[C@H](C)[C@@H](O[C@@H]6O[C@H](C)C[C@H](N(C)C)[C@H]6O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]5C)C[C@@]4(C)OC)CC3)cc2c1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6561,ML00006209,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccc(Cl)cc4Cl)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6562,ML00005673,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(C)cc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6563,ML00002645,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N(C)c2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6564,ML00005273,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCOCCNc3cc4c(=O)c(C(=O)O)cn(C(C)C)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6565,ML00002736,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4ccc(OC)cc4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6566,ML00005800,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4ccc(OC)cc4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6567,ML00003838,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC)[C@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6568,ML00009111,,,C=CCNC(=S)N1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6569,ML00007622,,,CO/N=C/C=C/C(=O)N/C=C/C[C@@H]1CC(=O)O[C@@H](C)/C=C\[C@@H](O)/C(C)=C\Cc2cccc(O)c2C(=O)O1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6570,ML00002508,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6571,ML00000446,CHEMBL1682610,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccsc2C(=O)OC)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6572,ML00005200,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6573,ML00002955,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CN3CCCCC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6574,ML00006205,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CN2CCN(c3ccc4c(c3F)c(=O)c(C(=O)OC)cn4C3CC3)CC2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6575,ML00003824,,,CCCN1C(=O)O[C@H]2[C@H](O[C@@H]3[C@@H](C)[C@H](O[C@H]4C[C@@](C)(OC)[C@@H](O)[C@H](C)O4)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)NC(=O)[C@H](C)C[C@@]3(C)OC)O[C@H](C)C[C@@H]21,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6576,ML00004442,,,CCCCCNC(=O)O[C@@H]1[C@@H](C)N(C)C[C@H](C)C[C@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccccc3Cl)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6577,ML00004528,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6578,ML00005239,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCOc3ccc4c(c3)c(=O)c(C(=O)OC(C)C)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6579,ML00000756,CHEMBL4097663,,C=C1/C=C/C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCOCc2ccc(OC)cc2)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6580,ML00001834,CHEMBL1742349,,CO[C@H]1COC(=O)[C@@H](C)COC(=O)[C@H](C)NC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6581,ML00003975,,,CC(=O)OCC12C(OC(C)=O)C(OC(C)=O)C3C(O)C14OC3(C)COC(=O)c1cccnc1CCC(C)C(=O)OC(C(OC(=O)c1ccccc1)C2OC(C)=O)C4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6582,ML00004463,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccco3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccccc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6583,ML00001851,CHEMBL3358524,,C[C@H]1CCCCN(C)C(=O)CCC[C@@H](C)C[C@H](C(C)(C)C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6584,ML00003875,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4nccc(C(F)(F)F)n4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6585,ML00008939,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C(=O)NC(C)(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6586,ML00006108,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/NCCc2ccc([N+](=O)[O-])cc2)C[C@@H](C)C(=O)N[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6587,ML00005221,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCc3cc4c5c(c3)c(=O)c(C(=O)O)cn5C(C)(C)CO4)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6588,ML00003296,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2cccc(C(F)(F)F)c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6589,ML00003179,,,CC(=O)OCC12C(OC(C)=O)C(OC(C)=O)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1CCC(C)(O)C(=O)OC(C(OC(=O)c1ccccc1)C2OC(C)=O)C4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6590,ML00004690,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=O)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6591,ML00003733,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2OC(=O)N3C)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H]2OC(=O)O[C@@]21C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6592,ML00003464,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4nccc(C(F)(F)F)n4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6593,ML00000449,CHEMBL1682590,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2cccc(F)c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6594,ML00003985,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6595,ML00001912,CHEMBL4098378,,C=C1/C=C/C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCOC(=O)[Si](CC)(CC)CC)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6596,ML00002579,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CN[C@H](C)Cc2ccc([N+](=O)[O-])cc2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6597,ML00005301,,,CCCn1cc(C(=O)O)c(=O)c2cc(NCCOCCOCCC(=O)O[C@H]3[C@H](C)O[C@@H](O[C@H]4[C@H](C)[C@@H](O[C@@H]5O[C@H](C)C[C@H](N(C)C)[C@H]5O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]4C)C[C@@]3(C)OC)c(Cl)cc21,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6598,ML00005263,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3cc4c(=O)c(C(=O)NCCO)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6599,ML00004594,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccc(O)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6600,ML00003929,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4ccco4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6601,ML00000664,CHEMBL1528606,,CO[C@H]1COC(=O)[C@H](C)COC(=O)[C@@H](Cc2ccccc2)NC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6602,ML00000505,CHEMBL1682589,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(OCc3ccccc3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6603,ML00005258,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CCNCCNc2cc3c(=O)c(C(=O)O)cn(C4CC4)c3cc2Cl)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cccc3ncccc23)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6604,ML00000250,CHEMBL1554887,,CO[C@H]1COC(=O)C/C=C\[C@H](C)COC(=O)[C@@H](OCc2ccccc2)/C=C\[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6605,ML00004985,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6606,ML00000891,CHEMBL2029759,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)CCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6607,ML00001754,CHEMBL1081114,BROMOPHYCOLIDE T,CC1=C2Cc3cc(ccc3O)C(=O)OC(C)(C)[C@H](Br)CC[C@]3(C)O[C@H]3C[C@]2(C)[C@@H](Br)CC1,standard_macrolactone,15.0,,,success,,5.0,"[3, 3, 4, 7, 10]",ring_size_15/standard/numbered/ML00001754_numbered.png,2026-03-19 06:57:44.227813
6608,ML00001318,CHEMBL1774295,,CCCN1C[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6609,ML00002021,CHEMBL1081434,BROMOPHYCOLIDE R,C=C(C)[C@@H]1CC[C@]2(C)O[C@H]2CC[C@]2(C)[C@@H](Br)CCC(=C)[C@H]2Cc2cc(ccc2O)C(=O)O1,standard_macrolactone,15.0,,,success,,3.0,"[3, 6, 10]",ring_size_15/standard/numbered/ML00002021_numbered.png,2026-03-19 06:57:44.264321
6610,ML00001799,CHEMBL1591638,,CO[C@@H]1COC(=O)[C@H]2CCCN2C(=O)[C@@H](C)COC(=O)CCC[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6611,ML00003073,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CNCC3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6612,ML00005555,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2O/C(=N/Cc2ccccc2)N3C)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6613,ML00005320,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN3CCN(c4cc5c(cc4F)c(=O)c(C(=O)O)cn5C4CC4)CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6614,ML00009191,,,C=C1CC(=O)N[C@@H](C)C(=O)N(C)[C@@H](CCc2ccccc2)C(=O)NCC(=O)O[C@@H](/C(C)=C/C(C)=C/C(C)(C)C)[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6615,ML00003320,,,CC[C@H]1OC(=O)[C@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6616,ML00005522,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6617,ML00006592,,,CC[C@H](C)[C@@H]1NC(=O)[C@H]2CSSCC/C=C\[C@H](CC(=O)N[C@@H](CCSC)C(=O)N2)OC(=O)C[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6618,ML00002617,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ccc([N+](=O)[O-])cc4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6619,ML00000395,CHEMBL323929,,CNC(=O)CNC(=O)[C@@H]1CCCCNC(=O)OCCC[C@H](C(=O)NO)[C@@H](Cc2ccc(-c3ccccc3C(F)(F)F)cc2)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6620,ML00000185,CHEMBL1774297,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN(Cc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6621,ML00005666,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ncc(C(=O)NCc5ccncc5)cn4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6622,ML00005288,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6623,ML00002554,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4ccoc4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6624,ML00001757,CHEMBL91990,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCCC2)CCCCN(C)C(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6625,ML00000579,CHEMBL2041388,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OCCCNc2ccnc3cc(Cl)ccc23)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6626,ML00003860,,,C=CC[C@@]1(O)[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6627,ML00000872,CHEMBL2315002,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@@]2(O)[C@H](C)C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@@]32C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6628,ML00003960,,,CC(=O)OCC12C(OC(C)=O)C(=O)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1CCC(C)(O)C(=O)OC(C(OC(=O)c1ccccc1)C2OC(C)=O)C4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6629,ML00005307,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNC(=O)CCNCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6630,ML00004498,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccc(F)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6631,ML00001548,CHEMBL3601579,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(Cc2ccc(-c3cn(CCn4ccc5cc(OC)ccc54)nn3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6632,ML00003643,,,CC(=O)OC[C@@]12[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3OC(=O)C(C)CCc4ccncc4C(=O)OC[C@]4(C)O[C@@]1([C@H](OC(C)=O)[C@H]4[C@@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6633,ML00001364,CHEMBL303578,,O=C(NC(Cc1ccccc1)C(O)CN1CCCCCCCCCCCC(c2ccccc2)OC1=O)O[C@H]1CO[C@H]2OCC[C@@H]12,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6634,ML00004908,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)OCCCN(CCCCc4ccccc4)C[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(C)=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6635,ML00006236,,,CCN(CCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)[C@H](N)[C@H](C)CN(C)CCOC(=O)[C@@H]2C)C[C@@]1(C)OC)[C@@H](C)c1ccccc1OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6636,ML00008947,,,CCCCCCCCCCCCC[C@H]1OC(=O)[C@H](COC(C)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6637,ML00002215,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1cccnc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6638,ML00010824,,,CC[C@H]1/C=C\[C@H](O)[C@@H](C=C(C)C)OC(=O)[C@@]2(C)C=CC(=O)Nc3c2c(O)c2c(c(O)c(C)cc2c3O)C(=O)CC1,standard_macrolactone,15.0,,,success,,6.0,"[3, 4, 7, 10, 13, 15]",ring_size_15/standard/numbered/ML00010824_numbered.png,2026-03-19 06:57:44.512621
6639,ML00004078,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ccc(C#N)cn4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6640,ML00001216,CHEMBL1774301,,C=CO[C@]1(C)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6641,ML00004809,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)N[C@H](C)[C@H](O)[C@@]1(C)OC/C=C/c1cnc2ccccc2c1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6642,ML00000665,CHEMBL1492373,,CO[C@H]1COC(=O)[C@@H](C)COC(=O)[C@@H](Cc2ccccc2)NC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6643,ML00000553,CHEMBL1682586,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)NCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6644,ML00003753,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2ccccc2F)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6645,ML00001870,CHEMBL90332,,CNC(=O)CNC(=O)[C@@H]1CCCCNC(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6646,ML00003612,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6647,ML00009334,,,CC[C@H](C)[C@@H]1OC(=O)C(C)(C)[C@@H](O)[C@@H](Cc2ccccc2)OC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@H](C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6648,ML00005438,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNC(=O)CCNCCOCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6649,ML00002957,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CN3CCCC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)C1(C)C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6650,ML00007505,,,C/C=C/C/C=C/[C@H](C)C[C@H](O)[C@H]1C[C@@H]2O[C@H]2/C=C\[C@@H](O)[C@H](O)/C=C\C[C@@H](C)CC(=O)O1,standard_macrolactone,15.0,,,success,,4.0,"[3, 9, 10, 14]",ring_size_15/standard/numbered/ML00007505_numbered.png,2026-03-19 06:57:44.623094
6651,ML00005201,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2CC(C)(OC)[C@@H](OCCCOCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4C(C)(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6652,ML00005218,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCCCNc3ccc4c(=O)c(C(=O)O)cn(C5CC5)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6653,ML00007405,,,CCC1/C=C/[C@H](O)[C@H](C)OC(=O)[C@@]2(C)C=CC(=O)NC3=C2C(=O)c2c(cc(C)c(O)c2C(=O)CC1)C3=O,standard_macrolactone,15.0,,,success,,6.0,"[3, 4, 7, 10, 13, 15]",ring_size_15/standard/numbered/ML00007405_numbered.png,2026-03-19 06:57:44.679331
6654,ML00005363,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN3CCN(CC#Cc4ccc5c(c4)c(=O)c(C(=O)O)cn5CC)CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6655,ML00000741,CHEMBL503785,,COc1ccc2c(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)NS(=O)(=O)C6CC6)C[C@H]5/C=C\CCCCCOC(=O)N4C3)cc(-c3ccccc3)nc2c1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6656,ML00000226,CHEMBL1774628,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCNC(=O)Nc2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6657,ML00003915,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4cccn4C)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6658,ML00002592,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CCCOC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6659,ML00008128,,,CO[C@@H]1COC(=O)[C@H](C)NC(=O)[C@@H](C)COC(=O)CCC[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6660,ML00008926,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN2/C(=N\C(C)C)O[C@H]([C@H]2C)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6661,ML00010613,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6662,ML00007101,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CSSCC/C=C\[C@@H](CC(=O)N[C@H](C)C(=O)N2)OC(=O)C[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6663,ML00000442,CHEMBL1682583,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(F)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6664,ML00006588,,,C=C1/C=C/C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)O[C@H]([C@@H](C)CCC)[C@@H](CCO)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6665,ML00004537,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN3CCN(c4cc5c(cc4F)c(=O)ccn5C4CC4)CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6666,ML00002956,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@](O)(CN3CCCCC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6667,ML00006616,,,C=C1[C@@H](O)C[C@@H]2C(C)(C)[C@@H]3CC[C@@]2(C)[C@@H]1CC/C(C)=C\COC(=O)CC(=O)O3,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6668,ML00003926,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4cc(C)c([N+](=O)[O-])cn4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6669,ML00000960,CHEMBL1946561,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(=O)CCCNc3ccnc4cc(Cl)ccc34)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6670,ML00000183,CHEMBL1774632,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCNC(=S)Nc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6671,ML00001463,CHEMBL3601569,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCCc2cn(CCn3ccc4cc(OC)ccc43)nn2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6672,ML00003087,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CN(C)C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6673,ML00001765,CHEMBL89426,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)Nc2ccccn2)CCCCN(C)C(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6674,ML00006271,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCc3ccc4c(c3)OCO4)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)C(C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6675,ML00000558,CHEMBL1682584,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccc(C)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6676,ML00004368,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCO[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6677,ML00000207,CHEMBL553338,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6678,ML00003319,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6679,ML00009486,,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1ncccc1C[C@H](C)[C@H](C)C(=O)O[C@H]([C@@H](OC(C)=O)[C@@H]2OC(C)=O)[C@H]4C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6680,ML00005532,,,CCCCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]3OC(=O)O[C@]3(C)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6681,ML00009683,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(O)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6682,ML00004266,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ccc(C(F)(F)F)cn4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6683,ML00006210,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4c(Cl)cccc4Cl)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6684,ML00002954,,,CCCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6685,ML00010265,,,CCCCCCCCCCCCC[C@@H]1CCCCCCCC(=O)OC[C@H]2O[C@@H](O1)[C@H](O)[C@@H](O)[C@@H]2O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6686,ML00003505,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2cccc(OC)c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6687,ML00004671,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccc(Cl)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6688,ML00000581,CHEMBL1682466,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCC2CC3CCC2C3)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6689,ML00004724,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNCCSc3cnc4ccccc4n3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6690,ML00003596,,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN(C)[C@@H](CN)COC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6691,ML00009333,,,CC[C@H](C)[C@@H]1OC(=O)C(C)(C)[C@@H](O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](C)OC(=O)[C@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6692,ML00002594,,,CCN(CC)C[C@H]1COC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6693,ML00005314,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccccc3OC)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccc(OC)cc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6694,ML00002432,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6695,ML00004431,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3ccc(OC)c(OC)c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6696,ML00003836,,,C=CCO[C@]1(C)C[C@@H](C)C(=O)N[C@H](C)[C@H](O)[C@@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6697,ML00001070,CHEMBL1599900,,CCC[C@@H]1CCCC/C=C\CCCC(=O)OCCN1C(=O)OC(C)(C)C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6698,ML00000210,CHEMBL553184,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=O)NC(C)c2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6699,ML00006519,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2cccc(C)c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(C)cc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6700,ML00002274,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4nc5ccccc5o4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6701,ML00005674,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2ccccc2C)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6702,ML00001263,CHEMBL1774303,,C=CCN1C[C@H](C)C[C@@](C)(OC=C)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6703,ML00004652,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3cc([N+](=O)[O-])cc([N+](=O)[O-])c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6704,ML00005987,,,C=C1/C=C/C(=O)N[C@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCOC(=O)CCCCCCCCCCCCCCCCC)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6705,ML00001763,CHEMBL313047,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCc2ccncc2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6706,ML00003986,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(C)C(=O)O[C@@H]([C@H](OC(=O)c1ccco1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6707,ML00007806,,,O=C1CCc2ccc(O)c(c2)Oc2ccc(cc2)[C@@H]2O[C@@H]2CO1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6708,ML00009540,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6709,ML00001608,CHEMBL442660,OPPOSITINE B,CCC1CCC(=O)O[C@H]2[C@H](OC(C)=O)[C@H](OC(=O)c3ccccc3)[C@@]3(COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]4[C@@H](OC(C)=O)[C@]3(O[C@]4(C)COC(=O)c3cccnc31)[C@@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6710,ML00003906,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4cccc(O)n4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6711,ML00006508,,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(OC(=O)c1ccoc1)C(=O)O[C@@H]([C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6712,ML00000501,CHEMBL1682603,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)NC2CCN(C(=O)OCc3ccccc3)CC2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6713,ML00004472,,,CCCCCNC(=O)O[C@@H]1[C@@H](C)N(C)C[C@H](C)C[C@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccc(OC)cc3)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6714,ML00005431,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCNCCOCCOCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6715,ML00007245,,,C=C(C)[C@@H]1CC[C@](C)(O)[C@H](Br)CC[C@H]2C(C)=CCC(C)=C2Cc2cc(ccc2O)C(=O)O1,standard_macrolactone,15.0,,,success,,4.0,"[3, 6, 6, 7]",ring_size_15/standard/numbered/ML00007245_numbered.png,2026-03-19 06:57:45.159216
6716,ML00000437,CHEMBL1682458,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccc(C(F)(F)F)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6717,ML00008942,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN(C(=O)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6718,ML00001536,CHEMBL3601573,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(Cc2ccc(-c3cn(CCc4c[nH]c5ccc(F)cc45)nn3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6719,ML00006100,,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ccc(NC(=O)c5ccccc5)cc4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6720,ML00002315,,,CCCCc1ccc(NC(=O)O[C@H]2[C@H](O[C@@H]3[C@@H](C)[C@H](O)[C@@H](C)C(=O)O[C@H](CC)[C@@]4(C)OC(=O)O[C@@H]4[C@@H](C)N(C)C[C@H](C)C[C@@]3(C)O)O[C@H](C)C[C@@H]2N(C)C)cc1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6721,ML00000489,CHEMBL1682714,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2cccs2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6722,ML00005246,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccc(OC)c(OC)c3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccc(OC)cc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6723,ML00005351,,,CCOC(=O)c1cn(CC)c2ccc(CCCN3CCN(CCC(=O)O[C@H]4[C@H](C)O[C@@H](O[C@H]5[C@H](C)[C@@H](O[C@@H]6O[C@H](C)C[C@H](N(C)C)[C@H]6O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]5C)C[C@@]4(C)OC)CC3)cc2c1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6724,ML00005455,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNC(=O)CCNCCOCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6725,ML00006265,,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC[C@H](O)CN2CCN(c3ccc4c(c3F)c(=O)c(C(=O)O)cn4C3CC3)CC2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6726,ML00004439,,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)Cc3ccc(-c4cn(CCCCCCC(=O)NO)nn4)cc3)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6727,ML00008675,,,COc1c(O)cc2cc1Oc1ccc(cc1)/C=C/COC(=O)/C=C/2,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6728,ML00005434,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCCCCOCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6729,ML00006694,,,O=C1CCCCCCCCCCC(=NOC(=O)COc2cccc([N+](=O)[O-])c2)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006694_numbered.png,2026-03-19 06:57:45.283808
6730,ML00009007,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(CC)CC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009007_numbered.png,2026-03-19 06:57:45.334875
6731,ML00008180,,,CC1CCCCCCCCCCCCCOC1=O,standard_macrolactone,16.0,,,success,,1.0,[16],ring_size_16/standard/numbered/ML00008180_numbered.png,2026-03-19 06:57:45.356903
6732,ML00004427,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2OC(C)=O)[C@@H](CCOc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004427_numbered.png,2026-03-19 06:57:45.412184
6733,ML00001381,CHEMBL435458,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)c3ccccc3NC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6734,ML00004848,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)OCCC(/C=C/Cc4cncc5ccccc45)CN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6735,ML00004894,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCOS(=O)(=O)c2ccc(C)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004894_numbered.png,2026-03-19 06:57:45.483221
6736,ML00008457,,,CC[C@@H]1OC(=O)CCC/C=C\C/C=C\C/C=C\[C@H]2[C@H]1C[C@@H](O)[C@@H]2O,standard_macrolactone,16.0,,,success,,1.0,[3],ring_size_16/standard/numbered/ML00008457_numbered.png,2026-03-19 06:57:45.506566
6737,ML00010671,,,CC(C)[C@@H]1NC(=O)[C@@H](NC(=O)c2ccccc2)[C@@H](C)OC(=O)[C@@H]2CCCCN2C(=O)[C@@H]2CCCCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6738,ML00007992,,,O=C1CCCCCCCCC(=O)OCCCCO1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6739,ML00002288,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\[C@H]2O[C@@H]2C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002288_numbered.png,2026-03-19 06:57:45.564425
6740,ML00001172,CHEMBL328208,,Cc1nc2cc([C@@H]3C[C@@H]4O[C@]4(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O3)ccc2n1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00001172_numbered.png,2026-03-19 06:57:45.612841
6741,ML00002322,,,CO[C@H]1[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@@H](CC=O)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O2)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002322_numbered.png,2026-03-19 06:57:45.658989
6742,ML00010206,,,CCC1CC(C)C(=O)/C=C\C=C/CC(C)OC(=O)CC(O)C(OC)C1OC1OC(C)CC(N(C)C)C1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010206_numbered.png,2026-03-19 06:57:45.702382
6743,ML00001325,CHEMBL103638,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c3cccc(C)c3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6744,ML00007499,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,7.0,"[3, 10, 11, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00007499_numbered.png,2026-03-19 06:57:45.751170
6745,ML00003764,,,CC[C@@H](C)[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CCCCCCCCc2ccc(O)cc2)[C@@H](C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6746,ML00006707,,,O=C1CCCCCCCCCCC(=NOC(=O)COc2ccccc2Cl)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006707_numbered.png,2026-03-19 06:57:45.781313
6747,ML00009622,,,CO[C@@H]1[C@@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](OC(C)=O)[C@H](C)O3)[C@H](N(C)C)[C@@H]2O)[C@@H](CC=O)C[C@H](C)[C@@H](O)/C=C\C=C/C[C@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009622_numbered.png,2026-03-19 06:57:45.826431
6748,ML00009317,,,COc1ccc(C[C@H]2NC(=O)/C=C\C[C@@H]([C@H](C)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6749,ML00002994,,,C=C1Oc2cc(OC)cc(C(=O)O[C@@H]3COC(=O)C[C@H](N)c4cc(O)c(c(Cl)c4)O[C@@H]4c5ccc3c(Cl)c5C3=CC=C[C@@]34O[C@H]3OC(C)(C)[C@H](N(C)C)[C@H](O)[C@@H]3O)c2NC1=O,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6750,ML00009606,,,CO[C@@H]1[C@@H](OC[C@@H]2[C@H](C)OC(=O)CC[C@@H](C)[C@@H](O[C@H]3O[C@@H](C)C[C@@]4(OC(=O)O[C@H]4C)[C@@H]3O)[C@@H](C)C[C@H](C)C(=O)/C=C\[C@@H]3O[C@H]32)O[C@@H](C)[C@@H](O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009606_numbered.png,2026-03-19 06:57:45.886877
6751,ML00009201,,,CCNCC[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](C)[C@@H](CC)OC(=O)CC(O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009201_numbered.png,2026-03-19 06:57:45.938638
6752,ML00009335,,,CC(C)C[C@@H]1OC(=O)[C@H](C)CNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)/C=C\C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6753,ML00010116,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@H](C(C)C)NC(=O)C[C@@H](/C=C/c2ccccc2)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6754,ML00007179,,,C/C1=C/C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007179_numbered.png,2026-03-19 06:57:46.001307
6755,ML00004167,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(C)CCCN(C)C(=O)CNC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004167_numbered.png,2026-03-19 06:57:46.052958
6756,ML00003060,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C(C)=O)C2O)[C@@H](CC(OC)OC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003060_numbered.png,2026-03-19 06:57:46.105708
6757,ML00007501,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,7.0,"[3, 10, 11, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00007501_numbered.png,2026-03-19 06:57:46.148752
6758,ML00005663,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc(OC)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005663_numbered.png,2026-03-19 06:57:46.201580
6759,ML00000603,CHEMBL3317810,,C[C@@]12CSC(=N1)c1csc(n1)CNC(=O)C[C@@H](/C=C/CCS)OC(=O)[C@H](Cc1ccccc1)NC2=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6760,ML00000607,CHEMBL92285,,C/C1=C/C[C@@H](c2ccc3sc(C)nc3c2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00000607_numbered.png,2026-03-19 06:57:46.255792
6761,ML00010101,,,CC(C)C[C@@H]1NC(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6762,ML00009416,,,C/C=C1\NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](C)C[C@@H](C)CCC)[C@@H](C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6763,ML00005524,,,C[C@@H]1OC(=O)[C@@H](c2cc(O)cc(O)c2)NC(=O)[C@H](c2cc(O)cc(O)c2)NC(=O)[C@@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]1NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Cl)[nH]1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6764,ML00001930,CHEMBL433337,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](c2ccc(O)cc2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6765,ML00006958,,,CC[C@@H]1C[C@@H](C)C(=O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H](OC)[C@@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006958_numbered.png,2026-03-19 06:57:46.326768
6766,ML00009850,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@@]2(OC)C[C@@H](O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009850_numbered.png,2026-03-19 06:57:46.373717
6767,ML00007827,,,CO[C@H]1CCCCCCCCC[C@@H](C)OC(=O)CCC1=O,standard_macrolactone,16.0,,,success,,3.0,"[3, 13, 14]",ring_size_16/standard/numbered/ML00007827_numbered.png,2026-03-19 06:57:46.402446
6768,ML00006378,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCCl)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006378_numbered.png,2026-03-19 06:57:46.455594
6769,ML00007680,,,C/C(=C\c1csc(C)n1)[C@@H]1CCCCCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)C(O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007680_numbered.png,2026-03-19 06:57:46.500456
6770,ML00005540,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005540_numbered.png,2026-03-19 06:57:46.554742
6771,ML00008220,,,C[C@H]1/C=C\CC/C=C\C=C/C/C=C\CCC(=O)O1,standard_macrolactone,16.0,,,success,,1.0,[3],ring_size_16/standard/numbered/ML00008220_numbered.png,2026-03-19 06:57:46.576914
6772,ML00001973,CHEMBL1531390,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@H](C)C/C(C)=C/C=C/[C@H](OC)[C@H]([C@@H](C)[C@@H](O)[C@H](C)[C@H]2C[C@@H](O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00001973_numbered.png,2026-03-19 06:57:46.622975
6773,ML00005937,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2cc(Cl)cc(Cl)c2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005937_numbered.png,2026-03-19 06:57:46.675782
6774,ML00006551,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2cccc(N(C)C)c2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006551_numbered.png,2026-03-19 06:57:46.730052
6775,ML00006594,,,CCC[C@@H]1OC(=O)[C@@H](C)[C@@H]2CC[C@H](C[C@@H](C)OC(=O)[C@@H](C)[C@H]3CC[C@H](O3)[C@H]1C)O2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6776,ML00003123,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=N\OC/C=C/c2cnc3ccccc3c2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003123_numbered.png,2026-03-19 06:57:46.790474
6777,ML00009174,,,COC1C(OCC2C(C)OC(=O)/C=C\C(C)C(OC3OC(C)CC(O)C3O)CCC(C)C(=O)/C=C\C3OC32)OC(C)C(O)C1OC,standard_macrolactone,16.0,,,success,,6.0,"[3, 4, 9, 10, 13, 14]",ring_size_16/standard/numbered/ML00009174_numbered.png,2026-03-19 06:57:46.831557
6778,ML00005256,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc(C(=O)c3ccccc3)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005256_numbered.png,2026-03-19 06:57:46.890618
6779,ML00001668,CHEMBL42743,TYLOSIN,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001668_numbered.png,2026-03-19 06:57:46.946154
6780,ML00009329,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(=O)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6781,ML00006432,,,CC[C@H]1OC(=O)C[C@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3C[C@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O[C@H]2CC[C@@H](N(C)C)[C@@H](C)O2)/C=C\C(C)=C/[C@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006432_numbered.png,2026-03-19 06:57:47.007622
6782,ML00009792,,,CC[C@@H]1OC(=O)/C=C\[C@H](C)[C@H](O[C@H]2O[C@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](C)C[C@@H](C)C(=O)/C=C\C=C/[C@@]1(O)CO[C@H]1O[C@H](C)[C@@H](O)[C@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009792_numbered.png,2026-03-19 06:57:47.057849
6783,ML00003421,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCO)C[C@@H](C)C(=O)/C=C\[C@@]2(C)O[C@@H]2[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003421_numbered.png,2026-03-19 06:57:47.112220
6784,ML00002672,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/[C@@H](O)[C@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](OC(=O)CC)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002672_numbered.png,2026-03-19 06:57:47.160918
6785,ML00007335,,,C/C1=C/[C@@H](C)C[C@@H](C)[C@@H](Cc2cnco2)OC(=O)/C(C)=C\[C@@H](C)C[C@@H](C)[C@@H](Cc2cnco2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6786,ML00007336,,,C/C1=C/[C@H](C)C[C@H](C)[C@H](Cc2cnco2)OC(=O)/C(C)=C\[C@@H](C)C[C@H](C)[C@H](Cc2cnco2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6787,ML00004661,,,CCOC(=O)/C=C/C[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](COC2OC(C)C(O)C(OC)C2OC)[C@@H](CC)OC(=O)C[C@@H](OC(=O)Cc2ccc([N+](=O)[O-])cc2)[C@H](C)[C@H]1OC1OC(C)C(O)C(N(C)C)C1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004661_numbered.png,2026-03-19 06:57:47.228686
6788,ML00003668,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=O)/C=C/[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003668_numbered.png,2026-03-19 06:57:47.286662
6789,ML00009364,,,COc1ccc(C[C@H]2NC(=O)/C=C\C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6790,ML00004446,,,CC[C@H]1OC(=O)C[C@@H](OC(C)=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004446_numbered.png,2026-03-19 06:57:47.352686
6791,ML00001280,CHEMBL3251867,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(=O)CC)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001280_numbered.png,2026-03-19 06:57:47.401675
6792,ML00003894,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C(C)=O)C2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003894_numbered.png,2026-03-19 06:57:47.455341
6793,ML00008236,,,CC1CC(=O)OC(C)C(O)/C=C/C(=O)OC(C)C(O)/C=C/C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6794,ML00000273,CHEMBL3934882,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(C3CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)ncc(F)c2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6795,ML00002719,,,CO[C@@H]1[C@@H](O)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](OC(C)=O)[C@H](C)C[C@H](CC=O)[C@H]1O[C@@H]1O[C@H](C)[C@H](O[C@@H]2C[C@@](C)(OC(C)=O)[C@@H](OC(C)=O)[C@@H](C)O2)[C@H](N(C)C)[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002719_numbered.png,2026-03-19 06:57:47.520204
6796,ML00001642,CHEMBL3244607,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](N(C)C)[C@@H](OC(=O)CCC(=O)O)[C@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)O[C@@H]2C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001642_numbered.png,2026-03-19 06:57:47.569225
6797,ML00008464,,,CC(=O)C[C@@H]1CCC(=O)/C=C\C(=O)O[C@H](CC(C)=O)CC[C@H](O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6798,ML00000123,CHEMBL379989,RHIZOXIN,CO[C@@H](/C(C)=C/C=C/C(C)=C/c1coc(C)n1)[C@@H](C)[C@@H]1C[C@H](O)[C@@]2(C)O[C@@H]2/C=C/[C@@H](C)[C@H]2C[C@H](CC(=O)O2)C[C@@H]2O[C@H]2C(=O)O1,standard_macrolactone,16.0,,,success,,4.0,"[3, 5, 6, 10]",ring_size_16/standard/numbered/ML00000123_numbered.png,2026-03-19 06:57:47.610240
6799,ML00009990,,,C/C(=C\c1csc(C)n1)[C@@H]1CC2OC(C)(C)OC2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00009990_numbered.png,2026-03-19 06:57:47.658587
6800,ML00002523,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)/C(C)=C/C)C(C)C)[C@@H](C)OC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(=O)O)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6801,ML00002334,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](C/C=C/C(C)=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002334_numbered.png,2026-03-19 06:57:47.721883
6802,ML00001391,CHEMBL2324838,,C=CCOC(=O)C[C@H]1CNC(=O)[C@@H](Cc2ccc(OC)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6803,ML00002187,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](C=O)C[C@@H](C)C(=N\OCCCc2ccc3ncccc3c2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002187_numbered.png,2026-03-19 06:57:47.785229
6804,ML00009137,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(=O)C#Cc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6805,ML00008692,,,CCCON=C1CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00008692_numbered.png,2026-03-19 06:57:47.816660
6806,ML00009830,,,CO[C@H]1[C@H](OC[C@H]2/C=C/CCC(=O)[C@@](C)(O)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@](O)([C@H](C)O)[C@H]3O)[C@@H](C)/C=C/C(=O)O[C@@H]2C)O[C@H](C)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009830_numbered.png,2026-03-19 06:57:47.867317
6807,ML00008182,,,CC1CCCCCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,1.0,[3],ring_size_16/standard/numbered/ML00008182_numbered.png,2026-03-19 06:57:47.892672
6808,ML00001254,CHEMBL122232,,CCCC1(CCC)CNC(=O)[C@@H](Cc2ccc(OC)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c2ccccc2)OC(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6809,ML00010313,,,CCC1CC(C)C(O)/C=C/C=C/CC(C)OC(=O)CC(O)C(OC)C1OC1OC(C)CC(O)(C(C)=O)C1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010313_numbered.png,2026-03-19 06:57:47.951629
6810,ML00007608,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C/C=C5/OCC[C@@]6(O[C@H]6C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)[C@@H]5O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6811,ML00002568,,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](NC3CCCCC3)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00002568_numbered.png,2026-03-19 06:57:48.015153
6812,ML00001304,CHEMBL3251858,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](N(C)C)[C@@H](OC(C)=O)[C@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)O[C@@H]2C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001304_numbered.png,2026-03-19 06:57:48.074019
6813,ML00003267,,,CCCC/C=C/C(=O)N[C@@H](Cc1cccc(F)c1)C(=O)N[C@@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H]2CC(C)CCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6814,ML00007190,,,C/C(=C\c1coc(C)n1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007190_numbered.png,2026-03-19 06:57:48.140907
6815,ML00002313,,,CO[C@H]1[C@@H](OC(C)=O)CC(=O)O[C@H](C)C[C@@H]2O[C@@H]2/C=C\[C@H](O)[C@@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@@H]2C[C@](C)(O)[C@H](OC(=O)CC(C)C)[C@@H](C)O2)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002313_numbered.png,2026-03-19 06:57:48.196921
6816,ML00010711,,,CCC(=O)O[C@H]1CC(=O)O[C@H](C)C/C=C\C=C/[C@H](C)[C@H](C)C[C@H](CC=O)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@@H](N(C)C)[C@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010711_numbered.png,2026-03-19 06:57:48.247106
6817,ML00006391,,,CO[C@@H]1[C@@H](OC(C)=O)CC(=O)O[C@@H](C)C/C=C\C=C/[C@H](O[C@@H]2C[C@@H](N(C)C)C[C@H](C)O2)[C@H](C)C[C@H](CC=O)[C@H]1O[C@@H]1C[C@H](C)[C@@H](O[C@@H]2C[C@](C)(O)[C@@H](O)[C@H](C)O2)[C@@H](N(C)C)[C@@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006391_numbered.png,2026-03-19 06:57:48.303148
6818,ML00001560,CHEMBL3251860,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](N(C)C)[C@@H](OC(=O)CC)[C@H](O[C@@H]3[C@@H](OC)[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)O[C@@H]2C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001560_numbered.png,2026-03-19 06:57:48.360612
6819,ML00005982,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN(C)CCCNC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005982_numbered.png,2026-03-19 06:57:48.422604
6820,ML00001518,CHEMBL403900,POLYDISCAMIDE B,CCC(C)(C)[C@H](NC(=O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(Br)cc1)NC(=O)[C@@H](C)NC=O)C(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CS(=O)(=O)O)C(=O)N[C@@H]1C(=O)N(C)[C@@H](CCC(N)=O)C(=O)N[C@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](CC(=O)O)C(=O)O[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6821,ML00009908,,,COC(=O)C[C@@H]1C/C=C\C(=O)O[C@H]([C@H](C)[C@@H](OC)/C(C)=C/C=C/C(C)=C/c2coc(C)n2)C[C@H](O)[C@@]2(C)O[C@@H]2/C=C\[C@@H](C)[C@H](O)C1,standard_macrolactone,16.0,,,success,,6.0,"[3, 5, 6, 10, 11, 13]",ring_size_16/standard/numbered/ML00009908_numbered.png,2026-03-19 06:57:48.490077
6822,ML00009251,,,CC(/C=C/C=C(\C)[C@H](O)[C@@H](C)[C@H]1C[C@H](O)[C@]2(C)O[C@H]2/C=C\[C@@H](C)[C@H](O)C[C@H](CC(=O)O)C/C=C\C(=O)O1)=C\c1coc(C)n1,standard_macrolactone,16.0,,,success,,6.0,"[3, 5, 6, 10, 11, 13]",ring_size_16/standard/numbered/ML00009251_numbered.png,2026-03-19 06:57:48.537406
6823,ML00009945,,,C/C(=C\c1cc(C)ccn1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00009945_numbered.png,2026-03-19 06:57:48.595291
6824,ML00010823,,,CC[C@H]1/C=C\[C@@H]([C@@H](O)C=C(C)C)OC(=O)/C(C)=C\[C@@H]2C(=O)NC3=CC(=O)c4c(cc(C)c(O)c4C(=O)CC1)[C@@]32O,standard_macrolactone,16.0,,,success,,5.0,"[3, 6, 9, 13, 16]",ring_size_16/standard/numbered/ML00010823_numbered.png,2026-03-19 06:57:48.639245
6825,ML00003919,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)C(CC=O)C[C@@H](C)[C@@H](O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003919_numbered.png,2026-03-19 06:57:48.694003
6826,ML00006112,,,CCOC(=O)c1ccc(OCC[C@H]2C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]2O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)cc1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006112_numbered.png,2026-03-19 06:57:48.760598
6827,ML00007011,,,O=C1CCCCCCCCCCC(=NOCc2c(F)cccc2Cl)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00007011_numbered.png,2026-03-19 06:57:48.788104
6828,ML00007825,,,CC1CCC(NS(C)(=O)=O)CCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/ML00007825_numbered.png,2026-03-19 06:57:48.820676
6829,ML00005709,,,C[C@@H]1NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)/C=C/C=C/C=C/C=C/C=C/C(=O)NC2=C(O)CCC2=O)COC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6830,ML00004527,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCCCCCc4ccccc4)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004527_numbered.png,2026-03-19 06:57:48.888675
6831,ML00002670,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](OC3[C@H](CC=O)C[C@@H](C)[C@@H](O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@@H](OC(=O)CC)[C@@H]3OC)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002670_numbered.png,2026-03-19 06:57:48.936531
6832,ML00009269,,,CO[C@@H]1[C@@H](OC[C@H]2[C@@H]3O[C@@H]3/C=C\C(=O)[C@](C)(O)CC[C@@H](O[C@H]3O[C@@H](C)C[C@@H](OC)[C@@H]3O)[C@H](C)/C=C\C(=O)O[C@@H]2C)O[C@@H](C)[C@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 10, 13, 14]",ring_size_16/standard/numbered/ML00009269_numbered.png,2026-03-19 06:57:48.981085
6833,ML00008402,,,CC(=O)CC1CCC(=O)CCC(=O)OC(CC(C)=O)CCC(=O)CCC(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6834,ML00006688,,,O=C1CCCCCCCCCC/C(=N/OC(=O)COc2ccc(Br)cc2Cl)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006688_numbered.png,2026-03-19 06:57:49.012778
6835,ML00009470,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCNCC(C)(C)CO)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009470_numbered.png,2026-03-19 06:57:49.071961
6836,ML00001939,CHEMBL406149,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](n2cccc2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6837,ML00002298,,,CO[C@@H]1[C@@H](OC2OC(C)C(OC3CC(C)(O)C(OC(=O)CC(C)C)C(C)O3)C(N(C)C)C2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002298_numbered.png,2026-03-19 06:57:49.133143
6838,ML00001988,CHEMBL313330,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)C3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6839,ML00007523,,,CC1CCC(=NOC(=O)C(C)Oc2ccc(Cl)cc2)CCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/ML00007523_numbered.png,2026-03-19 06:57:49.172074
6840,ML00010964,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@@H]2O)[C@@H](CC(=O)O)C[C@@H](C)C(=O)/C=C\[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010964_numbered.png,2026-03-19 06:57:49.232402
6841,ML00009435,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC(=O)Nc1ccccc1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009435_numbered.png,2026-03-19 06:57:49.293145
6842,ML00003720,,,CCC[C@H]1C[C@@H]2CC[C@@H](O2)[C@H](CC)C(=O)O[C@@H]([C@H](CC)[C@H]2CC[C@@H](C[C@@H](CCC)N(C)C)O2)[C@H](C)[C@@H]2CC[C@@H](O2)[C@@H](CC)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6843,ML00010649,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(Br)C#Cc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6844,ML00008747,,,Cc1nc2c([nH]1)CCCCCCCCC[C@@H](C)OC(=O)/C=C/2,standard_macrolactone,16.0,,,success,,1.0,[3],ring_size_16/standard/numbered/ML00008747_numbered.png,2026-03-19 06:57:49.334878
6845,ML00002068,CHEMBL251118,,C[C@@]1(N)Cc2cccc(c2)CC[C@H](c2ccccc2)NC(=O)c2cc(Br)cc(c2)COC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6846,ML00001136,CHEMBL350017,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)C[C@@H](C)NC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6847,ML00000288,CHEMBL3808853,,CC1COC(=O)Nc2cccc(c2)CNC(=O)C(Nc2ccc3c(N)nccc3c2)c2ccc1cc2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6848,ML00003266,,,CCCC/C=C/C(=O)N[C@@H](Cc1cccc(F)c1)C(=O)N[C@@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@@H]2CC(C)CCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6849,ML00008436,,,C[C@@H]1CCCCCCCCC[C@H](OC(=O)CCC(=O)O)C(=O)/C=C\C(=O)O1,standard_macrolactone,16.0,,,success,,3.0,"[3, 13, 14]",ring_size_16/standard/numbered/ML00008436_numbered.png,2026-03-19 06:57:49.398299
6850,ML00008852,,,COC(/C(C)=C/C=C/C(C)=C/c1coc(C)n1)C(C)C1CC(O)C2(C)OC2C=CC(C)C2CC(CC(=O)O2)CC2OC2C(=O)O1,standard_macrolactone,16.0,,,success,,4.0,"[3, 5, 6, 10]",ring_size_16/standard/numbered/ML00008852_numbered.png,2026-03-19 06:57:49.435765
6851,ML00009021,,,CO[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)/C=C\C(=O)O[C@H](C)[C@@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)/C=C\CCC(=O)[C@H](C)C[C@@H]2C)[C@@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009021_numbered.png,2026-03-19 06:57:49.487633
6852,ML00001199,CHEMBL3939509,,CCS(=O)(=O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1ccc3c(N)ncc(F)c3c1)c1ccc(c(C)c1)[C@@H](C)COC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6853,ML00009524,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCNC2C(O)CCCC2O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009524_numbered.png,2026-03-19 06:57:49.548577
6854,ML00009636,,,CC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@@H]2O)[C@H](C)C[C@@H](C)C(=O)/C=C\[C@H]2O[C@@H]2[C@@H]1CO[C@@H]1O[C@H](C)[C@H](O)[C@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009636_numbered.png,2026-03-19 06:57:49.594460
6855,ML00010963,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010963_numbered.png,2026-03-19 06:57:49.645161
6856,ML00002132,CHEMBL4077853,,CCS(=O)(=O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1ccc3cc[nH]c(=O)c3c1)c1ccc(cc1)CCOC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6857,ML00008405,,,CC[C@@H]1OC(=O)CCC/C=C\C/C=C\C/C=C\[C@H]2[C@H]1C[C@@H](Cl)[C@@H]2O,standard_macrolactone,16.0,,,success,,1.0,[3],ring_size_16/standard/numbered/ML00008405_numbered.png,2026-03-19 06:57:49.674118
6858,ML00000718,CHEMBL3349528,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6859,ML00009319,,,COc1ccc(C[C@H]2NC(=O)/C=C\C[C@@H](C/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6860,ML00002995,,,C=C1Oc2cc(OC)cc(C(=O)O[C@H]3COC(=O)C[C@H](N)c4cc(O)c(c(Cl)c4)O[C@@H]4C#C/C=C/3C#CC3=CC=C[C@@]34O[C@@H]3OC(C)(C)[C@@H](N(C)C)[C@@H](O)[C@H]3O)c2NC1=O,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6861,ML00004877,,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](C(=O)OCNC(=O)OCC3c4ccccc4-c4ccccc43)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00004877_numbered.png,2026-03-19 06:57:49.742718
6862,ML00003287,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=N/OCCOc2ccccc2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003287_numbered.png,2026-03-19 06:57:49.804917
6863,ML00002922,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O[C@@H]2CC[C@H](N(C)C)[C@@H](C)O2)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002922_numbered.png,2026-03-19 06:57:49.861166
6864,ML00008189,,,C[C@H]1CCC(=O)/C=C\C(=O)O[C@H](C)CCC(=O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6865,ML00001154,CHEMBL328224,,C/C1=C/C[C@@H](c2ccc3cccnc3c2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00001154_numbered.png,2026-03-19 06:57:49.923951
6866,ML00009064,,,CC[C@@H]1OC(=O)/C=C\[C@H](C)[C@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@H](C)C(=O)/C=C\C=C/[C@@H]1CO[C@@H]1O[C@@H](C)[C@H](O)[C@H](O)[C@@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009064_numbered.png,2026-03-19 06:57:49.977017
6867,ML00001098,CHEMBL3956442,,CC[C@@H](C(=O)O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1ccc3c(N)ncc(F)c3c1)c1ccc(c(C)c1)[C@@H](C)COC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6868,ML00001985,CHEMBL124364,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccccc3)OC(=O)[C@H](CC(C)C)NC(=O)C3(CC3)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6869,ML00009041,,,CO[C@@H]1/C=C\C=C(\C)C[C@H](C)[C@H](O)[C@H](C)/C=C(C)\C=C(\C)C(=O)O[C@H]1/C(C)=C/[C@H](C)C1=CC=C(C)[C@H](C(C)C)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009041_numbered.png,2026-03-19 06:57:50.047525
6870,ML00007032,,,O=C1CCCCCCCCCCC2(CCCO1)N=N/C(=N/c1ccc(Br)cc1)S2,standard_macrolactone,16.0,,,success,,0.0,[],ring_size_16/standard/numbered/ML00007032_numbered.png,2026-03-19 06:57:50.070079
6871,ML00000097,CHEMBL3917434,,CCN(CC)C(=O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1ccc3c(N)nccc3c1)c1ccc(c(C)c1)[C@@H](C)COC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6872,ML00002515,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccc(CN4CCNCC4)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6873,ML00000270,CHEMBL3967204,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(C3(c4nnn[nH]4)CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)ncc(F)c2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6874,ML00001418,CHEMBL327295,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccc(C)c(C)c3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6875,ML00010468,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@]5([C@H](C)O)OCC[C@]6(O[C@H]6C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)[C@H]5O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6876,ML00001596,CHEMBL3251868,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(=O)CCC)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001596_numbered.png,2026-03-19 06:57:50.163617
6877,ML00009787,,,CC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)CC[C@@H](C)C(=O)/C=C\[C@H]2O[C@@H]2[C@]1(O)CO[C@H]1O[C@@H](C)[C@H](O)[C@@H](OC)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 4, 9, 10, 13, 14]",ring_size_16/standard/numbered/ML00009787_numbered.png,2026-03-19 06:57:50.214560
6878,ML00010102,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@@H](C(C)C)NC(=O)C[C@H](/C=C/c2ccccc2)OC(=O)[C@@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6879,ML00005101,,,C/C=C(\NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCN1C(=O)/C(=C/C)NC(=O)CC(O)CCCCC)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCO)C(=O)N[C@H](CCN)C(=O)N[C@@H](CCCCN)C(=O)O[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6880,ML00005104,,,C/C=C(\NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCN1C(=O)/C(=C/C)NC(=O)CC(O)CCCCC)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCO)C(=O)N[C@H](CCN)C(=O)N[C@@H](CCCCN)C(=O)O[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6881,ML00003892,,,CCC(=O)O[C@H]1[C@@H](C)O[C@@H](O[C@H]2[C@@H](N(C)C)C[C@H](O[C@@H]3[C@H](CC=O)C[C@H](C)[C@H](O)/C=C\[C@@H]4O[C@H]4C[C@@H](C)OC(=O)C[C@H](OC(C)=O)[C@@H]3OC)O[C@@H]2C)C[C@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003892_numbered.png,2026-03-19 06:57:50.309224
6882,ML00002522,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)C=C(C)C)C(C)C)[C@@H](C)OC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(=O)O)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6883,ML00001646,CHEMBL3251862,,CCC(=O)O[C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](OC(C)=O)[C@H](OC)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@H]1C,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001646_numbered.png,2026-03-19 06:57:50.364229
6884,ML00010765,,,CCCCCCCCCCCC[C@@H]1CCCCCCCCC(=O)OC[C@H]2O[C@@H](O1)[C@H](OC(C)=O)[C@@H](O)[C@@H]2O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6885,ML00005482,,,CCOC(=O)NN(CC[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](CO[C@@H]2O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]2OC)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]1O)C(=O)OCC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005482_numbered.png,2026-03-19 06:57:50.422878
6886,ML00009055,,,CO/C1=C\C(C)=C\[C@@H](C)C(=O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)CC(=O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009055_numbered.png,2026-03-19 06:57:50.469045
6887,ML00006812,,,CC(Oc1ccc(Cl)cc1Cl)C(=O)ON=C1CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006812_numbered.png,2026-03-19 06:57:50.491490
6888,ML00009894,,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)/C=C(\C)C2=C[C@@H](OC)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009894_numbered.png,2026-03-19 06:57:50.536789
6889,ML00001122,CHEMBL3977297,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1cc(F)c(O[C@@H](C)CO)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6890,ML00009812,,,COCCOCCC(=O)NCCCC[C@H]1C(=O)C(C)(C)[C@@H](O)CC(=O)O[C@H](/C(C)=C/c2csc(C)n2)C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00009812_numbered.png,2026-03-19 06:57:50.591166
6891,ML00007354,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@H](O)[C@@](C)(O)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)C(O)CC(=O)O1,standard_macrolactone,16.0,,,success,,11.0,"[3, 5, 6, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007354_numbered.png,2026-03-19 06:57:50.644573
6892,ML00009074,,,CO[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)/C=C/C(=O)O[C@H](C)[C@@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)[C@@H]3O[C@H]3/C=C/C(=O)[C@@](C)(O)C[C@@H]2C)[C@@H]1O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009074_numbered.png,2026-03-19 06:57:50.692144
6893,ML00000621,CHEMBL2323287,,CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)-c2nnnn2CC(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6894,ML00009916,,,CO[C@@H]1C[C@H](OC(N)=O)[C@@H]2C=C[C@@H]3/C=C(C)\C=C/[C@@H](C)[C@H]([C@H](C)[C@H](O)[C@@H](C)NC(C)=O)OC(=O)/C=C\C=C(C)/C=C\[C@]3(C)[C@@H]2C1,standard_macrolactone,16.0,,,success,,5.0,"[3, 4, 7, 10, 13]",ring_size_16/standard/numbered/ML00009916_numbered.png,2026-03-19 06:57:50.733258
6895,ML00005724,,,C/C=C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H]2OC)C[C@@H](OC(=O)/C=C/C(=O)NC2=C(O)CCC2=O)[C@@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00005724_numbered.png,2026-03-19 06:57:50.780425
6896,ML00001950,CHEMBL61164,,CC1C/C=C\CCCCCCCCCOC(=O)N1CC(O)C(Cc1ccccc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@@H]12,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6897,ML00007688,,,CCC[C@H]1CCCC(=O)N[C@@H](CO)CCC[C@H](C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6898,ML00002766,,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(OC)C[C@@H](C(=O)Oc3ccccc3)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00002766_numbered.png,2026-03-19 06:57:50.840613
6899,ML00005486,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCO)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005486_numbered.png,2026-03-19 06:57:50.894443
6900,ML00006864,,,O=C1CCCCCCCCCCC(NS(=O)(=O)Cc2ccccc2)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006864_numbered.png,2026-03-19 06:57:50.917607
6901,ML00010922,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/C(=O)[C@H](C)C[C@H](CC=O)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](N(C)C)[C@@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010922_numbered.png,2026-03-19 06:57:50.963172
6902,ML00003686,,,CC[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](C)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003686_numbered.png,2026-03-19 06:57:51.018948
6903,ML00009071,,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)CC(=O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009071_numbered.png,2026-03-19 06:57:51.069190
6904,ML00001016,CHEMBL3426551,,CO[C@H]1/C=C(/C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O[C@@H]1/C(C)=C/c1csc(C)n1,standard_macrolactone,16.0,,,success,,10.0,"[3, 4, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00001016_numbered.png,2026-03-19 06:57:51.125412
6905,ML00006664,,,O=C1CCCCCCCCCCC(=NOC(=O)COc2ccc(Cl)cc2Cl)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006664_numbered.png,2026-03-19 06:57:51.150671
6906,ML00006534,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2OC(C)=O)[C@@H](CCOc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006534_numbered.png,2026-03-19 06:57:51.210223
6907,ML00010325,,,C[C@H]1C[C@H](C)[C@H](O[C@@H]2O[C@H](C)C[C@](O)([C@H](C)O)[C@H]2O)[C@@H](C)/C=C\C(=O)O[C@H](C)[C@@H](C)/C=C\C=C/C1=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00010325_numbered.png,2026-03-19 06:57:51.260580
6908,ML00001329,CHEMBL100279,,COc1ccc(/C=C/[C@@H](C)[C@@H]2C/C=C/C(=O)N[C@H](Cc3ccc(OC)c(Cl)c3)C(=O)NCC(C)(C)C(=O)O[C@@H](CC(C)C)C(=O)O2)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6909,ML00008137,,,C[C@H]1CC[C@@H](O)/C=C\C(=O)O[C@@H](C)CC[C@@H](O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6910,ML00005547,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@H](CC=O)C[C@@H](C)[C@@H](OC(C)=O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@@H](OC(=O)CC)[C@@H]3OC)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005547_numbered.png,2026-03-19 06:57:51.330180
6911,ML00003789,,,COC(=O)[C@H]1[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC)[C@H](C)[C@@H](C(C)C)O2)OC(=O)/C(OC)=C/C(C)=C/[C@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00003789_numbered.png,2026-03-19 06:57:51.385368
6912,ML00000131,CHEMBL3628320,,CCCCCCCCSSCC/C=C/[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N[C@H](C)C(=O)N[C@H](C(C)C)C(=O)NCC(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6913,ML00010164,,,CC[C@H]1C[C@@H](C)C(=O)/C=C\C(C)=C/[C@H](C)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@H]1O[C@H](C)[C@H](O)[C@H](O)[C@@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010164_numbered.png,2026-03-19 06:57:51.450611
6914,ML00009414,,,C/C=C1\NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](C)C[C@@H](C)CCC)[C@H](C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6915,ML00001902,CHEMBL394224,,CN(c1cc2cc(n1)N(CC1CC1)CCCCc1cccc(c1)C[C@@](C)(N)C(=O)OC2)S(C)(=O)=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6916,ML00000650,CHEMBL3628313,,CC(C)[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)NCc1ccc(Br)cc1CC(=O)O2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6917,ML00009988,,,C=C1C[C@H]2CCC[C@H](O)C[C@@H](c3coc(/C=C(/C)[C@@H](C)OC)n3)OC(=O)[C@@H](C)C[C@H](C)[C@@H](OP(=O)(O)O)C[C@@H](C1)O2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6918,ML00000875,CHEMBL3581385,,CC(=O)O[C@@H](CCCC[C@@H](O)CC(=O)N[C@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)N[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C)C(C)C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6919,ML00001933,CHEMBL327294,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c3csc(C)n3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6920,ML00008832,,,COc1ccc(C[C@@H]2NC(=O)/C=C\C[C@@H]([C@H](C)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6921,ML00009849,,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009849_numbered.png,2026-03-19 06:57:51.564828
6922,ML00003683,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@H](O)[C@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@@H](CCO)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003683_numbered.png,2026-03-19 06:57:51.629376
6923,ML00000201,CHEMBL3984725,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(C3(C(=O)O)CCCC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)ncc(F)c2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6924,ML00003670,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=O)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003670_numbered.png,2026-03-19 06:57:51.691376
6925,ML00009422,,,CO[C@@H]1[C@@H](OC[C@@H]2/C=C\C=C/C(=O)[C@@H](C)C[C@H](C)[C@@H](O[C@H]3O[C@H](C)C[C@]4(OC(=O)O[C@@H]4C)[C@@H]3O)[C@H](C)/C=C\C(=O)O[C@H]2C)O[C@@H](C)[C@H](O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009422_numbered.png,2026-03-19 06:57:51.738244
6926,ML00002716,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCCc2ccccc2)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002716_numbered.png,2026-03-19 06:57:51.791456
6927,ML00003921,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003921_numbered.png,2026-03-19 06:57:51.837998
6928,ML00002297,,,CO[C@@H]1[C@@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@](C)(O)[C@@H](OC(=O)CC(C)C)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\C=C/C[C@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002297_numbered.png,2026-03-19 06:57:51.884327
6929,ML00009073,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@H](OC)[C@H]([C@@H](C)[C@@H](O)[C@H](C)C(=O)/C=C/[C@H](C)[C@H](O)C(C)C)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009073_numbered.png,2026-03-19 06:57:51.930895
6930,ML00008956,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CCCC2)C[C@@H](C)C(=O)/C=C/[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00008956_numbered.png,2026-03-19 06:57:51.982820
6931,ML00002494,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccc(OC(=O)C(C)(C)CN)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6932,ML00002535,,,CC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](C)C[C@@H](C)C(=O)C[C@@H](SC[C@@H](NC(C)=O)C(=O)O)[C@H]2O[C@@H]2[C@]1(O)CO[C@@H]1O[C@H](C)[C@@H](O)[C@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 4, 7, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00002535_numbered.png,2026-03-19 06:57:52.064752
6933,ML00001230,CHEMBL349357,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)C[C@@H](Cc3ccccc3)NC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6934,ML00001558,CHEMBL3244600,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](OC(=O)CCl)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001558_numbered.png,2026-03-19 06:57:52.127498
6935,ML00010710,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COCOC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010710_numbered.png,2026-03-19 06:57:52.187263
6936,ML00006940,,,CC[C@H]1C[C@@H](C)[C@H](O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@H](O)[C@@H](OC)[C@@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006940_numbered.png,2026-03-19 06:57:52.236874
6937,ML00010521,,,CC(C)C[C@@H]1NC(=O)[C@@H](CC(C)C)OC(=O)CCN(C)C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6938,ML00010933,,,CCC1OC(=O)CC(O)C(C)C(OC2OC(C)C(O)C(N(C)C)C2O)C(CC=O)CC(C)C(=O)/C=C/C2(C)OC2C1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010933_numbered.png,2026-03-19 06:57:52.303527
6939,ML00006921,,,O=C1CCCCCCCCCCC(NS(=O)(=O)c2ccc(F)cc2)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006921_numbered.png,2026-03-19 06:57:52.330246
6940,ML00000312,CHEMBL362592,,CC(C)C[C@H](NC(=O)[C@@H]1CC(=O)NCCCCCCOC(=O)N[C@@H](C(C)C)C(=O)N1)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6941,ML00000261,CHEMBL2269362,"(5S,8R,13S,16R)-(-)-PYRENOPHOROL",C[C@@H]1CC[C@H](O)/C=C/C(=O)O[C@H](C)CC[C@H](O)/C=C/C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6942,ML00008183,,,C[C@@H]1CCCCCCCCCCCCC(=O)OC1,standard_macrolactone,16.0,,,success,,1.0,[4],ring_size_16/standard/numbered/ML00008183_numbered.png,2026-03-19 06:57:52.369643
6943,ML00009517,,,CCC[C@H]1OC(=O)[C@H](C)[C@H]2CC[C@H](O2)[C@H](C)[C@@H]([C@@H](CC)[C@@H]2CC[C@H](C[C@@H](CCC)N(C)C)O2)OC(=O)[C@@H](C)[C@H]2CC[C@H](O2)[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6944,ML00000294,CHEMBL165020,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccc(C(=O)c4ccccc4)cc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6945,ML00001922,CHEMBL251310,,C[C@@]1(N)Cc2ccc(F)c(c2)CC[C@H](c2ccc(F)cc2)NC(=O)c2cc(cc(-c3ccccc3C#N)c2)COC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6946,ML00009022,,,C/C(=C\[C@H](C)[C@H](O)[C@H](C)CO)[C@H]1O[C@]1(C)[C@@H]1OC(=O)[C@H](C)[C@@]2(O)O[C@@H](/C=C\C[C@H](O)/C=C\CC[C@@H]1C)[C@H](CC(C)C)[C@@H](O)[C@@H]2O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6947,ML00001152,CHEMBL3915633,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1cc(F)c(O[C@H](C)CO)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6948,ML00000281,CHEMBL3809472,,Nc1nccc2cc(NC3C(=O)NCc4cccc(c4)NC(=O)OCCc4ccc3cc4)ccc12,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6949,ML00000847,CHEMBL2324837,,C=CCOC(=O)C[C@@H]1CNC(=O)[C@@H](Cc2ccc(OC)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6950,ML00002752,,,CO[C@H]1[C@H](O)CO[C@@H](O[C@H]2C[C@H]3C[C@@H]([C@H]4C[C@@H]4C)OC(=O)C[C@@H]4O[C@@H](C[C@H](O[C@@H]5OC[C@@H](OC)[C@H](OC)[C@H]5OC)[C@H]4C)C[C@@H]([C@H]4C[C@@H]4C)OC(=O)C[C@H](O3)[C@@H]2C)[C@@H]1OC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6951,ML00007835,,,CO[C@H]1CCCCCCCCC[C@@H](C)OC(=O)C2OC2C1=O,standard_macrolactone,16.0,,,success,,3.0,"[3, 13, 14]",ring_size_16/standard/numbered/ML00007835_numbered.png,2026-03-19 06:57:52.464726
6952,ML00009793,,,CC[C@@H]1OC(=O)/C=C\C[C@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](C)C[C@H](C)C(=O)/C=C\C=C/[C@]1(O)CO[C@H]1O[C@@H](C)[C@H](O)[C@@H](OC)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 4, 9, 10, 12, 13]",ring_size_16/standard/numbered/ML00009793_numbered.png,2026-03-19 06:57:52.516025
6953,ML00009542,,,CCCCC[C@H](C[C@H]1CC[C@@H]([C@H](C)[C@@H]2OC(=O)[C@@H](C)[C@H]3CC[C@@H](C[C@@H](CCC)OC(=O)[C@@H](C)[C@H]4CC[C@H](O4)[C@H]2C)O3)O1)N(C)C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6954,ML00001557,CHEMBL3244601,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](OC(=O)C(Cl)Cl)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001557_numbered.png,2026-03-19 06:57:52.577527
6955,ML00002266,,,CCCC/C=C/C(=O)N[C@@H](Cc1csc2ccccc12)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](CC)NC(=O)[C@@H]2CCCCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6956,ML00010434,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@]56OCC[C@@]7(O[C@H]7C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)[C@H]5O[C@H](O)[C@H]6O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6957,ML00009421,,,CO[C@H]1[C@H](OC[C@H]2/C=C\C=C/C(=O)[C@H](C)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@@]4(OC(=O)O[C@H]4C)[C@H]3O)[C@@H](C)/C=C\C(=O)O[C@H]2C)O[C@H](C)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009421_numbered.png,2026-03-19 06:57:52.647455
6958,ML00009841,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CCCCC2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009841_numbered.png,2026-03-19 06:57:52.707960
6959,ML00006844,,,COC(=O)c1ccccc1S(=O)(=O)NC1CCCCCCCCCCC(=O)OC(C)CC1,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/ML00006844_numbered.png,2026-03-19 06:57:52.739676
6960,ML00000178,CHEMBL435745,,C/C(=C\c1ccc(C)cn1)[C@@H]1C[C@@H]2C[C@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)CCC(=O)O1,standard_macrolactone,16.0,,,success,,7.0,"[3, 10, 11, 12, 13, 14, 14]",ring_size_16/standard/numbered/ML00000178_numbered.png,2026-03-19 06:57:52.787540
6961,ML00007891,,,CC(=O)O[C@@H]1/C=C\C(=O)O[C@H](C)CCC(=O)/C=C\C(=O)O[C@H](C)CC1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6962,ML00002840,,,CCCC/C=C/C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](CC)NC(=O)[C@@H]2CCCCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6963,ML00005153,,,CCC(C)(C)[C@H](NC(=O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)C(NC(=O)[C@@H](C)NC=O)C(O)c1ccc(Br)cc1)C(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CS(=O)(=O)O)C(=O)N[C@@H]1C(=O)N(C)[C@@H](CCC(N)=O)C(=O)N[C@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](CC(=O)O)C(=O)O[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6964,ML00003399,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCCl)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003399_numbered.png,2026-03-19 06:57:52.884518
6965,ML00008851,,,CO[C@@H](/C(C)=C/C=C/C(C)=C/c1coc(C)n1)[C@@H](C)[C@@H]1C[C@H](O)[C@@]2(C)O[C@@H]2/C=C\[C@@H](C)[C@H]2C[C@H](CC(=O)O2)C[C@@H]2O[C@H]2C(=O)O1,standard_macrolactone,16.0,,,success,,4.0,"[3, 5, 6, 10]",ring_size_16/standard/numbered/ML00008851_numbered.png,2026-03-19 06:57:52.924013
6966,ML00001179,CHEMBL3908500,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1cc(F)c(S(=O)(=O)C(C)C)c(c1)CN(C)C(=O)[C@@H]2Nc1cc(F)c2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6967,ML00000305,CHEMBL2106399,KITASAMYCIN,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00000305_numbered.png,2026-03-19 06:57:52.980783
6968,ML00010623,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](C(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6969,ML00009390,,,C/C=C/C=C/C=C\C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6970,ML00000407,CHEMBL3410865,,COc1ccc(C[C@@H]2NC(=O)/C=C/C[C@@H](c3ccccc3[N+](=O)[O-])OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6971,ML00009859,,,C/C=C/C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6972,ML00006939,,,CC[C@H]1C[C@@H](C)[C@@H](O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@H](OC)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006939_numbered.png,2026-03-19 06:57:53.054188
6973,ML00006805,,,Cc1cc(Cl)ccc1OCC(=O)ON=C1CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006805_numbered.png,2026-03-19 06:57:53.080544
6974,ML00001990,CHEMBL313031,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccc(O)c(O)c2)NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6975,ML00009944,,,C/C(=C\c1ncccc1C)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00009944_numbered.png,2026-03-19 06:57:53.144648
6976,ML00007068,,,CC1CCC(NS(=O)(=O)c2cc(Cl)ccc2Cl)CCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/ML00007068_numbered.png,2026-03-19 06:57:53.174923
6977,ML00004080,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCO)C[C@@H](C)C(=O)/C=C\[C@H](C)C[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004080_numbered.png,2026-03-19 06:57:53.233330
6978,ML00006392,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006392_numbered.png,2026-03-19 06:57:53.288587
6979,ML00002331,,,CCCC(=O)O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(=O)CC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002331_numbered.png,2026-03-19 06:57:53.340891
6980,ML00008178,,,CS(=O)(=O)NC1CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00008178_numbered.png,2026-03-19 06:57:53.366189
6981,ML00000126,CHEMBL3628319,,CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N[C@H](C)C(=O)N[C@H](C(C)C)C(=O)NCC(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6982,ML00004804,,,CCOC(=O)NN(CC[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](CO[C@@H]2O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]2OC)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](N(C)C)[C@H]1O)C(=O)OCC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004804_numbered.png,2026-03-19 06:57:53.434735
6983,ML00007333,,,C/C1=C/[C@@H](C)C[C@@H](C)[C@H](Cc2cnco2)OC(=O)/C(C)=C\[C@@H](C)C[C@@H](C)[C@H](Cc2cnco2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6984,ML00007065,,,C/C1=C/C(=O)O[C@@H](C[C@@H](O)[C@@H]2CSC(=O)N2)C[C@H](O)CC[C@H](C)/C=C\C=C/CC1,standard_macrolactone,16.0,,,success,,4.0,"[3, 5, 8, 15]",ring_size_16/standard/numbered/ML00007065_numbered.png,2026-03-19 06:57:53.479220
6985,ML00002009,CHEMBL86849,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccc(O)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H]2O[C@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6986,ML00002811,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](CCOc2ccccc2)C[C@@H](C)C(=O)/C=C/C=C/[C@@H]1COC1OC(C)C=CC1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002811_numbered.png,2026-03-19 06:57:53.540278
6987,ML00009616,,,CO[C@H]1/C=C/C=C(\C)C[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C=C(\C)C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(OC)C[C@@H](OC)[C@H](C)[C@@H](C(C)C)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009616_numbered.png,2026-03-19 06:57:53.589428
6988,ML00002292,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C2OC2C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002292_numbered.png,2026-03-19 06:57:53.637467
6989,ML00002135,,,CO/C1=C\C(C)=C\[C@@H](C)C(=O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](C(=O)Oc3ccccc3)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00002135_numbered.png,2026-03-19 06:57:53.686157
6990,ML00011019,,,C/C(=C\c1csc(C)n1)[C@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H]2O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00011019_numbered.png,2026-03-19 06:57:53.734356
6991,ML00009076,,,CO/C1=C/C(C)=C\[C@@H](C)[C@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@@H](C)C(=O)/C=C/[C@H](C)[C@H](O)C(C)C)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009076_numbered.png,2026-03-19 06:57:53.780958
6992,ML00001430,CHEMBL3244598,,CCC(=O)O[C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@H](OC)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@H]1C,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001430_numbered.png,2026-03-19 06:57:53.827465
6993,ML00010954,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010954_numbered.png,2026-03-19 06:57:53.879102
6994,ML00000177,CHEMBL372255,,CSc1nc(/C=C(\C)[C@@H]2C/C=C\CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O2)cs1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00000177_numbered.png,2026-03-19 06:57:53.924566
6995,ML00000981,CHEMBL3903215,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1cc(F)c(OCCN3CCCC3=O)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
6996,ML00009318,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c3ccccc3)OC(=O)[C@@H](CC(C)C)OC(=O)CCNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6997,ML00010411,,,CC(=O)[C@@]12CC/C=C/C(=O)O[C@@H]3C[C@H]4O[C@@H]5C=C(C)CC[C@]5(COC(=O)/C=C(\CCO1)[C@H]2O)[C@]3(C)[C@]41CO1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6998,ML00010642,,,CC(C)C[C@@H]1OC(=O)CCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6999,ML00002726,,,CCC(=O)O[C@H]1CC(=O)O[C@H](C)C[C@@H]2O[C@@H]2/C=C\[C@H](O)[C@@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@H](C)[C@@H](O[C@H]3C[C@](C)(O)[C@@H](OC(=O)CC(C)C)[C@@H](C)O3)[C@@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002726_numbered.png,2026-03-19 06:57:53.999380
7000,ML00003059,,,CCCO[C@@H]1[C@@H](N(C)C)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@H](CC)[C@@H](CO[C@@H]2O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]2OC)/C=C(C)/C=C/C(=O)[C@H](C)C[C@@H]1CCCl,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003059_numbered.png,2026-03-19 06:57:54.051923
7001,ML00008955,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CCCC2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00008955_numbered.png,2026-03-19 06:57:54.103094
7002,ML00004647,,,CCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](C/C=C/c4cccnc4)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(=O)CC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7003,ML00009243,,,CC(=O)N(CCOc1ccccc1)C1CC(=O)[C@@H](OC(=O)CCC(=O)OC(C)(C)C)CCCCCCCCC[C@@H](C)OC1=O,standard_macrolactone,16.0,,,success,,4.0,"[3, 13, 14, 16]",ring_size_16/standard/numbered/ML00009243_numbered.png,2026-03-19 06:57:54.144704
7004,ML00005475,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)C)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005475_numbered.png,2026-03-19 06:57:54.199085
7005,ML00004144,,,CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](C)NC(=O)[C@@H]2C[C@@H](C)CCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7006,ML00005887,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@]2(O)C[C@@H](OC(=O)/C=C/C(=O)NC3=C(O)CCC3=O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00005887_numbered.png,2026-03-19 06:57:54.254427
7007,ML00001092,CHEMBL3287006,,CC(C)[C@@H]1NC(=O)c2csc(n2)-c2csc(n2)CNC(=O)C[C@@H](/C=C/CCS)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7008,ML00002907,,,NC(=O)CNC(=O)C1CCCN1C(=O)C1CCCCNOC(=O)CC[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)NC(Cc2c[nH]c3ccccc23)C(=O)N1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7009,ML00006836,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@H]2O[C@@H](OC)C[C@H]2C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 6, 9, 10, 14, 15]",ring_size_16/standard/numbered/ML00006836_numbered.png,2026-03-19 06:57:54.309724
7010,ML00009575,,,CCC[C@H]1C[C@@H]2CC[C@@H](O2)[C@H](CC)C(=O)O[C@@H]([C@H](C)[C@H]2CC[C@@H](C[C@@H](CCC)N(C)C)O2)[C@H](C)[C@@H]2CC[C@@H](O2)[C@@H](CC)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7011,ML00003391,,,CCC1OC(=O)CC(O)C(C)C(OC2CC(N(C)C)C(O)C(C)O2)C(CC=O)CC(C)C(=O)/C=C\C2(C)OC2C1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003391_numbered.png,2026-03-19 06:57:54.368429
7012,ML00006891,,,CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCN)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7013,ML00009212,,,CC[C@H]1OC(=O)C[C@@H](OC(C)=O)[C@@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C\[C@@]2(C)O[C@H]2[C@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009212_numbered.png,2026-03-19 06:57:54.430823
7014,ML00005412,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)C[C@H](O)[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)OC[C@H](O)[C@@H]2NC(=O)[C@H](C)N(C)C(=O)CN(C)C(=O)[C@@H]3CCCN3C(=O)[C@@H](C(C)C)NC2=O)c(N)c1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7015,ML00007672,,,C/C(=C\c1csc(C)n1)[C@@H]1CC(O)C(O)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,10.0,"[3, 5, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007672_numbered.png,2026-03-19 06:57:54.494915
7016,ML00009605,,,CO[C@H]1[C@H](O[C@H]2[C@@H](C)/C=C\C(=O)O[C@@H](C)[C@H](CO[C@@H]3O[C@H](C)C[C@@]4(OC(=O)O[C@H]4C)[C@H]3O)[C@H]3O[C@@H]3CCC(=O)[C@H](C)C[C@@H]2C)O[C@H](C)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009605_numbered.png,2026-03-19 06:57:54.541667
7017,ML00010934,,,CC(=O)O[C@@H]1/C2=C\C(=O)OC[C@]34CCC(C)=C[C@H]3O[C@@H]3C[C@@H](OC(=O)/C=C\C=C/[C@]1([C@H](C)O)OCC2)[C@@]4(C)[C@]31CO1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7018,ML00009991,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2OC(C)(C)O[C@@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)C(O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00009991_numbered.png,2026-03-19 06:57:54.593400
7019,ML00009252,,,CC(/C=C/C=C(\C)[C@H](O)[C@@H](C)[C@@H]1C[C@H](O)[C@@]2(C)O[C@@H]2/C=C\[C@@H](C)[C@H](O)C[C@H](CC(=O)O)C/C=C\C(=O)O1)=C\c1coc(C)n1,standard_macrolactone,16.0,,,success,,6.0,"[3, 5, 6, 10, 11, 13]",ring_size_16/standard/numbered/ML00009252_numbered.png,2026-03-19 06:57:54.632166
7020,ML00000642,CHEMBL1939384,,Cc1cc(C)c2cc1C(=O)NCCOC(=O)NCCSc1cc-2nc(N)n1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7021,ML00001481,CHEMBL84845,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccc(NC(=O)OCC3c4ccccc4-c4ccccc43)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)C2OC2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7022,ML00007183,,,C/C1=C/C[C@@H](/C(C)=C/c2coc(C)n2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007183_numbered.png,2026-03-19 06:57:54.693854
7023,ML00007160,,,C/C1=C/C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)/C(C)=C/CC1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007160_numbered.png,2026-03-19 06:57:54.742843
7024,ML00008994,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCNCCN(C)C)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00008994_numbered.png,2026-03-19 06:57:54.794788
7025,ML00010645,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(=O)/C=C\c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7026,ML00002043,CHEMBL4094405,,CC(C)S(=O)(=O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1cccc(C(N)=O)c1)c1ccc(cc1)CCOC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7027,ML00009392,,,C/C=C/C=C/C=C/C(=O)NC(Cc1ccccc1)C(=O)NC1COC(=O)C2CCCN2C(=O)C(C)NC(=O)C(C)N(C)C(=O)C2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7028,ML00001119,CHEMBL558945,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2OC(c3ccccc3)=N[C@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00001119_numbered.png,2026-03-19 06:57:54.859566
7029,ML00002291,,,CO[C@@H]1[C@@H](OC2OC(C)C(OC3CC(C)(O)C(OC(=O)CC(C)C)C(C)O3)C(N(C)C)C2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C2O[C@H]2C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002291_numbered.png,2026-03-19 06:57:54.907239
7030,ML00002017,CHEMBL86941,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7031,ML00009566,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(C)CCN(C)C(=O)CN)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009566_numbered.png,2026-03-19 06:57:54.968361
7032,ML00006806,,,Cc1cc(Cl)ccc1OCC(=O)O/N=C1\CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006806_numbered.png,2026-03-19 06:57:54.994694
7033,ML00001355,CHEMBL88030,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](CCc2ccccc2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7034,ML00002131,CHEMBL402921,,CN(c1cc2cc(c1)C(=O)N[C@@H](c1ccccc1)CCc1cccc(c1)C[C@@](C)(N)C(=O)OC2)S(=O)(=O)CC(F)(F)F,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7035,ML00000277,CHEMBL3935309,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(OC(F)(F)F)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7036,ML00009063,,,CC[C@@H]1OC(=O)C[C@@H](O)[C@H](C)[C@H](O[C@H]2O[C@H](C)[C@@H](O[C@H]3CC[C@@H](O)[C@H](C)O3)[C@H](N)[C@H]2O)[C@H](CC=O)C[C@H](C)C(=O)/C=C\[C@]2(C)O[C@@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009063_numbered.png,2026-03-19 06:57:55.089523
7037,ML00003896,,,CCC(=O)O[C@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@H](O[C@H]3[C@@H](OC)[C@@H](OC(C)=O)CC(=O)O[C@@H](C)C/C=C\C=C/[C@@H](O)[C@@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003896_numbered.png,2026-03-19 06:57:55.147082
7038,ML00006601,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006601_numbered.png,2026-03-19 06:57:55.214575
7039,ML00007124,,,CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCC(=O)O)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7040,ML00008161,,,C[C@@H]1CC[C@H](O)CCC(=O)O[C@H](C)CC[C@H](O)CCC(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7041,ML00008843,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(C#Cc3ccccc3)OS(C)(=O)=O)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7042,ML00002333,,,CCCCC(=O)O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002333_numbered.png,2026-03-19 06:57:55.312080
7043,ML00008821,,,COc1ccc(C[C@H]2NC(=O)/C=C\C[C@@H]([C@H](C)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7044,ML00009362,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](C(C)(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7045,ML00010566,,,CC[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](CO)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010566_numbered.png,2026-03-19 06:57:55.385128
7046,ML00003054,,,CO[C@@H]1[C@@H](OC2OC(C)C(OC3CC(C)(O)C(OC(=O)CC(C)C)C(C)O3)C(N(C)C)C2O)[C@@H](CCN)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003054_numbered.png,2026-03-19 06:57:55.437388
7047,ML00010955,,,CC[C@H]1OC(=O)CC[C@H](C)C(O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 6, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00010955_numbered.png,2026-03-19 06:57:55.495932
7048,ML00008987,,,CO[C@@H](/C(C)=C/C=C/C(C)=C/c1coc(C)n1)[C@@H](C)[C@@H]1C[C@H](O)[C@@]2(C)O[C@@H]2/C=C\[C@@H](C)[C@H](O)C[C@H](CC(=O)O)C/C=C\C(=O)O1,standard_macrolactone,16.0,,,success,,6.0,"[3, 5, 6, 10, 11, 13]",ring_size_16/standard/numbered/ML00008987_numbered.png,2026-03-19 06:57:55.546797
7049,ML00009088,,,COC1CC(C)OC(OC2C(C)/C=C\C(=O)OC(C)C(COC3OC(C)C(O)C(OC)C3OC)C3OC3/C=C\C(=O)C(C)(O)CC2C)C1O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009088_numbered.png,2026-03-19 06:57:55.602069
7050,ML00009379,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC(=O)Nc1cc(F)cc(F)c1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009379_numbered.png,2026-03-19 06:57:55.664519
7051,ML00008242,,,C[C@@H]1CCC(=O)/C=C\C(=O)O[C@H](C)CC[C@H](O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7052,ML00002273,,,CCC(=O)O[C@@H]1/C=C\[C@@H]2O[C@H]2C[C@@H](C)OC(=O)C[C@H](OC(C)=O)[C@H](OC)[C@H](O[C@@H]2O[C@H](C)[C@H](O[C@@H]3C[C@](C)(O)[C@@H](OC(C)=O)[C@H](C)O3)[C@H](N(C)C)[C@@H]2O)[C@H](CC=O)C[C@@H]1C,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002273_numbered.png,2026-03-19 06:57:55.726931
7053,ML00004473,,,CCC(=O)O[C@@H]1CC(=O)O[C@@H](C/C=C/c2cnc3ccccc3c2)CCCN(C)C[C@H](O)[C@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(OC(=O)CC)[C@@H](OC(=O)NC)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H]1OC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7054,ML00003271,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccc(COC(=O)CN)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7055,ML00003268,,,CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](CC)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7056,ML00004451,,,CC[C@@H]1[C@@H](C)O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C=C/C=C/[C@H](C)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]3(O)C[C@@H](O[C@H]4C[C@H](O)[C@H](O)[C@H](C)O4)[C@H](C)[C@@H](C)O3)OC(=O)/C=C/C=C/[C@@H]2C)C[C@H]1O[C@H]1C[C@H](O)[C@H](O)[C@H](C)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7057,ML00001339,CHEMBL60396,,O=C(NC(Cc1ccccc1)C(O)CN1CCCCCCCCC/C=C/CC(c2ccccc2)OC1=O)O[C@H]1CO[C@H]2OCC[C@@H]12,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7058,ML00004735,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=N\OCC(=O)N2CCN(c3ccccc3)CC2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004735_numbered.png,2026-03-19 06:57:55.834171
7059,ML00001281,CHEMBL3251859,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](N(C)C)[C@@H](OC(=O)CC)[C@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)O[C@@H]2C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001281_numbered.png,2026-03-19 06:57:55.883278
7060,ML00008458,,,C[C@H]1/C=C\C(=O)O[C@H](C)[C@@H](C)/C=C\C=C/C(=O)[C@H](C)C[C@H](C)[C@@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00008458_numbered.png,2026-03-19 06:57:55.926909
7061,ML00003281,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=N\OCCOc2ccccc2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003281_numbered.png,2026-03-19 06:57:55.986927
7062,ML00003544,,,C/C=C/C=C/C=C\C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)[C@H]2C[C@H](C)CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)[C@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7063,ML00010245,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@]56OCC[C@@]7(O[C@@H]7C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)[C@H]5OC(=O)[C@@H]6O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7064,ML00002396,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC(=O)C[C@@H]3SC[C@@H](C(=O)O)NC3=O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00002396_numbered.png,2026-03-19 06:57:56.055939
7065,ML00005103,,,C/C=C(\NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCN1C(=O)/C(=C/C)NC(=O)CC(O)CCCCC)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCO)C(=O)N[C@H](CCN)C(=O)N[C@@H](CCCCN)C(=O)O[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7066,ML00006373,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)C=C(C)C)C(C)C)[C@@H](C)OC(=O)[C@H](CCCCc2ccc(O)cc2)NC(=O)[C@@H](CCC(=O)O)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7067,ML00007024,,,CCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)C2=N[C@@](C)(CS2)C(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7068,ML00002666,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](C/C=C/C(=O)O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002666_numbered.png,2026-03-19 06:57:56.144427
7069,ML00000289,CHEMBL3808399,,C[C@H]1COC(=O)Nc2cccc(c2)CNC(=O)C(Nc2ccc3c(N)nccc3c2)c2ccc1cc2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7070,ML00003226,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=N/OCC#Cc2cnc3ccccc3c2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003226_numbered.png,2026-03-19 06:57:56.202917
7071,ML00001336,CHEMBL3342325,,C/C=C/C=C/C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7072,ML00000237,CHEMBL1975251,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7073,ML00009277,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C=C=CC(C)=O)C[C@@H](C)C(=O)CC[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009277_numbered.png,2026-03-19 06:57:56.266522
7074,ML00002117,CHEMBL1235782,SORAPHEN A,CO[C@H]1CCCC[C@@H](c2ccccc2)OC(=O)[C@@H](C)[C@@]2(O)O[C@@H]([C@@H](C)/C=C/[C@H]1OC)[C@@H](C)[C@H](O)[C@H]2OC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7075,ML00002923,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002923_numbered.png,2026-03-19 06:57:56.319818
7076,ML00001678,CHEMBL399595,,CN(c1cc2cc(n1)CCCCCc1cccc(c1)C[C@@](C)(N)C(=O)OC2)S(C)(=O)=O,standard_macrolactone,16.0,,,success,,2.0,"[16, 16]",ring_size_16/standard/numbered/ML00001678_numbered.png,2026-03-19 06:57:56.345485
7077,ML00010517,,,COC1C(OCC2C(C)OC(=O)/C=C\C(C)C(OC3OC(C)CC(O)C3O)CCC(C)C(=O)/C=C\C3OC32)OC(C)C(O)C1O,standard_macrolactone,16.0,,,success,,6.0,"[3, 4, 9, 10, 13, 14]",ring_size_16/standard/numbered/ML00010517_numbered.png,2026-03-19 06:57:56.384781
7078,ML00002688,,,CC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](C)C[C@@H](C)C(=O)C[C@H](SC[C@@H](NC(C)=O)C(=O)O)[C@H]2O[C@@H]2[C@]1(O)CO[C@H]1O[C@@H](C)[C@H](O)[C@@H](OC)[C@@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 4, 7, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00002688_numbered.png,2026-03-19 06:57:56.438701
7079,ML00003493,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@H](OC(C)=O)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003493_numbered.png,2026-03-19 06:57:56.488799
7080,ML00002020,CHEMBL4088154,,Cc1cc2cc(C)c1CCOC(=O)Nc1cccc(c1)[C@H]1CCCN1C(=O)[C@@H]2Nc1ccc2cc[nH]c(=O)c2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7081,ML00004657,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)Cc4ccccc4)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004657_numbered.png,2026-03-19 06:57:56.557476
7082,ML00009303,,,COc1ccc(C[C@H]2NC(=O)/C=C\C[C@@H](C[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7083,ML00009358,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)C3OC3c3ccccc3)OC(=O)[C@H](CC(C)C)NC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7084,ML00002557,,,CO[C@@H]1[C@@H](O)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O[C@@H]2C[C@](C)(O)[C@H](O)CO2)[C@H](C)C[C@H](CCO)[C@H]1O[C@H]1O[C@H](C)[C@H](O[C@H]2C[C@@](C)(O)[C@H](O)[C@H](C)O2)[C@H](N(C)C)[C@@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002557_numbered.png,2026-03-19 06:57:56.622141
7085,ML00004375,,,CC[C@@H]1[C@@H](C)O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C=C\C=C/[C@@H](C)[C@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]3(O)C[C@@H](O[C@H]4C[C@H](O)[C@H](O)[C@H](C)O4)[C@H](CC)[C@@H](C)O3)OC(=O)/C=C\C=C/[C@@H]2C)C[C@H]1O[C@H]1C[C@H](O)[C@H](O)[C@H](C)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7086,ML00007042,,,CC1CCC(NS(=O)(=O)c2ccccc2[N+](=O)[O-])CCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/ML00007042_numbered.png,2026-03-19 06:57:56.658895
7087,ML00005941,,,CO/C1=C/C(C)=C\C(C)C(O)C(C)C/C(C)=C\C=C/C(OC)C(C(C)C(O)C(C)C2(OC)CC(OC(=O)/C=C/C(=O)NC3=C(O)CCC3=O)C(C)C(C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00005941_numbered.png,2026-03-19 06:57:56.705384
7088,ML00010944,,,CCC1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/[C@]2(C)OC2C1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010944_numbered.png,2026-03-19 06:57:56.759674
7089,ML00003546,,,C/C=C/C=C/C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](C)NC(=O)[C@@H](C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7090,ML00006261,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](OC(C)=O)[C@H](N(C)C)[C@H]2OC(C)=O)[C@@H](CCOc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006261_numbered.png,2026-03-19 06:57:56.825195
7091,ML00001112,CHEMBL1915490,PORPOISAMIDE A,CCCCC[C@H]1NC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)OC(=O)[C@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7092,ML00002733,,,COC1CC(C)CC(C)[C@@H](O)[C@@H](C)CC(C)CCCC(OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(OC)C[C@@H](C(=O)Oc3ccccc3)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00002733_numbered.png,2026-03-19 06:57:56.883922
7093,ML00002124,CHEMBL392564,,CN(c1cc2cc(c1)C(C(F)(F)F)N[C@@H](c1ccccc1)CCc1cccc(c1)C[C@@](C)(N)C(=O)OC2)S(C)(=O)=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7094,ML00008240,,,C[C@H]1C/C=C\C(=O)O[C@@H](C)CC(=O)O[C@@H](C)[C@H](O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7095,ML00007557,,,C/C=C1\NC(=O)[C@@H](CS)NC(=O)[C@@H](C(C)C)CC(=O)C[C@@H](/C=C/CCS)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7096,ML00002917,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)/C=C\C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002917_numbered.png,2026-03-19 06:57:56.962072
7097,ML00000733,CHEMBL152512,,CC(C)C[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7098,ML00005784,,,CCOC(=O)C1CS/C(=C/C[C@@H]2CC[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]3O)[C@@H](C)[C@H](O)CC(=O)O[C@H](CC)[C@@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)/C=C(C)/C=C/C2=O)N1,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 6, 9, 10, 13, 14, 15]",ring_size_16/standard/numbered/ML00005784_numbered.png,2026-03-19 06:57:57.029476
7099,ML00004179,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](CC=O)C[C@@H](C)C(=O)CCC(C)C[C@@H]1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004179_numbered.png,2026-03-19 06:57:57.090166
7100,ML00010374,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@]5([C@H](C)O)OCC/C(=C/C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)[C@H]5O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7101,ML00001784,CHEMBL442238,,CC(C)N1CCCCc2cccc(c2)C[C@@](C)(N)C(=O)OCc2cc1nc(N(C)S(C)(=O)=O)c2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7102,ML00004822,,,CCCO[C@H]1[C@H](N(C)C)[C@@H](OCCC)[C@H](O[C@@H]2[C@@H](C)[C@H](O)CC(=O)O[C@H](CC)[C@@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)/C=C(C)/C=C/C(=O)[C@H](C)C[C@@H]2CCN2C(=O)c3ccccc3C2=O)O[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004822_numbered.png,2026-03-19 06:57:57.165486
7103,ML00009327,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@](C)(O)C#Cc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7104,ML00003270,,,CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](C)NC(=O)[C@@H]2CCCCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7105,ML00009062,,,CC[C@@H]1OC(=O)/C=C\[C@H](C)[C@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](C)C[C@@H](C)C(=O)/C=C\C=C/[C@@]1(O)CO[C@@H]1O[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]1O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009062_numbered.png,2026-03-19 06:57:57.231605
7106,ML00001387,CHEMBL86423,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7107,ML00001050,CHEMBL1475395,,CO[C@H]1COC(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7108,ML00010808,,,C=C1[C@@H](C)[C@H]2[C@H](Cc3ccccc3)NC(=O)[C@]23OOC(=O)C[C@@H]2O/C2=C(\C=O)CCC[C@@H](C)C/C=C\[C@@H]3[C@@H]1O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7109,ML00001301,CHEMBL3244602,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(=O)CCl)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001301_numbered.png,2026-03-19 06:57:57.308785
7110,ML00002997,,,C=C1Oc2cc(OC)cc(C(=O)O[C@@H]3COC(=O)C[C@H](N)c4cc(O)c(c(Cl)c4)O[C@@H]4C#C/C=C/3C#CC3=CC=C[C@@]34O[C@H]3OC(C)(C)[C@H](N(C)C)[C@H](O)[C@@H]3O)c2NC1=O,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7111,ML00002703,,,CCC(=O)O[C@H]1CC(=O)O[C@H](C)C/C=C\C=C/C(=O)[C@@H](C)C[C@@H](CC=O)[C@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](OC(=O)CC(C)C)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002703_numbered.png,2026-03-19 06:57:57.373437
7112,ML00009592,,,COC(=O)[C@@H]1C[C@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@@H]2OC)O[C@H](C(C)C)[C@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009592_numbered.png,2026-03-19 06:57:57.425542
7113,ML00009006,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCNC(C)(C)C)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009006_numbered.png,2026-03-19 06:57:57.476785
7114,ML00010111,,,CC(=O)N[C@H](C)[C@@H](O)[C@@H](C)[C@@H]1OC(=O)CC/C=C(C)\C=C\[C@]2(C)CCC=C[C@@H]2/C=C(C)/C=C/[C@H]1C,standard_macrolactone,16.0,,,success,,5.0,"[3, 4, 7, 10, 13]",ring_size_16/standard/numbered/ML00010111_numbered.png,2026-03-19 06:57:57.512839
7115,ML00008975,,,CO/C1=C/C=C(/C)C(C)C(O)C(C)C/C(C)=C\C=C/C(OC)C(C(C)C(O)C(C)C2(O)CC(O)C(C)C(C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 13, 16]",ring_size_16/standard/numbered/ML00008975_numbered.png,2026-03-19 06:57:57.558517
7116,ML00004623,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCCc4ccnc5ccccc45)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004623_numbered.png,2026-03-19 06:57:57.614642
7117,ML00005762,,,CCCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/C(=O)[C@@H](C)C[C@@H](CC=O)[C@H](O[C@@H]2O[C@@H](C)[C@@H](O[C@@H]3C[C@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005762_numbered.png,2026-03-19 06:57:57.661041
7118,ML00003460,,,COC1C(OC(C)=O)CC(=O)OC(C)CC2OC2/C=C\C(=O)C(C)CC(CC=O)C1OC1OC(C)C(OC2CC(C)(O)C(OC(C)=O)C(C)O2)C(N(C)C)C1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003460_numbered.png,2026-03-19 06:57:57.705856
7119,ML00009126,,,CC(C)C[C@@H]1OC(=O)[C@H](C)CNC(=O)[C@@H](Cc2cc(Cl)c(O)c(Cl)c2)NC(=O)/C=C\C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7120,ML00008540,,,CC(=O)O[C@@H]1/C=C\C(=O)O[C@H](C)CC[C@H](O)/C=C\C(=O)O[C@H](C)CC1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7121,ML00001321,CHEMBL89788,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](COCc2ccccc2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7122,ML00006158,,,CCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](OC)[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(=O)CC)[C@H](C)C[C@@H]2CC=O)O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O2)[C@@H]1N(C)C,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006158_numbered.png,2026-03-19 06:57:57.770013
7123,ML00007319,,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)CNC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7124,ML00002996,,,C=C1Oc2cc(OC)cc(C(=O)O[C@H]3COC(=O)C[C@H](N)c4cc(O)c(c(Cl)c4)O[C@@H]4C#C/C=C/3C#CC3=CC=C[C@@]34O[C@H]3OC(C)(C)[C@H](N(C)C)[C@H](O)[C@@H]3O)c2NC1=O,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7125,ML00007316,,,CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCSCc2ccccc2O)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7126,ML00002016,CHEMBL86873,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7127,ML00002137,,,CO[C@H]1/C=C\C=C(\C)C[C@H](C)[C@H](O)[C@H](C)/C=C(C)\C=C(\C)C(=O)O[C@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](OC(=O)/C=C/C2=CC(=O)OC2=O)[C@H](C)[C@@H](C(C)C)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00002137_numbered.png,2026-03-19 06:57:57.840057
7128,ML00005651,,,CCCCC(=O)O[C@@H]1[C@@H](C)O[C@@H](O[C@H]2[C@H](C)O[C@H](O[C@H]3[C@@H](OC)[C@@H](O)CC(=O)O[C@@H](C)C/C=C\C=C/[C@@H](OC(C)=O)[C@@H](C)C[C@@H]3CC=O)[C@@H](OC(C)=O)[C@@H]2N(C)C)C[C@@]1(C)OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005651_numbered.png,2026-03-19 06:57:57.886419
7129,ML00003532,,,CCC/C=C/C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7130,ML00006214,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=N\OCCCc2ccc3ncccc3c2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006214_numbered.png,2026-03-19 06:57:57.946453
7131,ML00007645,,,C/C(=C\c1csc(C)n1)[C@@H]1C/C=C\CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007645_numbered.png,2026-03-19 06:57:57.995755
7132,ML00003295,,,CO[C@H]1/C=C/C=C(\C)C[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C=C(\C)C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](OC(=O)/C=C/C(=O)O)[C@H](C)[C@@H](C(C)C)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00003295_numbered.png,2026-03-19 06:57:58.050748
7133,ML00002786,,,CC[C@@H]1O[C@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(C)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H]2OC)C[C@H](OC(=O)/C=C/C(=O)NC2=C(O)CCC2=O)[C@@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00002786_numbered.png,2026-03-19 06:57:58.104674
7134,ML00007334,,,C/C1=C/[C@H](C)C[C@H](C)[C@H](Cc2cnco2)OC(=O)/C(C)=C\[C@H](C)C[C@H](C)[C@H](Cc2cnco2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7135,ML00003908,,,CCCCC(=O)O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003908_numbered.png,2026-03-19 06:57:58.166117
7136,ML00009051,,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](CC2CCCCC2)NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7137,ML00009380,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2OC(c3ccc(C(C)(C)C)cc3)=N[C@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00009380_numbered.png,2026-03-19 06:57:58.227933
7138,ML00001048,CHEMBL1435684,,CO[C@H]1COC(=O)CCC[C@H](C)[C@@H](OC)COC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7139,ML00000984,CHEMBL3809344,,CC1(C)COC(=O)Nc2cccc(c2)CNC(=O)[C@@H](Nc2ccc3c(N)nccc3c2)c2ccc1cc2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7140,ML00001421,CHEMBL159377,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)C[C@@H](CC(C)C)NC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7141,ML00008465,,,CC(=O)C[C@@H]1CCC(=O)/C=C\C(=O)O[C@H](CC(C)=O)CC[C@@H](O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7142,ML00010646,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(=O)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7143,ML00001505,CHEMBL4110913,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(=O)N3CCOCC3)[C@H]2O)[C@](C)(OC)CCC[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCN(Cc3c(Cl)cncc3Cl)c3ccc(OC)c(OC4CCCC4)c3)C(=O)O[C@]12C,standard_macrolactone,16.0,,,success,,11.0,"[3, 4, 6, 7, 8, 12, 12, 13, 14, 15, 16]",ring_size_16/standard/numbered/ML00001505_numbered.png,2026-03-19 06:57:58.339872
7144,ML00010436,,,CC1=CC2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\C56OCCC7(OC7C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)C5OC(O)C6O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7145,ML00002532,,,CCN(CC)Cc1ccc([C@H]2O[C@@H]2[C@@H](C)[C@@H]2C/C=C/C(=O)N[C@H](Cc3ccc(OC)c(Cl)c3)C(=O)NCC(C)(C)C(=O)O[C@@H](CC(C)C)C(=O)O2)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7146,ML00009361,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(O)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7147,ML00003920,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@H](O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003920_numbered.png,2026-03-19 06:57:58.420045
7148,ML00010650,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(=O)C#Cc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7149,ML00005658,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=N\OCCOc2ccccc2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005658_numbered.png,2026-03-19 06:57:58.487598
7150,ML00006597,,,CCC1CC(C)C(=O)/C=C\C(C)=C/C(C)C(CC)OC(=O)CC(O)C(C)C1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006597_numbered.png,2026-03-19 06:57:58.542266
7151,ML00004416,,,CCC(=O)O[C@@H]1CC(=O)O[C@@H](C/C=C/c2cnc3ccccc3c2)CCCN(C)C[C@H](O)[C@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(OC(=O)CC)[C@@H](OC(=O)N(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H]1OC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7152,ML00002238,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC/C=C/c1cnc2ccccc2c1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002238_numbered.png,2026-03-19 06:57:58.613567
7153,ML00001998,CHEMBL4083537,,CC[C@@H]1OC(=O)C[C@@](O)(C/C=C/C=C(\C)[C@H]2OC(=O)CC/C=C(\C)[C@@H](C)[C@H](O)[C@H](C)[C@@H](OC(N)=O)/C=C\C=C/[C@@H]2C)[C@H]1C,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 11, 12, 13]",ring_size_16/standard/numbered/ML00001998_numbered.png,2026-03-19 06:57:58.663517
7154,ML00007643,,,C/C1=C/C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC1,standard_macrolactone,16.0,,,success,,8.0,"[3, 6, 10, 11, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00007643_numbered.png,2026-03-19 06:57:58.716683
7155,ML00009352,,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](c2ccc(O)cc2)NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7156,ML00010464,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C/CC[C@]5(C(=O)CO)OCC/C(=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)[C@H]5O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7157,ML00010363,,,CC(=O)[C@@]12CC/C=C\C(=O)O[C@@H]3C[C@H]4O[C@@H]5[C@@H]6C[C@@]4(O)[C@@]3(C)[C@@]5(CC[C@]6(C)O)COC(=O)/C=C(/CCO1)[C@H]2O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7158,ML00003774,,,CC[C@H]1OC(=O)C[C@@H](O)[C@@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](N(C)C)[C@@H]2O)[C@H](C=O)C[C@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO[C@H]1O[C@@H](C)[C@H](O)[C@@H](OC)[C@@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003774_numbered.png,2026-03-19 06:57:58.800948
7159,ML00001024,CHEMBL96115,,C[C@H]1CCC[C@@]2(C)O[C@H]2C[C@@H](c2ccc3c(c2)ncn3C)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00001024_numbered.png,2026-03-19 06:57:58.858318
7160,ML00002714,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=O)/C=C/C=C/[C@@H]1COc1ccccc1,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002714_numbered.png,2026-03-19 06:57:58.915383
7161,ML00003669,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CCCCCCC2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003669_numbered.png,2026-03-19 06:57:58.976478
7162,ML00005535,,,CCCN(CCC)CC[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](COC2O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]2OC)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)[C@H](O)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005535_numbered.png,2026-03-19 06:57:59.038761
7163,ML00008972,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00008972_numbered.png,2026-03-19 06:57:59.092220
7164,ML00001696,CHEMBL4089042,,CCC(=O)CC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)C2=N[C@@](C)(CS2)C(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7165,ML00004470,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@@H]4OC(=O)N(CCCCc5ccccc5)[C@@H]4/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004470_numbered.png,2026-03-19 06:57:59.154633
7166,ML00003297,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc(OC(C)=O)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003297_numbered.png,2026-03-19 06:57:59.214697
7167,ML00006613,,,COC(=O)c1ccccc1S(=O)(=O)NC1CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006613_numbered.png,2026-03-19 06:57:59.242853
7168,ML00005652,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCNCCc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005652_numbered.png,2026-03-19 06:57:59.304701
7169,ML00005507,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@H](O[C@H]2O[C@@H](C)[C@H](O[C@@H]3CC[C@@H](O)[C@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@H](CC=O)C[C@H](C)C(=O)/C=C\[C@]2(C)O[C@H]2[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005507_numbered.png,2026-03-19 06:57:59.369531
7170,ML00003714,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(CCCN(C)C)C(=O)CN)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003714_numbered.png,2026-03-19 06:57:59.427452
7171,ML00002721,,,CCC(=O)O[C@@H]1CC(=O)O[C@@H](C)C/C=C\C=C/C(=O)[C@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@H](C)[C@@H](O[C@H]3C[C@](C)(O)[C@H](OC(=O)CC(C)C)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002721_numbered.png,2026-03-19 06:57:59.476799
7172,ML00001125,CHEMBL3983744,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1cc(F)c(OC[C@H](C)O)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7173,ML00000079,CHEMBL94599,,C/C(=C\c1ccccn1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00000079_numbered.png,2026-03-19 06:57:59.533024
7174,ML00001354,CHEMBL313117,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](CCc2ccccc2)NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7175,ML00003249,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccc(CNCCN)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7176,ML00005537,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=O)/C=C/C=C/[C@@H]1CNN1CCC2CCCCC21,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005537_numbered.png,2026-03-19 06:57:59.598367
7177,ML00004896,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004896_numbered.png,2026-03-19 06:57:59.659014
7178,ML00005763,,,CCCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/C(=O)[C@H](C)C[C@H](CC=O)[C@@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](OC(=O)CC(C)C)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005763_numbered.png,2026-03-19 06:57:59.708520
7179,ML00004447,,,CC[C@H]1OC(=O)C[C@@H](OC(C)=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004447_numbered.png,2026-03-19 06:57:59.763699
7180,ML00008952,,,COC(=O)C[C@@H]1C/C=C\C(=O)O[C@@H]([C@H](C)[C@@H](O)/C(C)=C/C=C/C(C)=C/c2coc(C)n2)C[C@H](O)[C@]2(C)O[C@@H]2/C=C\[C@@H](C)[C@H](O)C1,standard_macrolactone,16.0,,,success,,6.0,"[3, 5, 6, 10, 11, 13]",ring_size_16/standard/numbered/ML00008952_numbered.png,2026-03-19 06:57:59.803121
7181,ML00004381,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=N\OCc2ccc(F)cc2)/C=C/C(C)=C/C1CO[C@@H]1C[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004381_numbered.png,2026-03-19 06:57:59.857840
7182,ML00009009,,,CCC[C@H]1C[C@H]2CC[C@@H](O2)[C@H](C)C(=O)O[C@H]([C@H](C)[C@H]2CC[C@@H](C[C@@H](CCC)N(C)C)O2)[C@H](C)[C@H]2CC[C@H](O2)[C@@H](C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7183,ML00008414,,,CC[C@@H]1OC(=O)CCC/C=C\C/C=C\C/C=C\[C@H]2[C@H]1C[C@@H]1O[C@@H]12,standard_macrolactone,16.0,,,success,,1.0,[3],ring_size_16/standard/numbered/ML00008414_numbered.png,2026-03-19 06:57:59.886898
7184,ML00010627,,,CC(=O)O[C@@H](C)[C@@]12/C=C\C=C/C(=O)O[C@@H]3C[C@H]4O[C@@H]5C=C(C)CC[C@]5(COC(=O)C=C(CCO1)[C@@H]2OC(C)=O)[C@]3(C)[C@]41CO1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7185,ML00001126,CHEMBL3969432,,COC[C@H](C)Oc1c(F)cc2cc1CN(C)C(=O)[C@H](Nc1ccc3c(N)nccc3c1)c1ccc(c(C)c1)[C@@H](C)COC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7186,ML00010721,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](OC(C)=O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010721_numbered.png,2026-03-19 06:57:59.944469
7187,ML00009328,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@@](C)(O)C#Cc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7188,ML00003447,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN=[N+]=[N-])C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003447_numbered.png,2026-03-19 06:58:00.002942
7189,ML00009603,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(=O)C2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009603_numbered.png,2026-03-19 06:58:00.053886
7190,ML00003543,,,C/C=C/C=C\C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7191,ML00003264,,,CCCC/C=C/C(=O)N[C@@H](Cc1cccc(F)c1)C(=O)N[C@@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)C2(C(C)C2C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7192,ML00007698,,,CCCCCC1/C=C/C#CCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,1.0,[3],ring_size_16/standard/numbered/ML00007698_numbered.png,2026-03-19 06:58:00.089495
7193,ML00003918,,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](N3CCCCC3)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00003918_numbered.png,2026-03-19 06:58:00.135570
7194,ML00007041,,,CC1CCC(NS(=O)(=O)c2cccc([N+](=O)[O-])c2)CCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/ML00007041_numbered.png,2026-03-19 06:58:00.161422
7195,ML00009646,,,CCC[C@@H]1OC(=O)[C@H](C)[C@H]2CC[C@H](O2)[C@@H](C)[C@H]([C@H](C)[C@H]2CC[C@@H](C[C@@H](CCC)N(C)C)O2)OC(=O)[C@@H](C)[C@H]2CC[C@H](O2)[C@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7196,ML00002514,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccc(CN4CCNCC4)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7197,ML00009624,,,CO[C@H]1[C@H](O)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@H](CC=O)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009624_numbered.png,2026-03-19 06:58:00.217932
7198,ML00001563,CHEMBL3244608,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](N(C)C)[C@@H](OC(=O)CCCC(=O)O)[C@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)O[C@@H]2C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001563_numbered.png,2026-03-19 06:58:00.263154
7199,ML00000257,CHEMBL378243,,CN1C2CCC1C1COC(=O)CCSCCC(=O)Nc3ccc(cc3)C1C2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7200,ML00003066,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@@]2(O)C[C@@H](O[C@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@@H]3OC)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00003066_numbered.png,2026-03-19 06:58:00.315880
7201,ML00002570,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOC(C)=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002570_numbered.png,2026-03-19 06:58:00.367760
7202,ML00007673,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H](O)[C@@H](O)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)C(O)CC(=O)O1,standard_macrolactone,16.0,,,success,,10.0,"[3, 5, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007673_numbered.png,2026-03-19 06:58:00.418629
7203,ML00006960,,,CC[C@@H]1C[C@H](C)C(=O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@H](OC)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006960_numbered.png,2026-03-19 06:58:00.459880
7204,ML00007699,,,CC(C)[C@H]1NC(=O)[C@@H](C)NC(=O)[C@@H](C)NC(=O)C[C@H](/C=C/CCS)OC(=O)CNC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7205,ML00000175,CHEMBL196586,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2C[C@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)CCC(=O)O1,standard_macrolactone,16.0,,,success,,7.0,"[3, 10, 11, 12, 13, 14, 14]",ring_size_16/standard/numbered/ML00000175_numbered.png,2026-03-19 06:58:00.505875
7206,ML00000408,CHEMBL1594011,,Cc1ccc(S(=O)(=O)N[C@H]2COC(=O)C/C=C\[C@H](C)[C@@H](NS(=O)(=O)c3ccc(C)cc3)COC(=O)C/C=C\[C@@H]2C)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7207,ML00001390,CHEMBL314688,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H]2O[C@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7208,ML00008030,,,O=C1CCCCCCCCCC/C(=N\O)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00008030_numbered.png,2026-03-19 06:58:00.542761
7209,ML00001949,CHEMBL60728,,CC1C/C=C/CCCCCCCCOC(=O)N(CC(O)C(Cc2ccccc2)NC(=O)O[C@H]2CO[C@H]3OCC[C@@H]23)C1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7210,ML00000409,CHEMBL3823627,,CC(=O)N[C@H](C)[C@@H](O)[C@@H](C)[C@@H]1OC(=O)/C=C/C=C(C)/C=C/[C@]2(C)CCC=C[C@@H]2/C=C(C)/C=C/[C@H]1C,standard_macrolactone,16.0,,,success,,5.0,"[3, 4, 7, 10, 13]",ring_size_16/standard/numbered/ML00000409_numbered.png,2026-03-19 06:58:00.589560
7211,ML00004168,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(CCCN(C)C)C(=O)[C@H](C)N)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004168_numbered.png,2026-03-19 06:58:00.645882
7212,ML00008792,,,CO[C@H]1CCCCCCCCC[C@@H](C)OC(=O)/C(C)=C/C1=O,standard_macrolactone,16.0,,,success,,4.0,"[3, 13, 14, 16]",ring_size_16/standard/numbered/ML00008792_numbered.png,2026-03-19 06:58:00.679874
7213,ML00004698,,,CC[C@@H]1[C@@H](C)O[C@@](OC)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C=C\C=C/[C@H](C)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]3(OC)C[C@@H](O[C@H]4C[C@H](O)[C@H](O)[C@H](C)O4)[C@H](CC)[C@@H](C)O3)OC(=O)/C=C\C=C/[C@@H]2C)C[C@H]1OC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7214,ML00000601,CHEMBL3628316,,CC(C)[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)NCc1cc(OC(F)(F)F)ccc1CC(=O)O2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7215,ML00003700,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(C)CCN(C)C(=O)[C@H](C)N)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003700_numbered.png,2026-03-19 06:58:00.744963
7216,ML00010948,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](CC=O)C[C@H](C)C(=O)/C=C\[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010948_numbered.png,2026-03-19 06:58:00.799074
7217,ML00009194,,,CO/C1=C/C(C)=C\C(C)C(O)C(C)C/C(C)=C\C=C/C(OC)C(C(C)C(O)C(C)C(=O)/C=C/C(C)C(C)O)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009194_numbered.png,2026-03-19 06:58:00.854609
7218,ML00004286,,,C/C=C1\NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](C)C[C@@H](C)C[C@@H](C)CCC)[C@H](C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7219,ML00009604,,,CO[C@@H]1[C@H](O[C@@H]2[C@@H](C)/C=C\C(=O)O[C@@H](C)[C@H](CO[C@@H]3O[C@@H](C)C[C@@]4(OC(=O)O[C@H]4C)[C@@H]3O)[C@H]3O[C@H]3CCC(=O)[C@@H](C)C[C@@H]2C)O[C@@H](C)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009604_numbered.png,2026-03-19 06:58:00.924562
7220,ML00002743,,,CCC(=O)O[C@@H]1CC(=O)O[C@@H](C)C/C=C\C=C/[C@H](O)[C@@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@H](C)[C@@H](O[C@H]3C[C@](C)(O)[C@H](OC(=O)CC(C)C)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002743_numbered.png,2026-03-19 06:58:00.982126
7221,ML00010916,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC(N)=O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010916_numbered.png,2026-03-19 06:58:01.044219
7222,ML00002270,,,CCCC(=O)O[C@@H]1[C@H](C)O[C@H](O[C@H]2[C@@H](N(C)C)[C@H](O)[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)O[C@@H]2C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002270_numbered.png,2026-03-19 06:58:01.099585
7223,ML00006277,,,CCCO[C@@H]1[C@@H](N(C)C)[C@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@H](CC)[C@@H](CO[C@@H]2O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]2OC)/C=C(C)/C=C/C(=O)[C@H](C)C[C@@H]1CCCl,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006277_numbered.png,2026-03-19 06:58:01.162243
7224,ML00007259,,,C=C1CC[C@H](Br)[C@@]2(C)CC[C@@H](Br)[C@@](C)(O)CC[C@H](O)C(C)(C)OC(=O)c3ccc(O)c(c3)C[C@H]12,standard_macrolactone,16.0,,,success,,7.0,"[3, 3, 4, 7, 7, 8, 11]",ring_size_16/standard/numbered/ML00007259_numbered.png,2026-03-19 06:58:01.209865
7225,ML00000670,CHEMBL3410868,,COc1ccc(C[C@@H]2NC(=O)/C=C/C[C@@H](c3ccc(Br)cc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7226,ML00002739,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C[C@@H](O)/C=C\C=C/[C@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](OC(=O)CC(C)C)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 5, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002739_numbered.png,2026-03-19 06:58:01.270852
7227,ML00002691,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(OC(C)=O)C(=O)C2OC(C)=O)[C@@H](CC(OC)OC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002691_numbered.png,2026-03-19 06:58:01.329028
7228,ML00007080,,,CC[C@H]1OC(=O)C[C@H](O)[C@H](C)C(=O)[C@@H](C)C[C@@H](C)[C@H](O)/C=C\C=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00007080_numbered.png,2026-03-19 06:58:01.380039
7229,ML00000291,CHEMBL1173195,,CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)-c2nc(cs2)C(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7230,ML00003533,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC(=O)NCc1ccccc1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003533_numbered.png,2026-03-19 06:58:01.442146
7231,ML00006858,,,Cc1ccccc1OCC(=O)ON=C1CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006858_numbered.png,2026-03-19 06:58:01.465984
7232,ML00007352,,,CC[C@@H]1/C=C\[C@H]([C@H](C)O)OC(=O)/C(C)=C\[C@H]2C(=O)NC3=CC(=O)c4c(cc(C)c(O)c4C(=O)CC1)[C@@]32O,standard_macrolactone,16.0,,,success,,5.0,"[3, 6, 9, 13, 16]",ring_size_16/standard/numbered/ML00007352_numbered.png,2026-03-19 06:58:01.503218
7233,ML00008802,,,C[C@@H]1CCCCCCCCC[C@H](O)C(=O)CC(SCC(F)(F)F)C(=O)O1,standard_macrolactone,16.0,,,success,,4.0,"[3, 13, 14, 16]",ring_size_16/standard/numbered/ML00008802_numbered.png,2026-03-19 06:58:01.535140
7234,ML00002520,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](OC(=O)CCc3ccccc3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](OC(C)=O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002520_numbered.png,2026-03-19 06:58:01.580739
7235,ML00009066,,,CC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\C=C/[C@@H]1O[C@H]1O[C@@H](C)[C@H](O)[C@@H](OC)[C@@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009066_numbered.png,2026-03-19 06:58:01.626080
7236,ML00010587,,,CCC[C@@H](CC[C@@H](C)[C@@H]1OC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@]2(C)CSC(=N2)[C@H](C)NC(=O)C1(C)C)OC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7237,ML00002655,,,CCC(=O)O[C@H]1CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H](O[C@H]2O[C@H](C)[C@@H](O[C@H]3C[C@](C)(O)[C@H](OC(=O)CC)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002655_numbered.png,2026-03-19 06:58:01.680682
7238,ML00009320,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7239,ML00005989,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3CC(C)(O)[C@@H](O)[C@@H](C)O3)C(N(C)C)C2C)[C@@H](CC=O)C[C@@H](C)[C@@H](O[C@H]2CC[C@H](N(C)C)C(C)O2)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005989_numbered.png,2026-03-19 06:58:01.740056
7240,ML00004426,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)CCCN(CCCCc4ccccc4)C[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(C)=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7241,ML00010857,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/[C@@H]2O[C@H]2C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010857_numbered.png,2026-03-19 06:58:01.797991
7242,ML00010961,,,CCC(=O)O[C@H]1CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@@H](N(C)C)[C@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010961_numbered.png,2026-03-19 06:58:01.848218
7243,ML00005504,,,CC[C@H]1OC(=O)C[C@@H](O)[C@@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](O)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@H](CC=O)C[C@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO[C@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005504_numbered.png,2026-03-19 06:58:01.905603
7244,ML00004138,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](OC(=O)Nc3ccc(C(F)(F)F)cc3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](OC(C)=O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004138_numbered.png,2026-03-19 06:58:01.954425
7245,ML00005791,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=O)/C=C/C=C/[C@@H]1COC1OC(C)C=CC1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005791_numbered.png,2026-03-19 06:58:02.006454
7246,ML00010886,,,CC[C@@H]1OC(=O)C[C@H](O)[C@@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](N(C)C)[C@@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\[C@H]2O[C@@H]2[C@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010886_numbered.png,2026-03-19 06:58:02.057449
7247,ML00002097,CHEMBL155058,,CC(C)C[C@@H]1NC(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7248,ML00005418,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=N/OCCCCc2ccc3ncccc3c2)/C=C/C(C)=C/C1CO[C@@H]1C[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005418_numbered.png,2026-03-19 06:58:02.129180
7249,ML00006439,,,CCC1OC(=O)CC(O)C(C)C(OC2OC(C)C(OC3CC(C)(O)C(O)C(C)O3)C(N(C)C)C2O)C(CCO)CC(C)C(=O)/C=C\C(C)=C/C1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006439_numbered.png,2026-03-19 06:58:02.187432
7250,ML00001562,CHEMBL3251857,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2OC(C)=O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001562_numbered.png,2026-03-19 06:58:02.236057
7251,ML00001189,CHEMBL3922904,,Cc1cc2ccc1[C@@H](C(F)F)COC(=O)Nc1ccc(S(=O)(=O)C3CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7252,ML00009523,,,CCC[C@@H]1OC(=O)[C@H](CC)[C@H]2CC[C@H](O2)[C@@H](C)[C@H]([C@H](C)[C@H]2CC[C@@H](C[C@@H](CCC)N(C)C)O2)OC(=O)[C@@H](C)[C@H]2CC[C@H](O2)[C@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7253,ML00009803,,,CO[C@H]1[C@H](OC[C@H]2/C=C/C=C/C(=O)[C@@](C)(O)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@](O)([C@H](C)O)[C@H]3O)[C@@H](C)/C=C/C(=O)O[C@@H]2C)O[C@H](C)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009803_numbered.png,2026-03-19 06:58:02.301002
7254,ML00009587,,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(OC)C[C@@H](OC)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009587_numbered.png,2026-03-19 06:58:02.350445
7255,ML00003874,,,CCC(=O)O[C@@H]1[C@@H](C)O[C@@H](O[C@H]2[C@H](C)O[C@H](O[C@H]3[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C\[C@H]4O[C@H]4C[C@@H](C)OC(=O)C[C@@H](OC(C)=O)[C@H]3OC)[C@@H](O)[C@@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003874_numbered.png,2026-03-19 06:58:02.396867
7256,ML00006711,,,O=C1CCCCCCCCCCC(=NOC(=O)COc2cccc(Cl)c2)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006711_numbered.png,2026-03-19 06:58:02.419225
7257,ML00000773,CHEMBL2324839,,C=CCOC(=O)CCC[C@@H]1CNC(=O)[C@@H](Cc2ccc(OC)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7258,ML00010168,,,CCS(=O)(=O)c1ccc2cc1CNC(=O)[C@H](Nc1ccc3c(N)nccc3c1)c1ccc(c(C)c1)CCOC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7259,ML00009087,,,CO[C@H]1C[C@@H](C)O[C@@H](O[C@H]2[C@@H](C)/C=C\C(=O)O[C@@H](C)[C@@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)[C@@H]3O[C@@H]3/C=C\C(=O)[C@@](C)(O)C[C@H]2C)[C@@H]1O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009087_numbered.png,2026-03-19 06:58:02.483423
7260,ML00005488,,,CO[C@H]1[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O[C@H]2CC[C@H](N(C)C)[C@H](C)O2)[C@H](C)CC(CC=O)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005488_numbered.png,2026-03-19 06:58:02.536398
7261,ML00007654,,,C/C1=C/C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)[C@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)C(=O)CC1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 9, 10, 11, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00007654_numbered.png,2026-03-19 06:58:02.590821
7262,ML00003895,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@H]3[C@@H](OC)[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C\C=C/C(=O)[C@H](C)C[C@@H]3CCO)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003895_numbered.png,2026-03-19 06:58:02.642099
7263,ML00003775,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@H](C(C)=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@H](O)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003775_numbered.png,2026-03-19 06:58:02.692201
7264,ML00006558,,,CC[C@H]1OC(=O)C[C@@H](OC(C)=O)C(C)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](C=O)C[C@@H](C)[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)/C=C\C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006558_numbered.png,2026-03-19 06:58:02.751429
7265,ML00007595,,,C/C(=C\c1csc(C)n1)[C@@H]1C/C=C\C=C\C[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007595_numbered.png,2026-03-19 06:58:02.800021
7266,ML00006598,,,CC[C@H]1C[C@@H](C)C(=O)/C=C\C(C)=C/[C@H](C)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006598_numbered.png,2026-03-19 06:58:02.849104
7267,ML00008977,,,CO/C1=C/C(C)=C\[C@@H](C)[C@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00008977_numbered.png,2026-03-19 06:58:02.900873
7268,ML00001415,CHEMBL333491,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)C3(CCCC3)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7269,ML00009228,,,CC(C)C[C@@H]1OC(=O)[C@H](C)CNC(=O)[C@@H](Cc2cc(Cl)c(O)c(Cl)c2)NC(=O)/C=C\C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7270,ML00007380,,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)C(=O)O)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00007380_numbered.png,2026-03-19 06:58:02.970754
7271,ML00003739,,,CCC(=O)O[C@@H]1[C@@H](OC)C[C@@H](C)O[C@@H]1O[C@@H]1[C@@H](C)/C=C\C(=O)O[C@H](C)[C@@H](CO[C@H]2O[C@H](C)[C@H](O)[C@H](OC)[C@@H]2OC)[C@@H]2O[C@@H]2/C=C\C(=O)[C@](C)(O)C[C@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00003739_numbered.png,2026-03-19 06:58:03.029483
7272,ML00009321,,,COc1ccc(C[C@H]2NC(=O)/C=C\C[C@@H]([C@H](C)/C=C/c3ccccc3)OC(=O)[C@H](C(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7273,ML00009326,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(=O)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7274,ML00005545,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOS(=O)c2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005545_numbered.png,2026-03-19 06:58:03.099703
7275,ML00010081,,,C=CC[C@H]1C(=O)C(C)(C)[C@@H](O)CC(=O)O[C@H](c2ccc3sc(C)nc3c2)C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00010081_numbered.png,2026-03-19 06:58:03.150341
7276,ML00005928,,,CO/C1=C/C(C)=C\[C@@H](C)[C@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@]2(OC)C[C@@H](OC(=O)/C=C/C(=O)OCC3=CCC(=O)N3)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00005928_numbered.png,2026-03-19 06:58:03.199267
7277,ML00004817,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](C/C=C/c4ccc5ccccc5c4)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7278,ML00007507,,,C/C(=C\c1csc(C)n1)[C@@H]1C/C=C\CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,7.0,"[3, 10, 11, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00007507_numbered.png,2026-03-19 06:58:03.250432
7279,ML00005558,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005558_numbered.png,2026-03-19 06:58:03.304350
7280,ML00009640,,,CC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](C)C[C@@H](C)C(=O)/C=C\C=C/[C@@H]1CO[C@H]1O[C@@H](C)[C@H](O)[C@@H](OC)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009640_numbered.png,2026-03-19 06:58:03.350124
7281,ML00005559,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCSc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005559_numbered.png,2026-03-19 06:58:03.403234
7282,ML00003723,,,CCC[C@H]1OC(=O)[C@H](CC)[C@H]2CC[C@H](O2)[C@H](C)[C@@H]([C@@H](CC)[C@@H]2CC[C@H](C[C@@H](CCC)N(C)C)O2)OC(=O)[C@@H](C)[C@H]2CC[C@H](O2)[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7283,ML00008203,,,C[C@@H]1CCC(=O)/C=C/C(=O)O[C@H](C)CCC(=O)/C=C/C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7284,ML00004906,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCc4ccccc4)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004906_numbered.png,2026-03-19 06:58:03.470378
7285,ML00002556,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CCCCC2)C[C@@H](C)C(=O)C=CC(C)=C[C@@H]1CN1CCCCC1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002556_numbered.png,2026-03-19 06:58:03.523181
7286,ML00007381,,,C/C=C/CC[C@@H]1C/C=C(/C)[C@@H](O)C(C)(C)C(=O)[C@@H](C)/C=C(/C)[C@@H]2C[C@H](O)C[C@](O)(CC(=O)O1)O2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7287,ML00001394,CHEMBL122051,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)C3(CCCCC3)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7288,ML00010179,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](c3cccc([N+](=O)[O-])c3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7289,ML00001964,CHEMBL89807,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccc(N)cc2)NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7290,ML00006319,,,C[C@H]1C[C@H]2C(=O)OC[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)/C=C/C=C/C=C/C=C/C=C/C(=O)NC3=C(O)CCC3=O)C(=O)N3CCC[C@@H]3C(=O)N(C)[C@H](C)C(=O)N[C@H](C)C(=O)N2C1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7291,ML00001253,CHEMBL262809,,CCCC1(CCC)CNC(=O)[C@@H](Cc2ccc(OC)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7292,ML00002751,,,CO[C@H]1[C@H](OC)CO[C@@H](O[C@H]2C[C@H]3C[C@@H]([C@H]4C[C@@H]4C)OC(=O)C[C@@H]4O[C@@H](C[C@H](O[C@@H]5OC[C@@H](OC)[C@H](OC)[C@H]5OC)[C@H]4C)C[C@@H]([C@H]4C[C@@H]4C)OC(=O)C[C@@H](C2)O3)[C@@H]1OC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7293,ML00010373,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@]5([C@H](C)O)OCC/C(=C/C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)[C@@H]5O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7294,ML00004393,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc(OC(C)=O)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004393_numbered.png,2026-03-19 06:58:03.634005
7295,ML00001150,CHEMBL3895397,,COC[C@H](C)S(=O)(=O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1ccc3c(N)ncc(F)c3c1)c1ccc(c(C)c1)[C@@H](C)COC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7296,ML00009219,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@H]2O)[C@@H](C/C=N/NC(C)=O)C[C@@H](C)C(=O)/C=C\[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009219_numbered.png,2026-03-19 06:58:03.693434
7297,ML00009068,,,CCCC(=O)O[C@H]1[C@H](O[C@H]2[C@@H](C)[C@H](O)CC(=O)O[C@H](CC)[C@@H](C)[C@@H]3O[C@@]3(C)/C=C/C(=O)[C@H](C)C[C@@H]2CC=O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009068_numbered.png,2026-03-19 06:58:03.744518
7298,ML00000259,CHEMBL1552529,,CO[C@@H]1COC(=O)C/C=C\[C@@H](C)[C@H](OC)COC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7299,ML00009139,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(Br)C#Cc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7300,ML00009086,,,CO[C@H]1C[C@@H](C)O[C@@H](O[C@H]2[C@@H](C)/C=C\C(=O)O[C@@H](C)[C@@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)[C@@H]3O[C@H]3/C=C\C(=O)[C@](C)(O)C[C@H]2C)[C@@H]1O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009086_numbered.png,2026-03-19 06:58:03.806391
7301,ML00001979,CHEMBL122085,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)C3(CC3)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7302,ML00007682,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 6, 10, 11, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00007682_numbered.png,2026-03-19 06:58:03.858840
7303,ML00003225,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=N\OCC#Cc2cnc3ccccc3c2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003225_numbered.png,2026-03-19 06:58:03.911452
7304,ML00006381,,,CCC1OC(=O)CC(O)C(C)[C@@H](O[C@@H]2OC(C)[C@H](O[C@@H]3C[C@@](C)(O)C(O)C(C)O3)C(N(C)C)C2O)[C@H](CC=O)CC(C)C(=O)/C=C/C(C)=C/[C@@H]1COC1OC(C)C(O)C(OC)[C@@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006381_numbered.png,2026-03-19 06:58:03.965598
7305,ML00009225,,,CO[C@@H](C)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)C/C=C/C[C@H](C)[C@@H]1C/C=C\CC/C=C\[C@@H](O)[C@H](C)/C=C(C)\C=C(\C)C(=O)O1,standard_macrolactone,16.0,,,success,,5.0,"[3, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009225_numbered.png,2026-03-19 06:58:04.001204
7306,ML00006860,,,Cc1ccc(C)c(/N=C2/N=NC3(CCCCCCCCCCC(=O)OCCC3)S2)c1,standard_macrolactone,16.0,,,success,,0.0,[],ring_size_16/standard/numbered/ML00006860_numbered.png,2026-03-19 06:58:04.020131
7307,ML00006708,,,O=C1CCCCCCCCCC/C(=N/OC(=O)COc2ccc(Cl)cc2)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006708_numbered.png,2026-03-19 06:58:04.041427
7308,ML00006919,,,O=C1CCCCCCCCCCC(NS(=O)(=O)c2ccccc2[N+](=O)[O-])CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006919_numbered.png,2026-03-19 06:58:04.064506
7309,ML00003781,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003781_numbered.png,2026-03-19 06:58:04.117247
7310,ML00000630,CHEMBL3317815,,C[C@@]12CSC(=N1)c1csc(n1)CNC(=O)C[C@@H](/C=C/CCS)OC(=O)[C@H](CCCN)NC2=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7311,ML00007509,,,C/C(=C\c1csc(C)n1)[C@@H]1C/C=C/CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,7.0,"[3, 10, 11, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00007509_numbered.png,2026-03-19 06:58:04.165601
7312,ML00003773,,,CCC(=O)O[C@H]1CC(=O)O[C@H](C)C[C@@H]2O[C@@H]2/C=C\[C@H](O)[C@@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](O)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003773_numbered.png,2026-03-19 06:58:04.213446
7313,ML00002675,,,CCCC(=O)O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002675_numbered.png,2026-03-19 06:58:04.259562
7314,ML00002665,,,CCC(=O)O[C@H]1CC(=O)O[C@H](C)C[C@@H]2O[C@@H]2/C=C\[C@H](O)[C@@H](C)C[C@H](CC=O)[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@](C)(O)[C@@H](OC(=O)CC)[C@@H](C)O3)[C@@H](C)O2)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002665_numbered.png,2026-03-19 06:58:04.306756
7315,ML00000359,CHEMBL261834,3-DEOXY-EPO A,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)CCC(=O)O1,standard_macrolactone,16.0,,,success,,7.0,"[3, 10, 11, 12, 13, 14, 14]",ring_size_16/standard/numbered/ML00000359_numbered.png,2026-03-19 06:58:04.348889
7316,ML00010766,,,CCCCCCCCCCCC[C@@H]1CCCCCCCCC(=O)OC[C@H]2O[C@@H](O1)[C@H](O)[C@@H](OC(C)=O)[C@@H]2O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7317,ML00005091,,,C/C=C(\NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCN1C(=O)/C(=C/C)NC(=O)CC(O)CCCCC)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@H](CCN)C(=O)N[C@@H](CCCCN)C(=O)O[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7318,ML00002015,CHEMBL314522,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7319,ML00009463,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(C)CCN(C)C)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009463_numbered.png,2026-03-19 06:58:04.429692
7320,ML00000365,CHEMBL4061025,,C/C=C1\NC(=O)[C@H](CS)NC(=O)[C@@H](C(C)C)NC(=O)C[C@@H](/C=C/CS)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7321,ML00009420,,,CO[C@H]1[C@H](OC[C@H]2[C@@H]3O[C@@H]3/C=C\C(=O)[C@H](C)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@@]4(OC(=O)O[C@H]4C)[C@H]3O)[C@@H](C)/C=C\C(=O)O[C@@H]2C)O[C@H](C)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009420_numbered.png,2026-03-19 06:58:04.481391
7322,ML00001666,CHEMBL3251864,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](OC(=O)C(C)C)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001666_numbered.png,2026-03-19 06:58:04.527836
7323,ML00005789,,,CCCC(=O)O[C@@H]1CC(=O)O[C@H](C)C[C@@H](O)/C=C\C=C/[C@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](OC(=O)CC(C)C)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 5, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005789_numbered.png,2026-03-19 06:58:04.573571
7324,ML00007695,,,Cc1nc(/C=C(\CO)[C@@H]2C/C=C\CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O2)cs1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007695_numbered.png,2026-03-19 06:58:04.617994
7325,ML00003540,,,CC=C=C/C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@@H](C)N(C)C(=O)[C@@H]2CC[C@@H](CC)N2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7326,ML00004455,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCOS(=O)(=O)c2ccc(C)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004455_numbered.png,2026-03-19 06:58:04.680705
7327,ML00004238,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@@]2(OC)C[C@@H](OC(=O)/C=C/C(=O)O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00004238_numbered.png,2026-03-19 06:58:04.732244
7328,ML00002314,,,CO[C@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@@H]3C[C@](C)(O)[C@H](OC(=O)CC(C)C)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C\[C@H]2O[C@H]2C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002314_numbered.png,2026-03-19 06:58:04.778440
7329,ML00002545,,,CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H]1C(=O)N2CCC[C@H]2C(=O)N2CC[C@H](C)C[C@H]2C(=O)N[C@@H](C)C(=O)N2C[C@H](C)C[C@H]2C(=O)O[C@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7330,ML00008829,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H]3O[C@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7331,ML00001416,CHEMBL102573,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c3ccc(C)c(C)c3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7332,ML00004448,,,CC[C@H]1OC(=O)C[C@@H](OC(C)=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004448_numbered.png,2026-03-19 06:58:04.854735
7333,ML00010953,,,CCC1OC(=O)CC(O)C(C)C(O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)C(CC=O)CC(C)C(=O)/C=C/C(C)=C/C1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010953_numbered.png,2026-03-19 06:58:04.905045
7334,ML00007675,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H](O)[C@H](O)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)C(O)CC(=O)O1,standard_macrolactone,16.0,,,success,,10.0,"[3, 5, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007675_numbered.png,2026-03-19 06:58:04.956360
7335,ML00003545,,,C/C=C/C=C/C=C\C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7336,ML00010567,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCO)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010567_numbered.png,2026-03-19 06:58:05.016952
7337,ML00005677,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc(C=O)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005677_numbered.png,2026-03-19 06:58:05.073293
7338,ML00009526,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CCCCCC2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009526_numbered.png,2026-03-19 06:58:05.126350
7339,ML00007488,,,C/C1=C/[C@H](C)CC[C@@H](C)OC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)CC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7340,ML00004263,,,C/C=C1\NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(C)CC(C)CC(C)CCC)C(C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7341,ML00004471,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOC2NNC(c3ccccc3)C(c3ccccc3)N2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004471_numbered.png,2026-03-19 06:58:05.199252
7342,ML00007692,,,C/C(=C\c1csc(CO)n1)[C@@H]1C[C@H]2O[C@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007692_numbered.png,2026-03-19 06:58:05.246249
7343,ML00009360,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@@](C)(O)/C=C\c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7344,ML00001662,CHEMBL3244604,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2OC(=O)CCC(=O)O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001662_numbered.png,2026-03-19 06:58:05.301197
7345,ML00010167,,,CC(C)=C/C=C/[C@@H](C)C/C=C/[C@@H](C)[C@@H]1C/C=C\[C@@H](O)[C@@H](O)[C@@H](O)C[C@@H](C)[C@@H](O)C[C@@H](O)CCC(=O)O1,standard_macrolactone,16.0,,,success,,7.0,"[3, 7, 8, 9, 11, 12, 14]",ring_size_16/standard/numbered/ML00010167_numbered.png,2026-03-19 06:58:05.343996
7346,ML00004604,,,CCC(=O)O[C@@H]1CC(=O)O[C@@H](C/C=C/c2cnc3ccccc3c2)CCCN(C)C[C@H](O)[C@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(OC(=O)CC)[C@@H](OC(=O)NC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H]1OC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7347,ML00005981,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN(C)CCN(C)C)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005981_numbered.png,2026-03-19 06:58:05.410352
7348,ML00004474,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ncnc3ccccc23)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004474_numbered.png,2026-03-19 06:58:05.467486
7349,ML00004260,,,CO/C1=C/C(C)=C\[C@@H](C)[C@H](OC(C)=O)[C@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@@]2(OC)C[C@@H](OC(C)=O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00004260_numbered.png,2026-03-19 06:58:05.520286
7350,ML00001026,CHEMBL3334620,,CC(C)[C@@H]1C[C@H](O)[C@H](C)C[C@H](C)C[C@H](C)C(=O)NCC(=O)N(C)[C@H](Cc2ccc(O)c(I)c2)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7351,ML00008830,,,COc1ccc(CC2NC(=O)/C=C/CC(C(C)C3OC3c3ccccc3)OC(=O)C(CC(C)C)OC(=O)C(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7352,ML00003388,,,CCCC(=O)O[C@@H]1[C@@H](C)O[C@@H](O[C@H]2[C@H](C)O[C@H](O[C@H]3[C@@H](OC)[C@@H](O)CC(=O)O[C@@H](C)C/C=C\C=C/[C@@H](O)[C@@H](C)C[C@@H]3CC=O)[C@@H](O)[C@@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003388_numbered.png,2026-03-19 06:58:05.585209
7353,ML00000371,CHEMBL393360,,CC(C)[C@H]1NC(=O)[C@H]2CSSCC/C=C/[C@H](CC(=O)N[C@H](C)C(=O)N2)OC(=O)CNC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7354,ML00009847,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009847_numbered.png,2026-03-19 06:58:05.644031
7355,ML00010562,,,CC[C@H]1C[C@@H](C)C(=O)/C=C\[C@]2(C)O[C@H]2[C@H](C)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@H]1O[C@H](C)C[C@@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010562_numbered.png,2026-03-19 06:58:05.699385
7356,ML00002326,,,COC1C(OC(C)=O)CC(=O)OC(C)C/C=C/C=C\C(O)C(C)CC(CC=O)C1OC1OC(C)C(OC2CC(C)(O)C(OC(=O)CC(C)C)C(C)O2)C(N(C)C)C1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002326_numbered.png,2026-03-19 06:58:05.750112
7357,ML00000253,CHEMBL214209,,CN1C2CCC1C1COC(=O)CCCCCC(=O)Nc3ccc(cc3)C1C2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7358,ML00008885,,,CCC[C@H]1C[C@@H]2CC[C@@H](O2)[C@H](C)C(=O)O[C@@H]([C@H](C)[C@H]2CC[C@@H](C[C@@H](CCC)NC)O2)[C@H](C)[C@@H]2CC[C@@H](O2)[C@@H](C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7359,ML00001180,CHEMBL400438,,CN(c1cc2cc(c1)C(=O)N[C@@H](c1ccccc1)CCc1cccc(c1)C[C@@](C)(N)C(=O)OC2)S(C)(=O)=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7360,ML00000609,CHEMBL3410860,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](c3ccc(Cl)cc3Cl)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7361,ML00004850,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)OCCC(/C=C\Cc4cnc5ccccc5c4)CN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7362,ML00009363,,,COc1ccc(C[C@H]2NC(=O)/C=C\C[C@@H]([C@@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7363,ML00007520,,,Cc1cc(OC(C)C(=O)ON=C2CCCCCCCCCCC(=O)OCCC2)ccc1Cl,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00007520_numbered.png,2026-03-19 06:58:05.818635
7364,ML00001023,CHEMBL1173194,,CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)C2=N[C@@H](CS2)C(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7365,ML00006922,,,O=C1CCCCCCCCCCC(NS(=O)(=O)c2ccccc2Cl)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006922_numbered.png,2026-03-19 06:58:05.848888
7366,ML00003058,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=O)/C=C/C=C/[C@@H]1COC1CCOCC1,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003058_numbered.png,2026-03-19 06:58:05.900453
7367,ML00009067,,,CCCC(=O)O[C@@H]1[C@@H](O[C@@H]2[C@@H](C)[C@H](O)CC(=O)O[C@H](CC)[C@@H](C)[C@@H]3O[C@@]3(C)/C=C\C(=O)[C@H](C)C[C@@H]2CC=O)O[C@@H](C)C[C@H]1N(C)C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009067_numbered.png,2026-03-19 06:58:05.952869
7368,ML00000086,CHEMBL4078721,,CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCSCCS)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7369,ML00002264,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccc(COC(=O)C(C)(C)CN)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7370,ML00007521,,,Cc1cc(OCC(=O)ON=C2CCCCCCCCCCC(=O)OC(C)CC2)ccc1Cl,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/ML00007521_numbered.png,2026-03-19 06:58:05.997678
7371,ML00001414,CHEMBL406057,,COC(=O)c1ccc([C@H](Cl)[C@H](O)[C@@H](C)[C@@H]2C/C=C/C(=O)N[C@H](Cc3ccc(OC)c(Cl)c3)C(=O)NCC(C)(C)C(=O)O[C@@H](CC(C)C)C(=O)O2)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7372,ML00009138,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(=O)C#Cc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7373,ML00002287,,,CO[C@@H]1[C@@H](OC2OC(C)C(OC3CC(C)(O)C(OC(=O)CC(C)C)C(C)O3)C(N(C)C)C2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\C2O[C@H]2C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002287_numbered.png,2026-03-19 06:58:06.062409
7374,ML00008913,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](CC)[C@H](C)[C@@H]2O[C@]2(C)/C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00008913_numbered.png,2026-03-19 06:58:06.118790
7375,ML00007029,,,O=C1CCCCCCCCCCC2(CCCO1)N=N/C(=N/c1ccccc1Cl)S2,standard_macrolactone,16.0,,,success,,0.0,[],ring_size_16/standard/numbered/ML00007029_numbered.png,2026-03-19 06:58:06.138697
7376,ML00000128,CHEMBL3930523,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(C(=O)N(C)C)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7377,ML00004585,,,CC(C)CCCCCCC(O)CC(=O)NC(CS(=O)(=O)O)C(=O)NC(CC(C)C)C(=O)NCCCC(=O)NC(Cc1cnc[nH]1)C(=O)NC(C)C(=O)NC1C(=O)NC(C(C)O)C(=O)NC(Cc2cnc[nH]2)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)OC1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7378,ML00004865,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@@H]4OC(=O)N(CCc5ccccc5)[C@@H]4/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004865_numbered.png,2026-03-19 06:58:06.203508
7379,ML00001159,CHEMBL1171465,,CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)C2=N[C@@](CC)(CS2)C(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7380,ML00005886,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC(=O)/C=C/C(=O)NC3=C(O)CCC3=O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00005886_numbered.png,2026-03-19 06:58:06.262832
7381,ML00001661,CHEMBL3244605,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](OC(=O)CCC(=O)O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001661_numbered.png,2026-03-19 06:58:06.309976
7382,ML00002839,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](OC(=O)/C=C/c3ccnc4ccccc34)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](OC(C)=O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002839_numbered.png,2026-03-19 06:58:06.355947
7383,ML00006321,,,CC1CC2C(=O)OCC(NC(=O)C(Cc3ccccc3)NC(=O)/C=C\C=C\C=C\C=C\C=C/C(=O)NC3=C(O)CCC3=O)C(=O)N3CCCC3C(=O)N(C)C(C)C(=O)NC(C)C(=O)N2C1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7384,ML00006318,,,C[C@@H]1NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)/C=C/C=C/C=C/C=C/C=C/C(=O)NC2=C(O)CCC2=O)COC(=O)[C@@H]2C[C@@H](C)CN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7385,ML00006742,,,NC(=O)c1cccc(NC2C(=O)NCc3cccc(c3)NC(=O)OCCc3ccc2cc3)c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7386,ML00001819,CHEMBL103264,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c3ccc(O)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7387,ML00003389,,,CCCC(=O)O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003389_numbered.png,2026-03-19 06:58:06.427821
7388,ML00000767,CHEMBL1305053,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)CC=CC=C[C@@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00000767_numbered.png,2026-03-19 06:58:06.473154
7389,ML00001970,CHEMBL432373,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](CC2CCCCC2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7390,ML00000361,CHEMBL3317817,,CC(C)(C)OC(=O)NCCC[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCS)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7391,ML00000200,CHEMBL316640,CRYPTOPHYCIN 52,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7392,ML00002383,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=O)/C=C/C=C/[C@@H]1CSc1ccccn1,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002383_numbered.png,2026-03-19 06:58:06.539694
7393,ML00000821,CHEMBL4113473,,CCN(Cc1nccs1)C(=O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1ccc3c(N)nccc3c1)c1cc(C)c(c(C)c1)C(F)(F)COC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7394,ML00005481,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CCCCCCC2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005481_numbered.png,2026-03-19 06:58:06.599370
7395,ML00008831,,,CC[C@H](C)[C@@H]1OC(=O)[C@H](C)CNC(=O)[C@@H](Cc2ccc(OC)c(Cl)c2)NC(=O)/C=C\C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7396,ML00008042,,,O=C1CCCCCCCCCCCNCCO1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7397,ML00006831,,,C/C=C1\NC(=O)C2CSSCCC=CC(CC(=O)NC(C(C)C)C(=O)N2)OC(=O)C(C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7398,ML00009304,,,COc1ccc(C[C@H]2NC(=O)/C=C\C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7399,ML00002620,,,CCCC(=O)OC1C(C)OC(OC2C(C)OC(OC3C(CC=O)CC(C)C(=O)/C=C\C4OC4CC(C)OC(=O)CC(OC(C)=O)C3OC)C(O)C2N(C)C)CC1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002620_numbered.png,2026-03-19 06:58:06.667366
7400,ML00001031,CHEMBL2093007,,C/C=C1\NC(=O)[C@@H](CSC)NC(=O)[C@@H](C(C)C)CC(=O)C[C@@H](/C=C/CCSC)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7401,ML00010637,,,CC(C)C[C@@H]1OC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7402,ML00005235,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=N\OCCCOc2ccc3ncccc3c2)/C=C/C(C)=C/C1CO[C@@H]1C[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005235_numbered.png,2026-03-19 06:58:06.733732
7403,ML00003682,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCO)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003682_numbered.png,2026-03-19 06:58:06.786061
7404,ML00004245,,,CCCC/C=C/C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](CC)NC(=O)[C@@H]2CCCCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7405,ML00009271,,,CC[C@H](O)[C@@H](C)/C=C/C(=O)[C@H](C)[C@H](O)[C@H](C)[C@H]1OC(=O)/C(C)=C\C(C)=C/[C@H](C)[C@@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009271_numbered.png,2026-03-19 06:58:06.837811
7406,ML00002697,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/C(=O)[C@H](C)C[C@H](CC=O)[C@@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](OC(=O)CC(C)C)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002697_numbered.png,2026-03-19 06:58:06.885330
7407,ML00001924,CHEMBL399362,,C[C@@]1(N)Cc2cccc(c2)CC[C@H](c2ccc(F)cc2)NC(=O)c2cc(cc(-c3cccc(F)c3C#N)c2)COC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7408,ML00007786,,,CO[C@H]1CC(=O)[C@@H](C)OC(=O)C[C@H](C)OC(=O)/C=C\[C@@H](O)[C@H](C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7409,ML00010915,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@H]2OCC[C@H]2C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 6, 9, 10, 14, 15]",ring_size_16/standard/numbered/ML00010915_numbered.png,2026-03-19 06:58:06.940101
7410,ML00010015,,,C=CC[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCSC(=O)CCCCCCC)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7411,ML00005822,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=N/OCCCCOc2ccc3ncccc3c2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005822_numbered.png,2026-03-19 06:58:06.997142
7412,ML00007144,,,C/C1=C/C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)C(=O)CC1,standard_macrolactone,16.0,,,success,,10.0,"[3, 6, 9, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007144_numbered.png,2026-03-19 06:58:07.048094
7413,ML00003248,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccc(CNCCN)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7414,ML00009200,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(C)C)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009200_numbered.png,2026-03-19 06:58:07.107227
7415,ML00001297,CHEMBL3244603,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(=O)C(Cl)Cl)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001297_numbered.png,2026-03-19 06:58:07.153983
7416,ML00010597,,,CN(C)[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@]23C=CC=C2c2c4ccc(c2Cl)[C@@H](O)COC(=O)C[C@H](N)c2cc(O)c(c(Cl)c2)O[C@H]43)OC1(C)C,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7417,ML00008863,,,CO[C@@H](/C(C)=C/C=C/C(C)=C/c1coc(C)n1)[C@@H](C)[C@@H]1C[C@H](O)/C(C)=C\C=C/[C@@H](C)[C@H]2C[C@@H](C/C=C\C(=O)O1)CC(=O)O2,standard_macrolactone,16.0,,,success,,4.0,"[3, 5, 6, 10]",ring_size_16/standard/numbered/ML00008863_numbered.png,2026-03-19 06:58:07.193423
7418,ML00008822,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7419,ML00001592,CHEMBL3251873,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001592_numbered.png,2026-03-19 06:58:07.246269
7420,ML00002294,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/[C@@H]2O[C@H]2C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002294_numbered.png,2026-03-19 06:58:07.293010
7421,ML00010560,,,CC[C@H]1C[C@@H](C)C(=O)/C=C\C(C)=C/[C@H](C)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@H]1O[C@H](C)C[C@H](N(C)C)[C@@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010560_numbered.png,2026-03-19 06:58:07.343812
7422,ML00009332,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(C#Cc3ccccc3)OS(C)(=O)=O)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7423,ML00001561,CHEMBL3251861,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](OC(C)=O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001561_numbered.png,2026-03-19 06:58:07.396677
7424,ML00002289,,,CO[C@H]1[C@H](OC(C)=O)CC(=O)O[C@H](C)C[C@@H]2O[C@@H]2/C=C\C(=O)[C@H](C)C[C@H](CC=O)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O2)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002289_numbered.png,2026-03-19 06:58:07.442256
7425,ML00003507,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCNCCc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003507_numbered.png,2026-03-19 06:58:07.492857
7426,ML00001997,CHEMBL4061758,,CC[C@@H]1OC(=O)C[C@@H](C/C=C/C=C(\C)[C@H]2OC(=O)CC/C=C(\C)[C@@H](C)[C@H](O)[C@H](C)[C@@H](OC(N)=O)/C=C\C=C/[C@@H]2C)[C@H]1C,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 11, 12, 13]",ring_size_16/standard/numbered/ML00001997_numbered.png,2026-03-19 06:58:07.534461
7427,ML00002906,,,CC[C@H]1C[C@@H](C)[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)/C=C\C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@H](OC)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002906_numbered.png,2026-03-19 06:58:07.582514
7428,ML00004847,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](C/C=C/c4cnc5ccccc5c4)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7429,ML00001039,CHEMBL235300,,CC(=O)SCC/C=C/[C@@H]1CC(=O)N[C@H](C)C(=O)N[C@H](C)C(=O)N[C@H](C(C)C)C(=O)NCC(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7430,ML00009641,,,CC[C@@H]1OC(=O)/C=C\[C@H](C)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@H](C)C[C@@H](C)C(=O)/C=C\C=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009641_numbered.png,2026-03-19 06:58:07.640244
7431,ML00003312,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC(=O)NCCc1ccccc1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003312_numbered.png,2026-03-19 06:58:07.690769
7432,ML00003784,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003784_numbered.png,2026-03-19 06:58:07.742555
7433,ML00006801,,,CC(Oc1cccc(Cl)c1)C(=O)ON=C1CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006801_numbered.png,2026-03-19 06:58:07.765093
7434,ML00005379,,,CNc1c(C(=O)CNC2C(=O)NC(C(C)C)C(=O)N3CCCC3C(=O)N(C)CC(=O)N(C)C(C(C)C)C(O)OC2C)c2nc3c(C(=O)NC4C(=O)NC(C(C)C)C(=O)N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)cccc3oc-2c(C)c1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7435,ML00010152,,,CCC[C@H](O)CC[C@@H](C)[C@@H]1OC(=O)[C@H](C)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@]2(C)CSC(=N2)[C@H](C)NC(=O)C1(C)C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7436,ML00001426,CHEMBL3342324,,C/C=C/C=C/C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7437,ML00008232,,,C[C@H]1CC(=O)O[C@@H](C)[C@H](O)/C=C\C(=O)O[C@@H](C)[C@H](O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7438,ML00002330,,,CC[C@H]1OC(=O)C[C@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](C/C=C/C(=O)OC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002330_numbered.png,2026-03-19 06:58:07.843555
7439,ML00007273,,,C/C1=C/[C@H](C)CC[C@@H](C)OC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7440,ML00006670,,,O=C1CCCCCCCCCC/C(=N\OC(=O)COc2ccc(Br)cc2Cl)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006670_numbered.png,2026-03-19 06:58:07.871310
7441,ML00002012,CHEMBL162213,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)NC(=O)C[C@@H](C)NC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7442,ML00006245,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](C/C=C/c4ccccc4)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7443,ML00000599,CHEMBL3628318,,CC[C@H]1NC(=O)[C@@H](C(C)C)NC(=O)C[C@@H](/C=C/CCSC(C)=O)OC(=O)CNC(=O)[C@@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7444,ML00000652,CHEMBL3628314,,CC(C)[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)NCc1cc(Br)ccc1CC(=O)O2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7445,ML00006405,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(OC(C)=O)C(N(C)C(C)=O)C2OC(C)=O)[C@@H](CC(OC)OC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006405_numbered.png,2026-03-19 06:58:07.948058
7446,ML00003897,,,CCC(=O)O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@H](O[C@H]3[C@@H](OC)[C@@H](OC(C)=O)CC(=O)O[C@@H](C)C/C=C\C=C/[C@@H](O)[C@@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003897_numbered.png,2026-03-19 06:58:07.993188
7447,ML00001957,CHEMBL4066874,,CCOC(=O)C[C@H]1NC(=O)[C@H](Nc2ccc3cc[nH]c(=O)c3c2)c2cc(C)c(c(C)c2)CCOC(=O)Nc2cccc1c2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7448,ML00009266,,,CCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O)CC(=O)O[C@H](CC)[C@@H](C)[C@@H]3O[C@@]3(C)/C=C/C(=O)[C@H](C)C[C@@H]2CC=O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009266_numbered.png,2026-03-19 06:58:08.049953
7449,ML00003549,,,CC[C@@H](C)[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)/C=C/C=C/C=C/C=C/c2ccc(O)c(Br)c2)[C@@H](C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7450,ML00009382,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC(=O)Nc1ccc(Br)cc1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009382_numbered.png,2026-03-19 06:58:08.107365
7451,ML00005543,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=N\OCc2ccc(F)cc2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005543_numbered.png,2026-03-19 06:58:08.159479
7452,ML00001151,CHEMBL3920165,,COCCCOc1c(F)cc2cc1CN(C)C(=O)[C@H](Nc1ccc3c(N)nccc3c1)c1ccc(c(C)c1)[C@@H](C)COC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7453,ML00004374,,,CC[C@@H]1[C@@H](C)O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C=C\C=C/[C@@H](C)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]3(O)C[C@@H](O[C@H]4C[C@H](O)[C@H](O)[C@H](C)O4)[C@H](CC)[C@@H](C)O3)OC(=O)/C=C\C=C/[C@@H]2C)C[C@H]1O[C@H]1C[C@H](O)[C@H](O)[C@H](C)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7454,ML00000729,CHEMBL1437681,,CO[C@H]1COC(=O)[C@@H](OCc2ccccc2)/C=C\[C@H](C)[C@@H](OC)COC(=O)[C@H](OCc2ccccc2)/C=C\[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7455,ML00009522,,,CCC[C@@H]1OC(=O)[C@H](C)[C@H]2CC[C@H](O2)[C@@H](C)[C@H]([C@H](C)[C@H]2CC[C@@H](C[C@@H](CCC)N(C)C)O2)OC(=O)[C@@H](CC)[C@H]2CC[C@H](O2)[C@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7456,ML00007513,,,Cc1ccc(OCC(=O)ON=C2CCCCCCCCCCC(=O)OCCC2)cc1C,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00007513_numbered.png,2026-03-19 06:58:08.207598
7457,ML00009535,,,CCC1OC(=O)/C=C\C(C)C(OC2OC(C)C(O)C(N(C)C)C2O)C(C)CC(C)C(=O)CC/C=C\C1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009535_numbered.png,2026-03-19 06:58:08.250905
7458,ML00009083,,,CO[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)/C=C\C(=O)O[C@@H](C)[C@@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)[C@@H]3O[C@H]3/C=C\C(=O)[C@@](C)(O)C[C@@H]2C)[C@@H]1O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009083_numbered.png,2026-03-19 06:58:08.298400
7459,ML00006164,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](C/C=C/c4cccnc4)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7460,ML00009044,,,C#CCCCC1NC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(OC)cc2)N(C)C(=O)C(C(C)CC)OC(=O)C1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7461,ML00003728,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OCCC(N(C)C)C2O)[C@@H](CC=O)C[C@@H](C)C(=O)CCC(C)C[C@@H]1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003728_numbered.png,2026-03-19 06:58:08.363442
7462,ML00007268,,,CC1=C2Cc3cc(ccc3O)C(=O)O[C@H](C(C)(C)O)CC[C@]3(C)O[C@H]3C/C=C(\C)C2CC1,standard_macrolactone,16.0,,,success,,3.0,"[3, 6, 10]",ring_size_16/standard/numbered/ML00007268_numbered.png,2026-03-19 06:58:08.393997
7463,ML00008201,,,C[C@@H]1OC(=O)C[C@@H](C)OC(=O)/C=C\[C@H](O)[C@H](C)OC(=O)/C=C\C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7464,ML00010604,,,CCC[C@@H](CC[C@@H](C)[C@@H]1OC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)CCO)N(C)C(=O)[C@]2(C)CSC(=N2)[C@H](C)NC(=O)C1(C)C)OC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7465,ML00000063,CHEMBL343448,ROMIDEPSIN,C/C=C1\NC(=O)[C@H]2CSSCC/C=C/[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7466,ML00009853,,,CO[C@H]1[C@H](OC[C@H]2[C@@H]3O[C@H]3CCC(=O)[C@@](C)(O)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@](O)([C@H](C)O)[C@H]3O)[C@@H](C)/C=C/C(=O)O[C@@H]2C)O[C@H](C)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009853_numbered.png,2026-03-19 06:58:08.459429
7467,ML00006383,,,CC[C@H]1OC(=O)C[C@@H](O)[C@@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](O)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@H](CC=O)C[C@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO[C@H]1O[C@@H](C)[C@H](O)[C@@H](OC)[C@@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006383_numbered.png,2026-03-19 06:58:08.512843
7468,ML00001410,CHEMBL430656,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccc(CC(=O)O)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7469,ML00001420,CHEMBL104949,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H]3O[C@H]3c3cc(C)ccc3C)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7470,ML00003386,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003386_numbered.png,2026-03-19 06:58:08.578956
7471,ML00008238,,,C[C@H]1C/C=C\C(=O)O[C@@H](C)[C@H](O)/C=C\C(=O)O[C@H](C)CC(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7472,ML00004142,,,CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H]1C(=O)N2CCC[C@H]2C(=O)N2CCCC[C@H]2C(=O)N[C@@H](C)C(=O)N2C[C@H](C)C[C@H]2C(=O)O[C@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7473,ML00000671,CHEMBL3628305,,CC(C)[C@@H]1NC(=O)CC(=O)O[C@@H]2/C=C/CCSSC[C@@H](NC(=O)[C@@H](C(C)C)NC(=O)C2)C(=O)N1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7474,ML00006669,,,O=C1CCCCCCCCCCC(=NOC(=O)COc2ccc(Br)cc2Cl)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006669_numbered.png,2026-03-19 06:58:08.622504
7475,ML00001643,CHEMBL42743,TYLOSIN,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001643_numbered.png,2026-03-19 06:58:08.676727
7476,ML00006141,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(C)=O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006141_numbered.png,2026-03-19 06:58:08.732148
7477,ML00007185,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007185_numbered.png,2026-03-19 06:58:08.780594
7478,ML00008140,,,C[C@@H]1CCC(=O)CCC(=O)O[C@H](C)CC[C@H](O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7479,ML00010347,,,CC1=CC2OC3CC4OC(=O)/C=C/CCC5(C(C)O)OCCC6(OC6C(=O)OCC2(CC1)C4(C)C31CO1)C5O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7480,ML00010945,,,CCC1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/[C@]2(C)OC2C1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010945_numbered.png,2026-03-19 06:58:08.843942
7481,ML00004637,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCCc4ccccc4)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004637_numbered.png,2026-03-19 06:58:08.899343
7482,ML00003674,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(CCCN(C)C)C(C)=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003674_numbered.png,2026-03-19 06:58:08.952207
7483,ML00005828,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=N/OCCCCc2cnc3ccccc3c2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005828_numbered.png,2026-03-19 06:58:09.004152
7484,ML00007511,,,CC(C)(Oc1ccccc1)C(=O)ON=C1CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00007511_numbered.png,2026-03-19 06:58:09.028207
7485,ML00000835,CHEMBL86762,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7486,ML00004857,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](C/C=C/c4ccc5ncccc5c4)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7487,ML00003394,,,CO[C@@H]1[C@@H](OC(C)=O)CC(=O)O[C@@H](C)C/C=C\C=C/[C@H](O[C@@H]2C[C@H](N(C)C)C[C@@H](C)O2)[C@H](C)C[C@H](CC=O)[C@H]1O[C@H]1C[C@@H](C)[C@H](O)[C@@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003394_numbered.png,2026-03-19 06:58:09.095893
7488,ML00002668,,,CCC(=O)O[C@H]1CC(=O)O[C@@H](C)C/C(O)=C\C=C/C[C@@H](C)C[C@@H](CC=O)[C@H](O[C@H]2O[C@H](C)[C@@H](O[C@H]3C[C@](C)(O)[C@H](OC(=O)CC)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 5, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002668_numbered.png,2026-03-19 06:58:09.151922
7489,ML00008234,,,C[C@H]1CC(=O)O[C@H](C)[C@@H](O)/C=C\C(=O)O[C@H](C)[C@@H](O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7490,ML00003149,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=N\OCCCOc2ccc3ncccc3c2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003149_numbered.png,2026-03-19 06:58:09.213851
7491,ML00001121,CHEMBL3907868,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(S(=O)(=O)C(C)C)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)ncc(F)c2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7492,ML00009330,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(O)C#Cc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7493,ML00008867,,,C/C=C/C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7494,ML00002123,CHEMBL4104519,,Cc1cc2cc(C)c1CCOC(=O)Nc1cccc(c1)CN(C)C(=O)C2Nc1ccc2cc[nH]c(=O)c2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7495,ML00000403,CHEMBL3410862,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](c3ccc(Br)cc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7496,ML00010398,,,C[C@]1(O)CC[C@]23COC(=O)/C=C4/CCO[C@@](C(=O)CO)(CC/C=C\C(=O)O[C@@H]5C[C@H]6O[C@@H]2[C@@H]1C[C@@]6(O)[C@]53C)[C@@H]4O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7497,ML00004625,,,CCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](C/C=C/c4ccc5ccccc5c4)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(=O)CC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7498,ML00000831,CHEMBL554607,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2OC(c3ccc(C(C)C)cc3)=N[C@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00000831_numbered.png,2026-03-19 06:58:09.312232
7499,ML00002173,,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](C(=O)Oc3ccccc3)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00002173_numbered.png,2026-03-19 06:58:09.362163
7500,ML00005653,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCNCCc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005653_numbered.png,2026-03-19 06:58:09.423048
7501,ML00002493,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccc(OC(=O)C(C)(C)CN)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7502,ML00008957,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CCOCC2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00008957_numbered.png,2026-03-19 06:58:09.490780
7503,ML00003531,,,CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](CC)NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7504,ML00005544,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005544_numbered.png,2026-03-19 06:58:09.559680
7505,ML00005708,,,C[C@@H]1NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)/C=C/C=C/C=C/C=C/C=C/C(=O)NC2=C(O)CCC2=O)COC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7506,ML00010791,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](C)C[C@H](C)C(=O)/C=C\[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010791_numbered.png,2026-03-19 06:58:09.619555
7507,ML00002310,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(OC(=O)CC(C)C)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)C=CC=CC[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002310_numbered.png,2026-03-19 06:58:09.666738
7508,ML00005533,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN(C)CCCN(C)C)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005533_numbered.png,2026-03-19 06:58:09.719979
7509,ML00001027,CHEMBL3092472,,CC[C@@H]1/C=C/[C@H](C(C)O)OC(=O)/C(C)=C\[C@H]2C(=O)NC3=CC(=O)c4c(cc(C)c(O)c4C(=O)CC1)[C@@]32O,standard_macrolactone,16.0,,,success,,5.0,"[3, 6, 9, 13, 16]",ring_size_16/standard/numbered/ML00001027_numbered.png,2026-03-19 06:58:09.757925
7510,ML00002038,CHEMBL2425896,,C/C1=C/C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C)CC1,standard_macrolactone,16.0,,,success,,10.0,"[3, 6, 9, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00002038_numbered.png,2026-03-19 06:58:09.810292
7511,ML00002925,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@@H]3C[C@](C)(O)[C@H](O)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O[C@H]2CC[C@H](N(C)C)[C@H](C)O2)/C=C/C=C/C[C@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002925_numbered.png,2026-03-19 06:58:09.858011
7512,ML00009974,,,CC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](C)C[C@@H](C)C(=O)/C=C\C=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009974_numbered.png,2026-03-19 06:58:09.902652
7513,ML00009536,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@H](O[C@H]2O[C@@H](C)[C@H](O[C@@H]3CC[C@@H](O)[C@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@H](CCO)C[C@H](C)C(=O)/C=C\[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009536_numbered.png,2026-03-19 06:58:09.956490
7514,ML00006959,,,CC[C@H]1C[C@@H](C)C(=O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@H](OC)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006959_numbered.png,2026-03-19 06:58:09.999026
7515,ML00009331,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](CC#Cc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7516,ML00004396,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCCn4cnc(-c5cccnc5)c4)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004396_numbered.png,2026-03-19 06:58:10.061701
7517,ML00006384,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006384_numbered.png,2026-03-19 06:58:10.130878
7518,ML00004852,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)OCCC(/C=C/Cc4ccnc5ccccc45)CN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7519,ML00009596,,,CO[C@H]1[C@@H](O[C@H]2O[C@@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@@H](C)O3)[C@H](N(C)C)[C@@H]2O)[C@H](CC=O)C[C@H](C)C(=O)/C=C\[C@H]2O[C@@H]2C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009596_numbered.png,2026-03-19 06:58:10.187310
7520,ML00003526,,,CO[C@H]1/C=C\C(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(C)=O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](OC(=O)Nc2ccc(C(F)(F)F)cc2)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,6.0,"[3, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00003526_numbered.png,2026-03-19 06:58:10.231671
7521,ML00000735,CHEMBL3926417,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(C(N)=O)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7522,ML00008970,,,CO[C@@H]1C(O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)C(CC=O)C[C@@H](C)[C@@H](O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00008970_numbered.png,2026-03-19 06:58:10.284525
7523,ML00008235,,,C[C@H]1CC(=O)O[C@@H](C)[C@H](O)/C=C/C(=O)O[C@@H](C)[C@H](O)/C=C/C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7524,ML00002195,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)/C(C)=C/C)C(C)C)[C@@H](C)OC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(=O)OC)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7525,ML00003397,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCBr)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003397_numbered.png,2026-03-19 06:58:10.353638
7526,ML00008136,,,C[C@@H]1CC[C@H](O)/C=C\C(=O)O[C@H](C)CC[C@H](O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7527,ML00005810,,,CO[C@H]1[C@H](OC)CO[C@@H](O[C@H]2C[C@H]3C[C@@H]([C@H]4C[C@@H]4C)OC(=O)C[C@@H]4O[C@@H](C[C@H](O[C@@H]5OC[C@@H](OC)[C@H](OC)[C@H]5OC)[C@H]4C)C[C@@H]([C@H]4C[C@@H]4C)OC(=O)C[C@H](O3)[C@@H]2C)[C@@H]1OC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7528,ML00003272,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccc(COC(=O)CN)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7529,ML00001423,CHEMBL103389,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccc(C)c(C)c3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7530,ML00007067,,,CC(C)[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)N1CCC(CC1)CC(=O)O2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7531,ML00010565,,,CC[C@H]1OC(=O)C[C@@H](O)[C@@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](CCO)C[C@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010565_numbered.png,2026-03-19 06:58:10.445756
7532,ML00000380,CHEMBL3809352,,C[C@@H]1COC(=O)Nc2cccc(c2)CNC(=O)C(Nc2ccc3c(N)nccc3c2)c2ccc1cc2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7533,ML00000171,CHEMBL194251,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2C[C@@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)CCC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 6, 10, 11, 12, 13, 14, 14]",ring_size_16/standard/numbered/ML00000171_numbered.png,2026-03-19 06:58:10.504054
7534,ML00009917,,,CO[C@@H]1C[C@H](OC(N)=O)[C@@H]2C=C[C@@H]3/C=C(C)/C=C/[C@@H](C)[C@H]([C@H](C)[C@H](O)[C@@H](C)NC(C)=O)OC(=O)/C=C/C=C(C)\C=C\[C@]3(C)[C@@H]2C1,standard_macrolactone,16.0,,,success,,5.0,"[3, 4, 7, 10, 13]",ring_size_16/standard/numbered/ML00009917_numbered.png,2026-03-19 06:58:10.544876
7535,ML00010681,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(O)CCc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7536,ML00000693,CHEMBL182892,,CC(C)C[C@H](NC(=O)[C@@H]1CC(=O)NC/C=C/CCCOC(=O)N[C@@H](C(C)C)C(=O)N1)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7537,ML00004892,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc(CN3CCCCCC3)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004892_numbered.png,2026-03-19 06:58:10.615797
7538,ML00004859,,,CCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@@H](C/C=C/c4cncc5ccccc45)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(=O)CC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7539,ML00010558,,,CCC(=O)O[C@H]1CC(=O)O[C@@H](C)C/C=C\C=C/[C@@H](O)[C@@H](C)C[C@H](CC)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010558_numbered.png,2026-03-19 06:58:10.671520
7540,ML00010280,,,CC1=N[C@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O[C@H](/C(C)=C/c3csc(C)n3)C[C@@H]2O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00010280_numbered.png,2026-03-19 06:58:10.718177
7541,ML00009050,,,CO/C1=C\C(C)=C\C(C)C(=O)[C@@H](C)C/C(C)=C/C=C/C(OC)[C@@H]([C@@H](C)C(=O)[C@H](C)C2=CC(=O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009050_numbered.png,2026-03-19 06:58:10.765383
7542,ML00000897,CHEMBL4080332,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)C[C@H](O)[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c2c(c1=O)N[C@H]([C@@H]1NC(=O)[C@H](C)N(C)C(=O)CN(C)C(=O)[C@@H]3CC(=O)CN3C(=O)[C@@H](C(C)C)NC1=O)COC2=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7543,ML00003777,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003777_numbered.png,2026-03-19 06:58:10.828662
7544,ML00001419,CHEMBL318975,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3cc(C)ccc3C)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7545,ML00009173,,,CO[C@H]1[C@H](OC[C@H]2[C@@H]3O[C@@H]3/C=C/C(=O)[C@H](C)CC[C@H](O[C@@H]3O[C@H](C)C[C@H](O)[C@H]3O)[C@@H](C)/C=C/C(=O)O[C@@H]2C)O[C@H](C)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,6.0,"[3, 4, 9, 10, 13, 14]",ring_size_16/standard/numbered/ML00009173_numbered.png,2026-03-19 06:58:10.876644
7546,ML00010557,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCO)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010557_numbered.png,2026-03-19 06:58:10.927092
7547,ML00005096,,,C/C=C(\NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCN1C(=O)/C(=C/C)NC(=O)CCCC(=O)O)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCO)C(=O)N[C@H](CCN)C(=O)N[C@@H](CCCCN)C(=O)O[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7548,ML00004239,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@@H]([C@H](C)[C@H](O)[C@H](C)[C@]2(OC)C[C@H](OC(=O)/C=C/C(=O)O)[C@@H](C)[C@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00004239_numbered.png,2026-03-19 06:58:10.992144
7549,ML00001926,CHEMBL250295,,C[C@@]1(N)Cc2cccc(c2)CC[C@H](c2ccccc2)NC(=O)c2cc(cc(N(c3ccccc3)S(C)(=O)=O)c2)COC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7550,ML00002918,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)/C=C\C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002918_numbered.png,2026-03-19 06:58:11.046288
7551,ML00004819,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@@H]4OC(=O)N(CCCc5ccccc5)[C@@H]4/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004819_numbered.png,2026-03-19 06:58:11.092993
7552,ML00010469,,,CC(=O)[C@@]12CC/C=C\C(=O)O[C@@H]3C[C@H]4O[C@@H]5C=C(C)CC[C@]5(COC(=O)[C@H]5O[C@]5(CCO1)[C@@H]2O)[C@]3(C)[C@]41CO1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7553,ML00008816,,,COc1ccc(C[C@@H]2NC(=O)/C=C\C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7554,ML00010902,,,C/C=C/CC(O)[C@@H](C)[C@H](O)[C@H](C)[C@H]1OC(=O)/C(OC)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00010902_numbered.png,2026-03-19 06:58:11.150922
7555,ML00007361,,,CC[C@@H]1/C=C\[C@H]([C@H](C)O)OC(=O)/C(C)=C\[C@@H]2C(=O)NC3=CC(=O)c4c(cc(C)c(O)c4C(=O)CC1)[C@@]32O,standard_macrolactone,16.0,,,success,,5.0,"[3, 6, 9, 13, 16]",ring_size_16/standard/numbered/ML00007361_numbered.png,2026-03-19 06:58:11.187430
7556,ML00005214,,,CC[C@@H]1[C@@H](C)O[C@@](OC)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(C)=C/C=C/[C@H](C)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]3(OC)C[C@@H](O[C@H]4C[C@H](O)[C@H](O)[C@H](C)O4)[C@H](CC)[C@@H](C)O3)OC(=O)/C(C)=C/C=C/[C@@H]2C)C[C@H]1O[C@H]1C[C@H](O)[C@H](O)[C@H](C)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7557,ML00002327,,,CO[C@@H]1[C@@H](OC2OC(C)C(OC3CC(C)(O)C(OC(=O)CC(C)C)C(C)O3)C(N(C)C)C2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002327_numbered.png,2026-03-19 06:58:11.239352
7558,ML00002010,CHEMBL85841,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccc(I)cc2)NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7559,ML00001686,CHEMBL3650144,,CC(C)[C@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC(=O)C[C@@H](/C=C/CCS)OC(=O)CNC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7560,ML00006596,,,CC1CCC(NS(=O)(=O)Cc2ccccc2)CCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/ML00006596_numbered.png,2026-03-19 06:58:11.276885
7561,ML00009645,,,CCC[C@H]1C[C@@H]2CC[C@@H](O2)[C@H](C)C(=O)O[C@@H]([C@H](C)[C@H]2CC[C@@H](C[C@@H](CCC)N(C)C)O2)[C@H](C)[C@@H]2CC[C@@H](O2)[C@@H](CC)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7562,ML00010943,,,CCC1OC(=O)CC(O)C(C)C(OC2OC(C)C(O)C(N(C)C)C2O)C(CC=O)CC(C)C(=O)/C=C\C2(C)OC2C1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010943_numbered.png,2026-03-19 06:58:11.332445
7563,ML00004464,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCN2C(=O)c3ccccc3C2=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004464_numbered.png,2026-03-19 06:58:11.392197
7564,ML00009258,,,CC(/C=C/C=C(\C)[C@H](O)[C@@H](C)[C@@H]1C[C@H](O)[C@@]2(C)O[C@@H]2/C=C\[C@@H](C)[C@H]2C[C@H](CC(=O)O2)C[C@@H]2O[C@H]2C(=O)O1)=C\c1coc(C)n1,standard_macrolactone,16.0,,,success,,4.0,"[3, 5, 6, 10]",ring_size_16/standard/numbered/ML00009258_numbered.png,2026-03-19 06:58:11.427464
7565,ML00004895,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004895_numbered.png,2026-03-19 06:58:11.485008
7566,ML00010285,,,CO[C@@H]1C/C=C/[C@H](C)[C@@H]2O[C@](O)([C@H](C)C(=O)O[C@H](c3ccccc3)CCCC1)[C@H](OC)[C@@H](O)[C@@H]2C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7567,ML00010372,,,CC1=C[C@@H]2O[C@H]3C[C@@H]4OC(=O)/C=C\C=C/[C@]5([C@H](C)O)OCC/C(=C/C(=O)OC[C@]2(CC1)[C@@]4(C)[C@@]31CO1)[C@H]5O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7568,ML00010648,,,CC(C)C[C@@H]1OC(=O)CCNC(=O)[C@@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7569,ML00009270,,,CO[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2CC[C@@](C)(O)C(=O)/C=C\[C@H]3O[C@H]3[C@H](CO[C@H]3O[C@@H](C)[C@H](O)[C@H](OC)[C@H]3OC)[C@@H](C)OC(=O)/C=C\[C@H]2C)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 10, 13, 14]",ring_size_16/standard/numbered/ML00009270_numbered.png,2026-03-19 06:58:11.551469
7570,ML00001665,CHEMBL3251863,,CCCC(=O)O[C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](OC(C)=O)[C@H](OC)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@H]1C,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001665_numbered.png,2026-03-19 06:58:11.599812
7571,ML00005541,,,CC[C@H]1OC(=O)C[C@@H](O)[C@@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@@H](O[C@H]3CC[C@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H](CC=O)C[C@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO[C@H]1O[C@@H](C)[C@H](O)[C@@H](OC)[C@@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005541_numbered.png,2026-03-19 06:58:11.658662
7572,ML00001598,CHEMBL1483648,,COC1C(O)CC(=O)OC(C)C/C=C/C=C/[C@@H](OC2CCC(N(C)C)C(C)O2)C(C)C[C@@H](CC=O)[C@@H]1O[C@H]1OC(C)[C@H](O[C@@H]2C[C@@](C)(O)C(O)C(C)O2)C(N(C)C)C1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001598_numbered.png,2026-03-19 06:58:11.714731
7573,ML00008984,,,COC1=CC(C)=CC(C)C(O)C(C)CC(C)=CC=CC(OC)C(C(C)C(O)C(C)C2(O)CC(O)C(C)C(C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00008984_numbered.png,2026-03-19 06:58:11.772661
7574,ML00007660,,,C/C1=C/CC/C=C\C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007660_numbered.png,2026-03-19 06:58:11.821197
7575,ML00009637,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@H](O[C@H]2O[C@@H](C)[C@H](O[C@@H]3CC[C@@H](O)[C@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@H](/C=C\O)C[C@H](C)C(=O)/C=C\[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009637_numbered.png,2026-03-19 06:58:11.877247
7576,ML00000924,CHEMBL3326015,,CC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C=C(\C)CC/C=C(\C)CCCOC(=O)CCCSSCCCC(=O)O[C@H]1[C@@H](C)CCC[C@H]2O[C@H]2C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00000924_numbered.png,2026-03-19 06:58:11.929405
7577,ML00000066,CHEMBL3593409,,CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2cccc(n2)CNC(=O)C[C@@H](/C=C/CCS)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7578,ML00000992,CHEMBL582086,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)C(O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00000992_numbered.png,2026-03-19 06:58:11.986631
7579,ML00003432,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003432_numbered.png,2026-03-19 06:58:12.051749
7580,ML00001338,CHEMBL294895,,O=C(NC(Cc1ccccc1)C(O)CN1CCCC/C=C/CCCCCCC(c2ccccc2)OC1=O)O[C@H]1CO[C@H]2OCC[C@@H]12,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7581,ML00008976,,,CO/C1=C/C(C)=C\[C@@H](C)[C@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@]2(O)C[C@H](O)[C@@H](C)[C@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00008976_numbered.png,2026-03-19 06:58:12.108226
7582,ML00008139,,,CC1CCC(O)C=CC(=O)OC(C)CCC(O)C=CC(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7583,ML00003535,,,C[C@@H]1NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)/C=C/C=C/CCCO)COC(=O)[C@@H]2C[C@@H](C)CN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7584,ML00001333,CHEMBL84700,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccc(N(C)C)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7585,ML00004660,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@@H]4OC(=O)N(Cc5ccccc5)[C@@H]4/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004660_numbered.png,2026-03-19 06:58:12.177141
7586,ML00008233,,,C[C@@H]1OC(=O)/C=C\[C@@H](O)[C@H](C)OC(=O)C[C@@H](C)OC(=O)/C=C\[C@H]1O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7587,ML00000721,CHEMBL378483,,CN1C2CCC1C1COC(=O)CCC3(CCC(=O)Nc4ccc(cc4)C1C2)c1ccccc1-c1ccccc13,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7588,ML00010141,,,O=C1C[C@@H](c2ccc(O)cc2)c2c(O)cc(O)c3c(=O)c(O)c(oc23)-c2cc(O)c(O)c(c2)O[C@@H]2O[C@@H](CO1)[C@@H](O)[C@H](O)[C@@H]2O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7589,ML00002744,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3C[C@@](C)(O)[C@H](OC(=O)CC(C)C)[C@H](C)O3)[C@@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002744_numbered.png,2026-03-19 06:58:12.245725
7590,ML00005506,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN2C[C@@H](C)C[C@@H](C)C2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005506_numbered.png,2026-03-19 06:58:12.305320
7591,ML00010942,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010942_numbered.png,2026-03-19 06:58:12.366472
7592,ML00006923,,,O=C1CCCCCCCCCCC(NS(=O)(=O)c2ccc(Cl)cc2)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006923_numbered.png,2026-03-19 06:58:12.393787
7593,ML00006679,,,CCCCCCCON=C1CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006679_numbered.png,2026-03-19 06:58:12.417636
7594,ML00002829,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)/C(C)=C/C)C(C)C)[C@@H](C)OC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CCC(=O)O)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7595,ML00000726,CHEMBL4083729,,Cc1cc2cc(C)c1CCOC(=O)Nc1ccc(S(=O)(=O)C3CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2cc[nH]c(=O)c2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7596,ML00009614,,,CC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](C)C[C@@H](C)C(=O)/C=C\[C@H]2O[C@@H]2[C@]1(O)CO[C@@H]1O[C@H](C)[C@@H](O)[C@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009614_numbered.png,2026-03-19 06:58:12.486119
7597,ML00002715,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=O)/C=C/C=C/[C@@H]1CSc1ccccc1,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002715_numbered.png,2026-03-19 06:58:12.536371
7598,ML00001187,CHEMBL3906646,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1cc(F)c(OC(CF)CF)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7599,ML00003776,,,CC[C@H]1OC(=O)C[C@@H](O)[C@@H](C)[C@@H](O[C@H]2O[C@H](C)[C@H](O)[C@@H](N(C)C)[C@@H]2O)[C@H](CC=O)C[C@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO[C@H]1O[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003776_numbered.png,2026-03-19 06:58:12.596727
7600,ML00004360,,,CC[C@@H]1[C@@H](C)O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C=C/C=C/[C@H](C)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]3(OC)C[C@@H](O[C@H]4C[C@H](O)[C@H](O)[C@H](C)O4)[C@H](CC)[C@@H](C)O3)OC(=O)/C=C/C=C/[C@@H]2C)C[C@H]1O[C@H]1C[C@H](O)[C@H](O)[C@H](O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7601,ML00009577,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=O)/C=C/C=C/[C@@H]1CI,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009577_numbered.png,2026-03-19 06:58:12.652779
7602,ML00007510,,,C/C(=C\c1csc(C)n1)[C@@H]1C/C=C/CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,7.0,"[3, 10, 11, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00007510_numbered.png,2026-03-19 06:58:12.694859
7603,ML00002121,CHEMBL251307,,C[C@@]1(N)Cc2cccc(c2)CC[C@H](c2ccccc2)NC(=O)c2cc(cc(-c3ncco3)c2)COC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7604,ML00001660,CHEMBL3251870,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2OC(C)=O)[C@@H](CC=O)C[C@@H](C)[C@@H](OC(C)=O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001660_numbered.png,2026-03-19 06:58:12.748834
7605,ML00006206,,,CCCO[C@@H]1[C@@H](N(C)C)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@H](CC)[C@@H](CO[C@@H]2O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]2OC)/C=C(C)/C=C/C(=O)[C@H](C)C[C@@H]1CCN1C(=O)c2ccccc2C1=O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006206_numbered.png,2026-03-19 06:58:12.807249
7606,ML00001482,CHEMBL409074,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccc(NC(=O)OCC3c4ccccc4-c4ccccc43)cc2)NC(=O)/C=C/C[C@@H]([C@H](C)C2OC2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7607,ML00009072,,,COC1=CC(C)=CC(C)C(O)C(C)CC(C)=CC=CC(OC)C(C(C)C(O)C(C)C(=O)/C=C/C(C)C(O)C(C)C)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009072_numbered.png,2026-03-19 06:58:12.861059
7608,ML00008455,,,CC[C@@H]1OC(=O)CCC/C=C\C/C=C\C/C=C\[C@@H]2[C@H]1C[C@@H](O)[C@@H]2O,standard_macrolactone,16.0,,,success,,1.0,[3],ring_size_16/standard/numbered/ML00008455_numbered.png,2026-03-19 06:58:12.883739
7609,ML00008819,,,CC[C@H](C)[C@@H]1OC(=O)[C@H](C)CNC(=O)[C@@H](Cc2ccc(OC)c(Cl)c2)NC(=O)/C=C\C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7610,ML00010312,,,CCC1C[C@@H](C)[C@@H](O)/C=C\C=C/C[C@H](C)OC(=O)C[C@H](O)[C@@H](OC)[C@H]1O[C@@H]1O[C@H](C)C[C@@](O)(C(C)=O)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010312_numbered.png,2026-03-19 06:58:12.933075
7611,ML00003763,,,CC[C@@H]1O[C@](O)([C@H](C)[C@H](O)[C@H](C)[C@@H]2OC(=O)/C(C)=C\C(C)=C/[C@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H]2OC)C[C@H](OC(=O)/C=C/C(N)=O)[C@@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00003763_numbered.png,2026-03-19 06:58:12.978937
7612,ML00004905,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc([N+](=O)[O-])cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004905_numbered.png,2026-03-19 06:58:13.035203
7613,ML00001113,CHEMBL1915491,PORPOISAMIDE B,CCCCC[C@H]1NC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)OC(=O)[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7614,ML00002299,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@@H](C)O3)[C@@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002299_numbered.png,2026-03-19 06:58:13.088035
7615,ML00002920,,,CO[C@@H]1[C@H](O)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O[C@H]2CC[C@H](N(C)C)[C@H](C)O2)[C@H](C)C[C@H](CC=O)[C@H]1O[C@H]1O[C@@H](C)[C@@H](O[C@@H]2C[C@](C)(O)[C@H](O)[C@H](C)O2)[C@@H](N(C)C)[C@@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002920_numbered.png,2026-03-19 06:58:13.134842
7616,ML00002625,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@H](CC=O)C[C@@H](C)C(=O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@@H](OC(=O)CC)[C@H]3OC)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002625_numbered.png,2026-03-19 06:58:13.180801
7617,ML00003253,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN2C(=O)c3ccccc3C2=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003253_numbered.png,2026-03-19 06:58:13.232834
7618,ML00006652,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O)[C@@H]([C@H](C)O)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006652_numbered.png,2026-03-19 06:58:13.282804
7619,ML00007237,,,CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCSCc2ccccn2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7620,ML00009851,,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(OC)C[C@@H](O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009851_numbered.png,2026-03-19 06:58:13.337423
7621,ML00004662,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc(Oc3ccccc3)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004662_numbered.png,2026-03-19 06:58:13.392036
7622,ML00000028,CHEMBL3902498,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(S(=O)(=O)C3CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)ncc(F)c2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7623,ML00006533,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc(OC(C)=O)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006533_numbered.png,2026-03-19 06:58:13.453073
7624,ML00008820,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Br)c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7625,ML00002339,,,CCCC(=O)O[C@@H]1[C@@H](C)O[C@@H](O[C@H]2[C@H](C)O[C@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C/C=C\C=C/C(=O)[C@H](C)C[C@@H]3CC=O)[C@@H](O)[C@@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002339_numbered.png,2026-03-19 06:58:13.506497
7626,ML00001641,CHEMBL42743,TYLOSIN,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001641_numbered.png,2026-03-19 06:58:13.561585
7627,ML00000031,CHEMBL3593247,,CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCS)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7628,ML00001181,CHEMBL4110036,,CC(C)S(=O)(=O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1cc(F)c3c(N)nccc3c1)c1ccc(cc1)CCOC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7629,ML00002742,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@@H](CC=O)C(O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002742_numbered.png,2026-03-19 06:58:13.622083
7630,ML00001191,CHEMBL3917941,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1cc(F)c(S(=O)(=O)C3CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1cc(F)c2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7631,ML00000168,CHEMBL196234,,CSc1nc(/C=C(\C)[C@@H]2C[C@@H]3C[C@H]3CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)CCC(=O)O2)cs1,standard_macrolactone,16.0,,,success,,7.0,"[3, 10, 11, 12, 13, 14, 14]",ring_size_16/standard/numbered/ML00000168_numbered.png,2026-03-19 06:58:13.669320
7632,ML00002732,,,CCO[C@@H]1[C@@H](C)O[C@@H](O[C@H]2[C@H](C)O[C@H](O[C@H]3[C@@H](OC)[C@@H](O)CC(=O)O[C@@H](C)C/C=C\C=C/[C@@H](OC(C)=O)[C@@H](C)C[C@@H]3CC=O)[C@@H](OC(C)=O)[C@@H]2N(C)C)C[C@@]1(C)OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002732_numbered.png,2026-03-19 06:58:13.718641
7633,ML00001283,CHEMBL3251869,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](OC(C)=O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001283_numbered.png,2026-03-19 06:58:13.768488
7634,ML00004913,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCCCCCCc4ccccc4)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004913_numbered.png,2026-03-19 06:58:13.823358
7635,ML00006424,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(OC3CC(C)(O)C(O)C(C)O3)C(N(C)C)C2O)[C@@H](CC=O)C[C@@H](C)C(=O)CCC(C)C[C@@H]1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006424_numbered.png,2026-03-19 06:58:13.877424
7636,ML00000719,CHEMBL123698,,COc1ccc(C[C@H]2NC(=O)/C=C/CC([C@H](C)C3OC3c3ccccc3)OC(=O)[C@@H](CC(C)C)OC(=O)CCNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7637,ML00006796,,,CC(Oc1ccc(Cl)cc1)C(=O)ON=C1CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006796_numbered.png,2026-03-19 06:58:13.906893
7638,ML00009639,,,CC[C@@H]1OC(=O)/C=C\[C@H](C)[C@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](C)C[C@@H](C)C(=O)/C=C\C=C/[C@@H]1CO[C@H]1O[C@@H](C)[C@H](O)[C@@H](OC)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009639_numbered.png,2026-03-19 06:58:13.952108
7639,ML00009081,,,CO[C@H]1O[C@@H](OC[C@H]2[C@@H]3O[C@@H]3/C=C\C(=O)[C@](C)(O)CC[C@@H](O[C@H]3O[C@@H](C)[C@](O)([C@H](C)O)C[C@@H]3O)[C@H](C)/C=C\C(=O)O[C@@H]2C)[C@H](C)[C@@H](O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 10, 13, 14]",ring_size_16/standard/numbered/ML00009081_numbered.png,2026-03-19 06:58:13.996960
7640,ML00005402,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)C[C@H](O)[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)OC[C@H](O)[C@@H]2NC(=O)[C@H](C)N(C)C(=O)CN(C)C(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](C(C)C)NC2=O)c(N)c1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7641,ML00004571,,,CC[C@@H]1[C@@H](C)O[C@@](OC)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C=C/C=C/[C@H](C)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]3(OC)C[C@@H](O[C@H]4C[C@H](O)[C@H](O)[C@H](O)O4)[C@H](CC)[C@@H](C)O3)OC(=O)/C=C/C=C/[C@@H]2C)C[C@H]1O[C@H]1C[C@H](O)[C@H](O)[C@H](C)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7642,ML00002308,,,CO[C@H]1[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C\C=C/C(=O)[C@H](C)C[C@H](CCO)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O2)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002308_numbered.png,2026-03-19 06:58:14.058886
7643,ML00004654,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=N/OCCCCc2ccc3ncccc3c2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004654_numbered.png,2026-03-19 06:58:14.113443
7644,ML00006055,,,CCCC(=O)O[C@H]1CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O[C@H]2C[C@@H](N(C)C)C[C@H](C)O2)[C@H](C)C[C@H](CC=O)[C@@H](O[C@H]2C[C@H](C)[C@H](O[C@@H]3C[C@](C)(O)[C@@H](O)[C@@H](C)O3)[C@H](N(C)C)[C@@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006055_numbered.png,2026-03-19 06:58:14.162241
7645,ML00008190,,,C[C@@H]1CCC(=O)/C=C\C(=O)O[C@H](C)CCC(=O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7646,ML00006552,,,CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCCCCCCCN=C(N)N)[C@@H](C)OC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCN)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7647,ML00010068,,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H]([C@H](C)O)NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7648,ML00002993,,,C=C1Oc2cc(OC)cc(C(=O)O[C@H]3COC(=O)C[C@H](N)c4ccc(c(O)c4)O[C@@H]4C#C/C=C/3C#CC3=CC=C[C@@]34O[C@@H]3OC(C)(C)[C@@H](N(C)C)[C@@H](O)[C@H]3O)c2NC1=O,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7649,ML00009790,,,CC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](C)C[C@@H](C)C(=O)/C=C\C=C/[C@@H]1CO[C@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009790_numbered.png,2026-03-19 06:58:14.233113
7650,ML00010937,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010937_numbered.png,2026-03-19 06:58:14.283583
7651,ML00003518,,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](C(=O)OCCC(=O)O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00003518_numbered.png,2026-03-19 06:58:14.329820
7652,ML00002295,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H](CC=O)C[C@@H](C)C(=O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002295_numbered.png,2026-03-19 06:58:14.375144
7653,ML00010281,,,COC1=N[C@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O[C@H](/C(C)=C/c3csc(C)n3)C[C@@H]2O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00010281_numbered.png,2026-03-19 06:58:14.419935
7654,ML00002011,CHEMBL262960,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccc(N)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7655,ML00008823,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](I)c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7656,ML00006850,,,C/C=C1\NC(=O)[C@@H]2CSSCC/C=C/[C@@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7657,ML00001594,CHEMBL3251874,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](N(C)C)[C@@H](OC(C)=O)[C@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)O[C@@H]2C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001594_numbered.png,2026-03-19 06:58:14.486295
7658,ML00002302,,,CCCC(=O)O[C@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](C)O[C@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](C)C/C=C\C=C/C(=O)[C@@H](C)C[C@@H]3CC=O)[C@@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002302_numbered.png,2026-03-19 06:58:14.532424
7659,ML00006445,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN2C(=O)c3ccccc3C2=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006445_numbered.png,2026-03-19 06:58:14.586187
7660,ML00001612,CHEMBL3244595,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](N(C)C)[C@@H](OC(C)=O)[C@H](O[C@@H]3[C@@H](OC)[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)O[C@@H]2C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001612_numbered.png,2026-03-19 06:58:14.635557
7661,ML00001402,CHEMBL3251853,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001402_numbered.png,2026-03-19 06:58:14.681297
7662,ML00005930,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)CC[C@@H](C/C=C2\Nc3ccccc3S2)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 6, 9, 10, 13, 14, 15]",ring_size_16/standard/numbered/ML00005930_numbered.png,2026-03-19 06:58:14.730851
7663,ML00008814,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7664,ML00008887,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(C)CC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00008887_numbered.png,2026-03-19 06:58:14.787875
7665,ML00002265,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccc(COC(=O)C(C)(C)CN)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7666,ML00002753,,,CO[C@H]1[C@H](OC)CO[C@@H](O[C@H]2C[C@H]3C[C@@H]([C@H]4C[C@@H]4C)OC(=O)C[C@@H]4O[C@@H](C[C@H](O[C@@H]5OC[C@@H](OC)[C@H](OC)[C@H]5O)[C@H]4C)C[C@@H]([C@H]4C[C@@H]4C)OC(=O)C[C@H](O3)[C@@H]2C)[C@@H]1OC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7667,ML00003067,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@]2(O)C[C@@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3OC)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00003067_numbered.png,2026-03-19 06:58:14.847669
7668,ML00010923,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/C(=O)[C@@H](C)C[C@@H](CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010923_numbered.png,2026-03-19 06:58:14.893771
7669,ML00001992,CHEMBL3349529,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7670,ML00009633,,,CC[C@@H]1OC(=O)/C=C\[C@H](C)[C@H](O[C@@H]2O[C@@H](C)C[C@@H](N(C)C)[C@H]2O)[C@H](C)C[C@@H](C)C(=O)/C=C\C=C/[C@@]1(O)CO[C@@H]1O[C@@H](C)[C@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009633_numbered.png,2026-03-19 06:58:14.955351
7671,ML00007876,,,CC(=O)C[C@@H]1CC(=O)O[C@@H](C)C/C=C\C(=O)O[C@@H](C)[C@H](O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7672,ML00005773,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005773_numbered.png,2026-03-19 06:58:15.027709
7673,ML00006619,,,CC[C@H]1C[C@@H](C)C(=O)/C=C\C(C)=C/[C@H](C)[C@@H]([C@H](C)O)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006619_numbered.png,2026-03-19 06:58:15.081500
7674,ML00009260,,,C/C1=C/C=C\[C@@H](C)[C@H]2C[C@@H](C/C=C\C(=O)O[C@H]([C@H](C)[C@@H](O)/C(C)=C/C=C/C(C)=C/c3coc(C)n3)C[C@@H]1O)CC(=O)O2,standard_macrolactone,16.0,,,success,,4.0,"[3, 5, 6, 10]",ring_size_16/standard/numbered/ML00009260_numbered.png,2026-03-19 06:58:15.120183
7675,ML00005549,,,CCC(=O)O[C@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](C)C/C=C\C=C/[C@H](OC(C)=O)[C@@H](C)C[C@@H]3CC=O)[C@@H](O)[C@H]2N(C)C)[C@H](O)[C@@]1(C)OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005549_numbered.png,2026-03-19 06:58:15.174426
7676,ML00001190,CHEMBL4106751,,Cc1cc2cc(C)c1C(F)(F)COC(=O)Nc1ccc(S(=O)(=O)C3CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7677,ML00009820,,,CO[C@H]1[C@H](OC[C@H]2[C@@H]3O[C@H]3CCC(=O)[C@H](C)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@](O)([C@H](C)O)[C@H]3O)[C@@H](C)/C=C/C(=O)O[C@@H]2C)O[C@H](C)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009820_numbered.png,2026-03-19 06:58:15.235514
7678,ML00006837,,,C[C@@H]1CCCCCCCCC[C@H](OC(=O)CCC(=O)OC(C)(C)C)C(=O)/C=C/C(=O)O1,standard_macrolactone,16.0,,,success,,3.0,"[3, 13, 14]",ring_size_16/standard/numbered/ML00006837_numbered.png,2026-03-19 06:58:15.268875
7679,ML00007503,,,Cc1nc(/C=C(\CO)[C@@H]2C/C=C\CCC[C@H](C)[C@H](O)CC(=O)C(C)(C)[C@@H](O)CC(=O)O2)cs1,standard_macrolactone,16.0,,,success,,7.0,"[3, 10, 11, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007503_numbered.png,2026-03-19 06:58:15.317154
7680,ML00006191,,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccc(NC(=O)OCC3c4ccccc4-c4ccccc43)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7681,ML00000276,CHEMBL3942944,,COC(=O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1ccc3c(N)nccc3c1)c1ccc(c(C)c1)[C@@H](C)COC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7682,ML00002042,CHEMBL4073823,,CCc1cc2cc(CC)c1CCOC(=O)Nc1cccc(c1)CNC(=O)C2Nc1cccc(C(N)=O)c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7683,ML00002935,,,NC(=O)CNC(=O)C1CCCN1C(=O)C1CCCCNOC(=O)CCC(NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)NC(Cc2c[nH]c3ccccc23)C(=O)N1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7684,ML00000102,CHEMBL3593410,,CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2cc(ccn2)C2=N[C@@](C)(CS2)C(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7685,ML00001153,CHEMBL3930738,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1cc(F)c(O[C@H]3CCOC3)c(c1)CN(C)C(=O)C2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7686,ML00009005,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(CC)CC)C[C@@H](C)C(=O)/C=C/[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009005_numbered.png,2026-03-19 06:58:15.424310
7687,ML00000752,CHEMBL3235697,,CCC(=O)N[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7688,ML00002722,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002722_numbered.png,2026-03-19 06:58:15.488180
7689,ML00004450,,,CC[C@@H]1[C@@H](C)O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C=C/C=C/[C@H](C)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]3(O)C[C@@H](O[C@H]4C[C@H](O)[C@H](O)[C@H](O)O4)[C@H](CC)[C@@H](C)O3)OC(=O)/C=C/C=C/[C@@H]2C)C[C@H]1O[C@H]1C[C@H](O)[C@H](O)[C@H](C)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7690,ML00006379,,,CCC1OC(=O)CC(O)C(C)C(OC2OC(C)C(OC3CC(C)(O)C(O)C(C)O3)C(N(C)C)C2O)C(CC=O)CC(C)C(=O)/C=C/C(C)=C/C1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006379_numbered.png,2026-03-19 06:58:15.560654
7691,ML00005884,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC(=O)/C=C\C(=O)NC3=C(O)CCC3=O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00005884_numbered.png,2026-03-19 06:58:15.615069
7692,ML00000368,CHEMBL235082,,CC(C)[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)N[C@H](C(C)C)C(=O)NCC(=O)O2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7693,ML00009920,,,COC(=O)C[C@@H]1C/C=C\C(=O)O[C@@H]([C@H](C)[C@@H](OC)/C(C)=C/C=C/C(C)=C\c2coc(C)n2)C[C@H](O)[C@]2(C)O[C@@H]2/C=C\[C@@H](C)[C@H](O)C1,standard_macrolactone,16.0,,,success,,6.0,"[3, 5, 6, 10, 11, 13]",ring_size_16/standard/numbered/ML00009920_numbered.png,2026-03-19 06:58:15.668704
7694,ML00001388,CHEMBL328454,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H]2O[C@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7695,ML00005577,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](O)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO[C@H]1C[C@@H](OC)[C@H](O)[C@@H](C)O1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005577_numbered.png,2026-03-19 06:58:15.738168
7696,ML00009573,,,CCC[C@H]1C[C@@H]2CC[C@@H](O2)[C@H](C)C(=O)O[C@@H]([C@H](CC)[C@H]2CC[C@@H](C[C@@H](CCC)N(C)C)O2)[C@H](C)[C@@H]2CC[C@@H](O2)[C@@H](CC)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7697,ML00006704,,,O=C1CCCCCCCCCCC(=NOC(=O)COc2ccccc2)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006704_numbered.png,2026-03-19 06:58:15.768832
7698,ML00005883,,,COC1=CC(C)=CC(C)C(O)C(C)CC(C)=CC=CC(OC)C(C(C)C(O)C(C)C2(O)CC(OC(=O)/C=C/C(=O)NC3=C(O)CCC3=O)C(C)C(C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00005883_numbered.png,2026-03-19 06:58:15.815952
7699,ML00010286,,,COC(=O)[C@@H](C)[C@H](O)[C@H](C)[C@H]1OC(=O)/C(OC)=C/C(C)=C/[C@@H](C)C(=O)[C@@H](C)C/C(C)=C/C=C/[C@@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00010286_numbered.png,2026-03-19 06:58:15.865988
7700,ML00003390,,,CCC(=O)O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003390_numbered.png,2026-03-19 06:58:15.919629
7701,ML00007687,,,COC1C(OCC2C(C)OC(=O)/C=C\C(C)C(O)CCC(C)(O)C(=O)/C=C\C3OC32)OC(C)C(O)C1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 10, 13, 14]",ring_size_16/standard/numbered/ML00007687_numbered.png,2026-03-19 06:58:15.968615
7702,ML00010375,,,CC(=O)[C@@]12CC/C=C\C(=O)O[C@@H]3C[C@@H]4O[C@H]5C=C(C)CC[C@@]5(COC(=O)C=C(CCO1)[C@@H]2O)[C@@]3(C)[C@@]41CO1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7703,ML00005790,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005790_numbered.png,2026-03-19 06:58:16.034448
7704,ML00007686,,,CCC[C@]1(C)C[C@@H]2OC(=O)/C=C\[C@@H](C)CC(=O)O[C@@H](CC(C)=O)[C@H](C)/C=C(/C)CC[C@@H]2O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7705,ML00006440,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCO)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006440_numbered.png,2026-03-19 06:58:16.097540
7706,ML00002632,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=O)/C=C/C=C/[C@@H]1CSc1ncccn1,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002632_numbered.png,2026-03-19 06:58:16.151588
7707,ML00001389,CHEMBL86696,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7708,ML00002657,,,CCC(=O)O[C@H]1[C@@H](C)O[C@@H](O[C@H]2[C@H](C)O[C@H](O[C@H]3[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C\[C@H]4O[C@H]4C[C@@H](C)OC(=O)C[C@@H](OC(=O)CC)[C@H]3OC)[C@H](O)[C@H]2N(C)C)C[C@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002657_numbered.png,2026-03-19 06:58:16.213578
7709,ML00007362,,,CCCCC[C@@H]1C/C=C(/C)[C@@H](O)C(C)(C)C(=O)[C@@H](C)/C=C(/C)[C@@H]2C[C@H](O)C[C@](O)(CC(=O)O1)O2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7710,ML00001974,CHEMBL1317175,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C\[C@H](OC)C([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)C(C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00001974_numbered.png,2026-03-19 06:58:16.274306
7711,ML00009253,,,C/C1=C/C=C\[C@@H](C)[C@H](O)C[C@H](CC(=O)O)C/C=C\C(=O)O[C@H]([C@H](C)[C@@H](O)/C(C)=C/C=C/C(C)=C/c2coc(C)n2)C[C@@H]1O,standard_macrolactone,16.0,,,success,,6.0,"[3, 5, 6, 10, 11, 13]",ring_size_16/standard/numbered/ML00009253_numbered.png,2026-03-19 06:58:16.315640
7712,ML00010914,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010914_numbered.png,2026-03-19 06:58:16.368843
7713,ML00003313,,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7714,ML00000013,CHEMBL1173445,LARGAZOLE,CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)C2=N[C@@](C)(CS2)C(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7715,ML00000042,CHEMBL264224,ARENASTATIN A,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7716,ML00006938,,,CC[C@H]1C[C@H](C)[C@@H](O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@H](OC)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006938_numbered.png,2026-03-19 06:58:16.431504
7717,ML00001581,CHEMBL99640,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccc(CNC(=O)CN(C)C(=O)OC(C)(C)C)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7718,ML00007644,,,C/C1=C/C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)[C@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC1,standard_macrolactone,16.0,,,success,,8.0,"[3, 6, 10, 11, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00007644_numbered.png,2026-03-19 06:58:16.483869
7719,ML00005885,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@H](OC)[C@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC(=O)/C=C/C(=O)NC3=C(O)CCC3=O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00005885_numbered.png,2026-03-19 06:58:16.531881
7720,ML00003527,,,CCCC/C=C/C(=O)N[C@@H](Cc1cccc(F)c1)C(=O)N[C@@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H]2CCCCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7721,ML00001981,CHEMBL262368,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)C3(CC3)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7722,ML00010940,,,CCC1OC(=O)CC(O)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(CC=O)CC(C)C(=O)/C=C/C2(C)OC2C1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010940_numbered.png,2026-03-19 06:58:16.596872
7723,ML00001167,CHEMBL3808801,,CN1Cc2cccc(c2)NC(=O)OCC(C)(C)c2ccc(cc2)[C@@H](Nc2ccc3c(N)nccc3c2)C1=O,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7724,ML00000310,CHEMBL3235373,,C[C@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)Cc2ccccc2)[C@@H](C)OC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7725,ML00005770,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@@H]4OC(=O)N[C@@H]4/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005770_numbered.png,2026-03-19 06:58:16.661873
7726,ML00000118,CHEMBL1338329,,CO[C@@H]1COC(=O)C/C=C\[C@H](C)[C@@H](NS(=O)(=O)c2ccc(C)cc2)COC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7727,ML00008292,,,O=C1CCCCCCCCCCC(NS(=O)(=O)c2cccs2)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00008292_numbered.png,2026-03-19 06:58:16.693293
7728,ML00002686,,,CC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@H](N(C)C)[C@H]2O)[C@H](C)C[C@@H](C)C(=O)C[C@H](SC[C@@H](NC(C)=O)C(=O)O)[C@H]2O[C@@H]2[C@@H]1CO[C@H]1O[C@H](C)[C@H](O)[C@@H](OC)[C@@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 7, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00002686_numbered.png,2026-03-19 06:58:16.744496
7729,ML00010966,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010966_numbered.png,2026-03-19 06:58:16.795807
7730,ML00008223,,,C[C@@H]1OC(=O)C[C@@H](C)OC(=O)/C=C\[C@@H](O)[C@H](C)OC(=O)CCC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7731,ML00003400,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCF)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003400_numbered.png,2026-03-19 06:58:16.858519
7732,ML00001516,CHEMBL256912,POLYDISCAMIDE C,CCC(C)(C)[C@H](NC(=O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(Br)cc1)NC(=O)[C@@H](C)NC=O)C(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CS(=O)(=O)O)C(=O)N[C@@H]1C(=O)N(C)[C@@H](CCC(N)=O)C(=O)N[C@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](CC(=O)O)C(=O)O[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7733,ML00003771,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)[C@@H](O)/C=C\C=C/[C@H](O)[C@H](C)C[C@H](C(C)=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@H](O)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003771_numbered.png,2026-03-19 06:58:16.935159
7734,ML00003664,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CCCCCCC2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003664_numbered.png,2026-03-19 06:58:16.997468
7735,ML00009075,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)C(=O)/C=C/[C@H](C)[C@H](O)C(C)C)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009075_numbered.png,2026-03-19 06:58:17.051836
7736,ML00008237,,,CC1CC(=O)OC(C)C(O)C=CC(=O)OC(C)C(O)C=CC(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7737,ML00003384,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@@H]([C@H](C)[C@H](O)[C@H](C)[C@]2(O)C[C@H](OC(=O)/C=C/C(=O)O)[C@@H](C)[C@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00003384_numbered.png,2026-03-19 06:58:17.110791
7738,ML00000054,CHEMBL3891120,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(S(=O)(=O)C3CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7739,ML00001331,CHEMBL329990,,COc1ccc([C@H]2O[C@@H]2[C@@H](C)[C@@H]2C/C=C/C(=O)N[C@H](Cc3ccc(OC)c(Cl)c3)C(=O)NCC(C)(C)C(=O)O[C@@H](CC(C)C)C(=O)O2)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7740,ML00004417,,,CCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](C/C=C/c4ccnc5ccccc45)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(=O)CC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7741,ML00000104,CHEMBL3593408,,CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2cccc(n2)C2=N[C@@](C)(CS2)C(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7742,ML00001719,CHEMBL392361,,CN(c1cc2cc(n1)NCCCCc1cccc(c1)C[C@@](C)(N)C(=O)OC2)S(C)(=O)=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7743,ML00002919,,,CO[C@H]1[C@H](O)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O[C@H]2CC[C@H](N(C)C)[C@H](C)O2)[C@H](C)C[C@H](CC=O)[C@H]1O[C@H]1O[C@H](C)[C@H](O[C@H]2C[C@](C)(O)[C@H](O)[C@H](C)O2)[C@H](N(C)C)[C@@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002919_numbered.png,2026-03-19 06:58:17.199362
7744,ML00000198,CHEMBL3956096,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(C3(C(=O)O)CCCCC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)ncc(F)c2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7745,ML00010641,,,CC(C)C[C@@H]1OC(=O)CCNC(=O)[C@@H](Cc2ccc(O)c(Cl)c2)NC(=O)/C=C\C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7746,ML00000600,CHEMBL3317816,,CC(C)(C)OC(=O)NCC[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCS)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7747,ML00001928,CHEMBL1164839,FIJIOLIDE A,CC(=O)N[C@H]1CC(=O)OC[C@H](O)c2ccc3c(c2Cl)C2=CC=C[C@]2(O[C@@H]2OC(C)(C)[C@@H](N(C)C)[C@@H](O)[C@H]2O)[C@@H]3Oc2c(O)cc1cc2Cl,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7748,ML00000254,CHEMBL379333,,CN1C2CCC1C1COC(=O)CCC(=O)CCC(=O)Nc3ccc(cc3)C1C2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7749,ML00001265,CHEMBL540678,,CO[C@H]1CCCC[C@@H](c2ccccc2)OC(=O)[C@@H](C)[C@@]2(O)O[C@@H]([C@@H](C)/C=C/[C@H]1OC(=O)CCC1=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C1)[C@@H](C)[C@H](O)[C@H]2OC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7750,ML00001155,CHEMBL4114547,,CCS(=O)(=O)c1ccc2cc1CNC(=O)[C@H](Nc1ccc3c(N)nccc3c1)c1cc(C)c(c(C)c1)CCOC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7751,ML00000633,CHEMBL3317814,,C[C@@]12CSC(=N1)c1csc(n1)CNC(=O)C[C@@H](/C=C/CCS)OC(=O)[C@H](CCN)NC2=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7752,ML00007030,,,O=C1CCCCCCCCCCC2(CCCO1)N=N/C(=N/c1ccc(Cl)cc1)S2,standard_macrolactone,16.0,,,success,,0.0,[],ring_size_16/standard/numbered/ML00007030_numbered.png,2026-03-19 06:58:17.269923
7753,ML00006433,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](OC2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN2C[C@@H](C)C[C@@H](C)C2)CC(C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006433_numbered.png,2026-03-19 06:58:17.323456
7754,ML00004382,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=N/OCc2ccc(F)cc2)/C=C/C(C)=C/C1CO[C@@H]1C[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004382_numbered.png,2026-03-19 06:58:17.379166
7755,ML00006382,,,CCC1OC(=O)CC(O)C(C)C(OC2OC(C)C(OC3CC(C)(O)C(O)C(C)O3)C(N(C)C)C2O)C(CC=O)CC(C)C(=O)/C=C\C(C)=C/C1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006382_numbered.png,2026-03-19 06:58:17.433300
7756,ML00009407,,,CO[C@@H]1[C@@H](OC[C@@H]2[C@H](C)OC(=O)/C=C\[C@H](C)[C@H](O[C@H]3O[C@@H](C)C[C@@]4(OC(=O)O[C@H]4C)[C@@H]3O)[C@H](C)C[C@@H](CO)C(=O)/C=C\[C@H]3O[C@@H]32)O[C@@H](C)[C@@H](O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009407_numbered.png,2026-03-19 06:58:17.480211
7757,ML00002676,,,CCCC(=O)O[C@H]1[C@@H](C)O[C@H](O[C@@H]2[C@H](C)O[C@H](O[C@H]3[C@@H](OC)[C@@H](OC(C)=O)CC(=O)O[C@@H](C)C/C=C\C=C/[C@@H](O)[C@@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002676_numbered.png,2026-03-19 06:58:17.526063
7758,ML00001206,CHEMBL554564,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2OC(c3cccnc3)=N[C@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00001206_numbered.png,2026-03-19 06:58:17.573813
7759,ML00003423,,,CCCO[C@@H]1C[C@](OC)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@@H]2OC)O[C@H](C(C)C)[C@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00003423_numbered.png,2026-03-19 06:58:17.622361
7760,ML00008910,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CC(O)C2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00008910_numbered.png,2026-03-19 06:58:17.674508
7761,ML00002717,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=O)/C=C/C=C/[C@@H]1COS(=O)(=O)c1ccccc1,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002717_numbered.png,2026-03-19 06:58:17.724336
7762,ML00008911,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CCC2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00008911_numbered.png,2026-03-19 06:58:17.797442
7763,ML00003250,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](OC(=O)c3ccc([N+](=O)[O-])cc3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](OC(C)=O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003250_numbered.png,2026-03-19 06:58:17.845602
7764,ML00006849,,,C/C=C1\NC(=O)[C@@H]2CSSCC/C=C\[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7765,ML00007281,,,COC1C(OCC2C(C)OC(=O)/C=C\C(C)C(O)CCC(C)(O)C(=O)/C=C\C3OC32)OC(C)C(O)C1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 10, 13, 14]",ring_size_16/standard/numbered/ML00007281_numbered.png,2026-03-19 06:58:17.903802
7766,ML00000263,CHEMBL3900166,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(C3(C(=O)O)CCC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)ncc(F)c2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7767,ML00007054,,,CC1CCC(NS(=O)(=O)c2ccccc2Cl)CCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/ML00007054_numbered.png,2026-03-19 06:58:17.944487
7768,ML00000394,CHEMBL3978562,,CCOP(=O)(O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1ccc3c(N)nccc3c1)c1ccc(c(C)c1)[C@@H](C)COC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7769,ML00003528,,,CCCC/C=C/C(=O)N[C@@H](Cc1cccc(F)c1)C(=O)N[C@@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@@H]2CCCCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7770,ML00001401,CHEMBL3244597,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](OC(C)=O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001401_numbered.png,2026-03-19 06:58:18.014821
7771,ML00010965,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](N(C)C)[C@@H]2O)[C@H](CC=O)C[C@H](C)C(=O)/C=C\[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010965_numbered.png,2026-03-19 06:58:18.067435
7772,ML00001965,CHEMBL407385,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccc(N)cc2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7773,ML00009893,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@H](OC)[C@@H]([C@@H](C)/C=C(\C)C2=C[C@@H](OC)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009893_numbered.png,2026-03-19 06:58:18.122532
7774,ML00008951,,,COC(=O)C[C@@H]1C/C=C\C(=O)O[C@H]([C@H](C)[C@@H](O)/C(C)=C/C=C/C(C)=C/c2coc(C)n2)C[C@H](O)[C@@]2(C)O[C@@H]2/C=C\[C@@H](C)[C@H](O)C1,standard_macrolactone,16.0,,,success,,6.0,"[3, 5, 6, 10, 11, 13]",ring_size_16/standard/numbered/ML00008951_numbered.png,2026-03-19 06:58:18.163053
7775,ML00004663,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2cccc(Oc3ccccc3)c2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004663_numbered.png,2026-03-19 06:58:18.218058
7776,ML00007691,,,Cc1nc(/C=C(\CO)[C@@H]2C[C@@H]3O[C@@H]3CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O2)cs1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007691_numbered.png,2026-03-19 06:58:18.263295
7777,ML00000606,CHEMBL3628310,,CC(C)[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)NCc1ccccc1CC(=O)O2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7778,ML00000173,CHEMBL194867,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2C[C@@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00000173_numbered.png,2026-03-19 06:58:18.314870
7779,ML00000651,CHEMBL3628307,,CC(C)[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)NC1CCC(CC1)C(=O)O2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7780,ML00001141,CHEMBL3970623,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1cc(F)c(OC[C@H](O)C3CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7781,ML00000244,CHEMBL146250,,C/C=C1\NC(=O)[C@@H](CS)NC(=O)[C@@H](C(C)C)NC(=O)C[C@@H](/C=C/CCS)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7782,ML00002740,,,CCC(=O)O[C@@H]1CC(=O)O[C@@H](C)C/C(O)=C\C=C/C[C@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@H](C)[C@@H](O[C@H]3C[C@](C)(O)[C@H](OC(=O)CC(C)C)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 5, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002740_numbered.png,2026-03-19 06:58:18.382434
7783,ML00000279,CHEMBL3622730,,C/C=C1\NC(=O)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCSC(=O)CCCCCCC)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7784,ML00008122,,,CC1CCC/C=C/CCC(O)CCC(O)/C=C/C(=O)O1,standard_macrolactone,16.0,,,success,,3.0,"[3, 11, 14]",ring_size_16/standard/numbered/ML00008122_numbered.png,2026-03-19 06:58:18.417358
7785,ML00009045,,,C#CCCC[C@@H]1NC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(OC)cc2)N(C)C(=O)[C@H]([C@@H](C)CC)OC(=O)[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7786,ML00001049,CHEMBL1553405,,CO[C@@H]1COC(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)CCC[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7787,ML00000720,CHEMBL502895,CRYPTOPHYCIN 16,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7788,ML00004969,,,CC(C)[C@H](NC(=O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(Br)cc1)NC(=O)[C@@H](C)NC=O)C(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CS(=O)(=O)O)C(=O)N[C@@H]1C(=O)N(C)[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2ccccc2)C(=O)NCC(=O)N[C@H](CC(N)=O)C(=O)O[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7789,ML00004389,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCNc2ccc(OC(C)=O)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004389_numbered.png,2026-03-19 06:58:18.510155
7790,ML00000697,CHEMBL1436444,,Cc1ccc(S(=O)(=O)N[C@@H]2COC(=O)C/C=C\[C@@H](C)[C@@H](NS(=O)(=O)c3ccc(C)cc3)COC(=O)C/C=C\[C@H]2C)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7791,ML00000357,CHEMBL3317818,,CC(C)(C)OC(=O)n1cnc(C[C@@H]2NC(=O)[C@]3(C)CSC(=N3)c3csc(n3)CNC(=O)C[C@@H](/C=C/CCS)OC2=O)c1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7792,ML00009010,,,CCC[C@H]1C[C@@H]2CC[C@@H](O2)[C@H](C)C(=O)O[C@@H]([C@H](C)[C@H]2CC[C@@H](C[C@@H](CCC)N(C)C)O2)[C@H](C)[C@@H]2CC[C@@H](O2)[C@@H](C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7793,ML00002729,,,CCC(=O)O[C@H]1CC(=O)O[C@H](C)C[C@@H]2O[C@@H]2/C=C\[C@H](O)[C@@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3CO[C@H](C)[C@@H](OC(=O)CC(C)C)[C@]3(C)O)[C@@H](N(C)C)[C@@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002729_numbered.png,2026-03-19 06:58:18.578221
7794,ML00009196,,,C=CCOC[C@H]1/C=C(C)/C=C/C(=O)[C@H](C)CC(C=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O)CC(=O)O[C@@H]1CC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009196_numbered.png,2026-03-19 06:58:18.629389
7795,ML00005771,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2cccnc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005771_numbered.png,2026-03-19 06:58:18.683597
7796,ML00000901,CHEMBL533772,,COC1=CC(C)=C[C@@H](C)[C@@H](O)[C@H](C)CC(C)=CC=C[C@H](OC)[C@@H](C(C)C(O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00000901_numbered.png,2026-03-19 06:58:18.730772
7797,ML00001305,CHEMBL1436846,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H](O[C@H]2O[C@@H](C)[C@@H](O[C@@H]3C[C@](C)(O)[C@H](OC(=O)CC)[C@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001305_numbered.png,2026-03-19 06:58:18.779625
7798,ML00002309,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(OC(=O)CC(C)C)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002309_numbered.png,2026-03-19 06:58:18.827279
7799,ML00006530,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOCCc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006530_numbered.png,2026-03-19 06:58:18.880413
7800,ML00004812,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](C/C=C/c4ccc5ccccc5c4)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7801,ML00009077,,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)C(=O)/C=C/[C@H](C)C(O)C(C)C)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009077_numbered.png,2026-03-19 06:58:18.934756
7802,ML00000405,CHEMBL3410857,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](c3ccc([N+](=O)[O-])cc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7803,ML00010941,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010941_numbered.png,2026-03-19 06:58:18.993007
7804,ML00003888,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3[C@H](CC=O)C[C@H](C)[C@H](O)/C=C\[C@@H]4O[C@H]4C[C@@H](C)OC(=O)C[C@H](OC(C)=O)[C@@H]3OC)[C@@H](O)[C@@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003888_numbered.png,2026-03-19 06:58:19.039846
7805,ML00007031,,,O=C1CCCCCCCCCCC2(CCCO1)N=N/C(=N/c1ccccc1Br)S2,standard_macrolactone,16.0,,,success,,0.0,[],ring_size_16/standard/numbered/ML00007031_numbered.png,2026-03-19 06:58:19.058698
7806,ML00000475,CHEMBL1354988,,CCC1OC(=O)C[C@H](O)C(C)[C@@H](O[C@@H]2OC(C)C(O)C(N(C)C)C2O)C(CCN2CC(C)CC(C)C2)CC(C)C(=O)/C=C/C(C)=C\[C@@H]1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00000475_numbered.png,2026-03-19 06:58:19.110332
7807,ML00002293,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/[C@@H]2O[C@@H]2C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002293_numbered.png,2026-03-19 06:58:19.156366
7808,ML00000303,CHEMBL1326015,,CO[C@@H]1[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@H](CC=O)[C@H]1O[C@H]1O[C@@H](C)[C@@H](O[C@@H]2C[C@](C)(O)[C@H](OC(=O)CC(C)C)[C@H](C)O2)[C@@H](N(C)C)[C@@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00000303_numbered.png,2026-03-19 06:58:19.202121
7809,ML00009861,,,C=C/C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@@H](C)N(C)C(=O)[C@@H]2CC[C@@H](CC)N2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7810,ML00010985,,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](C(C)C)NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7811,ML00005436,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=N\OCCCCc2ccc3ncccc3c2)/C=C/C(C)=C/C1CO[C@@H]1C[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005436_numbered.png,2026-03-19 06:58:19.270055
7812,ML00009552,,,CCCC[C@H](C[C@H]1CC[C@@H]([C@H](CC)[C@@H]2OC(=O)[C@@H](C)[C@H]3CC[C@@H](C[C@@H](CCC)OC(=O)[C@@H](C)[C@H]4CC[C@H](O4)[C@H]2C)O3)O1)N(C)C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7813,ML00009406,,,CO[C@@H]1[C@H](OC[C@@H]2[C@H](C)OC(=O)/C=C\[C@H](C)[C@H](O[C@H]3O[C@H](C)C[C@@]4(OC(=O)O[C@H]4C)[C@H]3O)[C@H](C)C[C@@](C)(O)C(=O)/C=C\[C@H]3O[C@@H]32)O[C@@H](C)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009406_numbered.png,2026-03-19 06:58:19.334299
7814,ML00009284,,,C=CCNC(=O)OC[C@H]1/C=C(C)/C=C/C(=O)[C@H](C)CC(C=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O)CC(=O)O[C@@H]1CC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009284_numbered.png,2026-03-19 06:58:19.396023
7815,ML00004119,,,COc1ccc(C(=O)O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)cc1,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004119_numbered.png,2026-03-19 06:58:19.447506
7816,ML00005793,,,C=C(C=O)[C@H]1C[C@@H](C)[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)/C=C\C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@H](OC)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005793_numbered.png,2026-03-19 06:58:19.497662
7817,ML00002036,CHEMBL2425897,,C/C1=C\C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C)CC1,standard_macrolactone,16.0,,,success,,10.0,"[3, 6, 9, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00002036_numbered.png,2026-03-19 06:58:19.552659
7818,ML00001249,CHEMBL351974,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)C[C@@H](c3ccccc3)NC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7819,ML00008898,,,CCC[C@H]1C[C@@H]2CC[C@@H](O2)[C@H](C)C(=O)O[C@@H]([C@H](C)[C@H]2CC[C@@H](C[C@@H](CCC)NC)O2)C[C@@H]2CC[C@@H](O2)[C@@H](CC)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7820,ML00001356,CHEMBL86812,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](COCc2ccccc2)NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7821,ML00006710,,,O=C1CCCCCCCCCCC(=NOC(=O)COc2ccc(Cl)cc2)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006710_numbered.png,2026-03-19 06:58:19.603467
7822,ML00000628,CHEMBL3628315,,CC(C)[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)NCc1cc(-c3ccccc3)ccc1CC(=O)O2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7823,ML00010264,,,CCCCCCCCCCCC[C@@H]1CCCCCCCCC(=O)OC[C@H]2O[C@@H](O1)[C@H](O)[C@@H](O)[C@@H]2O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7824,ML00003539,,,CC[C@@H](C)[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)/C=C/CCCCCCc2ccc(O)c(Br)c2)[C@@H](C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7825,ML00001306,CHEMBL1908336,MIDECAMYCIN,CCOC(=O)[C@@H]1CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001306_numbered.png,2026-03-19 06:58:19.687831
7826,ML00008496,,,CCCCON=C1CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00008496_numbered.png,2026-03-19 06:58:19.716262
7827,ML00010971,,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](C(C)C)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7828,ML00000397,CHEMBL4069575,,CCc1cc2ccc1CCOC(=O)Nc1ccc(S(=O)(=O)C(C)C)c(c1)CN(C)C(=O)[C@@H]2Nc1cccc(C(N)=O)c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7829,ML00000149,CHEMBL194426,,C/C(=C\c1ccc(C)cn1)[C@@H]1C[C@@H]2C[C@@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)CCC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 6, 10, 11, 12, 13, 14, 14]",ring_size_16/standard/numbered/ML00000149_numbered.png,2026-03-19 06:58:19.792378
7830,ML00008798,,,CC[C@H](O)[C@@H]1C/C=C\C/C=C\CCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,1.0,[3],ring_size_16/standard/numbered/ML00008798_numbered.png,2026-03-19 06:58:19.825125
7831,ML00009391,,,C/C=C/C=C/C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)[C@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7832,ML00002311,,,CCCC(=O)O[C@@H]1[C@@H](C)O[C@@H](O[C@H]2[C@H](C)O[C@H](O[C@H]3[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C\[C@H]4O[C@H]4C[C@@H](C)OC(=O)C[C@@H](OC(=O)CC)[C@H]3OC)[C@@H](O)[C@@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002311_numbered.png,2026-03-19 06:58:19.892876
7833,ML00003769,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003769_numbered.png,2026-03-19 06:58:19.967191
7834,ML00007493,,,C/C(=C\c1csc(C)n1)[C@@H]1C/C=C\CCCC[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,7.0,"[3, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007493_numbered.png,2026-03-19 06:58:20.024246
7835,ML00008971,,,CO[C@H]1[C@@H](O)CC(=O)O[C@@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@H](CC=O)[C@H]1O[C@H]1O[C@@H](C)[C@H](O[C@H]2C[C@@](C)(O)[C@H](O)[C@@H](C)O2)[C@@H](N(C)C)[C@@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00008971_numbered.png,2026-03-19 06:58:20.085001
7836,ML00000001,CHEMBL94657,PATUPILONE,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00000001_numbered.png,2026-03-19 06:58:20.151714
7837,ML00007689,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H](Cl)[C@H](O)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,10.0,"[3, 5, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007689_numbered.png,2026-03-19 06:58:20.217470
7838,ML00006629,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O)[C@@H]([C@H](C)O)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006629_numbered.png,2026-03-19 06:58:20.280284
7839,ML00006686,,,C[C@@H]1CCC[C@H]([C@@H]2CNC(N)=N2)C(=O)OC[C@H](C)CCC[C@H]([C@@H]2CNC(N)=N2)C(=O)OC1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7840,ML00000360,CHEMBL411694,"3-DEOXY-2,3-DIDEHYDRO-EPO A",C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)/C=C/C(=O)O1,standard_macrolactone,16.0,,,success,,7.0,"[3, 10, 11, 12, 13, 14, 14]",ring_size_16/standard/numbered/ML00000360_numbered.png,2026-03-19 06:58:20.344858
7841,ML00007188,,,CCc1nc(/C=C(\C)[C@H]2C[C@H]3O[C@H]3CCC[C@@H](C)[C@@H](O)[C@H](C)C(=O)C(C)(C)[C@H](O)CC(=O)O2)cs1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007188_numbered.png,2026-03-19 06:58:20.395652
7842,ML00003542,,,C/C=C\C=C\C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7843,ML00009846,,,CO/C1=C/C(C)=C\[C@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@@H](C)[C@@]2(O)C[C@@H](OC)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009846_numbered.png,2026-03-19 06:58:20.457091
7844,ML00006372,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)/C(C)=C/C)C(C)C)[C@@H](C)OC(=O)[C@H](CCCc2ccc(O)cc2)NC(=O)[C@@H](CCC(=O)OC)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7845,ML00004166,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(CCCN(C)C)C(=O)CNC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004166_numbered.png,2026-03-19 06:58:20.525048
7846,ML00009359,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@](C)(O)/C=C\c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7847,ML00007178,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007178_numbered.png,2026-03-19 06:58:20.587685
7848,ML00009091,,,CC[C@@H]1O[C@](O)([C@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(C)=C\C(C)=C/[C@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H]2OC)C[C@H](O)[C@@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009091_numbered.png,2026-03-19 06:58:20.644118
7849,ML00008847,,,COc1c(Cl)cc(C[C@H]2NC(=O)/C=C\C[C@@H]([C@H](C)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7850,ML00002094,CHEMBL59732,,O=C(NC(Cc1ccccc1)C(O)CN1CCCCCCCCC/C=C/CCOC1=O)O[C@H]1CO[C@H]2OCC[C@@H]12,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7851,ML00009602,,,C/C=C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H]2OC)C[C@@H](O)[C@@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009602_numbered.png,2026-03-19 06:58:20.714624
7852,ML00007276,,,CC1=C2Cc3cc(ccc3O)C(=O)OC(C)(C)[C@H](Br)CC[C@]3(C)O[C@H]3CC[C@]2(C)[C@@H](Br)CC1,standard_macrolactone,16.0,,,success,,5.0,"[3, 3, 4, 7, 11]",ring_size_16/standard/numbered/ML00007276_numbered.png,2026-03-19 06:58:20.752142
7853,ML00009863,,,CC[C@H]1CC[C@H]2C(=O)N(C)[C@H](C)C(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(=O)OC[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)/C=C/C=C/O)C(=O)N12,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7854,ML00000593,CHEMBL3628317,,CC(C)[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)NCc1[nH]c3ccccc3c1CC(=O)O2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7855,ML00003575,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=N/OCc2ccccc2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003575_numbered.png,2026-03-19 06:58:20.822978
7856,ML00009525,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CCCCCC2)C[C@@H](C)C(=O)/C=C/[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009525_numbered.png,2026-03-19 06:58:20.887638
7857,ML00004556,,,CCCO[C@@H]1[C@@H](N(C)C)[C@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@H](CC)[C@@H](CO[C@@H]2O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]2OC)/C=C(C)/C=C/C(=O)[C@H](C)C[C@@H]1CCN1C(=O)c2ccccc2C1=O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004556_numbered.png,2026-03-19 06:58:20.955561
7858,ML00000267,CHEMBL2436594,,CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(co2)C2=N[C@@](C)(CS2)C(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7859,ML00004707,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O/C=C\Cc3cnc4ccccc4c3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004707_numbered.png,2026-03-19 06:58:21.022823
7860,ML00007642,,,Cc1ccc(OC(C)(C)C(=O)ON=C2CCCCCCCCCCC(=O)OCCC2)cc1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00007642_numbered.png,2026-03-19 06:58:21.047549
7861,ML00001185,CHEMBL3967595,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1cc(F)c(S(=O)(=O)C(C)C)c(c1)CN(C)C(=O)[C@@H]2Nc1cc2ccnc(N)c2cc1F,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7862,ML00000753,CHEMBL506269,CRYPTOPHYCIN 175,COc1c(Cl)cc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7863,ML00006595,,,Cc1ccc(S(=O)(=O)NC2CCCCCCCCCCC(=O)OC(C)CC2)cc1,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/ML00006595_numbered.png,2026-03-19 06:58:21.087663
7864,ML00002008,CHEMBL85272,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccc(O)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7865,ML00010946,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010946_numbered.png,2026-03-19 06:58:21.146036
7866,ML00010100,,,CC[C@H]1C[C@@H](C)C(=O)/C=C\[C@]2(C)O[C@H]2[C@H](C)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010100_numbered.png,2026-03-19 06:58:21.197964
7867,ML00008866,,,C=C=CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@@H](C)N(C)C(=O)[C@@H]2CC[C@@H](CC)N2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7868,ML00010788,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010788_numbered.png,2026-03-19 06:58:21.255681
7869,ML00007079,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)C(=O)[C@@H](C)C[C@@H](C)[C@H](O)/C=C\C=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00007079_numbered.png,2026-03-19 06:58:21.303107
7870,ML00000062,CHEMBL3622726,,C/C=C1\NC(=O)[C@H](CS)NC(=O)[C@@H](C(C)C)NC(=O)C[C@@H](/C=C/CCS)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7871,ML00002312,,,CCC(=O)O[C@@H]1CC(=O)O[C@@H](C)C/C=C\C=C/[C@H](O)[C@@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3O[C@H](C)[C@H](OC(=O)C(C)C)[C@@](C)(O)[C@@H]3O)[C@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002312_numbered.png,2026-03-19 06:58:21.360912
7872,ML00003721,,,CCC[C@@H](C[C@H]1CC[C@@H]([C@H](CC)[C@@H]2OC(=O)[C@@H](CC)[C@H]3CC[C@@H](C[C@@H](CCC)OC(=O)[C@@H](CC)[C@H]4CC[C@H](O4)[C@H]2C)O3)O1)N(C)C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7873,ML00001330,CHEMBL99856,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H]3O[C@H]3c3ccc(CO)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7874,ML00004880,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)OCCC(CCCc4ccnc5ccccc45)CN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7875,ML00002037,CHEMBL2425899,,C/C1=C/C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)CC1,standard_macrolactone,16.0,,,success,,10.0,"[3, 6, 9, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00002037_numbered.png,2026-03-19 06:58:21.439198
7876,ML00005234,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=N/OCCCOc2ccc3ncccc3c2)/C=C/C(C)=C/C1CO[C@@H]1C[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005234_numbered.png,2026-03-19 06:58:21.496729
7877,ML00005485,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005485_numbered.png,2026-03-19 06:58:21.550872
7878,ML00009532,,,CCO[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009532_numbered.png,2026-03-19 06:58:21.597179
7879,ML00009837,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CCN(C)CC2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009837_numbered.png,2026-03-19 06:58:21.648796
7880,ML00002329,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](C/C=C/C(=O)OC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002329_numbered.png,2026-03-19 06:58:21.700410
7881,ML00008403,,,CC(=O)C[C@@H]1CC[C@H](O)/C=C\C(=O)O[C@H](CC(C)=O)CC[C@H](O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7882,ML00005632,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCN2C(=O)c3ccccc3C2=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005632_numbered.png,2026-03-19 06:58:21.766185
7883,ML00002623,,,CCC(=O)O[C@H]1[C@H](C)O[C@H](O[C@@H]2[C@H](C)O[C@H](O[C@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C/C=C\C=C/C(=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002623_numbered.png,2026-03-19 06:58:21.820265
7884,ML00003890,,,CCC(=O)OC1CC(=O)OC(C)CC2OC2/C=C\C(O)C(C)CC(CC=O)C(OC2OC(C)C(OC3CC(C)(O)C(OC(C)=O)C(C)O3)C(N(C)C)C2O)C1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003890_numbered.png,2026-03-19 06:58:21.876930
7885,ML00010240,,,C[C@@]12[C@H]3C[C@@H](O[C@@H]4[C@@H]5O[C@]5(C)CC[C@@]41COC(=O)[C@@H]1O[C@@]14CCO[C@]1(/C=C\C=C/C(=O)O3)[C@@H](O)C(=O)O[C@@H]14)[C@]21CO1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7886,ML00004851,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)OCCC(/C=C/Cc4ccc5ncccc5c4)CN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7887,ML00003786,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003786_numbered.png,2026-03-19 06:58:21.954479
7888,ML00002727,,,CCC(=O)O[C@H]1CC(=O)O[C@H](C)C[C@@H]2O[C@@H]2/C=C\[C@H](O)[C@@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](OC(=O)CC(C)C)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002727_numbered.png,2026-03-19 06:58:22.012245
7889,ML00003679,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCO)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003679_numbered.png,2026-03-19 06:58:22.072527
7890,ML00009229,,,COc1c(Cl)cc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7891,ML00008135,,,C[C@@H]1OC(=O)CC[C@@H](O)[C@H](C)OC(=O)C[C@@H](C)OC(=O)/C=C\[C@H]1O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7892,ML00006863,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006863_numbered.png,2026-03-19 06:58:22.144984
7893,ML00006211,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=N/OCCCc2ccc3ncccc3c2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006211_numbered.png,2026-03-19 06:58:22.207335
7894,ML00002007,CHEMBL313947,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccc(O)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7895,ML00003529,,,CCCC/C=C/C(=O)N[C@@H](Cc1cccc(F)c1)C(=O)N[C@@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)C2(CCC2)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7896,ML00008980,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00008980_numbered.png,2026-03-19 06:58:22.280331
7897,ML00001960,CHEMBL315267,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2cccnc2)NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7898,ML00005664,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc(CO)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005664_numbered.png,2026-03-19 06:58:22.350476
7899,ML00004280,,,CCC(=O)O[C@@H]1[C@@H](C)O[C@@H](O[C@H]2[C@H](C)O[C@H](O[C@@H]3[C@@H](OC)[C@H](OC(C)=O)CC(=O)O[C@H](C)C[C@H]4O[C@H]4/C=C\C(=O)[C@H](C)C[C@@H]3CC=O)[C@@H](O)[C@@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004280_numbered.png,2026-03-19 06:58:22.404726
7900,ML00003827,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003827_numbered.png,2026-03-19 06:58:22.465421
7901,ML00006252,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCOC(C(F)(F)F)C(F)(F)F)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006252_numbered.png,2026-03-19 06:58:22.529363
7902,ML00005692,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccc(CN4CCN(C(=O)OC(C)(C)C)CC4)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7903,ML00008979,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@H](OC)[C@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00008979_numbered.png,2026-03-19 06:58:22.588652
7904,ML00009638,,,CC[C@@H]1OC(=O)C[C@@H](O)[C@H](C)[C@H](O[C@H]2O[C@H](C)[C@H](O[C@@H]3CC[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@@H]2O)[C@H](CC=O)C[C@H](C)C(=O)/C=C\[C@]2(C)O[C@@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009638_numbered.png,2026-03-19 06:58:22.641240
7905,ML00009756,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(/C=C/c3ccccc3)OC(C)=O)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7906,ML00008850,,,CO[C@H](/C(C)=C/C=C/C(C)=C/c1coc(C)n1)[C@H](C)[C@H]1C[C@@H](O)[C@@]2(C)O[C@H]2/C=C/[C@@H](C)[C@@H]2C[C@@H](CC(=O)O2)C[C@H]2O[C@@H]2C(=O)O1,standard_macrolactone,16.0,,,success,,4.0,"[3, 5, 6, 10]",ring_size_16/standard/numbered/ML00008850_numbered.png,2026-03-19 06:58:22.681633
7907,ML00009475,,,CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)C2=N[C@@](C)(CS2)C(=O)N[C@H](Cc2cccc3ccccc23)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7908,ML00009574,,,CCC[C@H]1C[C@@H]2CC[C@@H](O2)[C@H](CC)C(=O)O[C@@H]([C@H](CC)[C@H]2CC[C@@H](C[C@@H](CCC)N(C)C)O2)[C@H](C)[C@@H]2CC[C@@H](O2)[C@@H](C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7909,ML00004891,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)CCCN(CCCCc4ccccc4)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(C)=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7910,ML00000317,CHEMBL3895930,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(C3(C(=O)O)CCOCC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)ncc(F)c2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7911,ML00007003,,,CC1CCC(NS(=O)(=O)c2ccccc2)CCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/ML00007003_numbered.png,2026-03-19 06:58:22.734757
7912,ML00004456,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc(OC)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004456_numbered.png,2026-03-19 06:58:22.794036
7913,ML00007191,,,C/C(=C\c1csc(CO)n1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007191_numbered.png,2026-03-19 06:58:22.846236
7914,ML00003534,,,CC/C=C/C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)[C@H]2CC[C@@H](CC)N2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7915,ML00008988,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(C)CCNC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00008988_numbered.png,2026-03-19 06:58:22.904558
7916,ML00000258,CHEMBL1530445,,CO[C@@H]1COC(=O)CCC[C@H](C)[C@@H](OC)COC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7917,ML00000701,CHEMBL166221,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H]3O[C@@H]3c3ccc(C(=O)c4ccccc4)cc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7918,ML00006854,,,COc1ccc(OCC(=O)ON=C2CCCCCCCCCCC(=O)OCCC2)cc1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006854_numbered.png,2026-03-19 06:58:22.944396
7919,ML00005509,,,C[C@@H]1OC(=O)[C@@H](c2cc(O)cc(O)c2)NC(=O)[C@H](c2cc(O)cc(O)c2)NC(=O)[C@@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]1NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc[nH]1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7920,ML00009429,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COCc1ccccc1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009429_numbered.png,2026-03-19 06:58:23.011549
7921,ML00004520,,,CC(C)CCCCCCCC(O)CC(=O)NC(CS(=O)(=O)O)C(=O)NC(CC(C)C)C(=O)NCCCC(=O)NC(Cc1c[nH]cn1)C(=O)NC(C)C(=O)NC1C(=O)NC(C(C)O)C(=O)NC(Cc2c[nH]cn2)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)OC1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7922,ML00002626,,,CCC(=O)O[C@@H]1CC(=O)O[C@@H](C)C/C=C\C=C/C(=O)[C@@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@@H](C)[C@H](O[C@@H]3C[C@@](C)(O)[C@H](OC(=O)CC)[C@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002626_numbered.png,2026-03-19 06:58:23.077156
7923,ML00009816,,,CC[C@@H]1OC(=O)C[C@H](O)[C@@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@@H](O[C@H]3CCC(=O)[C@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\[C@H]2O[C@@H]2[C@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009816_numbered.png,2026-03-19 06:58:23.131861
7924,ML00001925,CHEMBL401181,,C[C@@]1(N)Cc2cccc(c2F)CC[C@H](c2ccc(F)cc2)NC(=O)c2cc(cc(-c3ccccc3C#N)c2)COC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7925,ML00002033,CHEMBL3426553,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]2CCC[C@@H](C(=O)C(C)(C)[C@@H](O)CC(=O)O1)[C@H]2O,standard_macrolactone,16.0,,,success,,7.0,"[3, 6, 11, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00002033_numbered.png,2026-03-19 06:58:23.188601
7926,ML00006142,,,CCC1OC(=O)CC(OC(C)=O)C(C)C(OC2OC(C)C(OC3CC(C)(O)C(O)C(C)O3)C(N(C)C)C2O)C(CC=O)CC(C)C(=O)/C=C\C(C)=C/C1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006142_numbered.png,2026-03-19 06:58:23.252332
7927,ML00004909,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)OC(C)C/C=C/N(CCCCc4ccccc4)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(C)=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7928,ML00004570,,,CC[C@@H]1[C@@H](C)O[C@@](OC)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C=C/C=C/[C@H](C)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]3(OC)C[C@@H](O[C@H]4C[C@H](O)[C@H](O)[C@H](C)O4)[C@H](C)[C@@H](C)O3)OC(=O)/C=C/C=C/[C@@H]2C)C[C@H]1O[C@H]1C[C@H](O)[C@H](O)[C@H](C)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7929,ML00010526,,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](N2CCCC2)NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7930,ML00002490,,,C[C@@H]1NC(=O)[C@@H]2CCCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)/C=C/CCCCC(=O)O)[C@H](C)OC(=O)[C@@H]2C[C@@H](C)CN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7931,ML00009791,,,CC[C@@H]1OC(=O)/C=C\[C@H](C)[C@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@H](C)C(=O)/C=C\C=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@H](O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009791_numbered.png,2026-03-19 06:58:23.341014
7932,ML00007993,,,O=C1CCCCCCCCCCC(=O)OCCO1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7933,ML00003487,,,CO/C1=C/C(C)=C\[C@@H](C)[C@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC(=O)/C=C/C(=O)O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00003487_numbered.png,2026-03-19 06:58:23.399884
7934,ML00001013,CHEMBL93904,,C/C1=C/C[C@@H](c2ccc3c(c2)ncn3C)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00001013_numbered.png,2026-03-19 06:58:23.453554
7935,ML00006885,,,COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OCCCCCCC(=O)N1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7936,ML00000165,CHEMBL3622727,,C/C=C1\NC(=O)c2csc(n2)[C@@H](C(C)C)NC(=O)C[C@@H](/C=C/CCS)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7937,ML00003740,,,CCCCC[C@@H]1OCO[C@]2(C)/C=C(C)\C=C/C(=O)O[C@H]([C@H](C)[C@H](O)[C@@H](C)C(=O)/C=C/[C@H](C)[C@H](C)O)[C@@H](OC)/C=C\C=C(\C)C[C@H]1[C@@H]2O,standard_macrolactone,16.0,,,success,,6.0,"[3, 4, 8, 11, 12, 14]",ring_size_16/standard/numbered/ML00003740_numbered.png,2026-03-19 06:58:23.512372
7938,ML00000389,CHEMBL3901391,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(S(=O)(=O)C3CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1cc2ccnc(N)c2cc1F,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7939,ML00010718,,,CC(=O)O[C@H]1C[C@H](C[C@@H](C)OC(C)=O)OC(=O)[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](OC(C)=O)C[C@H](C[C@@H](C)OC(C)=O)OC(=O)[C@@H](C)[C@@H](O)[C@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7940,ML00007184,,,C/C(=C\c1csc(C)n1)[C@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)C(O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007184_numbered.png,2026-03-19 06:58:23.577082
7941,ML00004860,,,CCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@@H](C/C=C/c4cnc5ccccc5c4)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(=O)CC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7942,ML00010822,,,CC[C@H]1/C=C\[C@@H]([C@@H](O)C=C(C)C)OC(=O)/C(C)=C\[C@@H]2C(=O)NC3=CC(=O)c4c(cc(C)c(O)c4C(=O)CC1)[C@]32O,standard_macrolactone,16.0,,,success,,5.0,"[3, 6, 9, 13, 16]",ring_size_16/standard/numbered/ML00010822_numbered.png,2026-03-19 06:58:23.623602
7943,ML00006600,,,CC[C@H]1C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H](C)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006600_numbered.png,2026-03-19 06:58:23.671664
7944,ML00006904,,,CC[C@H]1OC(=O)C[C@H](O)[C@H](C)C(=O)[C@@H](C)C[C@@H](C)C(=O)/C=C\C=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006904_numbered.png,2026-03-19 06:58:23.716582
7945,ML00007664,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007664_numbered.png,2026-03-19 06:58:23.772233
7946,ML00010913,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\[C@]2(C)O[C@H]2[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010913_numbered.png,2026-03-19 06:58:23.828431
7947,ML00002577,,,CO/C1=C/C(C)=C\[C@@H](C)[C@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@]2(O)C[C@@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00002577_numbered.png,2026-03-19 06:58:23.877115
7948,ML00001780,CHEMBL394225,,CC1CCc2cccc(c2)C[C@@](C)(N)C(=O)OCc2cc(cc(N(C)S(C)(=O)=O)c2)CC1,standard_macrolactone,16.0,,,success,,3.0,"[9, 16, 16]",ring_size_16/standard/numbered/ML00001780_numbered.png,2026-03-19 06:58:23.906716
7949,ML00007066,,,O=C1CCCCCCCCCCC(=NOCc2ccccc2)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00007066_numbered.png,2026-03-19 06:58:23.928743
7950,ML00000120,CHEMBL3951940,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(-c3ccnn3C)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
7951,ML00007260,,,CC1=C2Cc3cc(ccc3O)C(=O)OC(C)(C)[C@@H](O)CC[C@](C)(O)[C@H](Br)CC[C@]2(C)[C@@H](Br)CC1,standard_macrolactone,16.0,,,success,,7.0,"[3, 3, 4, 7, 7, 8, 11]",ring_size_16/standard/numbered/ML00007260_numbered.png,2026-03-19 06:58:23.976915
7952,ML00007495,,,Cc1nc(/C=C/[C@@H]2C/C=C\CCC[C@@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O2)cs1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007495_numbered.png,2026-03-19 06:58:24.021756
7953,ML00009995,,,CC(C)[C@@H]1NC(=O)[C@@H](NC(=O)c2ccc(O)cc2)[C@@H](C)OC(=O)[C@@H]2CCCCN2C(=O)[C@@H]2CCCCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7954,ML00005546,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005546_numbered.png,2026-03-19 06:58:24.077016
7955,ML00000983,CHEMBL290814,BAFILOMYCIN A1,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00000983_numbered.png,2026-03-19 06:58:24.132462
7956,ML00008123,,,C[C@@H]1CCCCCCCCC[C@H](O)C(=O)/C=C/C(=O)O1,standard_macrolactone,16.0,,,success,,3.0,"[3, 13, 14]",ring_size_16/standard/numbered/ML00008123_numbered.png,2026-03-19 06:58:24.161839
7957,ML00007141,,,C/C(=C\c1csc(C)n1)[C@@H]1C/C=C\CCC(=O)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 9, 10, 11, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00007141_numbered.png,2026-03-19 06:58:24.206695
7958,ML00005327,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc(-c3ccccc3)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005327_numbered.png,2026-03-19 06:58:24.262927
7959,ML00002546,,,CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](CCC)NC(=O)[C@@H]2CCCCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7960,ML00005592,,,CC[C@H]1OC(=O)C[C@@H](O)[C@@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](O)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@H](CC=O)C[C@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO[C@H]1C[C@@H](OC)[C@H](O)[C@@H](C)O1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005592_numbered.png,2026-03-19 06:58:24.332039
7961,ML00006615,,,CO[C@H]1CCCCCCCCC[C@@H](C)OC(=O)C(S(=O)(=O)c2ccccc2)CC1=O,standard_macrolactone,16.0,,,success,,4.0,"[3, 13, 14, 16]",ring_size_16/standard/numbered/ML00006615_numbered.png,2026-03-19 06:58:24.370813
7962,ML00006213,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=N/OCCCc2ccc3ncccc3c2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006213_numbered.png,2026-03-19 06:58:24.434145
7963,ML00003041,,,CC[C@@H]1C[C@@H]2C[C@H](O[C@@H]3OC[C@@H](OC)[C@H](OC)[C@H]3OC)C(C)(C)[C@H](CC(=O)O[C@H](CC)C[C@@H]3C[C@H](O[C@@H]4OC[C@@H](OC)[C@H](OC)[C@H]4OC)C(C)(C)[C@H](CC(=O)O1)O3)O2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7964,ML00003901,,,CCC(=O)O[C@@H]1CC(=O)O[C@@H](C)C/C=C\C=C/[C@H](O)[C@@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@H](C)[C@@H](O[C@H]3C[C@](C)(O)[C@H](OC(C)=O)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003901_numbered.png,2026-03-19 06:58:24.499614
7965,ML00003498,,,CC[C@H]1OC(=O)CC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H](O)[C@@H](N(C)C)[C@H]2O)[C@H]2C[C@H](O)[C@@](C)(C2)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@@H](C)[C@@H](O)[C@@H](OC)[C@@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 6, 9, 10, 13, 14, 15]",ring_size_16/standard/numbered/ML00003498_numbered.png,2026-03-19 06:58:24.555223
7966,ML00001235,CHEMBL3251854,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001235_numbered.png,2026-03-19 06:58:24.606022
7967,ML00003788,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@@]2(OC)C[C@@H](OC(C)=O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00003788_numbered.png,2026-03-19 06:58:24.658331
7968,ML00010956,,,CC[C@H]1OC(=O)CC[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 6, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00010956_numbered.png,2026-03-19 06:58:24.712284
7969,ML00009316,,,CCC[C@@H]1OC(=O)[C@H](C)CNC(=O)[C@@H](Cc2ccc(OC)c(Cl)c2)NC(=O)/C=C\C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7970,ML00006915,,,CC[C@@H]1OC(=O)/C=C\[C@H](C)[C@H](O)[C@H](C)C[C@@H](C)C(=O)/C=C\C=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00006915_numbered.png,2026-03-19 06:58:24.767547
7971,ML00008817,,,COc1ccc(C[C@H]2NC(=O)/C=C\C[C@@H]([C@H](C)[C@@H]3O[C@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7972,ML00009464,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(C)CCCNC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009464_numbered.png,2026-03-19 06:58:24.834244
7973,ML00005516,,,CC[C@H]1OC(=O)C[C@@H](O)C(C)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](C=O)C[C@@H](C)[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)/C=C\C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005516_numbered.png,2026-03-19 06:58:24.896842
7974,ML00007189,,,CSc1nc(/C=C(\C)[C@@H]2C[C@@H]3O[C@]3(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O2)cs1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007189_numbered.png,2026-03-19 06:58:24.952906
7975,ML00006428,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(OC3CC(C)(O)C(O)C(C)O3)C(N(C)C)C2O)[C@@H](CCN)C[C@@H](C)C(=O)/C=C/C(C)=C/C1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006428_numbered.png,2026-03-19 06:58:25.014468
7976,ML00000602,CHEMBL3317811,,C[C@@]12CSC(=N1)c1csc(n1)CNC(=O)C[C@@H](/C=C/CCS)OC(=O)[C@H](Cc1ccc(O)cc1)NC2=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7977,ML00010628,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](CCCc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7978,ML00002915,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=O)/C=C/C=C/[C@@H]1CSC1CCCCC1,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002915_numbered.png,2026-03-19 06:58:25.087970
7979,ML00006953,,,CC1CCC(NS(=O)(=O)c2cccs2)CCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/ML00006953_numbered.png,2026-03-19 06:58:25.118699
7980,ML00007012,,,O=C1CCCCCCCCCCC(=NOCc2ccc(Cl)cc2)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00007012_numbered.png,2026-03-19 06:58:25.142592
7981,ML00004898,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](CCCc4ccnc5ccccc45)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7982,ML00005548,,,CCC(=O)O[C@H]1[C@H](C)O[C@H](O[C@H]2[C@H](C)O[C@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C/C=C\C=C/[C@@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@@H](O)[C@@H]2N(C)C)[C@@H](O)[C@]1(C)OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005548_numbered.png,2026-03-19 06:58:25.202319
7983,ML00006374,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)/C(C)=C/C)C(C)C)[C@@H](C)OC(=O)[C@H](CCCCc2ccc(O)cc2)NC(=O)[C@@H](CCC(=O)O)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7984,ML00007641,,,Cc1cccc(OC(C)C(=O)ON=C2CCCCCCCCCCC(=O)OCCC2)c1C,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00007641_numbered.png,2026-03-19 06:58:25.234505
7985,ML00007685,,,CCC[C@]1(C)C[C@H]2OC(=O)/C=C\[C@@H](C)CC(=O)O[C@@H](CC(C)=O)[C@H](C)/C=C(/C)CC[C@@H]2O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7986,ML00008456,,,CC[C@H]1OC(=O)CCC/C=C\C/C=C\C/C=C\[C@H]2[C@H](O)[C@@H](O)C[C@H]12,standard_macrolactone,16.0,,,success,,1.0,[3],ring_size_16/standard/numbered/ML00008456_numbered.png,2026-03-19 06:58:25.262557
7987,ML00004882,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCSc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004882_numbered.png,2026-03-19 06:58:25.326554
7988,ML00009975,,,CC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@H](N(C)C)[C@H]2O)[C@H](C)C[C@@H](C)C(=O)/C=C\[C@H]2O[C@@H]2[C@@H]1CO,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009975_numbered.png,2026-03-19 06:58:25.371493
7989,ML00004703,,,CCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](C/C=C/c4ccc(N)nc4)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(=O)CC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7990,ML00003790,,,COC(=O)[C@@H]1C[C@](OC)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@@H]2OC)O[C@H](C(C)C)[C@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00003790_numbered.png,2026-03-19 06:58:25.428140
7991,ML00003770,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCI)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003770_numbered.png,2026-03-19 06:58:25.481644
7992,ML00002323,,,CO[C@@H]1[C@@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@H](CC=O)[C@H]1O[C@@H]1O[C@H](C)[C@H](O[C@@H]2C[C@](C)(O)[C@H](OC(=O)CC(C)C)[C@H](C)O2)[C@@H](N(C)C)[C@@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002323_numbered.png,2026-03-19 06:58:25.528018
7993,ML00001348,CHEMBL3251856,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001348_numbered.png,2026-03-19 06:58:25.574367
7994,ML00000304,CHEMBL2106399,KITASAMYCIN,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00000304_numbered.png,2026-03-19 06:58:25.621640
7995,ML00009377,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC(=O)Nc1ccc(F)c(F)c1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009377_numbered.png,2026-03-19 06:58:25.674456
7996,ML00002307,,,CO[C@H]1[C@@H](OC(C)=O)CC(=O)O[C@H](C)C[C@@H]2O[C@@H]2/C=C\[C@H](O)[C@@H](C)C[C@H](CC=O)[C@@H]1O[C@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@@H](C)O2)[C@@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002307_numbered.png,2026-03-19 06:58:25.724114
7997,ML00002046,CHEMBL235854,,CN(c1cc2cc(n1)CCC(c1ccccc1)CCc1cccc(c1)C[C@@](C)(N)C(=O)OC2)S(C)(=O)=O,standard_macrolactone,16.0,,,success,,3.0,"[9, 16, 16]",ring_size_16/standard/numbered/ML00002046_numbered.png,2026-03-19 06:58:25.756087
7998,ML00001025,CHEMBL92925,,Cc1nc2cc([C@@H]3C[C@@H]4O[C@]4(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O3)ccc2s1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00001025_numbered.png,2026-03-19 06:58:25.804810
7999,ML00006320,,,C[C@H]1C(=O)N[C@H](C)C(=O)N2C[C@H](C)C[C@H]2C(=O)OC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)/C=C/C=C/C=C/C=C/C=C/C(=O)NC2=C(O)CCC2=O)C(=O)N2CCC[C@H]2C(=O)N1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8000,ML00009615,,,CCO[C@@H]1C[C@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@@H]2OC)O[C@H](C(C)C)[C@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009615_numbered.png,2026-03-19 06:58:25.862973
8001,ML00008034,,,O=C1CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00008034_numbered.png,2026-03-19 06:58:25.886847
8002,ML00010528,,,CC(C)C[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)CCN(C)C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8003,ML00003122,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=N/OC/C=C\c2cnc3ccccc3c2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003122_numbered.png,2026-03-19 06:58:25.952559
8004,ML00000265,CHEMBL3622731,,C/C=C1\NC(=O)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCSC(C)=O)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8005,ML00004856,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C/C=C/c4ccnc5ccccc45)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8006,ML00009805,,,CO[C@H]1[C@H](OC[C@H]2/C=C/C=C/C(=O)[C@H](C)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@](O)([C@H](C)O)[C@H]3O)[C@@H](C)/C=C/C(=O)O[C@@H]2C)O[C@H](C)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009805_numbered.png,2026-03-19 06:58:26.016763
8007,ML00010438,,,CC(=O)O[C@H]1C[C@@]23COC(=O)[C@@H]4O[C@@]45CCO/C(=C/C/C=C\C(=O)O[C@@H]4C[C@@H](O[C@@H]2C=C1C)[C@@]1(CO1)[C@]43C)[C@H]5O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8008,ML00001399,CHEMBL3251865,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(C)=O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](OC(C)=O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001399_numbered.png,2026-03-19 06:58:26.071550
8009,ML00000153,CHEMBL193425,,C/C(=C\c1ccc(C)cn1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00000153_numbered.png,2026-03-19 06:58:26.119506
8010,ML00009597,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](OC(=O)CC(C)C)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](OC(C)=O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009597_numbered.png,2026-03-19 06:58:26.164567
8011,ML00003519,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](OC(C)=O)[C@@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC(C)=O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00003519_numbered.png,2026-03-19 06:58:26.211993
8012,ML00009924,,,C/C(=C\c1csc(C)n1)[C@@H]1C/C=C\CCC[C@H](COCc2ccccc2)C(O)[C@@H](C)C(=O)C(C)(C)C(O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00009924_numbered.png,2026-03-19 06:58:26.257519
8013,ML00008437,,,C[C@@H]1CCCCCCCCC[C@@H](OC(=O)CCC(=O)O)C(=O)/C=C\C(=O)O1,standard_macrolactone,16.0,,,success,,3.0,"[3, 13, 14]",ring_size_16/standard/numbered/ML00008437_numbered.png,2026-03-19 06:58:26.285359
8014,ML00005761,,,CCCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/C(=O)[C@@H](C)C[C@@H](CC=O)[C@H](O[C@H]2O[C@H](C)[C@@H](O[C@H]3C[C@](C)(O)[C@H](OC(=O)CC(C)C)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005761_numbered.png,2026-03-19 06:58:26.331055
8015,ML00009080,,,CO[C@H]1/C=C/C=C(\C)C[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C=C(\C)C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)C(=O)/C=C/[C@H](C)[C@H](O)C(C)C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009080_numbered.png,2026-03-19 06:58:26.375580
8016,ML00003889,,,CCC(=O)O[C@H]1CC(=O)O[C@H](C)C[C@@H]2O[C@@H]2/C=C\[C@H](O)[C@@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@H](C)[C@@H](O[C@@H]3C[C@](C)(O)[C@H](OC(C)=O)[C@H](C)O3)[C@H](N(C)C)[C@@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003889_numbered.png,2026-03-19 06:58:26.424128
8017,ML00001101,CHEMBL3979309,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc([C@@H](CC(F)F)C(=O)O)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)ncc(F)c2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8018,ML00005444,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)C[C@H](O)[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)OC[C@H](O)[C@@H]2NC(=O)[C@H](C)N(C)C(=O)CN(C)C(=O)[C@@H]3CC(=O)CN3C(=O)[C@@H](C(C)C)NC2=O)c(N)c1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8019,ML00002325,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C\C=C\C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002325_numbered.png,2026-03-19 06:58:26.486768
8020,ML00003541,,,C/C=C\C=C/C=C\C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8021,ML00004092,,,CCCC/C=C/C(=O)N[C@@H](Cc1c(F)c(F)c(F)c(F)c1F)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](CC)NC(=O)[C@@H]2CCCCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8022,ML00009928,,,CO[C@H]1CCCC[C@@H](c2ccccc2)OC(=O)[C@@H](C)[C@@]2(O)O[C@@H]([C@@H](C)/C=C\[C@H]1OC)[C@@H](C)[C@H](O)[C@H]2OC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8023,ML00003782,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003782_numbered.png,2026-03-19 06:58:26.560115
8024,ML00002130,CHEMBL427884,,CN(C)S(=O)(=O)N(C)c1cc2cc(c1)C(=O)N[C@@H](c1ccccc1)CCc1cccc(c1)C[C@@](C)(N)C(=O)OC2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8025,ML00006617,,,CO[C@H]1CCCCCCCCC[C@@H](C)OC(=O)C(Sc2ccccc2)CC1=O,standard_macrolactone,16.0,,,success,,4.0,"[3, 13, 14, 16]",ring_size_16/standard/numbered/ML00006617_numbered.png,2026-03-19 06:58:26.599379
8026,ML00004543,,,CC(C)C[C@H](NC(=O)[C@@H](CO)NC(=O)C[C@H](O)CCCC[C@H](O)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)N[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8027,ML00008868,,,C/C=C/C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@@H](C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8028,ML00003277,,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8029,ML00000610,CHEMBL3410867,,COc1ccc(C[C@@H]2NC(=O)/C=C/C[C@@H](c3c(F)c(F)c(F)c(F)c3F)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8030,ML00002138,,,CO[C@H]1/C=C\C=C(\C)C[C@H](C)[C@H](O)[C@H](C)/C=C(C)\C=C(\C)C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](OC(=O)/C=C/C2=CC(=O)OC2=O)[C@H](C)[C@@H](C(C)C)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00002138_numbered.png,2026-03-19 06:58:26.675333
8031,ML00010596,,,CN(C)[C@@H]1[C@H](O)[C@H](O)[C@@H](O[C@]23C=CC=C2c2c4ccc(c2Cl)[C@@H](O)COC(=O)CC(N)c2cc(O)c(c(Cl)c2)O[C@H]43)OC1(C)C,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8032,ML00005684,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)C=C(C)C)C(C)C)[C@@H](C)OC(=O)[C@H](CCCc2ccc(O)cc2)NC(=O)[C@@H](CCC(=O)O)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8033,ML00003251,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](OC(=O)c3ccccc3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](OC(C)=O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003251_numbered.png,2026-03-19 06:58:26.737171
8034,ML00010625,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(O)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8035,ML00000383,CHEMBL400530,,CCCN(c1cc2cc(c1)C(=O)N[C@@H](c1ccccc1)CCc1cccc(c1)C[C@@](C)(N)C(=O)OC2)S(C)(=O)=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8036,ML00004664,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc(-c3ccccc3)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004664_numbered.png,2026-03-19 06:58:26.804252
8037,ML00009921,,,COC(=O)C[C@@H]1C/C=C\C(=O)O[C@H]([C@H](C)[C@@H](OC)/C(C)=C/C=C/C(C)=C\c2coc(C)n2)C[C@H](O)[C@@]2(C)O[C@@H]2/C=C\[C@@H](C)[C@H](O)C1,standard_macrolactone,16.0,,,success,,6.0,"[3, 5, 6, 10, 11, 13]",ring_size_16/standard/numbered/ML00009921_numbered.png,2026-03-19 06:58:26.844431
8038,ML00010624,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(=O)CCc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8039,ML00003917,,,CCC(=O)O[C@H]1CC(=O)O[C@@H](C)C/C=C\C=C/[C@H](O[C@@H]2C[C@@H](N(C)C)C[C@@H](C)O2)[C@H](C)C[C@H](CC=O)[C@@H](O[C@@H]2C[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003917_numbered.png,2026-03-19 06:58:26.896338
8040,ML00002574,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCSc2nnnn2C)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002574_numbered.png,2026-03-19 06:58:26.948605
8041,ML00007662,,,C/C(=C\c1csc(C)n1)[C@@H]1C/C=C\C=C/C[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007662_numbered.png,2026-03-19 06:58:26.993296
8042,ML00000065,CHEMBL3593411,,CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2ccnc(c2)CNC(=O)C[C@@H](/C=C/CCS)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8043,ML00002047,CHEMBL524991,BROMOPHYCOLIDE H,C=C1CC[C@H](Br)[C@@]2(C)CC[C@@H](Br)[C@@](C)(O)CC[C@@H](Br)C(C)(C)OC(=O)c3ccc(O)c(c3)C[C@H]12,standard_macrolactone,16.0,,,success,,7.0,"[3, 3, 4, 7, 7, 8, 11]",ring_size_16/standard/numbered/ML00002047_numbered.png,2026-03-19 06:58:27.041270
8044,ML00001413,CHEMBL411325,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)C3(CCCC3)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8045,ML00006429,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCN=[N+]=[N-])C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006429_numbered.png,2026-03-19 06:58:27.107610
8046,ML00007074,,,CCC1CC2CCC(O2)C(C)C(=O)OC(C)CC2CCC(O2)C(C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8047,ML00009627,,,CO[C@H]1[C@@H](O)CC(=O)O[C@H](C)C[C@@H]2O[C@@H]2/C=C\[C@H](O)[C@@H](C)C[C@H](CC=O)[C@@H]1O[C@H]1C[C@H](N(C)C)[C@H](O[C@H]2C[C@](C)(O)[C@@H](OC(C)=O)[C@@H](C)O2)[C@@H](C)O1,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009627_numbered.png,2026-03-19 06:58:27.163423
8048,ML00003582,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COCOCc1ccccc1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003582_numbered.png,2026-03-19 06:58:27.216210
8049,ML00009305,,,CCC[C@@H]1OC(=O)[C@H](C)CNC(=O)[C@@H](Cc2ccc(OC)c(Cl)c2)NC(=O)/C=C\C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8050,ML00010435,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@]56OCC[C@@]7(O[C@H]7C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)[C@H]5O[C@@H](O)[C@@H]6O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8051,ML00003579,,,CC[C@@H](C)[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CCCCCCCCc2ccc(O)c(Br)c2)[C@@H](C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8052,ML00004706,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](OC/C=C/c3cnc4ccccc4c3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004706_numbered.png,2026-03-19 06:58:27.289782
8053,ML00000837,CHEMBL2324843,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@@H](CCN=[N+]=[N-])CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8054,ML00004910,,,CCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@@H](C/C=C/c4cnc(N)c5ccccc45)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(=O)CC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8055,ML00009954,,,CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)C2=N[C@](C)(CS2)C(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8056,ML00001332,CHEMBL318838,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3cccc(C)c3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8057,ML00001697,CHEMBL235853,,CC1CCc2cccc(c2)C[C@@](C)(N)C(=O)OCc2cc(nc(N(C)S(C)(=O)=O)c2)CC1,standard_macrolactone,16.0,,,success,,3.0,"[9, 16, 16]",ring_size_16/standard/numbered/ML00001697_numbered.png,2026-03-19 06:58:27.349385
8058,ML00010439,,,CC(=O)[C@@]12/C=C\C=C/C(=O)O[C@@H]3C[C@H]4O[C@@H]5C=C(C)CC[C@]5(COC(=O)[C@H]5O[C@]5(CCO1)[C@@H]2O)[C@]3(C)[C@]41CO1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8059,ML00006295,,,CCOC(=O)/C=C/C[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](COC2OC(C)C(O)C(OC)C2OC)[C@@H](CC)OC(=O)C[C@@H](NN(C(=O)OCC)C(=O)OCC)[C@H](C)[C@H]1OC1OC(C)C(O)C(N(C)C)C1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006295_numbered.png,2026-03-19 06:58:27.411902
8060,ML00002667,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002667_numbered.png,2026-03-19 06:58:27.460192
8061,ML00006007,,,CC(C)C[C@@H](NC=O)C(=O)N[C@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8062,ML00004145,,,CNCC(=O)NCc1ccc([C@H](Cl)[C@H](O)[C@@H](C)[C@@H]2C/C=C/C(=O)N[C@H](Cc3ccc(OC)c(Cl)c3)C(=O)NCC(C)(C)C(=O)O[C@@H](CC(C)C)C(=O)O2)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8063,ML00009629,,,CC[C@H]1OC(=O)/C=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C/[C@@H]2O[C@H]2[C@]1(O)CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009629_numbered.png,2026-03-19 06:58:27.529580
8064,ML00004114,,,C[C@@H]1NC(=O)[C@@H]2CCCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)/C=C/CC2CC2)[C@H](C)OC(=O)[C@@H]2C[C@@H](C)CN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8065,ML00007502,,,Cc1nc(/C=C/[C@@H]2C[C@@H]3O[C@@H]3CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O2)cs1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007502_numbered.png,2026-03-19 06:58:27.590886
8066,ML00007180,,,CC1=CCC(/C(C)=C/c2csc(C)n2)OC(=O)CC(O)C(C)(C)C(=O)C(C)C(O)C(C)CCC1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007180_numbered.png,2026-03-19 06:58:27.644651
8067,ML00008815,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8068,ML00010951,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010951_numbered.png,2026-03-19 06:58:27.709100
8069,ML00002674,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002674_numbered.png,2026-03-19 06:58:27.757601
8070,ML00000096,CHEMBL3980787,,CCOP(=O)(OCC)c1ccc2cc1CN(C)C(=O)[C@H](Nc1ccc3c(N)nccc3c1)c1ccc(c(C)c1)[C@@H](C)COC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8071,ML00001959,CHEMBL3976650,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(C3CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8072,ML00007663,,,C/C(=C\c1coc(C)n1)[C@@H]1C/C=C\CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007663_numbered.png,2026-03-19 06:58:27.818510
8073,ML00008016,,,O=C1CCCCCCCCCCC(O)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00008016_numbered.png,2026-03-19 06:58:27.843418
8074,ML00009425,,,CC[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)CC/C(C)=C\C=C/[C@@H]2OC)C[C@@H](OC(=O)/C=C/C(=O)O)[C@@H]1C,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 8, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009425_numbered.png,2026-03-19 06:58:27.892181
8075,ML00001800,CHEMBL1526733,,CO[C@@H]1COC(=O)CCC[C@@H](C)[C@H](OC)COC(=O)CCC[C@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8076,ML00002290,,,COC1C(OC(C)=O)CC(=O)OC(C)CC2OC2/C=C\C(=O)C(C)CC(CC=O)C1OC1OC(C)C(OC2CC(C)(O)C(OC(=O)CC(C)C)C(C)O2)C(N(C)C)C1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002290_numbered.png,2026-03-19 06:58:27.948808
8077,ML00002408,,,C=C1Oc2cc(O)cc(C(=O)O[C@H]3COC(=O)C[C@H](N)c4cc(O)c(c(Cl)c4)O[C@@H]4C#C/C=C/3C#CC3=CC=C[C@@]34O[C@@H]3OC(C)(C)[C@@H](N(C)C)[C@@H](O)[C@H]3O)c2NC1=O,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8078,ML00001169,CHEMBL3907376,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1cccc(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8079,ML00005292,,,CC[C@@H]1[C@@H](C)O[C@@](OC)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C=C/C=C/[C@H](C)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]3(OC)C[C@@H](O[C@H]4C[C@H](O)[C@H](O)[C@H](C)O4)[C@H](CC)[C@@H](C)O3)OC(=O)/C(C)=C/C=C/[C@@H]2C)C[C@H]1O[C@H]1C[C@H](O)[C@H](O)[C@H](C)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8080,ML00007320,,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)CNC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8081,ML00009198,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCNCCO)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009198_numbered.png,2026-03-19 06:58:28.035949
8082,ML00005983,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCNCCCN(C)C)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005983_numbered.png,2026-03-19 06:58:28.089529
8083,ML00010852,,,C=C1C[C@H]2CCC[C@H](OC)C[C@@H](c3coc(/C=C(\C)[C@@H](C)OC)n3)OC(=O)[C@@H](C)C[C@H](C)[C@@H](OP(=O)(O)O)C[C@@H](C1)O2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8084,ML00000396,CHEMBL3909009,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(S(=O)(=O)C3CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1cc(F)c2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8085,ML00005960,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)/C(C)=C/C)C(C)C)[C@@H](C)OC(=O)[C@H](CCc2ccc(O)cc2)NC(=O)[C@@H](CCC(=O)O)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8086,ML00006435,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN2C[C@@H](C)C[C@@H](C)C2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006435_numbered.png,2026-03-19 06:58:28.164907
8087,ML00006599,,,CC[C@@H]1C[C@H](C)C(=O)/C=C\C(C)=C/[C@H](C)[C@@H](CC)OC(=O)C[C@@H](O)[C@@H](C)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006599_numbered.png,2026-03-19 06:58:28.215399
8088,ML00009140,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(Br)C#Cc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8089,ML00007919,,,C[C@@]12CSC(=N1)c1csc(n1)CNC(=O)C[C@@H](/C=C/CCS)OC(=O)CNC2=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8090,ML00003675,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=N/O)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003675_numbered.png,2026-03-19 06:58:28.280210
8091,ML00010949,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)C=C[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010949_numbered.png,2026-03-19 06:58:28.331451
8092,ML00005873,,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC(=O)/C=C/C(=O)NC3=C(O)CCC3=O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00005873_numbered.png,2026-03-19 06:58:28.384405
8093,ML00000817,CHEMBL2324844,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](CCCN=[N+]=[N-])CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8094,ML00006618,,,CC[C@H]1C[C@@H](C)C(=O)/C=C\C(C)=C/[C@H](CO)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006618_numbered.png,2026-03-19 06:58:28.445397
8095,ML00009578,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(OC)C[C@@H](OC)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009578_numbered.png,2026-03-19 06:58:28.495849
8096,ML00011018,,,C/C(=C/c1csc(C)n1)[C@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H]2O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00011018_numbered.png,2026-03-19 06:58:28.547517
8097,ML00004376,,,CC[C@@H]1[C@@H](C)O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C=C/C=C/[C@H](C)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]3(O)C[C@@H](O[C@H]4C[C@H](O)[C@H](O)[C@H](C)O4)[C@H](CC)[C@@H](C)O3)OC(=O)/C=C/C=C/[C@@H]2C)C[C@H]1O[C@H]1C[C@H](O)[C@H](O)[C@H](C)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8098,ML00002989,,,COc1cc2c(c(C(=O)O[C@H]3COC(=O)C[C@H](N)c4cc(O)c(c(Cl)c4)O[C@H]4c5ccc3cc5C3=CC=C[C@]34O[C@@H]3OC(C)(C)[C@@H](N(C)C)[C@@H](O)[C@H]3O)c1)NC(=O)[C@H](C)O2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8099,ML00003685,,,CC[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](CO)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003685_numbered.png,2026-03-19 06:58:28.622634
8100,ML00007192,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@H](O)[C@@](C)(Cl)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,11.0,"[3, 5, 6, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007192_numbered.png,2026-03-19 06:58:28.682386
8101,ML00007694,,,C/C(=C\c1coc(C)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007694_numbered.png,2026-03-19 06:58:28.733769
8102,ML00009389,,,C/C=C/C=C\C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8103,ML00007522,,,Cc1cc(Cl)ccc1OCC(=O)ON=C1CCCCCCCCCCC(=O)OC(C)CC1,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/ML00007522_numbered.png,2026-03-19 06:58:28.771943
8104,ML00002536,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](OC(=O)/C=C/c3ccccc3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](OC(C)=O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002536_numbered.png,2026-03-19 06:58:28.823838
8105,ML00002836,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccc(COC(=O)CNC(=O)OC(C)(C)C)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8106,ML00006857,,,Cc1ccc(OCC(=O)ON=C2CCCCCCCCCCC(=O)OCCC2)cc1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006857_numbered.png,2026-03-19 06:58:28.855954
8107,ML00006778,,,CC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2cc(ccn2)C2=N[C@@](C)(CS2)C(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8108,ML00004415,,,CCC(=O)O[C@@H]1CC(=O)O[C@@H](C/C=C/c2cnc3ccccc3c2)CCCN(C)C[C@H](O)[C@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(OC(=O)CC)[C@@H](OC(=O)NCCO)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H]1OC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8109,ML00002664,,,CC[C@H]1OC(=O)C[C@@H](OC(C)=O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002664_numbered.png,2026-03-19 06:58:28.923650
8110,ML00003393,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003393_numbered.png,2026-03-19 06:58:28.976571
8111,ML00008827,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@@H](C)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8112,ML00009852,,,CO[C@H]1/C=C\C=C(\C)C[C@H](C)[C@H](O)[C@H](C)/C=C(C)\C=C(\C)C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](OC)[C@H](C)[C@@H](C(C)C)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009852_numbered.png,2026-03-19 06:58:29.031094
8113,ML00006889,,,COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OCCCCCC/C(S)=N/1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8114,ML00004379,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2cccc(N(C)C)c2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004379_numbered.png,2026-03-19 06:58:29.095853
8115,ML00000627,CHEMBL3628312,,CC(C)[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)NCc1ccc(Cl)cc1CC(=O)O2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8116,ML00003891,,,CCC(=O)O[C@@H]1/C=C\[C@@H]2O[C@@H]2C[C@H](C)OC(=O)C[C@@H](OC(C)=O)[C@H](OC)[C@H](O[C@@H]2O[C@@H](C)[C@@H](O[C@@H]3C[C@](C)(O)[C@H](O)[C@@H](C)O3)[C@H](N(C)C)[C@@H]2O)[C@@H](CC=O)C[C@@H]1C,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003891_numbered.png,2026-03-19 06:58:29.151864
8117,ML00009465,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCNCCCN(C)C)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009465_numbered.png,2026-03-19 06:58:29.205103
8118,ML00006547,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ncnc3ccccc23)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006547_numbered.png,2026-03-19 06:58:29.262128
8119,ML00004572,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=N/OCCOc2ccccc2)/C=C/C(C)=C/C1CO[C@@H]1C[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004572_numbered.png,2026-03-19 06:58:29.318893
8120,ML00000631,CHEMBL393361,,CC(C)[C@H]1NC(=O)[C@@H](C)NC(=O)[C@@H](C)NC(=O)C[C@@H](/C=C/CCS)OC(=O)CNC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8121,ML00003495,,,COC1C(OC(C)=O)CC(=O)OC(C)C/C=C\C=C/C(O)C(C)CC(CC=O)C1OC1OC(C)C(OC2CC(C)(O)C(OC(C)=O)C(C)O2)C(N(C)C)C1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003495_numbered.png,2026-03-19 06:58:29.370820
8122,ML00010585,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](CCO)C[C@H](C)C(=O)/C=C\[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010585_numbered.png,2026-03-19 06:58:29.422051
8123,ML00003395,,,CO[C@H]1[C@@H](OC[C@H]2OC(=O)C[C@@H](O)[C@H](C)[C@@H](CO[C@@H]3C[C@@H](N(C)C)[C@H](O)[C@@H](C)O3)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\[C@]3(C)O[C@@H]3[C@@H]2C)O[C@@H](C)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003395_numbered.png,2026-03-19 06:58:29.473792
8124,ML00001996,CHEMBL4091328,,C=C1[C@H](OO)CCC(=O)O[C@H](/C(C)=C/C=C/C[C@]2(O)CC(=O)O[C@@H](CC)[C@@H]2C)[C@@H](C)/C=C\C=C/[C@H](OC(N)=O)[C@@H](C)[C@@H](O)[C@@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 11, 12, 13, 14]",ring_size_16/standard/numbered/ML00001996_numbered.png,2026-03-19 06:58:29.521587
8125,ML00001358,CHEMBL87490,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](COCc2ccccc2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H]2O[C@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8126,ML00003494,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@H]3C[C@](C)(O)[C@H](OC(C)=O)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@@H](CC=O)C[C@H](C)[C@@H](O)/C=C\C=C/C[C@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003494_numbered.png,2026-03-19 06:58:29.574984
8127,ML00005523,,,C[C@@H]1OC(=O)[C@@H](c2cc(O)cc(O)c2)NC(=O)[C@H](c2cc(O)cc(O)c2)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]1NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Cl)[nH]1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8128,ML00004519,,,CC[C@@H]1[C@@H](C)O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(C)=C/C=C/[C@H](C)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]3(O)C[C@@H](O[C@H]4C[C@H](O)[C@H](O)[C@H](C)O4)[C@H](CC)[C@@H](C)O3)OC(=O)/C(C)=C/C=C/[C@@H]2C)C[C@H]1O[C@H]1C[C@H](O)[C@H](O)[C@H](C)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8129,ML00004849,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)OCCC(/C=C/Cc4cnc5ccccc5c4)CN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8130,ML00000180,CHEMBL196415,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@]2(CF)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00000180_numbered.png,2026-03-19 06:58:29.648333
8131,ML00008780,,,C=CCON=C1CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00008780_numbered.png,2026-03-19 06:58:29.671214
8132,ML00009537,,,CC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](C)C[C@@H](C)[C@@H](O)/C=C\C=C/[C@@H]1CO[C@H]1O[C@@H](C)[C@H](O)[C@@H](OC)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009537_numbered.png,2026-03-19 06:58:29.718762
8133,ML00005814,,,CCCCC[C@@H]1OCO[C@@]2(C)/C=C(C)\C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]3(O)C[C@@H](O[C@H]4C[C@@H](O)[C@H](O)[C@@H](C)O4)[C@H](C)[C@@H](C)O3)[C@@H](OC)/C=C\C=C(\C)C[C@H]1[C@@H]2O,standard_macrolactone,16.0,,,success,,6.0,"[3, 4, 8, 11, 12, 14]",ring_size_16/standard/numbered/ML00005814_numbered.png,2026-03-19 06:58:29.764342
8134,ML00004861,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2cc(Cl)cc(Cl)c2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004861_numbered.png,2026-03-19 06:58:29.825403
8135,ML00004169,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(C)CCCN(C)C(=O)[C@H](C)N)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004169_numbered.png,2026-03-19 06:58:29.879093
8136,ML00007267,,,CC1=C2Cc3cc(ccc3O)C(=O)O[C@H](C(C)(C)O)CC[C@]3(C)O[C@H]3C/C=C(/C)[C@H]2CC1,standard_macrolactone,16.0,,,success,,3.0,"[3, 6, 10]",ring_size_16/standard/numbered/ML00007267_numbered.png,2026-03-19 06:58:29.910252
8137,ML00011020,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H](C)[C@@H](C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8138,ML00000030,CHEMBL1796689,LARGAZOLE THIOL,CC(C)[C@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCS)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8139,ML00005927,,,CO/C1=C/C(C)=C\[C@@H](C)[C@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@@]2(OC)C[C@@H](OC(=O)/C=C/C(=O)NC3=C(O)CCC3=O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00005927_numbered.png,2026-03-19 06:58:29.970033
8140,ML00009593,,,CO/C1=C/C(C)=C\[C@@H](C)[C@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC(C)=O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009593_numbered.png,2026-03-19 06:58:30.017718
8141,ML00001347,CHEMBL3244596,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](OC(C)=O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001347_numbered.png,2026-03-19 06:58:30.065534
8142,ML00010633,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](CCCc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8143,ML00010107,,,CC(C)C[C@@H]1NC(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8144,ML00002303,,,CCCC(=O)O[C@@H]1[C@@H](C)O[C@@H](O[C@H]2[C@H](C)O[C@H](O[C@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C/C=C\C=C/C(=O)[C@H](C)C[C@@H]3CC=O)[C@@H](O)[C@@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002303_numbered.png,2026-03-19 06:58:30.127508
8145,ML00005888,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005888_numbered.png,2026-03-19 06:58:30.187352
8146,ML00006518,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCNc2ccc(OC(C)=O)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006518_numbered.png,2026-03-19 06:58:30.246221
8147,ML00004624,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCCc4cnc5ccccc5c4)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004624_numbered.png,2026-03-19 06:58:30.304396
8148,ML00010947,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@H](CC=O)C[C@H](C)C(=O)/C=C\[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010947_numbered.png,2026-03-19 06:58:30.356432
8149,ML00001551,CHEMBL3650147,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(=O)N3CCOCC3)[C@H]2O)[C@](C)(OC)CCC[C@@H](C)C(=O)[C@H](C)C2N(CCCN(Cc3c(Cl)cncc3Cl)c3ccc(OC)c(OC4CCCC4)c3)C(=O)O[C@@]21C,standard_macrolactone,16.0,,,success,,11.0,"[3, 4, 6, 7, 8, 12, 12, 13, 14, 15, 16]",ring_size_16/standard/numbered/ML00001551_numbered.png,2026-03-19 06:58:30.417343
8150,ML00008498,,,CC(=O)C[C@@H]1CCC(=O)/C=C\C(=O)O[C@H](CC(C)=O)CCC(=O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8151,ML00009065,,,CC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](C)C[C@@H](C)C(=O)/C=C\C=C/[C@@H]1CO[C@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009065_numbered.png,2026-03-19 06:58:30.469708
8152,ML00001593,CHEMBL3251872,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](N(C)C)[C@@H](OC(C)=O)[C@H](O[C@@H]3[C@@H](OC)[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)O[C@@H]2C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001593_numbered.png,2026-03-19 06:58:30.518124
8153,ML00000809,CHEMBL2324848,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@@H](CCCn3cc(C(C)(C)O)nn3)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8154,ML00006878,,,O=C1CCCCCCCCCCC(NS(=O)(=O)c2cc(Cl)ccc2Cl)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006878_numbered.png,2026-03-19 06:58:30.549034
8155,ML00007208,,,CO/C1=C\C(C)=C\[C@@H](C)C(=O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)C(=O)O)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00007208_numbered.png,2026-03-19 06:58:30.594536
8156,ML00002921,,,COC1C(O)CC(=O)OC(C)C/C=C/C=C/[C@H](O[C@H]2CC[C@H](N(C)C)[C@H](C)O2)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@@H]2C[C@](C)(O)[C@H](O)[C@@H](C)O2)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002921_numbered.png,2026-03-19 06:58:30.642562
8157,ML00000202,CHEMBL1515216,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)C(C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00000202_numbered.png,2026-03-19 06:58:30.689179
8158,ML00009057,,,CC[C@H]1OC(=O)C[C@@H](OC(C)=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@H](N(C)C)[C@H]2OC(C)=O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009057_numbered.png,2026-03-19 06:58:30.741486
8159,ML00003779,,,CCC(=O)O[C@H]1CC(=O)O[C@@H](C)C/C=C\C=C/[C@@H](O)[C@@H](C)C[C@H](CC=O)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003779_numbered.png,2026-03-19 06:58:30.788656
8160,ML00004596,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCCCCc4ccccc4)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004596_numbered.png,2026-03-19 06:58:30.843804
8161,ML00008807,,,CC(=O)O[C@H]1CCCCCCCCC[C@@H](C)OC(=O)/C=C/C1=O,standard_macrolactone,16.0,,,success,,3.0,"[3, 13, 14]",ring_size_16/standard/numbered/ML00008807_numbered.png,2026-03-19 06:58:30.873336
8162,ML00006709,,,O=C1CCCCCCCCCC/C(=N\OC(=O)COc2ccc(Cl)cc2)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006709_numbered.png,2026-03-19 06:58:30.896348
8163,ML00006951,,,CCCCCC1/C=C/C=C\CCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,1.0,[3],ring_size_16/standard/numbered/ML00006951_numbered.png,2026-03-19 06:58:30.918265
8164,ML00002386,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOC(C(F)(F)F)C(F)(F)F)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002386_numbered.png,2026-03-19 06:58:30.972045
8165,ML00005698,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)/C(C)=C/C)C(C)C)[C@@H](C)OC(=O)[C@H](CCCc2ccc(O)cc2)NC(=O)[C@@H](CCC(=O)O)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8166,ML00003492,,,CO[C@H]1[C@@H](OC(C)=O)CC(=O)O[C@H](C)C[C@@H]2O[C@@H]2/C=C\[C@H](O)[C@@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@@H](C)[C@@H](O[C@@H]2C[C@](C)(O)[C@H](OC(C)=O)[C@H](C)O2)[C@@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003492_numbered.png,2026-03-19 06:58:31.029853
8167,ML00002071,CHEMBL4097785,,CCc1cc2ccc1CCOC(=O)Nc1cccc(c1)CNC(=O)C2Nc1cccc(C(N)=O)c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8168,ML00002661,,,CCC(=O)O[C@H]1CC(=O)O[C@H](C)C[C@@H]2O[C@@H]2/C=C\[C@H](OC(=O)CC)[C@@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](O)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002661_numbered.png,2026-03-19 06:58:31.084814
8169,ML00001625,CHEMBL3244606,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](N(C)C)[C@@H](OC(=O)CCC(=O)O)[C@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(=O)CCC(=O)O)[C@H](C)C[C@@H]3CC=O)O[C@@H]2C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001625_numbered.png,2026-03-19 06:58:31.132039
8170,ML00000090,CHEMBL1836143,,C/C=C1/NC(=O)[C@@H](CS)NC(=O)[C@@H](C(C)C)NC(=O)C[C@@H](/C=C/CCS)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8171,ML00003561,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=N\OCc2ccccc2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003561_numbered.png,2026-03-19 06:58:31.199162
8172,ML00000152,CHEMBL3310505,,C/C=C1\NC(=O)[C@H]2CSSCC/C=C/[C@@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8173,ML00005098,,,C/C=C(\NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCN1C(=O)/C(=C/C)NC(=O)CC(O)CCCCC)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@H](CCN)C(=O)N[C@@H](CCCCN)C(=O)O[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8174,ML00004563,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCCc4cccc5ccccc45)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004563_numbered.png,2026-03-19 06:58:31.280698
8175,ML00009871,,,CO[C@@H]1C[C@H](OC(N)=O)[C@@H]2C=C[C@@H]3/C=C(C)/C=C/[C@@H](C)[C@H](/C(C)=C/[C@@H](C)NC(C)=O)OC(=O)/C=C/C=C(C)\C=C\[C@]3(C)[C@@H]2C1,standard_macrolactone,16.0,,,success,,5.0,"[3, 4, 7, 10, 13]",ring_size_16/standard/numbered/ML00009871_numbered.png,2026-03-19 06:58:31.317023
8176,ML00002112,CHEMBL3742171,,CC(C)[C@@H]1NC(=O)C[C@H](/C=C/c2ccccc2)OC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8177,ML00005474,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H](CC=O)C[C@@H](C)[C@@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)/C=C\C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005474_numbered.png,2026-03-19 06:58:31.372236
8178,ML00002725,,,CCOC(=O)/C=C/C[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](COC2OC(C)C(O)C(OC)C2OC)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1OC1OC(C)C(O)C(N(C)C)C1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002725_numbered.png,2026-03-19 06:58:31.425787
8179,ML00003922,,,CO[C@H]1[C@@H](O)CC(=O)O[C@@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@H](CC=O)[C@H]1O[C@@H]1O[C@@H](C)[C@H](O[C@@H]2C[C@](C)(O)[C@@H](OC(=O)CC(C)C)[C@@H](C)O2)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003922_numbered.png,2026-03-19 06:58:31.472039
8180,ML00006410,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O[C@@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@H](C)C[C@@H](CC=O)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006410_numbered.png,2026-03-19 06:58:31.523175
8181,ML00007159,,,C/C1=C/C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)/C(C)=C\CC1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007159_numbered.png,2026-03-19 06:58:31.574086
8182,ML00001302,CHEMBL3251852,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001302_numbered.png,2026-03-19 06:58:31.621973
8183,ML00008889,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCNCC(O)CO)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00008889_numbered.png,2026-03-19 06:58:31.673186
8184,ML00006811,,,CC1CCC(=NOC(=O)COc2ccc(Cl)cc2Cl)CCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/ML00006811_numbered.png,2026-03-19 06:58:31.700012
8185,ML00004281,,,CCC(=O)OC1C(C)OC(OC2C(C)OC(OC3C(CC=O)CC(C)C(=O)/C=C\C4OC4CC(C)OC(=O)CC(OC(C)=O)C3OC)C(O)C2N(C)C)CC1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004281_numbered.png,2026-03-19 06:58:31.745439
8186,ML00009625,,,COC1C(O)CC(=O)OC(C)C/C=C\C=C/C(O)C(C)CC(CC=O)C1OC1OC(C)C(OC2CC(C)(O)C(OC(C)=O)C(C)O2)C(N(C)C)C1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009625_numbered.png,2026-03-19 06:58:31.790444
8187,ML00002542,,,CCN(CC)Cc1ccc([C@H](Cl)[C@H](O)[C@@H](C)[C@@H]2C/C=C/C(=O)N[C@H](Cc3ccc(OC)c(Cl)c3)C(=O)NCC(C)(C)C(=O)O[C@@H](CC(C)C)C(=O)O2)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8188,ML00000820,CHEMBL3897709,,CCN(Cc1nccs1)C(=O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1ccc3c(N)nccc3c1)c1ccc(c(C)c1)[C@@H](C)COC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8189,ML00005650,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOS(=O)(=O)c2ccc(C)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005650_numbered.png,2026-03-19 06:58:31.858307
8190,ML00004709,,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](C)[C@H](O)CC(=O)O[C@H](CC)[C@@H](CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC)/C=C(C)\C=C/C(=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004709_numbered.png,2026-03-19 06:58:31.917368
8191,ML00008015,,,O=C1CCCCCCCCCCCCCCO1,standard_macrolactone,16.0,,,success,,0.0,[],ring_size_16/standard/numbered/ML00008015_numbered.png,2026-03-19 06:58:31.938731
8192,ML00003385,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC(=O)/C=C/C(=O)O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00003385_numbered.png,2026-03-19 06:58:31.993480
8193,ML00003568,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC(=O)Nc1ccc(OC)cc1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003568_numbered.png,2026-03-19 06:58:32.054537
8194,ML00009070,,,CO/C1=C\C(C)=C\[C@@H](C)C(=O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009070_numbered.png,2026-03-19 06:58:32.104322
8195,ML00002916,,,CO[C@H]1[C@H](O)CC(=O)O[C@H](C)C/C=C\C=C/[C@@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@H](C)C[C@@H](CC=O)[C@H]1O[C@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002916_numbered.png,2026-03-19 06:58:32.152511
8196,ML00010586,,,CC[C@H]1OC(=O)C[C@@H](O)[C@@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C\[C@@]2(C)O[C@H]2[C@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010586_numbered.png,2026-03-19 06:58:32.206965
8197,ML00000085,CHEMBL4099942,,CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCC(=O)NO)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8198,ML00000666,CHEMBL3317812,,C[C@@]12CSC(=N1)c1csc(n1)CNC(=O)C[C@@H](/C=C/CCS)OC(=O)[C@H](Cc1c[nH]cn1)NC2=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8199,ML00008241,,,C[C@H]1C/C=C\C(=O)O[C@H](C)CC(=O)O[C@@H](C)[C@H](O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8200,ML00007665,,,CC(=Cc1csc(C)n1)[C@@H]1C[C@H]2O[C@@H]2CCC[C@H](C)[C@@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007665_numbered.png,2026-03-19 06:58:32.278850
8201,ML00010936,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/C(=O)[C@@H](C)C[C@@H](CC)[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O)[C@H](C)O2)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010936_numbered.png,2026-03-19 06:58:32.328724
8202,ML00005489,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O[C@@H]2CC[C@H](N(C)C)[C@@H](C)O2)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005489_numbered.png,2026-03-19 06:58:32.379942
8203,ML00005764,,,CCC(=O)O[C@H]1CC(=O)O[C@H](C)C[C@@H]2O[C@@H]2/C=C\[C@H](OC(=O)CC)[C@@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@H](C)[C@@H](O[C@@H]3C[C@](C)(O)[C@H](OC(=O)CC)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005764_numbered.png,2026-03-19 06:58:32.436215
8204,ML00010932,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010932_numbered.png,2026-03-19 06:58:32.495587
8205,ML00001100,CHEMBL3902759,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(C3(c4nnn[nH]4)CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8206,ML00006851,,,CC=C1NC(=O)C2CSSCCC=CC(CC(=O)NC(C(C)C)C(=O)N2)OC(=O)C(C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8207,ML00005815,,,CCCCC[C@@H]1OCO[C@@]2(C)/C=C(C)\C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]3(O)C[C@@H](O[C@H]4C[C@@H](O)[C@H](O)[C@@H](C)O4)[C@H](C)[C@@H](C)O3)[C@@H](OC)/C=C\C=C(\C)C[C@@H]1[C@@H]2O,standard_macrolactone,16.0,,,success,,6.0,"[3, 4, 8, 11, 12, 14]",ring_size_16/standard/numbered/ML00005815_numbered.png,2026-03-19 06:58:32.556304
8208,ML00010898,,,CC(=O)O[C@@H](C)[C@@]12/C=C\C=C/C(=O)O[C@@H]3C[C@H]4O[C@@H]5C=C(C)CC[C@]5(COC(=O)C=C(CCO1)[C@H]2O)[C@]3(C)[C@]41CO1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8209,ML00009366,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8210,ML00003255,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN2C(=O)c3ccccc3C2=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003255_numbered.png,2026-03-19 06:58:32.624505
8211,ML00001036,CHEMBL601144,,CC1=CC[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00001036_numbered.png,2026-03-19 06:58:32.674331
8212,ML00001515,CHEMBL256131,POLYDISCAMIDE D,CC(C)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(Br)cc1)NC(=O)[C@@H](C)NC=O)C(=O)N[C@H](C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CS(=O)(=O)O)C(=O)N[C@@H]1C(=O)N(C)[C@@H](CCC(N)=O)C(=O)N[C@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](CC(=O)O)C(=O)O[C@@H]1C)C(C)(C)C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8213,ML00002569,,,CO[C@H]1[C@@H](O)CC(=O)O[C@@H](C)C/C=C\C=C/[C@H](O[C@H]2C[C@](C)(O)[C@H](O)CO2)[C@H](C)C[C@H](CC=O)[C@H]1O[C@H]1O[C@H](C)[C@@H](O[C@@H]2C[C@](C)(O)[C@H](O)[C@@H](C)O2)[C@@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002569_numbered.png,2026-03-19 06:58:32.754198
8214,ML00010908,,,CCC(=O)O[C@H]1CC(=O)O[C@H](C)C/C=C\C=C/C(=O)[C@@H](C)C[C@@H](CC)[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@@H](N(C)C)[C@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010908_numbered.png,2026-03-19 06:58:32.818504
8215,ML00009541,,,CCC[C@@H]1OC(=O)[C@H](C)[C@H]2CC[C@H](O2)[C@@H](C)[C@H]([C@H](CC)[C@H]2CC[C@@H](C[C@@H](CCC)N(C)C)O2)OC(=O)[C@@H](C)[C@H]2CC[C@H](O2)[C@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8216,ML00009383,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC(=O)Nc1ccc(Cl)cc1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009383_numbered.png,2026-03-19 06:58:32.902939
8217,ML00009322,,,CC(C)C[C@@H]1OC(=O)[C@H](C)CNC(=O)[C@@H](Cc2ccc(O)c(Cl)c2)NC(=O)/C=C\C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8218,ML00002669,,,CCC(=O)O[C@H]1CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H](O[C@H]2O[C@H](C)[C@@H](O[C@@H]3C[C@@](C)(O)[C@@H](OC(=O)CC)[C@@H](C)O3)[C@H](N(C)C)[C@@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002669_numbered.png,2026-03-19 06:58:32.984788
8219,ML00010952,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010952_numbered.png,2026-03-19 06:58:33.053666
8220,ML00006434,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN2C[C@@H](C)C[C@@H](C)C2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006434_numbered.png,2026-03-19 06:58:33.119068
8221,ML00002491,,,CCC/C=C/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H]1C(=O)N2CCC[C@H]2C(=O)N2CCCC[C@H]2C(=O)N[C@@H](C)C(=O)N2C[C@H](C)C[C@H]2C(=O)O[C@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8222,ML00000833,CHEMBL263425,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8223,ML00007496,,,C/C(=C\c1csc(C)n1)[C@@H]1C/C=C\CCC[C@H](C)[C@H](O)CC(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,7.0,"[3, 10, 11, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007496_numbered.png,2026-03-19 06:58:33.189537
8224,ML00007100,,,O=C1CCCCCCCCCCC(NS(=O)(=O)c2ccccc2)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00007100_numbered.png,2026-03-19 06:58:33.217273
8225,ML00000080,CHEMBL1356463,,CO[C@H]1COC(=O)C/C=C\[C@H](C)[C@@H](NS(=O)(=O)c2ccc(C)cc2)COC(=O)CCC[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8226,ML00006438,,,CC[C@H]1OC(=O)C[C@@H](O)[C@@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](O)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@H](CCO)C[C@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO[C@H]1O[C@@H](C)[C@H](O)[C@@H](OC)[C@@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006438_numbered.png,2026-03-19 06:58:33.296737
8227,ML00010939,,,CCC1OC(=O)CC(O)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(CC=O)CC(C)C(=O)C=CC2(C)OC2C1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010939_numbered.png,2026-03-19 06:58:33.360911
8228,ML00002741,,,CCC(=O)O[C@@H]1CC(=O)O[C@@H](C)C/C=C\C=C/[C@H](O)[C@@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3C[C@@](C)(O)[C@H](OC(=O)CC(C)C)[C@H](C)O3)[C@@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002741_numbered.png,2026-03-19 06:58:33.415071
8229,ML00003499,,,CC[C@H]1OC(=O)CC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H](O)[C@@H](N(C)C)[C@H]2O)[C@H]2C[C@@H](O)[C@](C)(C2)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@@H](C)[C@@H](O)[C@@H](OC)[C@@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 6, 9, 10, 13, 14, 15]",ring_size_16/standard/numbered/ML00003499_numbered.png,2026-03-19 06:58:33.469239
8230,ML00009299,,,C/C(=C\c1csc(C)n1)[C@@H]1C/C=C\CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@](C)(CCOC(=O)c2cccc(N=[N+]=[N-])c2)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00009299_numbered.png,2026-03-19 06:58:33.517656
8231,ML00006058,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCSc2nnnn2C)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006058_numbered.png,2026-03-19 06:58:33.576473
8232,ML00009384,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC(=O)Nc1ccc(F)cc1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009384_numbered.png,2026-03-19 06:58:33.629089
8233,ML00009199,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(C)C)C[C@@H](C)C(=O)/C=C/[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009199_numbered.png,2026-03-19 06:58:33.680603
8234,ML00005633,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCN2C(=O)c3ccccc3C2=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005633_numbered.png,2026-03-19 06:58:33.736132
8235,ML00010441,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@]56OCC/C(=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)[C@H]5O[C@@H](O)[C@@H]6O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8236,ML00001412,CHEMBL423091,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@@H]3CCCCC3NC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8237,ML00004390,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCCCc4ccccc4)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004390_numbered.png,2026-03-19 06:58:33.805277
8238,ML00009626,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@H](O)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](C(C)=O)C[C@@H](C)[C@@H](O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009626_numbered.png,2026-03-19 06:58:33.851495
8239,ML00001188,CHEMBL3901206,,COc1cc2c(F)cc1[C@@H](C)COC(=O)Nc1ccc(S(=O)(=O)C3CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1cc2ccnc(N)c2cc1F,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8240,ML00000116,CHEMBL2436595,,CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2coc(n2)CNC(=O)C[C@@H](/C=C/CCS)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8241,ML00009804,,,CO[C@H]1[C@H](OC[C@H]2/C=C\C=C/C(=O)[C@H](C)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@](O)([C@H](C)O)[C@H]3O)[C@@H](C)/C=C\C(=O)O[C@@H]2C)O[C@H](C)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009804_numbered.png,2026-03-19 06:58:33.916298
8242,ML00002296,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002296_numbered.png,2026-03-19 06:58:33.970403
8243,ML00010851,,,C=C1C[C@H]2C[C@H](O)C[C@H](OC)C[C@@H](c3coc(/C=C(\C)[C@@H](C)OC)n3)OC(=O)[C@@H](C)C[C@H](C)[C@@H](OP(=O)(O)O)C[C@@H](C1)O2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8244,ML00008826,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)C3OC3c3ccccc3)OC(=O)[C@H](CC(C)C)CC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8245,ML00001192,CHEMBL3961226,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1cc(F)c(S(=O)(=O)C3CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1cc2ccnc(N)c2cc1F,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8246,ML00000161,CHEMBL3622729,,C/C=C1\NC(=O)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCS)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8247,ML00003900,,,CCC(=O)O[C@H]1CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H](O[C@H]2O[C@H](C)[C@H](O[C@@H]3C[C@@](C)(O)[C@@H](OC(C)=O)[C@@H](C)O3)[C@@H](N(C)C)[C@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003900_numbered.png,2026-03-19 06:58:34.052845
8248,ML00006371,,,CCCC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H]1C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@H](C)CC)C(=O)O[C@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8249,ML00008846,,,COc1ccc(C[C@H]2NC(=O)/C=C\C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8250,ML00002384,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCCc2ccncc2)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002384_numbered.png,2026-03-19 06:58:34.132199
8251,ML00009471,,,CCC[C@H]1C[C@@H]2CC[C@@H](O2)[C@H](C)C(=O)O[C@@H]([C@H](CC)[C@H]2CC[C@@H](C[C@@H](CCC)N(C)C)O2)[C@H](C)[C@@H]2CC[C@@H](O2)[C@@H](C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8252,ML00010935,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010935_numbered.png,2026-03-19 06:58:34.196217
8253,ML00003570,,,CO/C1=C/C(C)=C\[C@@H](C)[C@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@]2(OC)C[C@@H](OC(=O)/C=C/C(=O)O)[C@H](C)[C@@H](C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00003570_numbered.png,2026-03-19 06:58:34.248191
8254,ML00010165,,,CC[C@H]1C[C@@H](C)C(=O)/C=C\C(C)=C/[C@H](C)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010165_numbered.png,2026-03-19 06:58:34.304069
8255,ML00003401,,,CCCC(=O)OC1C(C)OC(OC2C(C)OC(O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)C(O)C2N(C)C)CC1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003401_numbered.png,2026-03-19 06:58:34.356503
8256,ML00009563,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(C)CCCN(C)C)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009563_numbered.png,2026-03-19 06:58:34.418654
8257,ML00007263,,,CC1=C2Cc3cc(ccc3O)C(=O)OC(C)(C)[C@H](Br)CC[C@](C)(O)[C@H](Br)CC[C@]2(C)[C@@H](Br)CC1,standard_macrolactone,16.0,,,success,,7.0,"[3, 3, 4, 7, 7, 8, 11]",ring_size_16/standard/numbered/ML00007263_numbered.png,2026-03-19 06:58:34.472815
8258,ML00006920,,,O=C1CCCCCCCCCCC(NS(=O)(=O)c2cccc([N+](=O)[O-])c2)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006920_numbered.png,2026-03-19 06:58:34.502627
8259,ML00008888,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(C)CCO)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00008888_numbered.png,2026-03-19 06:58:34.571218
8260,ML00009272,,,CC[C@H](O)[C@@H](C)/C=C/C(=O)[C@H](C)[C@H](O)[C@H](C)[C@@H]1OC(=O)/C(C)=C\C(C)=C/[C@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009272_numbered.png,2026-03-19 06:58:34.630127
8261,ML00009365,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c3ccccc3)OC(=O)[C@@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8262,ML00007778,,,CO[C@H]1CCCCCCCCC[C@@H](C)OC(=O)/C=C/C1=O,standard_macrolactone,16.0,,,success,,3.0,"[3, 13, 14]",ring_size_16/standard/numbered/ML00007778_numbered.png,2026-03-19 06:58:34.679591
8263,ML00010017,,,C[C@H]1CCC[C@@]2(C)O[C@H]2C[C@@H](c2ccc3cccnc3c2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00010017_numbered.png,2026-03-19 06:58:34.745111
8264,ML00004405,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCCc4ccccc4)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(C)=O,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004405_numbered.png,2026-03-19 06:58:34.819089
8265,ML00000839,CHEMBL2324842,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](CCN=[N+]=[N-])CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8266,ML00005618,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCCc2ccnc3ccccc23)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005618_numbered.png,2026-03-19 06:58:34.899613
8267,ML00007055,,,CC1CCC(NS(=O)(=O)c2ccc(Cl)cc2)CCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/ML00007055_numbered.png,2026-03-19 06:58:34.933490
8268,ML00004518,,,CC[C@@H]1[C@@H](C)O[C@@](OC)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C=C/C=C/[C@H](C)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]3(OC)C[C@@H](O[C@H]4C[C@H](O)[C@H](O)[C@H](C)O4)[C@H](CC)[C@@H](C)O3)OC(=O)/C=C/C=C/[C@@H]2C)C[C@H]1O[C@H]1C[C@H](O)[C@H](O)[C@H](C)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8269,ML00010612,,,CCCCCCCCCCCCCCCCON=C1CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00010612_numbered.png,2026-03-19 06:58:34.965869
8270,ML00004862,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](C/C=C/c4cnc5ccccc5c4)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8271,ML00005373,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@@H](CCCn3cc(C[C@@H]4NC(=O)[C@@H](Cc5ccccc5)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC4=O)nn3)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8272,ML00000816,CHEMBL2324845,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@@H](CCCN=[N+]=[N-])CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8273,ML00010140,,,O=C1C[C@H](c2ccc(O)cc2)c2c(O)cc(O)c3c(=O)c(O)c(oc23)-c2cc(O)c(O)c(c2)O[C@@H]2O[C@@H](CO1)[C@@H](O)[C@H](O)[C@@H]2O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8274,ML00009821,,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](CCc2ccccc2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H]2O[C@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8275,ML00002659,,,CCC(=O)OC1CC(=O)OC(C)CC2OC2/C=C\C(O)C(C)CC(CC=O)C(OC2OC(C)C(OC3CC(C)(O)C(OC(=O)CC)C(C)O3)C(N(C)C)C2O)C1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002659_numbered.png,2026-03-19 06:58:35.055628
8276,ML00006846,,,C/C=C1\NC(=O)[C@H]2CSSCC/C=C\[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)C(C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8277,ML00007508,,,C/C(=C\c1csc(C)n1)[C@@H]1C/C=C\CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,7.0,"[3, 10, 11, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00007508_numbered.png,2026-03-19 06:58:35.105575
8278,ML00009387,,,C/C=C\C=C/C=C\C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8279,ML00000583,CHEMBL3410861,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](c3c(F)c(F)c(F)c(F)c3F)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8280,ML00009004,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(CCO)CCO)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009004_numbered.png,2026-03-19 06:58:35.172018
8281,ML00008989,,,COC1/C=C(\C)C[C@@H](C)[C@@H](O)[C@@H](C)CC(C)/C=C/CC(OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00008989_numbered.png,2026-03-19 06:58:35.219011
8282,ML00002998,,,C=C1Oc2cc(OC)cc(C(=O)O[C@H]3COC(=O)C[C@H](N)c4ccc(c(Cl)c4)O[C@@H]4C#C/C=C/3C#CC3=CC=C[C@@]34O[C@@H]3OC(C)(C)[C@@H](N(C)C)[C@@H](O)[C@H]3O)c2NC1=O,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8283,ML00009840,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CCCCC2)C[C@@H](C)C(=O)/C=C/[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009840_numbered.png,2026-03-19 06:58:35.278003
8284,ML00006859,,,CC(Oc1ccccc1)C(=O)ON=C1CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006859_numbered.png,2026-03-19 06:58:35.300900
8285,ML00000248,CHEMBL298167,,CNC(=O)[C@@H]1CCC(=O)OCCNC(=O)CC[C@H](C(=O)O)N[C@@H](CCc2ccccc2)C(=O)N1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8286,ML00000811,CHEMBL2324840,,C=CCOCCC[C@@H]1CNC(=O)[C@@H](Cc2ccc(OC)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8287,ML00002087,CHEMBL4080298,,CCc1cc2ccc1CCOC(=O)Nc1ccc(SC(C)C)c(c1)CN(C)C(=O)[C@@H]2Nc1cccc(C(N)=O)c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8288,ML00010789,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010789_numbered.png,2026-03-19 06:58:35.367711
8289,ML00001149,CHEMBL3949417,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(S(=O)(=O)C(C)(C)C)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8290,ML00010553,,,CC[C@H]1C[C@@H](C)C(=O)/C=C\C(C)=C/[C@H](C)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@H]1O[C@@H](C)C[C@@H](N(C)C)[C@@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010553_numbered.png,2026-03-19 06:58:35.423682
8291,ML00006802,,,CC(Oc1ccccc1Cl)C(=O)ON=C1CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006802_numbered.png,2026-03-19 06:58:35.446625
8292,ML00009635,,,CC[C@@H]1OC(=O)/C=C\[C@H](C)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@H](C)C[C@@H](C)C(=O)/C=C\[C@H]2O[C@@H]2[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009635_numbered.png,2026-03-19 06:58:35.491236
8293,ML00000060,CHEMBL1316258,,CO[C@H]1COC(=O)C/C=C\[C@H](C)[C@@H](NS(=O)(=O)c2ccc(C)cc2)COC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8294,ML00005990,,,CO[C@@H]1[C@@H](O[C@H]2C[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@@H](C)O3)[C@H](N(C)C)[C@@H]2O)[C@@H](CC=O)C[C@H](C)[C@@H](O[C@@H]2C[C@@H](N(C)C)C[C@@H](C)O2)/C=C\C=C/C[C@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005990_numbered.png,2026-03-19 06:58:35.543243
8295,ML00009864,,,CO[C@H]1/C=C\C(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](OC(=O)Nc2ccc(C(F)(F)F)cc2)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,6.0,"[3, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009864_numbered.png,2026-03-19 06:58:35.585141
8296,ML00006398,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](OC(=O)C(C)C)[C@@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@]2(O)C[C@@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3OC)[C@@H](C)[C@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00006398_numbered.png,2026-03-19 06:58:35.640429
8297,ML00002320,,,CC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@H](N(C)C)[C@H]2O)[C@H](C)C[C@@H](C)C(=O)C[C@@H](SC[C@@H](NC(C)=O)C(=O)O)[C@H]2O[C@@H]2[C@@H]1CO[C@H]1O[C@H](C)[C@H](O)[C@@H](OC)[C@@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 7, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00002320_numbered.png,2026-03-19 06:58:35.701312
8298,ML00001328,CHEMBL100603,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c3ccc(CO)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8299,ML00008181,,,C[C@@H]1CCCCCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,1.0,[3],ring_size_16/standard/numbered/ML00008181_numbered.png,2026-03-19 06:58:35.735166
8300,ML00004911,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=N\OCCCCc2ccc3ccccc3c2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004911_numbered.png,2026-03-19 06:58:35.794029
8301,ML00009608,,,COC(=O)[C@@H]1C[C@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C/C(C)=C/[C@@H](C)C(=O)[C@@H](C)C/C(C)=C/C=C/[C@@H]2OC)O[C@H](C(C)C)[C@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009608_numbered.png,2026-03-19 06:58:35.847953
8302,ML00004868,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc(C(=O)c3ccccc3)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004868_numbered.png,2026-03-19 06:58:35.904026
8303,ML00010471,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\CC[C@]56OCC/C(=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)[C@H]5O[C@@H](O)[C@@H]6O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8304,ML00003383,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@@]2(O)C[C@H](OC(=O)/C=C/C(=O)O)[C@@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00003383_numbered.png,2026-03-19 06:58:35.958307
8305,ML00001923,CHEMBL251309,,C[C@@]1(N)Cc2cc(F)cc(c2)CC[C@H](c2ccc(F)cc2)NC(=O)c2cc(cc(-c3ccccc3C#N)c2)COC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8306,ML00009529,,,CO[C@@H]1[C@@H](O[C@@H]2C[C@@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@H](C)[C@@H](O[C@H]2C[C@@H](N(C)C)C[C@@H](C)O2)/C=C\C=C/C[C@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009529_numbered.png,2026-03-19 06:58:36.010605
8307,ML00001340,CHEMBL294511,,O=C(NC(Cc1ccccc1)C(O)CN1CCCCCCCCCCCCC(c2ccccc2)OC1=O)O[C@H]1CO[C@H]2OCC[C@@H]12,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8308,ML00008138,,,CC1CCC(O)/C=C/C(=O)OC(C)CCC(O)/C=C/C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8309,ML00008982,,,CO/C1=C\C(C)=C\C(C)C(O)C(C)C/C(C)=C/C=C/C(OC)C(C(C)C(O)C(C)C2(O)CC(O)C(C)C(C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00008982_numbered.png,2026-03-19 06:58:36.070608
8310,ML00000810,CHEMBL2324847,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](CCCn3cc(C(C)(C)O)nn3)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8311,ML00002397,,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC(=O)C[C@@H]3SC[C@@H](C(=O)O)NC3=O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00002397_numbered.png,2026-03-19 06:58:36.125664
8312,ML00003412,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(=O)C2O)[C@@H](CC(OC)OC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003412_numbered.png,2026-03-19 06:58:36.179457
8313,ML00010950,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/C(=O)[C@@H](C)C[C@@H](CC)[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O)[C@@H](C)O2)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010950_numbered.png,2026-03-19 06:58:36.224308
8314,ML00010461,,,C[C@]1(O)CC[C@]23COC(=O)/C=C4\CCO[C@]5(CC/C=C\C(=O)O[C@@H]6C[C@H]7O[C@@H]2[C@@H]1C[C@@]7(O)[C@]63C)[C@@H](O)C(=O)O[C@H]45,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8315,ML00002745,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=C2OCCCO2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002745_numbered.png,2026-03-19 06:58:36.284509
8316,ML00005500,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCI)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005500_numbered.png,2026-03-19 06:58:36.338135
8317,ML00002541,,,CCN(CC)Cc1ccc([C@H](Cl)[C@H](O)[C@@H](C)[C@@H]2C/C=C/C(=O)N[C@H](Cc3ccc(OC)c(Cl)c3)C(=O)NCC(C)(C)C(=O)O[C@@H](CC(C)C)C(=O)O2)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8318,ML00009946,,,C/C(=C\c1ccc(C)cn1)[C@@H]1C[C@@H]2C[C@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00009946_numbered.png,2026-03-19 06:58:36.389491
8319,ML00006961,,,CC1CC2CCC(O2)C(C)C(=O)OC(C)CC2CCC(O2)C(C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8320,ML00000757,CHEMBL2324841,,C=CCOCCC[C@H]1CNC(=O)[C@@H](Cc2ccc(OC)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8321,ML00009534,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009534_numbered.png,2026-03-19 06:58:36.453788
8322,ML00010647,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(O)C#Cc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8323,ML00002085,CHEMBL4095879,,Cc1cc2cc(C)c1CCOC(=O)Nc1cccc(c1)[C@@H](CC(=O)O)NC(=O)[C@@H]2Nc1ccc2cc[nH]c(=O)c2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8324,ML00005604,,,CCCCC(=O)O[C@@H]1[C@@H](C)O[C@@H](O[C@H]2[C@H](C)O[C@H](O[C@H]3[C@@H](OC)[C@@H](OC(C)=O)CC(=O)O[C@@H](C)C/C=C\C=C/[C@@H](OC(=O)CC)[C@@H](C)C[C@@H]3CC=O)[C@@H](O)[C@@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005604_numbered.png,2026-03-19 06:58:36.512353
8325,ML00010437,,,CC(=O)O[C@H]1C[C@@]23COC(=O)[C@H]4O[C@@]45CCO/C(=C/C/C=C\C(=O)O[C@@H]4C[C@@H](O[C@@H]2C=C1C)[C@@]1(CO1)[C@]43C)[C@@H]5O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8326,ML00003500,,,CC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 6, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00003500_numbered.png,2026-03-19 06:58:36.566493
8327,ML00008779,,,CO[C@H]1CCCCCCCCC[C@@H](C)OC(=O)C2CC2C1=O,standard_macrolactone,16.0,,,success,,3.0,"[3, 13, 14]",ring_size_16/standard/numbered/ML00008779_numbered.png,2026-03-19 06:58:36.595383
8328,ML00002332,,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(=O)CC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002332_numbered.png,2026-03-19 06:58:36.640715
8329,ML00008396,,,CC(=O)C[C@@H]1CC[C@H](O)/C=C\C(=O)O[C@H](CC(C)=O)CC[C@@H](O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8330,ML00001096,CHEMBL3809909,,CC1(C)COC(=O)Nc2cccc(c2)CNC(=O)[C@H](Nc2ccc3c(N)nccc3c2)c2ccc1cc2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8331,ML00006871,,,CC(C)[C@H]1NC(=O)C(C)(C)NC(=O)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCS)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8332,ML00007291,,,CC(C)[C@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)[C@@H](Cc2ccccc2)NC(=O)C[C@@H](/C=C/CCS)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8333,ML00003265,,,CCCC/C=C/C(=O)N[C@@H](Cc1cccc(F)c1)C(=O)N[C@@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)C2(CCCC2)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8334,ML00000751,CHEMBL492459,CRYPTOPHYCIN 46,COc1ccc(C[C@@H]2NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8335,ML00003902,,,COC1C(O)CC(=O)OC(C)C/C=C\C=C/C(=O)C(C)CC(CC=O)C1OC1OC(C)C(OC2CC(C)(O)C(OC(=O)CC(C)C)C(C)O2)C(N(C)C)C1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003902_numbered.png,2026-03-19 06:58:36.738231
8336,ML00009302,,,CC(C)C[C@@H]1OC(=O)[C@H](C)CNC(=O)[C@@H](Cc2ccc(O)c(Cl)c2)NC(=O)/C=C\C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8337,ML00005765,,,CCC(=O)O[C@H]1/C=C\[C@H]2O[C@H]2C[C@@H](C)OC(=O)C[C@@H](OC(=O)CC)[C@@H](OC)[C@@H](O[C@H]2O[C@@H](C)[C@H](O[C@@H]3C[C@](C)(O)[C@H](OC(=O)CC)[C@@H](C)O3)[C@H](N(C)C)[C@@H]2O)[C@@H](CC=O)C[C@H]1C,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005765_numbered.png,2026-03-19 06:58:36.802175
8338,ML00001123,CHEMBL3892246,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1cc(F)c(O[C@@H]3COC[C@@H]3O)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8339,ML00004881,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](CCCc4cnc5ccccc5c4)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8340,ML00001400,CHEMBL3251855,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(C)=O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001400_numbered.png,2026-03-19 06:58:36.874261
8341,ML00001422,CHEMBL125768,,CCC1(CC)CNC(=O)[C@@H](Cc2ccc(OC)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8342,ML00010045,,,CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCSSC[C@H](NC(=O)OC(C)(C)C)C(=O)O)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8343,ML00002076,CHEMBL235645,,CN(c1cc2cc(n1)N(Cc1ccccc1)CCCCc1cccc(c1)C[C@@](C)(N)C(=O)OC2)S(C)(=O)=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8344,ML00000641,CHEMBL1939385,,Cc1cc(C)c2cc1C(=O)NCCNC(=O)OCCSc1cc-2nc(N)n1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8345,ML00007187,,,CCc1nc(/C=C(\C)[C@@H]2C[C@@H]3O[C@@H]3CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O2)cs1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007187_numbered.png,2026-03-19 06:58:36.955813
8346,ML00001134,CHEMBL1171466,,CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)C2=N[C@@](Cc3ccccc3)(CS2)C(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8347,ML00009058,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)C(=O)/C=C\[C@H](C)[C@H](O)C(C)C)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009058_numbered.png,2026-03-19 06:58:37.018394
8348,ML00004619,,,CCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](C/C=C/c4cnc5ccccc5c4)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(=O)CC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8349,ML00001303,CHEMBL3251866,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001303_numbered.png,2026-03-19 06:58:37.083371
8350,ML00008983,,,CO/C1=C/C(C)=C/C(C)C(O)C(C)C/C(C)=C/C=C/C(OC)C(C(C)C(O)C(C)C2(O)CC(O)C(C)C(C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00008983_numbered.png,2026-03-19 06:58:37.138142
8351,ML00010564,,,CC[C@H]1OC(=O)C[C@@H](O)[C@@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](CCO)C[C@H](C)C(=O)/C=C\C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010564_numbered.png,2026-03-19 06:58:37.199078
8352,ML00010440,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@]56OCC/C(=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)[C@H]5O[C@H](O)[C@H]6O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8353,ML00006902,,,CC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O)[C@@H](C)C[C@@H](C)C(=O)/C=C\C=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00006902_numbered.png,2026-03-19 06:58:37.255293
8354,ML00008958,,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)C(O)C[C@H](O)[C@H](C)C(O)C(C)C)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00008958_numbered.png,2026-03-19 06:58:37.305571
8355,ML00002022,CHEMBL3426552,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]2CCC[C@@H](C(=O)C(C)(C)[C@@H](O)CC(=O)O1)[C@H]2O,standard_macrolactone,16.0,,,success,,6.0,"[3, 11, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00002022_numbered.png,2026-03-19 06:58:37.346367
8356,ML00009642,,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](C(=O)OCN)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009642_numbered.png,2026-03-19 06:58:37.394057
8357,ML00004726,,,CC[C@@H]1[C@@H](C)O[C@@](OC)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C=C\C=C/[C@H](C)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]3(OC)C[C@@H](O[C@H]4C[C@H](O)[C@H](O)[C@H](C)O4)[C@H](C)[C@@H](C)O3)OC(=O)/C=C\C=C/[C@@H]2C)C[C@H]1OC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8358,ML00009436,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC(=O)Nc1ccc([N+](=O)[O-])cc1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009436_numbered.png,2026-03-19 06:58:37.453743
8359,ML00001173,CHEMBL95328,,C/C1=C/C[C@@H](c2ccc3c(c2)nc(C)n3C)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00001173_numbered.png,2026-03-19 06:58:37.502089
8360,ML00003418,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCI)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003418_numbered.png,2026-03-19 06:58:37.554077
8361,ML00000002,CHEMBL94657,PATUPILONE,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00000002_numbered.png,2026-03-19 06:58:37.604741
8362,ML00000608,CHEMBL3410866,,COc1ccc(C[C@@H]2NC(=O)/C=C/C[C@@H](c3ccc(Cl)cc3Cl)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8363,ML00003680,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003680_numbered.png,2026-03-19 06:58:37.671884
8364,ML00010620,,,COC1C(OCC2C(C)OC(=O)/C=C\C(C)C(OC3OC(C)CC(O)C3O)CCC(C)(O)C(=O)/C=C\C3OC32)OC(C)C(O)C1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 10, 13, 14]",ring_size_16/standard/numbered/ML00010620_numbered.png,2026-03-19 06:58:37.722582
8365,ML00005572,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc([N+](=O)[O-])cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005572_numbered.png,2026-03-19 06:58:37.785443
8366,ML00009621,,,CO[C@H]1[C@@H](OC(C)=O)CC(=O)O[C@H](C)C[C@@H]2O[C@@H]2/C=C\[C@H](O)[C@@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@@H](C)[C@H](O[C@H]2C[C@](C)(O)[C@H](O)[C@H](C)O2)[C@@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009621_numbered.png,2026-03-19 06:58:37.839074
8367,ML00009634,,,CC[C@@H]1OC(=O)/C=C\[C@H](C)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@H](C)C[C@@H](C)C(=O)/C=C\C=C/[C@@]1(O)CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009634_numbered.png,2026-03-19 06:58:37.897538
8368,ML00008883,,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCNC(CO)CO)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00008883_numbered.png,2026-03-19 06:58:37.957439
8369,ML00008880,,,COc1c(Cl)cc(C[C@H]2NC(=O)/C=C\C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8370,ML00009300,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(O)CCc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8371,ML00007690,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@H](O)[C@@H](Cl)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,10.0,"[3, 5, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007690_numbered.png,2026-03-19 06:58:38.034483
8372,ML00009929,,,CO[C@H]1CCCC[C@@H](c2ccccc2)OC(=O)[C@@H](C)[C@]2(O)O[C@@H]([C@@H](C)/C=C\[C@H]1OC)[C@@H](C)[C@H](O)[C@H]2OC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8373,ML00002301,,,CO[C@H]1[C@@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@](C)(O)[C@@H](OC(=O)CC(C)C)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H](CC=O)C[C@H](C)C(=O)/C=C\[C@H]2O[C@@H]2C[C@@H](C)OC(=O)C[C@H]1C(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002301_numbered.png,2026-03-19 06:58:38.098121
8374,ML00009259,,,CC(/C=C/C=C(\C)[C@H](O)[C@@H](C)[C@@H]1C[C@H](O)[C@@]2(C)O[C@@H]2/C=C\[C@@H](C)[C@H]2C[C@@H](C/C=C\C(=O)O1)CC(=O)O2)=C\c1coc(C)n1,standard_macrolactone,16.0,,,success,,4.0,"[3, 5, 6, 10]",ring_size_16/standard/numbered/ML00009259_numbered.png,2026-03-19 06:58:38.137590
8375,ML00006848,,,C/C=C1\NC(=O)[C@H]2CSSCC/C=C\[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8376,ML00007514,,,Cc1cccc(OCC(=O)ON=C2CCCCCCCCCCC(=O)OCCC2)c1C,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00007514_numbered.png,2026-03-19 06:58:38.171803
8377,ML00010332,,,CC/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00010332_numbered.png,2026-03-19 06:58:38.227824
8378,ML00009607,,,CO[C@H]1[C@H](OC[C@H]2/C=C/CCC(=O)[C@H](C)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@@]4(OC(=O)O[C@H]4C)[C@H]3O)[C@@H](C)/C=C/C(=O)O[C@@H]2C)O[C@H](C)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009607_numbered.png,2026-03-19 06:58:38.280917
8379,ML00008845,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8380,ML00003520,,,COC(=O)[C@H]1[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](C(=O)OC)[C@H](C)[C@@H](C(C)C)O2)OC(=O)/C(OC)=C/C(C)=C/[C@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00003520_numbered.png,2026-03-19 06:58:38.344388
8381,ML00010470,,,CC(=O)[C@@]12CC/C=C\C(=O)O[C@@H]3C[C@H]4O[C@@H]5C=C(C)CC[C@]5(COC(=O)[C@H]5O[C@]5(CCO1)[C@H]2O)[C@]3(C)[C@]41CO1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8382,ML00007519,,,CC(C)(Oc1ccc(Cl)cc1)C(=O)ON=C1CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00007519_numbered.png,2026-03-19 06:58:38.380256
8383,ML00009815,,,CCCC(=O)O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@@H](OC)[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]2CC=O)[C@H](O)[C@H]1N(C)C,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009815_numbered.png,2026-03-19 06:58:38.432962
8384,ML00001597,CHEMBL3244599,,CCC(=O)O[C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@H](OC)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)C(C)CC)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@H]1C,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001597_numbered.png,2026-03-19 06:58:38.487456
8385,ML00003431,,,CCCC(=O)OC1C(C)OC(OC2C(C)OC(O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CCN)C(O)C2N(C)C)CC1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003431_numbered.png,2026-03-19 06:58:38.539030
8386,ML00008978,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@H](C)C/C(C)=C\C=C/[C@H](OC)[C@H]([C@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00008978_numbered.png,2026-03-19 06:58:38.593631
8387,ML00009079,,,COC1/C=C\C=C(\C)CC(C)C(O)C(C)/C=C(C)\C=C(\C)C(=O)OC1C(C)C(O)C(C)C(=O)/C=C/C(C)C(O)C(C)C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009079_numbered.png,2026-03-19 06:58:38.644077
8388,ML00003722,,,CCC[C@@H]1OC(=O)[C@H](CC)[C@H]2CC[C@H](O2)[C@@H](C)[C@H]([C@H](CC)[C@H]2CC[C@@H](C[C@@H](CCC)N(C)C)O2)OC(=O)[C@@H](C)[C@H]2CC[C@H](O2)[C@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8389,ML00008818,,,COc1ccc(C[C@H]2NC(=O)/C=C\C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8390,ML00007674,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@H](O)[C@H](O)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)C(O)CC(=O)O1,standard_macrolactone,16.0,,,success,,10.0,"[3, 5, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007674_numbered.png,2026-03-19 06:58:38.719196
8391,ML00005699,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)/C(C)=C/C)C(C)C)[C@@H](C)OC(=O)[C@H](CCCc2ccc(O)cc2)NC(=O)[C@@H](CCC(=O)O)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8392,ML00003387,,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@H](CC=O)C[C@@H](C)[C@@H](O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H]3OC)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003387_numbered.png,2026-03-19 06:58:38.782217
8393,ML00003392,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003392_numbered.png,2026-03-19 06:58:38.843299
8394,ML00007890,,,CC(=O)C[C@@H]1CC(=O)O[C@@H](C)C/C=C\C(=O)O[C@H](C)[C@@H](O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8395,ML00008849,,,CO[C@@H](/C(C)=C/C=C/C(C)=C/c1coc(C)n1)[C@@H](C)[C@@H]1C[C@H](O)[C@@]2(C)O[C@@H]2/C=C\[C@@H](C)[C@H]2C[C@@H](C/C=C\C(=O)O1)CC(=O)O2,standard_macrolactone,16.0,,,success,,4.0,"[3, 5, 6, 10]",ring_size_16/standard/numbered/ML00008849_numbered.png,2026-03-19 06:58:38.886244
8396,ML00008878,,,COc1ccc(C[C@H]2NC(=O)C[C@H](O)C[C@@H]([C@H](C)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8397,ML00007504,,,C[C@@H]1CCCCCCCCC[C@H](OC(=O)CCC(=O)OC(C)(C)C)C(=O)c2[nH]ncc2C(=O)O1,standard_macrolactone,16.0,,,success,,3.0,"[3, 13, 14]",ring_size_16/standard/numbered/ML00007504_numbered.png,2026-03-19 06:58:38.922101
8398,ML00010883,,,CC[C@@H]1OC(=O)C[C@H](O)[C@@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\[C@H]2O[C@@H]2[C@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010883_numbered.png,2026-03-19 06:58:38.969327
8399,ML00007512,,,Cc1ccc(OC(C)C(=O)ON=C2CCCCCCCCCCC(=O)OCCC2)cc1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00007512_numbered.png,2026-03-19 06:58:38.992024
8400,ML00009167,,,C#CCOC[C@H]1/C=C(C)/C=C/C(=O)[C@H](C)CC(C=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O)CC(=O)O[C@@H]1CC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009167_numbered.png,2026-03-19 06:58:39.041713
8401,ML00008751,,,CC[C@H](O)[C@@H]1C/C=C\C/C=C\C/C=C\CCCCC(=O)O1,standard_macrolactone,16.0,,,success,,1.0,[3],ring_size_16/standard/numbered/ML00008751_numbered.png,2026-03-19 06:58:39.064104
8402,ML00009276,,,CCC1OC(=O)CC(O)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C/C=C/C(C)=O)CC(C)C(=O)/C=C\C2(C)OC2C1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009276_numbered.png,2026-03-19 06:58:39.112954
8403,ML00009795,,,CO[C@H]1[C@H](OC[C@H]2/C=C/CCC(=O)[C@H](C)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@](O)([C@H](C)O)[C@H]3O)[C@@H](C)/C=C/C(=O)O[C@@H]2C)O[C@H](C)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009795_numbered.png,2026-03-19 06:58:39.157428
8404,ML00008435,,,C[C@@H]1CCCCCCCCC[C@H](OC(=O)CCC(=O)O)C(=O)/C=C/C(=O)O1,standard_macrolactone,16.0,,,success,,3.0,"[3, 13, 14]",ring_size_16/standard/numbered/ML00008435_numbered.png,2026-03-19 06:58:39.185428
8405,ML00010885,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010885_numbered.png,2026-03-19 06:58:39.235110
8406,ML00010563,,,CC[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](C)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010563_numbered.png,2026-03-19 06:58:39.284558
8407,ML00009628,,,CC[C@@H]1OC(=O)/C=C\[C@H](C)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@H](C)C[C@H](C)C(=O)/C=C\[C@H]2O[C@H]2[C@@]1(O)CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009628_numbered.png,2026-03-19 06:58:39.332698
8408,ML00010217,,,O=C(NC1CCCCCCCCCCC(=O)OCCC1)NS(=O)(=O)C1CCCCCCCCCCC1=O,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00010217_numbered.png,2026-03-19 06:58:39.355810
8409,ML00004386,,,CC[C@H]1[C@H](O[C@H]2C[C@H](O)[C@H](O)[C@H](C)O2)C=C([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C=C/C=C/[C@H](C)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]3(O)C[C@@H](O[C@H]4C[C@H](O)[C@H](O)[C@H](C)O4)[C@H](CC)[C@@H](C)O3)OC(=O)/C=C/C=C/[C@@H]2C)O[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8410,ML00003426,,,CC[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](CO[C@@H]2O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]2OC)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003426_numbered.png,2026-03-19 06:58:39.417567
8411,ML00005985,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=O)/C=C/C=C/[C@@H]1CNN1CC(C)CC(C)C1,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005985_numbered.png,2026-03-19 06:58:39.475060
8412,ML00010142,,,O=C1C[C@H](c2ccc(O)cc2)c2c(O)cc(O)c3c(=O)c(O)c(oc23)-c2cc(O)c(O)c(c2)O[C@@H]2O[C@H](CO1)[C@@H](O)[C@H](O)[C@H]2O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8413,ML00002810,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=N/OCC(=O)N2CCN(c3ccccc3)CC2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002810_numbered.png,2026-03-19 06:58:39.539233
8414,ML00003547,,,C/C=C/C=C/C=C/C(=O)NC(Cc1ccccc1)C(=O)NC1COC(=O)C2CC(C)CN2C(=O)C(C)NC(=O)C(C)N(C)C(=O)C2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8415,ML00002924,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O[C@H]2CC[C@H](N(C)C)[C@H](C)O2)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002924_numbered.png,2026-03-19 06:58:39.594020
8416,ML00006687,,,CC1CCCC(C2CNC(N)=N2)C(=O)OCC(C)CCCC(C2CNC(N)=N2)C(=O)OC1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8417,ML00007628,,,CCC[C@@H]1OC(=O)[C@@H](C)[C@H]2CC[C@H](O2)[C@@H](C)[C@H](CCC)OC(=O)[C@@H](C)[C@H]2CC[C@H](O2)[C@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8418,ML00007043,,,CC(=O)SCC/C=C/[C@H]1CC(=O)N[C@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)NCC(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8419,ML00002677,,,CCCC(=O)OC1C(C)OC(OC2C(C)OC(OC3C(CC=O)CC(C)C(O)/C=C\C=C/CC(C)OC(=O)CC(OC(C)=O)C3OC)C(O)C2N(C)C)CC1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002677_numbered.png,2026-03-19 06:58:39.657183
8420,ML00006393,,,CCC1OC(=O)CC(O)C(C)C(OC2CC(N(C)C)C(OC3CC(C)(O)C(O)C(C)O3)C(C)O2)C(CC=O)CC(C)C(=O)/C=C\C2(C)OC2C1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006393_numbered.png,2026-03-19 06:58:39.710671
8421,ML00002728,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C[C@@H]2O[C@@H]2/C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](OC(=O)CC(C)C)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002728_numbered.png,2026-03-19 06:58:39.759176
8422,ML00007081,,,CC[C@@H]1C[C@H]2CC[C@H](O2)[C@H](C)C(=O)O[C@H](C)C[C@H]2CC[C@H](O2)[C@H](C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8423,ML00009848,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@@H](C)[C@]2(O)C[C@H](OC)[C@@H](C)[C@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009848_numbered.png,2026-03-19 06:58:39.811508
8424,ML00003899,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C[C@@H](O)/C=C\C=C/[C@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](OC(C)=O)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 5, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003899_numbered.png,2026-03-19 06:58:39.859078
8425,ML00010246,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@]56OCC[C@@]7(O[C@H]7C(=O)OC[C@@]2(CC1)[C@]4(C)[C@@]31CO1)[C@H]5OC(=O)[C@H]6O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8426,ML00008973,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@H](O)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](C(C)=O)C[C@@H](C)[C@@H](O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00008973_numbered.png,2026-03-19 06:58:39.911853
8427,ML00002524,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)/C(C)=C/C)C(C)C)[C@@H](C)OC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(=O)O)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8428,ML00000398,CHEMBL3410864,,COc1ccc(C[C@@H]2NC(=O)/C=C/C[C@@H](c3cccc([N+](=O)[O-])c3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8429,ML00006105,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)CC[C@@H](C/C=C2\SCCN2Cc2ccccc2)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 6, 9, 10, 13, 14, 15]",ring_size_16/standard/numbered/ML00006105_numbered.png,2026-03-19 06:58:39.975601
8430,ML00002845,,,C=C[C@@H]1[C@H]2/C=C/C=C\CC(=O)O[C@]34C[C@H](C)[C@]5(O)[C@H](C=C(CO)C[C@@]6(O)C(=O)C(C)=C[C@@H]65)[C@H]3[C@]4(C)COC(=O)/C=C\[C@H]2[C@@H]1/C=C/C=C/C=C/CCC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8431,ML00007607,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C/C=C5/OCC[C@@]6(O[C@@H]6C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)[C@H]5O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8432,ML00003893,,,CCC(=O)O[C@H]1CC(=O)O[C@H](C)C[C@@H]2O[C@@H]2/C=C\[C@H](O)[C@@H](C)C[C@H](CC=O)[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@](C)(O)[C@@H](OC(C)=O)[C@@H](C)O3)[C@@H](C)O2)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003893_numbered.png,2026-03-19 06:58:40.034135
8433,ML00004826,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc(C=O)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004826_numbered.png,2026-03-19 06:58:40.089162
8434,ML00009508,,,CCC[C@@H]1OC(=O)[C@H](CC)[C@H]2CC[C@@H](C[C@H]([C@H](C)[C@H]3CC[C@@H](C[C@@H](CCC)N(C)C)O3)OC(=O)[C@@H](C)[C@H]3CC[C@H](O3)[C@H]1C)O2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8435,ML00009084,,,CO[C@@H]1[C@@H](OC[C@@H]2[C@H](C)OC(=O)/C=C\[C@H](C)[C@H](O[C@H]3O[C@@H](C)C[C@@H](OC)[C@@H]3O)[C@H](C)C[C@@](C)(O)C(=O)/C=C\[C@H]3O[C@@H]32)O[C@@H](C)[C@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009084_numbered.png,2026-03-19 06:58:40.143130
8436,ML00004901,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCCc4ccncc4)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004901_numbered.png,2026-03-19 06:58:40.197387
8437,ML00009408,,,C/C=C/C=C/[C@H](O)[C@@H](C)/C=C/C(=O)[C@@H](C)[C@H](O)[C@H](C)[C@H]1OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009408_numbered.png,2026-03-19 06:58:40.242895
8438,ML00006291,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](C)[C@H](O)CC(=O)O[C@H](CC)[C@@H](CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC)/C=C(C)\C=C/C(=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006291_numbered.png,2026-03-19 06:58:40.296611
8439,ML00001146,CHEMBL540728,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2OC(c3ccc(C)cc3)=N[C@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00001146_numbered.png,2026-03-19 06:58:40.342353
8440,ML00002041,CHEMBL250918,,CN(c1cc2cc(c1)C(=O)N[C@@H](c1ccccc1)CCc1cccc(c1)C[C@@](C)(N)C(=O)OC2)S(=O)(=O)C(F)(F)F,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8441,ML00004385,,,CC[C@H]1[C@H](O[C@H]2C[C@H](O)[C@H](O)[C@H](C)O2)C=C([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C=C\C=C/[C@H](C)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]3(O)C[C@@H](O[C@H]4C[C@H](O)[C@H](O)[C@H](C)O4)[C@H](CC)[C@@H](C)O3)OC(=O)/C=C\C=C/C2C)O[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8442,ML00004853,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)OCCC(/C=C\Cc4ccnc5ccccc45)CN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8443,ML00002049,CHEMBL3799929,,CC(=O)N[C@H](C)[C@@H](O)[C@@H](C)[C@@H]1OC(=O)/C=C/C=C(C)\C=C\c2ccccc2/C=C(C)/C=C/[C@H]1C,standard_macrolactone,16.0,,,success,,4.0,"[3, 4, 7, 13]",ring_size_16/standard/numbered/ML00002049_numbered.png,2026-03-19 06:58:40.396403
8444,ML00004143,,,CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H]1C(=O)N2CCC[C@H]2C(=O)N2CC[C@H](C)C[C@H]2C(=O)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)O[C@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8445,ML00010153,,,C[C@@H]1CCCCCCCCC[C@H](OC(=O)CCC(=O)OC(C)(C)C)C(=O)CC(N2CCN(C)CC2)C(=O)O1,standard_macrolactone,16.0,,,success,,4.0,"[3, 13, 14, 16]",ring_size_16/standard/numbered/ML00010153_numbered.png,2026-03-19 06:58:40.437183
8446,ML00007494,,,Cc1nc(/C=C/[C@@H]2C/C=C\CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O2)cs1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007494_numbered.png,2026-03-19 06:58:40.485596
8447,ML00006189,,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccc(NC(=O)OCC3c4ccccc4-c4ccccc43)cc2)NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8448,ML00003420,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@H](OC)[C@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC(=O)/C=C/C(=O)O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00003420_numbered.png,2026-03-19 06:58:40.548181
8449,ML00010523,,,CC(=O)NCCCC[C@H]1C(=O)C(C)(C)[C@@H](O)CC(=O)O[C@H](/C(C)=C/c2csc(C)n2)C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00010523_numbered.png,2026-03-19 06:58:40.605302
8450,ML00003269,,,CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H]1C(=O)N2CCC[C@H]2C(=O)N2CCCC[C@H]2C(=O)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)O[C@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8451,ML00005649,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCS(=O)(=O)c2ccc(C)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005649_numbered.png,2026-03-19 06:58:40.678987
8452,ML00009388,,,C/C=C\C=C\C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8453,ML00003778,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@H]3[C@H](CC=O)C[C@@H](C)[C@@H](O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H]3OC)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003778_numbered.png,2026-03-19 06:58:40.740569
8454,ML00003550,,,CC(C)C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)/C=C/C=C/C=C/C=C/c2ccc(O)c(Br)c2)[C@@H](C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8455,ML00000406,CHEMBL3410863,,COc1ccc(C[C@@H]2NC(=O)/C=C/C[C@@H](c3ccc([N+](=O)[O-])cc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8456,ML00004418,,,CCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](C/C=C/c4cnc5ccccc5c4)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(=O)CC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8457,ML00009490,,,CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)C2=N[C@@](C)(CS2)C(=O)N[C@@H](Cc2cccc3ccccc23)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8458,ML00002108,CHEMBL1790732,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H]([C@H](C)O)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8459,ML00002624,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/C(=O)[C@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](OC(=O)CC)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002624_numbered.png,2026-03-19 06:58:40.837515
8460,ML00006436,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CCCCCCC2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006436_numbered.png,2026-03-19 06:58:40.900212
8461,ML00006387,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCF)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006387_numbered.png,2026-03-19 06:58:40.965771
8462,ML00005503,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005503_numbered.png,2026-03-19 06:58:41.030638
8463,ML00004240,,,CO/C1=C/C(C)=C\C(C)C(O)C(C)C/C(C)=C\C=C/C(OC)C(C(C)C(O)C(C)C2(OC)CC(OC(=O)/C=C/C(=O)O)C(C)C(C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00004240_numbered.png,2026-03-19 06:58:41.085665
8464,ML00001128,CHEMBL4108209,,CCS(=O)(=O)c1ccc2cc1CNC(=O)[C@H](Nc1ccc3c(N)nccc3c1)c1ccc(cc1)CCOC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8465,ML00000717,CHEMBL452431,CRYPTOPHYCIN 176,CC(C)C[C@@H]1OC(=O)CCNC(=O)[C@@H](Cc2ccc(O)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8466,ML00006380,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006380_numbered.png,2026-03-19 06:58:41.165251
8467,ML00000170,CHEMBL196498,,CSc1nc(/C=C(\C)[C@@H]2C[C@@H]3C[C@@]3(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)CCC(=O)O2)cs1,standard_macrolactone,16.0,,,success,,8.0,"[3, 6, 10, 11, 12, 13, 14, 14]",ring_size_16/standard/numbered/ML00000170_numbered.png,2026-03-19 06:58:41.217363
8468,ML00006053,,,CC[C@@H]1OC(=O)C[C@@H](OC(C)=O)[C@H](C)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H](CC=O)C[C@@H](C)[C@@H](O[C@@H]2CC[C@@H](N(C)C)[C@H](C)O2)/C=C\C(C)=C/[C@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006053_numbered.png,2026-03-19 06:58:41.281127
8469,ML00001197,CHEMBL3973659,,Cc1cc2ccc1[C@@H](CF)COC(=O)Nc1ccc(S(=O)(=O)C3CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8470,ML00009242,,,CC[C@@H]1OC(=O)C[C@@](O)(C/C=C/C=C(\C)[C@@H]2OC(=O)CC/C=C(/C)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](OC(N)=O)/C=C\C=C/[C@@H]2C)[C@H]1C,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 11, 12, 13]",ring_size_16/standard/numbered/ML00009242_numbered.png,2026-03-19 06:58:41.337968
8471,ML00002013,CHEMBL89619,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccc(N)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8472,ML00001417,CHEMBL102700,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c3cc(C)ccc3C)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8473,ML00002140,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=N/OC/C=C\c2ccc3nccnc3c2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002140_numbered.png,2026-03-19 06:58:41.414719
8474,ML00009922,,,COC(=O)C[C@@H]1C/C=C\C(=O)O[C@@H]([C@H](C)[C@@H](OC)/C(C)=C/C=C/C(C)=C/c2coc(C)n2)C[C@H](O)[C@]2(C)O[C@@H]2/C=C\[C@@H](C)[C@H](O)C1,standard_macrolactone,16.0,,,success,,6.0,"[3, 5, 6, 10, 11, 13]",ring_size_16/standard/numbered/ML00009922_numbered.png,2026-03-19 06:58:41.455821
8475,ML00002039,CHEMBL551685,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@H]2[C@@H](CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)N2CCO,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00002039_numbered.png,2026-03-19 06:58:41.502738
8476,ML00003061,,,CC[C@H]1C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](OC(C)=O)[C@H](OC)[C@H]1OC1OC(C)C(OC2CC(C)(O)C(OC(=O)CC(C)C)C(C)O2)C(N(C)C)C1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003061_numbered.png,2026-03-19 06:58:41.548018
8477,ML00009265,,,COc1c(Cl)cc(C[C@H]2NC(=O)/C=C\C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8478,ML00006937,,,CCC1CC(C)C(O)/C=C\C=C/CC(C)OC(=O)CC(O)C(OC)C1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006937_numbered.png,2026-03-19 06:58:41.596304
8479,ML00006566,,,CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CCCCCCCCCCCCCCCCCCN=C(N)N)[C@@H](C)OC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCN)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8480,ML00009141,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(=O)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8481,ML00003429,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCO[N+](=O)[O-])C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003429_numbered.png,2026-03-19 06:58:41.666031
8482,ML00006901,,,CC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O)[C@H](C)C[C@@H](C)C(=O)/C=C\C=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00006901_numbered.png,2026-03-19 06:58:41.708788
8483,ML00008541,,,CCO[C@H]1CC(=O)[C@@H](C)OC(=O)C[C@H](C)OC(=O)/C=C\[C@@H](O)[C@H](C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8484,ML00002673,,,CCC(=O)O[C@H]1CC(=O)O[C@@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@@H](CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@H](OC(=O)CC)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002673_numbered.png,2026-03-19 06:58:41.763594
8485,ML00000271,CHEMBL401180,,C[C@@]1(N)Cc2cccc(c2)CC[C@H](c2ccccc2)NC(=O)c2cc(cc(-c3ccccc3C#N)c2)COC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8486,ML00000074,CHEMBL13529,CRYPTOPHYCIN 3,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8487,ML00007040,,,CC1CCC(NS(=O)(=O)c2ccc(F)cc2)CCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/ML00007040_numbered.png,2026-03-19 06:58:41.802666
8488,ML00006425,,,CC[C@@H]1OC(=O)C[C@@H](O)[C@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H](O[C@@H]3C[C@@](C)(O)[C@H](O)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@H](CCO)C[C@@H](C)[C@@H](O)/C=C\C(C)=C/[C@H]1CO[C@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006425_numbered.png,2026-03-19 06:58:41.857626
8489,ML00002555,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CCCCC2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CN1CCCCC1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002555_numbered.png,2026-03-19 06:58:41.911875
8490,ML00002014,CHEMBL87165,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8491,ML00001097,CHEMBL3951355,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(C(=O)N3CCC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8492,ML00004136,,,CCCC/C=C/C(=O)N[C@@H](Cc1cccc(F)c1)C(=O)N[C@@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)C2(CCCCC2)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8493,ML00001168,CHEMBL3809993,,CN1Cc2cccc(c2)NC(=O)OCC(C)(C)c2ccc(cc2)[C@H](Nc2ccc3c(N)nccc3c2)C1=O,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8494,ML00004380,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCNCCc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004380_numbered.png,2026-03-19 06:58:42.000712
8495,ML00006482,,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)/C(C)=C/C)C(C)C)[C@@H](C)OC(=O)[C@H](CCCCc2ccc(O)cc2)NC(=O)[C@@H](CCC(=O)OC)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8496,ML00004863,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)OCCC(/C=C/Cc4cccc5cccnc45)CN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8497,ML00001778,CHEMBL3628311,,CC(C)[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)N(C)Cc1ccccc1CC(=O)O2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8498,ML00003772,,,CCC(=O)O[C@H]1CC(=O)O[C@@H](C)[C@@H](O)/C=C\C=C/[C@@H](O)[C@@H](C)C[C@H](CC=O)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003772_numbered.png,2026-03-19 06:58:42.077860
8499,ML00010315,,,CO[C@H]1/C=C\C(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,6.0,"[3, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00010315_numbered.png,2026-03-19 06:58:42.121319
8500,ML00001424,CHEMBL333531,,CCC1(CC)CNC(=O)[C@@H](Cc2ccc(OC)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c2ccccc2)OC(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8501,ML00010139,,,O=C1C[C@@H](c2ccc(O)cc2)c2c(O)cc(O)c3c(=O)c(O)c(oc23)-c2cc(O)c(O)c(c2)O[C@@H]2O[C@H](CO1)[C@@H](O)[C@H](O)[C@H]2O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8502,ML00006034,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@H](OCC[C@H]([C@H](OCC[C@@](C)(O)[C@H](O)[C@H](C)OC)[C@H](C)OC)N(C)C)[C@H](CC=O)C[C@H](C)C(=O)/C=C\[C@]2(C)O[C@H]2[C@@H]1CO[C@H]1O[C@@H](C)[C@H](O)[C@@H](OC)[C@@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006034_numbered.png,2026-03-19 06:58:42.188114
8503,ML00007661,,,C/C(=C\c1csc(C)n1)[C@@H]1C/C=C\CC/C=C(\C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007661_numbered.png,2026-03-19 06:58:42.233197
8504,ML00010331,,,CCc1nc(/C=C(\C)[C@@H]2C[C@@H]3O[C@]3(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O2)cs1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00010331_numbered.png,2026-03-19 06:58:42.281063
8505,ML00009085,,,CO[C@@H]1C[C@H](C)O[C@H](O[C@H]2[C@@H](C)/C=C\C(=O)O[C@@H](C)[C@@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)[C@@H]3O[C@@H]3/C=C\C(=O)[C@@](C)(O)C[C@H]2C)[C@H]1O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009085_numbered.png,2026-03-19 06:58:42.329436
8506,ML00002324,,,CO[C@H]1[C@@H](OC(C)=O)CC(=O)O[C@@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@H](CC=O)[C@H]1O[C@H]1O[C@H](C)[C@@H](O[C@@H]2C[C@](C)(O)[C@H](OC(=O)CC(C)C)[C@@H](C)O2)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002324_numbered.png,2026-03-19 06:58:42.375544
8507,ML00011009,,,C/C=C/CC(=O)[C@@H](C)[C@H](O)[C@H](C)[C@H]1OC(=O)/C(OC)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00011009_numbered.png,2026-03-19 06:58:42.420380
8508,ML00004462,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CCCCCCC2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004462_numbered.png,2026-03-19 06:58:42.474814
8509,ML00001361,CHEMBL331014,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccccc3)OC(=O)[C@H](CC(C)C)NC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8510,ML00005856,,,CO/C1=C/C(C)=C\[C@@H](C)[C@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@@H](C)C(=O)C[C@H](OC(=O)/C=C/C(=O)NC2=C(O)CCC2=O)[C@H](C)[C@H](O)C(C)C)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00005856_numbered.png,2026-03-19 06:58:42.528751
8511,ML00001133,CHEMBL555516,,CCc1ccc(C2=N[C@H]3CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O[C@H](/C(C)=C/c4csc(C)n4)C[C@@H]3O2)cc1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00001133_numbered.png,2026-03-19 06:58:42.574428
8512,ML00000843,CHEMBL2324846,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](CCCCN=[N+]=[N-])CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8513,ML00009415,,,C/C=C1\NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@@H](C)C[C@@H](C)CCC)[C@@H](C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8514,ML00003783,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](O)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003783_numbered.png,2026-03-19 06:58:42.639872
8515,ML00002080,CHEMBL1784527,TURNAGAINOLIDE A,CC[C@H](C)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@H](C(C)C)NC(=O)C[C@H](/C=C/c2ccccc2)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8516,ML00003684,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCO)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003684_numbered.png,2026-03-19 06:58:42.697052
8517,ML00009176,,,CO[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2C/C=C\C(=O)O[C@@H](C)[C@@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)[C@@H]3O[C@@H]3/C=C\C(=O)[C@](C)(O)CC2)[C@@H]1O,standard_macrolactone,16.0,,,success,,6.0,"[3, 4, 9, 10, 10, 13]",ring_size_16/standard/numbered/ML00009176_numbered.png,2026-03-19 06:58:42.737783
8518,ML00006813,,,CC1CCC(=NOC(=O)COc2ccc(Br)cc2Cl)CCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/ML00006813_numbered.png,2026-03-19 06:58:42.762965
8519,ML00002903,,,CCOC(C[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](CO[C@@H]2O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]2OC)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]1O)OCC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002903_numbered.png,2026-03-19 06:58:42.815344
8520,ML00008886,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C[C@@H](O)SC[C@H](N)C(=O)O)C[C@@H](C)C(=O)CC[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00008886_numbered.png,2026-03-19 06:58:42.867722
8521,ML00006106,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](OC(=O)NCCc3ccccc3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006106_numbered.png,2026-03-19 06:58:42.921737
8522,ML00006145,,,CCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@@H](C/C=C/c4ccc(N)nc4)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(=O)CC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8523,ML00008884,,,CCC[C@H]1C[C@@H]2CC[C@@H](O2)[C@H](C)C(=O)O[C@@H]([C@H](C)[C@H]2CC[C@@H](C[C@@H](CCC)N(C)C)O2)C[C@@H]2CC[C@@H](O2)[C@@H](C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8524,ML00009424,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC(=O)/C=C/C(=O)O)[C@H](C)[C@@H](C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009424_numbered.png,2026-03-19 06:58:42.982238
8525,ML00006666,,,CC(C)[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)Nc1cccc(c1)CC(=O)O2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8526,ML00001142,CHEMBL3913920,,[C-]#[N+]C1(COc2c(F)cc3cc2CN(C)C(=O)[C@H](Nc2ccc4c(N)nccc4c2)c2ccc(c(C)c2)[C@@H](C)COC(=O)N3)CC1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8527,ML00000151,CHEMBL364897,,C/C(=C\c1cccc(C)n1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00000151_numbered.png,2026-03-19 06:58:43.042967
8528,ML00004236,,,CO/C1=C/C(C)=C\[C@@H](C)[C@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@@]2(OC)C[C@@H](OC(=O)/C=C/C(=O)O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00004236_numbered.png,2026-03-19 06:58:43.088912
8529,ML00002658,,,CCC(=O)O[C@H]1CC(=O)O[C@H](C)C[C@@H]2O[C@@H]2/C=C\[C@H](O)[C@@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](OC(=O)CC)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002658_numbered.png,2026-03-19 06:58:43.136980
8530,ML00009020,,,CO[C@H]1[C@@H](C)CO[C@@H](O[C@H]2[C@@H](C)C[C@](C)(O)C(=O)CC[C@@H]3O[C@H]3[C@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)[C@@H](C)OC(=O)/C=C\[C@H]2C)[C@@H]1O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009020_numbered.png,2026-03-19 06:58:43.184537
8531,ML00009078,,,CO[C@@H]1/C=C\C=C(\C)C[C@H](C)[C@H](O)[C@@H](C)/C=C(C)\C=C(\C)C(=O)O[C@@H]1[C@H](C)[C@H](O)[C@@H](C)C(=O)/C=C/[C@H](C)[C@H](O)C(C)C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009078_numbered.png,2026-03-19 06:58:43.229468
8532,ML00010938,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00010938_numbered.png,2026-03-19 06:58:43.280519
8533,ML00008828,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8534,ML00000392,CHEMBL3622728,,C/C=C1\NC(=O)c2csc(n2)[C@@H](C(C)C)NC(=O)C[C@@H](/C=C/CCSC(=O)CCCCCCC)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8535,ML00008480,,,CC(=O)CC1CCC(=O)/C=C/C(=O)OC(CC(C)=O)CCC(=O)/C=C/C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8536,ML00004912,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](CCCc4ccnc5ccccc45)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8537,ML00002851,,,CCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](CC)NC(=O)[C@@H]2c3ccccc3CCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8538,ML00008723,,,O=C1CCCCCCC=CCCOC(=O)c2c(O)cc(O)c(Cl)c2C1,standard_macrolactone,16.0,,,success,,1.0,[13],ring_size_16/standard/numbered/ML00008723_numbered.png,2026-03-19 06:58:43.349350
8539,ML00004237,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(OC)C[C@@H](OC(=O)/C=C/C(=O)O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00004237_numbered.png,2026-03-19 06:58:43.411308
8540,ML00001282,CHEMBL224436,JOSAMYCIN,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001282_numbered.png,2026-03-19 06:58:43.465767
8541,ML00000071,CHEMBL3797512,,CC(=O)N[C@H](C)[C@@H](O)[C@@H](C)[C@@H]1OC(=O)/C=C/C=C(C)\C=C\[C@]2(C)CCC=C[C@@H]2/C=C(C)/C=C/[C@H]1C,standard_macrolactone,16.0,,,success,,5.0,"[3, 4, 7, 10, 13]",ring_size_16/standard/numbered/ML00000071_numbered.png,2026-03-19 06:58:43.508380
8542,ML00001595,CHEMBL3244432,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](N(C)C)[C@@H](OC(=O)CCC(=O)O)[C@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)O[C@@H]2C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001595_numbered.png,2026-03-19 06:58:43.562266
8543,ML00003231,,,C[C@@H]1NC(=O)[C@@H]2CCCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)/C=C/CC2CCCCC2)[C@H](C)OC(=O)[C@@H]2C[C@@H](C)CN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8544,ML00002035,CHEMBL2425898,,C/C1=C\C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)CC1,standard_macrolactone,16.0,,,success,,10.0,"[3, 6, 9, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00002035_numbered.png,2026-03-19 06:58:43.627090
8545,ML00007696,,,C/C(=C\c1csc(C)n1)[C@H]1OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC/C=C\[C@@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007696_numbered.png,2026-03-19 06:58:43.677987
8546,ML00000919,CHEMBL3326016,,CC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C=C(\C)CC/C=C(\C)CCCOC(=O)CCCCCCCCC(=O)O[C@H]1[C@@H](C)CCC[C@H]2O[C@H]2C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00000919_numbered.png,2026-03-19 06:58:43.726567
8547,ML00004642,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004642_numbered.png,2026-03-19 06:58:43.784174
8548,ML00000094,CHEMBL3329622,,CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCSSC[C@H](NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8549,ML00003428,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCO)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003428_numbered.png,2026-03-19 06:58:43.852293
8550,ML00009213,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC(C)=O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009213_numbered.png,2026-03-19 06:58:43.912135
8551,ML00006903,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)C(=O)[C@@H](C)C[C@@H](C)C(=O)/C=C\C=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006903_numbered.png,2026-03-19 06:58:43.965372
8552,ML00009273,,,CCC(=O)O[C@H]1[C@@H](O[C@@H]2[C@@H](C)[C@H](O)CC(=O)O[C@H](CC)[C@@H](C)[C@@H]3O[C@@]3(C)/C=C\C(=O)[C@H](C)C[C@@H]2CC=O)O[C@@H](C)C[C@H]1N(C)C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009273_numbered.png,2026-03-19 06:58:44.024986
8553,ML00004584,,,CC[C@@H]1[C@@H](C)O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C=C/C=C/[C@H](C)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]3(OC)C[C@@H](O[C@H]4C[C@H](O)[C@H](O)[C@H](C)O4)[C@H](CC)[C@@H](C)O3)OC(=O)/C=C/C=C/[C@@H]2C)C[C@H]1O[C@H]1C[C@H](O)[C@H](O)[C@H](C)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8554,ML00007632,,,Cc1cc(OC(C)(C)C(=O)ON=C2CCCCCCCCCCC(=O)OCCC2)ccc1Cl,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00007632_numbered.png,2026-03-19 06:58:44.057568
8555,ML00009448,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccc(CO)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8556,ML00002844,,,C=C[C@@H]1[C@H]2/C=C\C=C/CC(=O)O[C@@]34C[C@@H](C)[C@@]5(O)[C@@H](C=C(CO)C[C@]6(O)C(=O)C(C)=C[C@H]65)[C@@H]3[C@@]4(C)COC(=O)/C=C\[C@H]2[C@H]1/C=C/C=C/C=C/CCC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8557,ML00010858,,,CO[C@H]1/C=C\C(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(C)=O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,6.0,"[3, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00010858_numbered.png,2026-03-19 06:58:44.113379
8558,ML00003569,,,CC[C@@H]1O[C@](O)([C@H](C)[C@H](O)[C@H](C)[C@@H]2OC(=O)/C(C)=C\C(C)=C/[C@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H]2OC)C[C@H](OC(=O)/C=C/C(=O)O)[C@@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00003569_numbered.png,2026-03-19 06:58:44.159557
8559,ML00005623,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCCn2cnc(-c3ccccc3)c2)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005623_numbered.png,2026-03-19 06:58:44.212579
8560,ML00001099,CHEMBL3986081,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1cc(F)c(O[C@@H]3CCOC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8561,ML00010643,,,CC(C)C[C@@H]1OC(=O)CCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8562,ML00005710,,,C[C@H]1C(=O)N[C@H](C)C(=O)N2CCC[C@H]2C(=O)OC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)/C=C/C=C/C=C/C=C/C=C/C(=O)NC2=C(O)CCC2=O)C(=O)N2CCC[C@H]2C(=O)N1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8563,ML00003681,,,CC[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](CO[C@@H]2O[C@H](C)[C@@H](O)[C@@H](O)[C@H]2OC)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003681_numbered.png,2026-03-19 06:58:44.285874
8564,ML00009175,,,COC1C(OCC2C(C)OC(=O)/C=C\C(C)C(OC3OC(C)CC(O)C3O)CCC(C)(O)C(=O)/C=C\C3OC32)OC(C)C(O)C1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 10, 13, 14]",ring_size_16/standard/numbered/ML00009175_numbered.png,2026-03-19 06:58:44.333407
8565,ML00009948,,,CC1=C[C@@H]2[C@H](CC[C@H](C)[C@H]2O)[C@@]2(C)C(=O)O[C@H](C)CCC/C=C(/C(=O)O)[C@H](O)[C@@H](C)/C=C\C=C/[C@@H]12,standard_macrolactone,16.0,,,success,,5.0,"[3, 8, 9, 10, 16]",ring_size_16/standard/numbered/ML00009948_numbered.png,2026-03-19 06:58:44.370199
8566,ML00002660,,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@@H]4O[C@H]4/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002660_numbered.png,2026-03-19 06:58:44.420294
8567,ML00006550,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCNCCc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006550_numbered.png,2026-03-19 06:58:44.477157
8568,ML00002445,,,CCC(=O)O[C@H]1[C@H](OC)C[C@H](C)O[C@@H]1O[C@H]1[C@@H](C)/C=C\C(=O)O[C@@H](C)[C@@H](CO[C@@H]2O[C@H](C)[C@@H](OC(=O)CC)[C@@H](OC)[C@H]2OC)[C@H]2O[C@@H]2/C=C\C(=O)[C@](C)(O)C[C@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00002445_numbered.png,2026-03-19 06:58:44.531050
8569,ML00009423,,,CO/C1=C/C(C)=C\[C@@H](C)[C@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@@H](C)C(=O)C[C@H](OC(=O)/C=C/C(=O)O)[C@H](C)[C@H](C)O)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00009423_numbered.png,2026-03-19 06:58:44.583522
8570,ML00004801,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CCCCCCC2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00004801_numbered.png,2026-03-19 06:58:44.642992
8571,ML00003898,,,CCC(=O)OC1C(C)OC(OC2C(C)OC(OC3C(CC=O)CC(C)C(O)/C=C\C=C/CC(C)OC(=O)CC(OC(C)=O)C3OC)C(O)C2N(C)C)CC1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00003898_numbered.png,2026-03-19 06:58:44.690031
8572,ML00001326,CHEMBL102236,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3cccc(C)c3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8573,ML00000095,CHEMBL3898371,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(C3(C(=O)O)CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)ncc(F)c2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8574,ML00008231,,,C[C@H]1CC(=O)O[C@@H](C)[C@@H](O)/C=C\C(=O)O[C@@H](C)[C@H](O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8575,ML00002328,,,COC1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002328_numbered.png,2026-03-19 06:58:44.754206
8576,ML00007053,,,Cc1ccc(S(=O)(=O)NC2CCCCCCCCCCC(=O)OCCC2)cc1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00007053_numbered.png,2026-03-19 06:58:44.776928
8577,ML00001393,CHEMBL410881,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)C3(CCCCC3)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8578,ML00005617,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCCc2cnc3ccccc3c2)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00005617_numbered.png,2026-03-19 06:58:44.835663
8579,ML00007238,,,C/C1=C/[C@H](C)CC[C@H](C(Cl)(Cl)Cl)OC(=O)C[C@@H]([C@@H]2C[C@H]2Cl)OC(=O)/C=C\[C@@H]2[C@@H]1CC=C1C(=O)NC[C@@]12C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8580,ML00002031,CHEMBL3650145,,CC(=O)SCC/C=C/[C@@H]1CC(=O)N[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C(C)C)C(=O)NCC(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8581,ML00004419,,,CCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](C/C=C/c4cncc5ccccc45)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(=O)CC,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8582,ML00008981,,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/ML00008981_numbered.png,2026-03-19 06:58:44.905410
8583,ML00009248,,,COC(=O)/C=C1/C[C@H]2C[C@H]3CCC[C@@H](C[C@H](C)/C=C\[C@@H](C)[C@@H](/C=C/C=C\C=C(/C)CC(=O)OC)OC(=O)C[C@@H](C1)O2)O3,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8584,ML00001921,CHEMBL399425,,C[C@@]1(N)Cc2ccc(F)c(c2)CC[C@H](c2ccc(F)cc2)NC(=O)c2cc(cc(-c3cccc(F)c3C#N)c2)COC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8585,ML00004146,,,CNCC(=O)NCc1ccc([C@H](Cl)[C@H](O)[C@@H](C)[C@@H]2C/C=C/C(=O)N[C@H](Cc3ccc(OC)c(Cl)c3)C(=O)NCC(C)(C)C(=O)O[C@@H](CC(C)C)C(=O)O2)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8586,ML00008196,,,CC1C/C=C/C=C/CCCCC(O)C/C=C/C(=O)O1,standard_macrolactone,16.0,,,success,,2.0,"[3, 13]",ring_size_16/standard/numbered/ML00008196_numbered.png,2026-03-19 06:58:44.950677
8587,ML00009860,,,C/C=C/C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](C)NC(=O)[C@@H](C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8588,ML00000672,CHEMBL3410859,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](c3ccccc3[N+](=O)[O-])OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8589,ML00009862,,,C[C@@H]1NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)/C=C/C=C/CO)COC(=O)[C@@H]2C[C@@H](C)CN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8590,ML00004854,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](C/C=C/c4ccnc5ccccc45)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8591,ML00006803,,,CC1CCC(=NOC(=O)COc2ccc(Cl)cc2)CCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/ML00006803_numbered.png,2026-03-19 06:58:45.006391
8592,ML00008844,,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(C#Cc3ccccc3)OS(C)(=O)=O)OC(=O)[C@H](CC(C)C)OC(=O)[C@@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8593,ML00000375,CHEMBL2323288,,CC(C)[C@@H]1NC(=O)Cn2nnnc2-c2csc(n2)CNC(=O)C[C@@H](/C=C/CCS)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8594,ML00009082,,,CO[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@H](C)/C=C\C(=O)O[C@@H](C)[C@@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)[C@H]3O[C@H]3/C=C\C(=O)[C@](C)(O)C[C@H]2C)[C@@H]1O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 10, 12, 13, 14]",ring_size_16/standard/numbered/ML00009082_numbered.png,2026-03-19 06:58:45.067792
8595,ML00001667,CHEMBL42743,TYLOSIN,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00001667_numbered.png,2026-03-19 06:58:45.121482
8596,ML00007422,,,CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCSCc2cccs2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8597,ML00002335,,,C=CCO[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](O)CC(=O)O[C@H](CC)[C@@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)/C=C(C)/C=C/C(=O)[C@H](C)C[C@@H]2CC=O)[C@H](O)[C@H]1N(C)C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00002335_numbered.png,2026-03-19 06:58:45.181887
8598,ML00000634,CHEMBL3317813,,C[C@@]12CSC(=N1)c1csc(n1)CNC(=O)C[C@@H](/C=C/CCS)OC(=O)[C@H](CC(=O)O)NC2=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8599,ML00009623,,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@H](OC(C)=O)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00009623_numbered.png,2026-03-19 06:58:45.245580
8600,ML00006342,,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCCc2cccc3ccccc23)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/ML00006342_numbered.png,2026-03-19 06:58:45.310548
8601,ML00010138,,,O=C1CC(c2ccc(O)cc2)c2c(O)cc(O)c3c(=O)c(O)c(oc23)-c2cc(O)c(O)c(c2)OC2OC(CO1)C(O)C(O)C2O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8602,ML00006602,,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@H]2O[C@@H](O)C[C@H]2C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 6, 9, 10, 14, 15]",ring_size_16/standard/numbered/ML00006602_numbered.png,2026-03-19 06:58:45.368179
8603,ML00006824,,,CC(=O)CC(=O)NC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)C2=N[C@@](C)(CS2)C(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8604,ML00007693,,,C/C(=C\c1csc(CO)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/ML00007693_numbered.png,2026-03-19 06:58:45.429269
8605,ML00004818,,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@@H](C/C=C/c4cccc5ccccc45)CCCN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8606,ML00009054,,,CO[C@@H](/C(C)=C/C=C/C(C)=C\c1coc(C)n1)[C@@H](C)[C@@H]1C[C@H](O)[C@@]2(C)O[C@@H]2/C=C\[C@@H](C)[C@H](O)C[C@H](CC(=O)O)C/C=C\C(=O)O1,standard_macrolactone,16.0,,,success,,6.0,"[3, 5, 6, 10, 11, 13]",ring_size_16/standard/numbered/ML00009054_numbered.png,2026-03-19 06:58:45.487326
8607,ML00006807,,,Cc1cc(Cl)ccc1OCC(=O)O/N=C1/CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/ML00006807_numbered.png,2026-03-19 06:58:45.514983
8608,ML00008865,,,CCCCCCCC(=O)OCC/C=C/[C@H](Cl)[C@H](O)[C@@H]1OC(=O)/C=C\C=C/c2nc(oc2C)/C=C(/C)CC[C@H]2O[C@H]2[C@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8609,ML00007375,,,CC(C)C[C@@H]1NC(=O)OC(CCCc2ccccc2)CCCCCNC(=O)CC[C@@H](C(O)S(=O)(=O)O)NC1=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8610,ML00000626,CHEMBL4097169,,CC(C)C[C@@H]1NC(=O)OC(c2cccc(Cl)c2)CCCCCNC(=O)CC[C@@H](C=O)NC1=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8611,ML00004790,,,CCNC1CC2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C(CO)=C(/C)CCc4ccnc6c4CCC(NC)N6)C5=O)C(=O)OCC1CC23,standard_macrolactone,17.0,,,success,,3.0,"[12, 12, 16]",ring_size_17/standard/numbered/ML00004790_numbered.png,2026-03-19 06:58:45.573744
8612,ML00009109,,,O=C1O[C@@H]2[C@@H](COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c4oc(=O)c5c(ccc6oc(=O)c3c4c65)-c3c1cc(O)c(O)c3O)O[C@@H](O)[C@H](O)[C@H]2O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8613,ML00010673,,,CCCCCCCC(=O)OCC/C=C/[C@H]1O[C@H]1[C@H]1OC(=O)/C=C\C=C/C(=O)NC(=O)/C=C(/C)CC[C@@H]2O[C@@H]2[C@@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8614,ML00004778,,,COc1c(OC(C)C)cc2cc(O)c(C(=O)NC3Cc4ccc(c(Cl)n4)O[C@@H]4C=C5C#C/C(=C\C#CC6OC56C4OC4CC(C)(O)C(O)C(C)O4)C(OC4CC(O)C(N(C)C)C(C)O4)COC3=O)cc2c1OC,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8615,ML00004630,,,CCNC1C=C2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C(CO)=C(/C)CCc4ccnc6c4CCC(NC)N6)C5=O)C(=O)OC(CCCO)C1CC23,standard_macrolactone,17.0,,,success,,4.0,"[3, 12, 12, 16]",ring_size_17/standard/numbered/ML00004630_numbered.png,2026-03-19 06:58:45.633347
8616,ML00000658,CHEMBL3628304,,CC(C)[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)N[C@H](C(C)C)c1cn(nn1)CC(=O)O2,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8617,ML00009918,,,CCCCCCCC(=O)OCC/C=C/[C@@H](O)[C@@H](O)[C@H]1OC(=O)/C=C\C=C/[C@@](OC)(C(C)=O)NC(=O)/C=C(/C)CC[C@H]2O[C@@H]2[C@@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8618,ML00009190,,,C#CCCC[C@@H]1OC(=O)CCNC(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)C1(C)C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8619,ML00000620,CHEMBL2323285,,CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)-c2nnn(n2)CC(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8620,ML00009375,,,CCCC(=O)N[C@@H](CC(C)C)[C@@H](CC(=O)O[C@@H]1COC(=O)c2csc(n2)[C@H](C(C)C)OC(=O)[C@@H](C)[C@H](CCCC(C)(Cl)Cl)OC(=O)c2csc1n2)OC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8621,ML00004743,,,CS[C@H]1SC[C@H](N(C)C(=O)[C@H](C)NC(=O)[C@@H](CO)NC(=O)c2cnc3ccccc3n2)C(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@@H](NC(=O)c2cnc3ccccc3n2)C(=O)N[C@@H](C)C(=O)N(C)[C@@H]1C(=O)N(C)[C@H](C(=O)O)C(C)C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8622,ML00007390,,,CC[C@H]1/C=C\[C@@H](O)[C@@H](C)OC(=O)/C(C)=C\[C@H]2C(=O)NC3=CC(=O)c4c(cc(C)c(O)c4C(=O)CC1)[C@]32O,standard_macrolactone,17.0,,,success,,6.0,"[3, 4, 7, 10, 14, 17]",ring_size_17/standard/numbered/ML00007390_numbered.png,2026-03-19 06:58:45.720074
8623,ML00007389,,,CC[C@H]1/C=C\[C@@H](O)[C@@H](C)OC(=O)/C(C)=C\[C@@H]2C(=O)NC3=CC(=O)c4c(cc(C)c(O)c4C(=O)CC1)[C@]32O,standard_macrolactone,17.0,,,success,,6.0,"[3, 4, 7, 10, 14, 17]",ring_size_17/standard/numbered/ML00007389_numbered.png,2026-03-19 06:58:45.767812
8624,ML00009023,,,C/C=C(C)/C=C(\C)C(O)C(C)[C@H](O)[C@@H](O)[C@H]1C/C=C\C=C\[C@H](O)C[C@@H](O)[C@H](C)c2nc(cs2)/C=C(\CCCCCC)C(=O)O1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8625,ML00000399,CHEMBL2323289,,CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)-c2cn(nn2)CC(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8626,ML00004784,,,CCNC1C=C2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C(CO)=C(/C)CCc4ccnc6c4CCC(NC)N6)C5=O)C(=O)OCC1CC23,standard_macrolactone,17.0,,,success,,3.0,"[12, 12, 16]",ring_size_17/standard/numbered/ML00004784_numbered.png,2026-03-19 06:58:45.822894
8627,ML00010734,,,CC[C@H]1OC(=O)CC[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)N(C)CCC/C(C)=C/[C@@H]1CO,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8628,ML00007345,,,C[C@H](O)[C@@]12/C=C\C=C/C(=O)O[C@@H]3C[C@H]4O[C@@H]5CCC[C@@H](COC(=O)[C@H]6O[C@@]6(CCO1)[C@@H]2O)[C@@H]5[C@]3(C)[C@]41CO1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8629,ML00005969,,,CCNC1C=C2C=CCC3CCCCC(C)Cc4cccc5c4C(=O)C4(OC4(C/C(CO)=C(/C)CCc4ccnc(NCNC)c4)C5=O)C(=O)OCC1CC23,standard_macrolactone,17.0,,,success,,2.0,"[12, 16]",ring_size_17/standard/numbered/ML00005969_numbered.png,2026-03-19 06:58:45.873911
8630,ML00008864,,,CCCCCCCC(=O)OCC/C=C/[C@H](Cl)[C@H](O)[C@@H]1OC(=O)/C=C\C=C/C(=O)N(C(C)=O)C(=O)/C=C(/C)CC[C@H]2O[C@H]2[C@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8631,ML00004391,,,CC(C)SC1SCC2C(=O)N(C)C3(CC3C)C(=O)OCC(NC(=O)c3nc4ccccc4cc3O)C(=O)NC(C)C(=O)N(C)C1C(=O)N(C)C1(CC1C)C(=O)OCC(NC(=O)c1nc3ccccc3cc1O)C(=O)NC(C)C(=O)N2C,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8632,ML00005681,,,C[C@H](O)CCC/C=C/C=C/C(=O)CCCCCCCC(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H]1C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CO)C(=O)NCC(=O)O[C@H]1C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8633,ML00004774,,,CSC1[C@H]2C(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@H](NC(=O)c3cnc4ccccc4n3)C(=O)N[C@@H](C)C(=O)N(C)[C@@H](C[S+]1C)C(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@H](NC(=O)c1cnc3ccccc3n1)C(=O)N[C@@H](C)C(=O)N2C,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8634,ML00008352,,,C[C@@]12CSC(=N1)c1csc(n1)CNC(=O)C[C@@H](/C=C/CCS)OC(=O)CCNC2=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8635,ML00010176,,,CC(C)[C@@H]1OC(=O)C[C@@H](c2ccccc2)OC(=O)C[C@@H](c2ccccc2)OC(=O)[C@H](C)NC(=O)[C@H](C)N(C)C1=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8636,ML00001622,CHEMBL3577069,,CCCCCCCCCCCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc2ccccc2)C(=O)O[C@@H]1C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8637,ML00004777,,,CCNC1C=C2C=CCC3C4CCCC(C)(Cc5ccc(N)nc5)Cc5cccc6c5C(=O)C5(OC5(C/C(CO)=C(/C)CCc5ccnc(NCNC)c5)C6=O)C(=O)OCC1C(CC4)C23,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8638,ML00005614,,,CCCCC/C=C/C=C/[C@H](O)CCCCCCCC(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H]1C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CO)C(=O)NCC(=O)O[C@@H]1C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8639,ML00008018,,,O=C1CCCCCCCCCCOCCCCO1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8640,ML00010658,,,CCCCCCCC(=O)OCC/C=C\[C@H]1O[C@H]1[C@H]1OC(=O)/C=C\C=C/C(=O)NC(=O)/C=C(/C)CC[C@H]2O[C@H]2[C@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8641,ML00001028,CHEMBL3092469,,CC[C@@H]1/C=C/[C@H](O)[C@H](C)OC(=O)/C(C)=C\[C@H]2C(=O)NC3=CC(=O)c4c(cc(C)c(O)c4C(=O)CC1)[C@@]32O,standard_macrolactone,17.0,,,success,,6.0,"[3, 4, 7, 10, 14, 17]",ring_size_17/standard/numbered/ML00001028_numbered.png,2026-03-19 06:58:46.015896
8642,ML00008858,,,CCCCCCCC(=O)OCC/C=C\[C@H](O)[C@H](O)[C@H]1OC(=O)/C=C\C=C/C(=O)N(C(C)=O)C(=O)/C=C(/C)CC[C@H]2O[C@@H]2[C@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8643,ML00006448,,,O=C1OC(C2OC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c4oc(=O)c5c(c(O)c(O)c6oc(=O)c3c4c65)-c3c(cc(O)c(O)c3O)C(=O)OCC2O)C2OC(=O)c3c(c(O)c(O)c(O)c3[C@H]2O)-c2c1cc(O)c(O)c2O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8644,ML00004631,,,CCNC1C=C2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C(CO)=C(/C)CC4(c6ccnc(NCNC)c6)CCCCC4)C5=O)C(=O)OCC1CC23,standard_macrolactone,17.0,,,success,,3.0,"[12, 12, 16]",ring_size_17/standard/numbered/ML00004631_numbered.png,2026-03-19 06:58:46.066676
8645,ML00000927,CHEMBL263730,,CSC1SCC2C(=O)N(C)C(C(C)C)C(=O)OCC(NC(=O)c3cnc4ccccc4n3)C(=O)NC(C)C(=O)N(C)C1C(=O)N(C)C(C(C)C)C(=O)OCC(NC(=O)c1cnc3ccccc3n1)C(=O)NC(C)C(=O)N2C,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8646,ML00008129,,,O=C1CCCCCCC/C=C/CCCCCCO1,standard_macrolactone,17.0,,,success,,0.0,[],ring_size_17/standard/numbered/ML00008129_numbered.png,2026-03-19 06:58:46.093514
8647,ML00005238,,,CCNC1C=C2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C=C(/C)C4(C6(c7ccnc(NCNC)c7)CCCN=C(NC)N6)CCCC4)C5=O)C(=O)OCC1CC23,standard_macrolactone,17.0,,,success,,3.0,"[12, 12, 16]",ring_size_17/standard/numbered/ML00005238_numbered.png,2026-03-19 06:58:46.127890
8648,ML00000249,CHEMBL385359,,CN1C2CCC1C1COC(=O)CCCCCCC(=O)Nc3ccc(cc3)C1C2,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8649,ML00004765,,,CC(C)[C@H]1C(=O)OC[C@H](NC(=O)c2cnc3ccccc3n2)C(=O)N[C@@H](C)C(=O)N(C)[C@@H]2C(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@H](NC(=O)c3cnc4ccccc4n3)C(=O)N[C@@H](C)C(=O)N(C)[C@@H](CSC2[S+](C)[O-])C(=O)N1C,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8650,ML00008857,,,CCCCCCCC(=O)OCC/C=C/[C@H](O)[C@H](O)[C@H]1OC(=O)/C=C\C=C/C(=O)N(C(C)=O)C(=O)/C=C(/C)CC[C@H]2O[C@@H]2[C@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8651,ML00006463,,,O=CC1OC(=O)c2cc(O)c(O)c(O)c2-c2c(cc(O)c(O)c2O)C(=O)OC1C1OC(=O)c2cc(O)c(O)c(O)c2-c2c(O)c(O)c3oc(=O)c4c(c(O)c(O)c5oc(=O)c2c3c54)-c2c(cc(O)c(O)c2O)C(=O)OCC1O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8652,ML00009897,,,C/C=C(C)/C=C(\C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](O)[C@H]1C/C=C(C)\C=C/[C@@H](O)C[C@H](O)[C@@H](C)c2nc(cs2)/C=C(/CCCCCC)C(=O)O1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8653,ML00008130,,,O=C1CCCCC/C=C/CCCCCCCCO1,standard_macrolactone,17.0,,,success,,0.0,[],ring_size_17/standard/numbered/ML00008130_numbered.png,2026-03-19 06:58:46.186245
8654,ML00009868,,,CCCCCCCC(=O)OCC/C=C/[C@@H]1O[C@@H]1[C@@H]1OC(=O)/C=C\C=C/[C@@](OC)(C(C)=O)NC(=O)/C=C(/C)CC[C@H]2O[C@H]2[C@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8655,ML00000611,CHEMBL3628321,,CC(=O)SCC/C=C/[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H](C(C)C)c2cn(nn2)CC(=O)O1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8656,ML00001918,CHEMBL502440,PUNICALIN,O=C1OC[C@H]2O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]2OC(=O)c2cc(O)c(O)c(O)c2-c2c(O)c(O)c3oc(=O)c4c(c(O)c(O)c5oc(=O)c2c3c54)-c2c1cc(O)c(O)c2O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8657,ML00009376,,,CCCC(=O)N[C@@H](CC(C)C)[C@@H](CC(=O)O[C@@H]1COC(=O)c2csc(n2)[C@H](C(C)(C)O)OC(=O)[C@@H](C)[C@H](CCCC(C)(Cl)Cl)OC(=O)c2csc1n2)OC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8658,ML00004038,,,O=C(O[C@H]1[C@@H](O)O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c4oc(=O)c5c(c(O)c(O)c6oc(=O)c3c4c65)-c3c(cc(O)c(O)c3O)C(=O)O[C@H]2[C@@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8659,ML00004767,,,CS[C@H]1SC[C@H]2C(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@@H](NC(=O)c3cnc4ccccc4n3)C(=O)N[C@@H](C)C(=O)N(C)[C@@H]1C(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@@H](NC(=O)c1cnc3ccccc3n1)C(=O)N[C@@H](C)C(=O)N2C,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8660,ML00008855,,,CCCCCCCC(=O)OCC[C@@H](O)/C=C/[C@H](O)[C@@H]1OC(=O)/C=C\C=C/C(=O)N(C(C)=O)C(=O)/C=C(/C)CC[C@H]2O[C@H]2[C@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8661,ML00005297,,,CCNC1C=C2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C=C(/C)CC4(c6ccnc(NCNC)c6)CCCN=C(NC)N4)C5=O)C(=O)OC(CCCO)C1CC23,standard_macrolactone,17.0,,,success,,4.0,"[3, 12, 12, 16]",ring_size_17/standard/numbered/ML00005297_numbered.png,2026-03-19 06:58:46.269701
8662,ML00008017,,,O=C1CCCCCCCCCOCCCCCO1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8663,ML00008131,,,O=C1CCCCC/C=C\CCCCCCCCO1,standard_macrolactone,17.0,,,success,,0.0,[],ring_size_17/standard/numbered/ML00008131_numbered.png,2026-03-19 06:58:46.292801
8664,ML00001488,CHEMBL492595,,CS[C@@H]1[C@H]2C(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@@H](NC(=O)c3cnc4ccccc4n3)C(=O)N[C@@H](C)C(=O)N(C)[C@@H](C[S+]1[O-])C(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@@H](NC(=O)c1cnc3ccccc3n1)C(=O)N[C@@H](C)C(=O)N2C,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8665,ML00008797,,,CC[C@@H]1OC(=O)CCCCCCC/C=C\C/C=C\C[C@@H]1O,standard_macrolactone,17.0,,,success,,2.0,"[3, 4]",ring_size_17/standard/numbered/ML00008797_numbered.png,2026-03-19 06:58:46.325396
8666,ML00009919,,,CCCCCCCC(=O)OCC/C=C/[C@H](O)[C@H](O)[C@H]1OC(=O)/C=C\C=C/[C@@](OC)(C(C)=O)NC(=O)/C=C(/C)CC[C@H]2O[C@@H]2[C@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8667,ML00004532,,,CCNC1C=C2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C=C(/C)CC4(c6ccnc7c6CCC(NC)N7)CCCN=C(NC)N4)C5=O)C(=O)OCC1CC23,standard_macrolactone,17.0,,,success,,3.0,"[12, 12, 16]",ring_size_17/standard/numbered/ML00004532_numbered.png,2026-03-19 06:58:46.363888
8668,ML00009869,,,CCCCCCCC(=O)OCC/C=C/[C@H]1O[C@@H]1[C@H]1OC(=O)/C=C\C=C/[C@@](OC)(C(C)=O)NC(=O)/C=C(/C)CC[C@H]2O[C@@H]2[C@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8669,ML00004034,,,O=C(O[C@H]1[C@@H](O)O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c4oc(=O)c5c(c(O)c(O)c6oc(=O)c3c4c65)-c3c(cc(O)c(O)c3O)C(=O)O[C@H]2[C@@H]1O)c1ccc(O)c(O)c1O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8670,ML00001695,CHEMBL3628309,,CC(C)[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)Nc1ccccc1C(=O)NCC(=O)O2,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8671,ML00006462,,,O=C1O[C@H]([C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c4oc(=O)c5c(c(O)c(O)c6oc(=O)c3c4c65)-c3c(cc(O)c(O)c3O)C(=O)OC[C@H]2O)[C@@H]2OC(=O)c3c(c(O)c(O)c(O)c3[C@H]2O)-c2c1cc(O)c(O)c2O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8672,ML00009246,,,C#CCCC[C@H]1OC(=O)CCNC(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H]([C@H](C)CC)NC(=O)C1(C)C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8673,ML00004037,,,O=C(O[C@H]1C(O)O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c4oc(=O)c5c(c(O)c(O)c6oc(=O)c3c4c65)-c3c(cc(O)c(O)c3O)C(=O)O[C@H]2[C@@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8674,ML00010763,,,CCCCCCCCCCC[C@@H]1CCCCCCCCCC(=O)OC[C@H]2O[C@@H](O1)[C@H](O)[C@@H](OC(C)=O)[C@@H]2O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8675,ML00006645,,,CCCCCC1CCCCCNC(=O)CC[C@@H](C(O)S(=O)(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)O1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8676,ML00001037,CHEMBL4071015,,CC(C)C[C@@H]1NC(=O)OC(CCCc2ccccc2)CCCCCNC(=O)CC[C@@H](C=O)NC1=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8677,ML00009029,,,CC[C@H](C)C[C@H](C)[C@H]1OC(=O)[C@H](Cc2ccccc2)NC(=O)/C(C)=C\[C@H](C)[C@@H](O)/C(C)=C\[C@H](C)[C@H](O)/C(C)=C\[C@@H]1C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8678,ML00009032,,,C/C=C(C)/C=C(\C)[C@H](O)[C@@H](C)[C@@H](O)[C@H](O)[C@@H]1C/C=C\C=C/[C@@H](O)C[C@H](O)[C@@H](C)c2nc(cs2)/C=C(/CCCCCC)C(=O)O1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8679,ML00010618,,,CCC[C@@H](CC[C@@H](C)[C@@H]1OC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)CCO)N(C)C(=O)[C@]2(C)CN(O2)C(=O)[C@H](C)NC(=O)C1(C)C)OC,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8680,ML00000130,CHEMBL3628322,,CC(=O)SCC/C=C/[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C(C)C)c2cn(nn2)CC(=O)O1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8681,ML00004423,,,CSC1SCC2C(=O)N(C)C(C(C)C(C)C)C(=O)OCC(NC(=O)c3cnc4ccccc4n3)C(=O)NC(C)C(=O)N(C)C1C(=O)N(C)C(C(C)C(C)C)C(=O)OCC(NC(=O)c1cnc3ccccc3n1)C(=O)NC(C)C(=O)N2C,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8682,ML00006663,,,CC(C)[C@@H]1OC(=O)[C@@H](C)[C@H](CCC[C@H](C)Cl)OC(=O)c2csc(n2)[C@H](O)COC(=O)c2csc1n2,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8683,ML00008876,,,CCCCCCCC(=O)OCC/C=C/[C@H]1O[C@@H]1[C@@H]1OC(=O)/C=C\C=C/c2nc(oc2C)/C=C(/C)CC[C@@H]2O[C@H]2[C@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8684,ML00009261,,,O=C1OC[C@@H]2O[C@@H](O)[C@@H](O)[C@H](O)[C@@H]2OC(=O)[C@@H]2[CH][C@@H](O)[C@@H](O)[C@@H](O)[C@@H]2[C@@H]2[C@H](O)[C@H](O)[C@@H]3OC(=O)[C@@H]4[C@@H]([C@H](O)[C@H](O)[C@@H]5OC(=O)[C@H]2[C@H]3[C@@H]54)[C@@H]2[C@H](O)[C@H](O)[C@@H](O)[CH][C@@H]12,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8685,ML00002118,CHEMBL500610,,C=CCNC(=O)C(=O)[C@@H]1CCCCNC(=O)OCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N2C[C@H]3[C@@H]([C@H]2C(=O)N1)C3(C)C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8686,ML00010674,,,CCCCCCCC(=O)OCC/C=C/[C@H]1O[C@@H]1[C@@H]1OC(=O)/C=C\C=C/C(=O)NC(=O)/C=C(/C)CC[C@@H]2O[C@H]2[C@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8687,ML00001001,CHEMBL4092885,,CC(C)C[C@@H]1NC(=O)OC(Cc2ccccc2)CC/C=C/CNC(=O)CC[C@@H](C=O)NC1=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8688,ML00008227,,,O=C1CCCCC/C=C\C/C=C\C/C=C\CCO1,standard_macrolactone,17.0,,,success,,0.0,[],ring_size_17/standard/numbered/ML00008227_numbered.png,2026-03-19 06:58:46.518919
8689,ML00005720,,,CCCCC/C=C/C=C/C(=O)CCCCCCCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CO)C(=O)NCC(=O)O[C@@H]1C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8690,ML00001797,CHEMBL361050,,O=C1CCCCCCCCCC/C=C2/CC(CO)(CO1)OC2=O,standard_macrolactone,17.0,,,success,,1.0,[4],ring_size_17/standard/numbered/ML00001797_numbered.png,2026-03-19 06:58:46.551256
8691,ML00000595,CHEMBL505302,HECTOCHLORIN,CC(=O)O[C@@H]1c2nc(cs2)C(=O)O[C@@H](CCCC(C)(Cl)Cl)[C@H](C)C(=O)O[C@@H](C(C)(C)O)c2nc(cs2)C(=O)OC1(C)C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8692,ML00008132,,,O=C1CCCC/C=C/CCCCCCCCCO1,standard_macrolactone,17.0,,,success,,0.0,[],ring_size_17/standard/numbered/ML00008132_numbered.png,2026-03-19 06:58:46.576225
8693,ML00009189,,,C#CCCCC1OC(=O)CCNC(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)C1(C)C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8694,ML00000372,CHEMBL2323290,,CC(C)[C@@H]1NC(=O)Cn2cc(nn2)-c2csc(n2)CNC(=O)C[C@@H](/C=C/CCS)OC1=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8695,ML00001183,CHEMBL3628747,,CC(=O)SCC/C=C/[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(C)C)c2cn(nn2)CC(=O)O1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8696,ML00006853,,,CC(C)C[C@@H]1NC(=O)OC(c2cccc(Cl)c2)CCCCCNC(=O)CC[C@@H](C(O)S(=O)(=O)O)NC1=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8697,ML00000179,CHEMBL4065146,,O=C[C@@H]1CCC(=O)NCCCCCC(c2cccc(Cl)c2)OC(=O)N[C@@H](CC2CCCCC2)C(=O)N1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8698,ML00001776,CHEMBL486608,DEACETYLHECTOCHLORIN,C[C@@H]1C(=O)O[C@@H](C(C)(C)O)c2nc(cs2)C(=O)OC(C)(C)[C@H](O)c2nc(cs2)C(=O)O[C@H]1CCCC(C)(Cl)Cl,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8699,ML00010998,,,CC[C@@H]1/C=C\[C@@H]([C@@H](O)C=C(C)C)OC(=O)/C(C)=C\CC(=O)Nc2cc(O)cc3c2O[C@@]2(CC1)CC(=O)[C@@H](C)[C@@H]3O2,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8700,ML00008872,,,CCCCCCCC(=O)OCC/C=C/[C@@H]1O[C@@H]1[C@@H]1OC(=O)/C=C\C=C/C(=O)N(C(C)=O)C(=O)/C=C(/C)CC[C@H]2O[C@H]2[C@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8701,ML00006465,,,O=C1O[C@@H]2[C@@H](O)O[C@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(O)c(O)c5oc(=O)c6c(c(O)c(O)c7oc(=O)c4c5c76)-c4c(cc(O)c(O)c4O)C(=O)O[C@H]3[C@H]2OC(=O)c2cc(O)c(O)c(O)c2-c2c1cc(O)c(O)c2O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8702,ML00008871,,,CCCCCCCC(=O)OCC/C=C/[C@H]1O[C@H]1[C@H]1OC(=O)/C=C\C=C/C(=O)N(C(C)=O)C(=O)/C=C(/C)CC[C@@H]2O[C@H]2[C@@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8703,ML00000592,CHEMBL3771206,,CC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2ccc(cc2)C2=N[C@@](C)(CS2)C(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8704,ML00004758,,,CCNC1C=C2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C(CO)=C(/C)CCc4ccnc(NCNC)c4)C5=O)C(=O)OCC1CC23,standard_macrolactone,17.0,,,success,,3.0,"[12, 12, 16]",ring_size_17/standard/numbered/ML00004758_numbered.png,2026-03-19 06:58:46.677038
8705,ML00006632,,,CC[C@@](C)(O)[C@H]1OC(=O)[C@@H](C)[C@@H](CCCC(C)(Cl)Cl)OC(=O)c2csc(n2)[C@H](O)COC(=O)c2csc1n2,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8706,ML00008873,,,CCCCCCCC(=O)OCC/C=C/[C@H]1O[C@@H]1[C@@H]1OC(=O)/C=C\C=C/C(=O)N(C(C)=O)C(=O)/C=C(/C)CC[C@@H]2O[C@H]2[C@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8707,ML00000029,CHEMBL416615,,O=C1OCC2OC(O)C(O)C(O)C2OC(=O)c2cc(O)c(O)c(O)c2-c2c(O)c(O)c3oc(=O)c4c(c(O)c(O)c5oc(=O)c2c3c54)-c2c1cc(O)c(O)c2O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8708,ML00010239,,,CC[C@H]1/C=C\[C@H](C)[C@H](C)OC(=O)/C(C)=C\[C@@H]2C(=O)NC3=CC(=O)c4c(cc(C)c(O)c4C(=O)CC1)[C@@]32O,standard_macrolactone,17.0,,,success,,6.0,"[3, 4, 7, 10, 14, 17]",ring_size_17/standard/numbered/ML00010239_numbered.png,2026-03-19 06:58:46.736515
8709,ML00010442,,,CC1=CC2OC3CC4OC(=O)/C=C/C=C/C56OC/C(=C/C(=O)OCC2(CC1)C4(C)C31CO1)CC5OC(O)C6O,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8710,ML00004779,,,CSC1SCC2C(=O)N(C)C3(CC3C)C(=O)OCC(NC(=O)c3nc4ccccc4cc3O)C(=O)NC(C)C(=O)N(C)C1C(=O)N(C)C1(CC1C)C(=O)OCC(NC(=O)c1nc3ccccc3cc1O)C(=O)NC(C)C(=O)N2C,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8711,ML00007212,,,O=C1CC[C@@H](C(O)S(=O)(=O)O)NC(=O)C2(CCCCC2)NC(=O)OC(c2cccc(Cl)c2)CCCCCN1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8712,ML00004763,,,CC(C)[C@H]1C(=O)OC[C@H](NC(=O)c2cnc3ccccc3n2)C(=O)N[C@@H](C)C(=O)N(C)[C@@H]2C(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@H](NC(=O)c3cnc4ccccc4n3)C(=O)N[C@@H](C)C(=O)N(C)[C@@H](CSC2S(C)(=O)=O)C(=O)N1C,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8713,ML00004120,,,CC(=O)O[C@H](CC(=O)O[C@@H]1COC(=O)c2csc(n2)[C@H](C(C)C)OC(=O)[C@@H](C)[C@H](CCCC(C)(Cl)Cl)OC(=O)c2csc1n2)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)N(C)C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8714,ML00008179,,,O=C1CCCCCCCCCCCCCCCO1,standard_macrolactone,17.0,,,success,,0.0,[],ring_size_17/standard/numbered/ML00008179_numbered.png,2026-03-19 06:58:46.791735
8715,ML00001464,CHEMBL407558,,O=C1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c4oc(=O)c5c(c(O)c(O)c6oc(=O)c3c4c65)-c3c(cc(O)c(O)c3O)C(=O)OC2C2OC(=O)c3c(c(O)c(O)c(O)c3-c3c(O)c(O)c(O)c4c3C(=O)OC2[C@@H]4O)-c2c1cc(O)c(O)c2O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8716,ML00004036,,,O=C(O[C@H]1[C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c4oc(=O)c5c(c(O)c(O)c6oc(=O)c3c4c65)-c3c(cc(O)c(O)c3O)C(=O)OC[C@@H]2O[C@@H](O)[C@@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8717,ML00007872,,,CC[C@H]1C#CC#C[C@@H](O)[C@@H]2O[C@@H]2CCCCCCCC(=O)O1,standard_macrolactone,17.0,,,success,,2.0,"[3, 8]",ring_size_17/standard/numbered/ML00007872_numbered.png,2026-03-19 06:58:46.833797
8718,ML00010473,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\CC[C@@]56OCC/C(=C\C(=O)OC[C@H](C1)[C@@H]2[C@]4(C)[C@@]31CO1)[C@@H]5O[C@@H](O)[C@H]6O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8719,ML00009107,,,O=C1OC[C@@H]2O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]2OC(=O)c2cc(O)c(O)c(O)c2-c2c(O)c(O)c3oc(=O)c4c(c(O)c(O)c5oc(=O)c2c3c54)-c2c1cc(O)c(O)c2O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8720,ML00001029,CHEMBL3092470,,CC[C@@H]1/C=C/[C@H](O)[C@H](C)OC(=O)/C(C)=C\[C@@H]2C(=O)NC3=CC(=O)c4c(cc(C)c(O)c4C(=O)CC1)[C@@]32O,standard_macrolactone,17.0,,,success,,6.0,"[3, 4, 7, 10, 14, 17]",ring_size_17/standard/numbered/ML00001029_numbered.png,2026-03-19 06:58:46.887357
8721,ML00001006,CHEMBL4081590,,CC(C)C[C@@H]1NC(=O)OC(c2ccccc2)CCCCCNC(=O)CC[C@@H](C=O)NC1=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8722,ML00009030,,,C/C=C(C)/C=C(\C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]1C/C=C\C=C/[C@@H](O)C[C@H](O)[C@H](C)c2nc(cs2)/C=C(/CCCCCC)C(=O)O1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8723,ML00008875,,,CCCCCCCC(=O)OCC/C=C/[C@@H]1O[C@@H]1[C@@H]1OC(=O)/C=C\C=C/c2nc(oc2C)/C=C(/C)CC[C@H]2O[C@H]2[C@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8724,ML00005449,,,CCNC1C=C2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C=C(/C)C4(C6(c7ccnc8c7CCC(NC)N8)CCCN=C(NC)N6)CCCC4)C5=O)C(=O)OCC1CC23,standard_macrolactone,17.0,,,success,,3.0,"[12, 12, 16]",ring_size_17/standard/numbered/ML00005449_numbered.png,2026-03-19 06:58:46.940404
8725,ML00006771,,,O=C[C@@H]1CCC(=O)NCCCCCC(c2cccc(Cl)c2)OC(=O)NC2(CCCCC2)C(=O)N1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8726,ML00005406,,,CNCNc1cc(C2(C/C(C)=C/CC34OC35C(=O)OCC3CC6C(=CC3NCC3CCCCC3)C=CCC6CCCCC(C)(Cc3ccc(N)nc3)Cc3cccc(c3C5=O)C4=O)CCCN=C(NC)N2)ccn1,standard_macrolactone,17.0,,,success,,3.0,"[12, 12, 16]",ring_size_17/standard/numbered/ML00005406_numbered.png,2026-03-19 06:58:46.980032
8727,ML00005628,,,CCCCC/C=C/C=C/[C@H](O)CCCCCCCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CO)C(=O)NCC(=O)O[C@@H]1C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8728,ML00004035,,,O=C(O[C@@H]1[C@@H](O)[C@H](O)O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c4oc(=O)c5c(c(O)c(O)c6oc(=O)c3c4c65)-c3c(cc(O)c(O)c3O)C(=O)O[C@H]21)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8729,ML00004757,,,CCNC1CC2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C(CO)=C(/C)CCc4ccnc(NCNC)c4)C5=O)C(=O)OCC1CC23,standard_macrolactone,17.0,,,success,,3.0,"[12, 12, 16]",ring_size_17/standard/numbered/ML00004757_numbered.png,2026-03-19 06:58:47.028424
8730,ML00008032,,,O=C1CCCCCCCCCCCC(=O)OCCO1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8731,ML00005682,,,C[C@H](O)CCC/C=C/C=C/C(=O)CCCCCCCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CO)C(=O)NCC(=O)O[C@@H]1C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8732,ML00005279,,,CNC1CCc2c(CC/C(C)=C(/CO)CC34OC35C(=O)OCC3CC6C(=CC3NCC3CCCCC3)C=CCC6CCCCC(C)(Cc3ccc(N)nc3)Cc3cccc(c3C5=O)C4=O)ccnc2N1,standard_macrolactone,17.0,,,success,,3.0,"[12, 12, 16]",ring_size_17/standard/numbered/ML00005279_numbered.png,2026-03-19 06:58:47.072512
8733,ML00010762,,,CCCCCCCCCCC[C@@H]1CCCCCCCCCC(=O)OC[C@H]2O[C@@H](O1)[C@H](OC(C)=O)[C@@H](O)[C@@H]2O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8734,ML00009867,,,CCCCCCCC(=O)OCC/C=C/[C@H]1O[C@@H]1[C@@H]1OC(=O)/C=C\C=C/[C@@](OC)(C(C)=O)NC(=O)/C=C(/C)CC[C@@H]2O[C@H]2[C@@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8735,ML00004424,,,CCNC1C=C2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C=C(/C)CC4(c6ccnc(NCNC)c6)CCCN=C(NC)N4)C5=O)C(=O)OCC1CC23,standard_macrolactone,17.0,,,success,,3.0,"[12, 12, 16]",ring_size_17/standard/numbered/ML00004424_numbered.png,2026-03-19 06:58:47.117539
8736,ML00006313,,,CSC[C@H]1C(=O)OC[C@@H](NC(=O)c2nc3ccccc3cc2O)C(=O)NCC(=O)N(C)[C@H]2CSS[C@@H](C(=O)N1C)N(C)C(=O)CNC(=O)[C@H](NC(=O)c1nc3ccccc3cc1O)COC(=O)[C@H](CSC)N(C)C2=O,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8737,ML00009092,,,O=CC(O)C(O)C1OC(=O)c2cc(O)c(O)c(O)c2C2=C(O)C(O)=C3OC(=O)c4c(c(O)c(O)c5c4C3C2C(=O)O5)-c2c(cc(O)c(O)c2O)C(=O)OCC1O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8738,ML00004039,,,O=CC(OC(=O)c1cc(O)c(O)c(O)c1)C(O)C1OC(=O)c2cc(O)c(O)c(O)c2-c2c(O)c(O)c3oc(=O)c4c(c(O)c(O)c5oc(=O)c2c3c54)-c2c(cc(O)c(O)c2O)C(=O)OCC1O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8739,ML00010177,,,CC(C)[C@H]1OC(=O)C[C@@H](c2ccccc2)OC(=O)C[C@@H](c2ccccc2)OC(=O)[C@H](C)NC(=O)[C@H](C)N(C)C1=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8740,ML00000174,CHEMBL3628323,,CC(=O)SCC/C=C/[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N[C@H](Cc2cn(C)cn2)C(=O)N[C@H](C(C)C)c2cn(nn2)CC(=O)O1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8741,ML00006671,,,C[C@@H]1C(=O)O[C@@H](C(C)(C)O)c2nc(cs2)C(=O)OC[C@@H](O)c2nc(cs2)C(=O)O[C@H]1CCCC(C)(Cl)Cl,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8742,ML00004628,,,CCNC1CC2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C(CO)=C(/C)CC4(c6ccnc(NCNC)c6)CCCCC4)C5=O)C(=O)OCC1CC23,standard_macrolactone,17.0,,,success,,3.0,"[12, 12, 16]",ring_size_17/standard/numbered/ML00004628_numbered.png,2026-03-19 06:58:47.190143
8743,ML00008848,,,CCCCCCCC(=O)OCC/C=C\[C@H](O)[C@H](O)[C@@H]1OC(=O)/C=C\C=C/c2nc(oc2C)/C=C(/C)CC[C@@H]2O[C@H]2[C@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8744,ML00010263,,,CCCCCCCCCCC[C@@H]1CCCCCCCCCC(=O)OC[C@H]2O[C@@H](O1)[C@H](O)[C@@H](O)[C@@H]2O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8745,ML00009108,,,O=CC(O)C(O)C1OC(=O)c2cc(O)c(O)c(O)c2-c2c(O)c(O)c3oc(=O)c4c(c(O)c(O)c5oc(=O)c2c3c54)-c2c(cc(O)c(O)c2O)C(=O)OCC1O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8746,ML00010489,,,CC(C)[C@@H]1NC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)OC(=O)C[C@@H](c2ccccc2)OC(=O)C[C@@H](c2ccccc2)OC1=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8747,ML00004483,,,CCNC1C=C2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C(CO)=C(/C)CCc4ccnc(NCNC)c4)C5=O)C(=O)OC(CCCO)C1CC23,standard_macrolactone,17.0,,,success,,4.0,"[3, 12, 12, 16]",ring_size_17/standard/numbered/ML00004483_numbered.png,2026-03-19 06:58:47.251160
8748,ML00005447,,,CNC1CCc2c(CC/C(C)=C(/CO)CC34OC35C(=O)OC(CCCO)C3CC6C(=CC3NCC3CCCCC3)C=CCC6CCCCC(C)(Cc3ccc(N)nc3)Cc3cccc(c3C5=O)C4=O)ccnc2N1,standard_macrolactone,17.0,,,success,,4.0,"[3, 12, 12, 16]",ring_size_17/standard/numbered/ML00005447_numbered.png,2026-03-19 06:58:47.285691
8749,ML00001888,CHEMBL364849,,O=C1CCCCCCCCCC/C=C2\CC(CO)(CO1)CC2=O,standard_macrolactone,17.0,,,success,,1.0,[4],ring_size_17/standard/numbered/ML00001888_numbered.png,2026-03-19 06:58:47.308181
8750,ML00000373,CHEMBL1551021,,C[C@@H]1/C=C\CC(=O)OC[C@H]2O[C@@H](C=C[C@@H]2O)[C@H](C)/C=C\CC(=O)OC1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8751,ML00006979,,,C[C@@H]1NC(=O)OC(c2cccc(Cl)c2)CCCCCNC(=O)CC[C@@H](C=O)NC1=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8752,ML00005721,,,CCCCC/C=C/C=C/C(=O)CCCCCCCC(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H]1C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CO)C(=O)NCC(=O)O[C@H]1C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8753,ML00005615,,,CCCCC/C=C/C=C/[C@H](O)CCCCCCCC(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H]1C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CO)C(=O)NCC(=O)O[C@H]1C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8754,ML00010123,,,C/C=C(C)/C=C(\C)C[C@H](C)[C@@H](O)[C@H](O)[C@@H]1C/C=C\C=C/[C@@H](O)C[C@H](O)[C@@H](CO)c2nc(cs2)/C=C(/C)C(=O)O1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8755,ML00010341,,,CC[C@@H]1/C=C\[C@H](C)[C@H](C)OC(=O)/C(C)=C\[C@@H]2C(=O)NC3=CC(=O)c4c(cc(C)c(O)c4C(=O)CC1)[C@]32O,standard_macrolactone,17.0,,,success,,6.0,"[3, 4, 7, 10, 14, 17]",ring_size_17/standard/numbered/ML00010341_numbered.png,2026-03-19 06:58:47.378341
8756,ML00005719,,,CCCCC/C=C/C=C/C(=O)CCCCCCCC(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H]1C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CO)C(=O)NCC(=O)O[C@@H]1C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8757,ML00000374,CHEMBL2323286,,CC(C)[C@@H]1NC(=O)Cn2nnc(n2)-c2csc(n2)CNC(=O)C[C@@H](/C=C/CCS)OC1=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8758,ML00000616,CHEMBL4089459,,CC(C)C[C@@H]1NC(=O)OC(c2cccc(Cl)c2)CCCCCNC(=O)CC[C@@H](C(=O)C(=O)NC2CC2)NC1=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8759,ML00004687,,,CSC1[C@H]2C(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@H](NC(=O)c3cnc4ccccc4n3)C(=O)N[C@@H](C)C(=O)N(C)[C@@H](C[S+]1C)C(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@H](NC(=O)c1cnc3ccccc3n1)C(=O)N[C@@H](C)C(=O)N2C,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8760,ML00009870,,,CCCCCCCC(=O)OCC/C=C\[C@H]1O[C@@H]1[C@@H]1OC(=O)/C=C\C=C/[C@@](OC)(C(C)=O)NC(=O)/C=C(/C)CC[C@@H]2O[C@H]2[C@@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8761,ML00008753,,,CC[C@@H]1OC(=O)CCCC/C=C\C/C=C\C/C=C\C[C@@H]1O,standard_macrolactone,17.0,,,success,,2.0,"[3, 4]",ring_size_17/standard/numbered/ML00008753_numbered.png,2026-03-19 06:58:47.438947
8762,ML00000653,CHEMBL4083679,,CCCCCC1CCCCCNC(=O)CC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)O1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8763,ML00004783,,,CCNC1C=C2C=CCC3C4C=CC(C1COC(=O)C15OC1(C/C(CO)=C(/C)CCc1ccnc(NCNC)c1)C(=O)c1cccc(c1C5=O)CC(C)(Cc1ccc(N)nc1)CCC4)C23,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8764,ML00010122,,,C/C=C(C)/C=C(\C)C[C@H](C)[C@H](O)[C@H](O)[C@H]1C/C=C\C=C/[C@H](O)C[C@H](O)[C@@H](CO)c2nc(cs2)/C=C(/C)C(=O)O1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8765,ML00008854,,,CCCCCCCC(=O)OCC/C=C/[C@H](O)[C@H](O)[C@@H]1OC(=O)/C=C\C=C/c2nc(oc2C)/C=C(/C)CC[C@@H]2O[C@H]2[C@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8766,ML00009428,,,CC[C@H](C)C[C@H](C)[C@H]1OC(=O)[C@H](Cc2ccccc2)NC(=O)/C(C)=C\[C@H](C)[C@@H](O)/C(C)=C\[C@H](C)[C@H](OC(C)=O)/C(C)=C\[C@@H]1C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8767,ML00010999,,,CC[C@H]1/C=C\[C@@H]([C@@H](O)C=C(C)C)OC(=O)/C(C)=C\CC(=O)Nc2cc(O)cc3c2O[C@@]2(CC1)CC(=O)[C@@H](C)[C@@H]3O2,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8768,ML00004762,,,CC(C)[C@H]1C(=O)OC[C@H](NC(=O)c2cnc3ccccc3n2)C(=O)N[C@@H](C)C(=O)N(C)[C@@H]2C(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@H](NC(=O)c3cnc4ccccc4n3)C(=O)N[C@@H](C)C(=O)N(C)[C@@H](C[S+]([O-])C2[S+](C)[O-])C(=O)N1C,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8769,ML00004629,,,CCNC1C=C2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C=C(/C)C4(C(NC(=N)NC)c6ccnc(NCNC)c6)CCCC4)C5=O)C(=O)OCC1CC23,standard_macrolactone,17.0,,,success,,3.0,"[12, 12, 16]",ring_size_17/standard/numbered/ML00004629_numbered.png,2026-03-19 06:58:47.522637
8770,ML00006734,,,CN1C2CCC1C1COC(=O)Cc3ccc(cc3)CC(=O)Nc3ccc(cc3)C1C2,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8771,ML00004487,,,CCSC1C2C(=O)N(C)C3(CC3C)C(=O)OCC(NC(=O)c3nc4ccccc4cc3O)C(=O)NC(C)C(=O)N(C)C(CS1=O)C(=O)N(C)C1(CC1C)C(=O)OCC(NC(=O)c1nc3ccccc3cc1O)C(=O)NC(C)C(=O)N2C,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8772,ML00010787,,,CCC[C@H](O)CC[C@@H](C)[C@@H]1OC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)CCO)N(C)C(=O)[C@]2(C)CN(O2)C(=O)[C@H](C)NC(=O)C1(C)C,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8773,ML00004672,,,CCNC1C=C2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C=C(/C)CC(NC(=N)NC)c4ccnc(NCNC)c4)C5=O)C(=O)OCC1CC23,standard_macrolactone,17.0,,,success,,3.0,"[12, 12, 16]",ring_size_17/standard/numbered/ML00004672_numbered.png,2026-03-19 06:58:47.579612
8774,ML00004481,,,CCNC1CC2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C(CO)=C(/C)CCc4ccnc(NCNC)c4)C5=O)C(=O)OC(CCCO)C1CC23,standard_macrolactone,17.0,,,success,,4.0,"[3, 12, 12, 16]",ring_size_17/standard/numbered/ML00004481_numbered.png,2026-03-19 06:58:47.620155
8775,ML00005691,,,C[C@H](O)CCC/C=C/C=C/C(=O)CCCCCCCC(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H]1C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CO)C(=O)NCC(=O)O[C@@H]1C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8776,ML00000999,CHEMBL4091852,,CC(C)C[C@@H]1NC(=O)OC(Cc2ccccc2)CCCCCNC(=O)CC[C@@H](C=O)NC1=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8777,ML00004634,,,CCC(C)SC1SCC2C(=O)N(C)C3(CC3C)C(=O)OCC(NC(=O)c3nc4ccccc4cc3O)C(=O)NC(C)C(=O)N(C)C1C(=O)N(C)C1(CC1C)C(=O)OCC(NC(=O)c1nc3ccccc3cc1O)C(=O)NC(C)C(=O)N2C,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8778,ML00009370,,,CCCC(=O)N[C@@H](C(C)C)[C@@H](CC(=O)O[C@@H]1COC(=O)c2csc(n2)[C@@H]([C@@](C)(O)CC)OC(=O)[C@@H](C)[C@H](CCCC(C)(Cl)Cl)OC(=O)c2csc1n2)OC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8779,ML00010755,,,CC[C@H]1OC(=O)CC[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)N(C)C/C=C/C(C)=C/[C@@H]1CO,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8780,ML00008499,,,COc1cc(O)c2c(c1)/C=C/CC(=O)OCCOC(=O)CCC[C@H](C)OC2=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8781,ML00002300,,,CO[C@H]1[C@H](OC(C)=O)CC(=O)O[C@@H](C)C/C=C\C=C/C(=O)[C@H](C)C[C@@H](C=O)C[C@H]1O[C@H]1O[C@@H](C)[C@H](O[C@H]2C[C@@](C)(O)[C@H](OC(=O)CC(C)C)[C@@H](C)O2)[C@@H](N(C)C)[C@@H]1O,standard_macrolactone,17.0,,,success,,7.0,"[3, 9, 10, 12, 14, 15, 16]",ring_size_17/standard/numbered/ML00002300_numbered.png,2026-03-19 06:58:47.711449
8782,ML00009232,,,C#CCCCC1OC(=O)CCNC(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H]([C@H](C)CC)NC(=O)C1(C)C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8783,ML00010672,,,CCCCCCCC(=O)OCC/C=C/[C@H]1O[C@H]1[C@H]1OC(=O)/C=C\C=C/C(=O)NC(=O)/C=C(/C)CC[C@H]2O[C@H]2[C@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8784,ML00000122,CHEMBL2011789,METACRIDAMIDE A,CC[C@H](C)C[C@H](C)[C@H]1OC(=O)[C@H](Cc2ccccc2)NC(=O)/C(C)=C/[C@H](C)[C@@H](O)/C(C)=C/[C@H](C)[C@H](OC(C)=O)/C(C)=C/[C@@H]1C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8785,ML00004542,,,CNCNc1cc(C(C/C(C)=C/CC23OC24C(=O)OCC2CC5C(=CC2NCC2CCCCC2)C=CCC5CCCCC(C)(Cc2ccc(N)nc2)Cc2cccc(c2C4=O)C3=O)NC(=N)NC)ccn1,standard_macrolactone,17.0,,,success,,3.0,"[12, 12, 16]",ring_size_17/standard/numbered/ML00004542_numbered.png,2026-03-19 06:58:47.763689
8786,ML00009052,,,CCCCCCCC(=O)OCC[C@@H](O)/C=C/[C@H](O)[C@@H]1OC(=O)/C=C\C=C/c2nc(oc2C)/C=C(/C)CC[C@@H](O)[C@@H](O)[C@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8787,ML00008689,,,O=C1COc2cc(ccc2[N+](=O)[O-])Oc2ccc(cc2Cl)C(=O)CCCCO1,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8788,ML00009093,,,O=C1OC[C@H]2O[C@@H](O)[C@H](O)[C@H](O)[C@@H]2OC(=O)c2cc(O)c(O)c(O)c2-c2c(O)c(O)c3oc(=O)c4c(c(O)c(O)c5oc(=O)c2c3c54)-c2c1cc(O)c(O)c2O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8789,ML00006656,,,CC(C)[C@@H]1OC(=O)[C@@H](C)[C@H](CCC[C@@H](C)Cl)OC(=O)c2csc(n2)[C@H](O)COC(=O)c2csc1n2,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8790,ML00006466,,,O=C1O[C@@H]2[C@@H](OC(=O)c3ccccc3-c3ccccc31)[C@@H](O)O[C@@H]1COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c4oc(=O)c5c(ccc6oc(=O)c3c4c65)-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]21,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8791,ML00007391,,,CC[C@@H]1/C=C/[C@H](O)[C@H](C)OC(=O)/C(C)=C/[C@@H]2C(=O)NC3=CC(=O)c4c(cc(C)c(O)c4C(=O)CC1)[C@@]32O,standard_macrolactone,17.0,,,success,,6.0,"[3, 4, 7, 10, 14, 17]",ring_size_17/standard/numbered/ML00007391_numbered.png,2026-03-19 06:58:47.839355
8792,ML00005685,,,CCNC1C=C2C=CCC3CCCCC(C)Cc4cccc5c4C(=O)C4(OC4(C/C=C(/C)CC(NC(=N)NC)c4ccnc(NCNC)c4)C5=O)C(=O)OCC1CC23,standard_macrolactone,17.0,,,success,,2.0,"[12, 16]",ring_size_17/standard/numbered/ML00005685_numbered.png,2026-03-19 06:58:47.867615
8793,ML00004789,,,CCC(C)C1C(=O)OCC(NC(=O)c2cnc3ccccc3n2)C(=O)NC(C)C(=O)N(C)C2C(=O)N(C)C(C(C)CC)C(=O)OCC(NC(=O)c3cnc4ccccc4n3)C(=O)NC(C)C(=O)N(C)C(CSC2SC)C(=O)N1C,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8794,ML00008033,,,O=C1CCCCCCCCC(=O)OCCCCCO1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8795,ML00011000,,,CC/C1=C/[C@@H]([C@@H](O)C=C(C)C)OC(=O)/C(C)=C\CC(=O)Nc2cc(O)cc3c2O[C@]2(CCC1)CC(=O)[C@@H](C)[C@H]3O2,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8796,ML00000980,CHEMBL506814,PUNICALAGIN,O=C1O[C@@H]2[C@@H](OC(=O)c3cc(O)c(O)c(O)c3-c3c1cc(O)c(O)c3O)[C@H](O)O[C@@H]1COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c4oc(=O)c5c(c(O)c(O)c6oc(=O)c3c4c65)-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]21,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8797,ML00010735,,,CC[C@H]1OC(=O)CC[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)CN(C)CC/C(C)=C/[C@@H]1CO,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8798,ML00004780,,,CSC1C2C(=O)N(C)C3(CC3C)C(=O)OCC(NC(=O)c3nc4ccccc4cc3O)C(=O)NC(C)C(=O)N(C)C(CS1=O)C(=O)N(C)C1(CC1C)C(=O)OCC(NC(=O)c1nc3ccccc3cc1O)C(=O)NC(C)C(=O)N2C,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
8799,ML00006672,,,CC(C)[C@@H]1OC(=O)[C@@H](C)[C@H](CCCC(C)(Cl)Cl)OC(=O)c2csc(n2)[C@H](O)COC(=O)c2csc1n2,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8800,ML00000617,CHEMBL4073819,,O=C[C@@H]1CCC(=O)NC/C=C/CCC(c2cccc(Cl)c2)OC(=O)N[C@@H](CC2CCCCC2)C(=O)N1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8801,ML00005922,,,CCNC1CC2C=CCC3CCCCC(C)Cc4cccc5c4C(=O)C4(OC4(C/C(CO)=C(/C)CCc4ccnc(NCNC)c4)C5=O)C(=O)OCC1CC23,standard_macrolactone,17.0,,,success,,2.0,"[12, 16]",ring_size_17/standard/numbered/ML00005922_numbered.png,2026-03-19 06:58:47.949513
8802,ML00010472,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\CC[C@@]56OCC/C(=C\C(=O)OC[C@H](C1)[C@@H]2[C@]4(C)[C@@]31CO1)[C@@H]5O[C@H](O)[C@H]6O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8803,ML00006647,,,C[C@H]1CC[C@@H](C)C(=O)N(C)/C=C\C=C/CC[C@H](C)C(=O)O[C@H](C(C)(C)C)C1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8804,ML00010377,,,CC(O)C1/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5O[C@]5(C)CC[C@]4(COC(=O)C4OC4(C)C(O)CO1)[C@]2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8805,ML00005999,,,CC(C)[C@@H]1OC(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8806,ML00003968,,,CC(=O)O[C@H]1CC(=O)OCC2=C3C[C@H]4[C@](O)(COC(=O)/C(C)=C\COC1=O)[C@H]1C[C@H]1[C@]4(C)[C@@H]1C[C@@]4(O)C5=C(C6=C(C)C(=O)O[C@]6(O)C(=O)[C@@]5(C)[C@@H]5C[C@@H]54)[C@]31OC2=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8807,ML00007211,,,C/C1=C/C(C)CC(C)OC(=O)C(C)NC(=O)C(Cc2ccc(O)c(I)c2)N(C)C(=O)CNC(=O)C(C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8808,ML00009832,,,CC(C)C[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8809,ML00010990,,,CC(=O)O[C@@]1(C)CC(=O)OC[C@]23CCC(C)=C[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C/[C@@H]([C@H](C)O)OC[C@H]1O)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8810,ML00003330,,,CC1=C2[C@@H]3[C@]45OC(=O)C6=C4C[C@H]4[C@](O)(COC(=O)/C=C(/C)COC(=O)CCC(=O)OC6)[C@H]6C[C@H]6[C@]4(C)[C@@H]5C=C4[C@H]5C[C@H]5[C@](C)(C(=O)[C@@]2(O)OC1=O)[C@@]43O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8811,ML00004131,,,C/C1=C/Cc2ccc([nH]2)C2=N[C@@H](/C=C3C(=C(\C)CCCO)/CO[C@H]/3CC(C)C)[C@@H](COC(=O)[C@@H](CC(C)C)CC(=O)O[C@@H]3[C@@H]1OC(=O)[C@]3(C)CO)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8812,ML00008934,,,COc1ccc2cc1C(=O)OC[C@H]1O[C@H](Oc3cc4c(c(OC)c3C)C(=O)C[C@H](O4)c3ccc(OC)c-2c3)[C@H](OC)[C@H](OC)[C@H]1OC,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8813,ML00009994,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8814,ML00000615,CHEMBL578929,,CC1CC(C)CC(C)C(O)C(C#N)=CC=CCC(C2CCCC2C(=O)O)OC(=O)CC(O)C(C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00000615_numbered.png,2026-03-19 06:58:48.093410
8815,ML00004093,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)OCc2cn(-c3cnc4ccccc4c3)nn2)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00004093_numbered.png,2026-03-19 06:58:48.153065
8816,ML00009865,,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@H](/C=C/[C@@H]3CC(C)=CCO3)O[Si](C)(C)C(C)(C)C)C[C@@H]3O[C@H]3[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8817,ML00011026,,,CC(C)/C=C/C=C/C[C@@H]1NC(=O)[C@H]2C[C@@H](O)CNN2C(=O)COC(=O)[C@](C)(CO)NC(=O)[C@H]2C[C@H](O)CNN2C(=O)[C@H]2C[C@H](Cl)CNN2C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8818,ML00010085,,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@@H]3CC(C)=CC(=O)O3)C[C@@H]3O[C@H]3[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8819,ML00008702,,,C[C@@H]1CCCCCCCCCC[C@H](O)[C@@H](O)[C@@H](O)/C=C\C(=O)O1,standard_macrolactone,18.0,,,success,,4.0,"[3, 14, 15, 16]",ring_size_18/standard/numbered/ML00008702_numbered.png,2026-03-19 06:58:48.223060
8820,ML00008690,,,C[C@@H]1CCCCCCCCCC[C@H](O)[C@@H](O)[C@@H](O)CCC(=O)O1,standard_macrolactone,18.0,,,success,,4.0,"[3, 14, 15, 16]",ring_size_18/standard/numbered/ML00008690_numbered.png,2026-03-19 06:58:48.262664
8821,ML00001030,CHEMBL221540,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@H](C)[C@H](C)C(=O)O)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00001030_numbered.png,2026-03-19 06:58:48.317654
8822,ML00010330,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(N)=O)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010330_numbered.png,2026-03-19 06:58:48.372961
8823,ML00009824,,,CCC(C)C1C(=O)OC(C(C)C)C(=O)N(C)C(C(C)CC)C(=O)OC(C(C)C)C(=O)N(C)C(C(C)CC)C(=O)OC(C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8824,ML00001385,CHEMBL4095773,,CC1=C2C3=C4[C@](O)(C[C@H]5[C@@]6(C)[C@@H]7C[C@@H]7[C@@]7(O)COC(=O)/C=C(\C)COC(=O)CCC(=O)OCC8=C(C[C@@H]76)[C@@]35OC8=O)[C@H]3C[C@H]3[C@]4(C)[C@@H](O)[C@@]2(O)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8825,ML00000618,CHEMBL1611678,,CO[C@@H]1COC(=O)[C@H]2CCCN2C(=O)[C@@H](C)COC(=O)[C@H](COCc2ccccc2)NC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8826,ML00007227,,,C[C@@H]1CCOC(=O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H](Br)[C@](C)(O)CC[C@]4(COC(=O)[C@H]1O)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8827,ML00007231,,,CC1=CC2OC3CC4OC(=O)/C=C\C=C\C(=O)OCCC(C)C(O)C(=O)OCC2(CC1O)C4(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8828,ML00000320,CHEMBL2206980,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(OCc4ncn(C)n4)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8829,ML00000297,CHEMBL2206969,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(NC)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8830,ML00007554,,,C=C1C[C@@H](CCC)OC(=O)[C@@H](C)CCCC[C@@H]2O[C@@H](CC(=O)[C@@H](O)[C@H](C)C1)C[C@@H]2C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8831,ML00003380,,,CC1=C2C3=C4[C@](O)(C[C@H]5[C@@]6(C)[C@@H]7C[C@@H]7[C@@]7(O)COC(=O)/C(C)=C\COC(=O)CCC(=O)OCC8=C(C[C@@H]76)[C@@]35OC8=O)[C@H]3C[C@H]3[C@]4(C)[C@@H](O)[C@@]2(O)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8832,ML00003381,,,CC1=C2C3=C4[C@](O)(C[C@H]5[C@@]6(C)[C@@H]7C[C@@H]7[C@@]7(O)COC(=O)/C(C)=C/COC(=O)CCC(=O)OCC8=C(C[C@@H]76)[C@@]35OC8=O)[C@H]3C[C@H]3[C@]4(C)[C@@H](O)[C@]2(O)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8833,ML00000685,CHEMBL1672606,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCc1cc3c(nccc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8834,ML00006197,,,CC(C)CCCCCCCCCCCC[C@@H]1O[C@H]2O[C@@H](COC(=O)[C@H](C)[C@@H](CCCCCCCCCCCC(C)C)O[C@@H]3O[C@H](COC(=O)[C@H]1C)[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@@H](O)[C@@H]2O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8835,ML00010121,,,C/C=C(C)/C=C(\C)C[C@H](C)[C@H](O)[C@@H]1OC(=O)/C(C)=C\c2csc(n2)[C@@H](CO)[C@@H](O)C[C@H](O)/C=C\C=C/C[C@H]1O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8836,ML00009827,,,CC[C@H](C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8837,ML00004147,,,CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@](C)(C(=O)[C@H](O)C1=C(C)C3C[C@@](O)([C@H](C)OC(=O)CC/C=C\CCC(=O)N[C@@H](c4ccccc4)[C@@H](O)C(=O)O3)C1(C)C)C2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8838,ML00010385,,,CC1=C[C@@H]2O[C@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC/C(C)=C\C(=O)OC[C@]2(CC1)[C@@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8839,ML00000164,CHEMBL4065225,,CC(C)C[C@@H]1NC(=O)OC(c2cccc(Cl)c2)CCCCCONC(=O)CC[C@@H](C=O)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8840,ML00007226,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/C(=O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8841,ML00007551,,,C=C1C[C@H](C)C(=O)[C@@H](O)C[C@H]2C[C@H](C)[C@H](CCCC[C@H](C)C(=O)O[C@H](CCC)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8842,ML00000605,CHEMBL1365512,,Cc1ccc(S(=O)(=O)N[C@H]2COC(=O)C/C=C/[C@@H](C)[C@H]3C=C[C@H](O)[C@@H](COC(=O)C/C=C/[C@H]2C)O3)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8843,ML00002832,,,CC(C)[C@@H]1OC(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8844,ML00000613,CHEMBL3355648,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)O)C/C=C/C=C(/CN)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00000613_numbered.png,2026-03-19 06:58:48.600510
8845,ML00009402,,,CC[C@H](C)[C@H]1OC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)C(=O)[C@@H](CC(C)C)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8846,ML00007262,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccc(O)c(Br)c2)N(C)C(=O)CNC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8847,ML00001362,CHEMBL2426331,,CO[C@@H]1C(=O)O[C@H](C)[C@H](C)/C=C(\C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1ccc(N)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8848,ML00007233,,,CC1CCOC(=O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5O[C@]5(C)CC[C@]4(COC(=O)C1O)[C@]2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8849,ML00003413,,,C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@@H](CC)[C@@H](O)[C@H](C)C/C(C)=C\C=C/[C@H]2OC)C[C@@H](O)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00003413_numbered.png,2026-03-19 06:58:48.692524
8850,ML00009823,,,CCCC[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)CC)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](CCCC)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8851,ML00010662,,,C/C=C/C(=O)O[C@H]1C[C@@]23COC(=O)[C@@H](O)[C@H](C)CCO[C@@H]([C@H](C)O)/C=C\C=C\C(=O)O[C@@H]4C[C@@H](O[C@@H]2C=C1C)[C@@]1(CO1)[C@]43C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8852,ML00007552,,,C=C1C[C@@H](CCC)OC(=O)[C@@H](C)CCCC[C@@H]2O[C@@H](C[C@H](O)C(=O)[C@H](C)C1)C[C@@H]2C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8853,ML00009982,,,C=C1C[C@H]2C/C=C\[C@@H](O)[C@@H](C)/C(C)=C\C(=O)O[C@H](C[C@@H](C)[C@H](C)O)[C@@H](C)C/C=C\[C@@](C)(O)[C@@](O)(C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8854,ML00007210,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](CO)NC(=O)[C@@H](Cc2ccc(O)c(I)c2)N(C)C(=O)CNC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8855,ML00007629,,,C=C1C[C@@H](CC[C@H](C)O)OC(=O)[C@@H](C)CCCC[C@@H]2O[C@H](C[C@@H]2C)C[C@@H](O)C(=O)[C@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8856,ML00010013,,,C[C@H]1CC(=O)OC[C@@]23CC[C@@]4(C)O[C@H]4[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OC[C@H]1O)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8857,ML00010343,,,CC1=C[C@@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC[C@@]5(C)O[C@@H]5C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8858,ML00010974,,,C=C1C[C@H](C)C[C@@]2(C)CC=C[C@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@H]3CC(C)=CCO3)C[C@@H]3O[C@H]3[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8859,ML00004111,,,COC(=O)/C(C)=C1\C(=O)[C@@H](O)[C@@]2(C)C3=C([C@@H](O)[C@@H]4[C@@]5(OC(=O)C6=C5C[C@@H]5[C@@](O)(COC(=O)/C=C(/C)COC(=O)CCC(=O)OC6)[C@@H]6C[C@@H]6[C@]54C)[C@@H]31)[C@@H]1C[C@@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8860,ML00007605,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\C(=O)OCC/C(C)=C/C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8861,ML00000734,CHEMBL1672596,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCOCC1)NC(=O)OCCC/C=C/c1ccc3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8862,ML00004159,,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C(C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C(C)=C\COC(=O)CCC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@H]31)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8863,ML00009900,,,CC(C)C[C@H]1C(=O)O[C@H](Cc2ccccc2)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8864,ML00007339,,,C=C1C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2ccc(O)c(Cl)c2)C(=O)N[C@@H](C)C(=O)O[C@@H](C)C[C@@H](C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8865,ML00010031,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@@H]([C@H](C)O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(CC1)[C@]4(C)[C@@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8866,ML00001165,CHEMBL154035,,C=C1C[C@H](O)/C=C/C[C@@H]([C@@H](O)/C=C/[C@@H]2CC(C)=CCO2)OC(=O)/C=C/C[C@@H]2C=CC[C@@H](C[C@@H](C)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8867,ML00002537,,,CC(C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8868,ML00010848,,,C=C1C[C@@H]2C/C=C\[C@H](O)[C@H](C)/C(C)=C\C(=O)O[C@H](CC[C@@H](C)[C@H](C)O)[C@@H](C)C/C=C\[C@@](C)(O)[C@](O)(C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8869,ML00002479,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)OCc2cn(C34CC5CC(CC(C5)C3)C4)nn2)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00002479_numbered.png,2026-03-19 06:58:48.929356
8870,ML00006407,,,CC=C[C@H]1O[C@@](O)([C@H](C)C(O)C(C)[C@@H]2OC(=O)C(OC)=CC(C)=C[C@H](C)[C@H](O)[C@H](CC)[C@H](O)C(C)CC(C)=CC=C[C@H]2OC)C[C@@H](O[C@@H]2C[C@H](O)[C@@H](OC(N)=O)[C@H](C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00006407_numbered.png,2026-03-19 06:58:49.002751
8871,ML00000385,CHEMBL1414358,,CO[C@H]1COC(=O)[C@@H](CCSC)NC(=O)C/C=C\[C@@H](C)COC(=O)[C@@H](OCc2ccccc2)/C=C\[C@@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8872,ML00000798,CHEMBL398304,BEAUVERICIN G2,CC[C@H]1OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](CC)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8873,ML00001961,CHEMBL347678,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@H](/C=C/[C@@H]3CC(C)=CCO3)OC(C)=O)C[C@@H]3O[C@H]3[C@@H](OC(C)=O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8874,ML00004106,,,CO[C@@]12OC(=O)C(C)=C1C1=C3[C@](O)(C[C@H]4[C@@]5(C)[C@@H]6C[C@@H]6[C@@]6(O)COC(=O)/C=C(/C)COC(=O)CCC(=O)OCC7=C(C[C@@H]65)[C@@]14OC7=O)[C@H]1C[C@H]1[C@]3(C)[C@H]2O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8875,ML00009264,,,C=C1[C@@H](OC)C/C=C\[C@@H](O[C@@H]2O[C@H](OC)[C@@H](O)[C@H](OC)[C@H]2O)CC(=O)O[C@@H](/C=C(/C)C/C=C/C)C/C=C\C=C/C[C@H](C)[C@@H]1OO,standard_macrolactone,18.0,,,success,,6.0,"[3, 10, 11, 12, 13, 17]",ring_size_18/standard/numbered/ML00009264_numbered.png,2026-03-19 06:58:49.095821
8876,ML00010020,,,C/C1=C\C(=O)OC[C@]23CCC(CO)=C[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C\[C@H]([C@@H](C)O)OCC1)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8877,ML00011025,,,CC(C)/C=C/C=C/C[C@@H]1NC(=O)[C@H]2C[C@@H](O)CNN2C(=O)COC(=O)[C@](C)(CO)NC(=O)[C@@H]2C[C@H](O)CNN2C(=O)[C@H]2C[C@H](Cl)CNN2C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8878,ML00000307,CHEMBL2206973,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(O)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8879,ML00000301,CHEMBL2206982,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc4nccn4c3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8880,ML00010024,,,CC1=C[C@@H]2O[C@H]3[C@@H](O)[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC/C(C)=C\C(=O)OC[C@]2(CC1)[C@@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8881,ML00010457,,,C/C1=C\C(=O)OC[C@]23CC[C@]4(C)O[C@H]4[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C\[C@H]4O[C@H](C1)O[C@@H]4C)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8882,ML00006875,,,C=C1CCC[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H](CO)C/C=C/[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8883,ML00007332,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8884,ML00003382,,,CC1=C2C3=C4[C@](O)(C[C@H]5[C@@]6(C)[C@@H]7C[C@@H]7[C@@]7(O)COC(=O)/C(C)=C/COC(=O)CCC(=O)OCC8=C(C[C@@H]76)[C@@]35OC8=O)[C@H]3C[C@H]3[C@]4(C)[C@@H](O)[C@@]2(O)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8885,ML00008856,,,C/C1=C/[C@@H](C)[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8886,ML00009036,,,COc1ccc(C[C@@H]2NC(=O)[C@H](CC(C)C)OC(=O)[C@H](C(C)C)OC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)N(C)C2=O)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8887,ML00000676,CHEMBL1672600,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCc1cc(OCC)c3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8888,ML00000682,CHEMBL1672588,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCCC/C=C/c1ccc3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8889,ML00010400,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OC[C@H](O)[C@@]5(C)O[C@@H]5C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8890,ML00009403,,,CC[C@@H](C)[C@@H]1OC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)C(=O)[C@H](CC(C)C)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8891,ML00007603,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/C(=O)OC/C(C)=C\CC(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8892,ML00010026,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC/C(C)=C\C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8893,ML00010695,,,CCCCC/C=C\C(C)=C\[C@@H]1C[C@H](C)C/C=C\CC[C@@H](O)[C@H](OC(N)=O)CC[C@@H](C)C[C@H](OC(N)=O)[C@H](C)C(=O)O1,standard_macrolactone,18.0,,,success,,7.0,"[3, 5, 11, 12, 15, 17, 18]",ring_size_18/standard/numbered/ML00010695_numbered.png,2026-03-19 06:58:49.277668
8894,ML00009215,,,CC(C)C[C@@H]1C(=O)N2C[C@@H](C)C[C@H]2C(=O)N[C@H](C(C)C)C(=O)O[C@@H](C(C)C)C(=O)N2NCCC[C@@H]2C(=O)N2NCCC[C@H]2C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8895,ML00007228,,,CC1CCOC(=O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4C[C@@H](C)C(=O)C[C@]4(COC(=O)C1O)[C@]2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8896,ML00007218,,,CC1CCOC(=O)C=CC=CC(=O)OC2CC3OC4C5OC5(C)C(O)CC4(COC(=O)C1O)C2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8897,ML00007022,,,C/C1=C(\C)CCCCCOC(=O)c2ccccc2C(=O)OCCCCC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8898,ML00007239,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/C(=O)OC/C(CO)=C\CC(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8899,ML00010334,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)O)C/C=C\C=C(\C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010334_numbered.png,2026-03-19 06:58:49.359855
8900,ML00006351,,,CC[C@H](C)[C@H]1OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]([C@@H](C)CC)OC(=O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8901,ML00004192,,,CO[C@]12OC(=O)C(C)=C1C1=C3[C@](O)(C[C@H]4[C@@]5(C)[C@@H]6C[C@@H]6[C@@]6(O)COC(=O)/C(C)=C\COC(=O)CCC(=O)OCC7=C(C[C@@H]65)[C@@]14OC7=O)[C@H]1C[C@H]1[C@]3(C)C2=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8902,ML00010040,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC[C@H](C)[C@@H](O)C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8903,ML00003414,,,C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@@H]2OC(=O)/C(OC)=C\C(C)=C/[C@H](C)[C@@H](O)[C@@H](CC)[C@@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H]2OC)C[C@@H](O)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00003414_numbered.png,2026-03-19 06:58:49.436410
8904,ML00009372,,,COC[C@@H]1NC(=O)[C@@H]2CCCNN2C(=O)[C@H](C(C)(C)C)OC(=O)[C@@H](C2(C)CC2)NC(=O)[C@@H]2C[C@@]3(O)c4ccc(Cl)c(Cl)c4N[C@H]3N2C(=O)[C@@H]([C@H](O)CC(=O)O)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8905,ML00000461,CHEMBL2063081,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1ccc3c(c1)c(nc1ccccc13)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8906,ML00010694,,,CCCCC/C=C/C(C)=C\[C@@H]1C[C@H](C)C/C=C\CC[C@@H](O)[C@H](OC(N)=O)CC[C@@H](C)C[C@H](OC(N)=O)[C@H](C)C(=O)O1,standard_macrolactone,18.0,,,success,,7.0,"[3, 5, 11, 12, 15, 17, 18]",ring_size_18/standard/numbered/ML00010694_numbered.png,2026-03-19 06:58:49.494699
8907,ML00007473,,,O=C[C@@H]1CCC(=O)NCCCCCCC(c2cccc(Cl)c2)OC(=O)NC2(CCCCC2)C(=O)N1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8908,ML00004191,,,COC(=O)/C(C)=C1/C(=O)[C@H](O)[C@]2(C)C3=C(C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C(C)=C\CCC(=O)OCC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@H]31)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8909,ML00009274,,,C=C1[C@@H](OC)C/C=C\[C@@H](O[C@@H]2O[C@H](OC)[C@@H](O)[C@H](OC)[C@H]2O)CC(=O)O[C@@H](/C=C(\C)C/C=C\C)C/C=C\C=C/C[C@H](C)[C@@H]1OO,standard_macrolactone,18.0,,,success,,6.0,"[3, 10, 11, 12, 13, 17]",ring_size_18/standard/numbered/ML00009274_numbered.png,2026-03-19 06:58:49.549559
8910,ML00000813,CHEMBL4092734,,COC(=O)/C(C)=C1/C(=O)[C@H](O)[C@]2(C)C3=C(C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C=C(\C)COC(=O)CCC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@H]31)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8911,ML00008703,,,C[C@H]1CCCCCCCCCC[C@@H](O)[C@H](O)[C@H](O)/C=C\C(=O)O1,standard_macrolactone,18.0,,,success,,4.0,"[3, 14, 15, 16]",ring_size_18/standard/numbered/ML00008703_numbered.png,2026-03-19 06:58:49.589037
8912,ML00000681,CHEMBL2063084,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCC/C=C/c1nc3ccccc3cc1O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8913,ML00003376,,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@@H]2C3=C1[C@]14OC(=O)C5=C1C[C@H]1[C@](O)(COC(=O)/C(C)=C\COC(=O)[C@@H](O)CC(=O)OC5)[C@H]5C[C@H]5[C@]1(C)[C@@H]4C[C@]3(OO)[C@H]1C[C@@H]21,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8914,ML00010056,,,CC(O)C1/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4C=C(CO)CC[C@]4(COC(=O)C(O)C(C)CCO1)[C@]2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8915,ML00010786,,,CCCCC/C=C/C(C)=C/[C@@H]1C[C@H](C)C/C=C\CC[C@H](O)[C@@H](O)CC[C@H](C)C[C@@H](O)[C@@H](C)C(=O)O1,standard_macrolactone,18.0,,,success,,7.0,"[3, 5, 11, 12, 15, 17, 18]",ring_size_18/standard/numbered/ML00010786_numbered.png,2026-03-19 06:58:49.650076
8916,ML00003415,,,C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](CC)[C@@H](O)[C@H](C)C/C(C)=C/C=C/[C@@H]2OC)C[C@@H](O)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00003415_numbered.png,2026-03-19 06:58:49.704276
8917,ML00008901,,,CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)OC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8918,ML00008811,,,C/C1=C\[C@H](C)C[C@H](C)OC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccc(O)c(I)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8919,ML00010062,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OC[C@H](O)[C@@H](C)CC(=O)OC[C@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8920,ML00000712,CHEMBL2063079,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1ccc3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8921,ML00000061,CHEMBL136985,VERRUCARIN A,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\C(=O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8922,ML00010451,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]5O[C@H](O[C@@H]5C)[C@@H](O)/C(C)=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8923,ML00001035,CHEMBL221697,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CC[C@H]2C(=O)O)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00001035_numbered.png,2026-03-19 06:58:49.789377
8924,ML00005608,,,C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H]2OC)C[C@@H](O[C@H]2C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00005608_numbered.png,2026-03-19 06:58:49.846516
8925,ML00009216,,,CC(C)C[C@@H]1C(=O)N2C[C@H](C)C[C@H]2C(=O)N[C@H](C(C)C)C(=O)O[C@@H](C(C)C)C(=O)N2NCCC[C@@H]2C(=O)N2NCCC[C@H]2C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8926,ML00010272,,,CC[C@H]1[C@@H](O)[C@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)CO)OC(=O)/C(OC)=C/C(C)=C/[C@@H](C)[C@H]1O,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00010272_numbered.png,2026-03-19 06:58:49.910629
8927,ML00009095,,,O=C1O[C@@H]2[C@@H](COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c4oc(=O)c5c(c(O)c(O)c6oc(=O)c3c4c65)-c3cc1c(O)c(O)c3O)O[C@H](O)[C@H](O)[C@H]2O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8928,ML00006626,,,C[C@@H](O)[C@H]1C(=O)N2C3=C(S[C@@H]4CN[C@@H](C4)C(=O)Nc4cccc(c4)C(=O)OCOCOC3=O)[C@H](C)[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8929,ML00009838,,,CC[C@H](C)[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]([C@@H](C)CC)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]([C@](C)(O)CC)OC(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8930,ML00001163,CHEMBL155626,,C=C1C[C@H](O)/C=C/C[C@@H]([C@@H](O)/C=C/[C@@H]2CC(C)=CCO2)OC(=O)/C=C\C[C@@H]2C=CC[C@@H](C[C@@H](C)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8931,ML00010390,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OCC/C(C)=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8932,ML00003473,,,CC[C@@H](C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H]([C@H](C)CC)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8933,ML00000296,CHEMBL2206974,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(OC)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8934,ML00010409,,,C[C@@H](O)[C@H]1/C=C\C=C/C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5O[C@]5(C)CC[C@@]4(COC(=O)[C@H]4O[C@]4(C)[C@@H](O)CO1)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8935,ML00007242,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/C(=O)OCC/C(C)=C\C(=O)OC[C@@]2(C[C@@H]1O)[C@]4(C)[C@@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8936,ML00010707,,,CCCCC/C=C/C(C)=C/[C@@H]1C[C@H](C)C/C=C\CC[C@H](O)[C@@H](OC(N)=O)CC[C@H](C)C[C@@H](OC(N)=O)[C@@H](C)C(=O)O1,standard_macrolactone,18.0,,,success,,7.0,"[3, 5, 11, 12, 15, 17, 18]",ring_size_18/standard/numbered/ML00010707_numbered.png,2026-03-19 06:58:50.030702
8937,ML00006027,,,C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](CC)[C@@H](O)[C@H](C)C/C(C)=C/C=C/[C@@H]2OC)C[C@H](OC2CC(O)C(OC(N)=O)C(C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00006027_numbered.png,2026-03-19 06:58:50.091524
8938,ML00000691,CHEMBL1672597,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCOCC1)NC(=O)OCCCCCc1ccc3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8939,ML00010422,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@@H]([C@H](C)O)OCC/C(C)=C\C(=O)OC[C@@]2([C@H]2O[C@@H]12)[C@]4(C)[C@@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8940,ML00008962,,,CCCC[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)CC)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8941,ML00009895,,,CC(C)C[C@@H]1NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)OC(=O)[C@H](C(C)C)OC(=O)[C@H](CO)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8942,ML00010366,,,C/C1=C\C(=O)OC[C@]23CC[C@](C)(O)[C@H]4C[C@@]5(O)[C@H](O[C@H]42)[C@H](O)[C@@H](OC(=O)/C=C\C=C\[C@@H]2O[C@H](C1)O[C@H]2C)[C@@]53C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8943,ML00007340,,,C=C1C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2ccc(O)c(Br)c2)C(=O)N[C@@H](C)C(=O)O[C@@H](C)C[C@@H](C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8944,ML00010257,,,Cc1c2cc3c(c1O)C(=O)C[C@H](O3)c1ccc(O)c(c1)-c1ccc(O)c(c1)C(=O)OC[C@@H]1O[C@H](O2)[C@H](O)[C@H](O)[C@@H]1O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8945,ML00007677,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@H](C)CC(=O)O)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00007677_numbered.png,2026-03-19 06:58:50.185156
8946,ML00005115,,,CC(O)CCCCCCCCCCCCCCCC(CCCCCCCCCCCCCCC1CC(=O)OCC2OC(OC(CCCCCCCCCCCCCC(CCCCCC(C)O)OC3OC(CO)C(O)C(O)C3O)CC(=O)OCC3OC(O1)C(O)C(O)C3O)C(O)C(O)C2O)OC1OC(CO)C(O)C(O)C1O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8947,ML00003348,,,CC1=C2C3=C4[C@](O)(C[C@H]5[C@@]6(C)[C@@H]7C[C@@H]7[C@@]7(O)COC(=O)/C(C)=C/COC(=O)CCC(=O)OCC8=C(C[C@@H]76)[C@@]35OC8=O)[C@H]3C[C@H]3[C@]4(C)C(=O)[C@@]2(O)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8948,ML00010025,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@@H]([C@H](C)O)OCC/C(C)=C\C(=O)OC[C@@]2(C[C@@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8949,ML00005598,,,C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](CC)[C@@H](O)[C@H](C)C/C(C)=C/C=C/[C@@H]2OC)C[C@H](OC2CC(O)C(O)C(C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00005598_numbered.png,2026-03-19 06:58:50.264503
8950,ML00000057,CHEMBL2203882,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCC(C)(C)C[C@@H]1C[C@@H]1c1cc3c(cc(OCC)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8951,ML00010397,,,C=C1[C@H]2C[C@H]3OC(=O)/C=C\C=C\[C@H]([C@@H](C)O)OCC/C(C)=C/C(=O)OC[C@@]4(CCC(C)=C[C@H]4O2)[C@]13C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8952,ML00000857,CHEMBL1672594,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](Cc1ccccc1)NC(=O)OCCC/C=C/c1ccc3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8953,ML00006852,,,C/C1=C/C[C@H]2CCC[C@]3(CCC[C@@H]3C[C@@H](C)/C=C\[C@@H](O)/C=C(/Cl)CCOC1=O)N2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8954,ML00004102,,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C1[C@]14OC(=O)C5=C1C[C@H]1[C@](O)(COC(=O)/C(C)=C/COC(=O)CCC(=O)OC5)[C@H]5C[C@H]5[C@]1(C)[C@@H]4C[C@]3(O)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8955,ML00010452,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@@H]5O[C@@H](O[C@H]5C)[C@@H](O)/C(C)=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8956,ML00009224,,,CO[C@@H](C)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)CC[C@H](C)[C@@H]1C/C=C\C=C/C[C@@H](O)[C@@H]2O[C@H]2[C@@H](O)[C@H](C)/C=C(C)\C=C(\C)C(=O)O1,standard_macrolactone,18.0,,,success,,6.0,"[3, 10, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00009224_numbered.png,2026-03-19 06:58:50.345320
8957,ML00000041,CHEMBL435984,RORIDIN M,CC1=C[C@H]2O[C@@H]3[C@H](O)[C@H]4OC(=O)/C=C\C=C\[C@@H]5O[C@H](C/C(C)=C/C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)O[C@H]5C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8958,ML00011014,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)N[C@@H](C)C(=O)O)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00011014_numbered.png,2026-03-19 06:58:50.399340
8959,ML00010009,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\[C@H]([C@@H](C)O)OC[C@H](O)[C@@H](C)CC(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8960,ML00009477,,,COC[C@@H]1NC(=O)[C@@H]2CCC=NN2C(=O)[C@H](C(C)(C)C)OC(=O)[C@@H](C2(C)CC2)NC(=O)[C@@H]2C[C@@]3(O)c4ccc(Cl)c(Cl)c4N[C@H]3N2C(=O)[C@@H]([C@@H](O)CC(=O)O)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8961,ML00010337,,,CC1CC(C)CC(C)C(O)/C(C#N)=C\C=C/CC(C2CCCC2C(=O)O)OC(=O)CC(O)C(C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010337_numbered.png,2026-03-19 06:58:50.461420
8962,ML00010344,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OC[C@H](O)/C(C)=C\C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8963,ML00010616,,,CCCCC/C=C/C(C)=C/[C@@H]1C[C@@H](C)CCCCC[C@@H](O)[C@H](OC(N)=O)CC[C@H](C)C[C@@H](O)[C@H](C)C(=O)O1,standard_macrolactone,18.0,,,success,,7.0,"[3, 5, 11, 12, 15, 17, 18]",ring_size_18/standard/numbered/ML00010616_numbered.png,2026-03-19 06:58:50.509385
8964,ML00010559,,,CCCCC/C=C/C(C)=C/[C@@H]1C[C@H](C)C/C=C\CC[C@@H](O)[C@H](OC(N)=O)CC[C@H](C)C[C@@H](O)[C@H](C)C(=O)O1,standard_macrolactone,18.0,,,success,,7.0,"[3, 5, 11, 12, 15, 17, 18]",ring_size_18/standard/numbered/ML00010559_numbered.png,2026-03-19 06:58:50.550319
8965,ML00009410,,,CC(C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8966,ML00010975,,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@@H]3CC(C)=CCO3)C[C@@H]3O[C@H]3[C@@H](OC)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8967,ML00010108,,,CC(C)C[C@@H]1OC(=O)[C@@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC(=O)CNC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8968,ML00008906,,,CC[C@H](C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8969,ML00007182,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CC[C@H]2C(=O)O)C/C=C\C=C(\C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00007182_numbered.png,2026-03-19 06:58:50.622626
8970,ML00005788,,,CC[C@@H]1[C@H](O)[C@@H](C)/C=C(C)\C=C(\OC)C(=O)O[C@H]([C@H](C)[C@H](O)[C@H](C)[C@@]2(O)C[C@@H](O[C@H]3C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O3)[C@H](C)[C@@H](C)O2)[C@@H](OC)/C=C\C=C(\C)C[C@@H](C)[C@H]1O,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00005788_numbered.png,2026-03-19 06:58:50.687962
8971,ML00010474,,,C/C1=C/C(=O)OC[C@]23CC[C@@]4(C)O[C@H]4[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C/[C@H]4O[C@@H](O[C@@H]4C)[C@@H]1O)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8972,ML00000686,CHEMBL1672599,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCc1cc(OC)c3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8973,ML00001866,CHEMBL1555119,,CO[C@H]1COC(=O)C/C=C\[C@@H](C)COC(=O)[C@H]2CCCN2C(=O)C/C=C\[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8974,ML00008894,,,C/C1=C/C[C@@H](O)[C@@H](C)[C@H](O)C[C@H](O)/C(C)=C\[C@@H](C)CCC[C@H](C)[C@@H]([C@H](C)CCCCCCCCCC(=O)O)OC1=O,standard_macrolactone,18.0,,,success,,9.0,"[3, 4, 8, 10, 11, 13, 14, 15, 18]",ring_size_18/standard/numbered/ML00008894_numbered.png,2026-03-19 06:58:50.764652
8975,ML00009487,,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@@H]3CC(C)=CCO3)C[C@H]3O[C@@H]3[C@H](OC(=O)c3ccc([N+](=O)[O-])cc3)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8976,ML00006789,,,C[C@@H](O)[C@H]1C(=O)N2C3=C(S[C@@H]4CN[C@@H](C4)C(=O)Nc4cccc(c4)C(=O)OCCCOC3=O)[C@H](C)[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8977,ML00010259,,,Cc1c2cc3c(c1O)C(=O)C[C@H](O3)c1ccc(O)c(c1)-c1ccc(O)c(c1)C(=O)OC[C@H]1O[C@@H](O2)[C@H](O)[C@H](O)[C@@H]1O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8978,ML00008914,,,CC[C@H](C)[C@H]1NC(=O)[C@@H]2C[C@H](C)CN2C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H]2CCCNN2C(=O)[C@H]2CCCNN2C(=O)[C@H](C(C)C)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8979,ML00005759,,,C/C=C/C1OC(O)(C(C)C(O)C(C)C2OC(=O)/C(OC)=C\C(C)=C/C(C)C(O)CC(O)C(C)C/C(C)=C\C=C/C2OC)CC(OC2CC(O)C(OC(N)=O)C(C)O2)C1C,standard_macrolactone,18.0,,,success,,9.0,"[3, 4, 8, 10, 11, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00005759_numbered.png,2026-03-19 06:58:50.858866
8980,ML00001351,CHEMBL2426329,,CO[C@@H]1C(=O)O[C@H](C)[C@H](C)/C=C(\C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1ccc(C#N)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8981,ML00010033,,,CC1=CC2OC3CC4OC(=O)C=CC=CC(C(C)O)OCCC(C)C(O)C(=O)OCC2(CC1)C4(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8982,ML00003734,,,C/C=C/[C@H](O)[C@H](C)/C=C/C(=O)[C@@H](C)[C@H](O)[C@H](C)[C@@H]1OC(=O)/C(OC)=C\C(C)=C/[C@H](C)[C@@H](O)[C@@H](C)[C@@H](O)[C@H](C)C/C(C)=C\C=C/[C@H]1OC,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00003734_numbered.png,2026-03-19 06:58:50.939906
8983,ML00009227,,,CC(C)C[C@@H]1C(=O)N2C[C@H](C)C[C@H]2C(=O)N[C@H](C(C)C)C(=O)O[C@@H](C(C)C)C(=O)N2NC[C@H](Cl)C[C@@H]2C(=O)N2NCCC[C@H]2C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8984,ML00000462,CHEMBL2206960,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(nc4cc(F)ccc4c3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8985,ML00009891,,,CCC(C)[C@@H]1OC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC(=O)[C@H](C(C)C)OC(=O)C(C)(C)C(=O)[C@H](CC(C)C)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8986,ML00010038,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8987,ML00007384,,,C/C=C\C/C(C)=C/[C@H]1C/C=C\C=C/C[C@H](C)/C=C(/C)[C@@H](OC)C[C@@H](O)C[C@@H](O)CC(=O)O1,standard_macrolactone,18.0,,,success,,6.0,"[3, 10, 12, 13, 15, 17]",ring_size_18/standard/numbered/ML00007384_numbered.png,2026-03-19 06:58:51.019567
8988,ML00009951,,,CC1CC(=O)OC[C@]23C[C@@H](O)[C@H](C)C[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C\C(C(C)O)O[C@@H](O)C1)[C@@]3(C)C21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8989,ML00007328,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(O)c(Br)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8990,ML00010443,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]5O[C@H](C[C@]6(C)O[C@H]6C(=O)OC[C@@]2([C@H]2O[C@@H]12)[C@]4(C)[C@]31CO1)O[C@@H]5C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8991,ML00010352,,,C[C@@H](O)[C@H]1/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5OC5(C)CC[C@]4(COC(=O)[C@H]4O[C@]4(C)[C@@H](O)CO1)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8992,ML00007338,,,C=C1C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2ccc(O)c(I)c2)C(=O)N[C@@H](C)C(=O)O[C@@H](C)C[C@@H](C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8993,ML00000491,CHEMBL2063080,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1ccc3nc(-c4ccccc4)cc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8994,ML00010003,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OCC[C@@H](C)[C@@H](O)C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8995,ML00010132,,,C[C@@H]1CCO[C@@H]([C@@H](C)O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5C[C@]5(C)[C@H](O)C[C@]4(COC(=O)[C@H]1O)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8996,ML00003328,,,CC1=C2C3=C4[C@](O)(C[C@H]5[C@@]6(C)[C@H]7C[C@@H]7[C@@]7(O)COC(=O)/C=C(\C)COC(=O)CCC(=O)OCC8=C(C[C@@H]76)[C@@]35OC8=O)[C@H]3C[C@H]3[C@]4(C)C(=O)[C@@]2(O)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8997,ML00006835,,,CC(=O)O[C@H]1/C=C\C(=O)O[C@H](C)CCCCCCCCCC[C@H](OC(C)=O)[C@H]1OC(C)=O,standard_macrolactone,18.0,,,success,,4.0,"[3, 14, 15, 16]",ring_size_18/standard/numbered/ML00006835_numbered.png,2026-03-19 06:58:51.129059
8998,ML00008907,,,CCC(C)C1C(=O)OC(C(C)C)C(=O)N(C)C(C(C)C)C(=O)OC(C(C)C)C(=O)N(C)C(C(C)C)C(=O)OC(C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
8999,ML00009831,,,CC[C@H](C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H]([C@H](C)CC)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9000,ML00010057,,,C[C@@H]1CCO[C@@H]([C@@H](C)O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4C=C(CO)CC[C@]4(COC(=O)[C@H]1O)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9001,ML00007220,,,CC1CCOC(=O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5O[C@]5(CO)CC[C@]4(COC(=O)C1O)[C@]2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9002,ML00004259,,,CCC(=O)C1(C)OC1C(C)CC(C)C1OC(=O)CC2(O)CC=C(C)C(O2)/C(C)=C\CCCC(OC2CC(O)C(O)C(C)O2)/C=C\C(C)C(O)C1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9003,ML00006028,,,C/C=C/C1OC(O)(C(C)C(O)C(C)C2OC(=O)/C(OC)=C\C(C)=C/C(C)C(O)C(CC)C(O)C(C)C/C(C)=C\C=C/C2OC)CC(OC2CC(O)C(OC(N)=O)C(C)O2)C1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00006028_numbered.png,2026-03-19 06:58:51.231016
9004,ML00000749,CHEMBL1672598,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCc1cc(Br)c3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9005,ML00005802,,,CCC1C(O)C(C)/C=C(C)\C=C(\OC)C(=O)OC(C(C)C(O)C(C)C2(O)CC(OC3CC(O)C(OC(N)=O)C(C)O3)C(C)C(C)O2)C(OC)/C=C\C=C(\C)CC(C)C1O,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00005802_numbered.png,2026-03-19 06:58:51.304265
9006,ML00002621,,,CCC(=O)C1(C)OC1C(C)CC(C)C1OC(=O)CC2(O)CC=C(C)C(O2)/C(C)=C\CCCC(OC2CC(OC(N)=O)C(O)C(C)O2)/C=C\C(C)C(O)C1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9007,ML00007676,,,CS[C@H](C[C@@H]1C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)CC(=O)O1)C(=O)O,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00007676_numbered.png,2026-03-19 06:58:51.365064
9008,ML00007261,,,C/C1=C\[C@@H](C)C[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@H](Cc2ccc(O)c(Br)c2)N(C)C(=O)CNC(=O)[C@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9009,ML00007826,,,O=C1CCCCCCCCCCCCCCCCO1,standard_macrolactone,18.0,,,success,,0.0,[],ring_size_18/standard/numbered/ML00007826_numbered.png,2026-03-19 06:58:51.394140
9010,ML00002077,CHEMBL1700347,,CC1=CC2OC3CC4OC(=O)C=CC=CC(=O)OCCC(C)C(O)C(=O)OCC2(CC1O)C4(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9011,ML00000661,CHEMBL1604807,,CO[C@@H]1COC(=O)C/C=C\[C@@H](C)[C@@H]2C=C[C@H](O)[C@@H](COC(=O)CCC[C@H]1C)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9012,ML00005609,,,C/C=C/C1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)C2OC(=O)/C(OC)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H]2OC)C[C@@H](OC2CC(O)C(OC(N)=O)C(C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00005609_numbered.png,2026-03-19 06:58:51.464091
9013,ML00001335,CHEMBL2426327,,CO[C@@H]1C(=O)O[C@H](C)[C@H](C)/C=C(\C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1ccc(CO)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9014,ML00000341,CHEMBL2206972,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(NC4CCCCC4)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9015,ML00000668,CHEMBL1434146,,CO[C@@H]1COC(=O)[C@@H](CCSC)NC(=O)C/C=C\[C@@H](C)COC(=O)CCC[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9016,ML00010087,,,C=C1CC(=O)/C=C/C[C@@H]([C@@H](O)/C=C/[C@@H]2CC(C)=CCO2)OC(=O)/C=C\C[C@@H]2C=CC[C@@H](C[C@@H](C)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9017,ML00010088,,,C[C@H](O)[C@H]1/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@H]5C[C@@]5(C)CC[C@]4(COC(=O)[C@H]4O[C@]4(C)[C@@H](O)CO1)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9018,ML00009826,,,CC[C@H](C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H]([C@H](C)CC)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9019,ML00009829,,,CCC(C)C1C(=O)OC(C(C)C)C(=O)N(C)C(C(C)CC)C(=O)OC(C(C)C)C(=O)N(C)C(CC(C)C)C(=O)OC(C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9020,ML00001359,CHEMBL2426322,,CO[C@@H]1C(=O)O[C@H](C)[C@H](C)/C=C(\C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1ccccc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9021,ML00000694,CHEMBL1672605,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCc1cc(OC(F)(F)F)c3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9022,ML00002261,,,C=C(C)CCOc1ccc(C[C@@H]2NC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@H](C)NC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3ccccc3)OC(=O)[C@H](C)N(C)C2=O)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9023,ML00002260,,,CC[C@H](C)[C@H]1C(=O)N[C@@H](Cc2ccc(OCC=C(C)C)cc2)C(=O)N(C)[C@@H](C)C(=O)O[C@H](Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9024,ML00000295,CHEMBL2206983,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1ccc3c(c1)c(cc1nccn13)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9025,ML00010061,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/C(C(C)O)OCC(O)C(C)CC(=O)OC[C@@]2(C[C@@H]1O)[C@]4(C)[C@@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9026,ML00002850,,,CCC/C=C/C=C/C=C/[C@H]1C[C@@H]2/C=C\C=C/C=C\CC(=O)O[C@@]34C[C@@H](C)[C@@]5(O)[C@@H](C=C(CO)C[C@]6(O)C(=O)C(C)=C[C@H]65)[C@@H]3[C@@]4(C)COC(=O)/C=C\[C@H]21,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9027,ML00010388,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@@H]([C@H](C)O)OCC/C(C)=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9028,ML00010303,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](Cc2ccc(O)c(I)c2)N(C)C(=O)CNC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9029,ML00011032,,,CC(C)C[C@@H]1OC(=O)[C@H](C)NC(=O)[C@H](C(C)(C)O)OC(=O)[C@H](C)N(C)C(=O)[C@@H](C)NC(=O)[C@@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9030,ML00001360,CHEMBL2426319,,CO[C@@H]1C(=O)O[C@H](C)[C@H](C)/C=C(\C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1ccc(O)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9031,ML00009938,,,C/C1=C/C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)C[C@H](C)CCC1,standard_macrolactone,18.0,,,success,,9.0,"[3, 6, 10, 12, 13, 14, 15, 16, 17]",ring_size_18/standard/numbered/ML00009938_numbered.png,2026-03-19 06:58:51.644033
9032,ML00006464,,,O=C1OC[C@H]2OC(O)[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]3[C@@H]2OC(=O)c2cc(O)c(O)c(O)c2-c2c(O)c(O)c3oc(=O)c4cc(O)c(c5oc(=O)c2c3c54)Oc2c1cc(O)c(O)c2O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9033,ML00001425,CHEMBL2426328,,CO[C@@H]1C(=O)O[C@H](C)[C@H](C)/C=C(\C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1ccc(CCO)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9034,ML00010005,,,C[C@@H]1CCO[C@@H]([C@@H](C)O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5O[C@]5(C)CC[C@]4(COC(=O)[C@H]1O)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9035,ML00000053,CHEMBL334648,RORIDIN A,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\[C@H]([C@@H](C)O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9036,ML00009822,,,CC[C@H](C)[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]([C@@H](C)CC)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]([C@@H](C)CC)OC(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9037,ML00009034,,,C/C=C(C)/C=C(\C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H]1OC(=O)/C(CCCCCC)=C\c2csc(n2)[C@@H](C)[C@@H](O)C[C@H](O)/C=C\C=C/C[C@H]1O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9038,ML00007186,,,C=C1C[C@H](O)[C@@H]2O[C@@H]2[C@@H]2CC(=C)[C@H](CC[C@H](C/C=C/C)OC(=O)[C@H](C)C[C@@H](C)/C=C\1C)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9039,ML00000677,CHEMBL1672601,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCc1cc(CC)c3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9040,ML00010232,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)O)CCCCC(C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010232_numbered.png,2026-03-19 06:58:51.749687
9041,ML00004357,,,CC1NC(=O)C(NC(=O)c2cnc3ccccc3n2)COC(=O)C(C(C)C)N(C)C(=O)C2CSSCC(C(=O)N(C)C(C(C)C)C(=O)OCC(NC(=O)c3cnc4ccccc4n3)C(=O)NC(C)C(=O)N2C)N(C)C1=O,non_standard_macrocycle,18.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
9042,ML00001669,CHEMBL2426326,,CO[C@@H]1C(=O)O[C@H](C)[C@H](C)/C=C(\C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1ccc([N+](=O)[O-])cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9043,ML00010407,,,CC1=CC2OC3CC4OC(=O)C=CC=CC(C(C)O)OCC(O)C5(C)OC5C(=O)OCC2(CC1O)C4(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9044,ML00004101,,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C1[C@]14OC(=O)C5=C1C[C@H]1[C@](O)(COC(=O)/C(C)=C\COC(=O)CCC(=O)OC5)[C@H]5C[C@H]5[C@]1(C)[C@@H]4C[C@]3(O)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9045,ML00003936,,,CCC(=O)[C@H](C)[C@H](O)[C@H](C)C[C@H](C)[C@@H]1OC(=O)C[C@]2(O)CC=C(C)[C@H](O2)/C(C)=C\CCC[C@H](O[C@H]2C[C@@H](O)[C@H](O)[C@@H](C)O2)/C=C\[C@@H](C)C[C@@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9046,ML00010340,,,C/C(=C\c1csc(C)n1)[C@@H]1C/C=C\CCCCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,18.0,,,success,,8.0,"[3, 12, 13, 14, 15, 16, 16, 17]",ring_size_18/standard/numbered/ML00010340_numbered.png,2026-03-19 06:58:51.839353
9047,ML00008905,,,CC[C@H](C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9048,ML00001350,CHEMBL348867,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@@H]3CC(C)=CCO3)C[C@@H]3O[C@H]3[C@H](OC(=O)c3ccc([N+](=O)[O-])cc3)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9049,ML00010371,,,C=C1C[C@@H]2/C=C(/C)C[C@H]([C@H](O)NC(=O)/C=C\C=C\C)OC(=O)/C=C\C=C(\C)CC(=O)/C=C\C[C@H](C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9050,ML00006120,,,C/C=C\[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@@H](CC)[C@@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H]2OC)C[C@@H](OC(=O)/C=C/C(=O)NC2=C(O)CCC2=O)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00006120_numbered.png,2026-03-19 06:58:51.927503
9051,ML00008902,,,CC(C)C[C@H]1C(=O)O[C@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC(C)C)C(=O)O[C@H](CC(C)C)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9052,ML00010693,,,CCCCC/C=C/C(C)=C/[C@@H]1C[C@H](C)C/C=C\CC[C@@H](O)[C@H](OC(N)=O)CC[C@@H](C)C[C@H](OC(N)=O)[C@H](C)C(=O)O1,standard_macrolactone,18.0,,,success,,7.0,"[3, 5, 11, 12, 15, 17, 18]",ring_size_18/standard/numbered/ML00010693_numbered.png,2026-03-19 06:58:51.986007
9053,ML00008812,,,C/C1=C/C(C)CC(C)OC(=O)C(C)NC(=O)C(Cc2ccc(O)c(I)c2)N(C)C(=O)C(C)NC(=O)C(C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9054,ML00000335,CHEMBL2206964,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(-c4ccc(OC)cc4)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9055,ML00010453,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\C5OC(OC5C)C(O)/C(C)=C/C(=O)OC[C@@]2(CC1)[C@]4(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9056,ML00001020,CHEMBL1473901,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@H]2CCC[C@H]2C(=O)O)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00001020_numbered.png,2026-03-19 06:58:52.064844
9057,ML00010131,,,C[C@@H]1CCO[C@@H]([C@@H](C)O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5C[C@]5(CO)CC[C@]4(COC(=O)[C@H]1O)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9058,ML00000464,CHEMBL2206958,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(nc4cc(C)ccc4c3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9059,ML00008960,,,CC[C@H](C)[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]([C@](C)(O)CC)OC(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9060,ML00009439,,,CO[C@@H]1C(=O)O[C@H](C)[C@H](C)/C=C(\C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1ccc(C(N)=O)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9061,ML00010901,,,C/C=C\[C@@H](C)[C@H]1O[C@@H]1[C@H](O)[C@]1(O)COC(=O)C[C@@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)/C(C)=C\[C@@H](C)[C@H](O)C[C@@H](O)[C@H](C)C1=O,standard_macrolactone,18.0,,,success,,14.0,"[4, 4, 5, 6, 7, 9, 10, 12, 13, 14, 15, 16, 16, 17]",ring_size_18/standard/numbered/ML00010901_numbered.png,2026-03-19 06:58:52.175908
9062,ML00000169,CHEMBL1337128,,CO[C@@H]1COC(=O)C/C=C\[C@@H](C)COC(=O)[C@H](Cc2ccccc2)NC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9063,ML00008892,,,CC[C@H](C)[C@H]1NC(=O)[C@H](C(C)C)OC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)OC(=O)[C@@H](CC(C)C)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9064,ML00010007,,,CC1=CC2OC3CC4OC(=O)/C=C\C=C\C(C(C)O)OCC(O)C(C)CC(=O)OCC2(CC1O)C4(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9065,ML00009204,,,CC(C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9066,ML00000454,CHEMBL2206957,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(nc4ccc(Cl)cc4c3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9067,ML00007209,,,C=C1C[C@H](O)[C@@H]2O[C@H]2[C@@H]2CC(=C)[C@H](CC[C@H](C/C=C/C)OC(=O)[C@@H](C)C[C@@H](C)/C=C\1C)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9068,ML00010466,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OC[C@H](O)/C(C)=C\C(=O)OC[C@]2(CC1=O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9069,ML00004252,,,CC[C@H](C)[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]([C@@H](C)CC)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]([C@@H](C)CC)OC(=O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9070,ML00007240,,,C/C1=C/CC(=O)OC[C@]23CCC(CO)=C[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C/C(=O)OC1)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9071,ML00010703,,,CC[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9072,ML00009879,,,COC[C@@H]1NC(=O)[C@@H]2CCCNN2C(=O)[C@H](C(C)C)OC(=O)[C@@H](C2(C)CC2)NC(=O)[C@@H]2C[C@@]3(O)c4ccc(Cl)c(Cl)c4N[C@H]3N2C(=O)[C@@H]([C@H](O)CC(=O)O)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9073,ML00010042,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)C=CC=C[C@H]([C@@H](C)O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(CC1)[C@]4(C)[C@@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9074,ML00000141,CHEMBL2063085,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCC/C=C/c1nc3ccccc3cc1O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9075,ML00010011,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\[C@H]([C@H](C)O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9076,ML00010022,,,CC1=C[C@H]2O[C@@H]3[C@H](O)[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OCC/C(C)=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9077,ML00000708,CHEMBL1672592,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1Cc3ccccc3C1)NC(=O)OCCC/C=C/c1ccc3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9078,ML00000492,CHEMBL2204317,,COc1cc2nc(-c3ccccc3)cc3c2cc1/C=C/CC(C)(C)COC(=O)N[C@H]1CCCCC/C=C\[C@@H]2C[C@@]2(C(=O)NS(=O)(=O)C2CC2)NC(=O)[C@@H]2C[C@H](CN2C1=O)O3,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9079,ML00009037,,,CC(C)C[C@@H]1OC(=O)[C@H](C(C)C)OC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](Cc2ccccc2)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9080,ML00005997,,,CC(C)[C@@H]1OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9081,ML00008953,,,CC[C@H](C)[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]([C@](C)(O)CC)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9082,ML00002622,,,CCC(=O)[C@]1(C)O[C@@H]1[C@H](C)C[C@H](C)[C@@H]1OC(=O)C[C@]2(O)CC=C(C)[C@H](O2)/C(C)=C\CCC[C@H](O[C@H]2C[C@@H](OC(N)=O)[C@H](O)[C@@H](C)O2)/C=C\[C@@H](C)[C@@H](O)[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9083,ML00006485,,,CC[C@@H](C)[C@H]1OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]([C@H](C)CC)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]([C@H](C)CC)OC(=O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9084,ML00009844,,,CC(C)C[C@H]1C(=O)O[C@H](CC2CCCCC2)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9085,ML00003964,,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@@H]2C3=C1[C@]14OC(=O)C5=C1C[C@H]1[C@](O)(COC(=O)/C(C)=C\COC(=O)[C@@H](OC(C)=O)CC(=O)OC5)[C@H]5C[C@H]5[C@]1(C)[C@@H]4C[C@]3(O)[C@H]1C[C@@H]21,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9086,ML00010475,,,C/C1=C\C(=O)OC[C@]23CC[C@@]4(C)O[C@H]4[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C\C4OC(OC4C)C1O)[C@@]3(C)C21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9087,ML00010002,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC[C@@H](C)[C@@H](O)C(=O)OC[C@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9088,ML00009205,,,CC(C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9089,ML00007181,,,C[C@H]1C[C@H](C)C[C@@H](C)C[C@@H](C)[C@@H](O)/C(C#N)=C\C=C/C[C@H]([C@H]2C[C@@]2(C)C(=O)O)OC(=O)C[C@@H]1O,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00007181_numbered.png,2026-03-19 06:58:52.450874
9090,ML00008908,,,CC[C@@](C)(O)[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9091,ML00009290,,,C/C=C\C/C(C)=C/[C@H]1C/C=C\C=C/C[C@H](C)/C=C(/C)[C@@H](OC)C/C=C\[C@@H](O[C@@H]2O[C@H](OC)[C@@H](O)[C@H](OC)[C@H]2O)CC(=O)O1,standard_macrolactone,18.0,,,success,,5.0,"[3, 10, 12, 13, 17]",ring_size_18/standard/numbered/ML00009290_numbered.png,2026-03-19 06:58:52.506074
9092,ML00002539,,,CC(C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9093,ML00010001,,,CC1=CC2OC3CC4OC(=O)/C=C\C=C/C(C(C)O)OCCC(C)C(O)C(=O)OCC2(CC1O)C4(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9094,ML00010849,,,C=C1C[C@@H]2C/C=C/[C@H](O)[C@H](C)/C(C)=C\C(=O)O[C@H](CCC(C)C(C)O)[C@@H](C)C/C=C/[C@@](C)(O)[C@](O)(C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9095,ML00002259,,,CC[C@H](C)[C@H]1C(=O)N[C@@H](Cc2ccc(OCC=C(C)C)cc2)C(=O)N(C)[C@@H](C)C(=O)O[C@H](Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CO)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9096,ML00004132,,,CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@](C)(C(=O)[C@H](O)C1=C(C)C3C[C@@](O)([C@H](C)OC(=O)CCCCCCC(=O)N[C@@H](c4ccccc4)[C@@H](O)C(=O)O3)C1(C)C)C2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9097,ML00009476,,,COC[C@@H]1NC(=O)[C@@H]2C[C@@H](O)C=NN2C(=O)[C@H](C(C)(C)C)OC(=O)[C@@H](C2(C)CC2)NC(=O)[C@@H]2C[C@@]3(O)c4ccc(Cl)c(Cl)c4N[C@H]3N2C(=O)[C@@H]([C@H](O)CC(=O)O)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9098,ML00010403,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OC[C@@H](O)[C@@]5(C)O[C@@H]5C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9099,ML00000678,CHEMBL1672608,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCCCCCc1cc3c(nccc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9100,ML00010795,,,CC(=O)O[C@H]1C[C@@]23COC(=O)/C=C(/C)C[C@@H]4O[C@@H](C)[C@H](/C=C\C=C/C(=O)O[C@@H]5C[C@@H](O[C@@H]2C=C1C)[C@@]1(CO1)[C@]53C)O4,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9101,ML00009437,,,COC[C@@H]1NC(=O)[C@@H]2C[C@@H](Cl)CNN2C(=O)[C@H](C(C)(C)C)OC(=O)[C@@H](C2(C)CC2)NC(=O)[C@@H]2C[C@@]3(O)c4ccc(Cl)c(Cl)c4N[C@H]3N2C(=O)[C@@H]([C@H](O)CC(=O)O)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9102,ML00000952,CHEMBL251461,BEAUVERICIN H1,CC(C)[C@H]1OC(=O)[C@H](Cc2cccc(F)c2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9103,ML00001117,CHEMBL2063077,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCC/C=C/c1cccnc1O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9104,ML00009981,,,C=C1C[C@@H]2C/C=C\[C@@H](O)[C@@H](C)/C(C)=C\C(=O)O[C@H](C[C@@H](C)[C@H](C)O)[C@H](C)C/C=C\[C@](C)(O)[C@](O)(C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9105,ML00000774,CHEMBL1077073,SARCANDROLIDE C,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C(C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C(C)=C/COC(=O)[C@@H](OC(C)=O)CC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@H]31)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9106,ML00010338,,,CC1CC(C)CC(C)C(O)/C(C#N)=C\C=C\CC(C2CCCC2C(=O)O)OC(=O)CC(O)C(C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010338_numbered.png,2026-03-19 06:58:52.679395
9107,ML00000740,CHEMBL1672590,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCCC/C=C/c1ccc3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9108,ML00008890,,,CC[C@H](C)[C@H]1NC(=O)[C@@H](C(C)C)OC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)OC(=O)[C@@H](CC(C)C)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9109,ML00010467,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OC[C@H](O)/C(C)=C\C(=O)OC[C@@]2(CC1=O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9110,ML00010536,,,CC(=O)O[C@H]1CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)O)C/C=C/C=C(/C#N)[C@H](OC(C)=O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@@H]1C,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010536_numbered.png,2026-03-19 06:58:52.761730
9111,ML00010918,,,CCCOC(=O)[C@@H]1CCC[C@H]1[C@@H]1C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010918_numbered.png,2026-03-19 06:58:52.817436
9112,ML00009289,,,C/C=C\C/C(C)=C\[C@H]1C/C=C\C=C/C[C@H](C)/C=C(/C)[C@@H](OC)C/C=C\[C@@H](O[C@@H]2O[C@H](OC)[C@@H](O)[C@H](OC)[C@H]2O)CC(=O)O1,standard_macrolactone,18.0,,,success,,5.0,"[3, 10, 12, 13, 17]",ring_size_18/standard/numbered/ML00009289_numbered.png,2026-03-19 06:58:52.862393
9113,ML00009282,,,CC[C@H](C)[C@H](NC(=O)[C@@H]1CCC[C@H]1[C@@H]1C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)CC(=O)O1)C(=O)O,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00009282_numbered.png,2026-03-19 06:58:52.917567
9114,ML00000069,CHEMBL341800,"(6'R,13'S) ISORORIDIN A",CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\[C@H]([C@H](C)O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9115,ML00007232,,,CC1CCOC(=O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@H]5O[C@@]5(C)CC[C@]4(COC(=O)C1O)[C@]2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9116,ML00000340,CHEMBL1241239,CONCANAMYCIN A,C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](CC)[C@@H](O)[C@H](C)C/C(C)=C/C=C/[C@@H]2OC)C[C@@H](O[C@H]2C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00000340_numbered.png,2026-03-19 06:58:52.999650
9117,ML00000336,CHEMBL2206966,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(-c4ccccc4OC)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9118,ML00002460,,,CCC1C(O)C(C)/C=C(C)\C=C(\OC)C(=O)OC(C(C)C(O)C(C)C2(O)CC(OC(=O)/C=C/C(=O)O)C(C)C(C)O2)C(OC)/C=C\C=C(\C)CC(C)C1O,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00002460_numbered.png,2026-03-19 06:58:53.072543
9119,ML00010393,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC[C@@]5(C)O[C@@H]5C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9120,ML00010049,,,C[C@@H]1CCO[C@@H]([C@@H](C)O)/C=C\C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5O[C@]5(CO)CC[C@]4(COC(=O)[C@H]1O)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9121,ML00010370,,,C=C1C[C@H]2/C=C(/C)C[C@@H]([C@H](O)NC(=O)/C=C\C=C\C)OC(=O)/C=C\C=C(\C)CC(=O)/C=C\C[C@@H](C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9122,ML00002543,,,COC/C=C/C(C)=C1\CO[C@H](CC(C)C)\C1=C/[C@@H]1N=C2O[C@H]1COC(=O)[C@@H](CC(C)C)CC(=O)O[C@H]1[C@H](OC(=O)[C@]1(C)CO)/C(C)=C\Cc1ccc2[nH]1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9123,ML00009828,,,CCC(C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)CC)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)CC)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9124,ML00009878,,,COC[C@@H]1NC(=O)[C@@H]2CCCNN2C(=O)[C@H](C(C)C)OC(=O)[C@@H](C2(C)CC2)NC(=O)[C@@H]2C[C@@]3(O)c4ccc(Cl)c(Cl)c4N[C@H]3N2C(=O)[C@@H]([C@@H](O)CC(=O)O)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9125,ML00002540,,,CC(C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9126,ML00009949,,,C=C1CCC[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/C3CCCCC3)C/C=C/[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9127,ML00010531,,,C/C=C\[C@H](C)[C@H]1O[C@]1(C)[C@@H](O)[C@H]1COC(=O)[C@H](O)[C@@H](OC)[C@H](C)C(=O)[C@H](C)[C@@H](O)/C(C)=C\[C@H](C)C(=O)CC[C@H](C)C1=O,standard_macrolactone,18.0,,,success,,12.0,"[4, 5, 6, 9, 10, 12, 13, 14, 15, 16, 17, 18]",ring_size_18/standard/numbered/ML00010531_numbered.png,2026-03-19 06:58:53.202926
9128,ML00004189,,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C(C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C=C(/C)COC(=O)CCC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@H]31)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9129,ML00007241,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/C(=O)OCC/C(C)=C\C(=O)OC[C@@]2(C[C@@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9130,ML00010752,,,CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)OC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C(C)C)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9131,ML00000106,CHEMBL335838,,CC1=C[C@H]2O[C@@H]3[C@H](O)[C@H]4OC(=O)/C=C\C=C\[C@H]([C@@H](C)O)OCC/C(C)=C/C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9132,ML00000046,CHEMBL1450553,,CO[C@H]1COC(=O)C/C=C\[C@@H](C)COC(=O)[C@@H](CCSC)NC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9133,ML00007214,,,C[C@@H]1CCOC(=O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4C=C(CO)CC[C@]4(COC(=O)[C@H]1O)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9134,ML00004188,,,COC(=O)/C(C)=C1/C(=O)[C@H](O)[C@]2(C)C3=C(C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C(C)=C\COC(=O)CCC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@H]31)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9135,ML00009825,,,CC[C@H](C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H]([C@H](C)CC)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H]([C@H](C)CC)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9136,ML00007442,,,CC(=O)O[C@H](C)[C@H]1C(=O)N2C3=C(S[C@@H]4CN[C@@H](C4)C(=O)Nc4cccc(c4)C(=O)OCOCOC3=O)[C@H](C)[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9137,ML00008312,,,CO[C@H]1COC(=O)C/C=C\[C@H](C)COC(=O)[C@@H](C)NC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9138,ML00009214,,,CC(C)C[C@@H]1C(=O)N2C[C@@H](C)C[C@@H]2C(=O)N[C@H](C(C)C)C(=O)O[C@@H](C(C)C)C(=O)N2NCCC[C@H]2C(=O)N2NC[C@@H](O)C[C@H]2C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9139,ML00008143,,,O=C1CC/C=C\C=C/CCCCOC(=O)CCCCO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9140,ML00007326,,,C/C1=C\C(=O)OC[C@]23CC[C@]4(C)C[C@H]4[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C\C(=O)OCC1)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9141,ML00007222,,,C[C@@H]1CCOC(=O)/C=C\C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@H]5O[C@@]5(CO)CC[C@]4(COC(=O)[C@H]1O)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9142,ML00006795,,,CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9143,ML00010339,,,CC1CC(C)CC(C)C(O)/C(C#N)=C/C=C/CC(C2CCCC2C(=O)O)OC(=O)CC(O)C(C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010339_numbered.png,2026-03-19 06:58:53.373119
9144,ML00000059,CHEMBL136268,RORIDIN L,CC1=C[C@H]2O[C@@H]3[C@H](O)[C@H]4OC(=O)/C=C\C=C\[C@H]([C@H](C)O)OCC/C(C)=C/C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9145,ML00004139,,,C/C1=C/Cc2ccc([nH]2)C2=N[C@@H](/C=C3C(=C(\C)CCCO)/CO[C@H]/3CC(C)C)[C@H](COC(=O)/C(CC(C)C)=C\C(=O)O[C@H]3[C@@H]1OC(=O)[C@]3(C)CO)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9146,ML00000150,CHEMBL2206970,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(N(C)C(=O)OCC)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9147,ML00003937,,,CCC(=O)[C@@H](C)[C@@H](O)[C@H](C)C[C@@H](C)[C@H]1OC(=O)C[C@@]2(O)CC=C(C)[C@H](O2)/C(C)=C\CCC[C@@H](O[C@@H]2C[C@@H](O)[C@H](O)[C@H](C)O2)/C=C\[C@H](C)C[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9148,ML00009911,,,CC[C@H](C)[C@@H]1OC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)c2cccc(N)c2O)[C@@H](C)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)C(=O)[C@H](CC(C)C)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9149,ML00010376,,,C[C@H](O)[C@H]1/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5O[C@]5(C)CC[C@]4(COC(=O)[C@H]4O[C@]4(C)[C@@H](O)CO1)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9150,ML00010987,,,C=C1CC(=N\OC)/C=C/C[C@@H]([C@@H](O)/C=C/[C@@H]2CC(C)=CCO2)OC(=O)/C=C\C[C@@H]2C=CC[C@@H](C[C@@H](C)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9151,ML00010991,,,CC(=O)OC1(C)CC(=O)OCC23CCC(C)=CC2OC2CC(OC(=O)/C=C\C=C\C(C(C)O)OCC1O)C3(C)C21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9152,ML00007216,,,C[C@@H]1CCOC(=O)/C=C\C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4C=C(CO)CC[C@]4(COC(=O)[C@H]1O)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9153,ML00010349,,,CC1=C[C@H]2O[C@@H]3[C@H](O)[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OCC[C@@]5(C)O[C@@H]5C(=O)OC[C@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9154,ML00003375,,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@H]2[C@@H]3C[C@@H]3C3=C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C(C)=C\COC(=O)[C@@H](O)CC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@@H]1[C@]32OO,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9155,ML00004104,,,CO[C@]12OC(=O)C(C)=C1C1=C3[C@](O)(C[C@H]4[C@@]5(C)[C@@H]6C[C@@H]6[C@@]6(O)COC(=O)/C(C)=C\COC(=O)CCC(=O)OCC7=C(C[C@@H]65)[C@@]14OC7=O)[C@H]1C[C@H]1[C@]3(C)[C@H]2O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9156,ML00000785,CHEMBL398305,BEAUVERICIN G3,CC[C@H]1OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](CC)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](CC)OC(=O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9157,ML00009950,,,CC1=CC2O[C@@H]3C[C@H]4OC(=O)CCCCC(C(C)O)OCC(O)C5(C)OC5C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9158,ML00007244,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\C(=O)OCC/C(C)=C/C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9159,ML00009401,,,COC[C@@H]1NC(=O)[C@@H]2C[C@H](Cl)CNN2C(=O)[C@H](C(C)(C)C)OC(=O)[C@@H](C2(C)CC2)NC(=O)[C@@H]2C[C@@]3(O)c4ccc(Cl)c(Cl)c4N[C@H]3N2C(=O)[C@@H]([C@H](O)CC(=O)O)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9160,ML00005607,,,C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)[C@H](C)C/C(C)=C\C=C/[C@H]2OC)C[C@@H](O[C@H]2C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00005607_numbered.png,2026-03-19 06:58:53.574749
9161,ML00002679,,,CCC(=O)[C@@H](C)[C@@H](O)[C@H](C)C[C@H](C)[C@H]1OC(=O)C[C@]2(O)CC=C(C)[C@H](O2)/C(C)=C\CCC[C@@H](O[C@@H]2C[C@@H](OC(N)=O)[C@H](O)[C@@H](C)O2)/C=C\[C@@H](C)C[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9162,ML00010262,,,Cc1c2cc3c(c1O)C(=O)C[C@H](O3)c1ccc(O)c(c1)-c1cccc(c1O)C(=O)OC[C@H]1O[C@@H](O2)[C@H](O)[C@H](O)[C@@H]1O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9163,ML00010051,,,CC(O)C1/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4C[C@@H](C)[C@H](O)C[C@]4(COC(=O)C4OC4(C)C(O)CO1)[C@]2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9164,ML00001943,CHEMBL155531,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@H](/C=C/[C@@H]3CC(C)=CCO3)OC(C)=O)C[C@@H]3O[C@H]3[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9165,ML00000680,CHEMBL2063082,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCC/C=C/c1cc3ccccc3nc1O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9166,ML00008965,,,CC[C@H](C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@H]([C@H](C)CC)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9167,ML00009291,,,C/C=C/C/C(C)=C\[C@H]1C/C=C\C=C/C[C@H](C)/C=C(/C)[C@@H](OC)C/C=C\[C@@H](O[C@@H]2O[C@H](OC)[C@@H](O)[C@H](OC)[C@H]2O)CC(=O)O1,standard_macrolactone,18.0,,,success,,5.0,"[3, 10, 12, 13, 17]",ring_size_18/standard/numbered/ML00009291_numbered.png,2026-03-19 06:58:53.667565
9168,ML00005594,,,C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@@H](CC)[C@@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H]2OC)C[C@@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00005594_numbered.png,2026-03-19 06:58:53.725267
9169,ML00000649,CHEMBL1316072,,CO[C@@H]1COC(=O)C/C=C/[C@@H](C)[C@@H]2C=C[C@H](O)[C@@H](COC(=O)C/C=C\[C@H]1C)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9170,ML00009413,,,CCC(C)[C@@H]1OC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)C(=O)[C@H](CC(C)C)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9171,ML00002683,,,CCC(=O)[C@@H](C)[C@@H](O)[C@H](C)C[C@@H](C)[C@H]1OC(=O)C[C@@]2(O)CC=C(C)[C@H](O2)/C(C)=C\CCC[C@@H](O[C@@H]2C[C@@H](OC(N)=O)[C@H](O)[C@@H](C)O2)/C=C\[C@H](C)C[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9172,ML00004875,,,CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@H]([C@@H](C)O)OC2=O)O[C@@H]1C,standard_macrolactone,18.0,,,success,,8.0,"[3, 6, 8, 9, 10, 12, 13, 18]",ring_size_18/standard/numbered/ML00004875_numbered.png,2026-03-19 06:58:53.806423
9173,ML00004103,,,CO[C@@]12OC(=O)C(C)=C1C1=C3[C@](O)(C[C@H]4[C@@]5(C)[C@@H]6C[C@@H]6[C@@]6(O)COC(=O)/C(C)=C\COC(=O)CCC(=O)OCC7=C(C[C@@H]65)[C@@]14OC7=O)[C@H]1C[C@H]1[C@]3(C)[C@H]2O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9174,ML00000739,CHEMBL1671868,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCc1cc(I)c3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9175,ML00010360,,,C/C1=C/C(=O)OC[C@@]23CC[C@@]4(C)O[C@H]4[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OC[C@@H]1O)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9176,ML00001162,CHEMBL347270,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@@H]3CC(C)=CCO3)C/C=C/[C@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9177,ML00001246,CHEMBL3809007,,CO[C@]12OC(=O)C(C)=C1C1=C3[C@](O)(C[C@H]4[C@@]5(C)[C@@H]6C[C@@H]6[C@@]6(O)COC(=O)/C(C)=C/COC(=O)CCC(=O)OCC7=C(C[C@@H]65)[C@@]14OC7=O)[C@H]1C[C@H]1[C@]3(C)[C@H]2O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9178,ML00010335,,,C[C@@H]1C[C@H](C)[C@@H](O)/C(C#N)=C\C=C/C[C@H]([C@@H]2CCC[C@@H]2C(=O)O)OC(=O)C[C@@H](O)[C@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010335_numbered.png,2026-03-19 06:58:53.893613
9179,ML00005705,,,CC[C@@H](C)[C@H]1OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9180,ML00004105,,,CO[C@@]12OC(=O)C(C)=C1C1=C3[C@](O)(C[C@H]4[C@@]5(C)[C@@H]6C[C@@H]6[C@@]6(O)COC(=O)/C(C)=C/COC(=O)CCC(=O)OCC7=C(C[C@@H]65)[C@@]14OC7=O)[C@H]1C[C@H]1[C@]3(C)[C@H]2O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9181,ML00000038,CHEMBL2203873,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(OCC)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9182,ML00011015,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00011015_numbered.png,2026-03-19 06:58:53.968863
9183,ML00010459,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\[C@H]5O[C@H](C/C(C)=C/C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)O[C@@H]5C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9184,ML00010389,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@@H]([C@H](C)O)OCC/C(C)=C\C(=O)OC[C@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9185,ML00009245,,,CC(C)C[C@@H]1OC(=O)[C@H](C(C)C)OC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](Cc2ccccc2)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9186,ML00005595,,,C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@@H](O)[C@@H](C)[C@H]2OC(=O)/C(OC)=C\C(C)=C/[C@H](C)[C@@H](O)[C@@H](CC)[C@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H]2OC)C[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@@H]2O)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00005595_numbered.png,2026-03-19 06:58:54.047810
9187,ML00010060,,,CC1=CC2OC3CC4OC(=O)/C=C\C=CC(C(C)O)OCC(O)C(C)CC(=O)OCC2(CC1O)C4(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9188,ML00001161,CHEMBL244368,FIJIANOLIDE G,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@@H]3C[C@@]4(C)O[C@H]4[C@@H](O)O3)C[C@@H]3O[C@H]3[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9189,ML00004081,,,CC(C)=CCOc1ccc(C[C@H]2NC(=O)[C@H](C)NC(=O)[C@@H](Cc3ccc(O)cc3)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)OC2=O)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9190,ML00009983,,,C=C1C[C@@H]2C/C=C/[C@H](O)[C@H](C)/C(C)=C\C(=O)O[C@H](C[C@H](C)[C@H](C)O)[C@@H](C)C/C=C/[C@@](C)(O)[C@](O)(C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9191,ML00008313,,,CO[C@H]1COC(=O)C/C=C\[C@@H](C)COC(=O)[C@@H](C)NC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9192,ML00009512,,,CO[C@@H]1C[C@H](CC[C@H](C)[C@H](O)[C@H](C)[C@@H]2OC(=O)/C(C)=C\C[C@H](O)C[C@@H]3C=CC[C@H](C[C@H](OC)[C@@H](C)[C@@H](O)C[C@@H](O)[C@@H]2C)O3)O[C@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9193,ML00005081,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C/C=C/C(=O)OCC[C@@H](C)[C@H](OC(=O)OCCSSC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CNC(=O)[C@H](Cc5ccccc5)NC(=O)[C@H](Cc5ccccc5)NC(=O)CCCCCCNC(=O)CC[C@H](NC(=O)N[C@H](CCC(=O)O)C(=O)O)C(=O)O)C(=O)O)C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9194,ML00006497,,,CSC[C@H]1C(=O)OC[C@@H](NC(=O)c2nc3ccccc3cc2O)C(=O)NCC(=O)N(C)[C@H]2CSSC[C@@H](C(=O)N1C)N(C)C(=O)CNC(=O)[C@H](NC(=O)c1nc3ccccc3cc1O)COC(=O)[C@H](CSC)N(C)C2=O,non_standard_macrocycle,18.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
9195,ML00010204,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OCC[C@]5(C)O[C@@H]5C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9196,ML00001664,CHEMBL1744501,,CC=C[C@H]1O[C@@](O)([C@@H](C)C(O)C(C)[C@H]2OC(=O)C(OC)=CC(C)=C[C@@H](C)[C@H](O)C(CC)[C@@H](O)[C@H](C)CC(C)=CC=C[C@@H]2OC)C[C@@H](O[C@H]2C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00001664_numbered.png,2026-03-19 06:58:54.196751
9197,ML00010004,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OC[C@H](O)[C@@H](C)CC(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9198,ML00009426,,,CC[C@@H](C)[C@H]1C(=O)O[C@H](Cc2ccc(N3CCOCC3)cc2)C(=O)N(C)[C@@H]([C@H](C)CC)C(=O)O[C@H](C)C(=O)N(C)[C@@H](C)C(=O)O[C@H](C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9199,ML00010455,,,CC1=C[C@H]2O[C@@H]3[C@H](O)[C@H]4OC(=O)/C=C\C=C/[C@@H]5O[C@H](C/C(C)=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)O[C@H]5C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9200,ML00010012,,,CC1=CC2OC3CC4OC(=O)/C=C\C=C\C(C(C)O)OCCC(C)C(O)C(=O)OCC2(CC1O)C4(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9201,ML00007266,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)CC/C=C\C(=O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9202,ML00004686,,,CC(C)[C@H]1C(=O)OC[C@@H](NC(=O)c2nc3ccccc3cc2O)C(=O)N[C@@H](C)C(=O)N(C)[C@H]2CSSC[C@@H](C(=O)N1C)N(C)C(=O)[C@H](C)NC(=O)[C@H](NC(=O)c1nc3ccccc3cc1O)COC(=O)[C@H](C(C)C)N(C)C2=O,non_standard_macrocycle,18.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
9203,ML00009993,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)c(I)c2)N(C)C(=O)CNC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9204,ML00006307,,,C/C=C/[C@H]1O[C@@](O)([C@@H](C)C(O)C(C)[C@H]2OC(=O)C(OC)=CC(C)=C[C@@H](C)[C@H](O)C(CC)[C@@H](O)[C@H](C)CC(C)=CC=C[C@@H]2OC)C[C@@H](O[C@H]2C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00006307_numbered.png,2026-03-19 06:58:54.332507
9205,ML00006406,,,C/C=C/[C@H]1O[C@@](OC)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)[C@H](C)C/C(C)=C/C=C/[C@@H]2OC)CC(OC2CC(O)C(OC(N)=O)C(C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00006406_numbered.png,2026-03-19 06:58:54.391896
9206,ML00010519,,,CC[C@H](C)/C=C/C=C/C[C@@H]1NC(=O)[C@H]2C[C@H](O)CNN2C(=O)COC(=O)[C@](C)(CO)NC(=O)[C@H]2C[C@@H](O)CNN2C(=O)[C@H]2C[C@H](Cl)CNN2C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9207,ML00000343,CHEMBL2206967,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(-c4ccc(F)cc4)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9208,ML00007225,,,CC1=C[C@H]2O[C@H]3C[C@H]4OC(=O)/C=C\C=C/C(=O)OCC[C@@H](C)C(O)C(=O)OC[C@@]2(CC1)[C@@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9209,ML00007270,,,CC1CCOC(=O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4C[C@@H](C)[C@@H](O)C[C@]4(COC(=O)C1O)[C@]2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9210,ML00009667,,,CO[C@@H]1C(=O)O[C@@H](C)[C@@H](C)/C=C(/C)C[C@@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Cl)[nH]c3ccccc23)C(=O)N[C@@H]1c1ccc(O)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9211,ML00004193,,,CO[C@]12OC(=O)C(C)=C1C1=C3C(=C[C@H]4[C@@]5(C)[C@@H]6C[C@@H]6[C@@]6(O)COC(=O)/C(C)=C\COC(=O)CCC(=O)OCC7=C(C[C@@H]65)[C@@]14OC7=O)[C@H]1C[C@H]1[C@]3(C)[C@H]2O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9212,ML00003327,,,CC1=C2[C@H](OC1=O)C(=O)[C@@]1(C)[C@@H]3C[C@@H]3C3=C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C=C(/C)COC(=O)CCC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@@H]2[C@]31O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9213,ML00011033,,,CC(C)C[C@@H]1OC(=O)[C@H](C)NC(=O)[C@H](C(C)C)OC(=O)[C@H](C)N(C)C(=O)[C@@H](C)NC(=O)[C@@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9214,ML00010350,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\C([C@@H](C)O)OC[C@H](O)[C@@]5(C)O[C@@H]5C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9215,ML00001000,CHEMBL4089044,,CC(C)C[C@@H]1NC(=O)OC(c2cccc(Cl)c2)CCCCCCNC(=O)CC[C@@H](C=O)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9216,ML00000490,CHEMBL2206968,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(-c4cccnc4)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9217,ML00010030,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](Cc2ccc(O)c(Br)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9218,ML00008904,,,CC[C@H](C)[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9219,ML00000849,CHEMBL1672595,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](c1c[nH]c3ccccc13)NC(=O)OCCC/C=C/c1ccc3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9220,ML00009268,,,C/C=C/C/C(C)=C\[C@H]1C/C=C\C=C/C[C@H](C)/C=C(/C)[C@@H](OC)C[C@@H](O)C[C@@H](O[C@@H]2O[C@H](OC)[C@@H](O)[C@H](OC)[C@H]2O)CC(=O)O1,standard_macrolactone,18.0,,,success,,6.0,"[3, 10, 12, 13, 15, 17]",ring_size_18/standard/numbered/ML00009268_numbered.png,2026-03-19 06:58:54.543735
9221,ML00010413,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@@H]([C@H](C)O)OCC/C(C)=C\C(=O)OC[C@@]2([C@H]2O[C@@H]12)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9222,ML00010010,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\[C@H]([C@H](C)O)OC[C@H](O)[C@@H](C)CC(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9223,ML00008966,,,CC[C@H](C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9224,ML00002544,,,COCCC/C(C)=C1\CO[C@H](CC(C)C)\C1=C/[C@@H]1N=C2O[C@H]1COC(=O)/C(CC(C)C)=C\C(=O)O[C@H]1[C@H](OC(=O)[C@]1(C)CO)/C(C)=C\Cc1ccc2[nH]1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9225,ML00006131,,,CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](O)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C,standard_macrolactone,18.0,,,success,,8.0,"[3, 6, 8, 9, 10, 12, 13, 18]",ring_size_18/standard/numbered/ML00006131_numbered.png,2026-03-19 06:58:54.631092
9226,ML00008877,,,C=C1CC(/C=C/c2csc(C)n2)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@@H]3CC(C)=CCO3)C[C@@H]3O[C@H]3[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9227,ML00009206,,,CC(C)C1OC(=O)C(C(C)C)N(C)C(=O)C(C(C)C)OC(=O)C(C(C)C)N(C)C(=O)C(C(C)C)OC(=O)C(C(C)C)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9228,ML00010855,,,C/C1=C/C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CC(C)CCC1,standard_macrolactone,18.0,,,success,,10.0,"[3, 6, 10, 12, 13, 14, 15, 16, 16, 17]",ring_size_18/standard/numbered/ML00010855_numbered.png,2026-03-19 06:58:54.698167
9229,ML00001868,CHEMBL1396867,,CO[C@H]1COC(=O)[C@H](C)NC(=O)[C@@H](C)COC(=O)[C@H]2CCCN2C(=O)C/C=C\[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9230,ML00001205,CHEMBL421999,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@H](/C=C/[C@@H]3CC(C)=CCO3)OC)C[C@@H]3O[C@H]3[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9231,ML00010117,,,C/C1=C/[C@@H](C)C[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)c(I)c2)N(C)C(=O)[C@H](C)NC(=O)[C@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9232,ML00010386,,,CC1=C[C@@H]2O[C@H]3C[C@@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC/C(C)=C\C(=O)OC[C@]2(CC1)[C@@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9233,ML00002680,,,CCC(=O)[C@@H](C)[C@@H](O)[C@H](C)C[C@H](C)[C@H]1OC(=O)C[C@@]2(O)CC=C(C)[C@@H](O2)/C(C)=C\CCC[C@@H](O[C@@H]2C[C@@H](OC(N)=O)[C@H](O)[C@@H](C)O2)/C=C\[C@@H](C)C[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9234,ML00009885,,,CO[C@@H]1C(=O)O[C@@H](C)[C@@H](C)/C=C(/C)C[C@@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H]1c1ccc(O)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9235,ML00000402,CHEMBL582439,ZAMPANOLIDE,C=C1C[C@H]2/C=C(\C)C[C@@H]([C@H](O)NC(=O)/C=C\C=C\C)OC(=O)/C=C/C=C(/C)CC(=O)/C=C/C[C@@H](C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9236,ML00010055,,,C[C@@H]1CCO[C@@H]([C@@H](C)O)/C=C\C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4C=C(CO)CC[C@]4(COC(=O)[C@H]1O)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9237,ML00011011,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)N[C@@H](CO)C(=O)O)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00011011_numbered.png,2026-03-19 06:58:54.798809
9238,ML00009177,,,CC[C@@H](C)[C@H]1C(=O)O[C@H](Cc2ccccc2)C(=O)N(C)[C@@H]([C@H](C)CC)C(=O)O[C@H](C)C(=O)N(C)[C@@H](C)C(=O)O[C@H](C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9239,ML00006690,,,COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OCCCCCCCCC(=O)N1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9240,ML00007229,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/C(=O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9241,ML00010529,,,C/C=C\[C@H](C)[C@H]1O[C@@]1(C)[C@@H](O)[C@H]1COC(=O)[C@H](O)[C@@H](OC)[C@H](C)C(=O)[C@H](C)[C@@H](O)/C(C)=C/[C@H](C)C(=O)CC[C@@H](C)C1=O,standard_macrolactone,18.0,,,success,,12.0,"[4, 5, 6, 9, 10, 12, 13, 14, 15, 16, 17, 18]",ring_size_18/standard/numbered/ML00010529_numbered.png,2026-03-19 06:58:54.881467
9242,ML00001580,CHEMBL2206962,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCC(C)(C)C/C=C/c1cc3c(cc(-c4ccccc4)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9243,ML00007269,,,CC1CCOC(=O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4C[C@@H](C)[C@H](O)C[C@]4(COC(=O)C1O)[C@]2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9244,ML00001523,CHEMBL2426325,,CO[C@@H]1C(=O)O[C@H](C)[C@H](C)/C=C(\C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1ccc(F)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9245,ML00007560,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/C(=O)OCC[C@@H](C)C(=O)C(=O)OC[C@@]2(CC1)[C@]4(C)[C@@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9246,ML00004195,,,COC(=O)[C@]1(C)C2=C(C3=C(C)C(=O)OC3=O)[C@]34OC(=O)C5=C3C[C@H]3[C@](O)(COC(=O)/C(C)=C\COC(=O)CCC(=O)OC5)[C@H]5C[C@H]5[C@]3(C)[C@@H]4C=C2[C@H]2C[C@H]21,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9247,ML00006659,,,C=C1C[C@@H]2/C=C(/C)C[C@H](C=O)OC(=O)/C=C\C=C(\C)CC(=O)/C=C\C[C@H](C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9248,ML00000142,CHEMBL2063086,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCCCc1nc3ccccc3cc1O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9249,ML00002516,,,COCCC/C(C)=C1\COC(CC(C)C)\C1=C/C1N=C2OC1COC(=O)[C@@H](CC(C)C)CC(=O)OC1C(OC(=O)C1(C)CO)/C(C)=C/Cc1ccc2[nH]1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9250,ML00010304,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](CO)NC(=O)[C@@H](Cc2ccc(O)c(I)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9251,ML00006408,,,C/C=C\[C@H]1O[C@@](O)([C@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@@H](CC)[C@@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H]2OC)C[C@@H](O[C@H]2C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00006408_numbered.png,2026-03-19 06:58:54.998225
9252,ML00007420,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\C(=O)OCC[C@@]5(C)O[C@@H]5C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9253,ML00010573,,,CC(C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9254,ML00000070,CHEMBL155405,FIJIANOLIDE B,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@@H]3CC(C)=CCO3)C[C@@H]3O[C@H]3[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9255,ML00007609,,,CC1=C[C@H]2O[C@@H]3[C@H](O)[C@H]4OC(=O)/C=C\C=C/C(=O)OCC/C(C)=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9256,ML00007610,,,CC1=C[C@H]2O[C@@H]3[C@H](O)[C@H]4OC(=O)/C=C\C=C/C(=O)OCC/C(C)=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9257,ML00006174,,,CC(C)[C@H]1C(=O)OC[C@@H](NC(=O)c2cnc3ccccc3n2)C(=O)N[C@@H](C)C(=O)N(C)[C@H]2CSSC[C@@H](C(=O)N1C)N(C)C(=O)[C@H](C)NC(=O)[C@H](NC(=O)c1cnc3ccccc3n1)COC(=O)[C@H](C(C)C)N(C)C2=O,non_standard_macrocycle,18.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
9258,ML00007230,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\C(=O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9259,ML00000186,CHEMBL2203324,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(nc4cc(OC)ccc4c3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9260,ML00010028,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\[C@H]([C@H](C)O)OC[C@H](O)[C@@H](C)CC(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9261,ML00002492,,,COC/C=C/C(C)=C1\CO[C@H](CC(C)C)\C1=C/[C@@H]1N=C2O[C@H]1COC(=O)/C(CC(C)C)=C\C(=O)O[C@H]1[C@H](OC(=O)[C@]1(C)CO)/C(C)=C\Cc1ccc2[nH]1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9262,ML00000319,CHEMBL2206978,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(OCc4csc(C)n4)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9263,ML00002538,,,CC(C)C[C@H]1NC(=O)[C@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9264,ML00004112,,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C(C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C(C)=C\COC(=O)[C@H](O)CC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@H]31)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9265,ML00006001,,,CC(C)[C@H]1OC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9266,ML00010920,,,CC(C)SC(=O)[C@@H]1CCC[C@H]1[C@@H]1C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010920_numbered.png,2026-03-19 06:58:55.147525
9267,ML00007683,,,CC(C)(C)c1cc(C2COC(=O)COCC(=O)OCCOCCOCCO2)cc(C(C)(C)C)c1O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9268,ML00009925,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccc(O)c(I)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9269,ML00004876,,,CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C,standard_macrolactone,18.0,,,success,,8.0,"[3, 6, 8, 9, 10, 12, 13, 18]",ring_size_18/standard/numbered/ML00004876_numbered.png,2026-03-19 06:58:55.215689
9270,ML00010046,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OC[C@H](O)[C@H](C)CC(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9271,ML00001944,CHEMBL348272,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@@H]3CC(C)=CCO3)C[C@@H]3O[C@H]3[C@H](OC(=O)OC)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9272,ML00001247,CHEMBL4104829,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C1[C@]14OC(=O)C5=C1C[C@H]1[C@](O)(COC(=O)/C=C(\C)COC(=O)CCC(=O)OC5)[C@H]5C[C@H]5[C@]1(C)[C@@H]4C[C@]3(OO)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9273,ML00008950,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)OCc2ccccc2)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00008950_numbered.png,2026-03-19 06:58:55.284093
9274,ML00009998,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\[C@H]([C@@H](C)O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9275,ML00007217,,,C[C@H](O)[C@H]1/C=C\C=C/C(=O)O[C@@H]2C[C@H]3O[C@H]4[C@@H]5O[C@]5(C)CC[C@]4(COC(=O)[C@H]4O[C@]4(C)[C@@H](O)CO1)[C@@H]2C3=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9276,ML00008813,,,C/C1=C/[C@@H](C)[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Cl)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9277,ML00005703,,,CC(C)C[C@@H]1OC(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9278,ML00001074,CHEMBL1592717,,CO[C@@H]1COC(=O)C/C=C/[C@@H](C)[C@@H]2C=C[C@@H](O)[C@@H](COC(=O)C/C=C\[C@H]1C)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9279,ML00010348,,,CC1=C[C@H]2O[C@@H]3[C@H](O)[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OCC[C@]5(C)O[C@@H]5C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9280,ML00002530,,,COCCC/C(C)=C1\CO[C@H](CC(C)C)\C1=C/[C@@H]1N=C2O[C@H]1COC(=O)[C@@H](CC(C)C)CC(=O)O[C@H]1[C@H](OC(=O)[C@]1(C)CO)/C(C)=C\Cc1ccc2[nH]1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9281,ML00007235,,,CC1CCOC(=O)C=CC=CC(=O)OC2CC3OC4C5OC5(C)CCC4(COC(=O)C1O)C2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9282,ML00009223,,,CO[C@H](C)[C@H](C)[C@H](O)[C@H](C)[C@H](O)CC[C@H](C)[C@@H]1C/C=C\C=C/C[C@@H](O)[C@H]2O[C@@H]2[C@H](O)[C@H](C)/C=C(C)\C=C(\C)C(=O)O1,standard_macrolactone,18.0,,,success,,6.0,"[3, 10, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00009223_numbered.png,2026-03-19 06:58:55.398740
9283,ML00000473,CHEMBL2206959,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(nc4cc(C#N)ccc4c3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9284,ML00010260,,,Cc1c2cc3c(c1O)C(=O)C[C@H](O3)c1ccc(O)c(c1)-c1cc(ccc1O)C(=O)OC[C@@H]1O[C@H](O2)[C@@H](O)[C@H](O)[C@@H]1O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9285,ML00003938,,,CCC(=O)[C@@H](C)[C@@H](O)[C@H](C)C[C@@H](C)[C@H]1OC(=O)C[C@@]2(O)CC=C(C)[C@H](O2)/C(C)=C\CCC[C@@H](O[C@H]2C[C@@H](O)[C@H](O)[C@@H](C)O2)/C=C\[C@H](C)C[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9286,ML00005597,,,C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@@H](CC)[C@@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H]2OC)C[C@@H](O[C@H]2C[C@@H](O)[C@H](O)[C@@H](C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00005597_numbered.png,2026-03-19 06:58:55.494370
9287,ML00000125,CHEMBL1672587,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCC/C=C/c1ccc3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9288,ML00001262,CHEMBL2204318,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCc1ccc3nc(-c4ccccc4)cc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9289,ML00006705,,,COC(=O)[C@@H]1CSCc2c(O)cc(OC)c(C)c2C(=O)OCCCCCCCC/C(S)=N/1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9290,ML00004187,,,COC(=O)/C(C)=C1\C(=O)[C@@H](O)[C@@]2(C)C3=C(C[C@H]4[C@@]5(OC(=O)C6=C5C[C@@H]5[C@@](O)(COC(=O)/C(C)=C\COC(=O)CCC(=O)OC6)[C@@H]6C[C@@H]6[C@]54C)[C@@H]31)[C@@H]1C[C@@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9291,ML00009866,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)OCc2cn(-c3cccnc3)nn2)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00009866_numbered.png,2026-03-19 06:58:55.590521
9292,ML00009163,,,CC[C@@H](C)[C@H]1C(=O)O[C@H](Cc2ccc(N)cc2)C(=O)N(C)[C@@H]([C@H](C)CC)C(=O)O[C@H](C)C(=O)N(C)[C@@H](C)C(=O)O[C@H](C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9293,ML00010029,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OC[C@H](O)[C@@H](C)CC(=O)OC[C@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9294,ML00009096,,,O=C1OC[C@H]2OC(O)[C@H](O)[C@@H](O)[C@@H]2OC(=O)c2cc(O)c(O)c(O)c2-c2c(O)c(O)c3oc(=O)c4cc(O)c(c5oc(=O)c2c3c54)Oc2c1cc(O)c(O)c2O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9295,ML00010853,,,CCOC(=O)[C@@H]1CCC[C@H]1[C@@H]1C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010853_numbered.png,2026-03-19 06:58:55.676591
9296,ML00002796,,,C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@H](O)[C@@H](CC)[C@@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H]2OC)C[C@H](OC(=O)/C=C/C(=O)O)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00002796_numbered.png,2026-03-19 06:58:55.744979
9297,ML00001118,CHEMBL2063083,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCC/C=C/c1ncccc1O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9298,ML00010392,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC[C@@]5(C)O[C@@H]5C(=O)OC[C@@]2(CC1)[C@]4(C)[C@@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9299,ML00010402,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@@H]([C@H](C)O)OC[C@@H](O)[C@]5(C)O[C@@H]5C(=O)OC[C@]2(C[C@H]1O)[C@]4(C)[C@@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9300,ML00009297,,,C=C1[C@@H](OC)C/C=C\[C@@H](O[C@@H]2O[C@H](OC)[C@@H](O)[C@H](OC)[C@H]2O)CC(=O)O[C@@H](/C=C(/C)C/C=C\C)C/C=C\C=C/C[C@H](C)[C@@H]1OO,standard_macrolactone,18.0,,,success,,6.0,"[3, 10, 11, 12, 13, 17]",ring_size_18/standard/numbered/ML00009297_numbered.png,2026-03-19 06:58:55.822124
9301,ML00000787,CHEMBL251459,BEAUVERICIN G1,CC[C@H]1OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9302,ML00002547,,,CC[C@@H]1[C@H](O)[C@@H](C)/C=C(C)\C=C(\OC)C(=O)O[C@H]([C@H](C)[C@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC(=O)/C=C/C(=O)O)[C@H](C)[C@@H](C)O2)[C@@H](OC)/C=C\C=C(\C)C[C@@H](C)[C@H]1O,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00002547_numbered.png,2026-03-19 06:58:55.896508
9303,ML00006029,,,C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@@H](CC)[C@@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H]2OC)C[C@@H](O[C@H]2C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00006029_numbered.png,2026-03-19 06:58:55.962922
9304,ML00010052,,,CC(O)C1/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5O[C@]5(C)[C@H](O)C[C@]4(COC(=O)C(O)C(C)CCO1)[C@]2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9305,ML00010008,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\[C@H]([C@@H](C)O)OC[C@H](O)[C@@H](C)CC(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9306,ML00010021,,,CC1=C[C@H]2O[C@@H]3C[C@@H]4OC(=O)/C=C/C=C/COCC/C([C@@H](O)[C@H](C)O)=C/C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9307,ML00010035,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\C(C(C)O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9308,ML00010714,,,CC[C@@H]1OC(=O)[C@@H](C(C)C)NC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H]2CCCNN2C(=O)[C@H]2CCCNN2C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9309,ML00010401,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OC[C@H](O)[C@@]5(C)O[C@@H]5C(=O)OC[C@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9310,ML00010354,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OC[C@H](O)/C(C)=C\C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9311,ML00000050,CHEMBL70590,BORRELIDIN,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)O)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00000050_numbered.png,2026-03-19 06:58:56.076696
9312,ML00010989,,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](CC#CC(=O)O[C@H]([C@H](/C=C/[C@@H]3CC(C)=CCO3)OC)C[C@@H]3O[C@H]3[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9313,ML00000342,CHEMBL2206963,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(-c4ccccc4)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9314,ML00010454,,,CC1=C[C@@H]2O[C@H]3[C@@H](O)[C@H]4OC(=O)/C=C\C=C/[C@H]5O[C@@H](C/C(C)=C\C(=O)OC[C@]2(CC1)[C@@]4(C)[C@@]31CO1)O[C@@H]5C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9315,ML00002048,CHEMBL1733059,,CC1=CC2OC3CC4OC(=O)C=CC=CC(=O)OCCC(C)C(O)C(=O)OCC2(CC1)C4(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9316,ML00010036,,,CC1=C[C@@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@@H]([C@H](C)O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9317,ML00002513,,,CC(C)=CCOc1ccc(C[C@@H]2NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CO)NC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3ccccc3)OC(=O)[C@H](C)N(C)C2=O)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9318,ML00000124,CHEMBL584166,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCc1ccc3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9319,ML00009400,,,COC[C@@H]1NC(=O)[C@@H]2C[C@H](Cl)CNN2C(=O)[C@H](C(C)(C)C)OC(=O)[C@@H](C2(C)CC2)NC(=O)[C@@H]2C[C@@]3(O)c4ccc(Cl)c(Cl)c4N[C@H]3N2C(=O)[C@@H]([C@@H](O)CC(=O)O)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9320,ML00000347,CHEMBL2206976,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(OC4CCCC4)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9321,ML00010884,,,CC(=O)NC/C1=C/C=C/C[C@@H]([C@@H]2CCC[C@H]2C(=O)O)OC(=O)C[C@H](O)[C@@H](C)C[C@@H](C)C[C@@H](C)C[C@H](C)[C@H]1O,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010884_numbered.png,2026-03-19 06:58:56.201771
9322,ML00009405,,,CC(C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9323,ML00010708,,,CCCCC/C=C/C(C)=C/[C@@H]1C[C@H](C)C/C=C\CC[C@H](O)[C@@H](OC(N)=O)CC[C@H](C)C[C@@H](OC(N)=O)[C@H](C)C(=O)O1,standard_macrolactone,18.0,,,success,,7.0,"[3, 5, 11, 12, 15, 17, 18]",ring_size_18/standard/numbered/ML00010708_numbered.png,2026-03-19 06:58:56.262873
9324,ML00009207,,,CCCC[C@H]1OC(=O)[C@H](C(C)CC)N(C)C(=O)[C@@H](C)OC(=O)[C@H](C(C)CC)N(C)C(=O)[C@@H](C)OC(=O)[C@H](C(C)CC)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9325,ML00005606,,,C/C=C/[C@H]1O[C@@](O)([C@@H](C)C(O)C(C)[C@H]2OC(=O)C(OC)=CC(C)=C[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C(C)CC(C)=CC=C[C@@H]2OC)C[C@@H](O[C@H]2C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00005606_numbered.png,2026-03-19 06:58:56.335686
9326,ML00010305,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccc(O)c(I)c2)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9327,ML00003966,,,CCO[C@]12OC(=O)C(C)=C1C1=C3[C@@](C)(C2=O)[C@H]2C[C@H]2[C@@]3(O)C[C@H]2[C@@]3(C)[C@H]4C[C@H]4[C@@]4(O)COC(=O)/C(C)=C\COC(=O)CCC(=O)OCC5=C(C[C@H]34)[C@@]12OC5=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9328,ML00000239,CHEMBL1334658,,CO[C@@H]1COC(=O)C/C=C\[C@H](C)COC(=O)[C@H](Cc2ccccc2)NC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9329,ML00010103,,,C=C(C)C/C=C/C(=C)C[C@@H](C)[C@@H]1OC(=O)[C@@H](C)/C=C\C=C/[C@H](O)[C@@H](O)/C=C\CC[C@H]2CC[C@@H](O2)[C@@H]1O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9330,ML00008895,,,C/C1=C/C[C@@H](O)[C@@H](C)[C@H](O)C[C@H](O)/C(C)=C\[C@@H](C)CCC[C@H](C)[C@@H]([C@H](C)CCCC[C@H](O)CCCCC(=O)O)OC1=O,standard_macrolactone,18.0,,,success,,9.0,"[3, 4, 8, 10, 11, 13, 14, 15, 18]",ring_size_18/standard/numbered/ML00008895_numbered.png,2026-03-19 06:58:56.427915
9331,ML00007243,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\C(=O)OCC/C(C)=C/C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9332,ML00004087,,,CC(C)=CCOc1ccc(C[C@H]2NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc3ccc(O)cc3)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)OC2=O)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9333,ML00000314,CHEMBL1672610,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCC(C)(C)CCCc1ccc3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9334,ML00010854,,,CCSC(=O)[C@@H]1CCC[C@H]1[C@@H]1C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010854_numbered.png,2026-03-19 06:58:56.511979
9335,ML00007325,,,C/C1=C\[C@H](C)C[C@H](C)OC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccc(O)c(Br)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9336,ML00009161,,,CC(C)C[C@H]1C(=O)O[C@@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(C)C)C(=O)O[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9337,ML00010856,,,C/C1=C/C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)C[C@@H](C)CCC1,standard_macrolactone,18.0,,,success,,10.0,"[3, 6, 10, 12, 13, 14, 15, 16, 16, 17]",ring_size_18/standard/numbered/ML00010856_numbered.png,2026-03-19 06:58:56.585994
9338,ML00010361,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OCC[C@@]5(C)O[C@@H]5C(=O)OC[C@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9339,ML00010023,,,CC1=C[C@H]2O[C@@H]3[C@H](O)[C@H]4OC(=O)/C=C\C=C/[C@@H]([C@@H](C)O)OCC/C(C)=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9340,ML00003213,,,CC[C@H](C)[C@H]1C(=O)N[C@@H](Cc2ccc(OCC=C(C)C)cc2)C(=O)N(C)[C@@H](CC)C(=O)O[C@H](Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CO)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9341,ML00010364,,,C[C@@H](O)[C@H]1/C=C\C=C/C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5O[C@]5(C)CC[C@@]4(COC(=O)[C@H]4O[C@]4(C)CCO1)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9342,ML00011024,,,CC(C)/C=C/C=C/C[C@@H]1NC(=O)[C@H]2C[C@@H](O)CNN2C(=O)COC(=O)[C@](C)(CO)NC(=O)[C@H]2CCCNN2C(=O)[C@H]2C[C@H](Cl)CNN2C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9343,ML00009293,,,C/C=C/C/C(C)=C\[C@H]1C/C=C\C=C/C[C@H](C)/C=C(/C)[C@@H](OC)C/C=C\[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](OC)[C@H]2O)CC(=O)O1,standard_macrolactone,18.0,,,success,,5.0,"[3, 10, 12, 13, 17]",ring_size_18/standard/numbered/ML00009293_numbered.png,2026-03-19 06:58:56.665772
9344,ML00010879,,,CC(=O)NC/C1=C/C=C/C[C@@H]([C@@H]2CCC[C@H]2C(N)=O)OC(=O)C[C@H](O)[C@@H](C)C[C@@H](C)C[C@@H](C)C[C@H](C)[C@H]1O,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010879_numbered.png,2026-03-19 06:58:56.718129
9345,ML00010346,,,C/C1=C/C(=O)OC[C@@]23CC[C@@]4(C)O[C@H]4[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OC[C@@H]1O)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9346,ML00010875,,,CCC(C)[C@H]1C(=O)O[C@H](C)C(=O)N(C)[C@@H](C(C)CC)C(=O)O[C@H](C)C(=O)N(C)[C@@H](C(C)CC)C(=O)O[C@H](C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9347,ML00002226,,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C(C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C(C)=C\COC(=O)[C@@H](OC(C)=O)CC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@H]31)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9348,ML00010309,,,C/C(=C\c1csc(C)n1)[C@@H]1C/C=C\CCC[C@@H](C)C[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,18.0,,,success,,8.0,"[3, 10, 12, 13, 14, 15, 16, 17]",ring_size_18/standard/numbered/ML00010309_numbered.png,2026-03-19 06:58:56.798281
9349,ML00001942,CHEMBL154629,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@@H]3CC(C)=CCO3)C[C@@H]3O[C@H]3[C@@H](OC(C)=O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9350,ML00010462,,,CC(=O)OC1C(=O)OC[C@]23CC[C@@]4(C)O[C@H]4[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C\C(=O)OCCC1C)[C@@]3(C)C21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9351,ML00009999,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\[C@H]([C@@H](C)O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9352,ML00010047,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OC[C@@H](O)[C@H](C)CC(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9353,ML00001040,CHEMBL4081164,,C[C@@H]1NC(=O)OC(c2cccc(Cl)c2)CCCCCCNC(=O)CC[C@@H](C=O)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9354,ML00003967,,,CCO[C@]12OC(=O)C(C)=C1C1=C3[C@](O)(C[C@H]4[C@@]5(C)[C@@H]6C[C@@H]6[C@@]6(O)COC(=O)/C(C)=C/COC(=O)CCC(=O)OCC7=C(C[C@@H]65)[C@@]14OC7=O)[C@H]1C[C@H]1[C@]3(C)C2=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9355,ML00009980,,,C=C1C[C@@H]2C/C=C\[C@H](O)[C@H](C)/C(C)=C\C(=O)O[C@H](C[C@H](C)[C@H](C)O)[C@@H](C)C/C=C\[C@@](C)(O)[C@](O)(C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9356,ML00000871,CHEMBL251462,BEAUVERICIN H2,CC(C)[C@H]1OC(=O)[C@H](Cc2cccc(F)c2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2cccc(F)c2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9357,ML00008309,,,CO[C@@H]1COC(=O)[C@H](C)NC(=O)[C@@H](C)COC(=O)[C@H](C)NC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9358,ML00008126,,,O=C1CCCCCCCCC(=O)OCCCCCCO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9359,ML00001164,CHEMBL422513,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C/C(=O)O[C@H]([C@@H](O)/C=C/[C@@H]3CC(C)=CCO3)C/C=C/[C@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9360,ML00000460,CHEMBL2206984,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(nc4ccccc4c3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9361,ML00001907,CHEMBL349998,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@@H]3CC(C)=CCO3)C[C@@H]3O[C@H]3[C@H](OC(=O)N(C)C)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9362,ML00007600,,,C[C@@]12[C@H]3C[C@@H](O[C@@H]4[C@@H]5O[C@]5(C)CC[C@@]41COC(=O)[C@H]1O[C@]1(C)CCOC(=O)/C=C/C=C\C(=O)O3)[C@@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9363,ML00010702,,,CC(C)[C@@H]1NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](C(C)C)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9364,ML00003379,,,CC1=C2C3=C4[C@](O)(C[C@@]5(C)[C@@]6(C)[C@@H]7C[C@@H]7[C@@]7(O)COC(=O)/C=C/COC(=O)CCC(=O)OCC8=C(C[C@@H]76)[C@@]35OC8=O)[C@H]3C[C@H]3[C@]4(C)[C@@H](O)[C@@]2(O)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9365,ML00010356,,,C/C1=C/C(=O)OC[C@@]23CCC(CO)=C[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OC[C@@H]1O)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9366,ML00010054,,,CC(O)C1C=CC=CC(=O)OC2CC3OC4C5OC5(C)C(O)CC4(COC(=O)C(O)C(C)CCO1)C2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9367,ML00000058,CHEMBL373872,BEAUVERICIN,CC(C)[C@@H]1OC(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9368,ML00010283,,,C/C1=C/C=C/C[C@@H]([C@@H]2CCC[C@H]2C(=O)O)OC(=O)C[C@H](O)[C@@H](C)C[C@@H](C)C[C@@H](C)C[C@H](C)[C@H]1O,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010283_numbered.png,2026-03-19 06:58:56.983496
9369,ML00000313,CHEMBL1672607,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCCCCCc1cc(OC)c3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9370,ML00008961,,,CCC(C)C1C(=O)OC(C(C)C)C(=O)N(C)C(C(C)C)C(=O)OC(C(C)C)C(=O)N(C)C(C(C)C)C(=O)OC(CC(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9371,ML00004150,,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C(C[C@@H]4[C@]5(OC(=O)C6=C5C[C@@H]5[C@](O)(COC(=O)/C=C(/C)COC(=O)[C@@H](O)CC(=O)OC6)[C@H]6C[C@H]6[C@@]54C)[C@H]31)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9372,ML00006121,,,C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@@H](O)[C@@H](C)[C@H]2OC(=O)/C(OC)=C\C(C)=C/[C@H](C)[C@@H](O)[C@@H](CC)[C@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H]2OC)C[C@@H](OC(=O)/C=C/C(=O)NC2=C(O)CCC2=O)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00006121_numbered.png,2026-03-19 06:58:57.065397
9373,ML00010037,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@@H]([C@H](C)O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9374,ML00010006,,,CC(O)C1/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5O[C@]5(C)CC[C@]4(COC(=O)C(O)C(C)CCO1)[C@]2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9375,ML00010014,,,C[C@H](O)[C@H]1/C=C\C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5O[C@]5(C)CC[C@]4(COC(=O)C[C@@H](C)[C@@H](O)CO1)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9376,ML00004194,,,CO[C@]12OC(=O)C(C)=C1C1=C3C(=C[C@H]4[C@@]5(C)[C@@H]6C[C@@H]6[C@@]6(O)COC(=O)/C(C)=C/COC(=O)CCC(=O)OCC7=C(C[C@@H]65)[C@@]14OC7=O)[C@H]1C[C@H]1[C@]3(C)[C@H]2O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9377,ML00006000,,,CC(C)C1OC(=O)C(Cc2ccccc2)N(C)C(=O)C(C(C)C)OC(=O)C(Cc2ccccc2)N(C)C(=O)C(C(C)C)OC(=O)C(Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9378,ML00007679,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H](C[C@@H](C)C(=O)O)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00007679_numbered.png,2026-03-19 06:58:57.148307
9379,ML00001887,CHEMBL1367868,,CO[C@@H]1COC(=O)C/C=C\[C@H](C)COC(=O)[C@H](C)NC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9380,ML00010351,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OC[C@H](O)/C(C)=C\C(=O)OC[C@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9381,ML00010406,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\[C@H]([C@@H](C)O)OC[C@H](O)[C@@]5(C)O[C@@H]5C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9382,ML00009910,,,CCC(C)[C@@H]1OC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)c2cccc(N)c2O)[C@@H](C)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)C(=O)[C@H](CC(C)C)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9383,ML00009230,,,CCC(=O)[C@@H](C)[C@@H](O)[C@H](C)C[C@@H](C)[C@H]1OC(=O)C[C@@]2(O)CC=C(C)[C@H](O2)/C(C)=C\CCC[C@@H](O)/C=C\[C@H](C)C[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9384,ML00001698,CHEMBL386978,,CN1C2CCC1C1COC(=O)CCCCCCCC(=O)Nc3ccc(cc3)C1C2,non_standard_macrocycle,18.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
9385,ML00001671,CHEMBL2426320,,CO[C@@H]1C(=O)O[C@H](C)[C@H](C)/C=C(\C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Cl)[nH]c3ccccc23)C(=O)N[C@H]1c1ccc(O)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9386,ML00010408,,,C[C@@H](O)[C@H]1/C=C\C=C/C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5O[C@]5(C)CC[C@]4(COC(=O)[C@H]4O[C@]4(C)[C@H](O)CO1)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9387,ML00010533,,,CC[C@@H](C)/C=C/C=C/C[C@@H]1NC(=O)[C@H]2C[C@@H](O)CNN2C(=O)COC(=O)[C@](C)(CO)NC(=O)[C@@H]2C[C@H](O)CNN2C(=O)[C@H]2C[C@H](Cl)CNN2C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9388,ML00010032,,,CC1=C[C@H]2O[C@@H]3C[C@@H]4OC(=O)CC/C=C\[C@H]([C@@H](C)O)OCC/C(C)=C\C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9389,ML00007224,,,CC1=C[C@H]2O[C@H]3C[C@H]4OC(=O)/C=C\C=C/C(=O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(CC1)[C@@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9390,ML00009035,,,C/C=C(C)/C=C(\C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H]1OC(=O)/C(CCCCCC)=C\c2csc(n2)[C@H](C)[C@@H](O)C[C@H](O)/C=C\C=C/C[C@@H]1O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9391,ML00006797,,,N[C@H]1CCCCNc2nc(ncc2C(=O)NCc2ccc(F)cc2)NCCCCCCOC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9392,ML00002681,,,CCC(=O)[C@H](C)[C@H](O)[C@H](C)C[C@H](C)[C@@H]1OC(=O)C[C@]2(O)CC=C(C)[C@H](O2)/C(C)=C\CCC[C@H](O[C@H]2C[C@@H](OC(N)=O)[C@H](O)[C@@H](C)O2)/C=C\[C@@H](C)C[C@@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9393,ML00001178,CHEMBL365169,,C=C1CCC[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@@H]3CC(C)=CCO3)C/C=C/[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9394,ML00010362,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OCC[C@]5(C)O[C@@H]5C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9395,ML00001645,CHEMBL1744502,,CC=C[C@H]1O[C@@](O)([C@@H](C)C(O)C(C)[C@H]2OC(=O)C(OC)=CC(C)=C[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C(C)CC(C)=CC=C[C@@H]2OC)C[C@@H](O[C@H]2C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00001645_numbered.png,2026-03-19 06:58:57.342586
9396,ML00010754,,,CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)OC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9397,ML00003329,,,CC1=C2C3=C4[C@](O)(C[C@H]5[C@@]6(C)[C@@H]7C[C@@H]7[C@@]7(O)COC(=O)/C=C(/C)COC(=O)CCC(=O)OCC8=C(C[C@@H]76)[C@@]35OC8=O)[C@H]3C[C@H]3[C@]4(C)C(=O)[C@@]2(O)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9398,ML00005596,,,C/C=C/[C@H]1O[C@](O)([C@H](C)[C@H](O)[C@H](C)[C@@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@H](CC)[C@H](O)[C@H](C)C/C(C)=C\C=C/[C@H]2OC)C[C@H](O[C@@H]2C[C@@H](O)[C@H](O)[C@@H](C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00005596_numbered.png,2026-03-19 06:58:57.426515
9399,ML00005813,,,C/C=C/[C@H]1O[C@](O)([C@H](C)[C@H](O)[C@H](C)[C@@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@H](C)[C@H](O)[C@H](C)C/C(C)=C\C=C/[C@H]2OC)C[C@H](O[C@@H]2C[C@@H](O)[C@H](O)[C@@H](C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00005813_numbered.png,2026-03-19 06:58:57.493462
9400,ML00007597,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/C(=O)OC[C@H](O)/C(C)=C\C(=O)OC[C@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9401,ML00001177,CHEMBL193919,,C=C1CCC[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@@H]3CC(C)=CCO3)C[C@@H]3O[C@H]3[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9402,ML00002678,,,CCC(=O)[C@@H](C)[C@@H](O)[C@H](C)C[C@@H](C)C1OC(=O)C[C@@]2(O)CC=C(C)C(O2)C(C)=CCCC[C@H](O[C@H]2C[C@@H](OC(N)=O)[C@H](O)[C@@H](C)O2)C=C[C@H](C)C[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9403,ML00003374,,,COC(=O)/C(C)=C1/C(=O)[C@H](O)[C@H]2[C@@H]3C[C@@H]3C3=C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C(C)=C\COC(=O)[C@@H](O)CC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@@H]1[C@]32OO,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9404,ML00008900,,,CC(C)C[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9405,ML00004124,,,CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@](C)(C(=O)[C@H](O)C1=C(C)C3C[C@@](O)(C(C)OC(=O)CC/C=C/CCC(=O)N[C@@H](c4ccccc4)[C@@H](O)C(=O)O3)C1(C)C)C2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9406,ML00007681,,,CC(C)(C)c1cc(C2COC(=O)COCCOCC(=O)OCCOCCO2)cc(C(C)(C)C)c1O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9407,ML00010404,,,CC1=CC2OC3CC4OC(=O)/C=C\C=C/C(C(C)O)OCC(O)C5(C)OC5C(=O)OCC2(CC1O)C4(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9408,ML00001323,CHEMBL2426324,,COc1ccc([C@@H]2NC(=O)[C@@H](Cc3c[nH]c4ccccc34)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C/C(C)=C/[C@@H](C)[C@@H](C)OC(=O)[C@H]2OC)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9409,ML00007599,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\C(=O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(CC1=O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9410,ML00010110,,,CC(C)C[C@@H]1OC(=O)[C@@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)CNC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9411,ML00010059,,,C[C@H](O)[C@H]1/C=C\C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4C=C(CO)CC[C@@]4(COC(=O)C[C@@H](C)[C@H](O)CO1)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9412,ML00010456,,,C/C1=C\C(=O)OC[C@]23CC[C@@]4(C)O[C@H]4[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C\C4OC(C1)OC4C)[C@@]3(C)C21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9413,ML00003935,,,CCC(=O)[C@@H](C)[C@@H](O)[C@H](C)C[C@@H](C)[C@@H]1OC(=O)C[C@@]2(O)CC=C(C)[C@@H](O2)/C(C)=C\CCC[C@@H](O[C@H]2C[C@@H](O)[C@H](O)[C@@H](C)O2)/C=C\[C@@H](C)C[C@@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9414,ML00010458,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]5O[C@H](C/C(C)=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@@]31CO1)O[C@@H]5C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9415,ML00011016,,,C=CCOC(=O)[C@@H]1CCC[C@H]1[C@@H]1C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00011016_numbered.png,2026-03-19 06:58:57.674031
9416,ML00010463,,,CC(=O)O[C@@H]1C(=O)OC[C@]23CC[C@@]4(C)O[C@H]4[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C\C(=O)OCC[C@H]1C)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9417,ML00010753,,,CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C(C)C)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9418,ML00010053,,,CC(O)C1/C=C/C=C\C(=O)OC2CC3OC4C5OC5(C)C(O)CC4(COC(=O)C(O)C(C)CCO1)C2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9419,ML00007366,,,CCC(C)[C@H]1C(=O)O[C@H](C)C(=O)N(C)[C@@H](C(C)CC)C(=O)O[C@H](C)C(=O)N(C)[C@@H](C)C(=O)O[C@H](C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9420,ML00010897,,,CC(=O)O[C@H]1C[C@@]23COC(=O)/C=C(/C)C[C@@H]4O[C@H](C)[C@@H](/C=C\C=C/C(=O)O[C@@H]5C[C@@H](O[C@@H]2C=C1C)[C@@]1(CO1)[C@]53C)O4,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9421,ML00009378,,,CC[C@H](C)[C@@H]1OC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)C(=O)[C@H](CC(C)C)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9422,ML00004484,,,CC1NC(=O)C(NC(=O)c2cnc3ccccc3n2)COC(=O)C(C(C)C(C)C)N(C)C(=O)C2CSSCC(C(=O)N(C)C(C(C)C(C)C)C(=O)OCC(NC(=O)c3cnc4ccccc4n3)C(=O)NC(C)C(=O)N2C)N(C)C1=O,non_standard_macrocycle,18.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
9423,ML00010336,,,C[C@@H]1C[C@H](C)[C@@H](O)/C(C#N)=C\C=C/C[C@@H]([C@@H]2CCC[C@@H]2C(=O)O)OC(=O)C[C@@H](O)[C@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010336_numbered.png,2026-03-19 06:58:57.784991
9424,ML00008903,,,CC(C)C[C@@H]1OC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C(C)C)OC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9425,ML00009278,,,CC[C@H](C)[C@H]1NC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H]2CCCNN2C(=O)[C@H]2C[C@@H](Cl)CNN2C(=O)[C@H](C(C)C)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9426,ML00001073,CHEMBL1169410,,C=C1CCC[C@@H]2CCC[C@@H](C/C=C\C(=O)O[C@H](CO)C[C@@H]3O[C@H]3[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9427,ML00004099,,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C1[C@]14OC(=O)C5=C1C[C@H]1[C@](O)(COC(=O)/C(C)=C\COC(=O)CCC(=O)OC5)[C@H]5C[C@H]5[C@]1(C)[C@@H]4C[C@]3(OO)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9428,ML00010387,,,C[C@H](O)[C@H]1/C=C\C=C/C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5O[C@]5(C)CC[C@]4(COC(=O)[C@H]4O[C@]4(C)[C@H](O)CO1)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9429,ML00010034,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\[C@H]([C@@H](C)O)OCC[C@@H](C)[C@@H](O)C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9430,ML00007317,,,C/C=C/C/C(C)=C\[C@H]1C/C=C\C=C/C[C@H](C)/C=C(/C)[C@@H](OC)C[C@@H](O)C[C@@H](O)CC(=O)O1,standard_macrolactone,18.0,,,success,,6.0,"[3, 10, 12, 13, 15, 17]",ring_size_18/standard/numbered/ML00007317_numbered.png,2026-03-19 06:58:57.867507
9431,ML00004100,,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C1[C@]14OC(=O)C5=C1C[C@H]1[C@](O)(COC(=O)/C=C(/C)COC(=O)CCC(=O)OC5)[C@H]5C[C@H]5[C@]1(C)[C@@H]4C[C@]3(OO)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9432,ML00010258,,,Cc1c2cc3c(c1O)C(=O)C[C@@H](O3)c1ccc(O)c(c1)-c1ccc(O)c(c1)C(=O)OC[C@@H]1O[C@@H](O2)[C@@H](O)[C@@H](O)[C@@H]1O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9433,ML00006486,,,CC[C@H](C)[C@H]1OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]([C@@H](C)CC)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]([C@@H](C)CC)OC(=O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9434,ML00007646,,,O=C1CC[C@@H](C(O)S(=O)(=O)O)NC(=O)C2(CCCCC2)NC(=O)OC(c2cccc(Cl)c2)CCCCCCN1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9435,ML00010412,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@@H]5O[C@H](C/C(C)=C\C(=O)OC[C@@]2(C[C@@H]1O)[C@]4(C)[C@]31CO1)O[C@H]5C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9436,ML00007234,,,C[C@@H]1CCOC(=O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5OC5(C)CC[C@]4(COC(=O)[C@H]1O)[C@]2(C)[C@@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9437,ML00004190,,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C(C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C(C)=C\CCC(=O)OCC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@H]31)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9438,ML00010058,,,C[C@@H]1CC(=O)OC[C@@]23CCC(CO)=C[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OC[C@H]1O)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9439,ML00010084,,,C[C@@H](O)C1/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@H]5O[C@@]5(C)CC[C@]4(COC(=O)[C@H]4C[C@]4(C)CCO1)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9440,ML00005605,,,C/C=C\[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)[C@H](C)C/C(C)=C\C=C/[C@H]2OC)C[C@@H](O[C@H]2C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00005605_numbered.png,2026-03-19 06:58:57.990204
9441,ML00007327,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccc(O)c(Br)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9442,ML00007344,,,C[C@@H]1CCOC(=O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5C[C@]5(CO)CC[C@]4(COC(=O)[C@H]1O)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9443,ML00003965,,,COC(=O)/C(C)=C1/C(=O)[C@H](O)[C@@H]2C3=C1[C@]14OC(=O)C5=C1C[C@H]1[C@](O)(COC(=O)/C(C)=C\COC(=O)[C@@H](OC(C)=O)CC(=O)OC5)[C@H]5C[C@H]5[C@]1(C)[C@@H]4C[C@]3(O)[C@H]1C[C@@H]21,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9444,ML00010719,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)OCCN(C)C)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010719_numbered.png,2026-03-19 06:58:58.071401
9445,ML00010983,,,CO[C@H]1C[C@@H](C)CCc2nc(co2)/C(C)=C\[C@H](O)[C@@H](C)/C=C\C(=O)O[C@@H](/C=C(\C)C/C=C\C[C@](C)(O)C(=O)O)[C@@H]1O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9446,ML00009165,,,CC[C@@H](C)[C@H]1C(=O)O[C@H](Cc2ccccc2N)C(=O)N(C)[C@@H]([C@H](C)CC)C(=O)O[C@H](C)C(=O)N(C)[C@@H](C)C(=O)O[C@H](C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9447,ML00007223,,,C=C1[C@H]2C[C@H]3OC(=O)/C=C\C=C/C(=O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]4(CCC(C)=C[C@H]4O2)[C@]13C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9448,ML00009295,,,C/C=C\[C@H](C)[C@H]1O[C@@]1(C)[C@@H](O)[C@H]1COC(=O)[C@H](O)[C@@H](OC)[C@H](C)C(=O)[C@H](C)[C@@H](OC(C)=O)/C(C)=C/[C@H](C)C(=O)C[C@H](O)[C@@](O)(CO)C1=O,standard_macrolactone,18.0,,,success,,14.0,"[4, 5, 6, 6, 7, 9, 10, 12, 13, 14, 15, 16, 17, 18]",ring_size_18/standard/numbered/ML00009295_numbered.png,2026-03-19 06:58:58.175641
9449,ML00010113,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)NCC(=O)O)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010113_numbered.png,2026-03-19 06:58:58.233335
9450,ML00010995,,,CC(=O)O[C@H](C)[C@H]1/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4C=C(C)CC[C@]4(COC(=O)/C=C(\C)CCO1)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9451,ML00010530,,,C/C=C\[C@H](C)[C@H]1O[C@]1(C)[C@@H](O)[C@H]1COC(=O)[C@H](O)[C@@H](OC)[C@H](C)C(=O)[C@H](C)[C@@H](O)/C(C)=C\[C@H](C)C(=O)CC[C@@H](C)C1=O,standard_macrolactone,18.0,,,success,,12.0,"[4, 5, 6, 9, 10, 12, 13, 14, 15, 16, 17, 18]",ring_size_18/standard/numbered/ML00010530_numbered.png,2026-03-19 06:58:58.311708
9452,ML00010450,,,CC1=C[C@H]2O[C@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC/C(C)=C\C(=O)OC[C@@]2([C@H]2O[C@@H]12)[C@@]4(C)[C@@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9453,ML00010050,,,CC(O)C1/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5O[C@]5(CO)CC[C@]4(COC(=O)C(O)C(C)CCO1)[C@]2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9454,ML00010365,,,C/C1=C/C(=O)OC[C@]23CC[C@](C)(O)[C@H]4C[C@]5(O)[C@H](O[C@H]42)[C@H](O)[C@@H](OC(=O)/C=C\C=C/[C@@H]2O[C@H](C1)O[C@H]2C)[C@@]53C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9455,ML00010163,,,CCC(C)[C@H]1C(=O)O[C@H](C)C(=O)N(C)[C@@H](C(C)CC)C(=O)O[C@H](C)C(=O)N(C)[C@@H](C(C)CC)C(=O)OCC(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9456,ML00010357,,,CC(=O)OC1C(=O)OC[C@]23CC[C@H](C)C[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C\C(=O)OCCC1C)[C@@]3(C)C21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9457,ML00009940,,,C/C1=C/C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)[C@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CC(C)CCC1,standard_macrolactone,18.0,,,success,,9.0,"[3, 6, 10, 12, 13, 14, 15, 16, 17]",ring_size_18/standard/numbered/ML00009940_numbered.png,2026-03-19 06:58:58.406289
9458,ML00010000,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\C(C(C)O)OCCC(C)C(O)C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9459,ML00000716,CHEMBL1672603,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCc1cc(C(F)(F)F)c3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9460,ML00004109,,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C([C@H]4C[C@H]42)[C@H](O)[C@H]2[C@@]4(C)[C@@H]5C[C@@H]5[C@@]5(O)COC(=O)/C(C)=C/COC(=O)CCC(=O)OCC6=C(C[C@@H]54)[C@@]2(OC6=O)[C@H]31,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9461,ML00002093,CHEMBL351803,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@@H]3CC(C)=CCO3)C[C@H]3O[C@@H]3[C@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9462,ML00009478,,,COC[C@@H]1NC(=O)[C@@H]2CCC=NN2C(=O)[C@H](C(C)(C)C)OC(=O)[C@@H](C2(C)CC2)NC(=O)[C@@H]2C[C@@]3(O)c4ccc(Cl)c(Cl)c4N[C@H]3N2C(=O)[C@@H]([C@H](O)CC(=O)O)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9463,ML00000309,CHEMBL1811934,SHIZUKAOL H,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C(C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C=C(\C)COC(=O)[C@@H](O)CC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@H]31)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9464,ML00009858,,,CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)OC(=O)CN(C)C(=O)[C@H]([C@H](C)CC)NC(=O)[C@@H](Cc2ccccc2)OC(=O)CN(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9465,ML00002495,,,CC(C)C[C@@H]1OC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9466,ML00010261,,,Cc1c2cc3c(c1O)C(=O)C[C@@H](O3)c1ccc(O)c(c1)-c1cccc(c1O)C(=O)OC[C@@H]1O[C@@H](O2)[C@@H](O)[C@@H](O)[C@@H]1O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9467,ML00010369,,,C=C1C[C@@H]2/C=C(/C)C[C@H]([C@@H](O)NC(=O)/C=C\C=C\C)OC(=O)/C=C\C=C(\C)CC(=O)/C=C\C[C@H](C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9468,ML00010715,,,CC[C@@H]1OC(=O)[C@H](C(C)C)NC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H]2CCCNN2C(=O)[C@H]2CCCNN2C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9469,ML00010696,,,CCCCC/C=C\C(C)=C/[C@@H]1C[C@H](C)C/C=C\CC[C@@H](O)[C@H](OC(N)=O)CC[C@@H](C)C[C@H](OC(N)=O)[C@H](C)C(=O)O1,standard_macrolactone,18.0,,,success,,7.0,"[3, 5, 11, 12, 15, 17, 18]",ring_size_18/standard/numbered/ML00010696_numbered.png,2026-03-19 06:58:58.541275
9470,ML00000788,CHEMBL4097122,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C(C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C(C)=C/COC(=O)[C@@H](O)CC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@H]31)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9471,ML00009957,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](Cc2ccc(O)c(I)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9472,ML00004107,,,COC(=O)/C(C)=C1\C(=O)[C@@H](O)[C@@]2(C)C3=C([C@@H](O)[C@H]4[C@@]5(OC(=O)C6=C5C[C@H]5[C@@]4(C)[C@H]4C[C@H]4[C@]5(O)COC(=O)/C(C)=C\COC(=O)CCC(=O)OC6)[C@@H]31)[C@@H]1C[C@@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9473,ML00009997,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\[C@H]([C@H](C)O)OCC[C@@H](C)[C@@H](O)C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9474,ML00008986,,,CC(C)C[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9475,ML00009934,,,C/C(=C\c1csc(C)n1)[C@@H]1C/C=C\CCCC(C)C[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,18.0,,,success,,9.0,"[3, 10, 12, 13, 14, 15, 16, 16, 17]",ring_size_18/standard/numbered/ML00009934_numbered.png,2026-03-19 06:58:58.627885
9476,ML00010396,,,C=C1[C@H]2C[C@H]3OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OCC/C(C)=C\C(=O)OC[C@@]4(CCC(C)=C[C@H]4O2)[C@]13C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9477,ML00003378,,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C(C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C(O)=C\COC(=O)C(O)CC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@H]31)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9478,ML00007431,,,CC1=CC2OC3CC4OC(=O)/C=C/C=C/C(=O)OCCC(C)C(O)C(=O)OOC2(CC1)C4(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9479,ML00007553,,,C=C1C[C@@H](CCC)OC(=O)[C@@H](C)CCCC[C@@H]2O[C@H](C[C@@H]2C)C[C@@H](O)C(=O)[C@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9480,ML00010359,,,C/C1=C/C(=O)OC[C@]23CC[C@@]4(C)O[C@H]4[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OC[C@@H]1O)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9481,ML00003548,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)OCc2cn(-c3ccc(C(=O)O)cc3)nn2)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00003548_numbered.png,2026-03-19 06:58:58.711452
9482,ML00000049,CHEMBL136396,VERRUCARRIN M,CC1=C[C@H]2O[C@@H]3[C@H](O)[C@H]4OC(=O)/C=C\C=C\C(=O)OCC/C(C)=C/C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9483,ML00010127,,,C=C1C[C@H](O)[C@@H]2O[C@H]2C[C@@H]([C@@H](O)/C=C/[C@H]2CC(C)=CCO2)OC(=O)/C=C\C[C@@H]2C=CC[C@@H](C[C@H](C)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9484,ML00010410,,,C[C@@H](O)[C@H]1/C=C\C=C/C(=O)O[C@@H]2C[C@H]3O[C@H]4[C@@H]5O[C@]5(C)CC[C@]4(COC(=O)[C@H]4O[C@]4(C)[C@@H](O)CO1)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9485,ML00010039,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OC[C@H](O)[C@@H](C)CC(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9486,ML00009890,,,CC[C@H](C)[C@@H]1OC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC(=O)[C@H](C(C)C)OC(=O)C(C)(C)C(=O)[C@H](CC(C)C)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9487,ML00010355,,,C/C1=C/C(=O)OC[C@]23CCC(CO)=C[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OC[C@@H]1O)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9488,ML00000832,CHEMBL1672604,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCc1cc(S(C)(=O)=O)c3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9489,ML00009996,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9490,ML00007606,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/C(=O)OCC/C(C)=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9491,ML00009292,,,C/C=C/C/C(C)=C/[C@H]1C/C=C\C=C/C[C@H](C)/C=C(/C)[C@@H](OC)C/C=C\[C@@H](O[C@@H]2O[C@H](OC)[C@@H](O)[C@H](OC)[C@H]2O)CC(=O)O1,standard_macrolactone,18.0,,,success,,5.0,"[3, 10, 12, 13, 17]",ring_size_18/standard/numbered/ML00009292_numbered.png,2026-03-19 06:58:58.815383
9492,ML00000346,CHEMBL2206971,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(N4CCCCC4)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9493,ML00000302,CHEMBL2206975,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(OCC)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9494,ML00003349,,,CC1=C2C3=C4[C@](O)(C[C@H]5[C@@]6(C)[C@H]7C[C@@H]7[C@@]7(O)COC(=O)/C=C(\C)COC(=O)CCC(=O)OCC8=C(C[C@@H]76)[C@@]35OC8=O)[C@H]3C[C@H]3[C@]4(C)[C@@H](O)[C@@]2(O)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9495,ML00001352,CHEMBL1672593,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](c1ccccc1)NC(=O)OCCCCCc1ccc3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9496,ML00000264,CHEMBL1554070,,Cc1ccc(S(=O)(=O)N[C@@H]2COC(=O)C/C=C\[C@H](C)COC(=O)N[C@@H](C)C(=O)C/C=C\[C@H]2C)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9497,ML00010399,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OC[C@@H](O)[C@@]5(C)O[C@@H]5C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9498,ML00004088,,,CC(C)=CCOc1ccc(C[C@H]2NC(=O)[C@@H](C)NC(=O)[C@@H](Cc3ccc(O)cc3)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@H](Cc3ccccc3)OC2=O)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9499,ML00009239,,,C=C1[C@@H](OC)C/C=C\[C@@H](O[C@@H]2O[C@H](OC)[C@@H](O)[C@H](OC)[C@H]2O)CC(=O)O[C@@H](/C=C(\C)C/C=C/C)C/C=C\C=C/C[C@H](C)[C@@H]1OO,standard_macrolactone,18.0,,,success,,6.0,"[3, 10, 11, 12, 13, 17]",ring_size_18/standard/numbered/ML00009239_numbered.png,2026-03-19 06:58:58.909160
9500,ML00007329,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccc(O)c(Br)c2)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9501,ML00005704,,,CC[C@H](C)[C@H]1OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9502,ML00007899,,,C[C@@H]1OC(=O)CCCCCCC[C@H]2O[C@H]2[C@H](O)C#CC#C[C@H]1O,standard_macrolactone,18.0,,,success,,3.0,"[3, 4, 9]",ring_size_18/standard/numbered/ML00007899_numbered.png,2026-03-19 06:58:58.955005
9503,ML00010345,,,C/C1=C/C(=O)OC[C@]23CC[C@@]4(C)O[C@H]4[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OC[C@@H]1O)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9504,ML00007421,,,C/C1=C\C(=O)OC[C@]23CC[C@@]4(C)O[C@H]4[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C\C(=O)OCC1)[C@@]3(C)C21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9505,ML00010019,,,C/C1=C/C(=O)OC[C@]23CCC(CO)=C[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OCC1)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9506,ML00009283,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)OCCN2CCOCC2)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00009283_numbered.png,2026-03-19 06:58:59.023374
9507,ML00001384,CHEMBL2036048,,CC1=C2C3=C4C(=C[C@H]5[C@@]6(C)[C@@H]7C[C@@H]7[C@@]7(O)COC(=O)/C(C)=C/COC(=O)CCC(=O)OCC8=C(C[C@@H]76)[C@@]35OC8=O)[C@H]3C[C@H]3[C@]4(C)[C@@H](O)[C@@]2(O)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9508,ML00000591,CHEMBL1414673,,CO[C@@H]1COC(=O)C/C=C\[C@@H](C)COC(=O)[C@H](COCc2ccccc2)NC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9509,ML00009164,,,CC[C@@H](C)[C@H]1C(=O)O[C@H](Cc2cccc(N)c2)C(=O)N(C)[C@@H]([C@H](C)CC)C(=O)O[C@H](C)C(=O)N(C)[C@@H](C)C(=O)O[C@H](C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9510,ML00010203,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OCC[C@@]5(C)O[C@@H]5C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9511,ML00001292,CHEMBL2426330,,CO[C@@H]1C(=O)O[C@H](C)[C@H](C)/C=C(\C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1ccc(-c2ccccc2)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9512,ML00010919,,,CCCSC(=O)[C@@H]1CCC[C@H]1[C@@H]1C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010919_numbered.png,2026-03-19 06:58:59.104397
9513,ML00009438,,,COC[C@@H]1NC(=O)[C@@H]2C[C@@H](Cl)CNN2C(=O)[C@H](C(C)(C)C)OC(=O)[C@@H](C2(C)CC2)NC(=O)[C@@H]2C[C@@]3(O)c4ccc(Cl)c(Cl)c4N[C@H]3N2C(=O)[C@@H]([C@@H](O)CC(=O)O)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9514,ML00000612,CHEMBL1699691,,CC(=O)OC1C(=O)OCC23CCC4(C)OC4C2OC2CC(OC(=O)C=CC=CC(=O)OCCC1C)C3(C)C21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9515,ML00000105,CHEMBL1813268,SHIZUKAOL F,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C(C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C=C(\C)COC(=O)CCC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@H]31)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9516,ML00001963,CHEMBL2426321,,C/C1=C\[C@@H](C)[C@@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9517,ML00000323,CHEMBL2206965,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(-c4cccc(OC)c4)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9518,ML00009263,,,C/C=C/C/C(C)=C\[C@H]1C[C@H]2C=C[C@H](C[C@H](C)/C=C(/C)[C@@H](OC)C/C=C\[C@@H](O[C@@H]3O[C@H](OC)[C@@H](O)[C@H](OC)[C@H]3O)CC(=O)O1)OO2,non_standard_macrocycle,18.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
9519,ML00007330,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](CO)NC(=O)[C@@H](Cc2ccc(O)c(Br)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9520,ML00002682,,,CCC(=O)[C@@H](C)[C@@H](O)[C@H](C)C[C@@H](C)[C@H]1OC(=O)C[C@@]2(O)CC=C(C)[C@H](O2)/C(C)=C\CCC[C@@H](O[C@H]2C[C@@H](OC(N)=O)[C@H](O)[C@@H](C)O2)/C=C\[C@H](C)C[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9521,ML00003525,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)OCc2cn(CSc3ccccc3)nn2)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00003525_numbered.png,2026-03-19 06:58:59.214872
9522,ML00000459,CHEMBL2206981,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(OCc4ncco4)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9523,ML00007213,,,C[C@@H]1CCOC(=O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5O[C@]5(C)[C@H](O)C[C@]4(COC(=O)[C@H]1O)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9524,ML00010405,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\C(C(C)O)OCC(O)C5(C)OC5C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9525,ML00005998,,,CC(C)[C@H]1OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9526,ML00010383,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\[C@H]([C@@H](C)O)OCC/C(C)=C/C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9527,ML00004148,,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C(C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C(C)=C\COC(=O)[C@@H](O)CC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@H]31)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9528,ML00009003,,,CC[C@H](C)[C@H]1NC(=O)[C@@H](C(C)C)OC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@@H](CC(C)C)OC(=O)[C@@H](CC(C)C)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9529,ML00008964,,,CC[C@H](C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H]([C@H](C)CC)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9530,ML00011030,,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](CCCC(=O)O[C@H]([C@H](/C=C/[C@@H]3CC(C)=CCO3)OC)C[C@@H]3O[C@H]3[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9531,ML00004742,,,CC(C)CCCCCCCCCCCC[C@@H]1O[C@H]2O[C@@H](COC(=O)[C@H](C)[C@@H](CCCCCCCCCCCCC(C)C)O[C@@H]3O[C@H](COC(=O)[C@H]1C)[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@@H](O)[C@@H]2O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9532,ML00003359,,,CC1=C2C3=C4[C@](O)(C[C@H]5[C@@]6(C)[C@@H]7C[C@@H]7[C@@]7(O)COC(=O)/C=C(/C)COC(=O)CCC(=O)OCC8=C(C[C@@H]76)[C@@]35OC8=O)[C@H]3C[C@H]3[C@]4(C)[C@@H](O)[C@@]2(O)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9533,ML00002126,CHEMBL386626,,CCC[C@@H]1NC(=O)[C@@H](C(C)C)OC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9534,ML00009939,,,C/C1=C/C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CC(C)CCC1,standard_macrolactone,18.0,,,success,,9.0,"[3, 6, 10, 12, 13, 14, 15, 16, 17]",ring_size_18/standard/numbered/ML00009939_numbered.png,2026-03-19 06:58:59.353043
9535,ML00010449,,,CC(=O)OC1C(=O)OCC23CCC4(C)OC4C2OC2CC(OC(=O)/C=C\C=C\C(=O)OCCC1C)C3(C)C21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9536,ML00007598,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/C(=O)OC[C@H](O)/C(C)=C\C(=O)OC[C@@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9537,ML00010384,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC/C(C)=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9538,ML00009192,,,CCCC(=O)O[C@H]1C[C@@]23COC(=O)[C@@H](O)[C@H](C)CCO[C@@H]([C@H](C)O)/C=C\C=C\C(=O)O[C@@H]4C[C@@H](O[C@@H]2C=C1C)[C@@]1(CO1)[C@]43C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9539,ML00000988,CHEMBL580164,,CC1=CC(=O)OC[C@]23C[C@H](O)C(C)=C[C@H]2O[C@@H]2C[C@@H](OC(=O)C=CC=CC(=O)OCC1)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9540,ML00009959,,,COC(=O)[C@@H]1CCC[C@H]1[C@@H]1C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00009959_numbered.png,2026-03-19 06:58:59.436359
9541,ML00007419,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/C(=O)OCC[C@@]5(C)O[C@@H]5C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9542,ML00000039,CHEMBL1672609,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(nccc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9543,ML00010619,,,C/C=C\[C@H](C)[C@H]1O[C@]1(C)[C@@H](O)[C@H]1COC(=O)[C@H](O)[C@@H](OC)[C@H](C)C(=O)[C@H](C)[C@@H](O)/C(C)=C\[C@H](C)C(=O)C[C@H](O)[C@@H](C)C1=O,standard_macrolactone,18.0,,,success,,13.0,"[4, 5, 6, 7, 9, 10, 12, 13, 14, 15, 16, 17, 18]",ring_size_18/standard/numbered/ML00010619_numbered.png,2026-03-19 06:58:59.518542
9544,ML00009953,,,CC(O)C1/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4C[C@@H](C)[C@H](O)C[C@]4(COC(=O)C(O)C(C)CCO1)[C@]2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9545,ML00000690,CHEMBL1672602,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCc1cc(SC)c3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9546,ML00003377,,,COC(=O)/C(C)=C1/C(=O)[C@H](O)[C@@H]2C3=C1[C@]14OC(=O)C5=C1C[C@H]1[C@](O)(COC(=O)/C(C)=C\COC(=O)[C@@H](O)CC(=O)OC5)[C@H]5C[C@H]5[C@]1(C)[C@@H]4C[C@]3(OO)[C@H]1C[C@@H]21,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9547,ML00000308,CHEMBL224345,PAECILODEPSIPEPTIDE A,CC(C)=CCOc1ccc(C[C@H]2NC(=O)[C@@H](C)NC(=O)[C@@H](Cc3ccc(O)cc3)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)OC2=O)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9548,ML00009373,,,COC[C@@H]1NC(=O)[C@@H]2CCCNN2C(=O)[C@H](C(C)(C)C)OC(=O)[C@@H](C2(C)CC2)NC(=O)[C@@H]2C[C@@]3(O)c4ccc(Cl)c(Cl)c4N[C@H]3N2C(=O)[C@@H]([C@@H](O)CC(=O)O)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9549,ML00008810,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](CO)NC(=O)[C@@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9550,ML00008963,,,CCC(C)C1C(=O)OC(C(C)C)C(=O)N(C)C(C(C)CC)C(=O)OC(C(C)C)C(=O)N(C)C(C(C)C)C(=O)OC(C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9551,ML00007247,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)CNC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9552,ML00000750,CHEMBL1672591,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCC1)NC(=O)OCCCCCc1ccc3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9553,ML00007215,,,CC1CCOC(=O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4C=C(CO)CC[C@]4(COC(=O)C1O)[C@]2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9554,ML00009958,,,C/C(=C\c1csc(C)n1)[C@@H]1C/C=C\CCC[C@H](C)C[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,18.0,,,success,,9.0,"[3, 10, 12, 13, 14, 15, 16, 16, 17]",ring_size_18/standard/numbered/ML00009958_numbered.png,2026-03-19 06:58:59.658921
9555,ML00007221,,,C=C1CCC[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/c3csc(C)n3)C/C=C/[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9556,ML00004108,,,COC(=O)/C(C)=C1/C(=O)[C@@H](O)[C@@]2(C)C3=C([C@@H](O)[C@H]4[C@@]5(OC(=O)C6=C5C[C@H]5[C@@]4(C)[C@H]4C[C@H]4[C@]5(O)COC(=O)/C(C)=C\COC(=O)CCC(=O)OC6)[C@@H]31)[C@@H]1C[C@@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9557,ML00000076,CHEMBL1813267,SHIZUKAOL B,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C(C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C(C)=C/COC(=O)CCC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@H]31)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9558,ML00006484,,,CC[C@H]1[C@@H](O)[C@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)COC(c2ccccc2)(c2ccccc2)c2ccc(OC)cc2)OC(=O)/C(OC)=C/C(C)=C/[C@@H](C)[C@H]1O,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00006484_numbered.png,2026-03-19 06:58:59.754400
9559,ML00010027,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OC[C@H](O)/C(C)=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9560,ML00007383,,,C/C=C\C/C(C)=C\[C@H]1C/C=C\C=C/C[C@H](C)/C=C(/C)[C@@H](OC)C[C@@H](O)C[C@@H](O)CC(=O)O1,standard_macrolactone,18.0,,,success,,6.0,"[3, 10, 12, 13, 15, 17]",ring_size_18/standard/numbered/ML00007383_numbered.png,2026-03-19 06:58:59.809732
9561,ML00004932,,,C[C@H](O)CCCCC[C@@H](CCCCCCCCCCCCC[C@H]1CC(=O)OC[C@H]2O[C@@H](O[C@H](CCCCCCCCCCC[C@H](CCCCC[C@H](C)O)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)CC(=O)OC[C@H]3O[C@@H](O1)[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@@H](O)[C@@H]2O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9562,ML00002336,,,CCC(=O)C(CC)C(O)C(C)CC(C)C1OC(=O)CC2(O)CC=C(C)C(O2)/C(C)=C\CCCC(OC2CC(OC(N)=O)C(O)C(C)O2)/C=C\C(C)C(O)C1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9563,ML00011023,,,CC(C)/C=C/C=C/C[C@@H]1NC(=O)[C@H]2C[C@@H](O)CNN2C(=O)COC(=O)[C@](C)(CO)NC(=O)[C@@H]2CCCNN2C(=O)[C@H]2C[C@H](Cl)CNN2C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9564,ML00010202,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC(=O)[C@H](C)CC(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9565,ML00009218,,,CC[C@@H](C)[C@H]1C(=O)O[C@H](C)C(=O)N(C)[C@@H]([C@H](C)CC)C(=O)O[C@H](C)C(=O)N(C)[C@@H](CC2CCCCC2)C(=O)O[C@H](C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9566,ML00010982,,,C#CCOC(=O)[C@@H]1CCC[C@H]1[C@@H]1C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010982_numbered.png,2026-03-19 06:58:59.910350
9567,ML00009294,,,CC[C@H]1/C=C(/C)[C@@H](O)C/C=C\C=C(\C)C(=O)O[C@H](CC)C/C=C(C)\C=C(\C)[C@@H]1O[C@H]1OC(C)(C)[C@H](OC(C)=O)[C@@H](O)[C@@H]1O,standard_macrolactone,18.0,,,success,,8.0,"[3, 6, 8, 9, 10, 12, 13, 18]",ring_size_18/standard/numbered/ML00009294_numbered.png,2026-03-19 06:58:59.966528
9568,ML00004110,,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C([C@H]4C[C@H]42)[C@H](O)[C@H]2[C@@]4(C)[C@@H]5C[C@@H]5[C@@]5(O)COC(=O)/C=C(/C)COC(=O)CCC(=O)OCC6=C(C[C@@H]54)[C@@]2(OC6=O)[C@H]31,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9569,ML00009960,,,C/C1=C\[C@H](C)C[C@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)c(I)c2)N(C)C(=O)CNC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9570,ML00009956,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](Cc2ccc(O)c(I)c2)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9571,ML00010358,,,CC(O)C1C=CC=CC(=O)OC2CC3OC4C5OC5(C)CCC4(COC(=O)C4OC4(C)C(O)CO1)C2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9572,ML00002746,,,COC1CC/C=C(C)\C=C/C(OC2CC(NC(C)=O)C(O)C(C)O2)C(C)CC(OC)C2OC(O)(C(C)C(=O)OC1/C=C/C(C)=C/C(C)C(C)O)C(OC)C(O)C2C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9573,ML00010379,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@@H]([C@@H](C)O)OCC/C(C)=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9574,ML00009180,,,CC[C@@H](C)[C@H]1C(=O)O[C@H](Cc2ccc([N+](=O)[O-])cc2)C(=O)N(C)[C@@H]([C@H](C)CC)C(=O)O[C@H](C)C(=O)N(C)[C@@H](C)C(=O)O[C@H](C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9575,ML00010353,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OC[C@H](O)/C(C)=C\C(=O)OC[C@]2(C[C@H]1O)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9576,ML00009381,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)O)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00009381_numbered.png,2026-03-19 06:59:00.083445
9577,ML00000482,CHEMBL2206979,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(OCc4csc(C(C)C)n4)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9578,ML00009178,,,CC[C@@H](C)[C@H]1C(=O)O[C@H](C)C(=O)N(C)[C@@H]([C@H](C)CC)C(=O)O[C@H](C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)O[C@H](C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9579,ML00009952,,,CC1CC(=O)OC[C@]23C[C@@H](O)[C@H](C)C[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C\C(C(C)O)O[C@H](O)C1)[C@@]3(C)C21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9580,ML00010522,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)N[C@@H](CC(N)=O)C(=O)O)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010522_numbered.png,2026-03-19 06:59:00.157633
9581,ML00004149,,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C(C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C=C(/C)COC(=O)[C@@H](O)CC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@H]31)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9582,ML00000144,CHEMBL2206977,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(OCc4csc(C)n4)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9583,ML00006409,,,C/C=C/[C@H]1O[C@@](O)([C@H](C)C(O)C(C)[C@@H]2OC(=O)C(OC)=CC(C)=C[C@H](C)[C@H](O)[C@H](CC)[C@H](O)C(C)CC(C)=CC=C[C@H]2OC)C[C@@H](O[C@@H]2C[C@H](O)[C@@H](OC(N)=O)[C@H](C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00006409_numbered.png,2026-03-19 06:59:00.231948
9584,ML00008985,,,CC[C@H](C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9585,ML00002125,CHEMBL438998,,CCC[C@@H]1OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9586,ML00005560,,,CCC(=O)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)C[C@@H](C)[C@H]1OC(=O)C[C@@]2(O)CC=C(C)C(O2)C(C)=CCCC[C@H](O[C@H]2C[C@@H](OC(N)=O)[C@H](OC(C)=O)[C@@H](C)O2)C=C[C@H](C)C[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9587,ML00002797,,,C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@@H](CC)[C@@H](O)[C@H](C)C/C(C)=C\C=C/[C@@H]2OC)C[C@@H](OC(=O)/C=C/C(=O)O)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/ML00002797_numbered.png,2026-03-19 06:59:00.309487
9588,ML00007365,,,CC[C@H](C)[C@H]1C(=O)O[C@H](C)C(=O)N(C)[C@@H]([C@@H](C)CC)C(=O)O[C@H](C)C(=O)N(C)[C@@H](C)C(=O)O[C@@H](C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9589,ML00007678,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H](C[C@H](C)C(=O)O)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00007678_numbered.png,2026-03-19 06:59:00.364704
9590,ML00009254,,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)Sc2ccccc2)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00009254_numbered.png,2026-03-19 06:59:00.413725
9591,ML00007219,,,CC1CCOC(=O)/C=C/C=C\C(=O)OC2CC3OC4C5OC5(C)C(O)CC4(COC(=O)C1O)C2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9592,ML00010720,,,CCCCSC(=O)[C@@H]1CCC[C@H]1[C@@H]1C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/ML00010720_numbered.png,2026-03-19 06:59:00.468722
9593,ML00006341,,,CC[C@@H](C)[C@H]1OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]([C@H](C)CC)OC(=O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9594,ML00010306,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(O)c(I)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9595,ML00001334,CHEMBL2426323,,CO[C@@H]1C(=O)O[C@H](C)[C@H](C)/C=C(\C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1ccc(C)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9596,ML00010326,,,C/C(=C\c1csc(C)n1)[C@@H]1C/C=C\CCCC(C)C[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,18.0,,,success,,8.0,"[3, 10, 12, 13, 14, 15, 16, 17]",ring_size_18/standard/numbered/ML00010326_numbered.png,2026-03-19 06:59:00.534897
9597,ML00000840,CHEMBL195655,,C=C1CC(/C=C/C2CCCCC2)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@@H]3CC(C)=CCO3)C[C@@H]3O[C@H]3[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9598,ML00007282,,,C/C=C/C/C(C)=C/[C@H]1C/C=C\C=C/C[C@H](C)/C=C(/C)[C@@H](OC)C[C@@H](O)C[C@@H](O)CC(=O)O1,standard_macrolactone,18.0,,,success,,6.0,"[3, 10, 12, 13, 15, 17]",ring_size_18/standard/numbered/ML00007282_numbered.png,2026-03-19 06:59:00.581322
9599,ML00000736,CHEMBL591667,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC/C=C/c1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9600,ML00008967,,,CC[C@H](C)[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]([C@@H](C)CC)OC(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9601,ML00007177,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccc(O)c(I)c2)N(C)C(=O)CNC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9602,ML00003424,,,CC[C@@H](C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H]([C@H](C)CC)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](CC2CCCCC2)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9603,ML00009090,,,CCC(=O)[C@H](C)[C@H](O)[C@H](C)C[C@H](C)[C@@H]1OC(=O)C[C@]2(O)CC=C(C)[C@H](O2)/C(C)=C\CCC[C@H](O)/C=C\[C@@H](C)[C@@H](O)[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9604,ML00001166,CHEMBL389575,FIJIANOLIDE E,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)OC([C@@H](O)/C=C/[C@@H]3CC(C)=CC(=O)O3)C[C@@H]3O[C@H]3[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9605,ML00010041,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@@H](C)O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9606,ML00000143,CHEMBL2063087,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCCCc1nc3ccc(OC)cc3cc1O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9607,ML00010382,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\[C@H]([C@H](C)O)OCC/C(C)=C/C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9608,ML00000673,CHEMBL1672589,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCCCCCc1ccc3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9609,ML00000989,CHEMBL576350,,CC1=CC(=O)OC[C@]23CCC(C)=C[C@H]2O[C@@H]2C[C@@H](OC(=O)C=CC=CC(=O)OCC1)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9610,ML00004750,,,CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](C)O[C@H](O/C2=C/C=C/C[C@@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)[C@H](OC)[C@@H]1O,standard_macrolactone,18.0,,,success,,8.0,"[3, 6, 8, 9, 10, 12, 13, 18]",ring_size_18/standard/numbered/ML00004750_numbered.png,2026-03-19 06:59:00.704561
9611,ML00008893,,,CC(C)C[C@H]1C(=O)O[C@@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(C)C)C(=O)O[C@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9612,ML00000870,CHEMBL399265,BEAUVERICIN H3,CC(C)[C@H]1OC(=O)[C@H](Cc2cccc(F)c2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2cccc(F)c2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2cccc(F)c2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9613,ML00000827,CHEMBL1076535,PALMYRAMIDE A,CCC[C@H]1OC(=O)[C@H](C(C)C)NC(=O)[C@@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)OC(=O)[C@H](C)OC(=O)C1(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9614,ML00005149,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9615,ML00002423,,,C=CCCC[C@@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)OC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9616,ML00002827,,,CC[C@H](C)C[C@H](C)C[C@@H](C)/C=C(\C)[C@@H]1O[C@](O)([C@](C)(O)C(=O)N[C@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)CC(=O)N(C)CC(=O)NCC(=O)N(C)CC(=O)O[C@@H]2C(C)C)CC[C@H]1OC,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9617,ML00010554,,,CC[C@H](C)[C@]1(C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9618,ML00006127,,,CC[C@H](C)[C@@H]1NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)CNC(=O)CCCC(C)C)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9619,ML00003695,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9620,ML00003910,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(OC)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(C)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9621,ML00005060,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9622,ML00010704,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2[C@@H](C)CCN2C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H]([C@@H](C)CC)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9623,ML00009752,,,C=C1C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@@H](c2ccc(O)cc2)CC(=O)O[C@@H](C)C[C@@H](C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9624,ML00008997,,,CC(C)CCCCC(C)(C)CCC[C@@H]1CC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9625,ML00009716,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9626,ML00004392,,,C/C=C/C1CC2C(=O)OC(C)C(NC(=O)C(CC3CC3[N+](=O)[O-])NC(=O)c3ccc(Cl)n3O)C(=O)NC(C(C)c3ccccc3)C(=O)NC(CC3CC3[N+](=O)[O-])C(=O)NC(C(C)c3ccccc3)C(=O)NC(C(C)CC)C(=O)N2C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9627,ML00004347,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](O)COS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9628,ML00005906,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](O)Cc2ccc(O)cc2)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9629,ML00005159,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9630,ML00006495,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)[O-])OC)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9631,ML00005126,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)CCCC(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9632,ML00010891,,,C=CC[C@@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9633,ML00000834,CHEMBL2204319,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCC/C=C/c1ccc3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9634,ML00006315,,,CC(C)[C@@H]1NC(=O)[C@@H]2CSCSC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)c3cnc4ccccc4n3)COC1=O)C(=O)N[C@@H](C(C)C)C(=O)OC[C@@H](NC(=O)c1cnc3ccccc3n1)C(=O)N[C@@H](C)C(=O)N2,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
9635,ML00003690,,,CCCCCC[C@@H]1CC[C@@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@H]3C(=O)N(O)[C@@H](COC)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)O[C@@H]2C)O[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9636,ML00008151,,,O=C1CCCCCCCCCCC(=O)OCCOCCO1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9637,ML00010547,,,CCC[C@H]1NC(=O)c2csc(n2)[C@H](C)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C)OC(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9638,ML00010593,,,C/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OCCc3ccc(cc3)Oc3cc(ccc3O)CCOC(=O)C[C@H]21,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
9639,ML00010160,,,CCC[C@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9640,ML00009479,,,CC[C@@H]1NC(=O)[C@@H](C)C/C(C)=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9641,ML00004766,,,CC(C)[C@H]1C(=O)OC[C@@H](NC(=O)c2cnc3ccccc3n2)C(=O)N[C@@H](C)C(=O)N(C)[C@H]2CSCSC[C@@H](C(=O)N1C)N(C)C(=O)[C@H](C)NC(=O)[C@H](NC(=O)c1cnc3ccccc3n1)COC(=O)[C@H](C(C)C)N(C)C2=O,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
9642,ML00008840,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9643,ML00005894,,,C/C=C\C=C\C=C/C=C/C=C\C=C/C=C/C=C/C(=O)N(C)[C@@H]1C(=O)N[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9644,ML00005189,,,C/C=C1\NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](CCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9645,ML00005127,,,C/C=C1\NC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9646,ML00007076,,,C/C1=C/[C@@H](O)C[C@H](C)CCO[C@@H]2O[C@H](CO[C@@H]3OC[C@](O)(COC1=O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9647,ML00005939,,,CCCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]2CC[C@@H](O)N(C2=O)[C@@H]([C@@H](C)O)C(=O)N(C)[C@@H](Cc2ccc(O)c(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C)[C@@H](C)O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9648,ML00006134,,,CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCCN(C)C)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9649,ML00002834,,,C/C=C1/[C@H](O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O[C@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3O)[C@@H]2O)OC=C2C(=O)OCCc3ccc(cc3)Oc3cc(ccc3O[C@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3O)CCOC(=O)C[C@@H]21,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
9650,ML00005775,,,C=CC[C@@H]1/C=C(/C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H]([C@@H](C)[C@H](O)/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)CC1=O)[C@H](C)C[C@@H]2OC,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9651,ML00000654,CHEMBL1532000,,CO[C@@H]1COC(=O)[C@H]2CCCN2C(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)CCC[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9652,ML00010158,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9653,ML00001644,CHEMBL1159823,PROTEOLYTIC ENZYME INHIBITOR,CC(C)C[C@H]1C(=O)N(C)[C@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](O)COS(=O)(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]2CC[C@H](O)N1C2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9654,ML00005156,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9655,ML00005188,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9656,ML00000419,CHEMBL3823434,,COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc2ccc3cc(-c4ccc5c(c4)OCCCCCCOC(=O)N[C@@H](C(C)C)C(=O)N4CCC[C@H]4c4ncc-5[nH]4)ccc3c2[nH]1)C(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9657,ML00004935,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(F)(F)F)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9658,ML00002582,,,CC(C)[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCCCN=C(N)N)[C@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@H](C)O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9659,ML00001467,CHEMBL402405,MICROPEPTIN T2,CCCCCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](Cc2ccccc2)C(=O)N(C)[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9660,ML00010870,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9661,ML00005167,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)c2ccc(C)cc2)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9662,ML00007027,,,COc1cc(O)c2c(c1)/C=C/CC(=O)NCCCCNC(=O)CCC[C@H](C)OC2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9663,ML00005565,,,CC(C)CC1CCC(O)(C(C)(O)C(=O)NC2C(=O)N3NCCCC3C(=O)N(O)C(C)C(=O)N(C)C(Cc3ccccc3)C(=O)N3NCCCC3C(=O)NC(CO)C(=O)OC2C(C)C)OC1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9664,ML00007127,,,C/C(Br)=C\[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C=C/C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9665,ML00003470,,,CO[C@@H]1/C=C\C=C/C[C@H](OC)c2coc(n2)C[C@@H](O)C(C)(C)[C@@H](C[C@H](OC)[C@H](C)CCC(=O)[C@H](C)[C@H](C/C=C/N(C)C=O)OC)OC(=O)C[C@H](O)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9666,ML00010781,,,CCCCC(C)C1CC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9667,ML00005139,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9668,ML00009395,,,CO[C@]1(C[C@@H]2C(=O)N[C@@H](c3ccc(O)cc3)CC(=O)O[C@@H](C)C[C@@H](C)/C=C(/C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N2C)OC(=O)Nc2ccccc21,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9669,ML00000321,CHEMBL396293,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CCCC(C)C)C(C)C)[C@H](C)OC(C)=O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9670,ML00002641,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCCNC)NC(=O)[C@@H](NC(=O)[C@H](O)COS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9671,ML00002390,,,CC[C@H](C)[C@H]1NC(=O)C(Cc2ccc(OC)cc2)NC(=O)[C@@H](NC(=O)[C@@H](NC=O)[C@H](C)CC)[C@@H](C)OC(=O)[C@H](C)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CCCNN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9672,ML00009905,,,CC(C)[C@@H]1OC(=O)[C@@H](C)N(O)C(=O)[C@@H]2CCCNN2C(=O)CNC(=O)[C@H](C)N(O)C(=O)[C@H]2CCCNN2C(=O)[C@H]1NC(=O)[C@@](C)(O)CCCc1ccccc1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9673,ML00001261,CHEMBL1076833,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](CO)OS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9674,ML00005082,,,C/C=C1\NC(=O)[C@H](CCC2CCCCC2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9675,ML00002971,,,CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2CC(=O)CCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9676,ML00005748,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)O)OC)C(C)C)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9677,ML00009285,,,C=C/C=C(\C)[C@H](O)CC[C@@H](C)/C=C/[C@H]1CC[C@H](C)C(=O)CC(=O)N[C@@H](C)CCC(=O)[C@H](C)[C@@H](O)[C@@H](C)/C=C(/C)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9678,ML00000933,CHEMBL256304,MICROPEPTIN SD944,CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H]([C@@H](C)CC)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9679,ML00000976,CHEMBL1077010,MOLASSAMIDE,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CCC)[C@@H](C)O)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9680,ML00010065,,,CCC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(O)CCl)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9681,ML00006086,,,CCCCCCCC1OC1C(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc2c[nH]c3ccc(O)cc23)C(=O)N[C@@H](c2ccc(O)cc2)C(=O)NCC(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9682,ML00003871,,,C=C1NC(CC(C)C)C(=O)N[C@H](C(C)C)C(=O)N2NCCCC2C(=O)CC(CC(C)C)C(=O)N2NCCCC2C(=O)OC(C)[C@H]1NC(=O)[C@@H](NC=O)[C@@H](C)CC,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9683,ML00001460,CHEMBL519769,MICROPEPTIN 88 E,CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@@H]1C)C(=O)O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9684,ML00001260,CHEMBL1076830,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](O)CO)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9685,ML00002583,,,CC(C)[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@H](NC(=O)C[C@H](O)CCCCCCCCCCCCNC(=N)N)[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9686,ML00009349,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9687,ML00009669,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9688,ML00000814,CHEMBL3577228,,CCCCCC/C=C\CCC[C@@H]1CC(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9689,ML00006306,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)[O-])OC)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9690,ML00010992,,,CC(=O)O[C@]1(C)CC(=O)OC[C@@H]2CC(C)=C[C@H]3O[C@@H]4C[C@@H](OC(=O)/C=C\C=C/[C@@H]([C@H](C)O)OC[C@@H]1O)[C@](C)([C@@H]32)[C@@]41CO1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9691,ML00004787,,,CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2CC(=O)[C@H](CS[C@@H]3CN4CCC3CC4)CN2C(=O)[C@H](Cc2ccc(N(C)C)cc2)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9692,ML00000823,CHEMBL539419,ISARIDIN C2,CC(C)CC1OC(=O)CCNC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2C(C)CCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9693,ML00006367,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)O)OC)C(C)C)[C@@H](C)OC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9694,ML00000865,CHEMBL1783105,VERAGUAMIDE A,CC[C@H](C)[C@@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@@H](C)[C@@H](CCCC#CBr)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9695,ML00004128,,,C#CCCC[C@H]1OC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9696,ML00009336,,,C/C1=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@H](Cc2ccc(O)c(Br)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9697,ML00006517,,,CCCCCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H]2CC[C@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9698,ML00004958,,,C/C=C1\NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9699,ML00008839,,,COc1ccc([C@H]2CC(=O)O[C@@H](C)C[C@@H](C)/C=C(\C)CCC(=O)N[C@@H](C)C(=O)N[C@H](Cc3c(Br)[nH]c4ccccc34)C(=O)N2)cc1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9700,ML00005169,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)Cc2cc(F)cc(F)c2)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9701,ML00006168,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)[O-])OC)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9702,ML00009651,,,CCC[C@H]1NC(=O)c2csc(n2)[C@H](C)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](C)OC(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9703,ML00000760,CHEMBL1078916,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2OC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](O)CO)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9704,ML00001371,CHEMBL3974971,,CCCCCC[C@H](C)[C@@H]1CC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9705,ML00010780,,,CCCCCCC1CC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9706,ML00003925,,,CCC(C)CC1CCC(O)(C(C)(O)C(=O)NC2C(=O)N3NCCCC3C(=O)N3NCCCC3C(=O)CCC(=O)N(C)CC(=O)N(C)CC(=O)OC2C(C)C)OC1CC,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9707,ML00001461,CHEMBL254975,PLANKTOPEPTIN BL1125,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)N(C)C(=O)[C@H]([C@@H](C)O)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCc2ccc(O)cc2)NC(=O)[C@@H](O)CO)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9708,ML00003585,,,CC[C@@H](C)[C@H]1NC(=O)[C@@H](NC(C)=O)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(OC)cc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9709,ML00010988,,,CC[C@H]1NC(=O)c2csc(n2)[C@H](C)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C)OC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9710,ML00005157,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9711,ML00010319,,,C=CCC1OC(=O)CCNC(=O)C(C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(C(C)C)NC(=O)C2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9712,ML00000527,CHEMBL1923809,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCNCc2ccc(F)c(C)c2)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9713,ML00000520,CHEMBL388682,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCNCCCCCC)NC(=O)[C@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CCCC(C)C)C(C)C)[C@H](C)O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9714,ML00009674,,,C=C1C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@@H](c2ccc(O)cc2)CC(=O)O[C@@H](C)C[C@@H](C)[C@H]1O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9715,ML00009758,,,C/C1=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3cc(Br)ccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9716,ML00005062,,,C/C=C1\NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9717,ML00000862,CHEMBL1783473,VERAGUAMIDE G,C=CCCC[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9718,ML00003309,,,CC[C@H](C)[C@H]1NC(=O)[C@@H](NC(C)=O)[C@@H](C)OC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](Cc2ccc(OC)cc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9719,ML00005480,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@@H](C)C(=O)N3NC[C@H](O)C[C@@H]3C(=O)N3CC[C@@](C)(O)[C@@H]3C(=O)N(O)[C@@H](C(C)C)C(=O)O[C@H]2C(C)C)O[C@@H]1CC,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9720,ML00003089,,,CC[C@H](C)[C@H]1NC(=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCCCN=C(N)N)[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9721,ML00000852,CHEMBL1783470,VERAGUAMIDE D,C#CCCC[C@H]1OC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9722,ML00000864,CHEMBL1783107,VERAGUAMIDE C,C#CCCC[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9723,ML00009964,,,C=CC[C@@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9724,ML00006126,,,CC[C@H](C)[C@H]1C(=O)N[C@@H]([C@H](O)CC)C(=O)N(C)[C@H](Cc2c[nH]c3ccc(OC)cc23)C(=O)O[C@H](C)[C@@H](NC(=O)[C@H](NC=O)C(C)C)C(=O)N[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@@H](C)C(=O)N1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9725,ML00005124,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9726,ML00003746,,,CCCCCCC[C@@H]1CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9727,ML00001915,CHEMBL3964509,,CCCCCC[C@H](C)[C@@H]1CC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9728,ML00009484,,,C=C1C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](CC2(OC)OC(=O)Nc3ccccc32)C(=O)N[C@@H](c2ccc(O)cc2)CC(=O)O[C@@H](C)C[C@@H](C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9729,ML00011027,,,CO[C@H]1C[C@H]2O[C@H]1/C=C(/C)[C@H](O)C/C=C\C=C(\C)C(=O)[C@@H](C)/C=C(/C)C(=O)O[C@H](/C=C/[C@@H](OC)[C@H](C)O)[C@@H]2C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9730,ML00003881,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(OC)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(OC)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9731,ML00005079,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)OC(=O)C(F)(F)F)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9732,ML00005602,,,CC(C)[C@H]1NC(=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCCCNC(=N)N)[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9733,ML00009394,,,CO[C@@]1(C[C@@H]2C(=O)N[C@@H](c3ccc(O)cc3)CC(=O)O[C@@H](C)C[C@@H](C)/C=C(/C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N2C)OC(=O)Nc2ccccc21,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9734,ML00009967,,,C=CCC1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9735,ML00009412,,,CC[C@H](C)[C@H]1C(=O)N(C)[C@@H](CC(C)C)C(=O)NCCC(=O)O[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)N1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9736,ML00004956,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9737,ML00003793,,,C#CCCC[C@H]1OC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)C)OC(=O)[C@@H]([C@H](C)CC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9738,ML00010594,,,C/C=C1/[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OCCc3ccc(cc3)Oc3cc(ccc3O)CCOC(=O)C[C@H]21,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
9739,ML00002854,,,CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@H](C)OC(=O)[C@H](c2ccccc2)NC(=O)[C@H]2CC(=O)CCN2C(=O)[C@H](Cc2ccc(N(C)C)cc2)NC(=O)[C@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9740,ML00000172,CHEMBL1361449,,CO[C@@H]1COC(=O)C/C=C\[C@@H](C)[C@H](OC)COC(=O)[C@H](COCc2ccccc2)NC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9741,ML00000779,CHEMBL1076838,CYANOPEPTOLIN S,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](O)COS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9742,ML00005137,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9743,ML00005073,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)C(C)C)[C@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9744,ML00003262,,,CC(C)C[C@@H]1OC(=O)CCNC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9745,ML00000977,CHEMBL2062540,STIGONEMAPEPTIN,C/C=C1/NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CCCN2C=O)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9746,ML00009751,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)/C=C(/c2ccc(O)c(O)c2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9747,ML00010747,,,CCCCCC[C@H]1OC(=O)CNC(=O)[C@@H](CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9748,ML00005185,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)(C)O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9749,ML00010748,,,CCCCCC[C@H](C)[C@@H]1CC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9750,ML00010617,,,CCCCCC[C@H]1OC(=O)CNC(=O)[C@@H]([C@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9751,ML00000910,CHEMBL243070,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CCCC(C)C)C(C)C)C(C)=O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9752,ML00000230,CHEMBL1172449,CYANOPEPTOLIN 1020,CCCCCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](Cc2ccccc2)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9753,ML00009386,,,CC1=C[C@@H]2[C@@H]([C@@H]3[C@H]1/C=C\C=C\C=C/[C@@H](O)[C@H](C)[C@H](O)C/C=C(C)/C=C/C(=O)O[C@H]3c1ccc(O)cc1)C(C)(C)C[C@@]2(C)O,standard_macrolactone,19.0,,,success,,5.0,"[3, 12, 13, 14, 17]",ring_size_19/standard/numbered/ML00009386_numbered.png,2026-03-19 06:59:01.954486
9754,ML00005004,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9755,ML00005080,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)Cc2ccc(C(F)(F)F)cc2)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9756,ML00001366,CHEMBL1078517,ITRALAMIDE A,CC(CC(=O)N(C)[C@@H]1C(=O)N(C)[C@@H](C(C)C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](C)C(=O)N(C)[C@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)O[C@@H]1C)C(Cl)Cl,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9757,ML00005057,,,CC(NC=O)C(=O)NC(Cc1ccc(Br)cc1)C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)NC(CC1(O)C(=O)Nc2ccccc21)C(=O)NC(CCCNC(=N)N)C(=O)NC(CS(=O)(=O)O)C(=O)NC1C(=O)N(C)C(CCC(N)=O)C(=O)NC(Cc2ccccc2)C(=O)NC(C(C)O)C(=O)NC(CC(N)=O)C(=O)N(C)CC(=O)OC1C)C(C)(C)C)C(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9758,ML00003436,,,CC[C@H]1O[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@H]3C(=O)N(O)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)O[C@@H]2C(C)C)CC[C@@H]1CCC(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9759,ML00000400,CHEMBL508049,LYNGBYABELLIN B,CC(C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CSC(=N2)[C@H](C(C)(C)O)OC(=O)C(C)(C)[C@H](CCCC(C)(Cl)Cl)OC(=O)c2csc1n2,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9760,ML00009754,,,C/C1=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9761,ML00010064,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](C[C@H](O)CCl)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9762,ML00004133,,,CCC[C@@H]1OC(=O)CNC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)NC(=O)C1(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9763,ML00004836,,,CCCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9764,ML00000905,CHEMBL3814608,,CC(C)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(Br)cc1)NC(=O)[C@@H](C)NC=O)C(=O)N[C@H](C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CS(=O)(=O)O)C(=O)N[C@@H]1C(=O)N(C)[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N(C)CC(=O)O[C@@H]1C)C(C)(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9765,ML00008841,,,C/C1=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9766,ML00005087,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9767,ML00006068,,,CC[C@H](C)[C@H]1C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](O)Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]2CC[C@@H](O)N1C2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9768,ML00006232,,,CCCCCC(=O)NC(CCC(=O)[O-])C(=O)NC1C(=O)NC(CCC[NH+]=C(N)N)C(=O)NC2CCC(O)N(C2=O)C(Cc2ccccc2)C(=O)N(C)C(Cc2ccc(O)cc2)C(=O)NC(C(C)C)C(=O)OC1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9769,ML00010016,,,CC[C@H](C)[C@@H]1NC(=O)CNC(=O)c2csc(n2)[C@H](C(C)C)OC(=O)C(C)(C)[C@H](CCCC(C)(Cl)Cl)OC(=O)c2csc1n2,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9770,ML00005058,,,CC(NC=O)C(=O)NC(Cc1ccccc1)C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCNC(=N)N)C(=O)NC(CS(=O)(=O)O)C(=O)NC1C(=O)N(C)C(CCC(N)=O)C(=O)NC(Cc2ccccc2)C(=O)NC(C(C)O)C(=O)NC(CC(N)=O)C(=O)N(C)CC(=O)OC1C)C(C)(C)C)C(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9771,ML00005854,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](C[C@H]2C=C[C@H](O)CC2)NC(=O)[C@@H](NC(=O)CC[C@H](N)C(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9772,ML00009896,,,CCC[C@H]1NC(=O)CNC(=O)[C@@H](Cc2ccc(OC)cc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9773,ML00005165,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)C2CCC(C)CC2)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9774,ML00010727,,,CCCCCC[C@H]1OC(=O)CNC(=O)[C@H]([C@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9775,ML00005178,,,CC[C@@H](C)[C@@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]1CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(=O)N[C@H]1C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)O[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9776,ML00003586,,,CC[C@H](C)[C@H]1NC(=O)[C@@H](NC(C)=O)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(OC)cc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9777,ML00002985,,,CCC1NC(=O)C(NC(=O)c2ncccc2O)C(C)OC(=O)C(c2ccccc2)NC(=O)C2CC(=O)CCN2C(=O)C(Cc2ccccc2)N(C)C(=O)C2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9778,ML00004760,,,CC(C)[C@H]1C(=O)OC[C@@H](NC(=O)c2cnc3ccccc3n2)C(=O)N[C@@H](C)C(=O)N(C)[C@H]2CS(=O)(=O)CS(=O)(=O)C[C@@H](C(=O)N1C)N(C)C(=O)[C@H](C)NC(=O)[C@H](NC(=O)c1cnc3ccccc3n1)COC(=O)[C@H](C(C)C)N(C)C2=O,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
9779,ML00002826,,,CCC(C)CC(C)CC(C)/C=C(\C)C1OC(O)(C(C)(O)C(=O)NC2C(=O)N3NCCCC3C(=O)N(O)CC(=O)N(C)CC(=O)NCC(=O)N(C)CC(=O)OC2C(C)C)CCC1OC,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9780,ML00003457,,,CC[C@H](C)[C@H]1C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)[C@H](O)COS(=O)(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]2CC[C@@H](O)N1C2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9781,ML00000203,CHEMBL589395,,CC[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9782,ML00003718,,,CC(C)[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](NC(=O)CCCCCCCCCCCNC(=N)N)[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9783,ML00001543,CHEMBL554919,MICROPEPTIN 88 C,CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@@H]1C)C(=O)O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9784,ML00010546,,,CCC[C@H]1NC(=O)c2csc(n2)[C@H](C)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](C)OC(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9785,ML00001127,CHEMBL227907,ISARIDIN E,CC(C)CC1OC(=O)CCNC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9786,ML00010548,,,CC1NC(=O)c2csc(n2)[C@H](C)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)OC(=O)C1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9787,ML00006008,,,CC[C@H]1NC(=O)[C@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@H](c2ccccc2)NC(=O)[C@H]2CC(=O)[C@H](O)CN2C(=O)[C@H](Cc2ccc(N(C)C)cc2)N(C)C(=O)[C@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9788,ML00005145,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]2CCCN2C(=O)CCCC(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9789,ML00005162,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9790,ML00000078,CHEMBL252952,LYNGBYASTATIN 4,C/C=C1\NC(=O)[C@@H](NC(=O)[C@H](CCc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@H](O)COS(=O)(=O)O)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9791,ML00002148,,,CC(C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](NC(=O)[C@H](O)COS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9792,ML00005183,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](CCCN)NC(=O)CCCC(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9793,ML00005689,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CCC)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9794,ML00005148,,,C/C=C1\NC(=O)[C@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9795,ML00010130,,,CO[C@H]1C[C@H]2O[C@H]1/C=C(/C)[C@H](O)C/C=C\C=C(\C)C(=O)[C@@H](C)/C=C(/C)C(=O)O[C@H](/C=C/[C@H]1O[C@@H]1C)[C@@H]2C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9796,ML00005636,,,CC[C@H](C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H]1C(=O)N[C@H](CC(C)C)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](CC(C)C)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@@H](CO)C(=O)O[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9797,ML00010570,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCN2C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9798,ML00006128,,,CC[C@H](C)[C@@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)CNC(=O)CCCC(C)C)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9799,ML00004831,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H]([C@H](C)O)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCc2ccc(O)cc2)NC(=O)[C@H](O)CO)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9800,ML00005701,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@@H](O)COP(=O)(O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9801,ML00006446,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)O)OC)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9802,ML00005675,,,CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9803,ML00005168,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)c2ccc3c(c2)OCO3)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9804,ML00005063,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCCCCCCCC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9805,ML00007256,,,CC(/C=C/CCCO)=C\[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C#CC(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9806,ML00000884,CHEMBL398725,LYNGBYASTATIN 5,C/C=C1\NC(=O)[C@@H](NC(=O)[C@H](CCc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@H](O)CO)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9807,ML00001521,CHEMBL397703,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCNCc2ccc(F)cc2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CCCC(C)C)C(C)C)[C@H](C)O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9808,ML00005093,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN(Cc2ccc(F)cc2)Cc2ccc(F)cc2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CCCC(C)C)C(C)C)[C@H](C)O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9809,ML00002857,,,C[C@@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@H](C)OC(=O)[C@@H](c2ccccc2)NC(=O)[C@H]2CC(=O)CCN2C(=O)[C@H](Cc2ccc(N(C)C)cc2)N(C)C(=O)[C@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9810,ML00010591,,,C/C=C1\C(OC2OC(CO)C(O)C(O)C2O)OC=C2C(=O)OCCc3ccc(O)c(c3)Oc3ccc(cc3)CCOC(=O)CC21,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
9811,ML00005056,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](CC2CCCCC2)NC(=O)CCCC(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9812,ML00004973,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9813,ML00009481,,,CC[C@@H]1NC(=O)[C@@H](C)C/C(C)=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9814,ML00004309,,,C=CCCC[C@H]1OC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9815,ML00001445,CHEMBL556534,MICROPEPTIN 88 N,CCCC(=O)N[C@@H](CC(C)C)[C@@H](CCC(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@@H]1C)C(=O)O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9816,ML00005143,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCCC(C)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9817,ML00003441,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@@H](C)C(=O)N[C@@H](C)C(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9818,ML00005907,,,CC(C)CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1COC(=O)CNC(=O)[C@@H]([C@H](C)O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9819,ML00000780,CHEMBL1078914,,CC[C@H](C)[C@H]1C(=O)N(C)[C@@H](Cc2ccc(OC)c(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)[C@@H](CO)OS(=O)(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]2CC[C@@H](O)N1C2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9820,ML00005734,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)[O-])OC)C(C)C)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9821,ML00009591,,,C#CCCC[C@@H]1OC(=O)[C@@H](C(C)C)N(C)C(=O)[C@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9822,ML00005934,,,CC(C)C[C@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)C(C)C)[C@H](C)OC(=O)[C@H](CO)NC(=O)[C@@H]([C@H](C)O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9823,ML00009963,,,C=CCC1OC(=O)CCNC(=O)C(C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(C(C)CC)NC(=O)C2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9824,ML00005147,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCCC(C)(F)F)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9825,ML00002458,,,CC[C@H](C)[C@H]1NC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC=O)C(C)C)[C@@H](C)OC(=O)[C@H](C)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CCCNN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9826,ML00007075,,,C/C1=C/CC[C@H](C)CCO[C@@H]2O[C@H](CO[C@H]3OC[C@](O)(COC1=O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9827,ML00006580,,,C/C=C(\C)C(=O)[C@@H](C)/C=C(\C)[C@H]1O[C@@](O)([C@@](O)(CC)C(=O)N[C@@H]2C(=O)N3NCCC[C@H]3C(=O)N(O)[C@@H](C)C(=O)N(C)[C@H](C)C(=O)N3NCCC[C@@H]3C(=O)N[C@@H]([C@H](C)O)C(=O)O[C@H]2C(C)C)CC[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9828,ML00004247,,,CCCCC[C@H]1OC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9829,ML00004835,,,CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)N[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@@H]1C)C(=O)O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9830,ML00005140,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9831,ML00000799,CHEMBL119201,,CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@@H]2OC(=O)c3cccc(c3)/C=C/COC(=O)N[C@@H](C=C(C)C)[C@@H](O)C(=O)O[C@H]3C[C@]2(O)C(C)(C)C1=C3C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9832,ML00002424,,,C=CCCC[C@@H]1OC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9833,ML00009027,,,CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)OC(=O)CCNC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9834,ML00007342,,,COC/C=C/C=C/C(C)=C/[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C=C\C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9835,ML00006579,,,C/C=C(\C)C(=O)[C@@H](C)/C=C(\C)[C@H]1O[C@@](O)([C@@](O)(CC)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@@H](C)C(=O)N(C)[C@H](C)C(=O)N3NCCC[C@H]3C(=O)N[C@H]([C@H](C)O)C(=O)O[C@H]2C(C)C)CC[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9836,ML00005144,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9837,ML00005163,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9838,ML00007246,,,CC(/C=C/C=C/CO)=C\[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C=C\C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9839,ML00005676,,,CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]2CC[C@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9840,ML00009038,,,CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)OC(=O)CCNC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9841,ML00008944,,,CCCCCCCC[C@H]1OC(=O)CNC(=O)[C@@H]([C@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9842,ML00010126,,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@@H](/C=C/[C@@H]3CC(C)=CCO3)[C@@H](O)C[C@@H]3O[C@H]3[C@@H](O)C1)O2,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9843,ML00007428,,,CC(C)C[C@@H]1NC(=O)OCCCc2cccc(c2)C(=O)O[C@H]2C=CC(=O)N3C[C@H](C[C@H]23)OC(=O)[C@@H]1O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9844,ML00004864,,,CC[C@H](C)[C@@H](C(=O)N[C@@H]1C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](C)C(=O)N(C)[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)c1ccccc1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9845,ML00010873,,,CC[C@H](C)[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H]([C@H](C)CC)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9846,ML00000967,CHEMBL563769,MICROPEPTIN A,CCCCCCCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9847,ML00010592,,,C/C=C1/[C@H](O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O)OC=C2C(=O)OCCc3ccc(cc3)Oc3cc(ccc3O)CCOC(=O)C[C@H]21,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
9848,ML00001982,CHEMBL2041196,JASPAMIDE K,C/C1=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9849,ML00005177,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9850,ML00005700,,,C/C=C1\NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)OC)C(C)C)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H](Cc2ccccc2)N2C(=O)[C@H](CC=C2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9851,ML00009970,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](C[C@@H]2CO2)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9852,ML00001546,CHEMBL558554,MICROPEPTIN 88 D,CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)N[C@@H]1C(=O)N[C@@H](C[C@H]2C=C[C@H](O)CC2)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@@H]1C)C(=O)O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9853,ML00000845,CHEMBL1783471,VERAGUAMIDE E,C#CCCC[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)OC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9854,ML00004482,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@H](CCc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@H](O)COS(=O)(=O)O)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2OC)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9855,ML00001442,CHEMBL403653,MICROPEPTIN T1,CCCCCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](Cc2ccccc2)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9856,ML00000688,CHEMBL601195,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCC/C=C/c1cccc3c1CN(CC3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9857,ML00007126,,,C/C(Br)=C\[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C=C\C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9858,ML00000850,CHEMBL599903,,CCCCCCC1CCC(O)(C(C)(O)C(=O)NC2C(=O)N3NCCCC3C(=O)N(O)C(COC)C(=O)NCC(=O)N3NCCCC3C(=O)N(O)C(C)C(=O)OC2C)OC1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9859,ML00005151,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)c2ccccc2)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9860,ML00010700,,,Cc1oc(=O)oc1COC(=O)N1C[C@@H]2C[C@H]1C(=O)Nc1cccc(c1)C(=O)OCc1oc(=O)oc1COC(=O)C1=C(S2)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9861,ML00005105,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)[C@H]2CC[C@H]3[C@@H]4CC[C@@H]5C[C@H](OC(=O)C(F)(F)F)CC[C@]5(C)[C@H]4CC[C@@]32C)C(C)C)[C@@H](C)OC(=O)C(F)(F)F)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9862,ML00004972,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCO)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9863,ML00006249,,,CCCCCCCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9864,ML00003132,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](O)CO)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9865,ML00001459,CHEMBL254380,MICROPEPTIN 88E,CCCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9866,ML00000906,CHEMBL3815164,,CC(C)[C@H](NC(=O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(Br)cc1)NC(=O)[C@@H](C)NC=O)C(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CS(=O)(=O)O)C(=O)N[C@@H]1C(=O)N(C)[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N(C)CC(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9867,ML00001611,CHEMBL256255,MICROPEPTIN SF909,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](CC(C)C)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](O)Cc2ccc(O)cc2)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9868,ML00001584,CHEMBL487379,TASIPEPTIN A,CCCC(=O)N[C@H](C(=O)N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C)C(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9869,ML00000393,CHEMBL3126417,,CC(/C=C/C(C)=C/[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C=C\C(=O)O1)=C\CN1CCOCC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9870,ML00009393,,,CO[C@@]1(C[C@H]2C(=O)N[C@@H](c3ccc(O)cc3)CC(=O)O[C@@H](C)C[C@@H](C)/C=C(/C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N2C)OC(=O)Nc2ccccc21,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9871,ML00002157,,,CC(C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](O)COS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9872,ML00005114,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](CCC2CCCCC2)NC(=O)[C@@H](NC(=O)[C@@H](CC2CCCCC2)NC(=O)CCCC(C)C)[C@@H](C)O)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9873,ML00005186,,,C/C=C1\NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9874,ML00004965,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)COC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9875,ML00001468,CHEMBL254782,OSCILLAPEPTIN E,CC[C@H](C)[C@H]1C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@H](C)CC)C(=O)O[C@H](C)[C@H](NC(=O)[C@@H](CCc2ccc(O)cc2)NC(=O)[C@@H](COS(=O)(=O)O)OC)C(=O)N[C@@H](CCc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N1C2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9876,ML00001906,CHEMBL3126414,,CC(/C=C/CCCO)=C\[C@@H]1Cc2nc(cs2)[C@@H](C)C[C@@H](NC(=O)OC(C)(C)C)CC(=O)O[C@@H](C)C/C(C)=C/C#CC(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9877,ML00000184,CHEMBL436840,SYMPLOCAMIDE A,CCCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H]([C@@H](C)CC)C(=O)N(C)[C@@H](Cc2ccc(OC)c(Br)c2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9878,ML00006299,,,C/C=C(\C)C(=O)C(/C=C(\C)C1OC(O)(C(O)(CC)C(=O)NC2C(=O)N3NCCCC3C(=O)N(O)C(COC)C(=O)N(C)C(C)C(=O)N3NCCCC3C(=O)NC(C(C)O)C(=O)OC2C(C)C)CCC1C)CC,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9879,ML00004954,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9880,ML00000859,CHEMBL3577226,,CCCCCCCCC[C@@H]1CC(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9881,ML00009961,,,C=CC[C@@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)CC)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9882,ML00007253,,,CC(/C=C/CCCO)=C\[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C=C\C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9883,ML00009907,,,CC(C)[C@H]1C(=O)N[C@H](C)C(=O)N(C)[C@@H](C)C(=O)N(C)[C@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)O[C@H](C)[C@H](N(C)C(=O)C[C@H](C)C(Cl)Cl)C(=O)N1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9884,ML00001496,CHEMBL402404,OSCILLAPEPTIN C,CC[C@H](C)[C@H]1C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@H](C)CC)C(=O)O[C@H](C)[C@H](NC(=O)[C@@H](CCc2ccc(O)cc2)NC(=O)[C@@H](CO)OC)C(=O)N[C@@H](CC2C=CC(O)C=C2)C(=O)N[C@H]2CC[C@@H](OC)N1C2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9885,ML00003072,,,CC(C)[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCCCN=C(N)N)[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9886,ML00002869,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](O)COS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9887,ML00005055,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9888,ML00005025,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)CCCCCCCCCCCCC)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9889,ML00001443,CHEMBL2011684,,CC[C@@H](C)[C@H]1C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](O)Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N1C2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9890,ML00005135,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCCCC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9891,ML00009396,,,COC1(C[C@@H]2C(=O)N[C@@H](c3ccc(O)cc3)CC(=O)O[C@@H](C)C[C@@H](C)/C=C(\C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N2C)OC(=O)Nc2ccccc21,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9892,ML00010744,,,CCCCCC[C@H]1OC(=O)CNC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9893,ML00000669,CHEMBL1489059,,CO[C@@H]1COC(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)[C@H](C)NC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9894,ML00005978,,,CC[C@H](C)[C@H]1NC(=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCCCNC(=N)N)[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@H]([C@H](C)CC)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9895,ML00001259,CHEMBL508619,TASIPEPTIN B,CCCC(=O)N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9896,ML00010381,,,CC1=C[C@@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@@H](O)[C@@H](C)OCC/C(C)=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9897,ML00000781,CHEMBL1075639,,CC[C@H](C)[C@H]1C(=O)N(C)[C@@H](Cc2ccc(OC)c(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)[C@H](O)CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]2CC[C@@H](O)N1C2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9898,ML00003800,,,CCCCCC/C=C/CCC[C@H]1CC(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9899,ML00004421,,,CCCCCCCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](Cc2ccccc2)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9900,ML00010892,,,C=CC[C@@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@@H]([C@H](C)CC)N(C)C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9901,ML00000324,CHEMBL1436441,,CO[C@H]1COC(=O)[C@H](C)NC(=O)C/C=C\[C@@H](C)[C@@H](NS(=O)(=O)c2ccc(C)cc2)COC(=O)[C@H](OCc2ccccc2)/C=C\[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9902,ML00010063,,,CCC(C)C1NC(=O)C2CCCN2C(=O)C(CC(O)CCl)OC(=O)CCNC(=O)C(C)N(C)C(=O)C(C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9903,ML00005094,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCNC(=O)c2cc3ccc(N(CC)CC)cc3oc2=O)NC(=O)[C@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CCCC(C)C)C(C)C)[C@H](C)O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9904,ML00005670,,,CC[C@H](C)C[C@@H]1CC[C@@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)N(C)[C@H](Cc3ccccc3)C(=O)N3NCCC[C@@H]3C(=O)N[C@H](CO)C(=O)O[C@@H]2C(C)C)O[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9905,ML00000762,CHEMBL1078917,MICROPEPTIN 478-A,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](O)COS(C)(=O)=O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9906,ML00010881,,,CC[C@H](C)[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](C[C@H](O)CCl)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@@H]([C@H](C)CC)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9907,ML00010395,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\[C@@H](O)[C@H](C)OCC/C(C)=C/C(=O)OCC2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9908,ML00008691,,,O=C1CCCCCCCCCCCCCCCCCO1,standard_macrolactone,19.0,,,success,,0.0,[],ring_size_19/standard/numbered/ML00008691_numbered.png,2026-03-19 06:59:03.334130
9909,ML00003578,,,CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](C)N(C)C(=O)[C@@H](C(C)C)NC(=O)[C@H](C)N(C)C(=O)[C@@H](N(C)C(=O)C[C@H](C)C(Cl)Cl)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9910,ML00010233,,,CC[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9911,ML00007089,,,C/C1=C/CC[C@H](C)CCO[C@@H]2O[C@H](CO[C@@H]3OC[C@](O)(COC1=O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9912,ML00009434,,,CC[C@@H](C)[C@H]1NC(=O)[C@@H](NC(C)=O)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9913,ML00005603,,,CC(C)[C@H]1NC(=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCCCN=C(N)N)[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9914,ML00000282,CHEMBL1453872,,CO[C@H]1COC(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)[C@H](Cc2ccccc2)NC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9915,ML00007443,,,C[C@@H](O)[C@H]1C(=O)N2C3=C(S[C@@H]4CN[C@@H](C4)C(=O)Nc4cccc(c4)C(=O)OC/C=C\COC3=O)[C@H](C)[C@H]12,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9916,ML00010874,,,CC[C@H](C)[C@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]([C@H](C)CC)OC(=O)CCNC(=O)[C@@H](C)N(C)C(=O)[C@@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9917,ML00000907,CHEMBL452871,KAHALALIDE R,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)C(C(C)C)NC(=O)C(C(C)C)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)C(NC(=O)C(NC(=O)C(NC(=O)[C@@H](CCC(=O)O)NC(=O)CCCCCC(C)C)C(C)C)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)C(C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9918,ML00000807,CHEMBL1773901,COCOSAMIDE A,C=CCCC[C@@H]1OC(=O)CNC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)NC(=O)C1(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9919,ML00003687,,,CC[C@H](C)[C@@H](NC=O)C(=O)N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(C)C)C(=O)N2NCCC[C@H]2C(=O)N[C@H](CC(C)C)C(=O)N2NCCC[C@H]2C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9920,ML00003738,,,COC[C@H]1C(=O)NCC(=O)N2N=CCC[C@H]2C(=O)N(O)[C@H](C)C(=O)O[C@@H](C(C)C)[C@H](NC(=O)[C@](C)(O)[C@]2(O)CC[C@@H](CC(C)C)[C@H](C)O2)C(=O)N2N=CCC[C@@H]2C(=O)N1O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9921,ML00004786,,,CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2CC(=O)[C@H](CS[C@@H]3CN4CCC3CC4)CN2C(=O)[C@H](Cc2ccc(N(C)C)cc2)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9922,ML00005141,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)CCCC(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9923,ML00005697,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)OC)C(C)C)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9924,ML00001983,CHEMBL1165575,JASPAMIDE E,C/C1=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9925,ML00005613,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)N(C)C(=O)[C@H]([C@@H](C)O)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CCC(=O)N2)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9926,ML00006011,,,CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@H](C)OC(=O)[C@H](c2ccccc2)NC(=O)[C@H]2CC(=O)CCN2C(=O)[C@H](Cc2ccc(N(C)C)cc2)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9927,ML00002912,,,CC[C@H](C)[C@H]1NC(=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCCCN=C(N)N)[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9928,ML00005466,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9929,ML00007280,,,CC(=O)C(=O)N[C@@H]1C(=O)N2NCCC[C@@H]2C(=O)N(O)[C@@H](C)C(=O)NCC(=O)N2NCCC[C@H]2C(=O)N(O)[C@H](C)C(=O)O[C@H]1C(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9930,ML00005054,,,C/C=C1\NC(=O)[C@H](c2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9931,ML00005638,,,CC[C@H](C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H]1C(=O)N[C@H](CC(C)C)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9932,ML00005686,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(C)=O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9933,ML00005948,,,CC(C)C[C@H]1C(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C)[C@H](N(C)C(=O)c2ccccc2)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9934,ML00001946,CHEMBL325145,,CC1(C)COC(=O)CCCCC(=O)CCC(C)(C)[C@@H](CCc2ccccc2)OC(=O)[C@@H]2CCCCN2C(=O)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9935,ML00006522,,,CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCCNC)C(=O)N[C@H]2CC[C@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9936,ML00010129,,,CO[C@H]1C[C@H]2O[C@@H]1/C=C(/C)[C@@H](O)C/C=C\C=C(\C)C(=O)[C@@H](C)/C=C(/C)C(=O)O[C@H](/C=C/[C@H]1O[C@@H]1C)[C@@H]2C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9937,ML00001582,CHEMBL2304256,SCYPTOLIN A,CCCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]2CC[C@H](O)N(C2=O)[C@@H](C(C)O)C(=O)N[C@@H](Cc2ccc(O)c(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)O[C@H]1C)[C@@H](C)O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9938,ML00003405,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3CCCC[C@@H]3C(=O)N(O)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9939,ML00006225,,,CO[C@@H]1CC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)N[C@@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](O)Cc3ccc(O)cc3)C(=O)N[C@@H](CC(C)C)C(=O)N21,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9940,ML00010082,,,CC[C@H]1CC(=O)O[C@@H](C)C(=O)N(C)[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)c2nc(cs2)C(=O)N1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9941,ML00000860,CHEMBL3577227,,CC[C@H](C)[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(C)C)NC(=O)C[C@@H](CCCCCCC(C)C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9942,ML00001298,CHEMBL1076834,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2OC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](CO)OS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9943,ML00005637,,,CC[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H]1C(=O)N[C@H](CC(C)C)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](CC(C)C)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@@H](CO)C(=O)O[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9944,ML00005171,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)c2ccc(C(F)(F)F)cc2)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9945,ML00001148,CHEMBL585404,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)C)NC(=O)OCCC/C=C\c1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9946,ML00001299,CHEMBL1076832,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2OC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](O)COS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9947,ML00009617,,,CC(C)CCC1CCC(O)(C(C)(O)C(=O)NC2C(=O)N3NCCCC3C(=O)N(O)C(C)C(=O)NCC(=O)N3NCCCC3C(=O)NC(C)C(=O)OC2C(C)O)OC1CO,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9948,ML00000969,CHEMBL404063,MICROPEPTIN SD999,CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H]([C@@H](C)CC)C(=O)N(C)[C@@H](CC(=O)c2ccccc2N)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9949,ML00008835,,,C[C@H]1C[C@@H](C)/C=C\C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@@H](c2ccc(O)cc2)CC(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9950,ML00000961,CHEMBL2385895,,CO[C@@H]1CC[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)N[C@@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](O)Cc3ccc(O)cc3)C(=O)N[C@@H](CC(C)C)C(=O)N12,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9951,ML00004933,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(C)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9952,ML00006198,,,CC[C@@H](C)[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCCCCCCCCCN=C(N)N)[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9953,ML00010494,,,CC(/C=C/C(C)=C/[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C#CC(=O)O1)=C\CN1CCCC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9954,ML00010569,,,CC[C@H](C)[C@H]1NC(=O)[C@@H]2C[C@H](C)CN2C(=O)[C@@H]([C@H](C)CC)OC(=O)CCNC(=O)[C@@H](C)N(C)C(=O)[C@@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9955,ML00009671,,,C/C1=C/[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@@H](c2ccc(O)cc2)CC(=O)O[C@@H](C)C[C@@H](C)[C@H]1O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9956,ML00005996,,,CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2CC(=O)CCN2C(=O)[C@H](Cc2ccc(N(C)C)cc2)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9957,ML00000971,CHEMBL255705,CYANOPEPTOLIN 963A,CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9958,ML00000235,CHEMBL603170,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9959,ML00005099,,,C/C=C1\NC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9960,ML00000683,CHEMBL591548,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1(C)CCCCC1)NC(=O)OCCC/C=C/c1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9961,ML00000679,CHEMBL602119,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCCC/C=C/c1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9962,ML00004788,,,C=C1[C@H](Cc2ccc(N(C)C)cc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](CC)NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@H](C)OC(=O)[C@@H](c2ccccc2)NC(=O)C2CC(=O)[C@H](SC3CN4CCC3CC4)CN12,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9963,ML00001626,CHEMBL412954,MICROPEPTIN B,CCCCCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9964,ML00010104,,,CO[C@H]1C[C@H]2O[C@H]1/C=C(/C)[C@H](O)C/C=C\C=C(\C)C(=O)[C@@H](C)/C=C(/C)C(=O)O[C@H](/C=C/[C@@H](O)[C@H](C)O)[C@@H]2C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9965,ML00005893,,,C/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C=C\C(=O)N(C)[C@@H]1C(=O)N[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9966,ML00009233,,,CCC[C@H]1NC(=O)c2csc(n2)[C@H](C)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9967,ML00009750,,,C/C1=C\[C@H](C)C[C@H](C)OC(=O)/C=C(/c2ccc(O)c(O)c2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9968,ML00001971,CHEMBL3126409,,CC(/C=C/CCCN(C)C)=C\[C@@H]1Cc2nc(cs2)[C@@H](C)C[C@@H](NC(=O)OC(C)(C)C)CC(=O)O[C@@H](C)C/C(C)=C/C=C\C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9969,ML00010742,,,CCCCCC[C@H]1OC(=O)CNC(=O)[C@@H]([C@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9970,ML00006487,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CCCN2C=O)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9971,ML00001955,CHEMBL3961277,,CCCCCC[C@H](C)[C@@H]1CC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9972,ML00006779,,,C[C@@H]1NC(=O)CC/C=C/CCCOC(=O)CCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9973,ML00009839,,,CCCCC[C@@H]1OC(=O)[C@@H](C(C)C)N(C)C(=O)[C@H]2CCCN2C(=O)[C@H](C(C)C)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9974,ML00007091,,,C/C1=C/CC[C@H](C)CCO[C@@H]2O[C@H](O[C@@H]3OC[C@H](C(=O)OC1)[C@@H](O)[C@H]3O)[C@@H](O)[C@@H](O)[C@H]2O,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
9975,ML00003444,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(C)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9976,ML00010912,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCN2C(=O)[C@@H](C[C@@H](C)C(=O)O)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9977,ML00004869,,,CCCCCCCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9978,ML00006010,,,CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2CC(=O)CCN2C(=O)[C@H](Cc2ccc(N(C)C)cc2)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9979,ML00000268,CHEMBL556318,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)C)NC(=O)OCCC/C=C/c1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9980,ML00000127,CHEMBL1591189,,Cc1ccc(S(=O)(=O)N[C@@H]2COC(=O)[C@H](C)NC(=O)C/C=C\[C@@H](C)[C@@H](NS(=O)(=O)c3ccc(C)cc3)COC(=O)C/C=C\[C@H]2C)cc1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9981,ML00005075,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9982,ML00003443,,,CC[C@@H]1O[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@H]3C(=O)N(O)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N[C@H](C)C(=O)O[C@@H]2C(C)C)CC[C@H]1CCC(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9983,ML00005131,,,C/C=C1\NC(=O)[C@H](Cc2ccc(I)cc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9984,ML00009511,,,CCCCC[C@@H]1OC(=O)[C@@H](C(C)C)N(C)C(=O)[C@H]2CCCN2C(=O)[C@H]([C@H](C)CC)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9985,ML00005078,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCNC(=O)C(F)(F)F)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9986,ML00002911,,,CC[C@H](C)[C@H]1NC(=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCCCNC(=N)N)[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@H]([C@H](C)CC)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9987,ML00010895,,,CCC[C@H]1NC(=O)c2csc(n2)[C@H](C)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]([C@@H](C)CC)OC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9988,ML00005132,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9989,ML00009166,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](N)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9990,ML00004761,,,CC(C)[C@H]1C(=O)OC[C@@H](NC(=O)c2cnc3ccccc3n2)C(=O)N[C@@H](C)C(=O)N(C)[C@H]2C[S+]([O-])C[S+]([O-])C[C@@H](C(=O)N1C)N(C)C(=O)[C@H](C)NC(=O)[C@H](NC(=O)c1cnc3ccccc3n1)COC(=O)[C@H](C(C)C)N(C)C2=O,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
9991,ML00009385,,,CC1=C[C@H]2[C@H]([C@@H]3[C@@H](c4ccc(O)cc4)OC(=O)/C=C\C(C)=C/C[C@H](O)[C@H](C)[C@@H](O)/C=C\C=C/C=C\[C@@H]13)C(C)(C)C[C@]2(C)O,standard_macrolactone,19.0,,,success,,5.0,"[3, 12, 13, 14, 17]",ring_size_19/standard/numbered/ML00009385_numbered.png,2026-03-19 06:59:04.083224
9992,ML00000222,CHEMBL600077,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCC/C=C/c1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9993,ML00003416,,,C#CCCC[C@H]1OC(=O)[C@H]([C@H](C)CC)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)OC(=O)[C@@H]([C@H](C)CC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9994,ML00000299,CHEMBL554992,HANTUPEPTIN A,C#CCCC[C@@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)OC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@H](C(C)C)NC(=O)C1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9995,ML00005024,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](N)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9996,ML00002881,,,CC[C@H](C)[C@H]1NC(=O)[C@@H](NC(=O)C(C)C)[C@@H](C)OC(=O)[C@H](COC(=O)CNC(C)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](c2ccc(OC)cc2)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9997,ML00006523,,,CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCCNC)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9998,ML00009906,,,CC(C)[C@@H]1OC(=O)[C@@H](C)N(O)C(=O)[C@@H]2CCCNN2C(=O)CNC(=O)[C@H](C)N(O)C(=O)[C@H]2CCCNN2C(=O)[C@H]1NC(=O)[C@](C)(O)CCCc1ccccc1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9999,ML00010889,,,CCC(C)C1NC(=O)C2CCCN2C(=O)C(CC(C)C(=O)O)OC(=O)CCNC(=O)C(C)N(C)C(=O)C(C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10000,ML00010497,,,CC1(C)COC(=O)CCCCC(=O)C=CC(C)(C)[C@@H](CCc2ccccc2)OC(=O)[C@@H]2CCCCN2C(=O)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10001,ML00004952,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10002,ML00009759,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)c(Br)c2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10003,ML00002456,,,CCCCC[C@@H]1OC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10004,ML00003130,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](O)COS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10005,ML00000970,CHEMBL255437,MICROPEPTIN SD979,CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H]([C@@H](C)CC)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10006,ML00005166,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10007,ML00005120,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCNC(=O)CCOCCOCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10008,ML00009673,,,C=C1C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@@H](c2ccc(O)cc2)CC(=O)O[C@@H](C)C[C@@H](C)[C@@H]1O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10009,ML00003737,,,COCC1C(=O)NCC(=O)N2N=CCCC2C(=O)N(O)C(C)C(=O)OC(C(C)C)C(NC(=O)C(C)(O)C2(O)CCC(CC(C)C)C(C)O2)C(=O)N2N=CCCC2C(=O)N1O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10010,ML00001991,CHEMBL3126415,,COCCC/C=C/C(C)=C/[C@@H]1Cc2nc(cs2)[C@@H](C)C[C@@H](NC(=O)OC(C)(C)C)CC(=O)O[C@@H](C)C/C(C)=C/C#CC(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10011,ML00009668,,,C[C@H]1C[C@@H](C)/C=C(/CO)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@@H](c2ccc(O)cc2)CC(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10012,ML00009817,,,CCCCCCC(C)[C@@H]1CC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10013,ML00001533,CHEMBL403901,LARGAMIDE E,CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@H](CCCc2ccc(O)cc2)NC(=O)[C@H](O)CO)C(C)C)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H]([C@@H](C)O)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10014,ML00000861,CHEMBL1783474,TETRAHYDROVERAGUAMIDE A,CCCCC[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10015,ML00009482,,,COc1ccc([C@H]2CC(=O)O[C@@H](C)C[C@@H](C)/C=C(\C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc3c(Br)[nH]c4ccccc34)C(=O)N2)cc1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10016,ML00006009,,,CC[C@@H]1NC(=O)[C@H](NC(=O)c2ccccc2O)N(C)OC(=O)[C@@H](c2ccccc2)NC(=O)[C@@H]2CC(=O)CCN2C(=O)[C@H](Cc2ccc(N(C)C)cc2)N(C)C(=O)[C@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10017,ML00003692,,,COC[C@H]1C(=O)NCC(=O)N2NCCC[C@H]2C(=O)N(O)[C@H](C)C(=O)O[C@@H](C(C)C)[C@H](NC(=O)[C@](C)(O)[C@]2(O)CC[C@@H](CC(C)C)[C@H](C)O2)C(=O)N2NCCC[C@@H]2C(=O)N1O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10018,ML00000836,CHEMBL1720380,,CC1=CC(C)CC(C)OC(=O)CC(c2ccc(O)cc2)NC(=O)C(Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)C(C)NC(=O)C(C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10019,ML00006130,,,CCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](Cc2ccccc2)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10020,ML00002051,CHEMBL212328,,CN1C(=O)CCCCCCCCC(=O)OCC2C(CC3CCC2N3C)c2ccc1cc2,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10021,ML00003673,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N[C@H](CCCN)C(=O)N(O)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10022,ML00009726,,,C/C1=C\[C@H](C)CC(C)OC(=O)CC(c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10023,ML00006015,,,CCC1NC(=O)C(NC(=O)c2ncccc2O)C(C)OC(=O)C(c2ccccc2)NC(=O)C2CC(=O)CCN2C(=O)C(Cc2ccc(N(C)C)cc2)N(C)C(=O)C2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10024,ML00003103,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCCCN=C(N)N)[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10025,ML00000942,CHEMBL503397,CYANOPEPTOLIN 954,CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](Cc2ccccc2)C(=O)N(C)[C@@H](Cc2ccc(O)c(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)O[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10026,ML00010154,,,CCC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](C[C@@H](O)CO)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10027,ML00001345,CHEMBL4100786,,CCCCCCC[C@@H]1CC(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10028,ML00001405,CHEMBL3577229,,CCCCCCCCCCC[C@@H]1CC(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10029,ML00009679,,,COc1ccc([C@H]2CC(=O)O[C@@H](C)C[C@@H](C)/C=C(\C)CCC(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc3c(Br)[nH]c4ccccc34)C(=O)N2)cc1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10030,ML00003792,,,COC[C@H]1C(=O)NCC(=O)N2N=CCC[C@H]2C(=O)N(O)[C@H](C)C(=O)O[C@@H](C(C)C)[C@H](NC(=O)[C@](C)(O)[C@]2(O)CC[C@@H](CC(C)C)[C@H](C)O2)C(=O)N2NCCC[C@@H]2C(=O)N1O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10031,ML00003131,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](O)COS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10032,ML00000036,CHEMBL3126408,,CC(/C=C/C(C)=C/[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C=C\C(=O)O1)=C\CN(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10033,ML00010911,,,C=CCC1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2C(C)CCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10034,ML00005146,,,C/C=C1\NC(=O)[C@H](Cc2ccc(F)c(F)c2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10035,ML00009968,,,CCC(C)C1NC(=O)C2CCCN2C(=O)C(CC2CO2)OC(=O)CCNC(=O)C(C)N(C)C(=O)C(C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10036,ML00005097,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)[C@H]2CC[C@H]3[C@@H]4CC[C@@H]5C[C@H](O)CC[C@]5(C)[C@H]4CC[C@@]32C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10037,ML00005747,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)[O-])OC)C(C)C)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10038,ML00001427,CHEMBL1078518,ITRALAMIDE B,CC(CC(=O)N(C)[C@@H]1C(=O)N(C)[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N(C)[C@@H](C)C(=O)N(C)[C@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C)C(Cl)Cl,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10039,ML00003693,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@@H]3C(=O)N(O)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10040,ML00009371,,,CC1=C[C@H]2[C@H]([C@H]3[C@@H](c4ccc(O)cc4)OC(=O)/C=C\C(C)=C/C[C@H](O)[C@H](C)[C@H](O)/C=C\C=C/C=C\[C@@H]13)C(C)(C)C[C@]2(C)O,standard_macrolactone,19.0,,,success,,5.0,"[3, 12, 13, 14, 17]",ring_size_19/standard/numbered/ML00009371_numbered.png,2026-03-19 06:59:04.484564
10041,ML00001324,CHEMBL2041195,JASPAMIDE D,CC[C@H]1NC(=O)[C@@H](C)C/C(C)=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10042,ML00002972,,,CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)C(C)OC(=O)[C@H](c2ccccc2)NC(=O)C2CC(=O)CCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10043,ML00010572,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@@H](C)N(C)C(=O)[C@H]([C@H](C)CC)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10044,ML00010741,,,CCCCCC[C@H]1OC(=O)CNC(=O)[C@@H]([C@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10045,ML00010234,,,CC(C)C[C@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10046,ML00003689,,,CCCCCC[C@H]1CC[C@@](O)([C@@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@@H](COC)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)O[C@H]2C)OC1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10047,ML00004465,,,CCCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10048,ML00006612,,,CO[C@@H]1COC(=O)[C@H]2CCCN2C(=O)C/C=C\[C@@H](C)[C@H](OC)COC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10049,ML00001495,CHEMBL256745,MICROPEPTIN 88Y,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(C)=O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10050,ML00007349,,,COC/C=C/C=C/C(C)=C/[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C#CC(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10051,ML00006074,,,CC[C@H](C)[C@H]1C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](O)Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]2CC[C@@H](O)N1C2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10052,ML00010317,,,C=CC[C@@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10053,ML00009561,,,CCCCCCCCC[C@H]1CC(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10054,ML00005064,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](C(C)C)N(CCCCCC)CCCCCC)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10055,ML00003605,,,C/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OCCc3ccc(cc3)Oc3cc(ccc3O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)CCOC(=O)C[C@H]21,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10056,ML00007236,,,CC(/C=C/C=C/CO)=C\[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C#CC(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10057,ML00004284,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](O)COS(=O)(=O)O)[C@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10058,ML00005138,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10059,ML00004346,,,CC[C@H](C)[C@H]1C(=O)N(C)[C@@H](Cc2ccc(OC)c(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)[C@H](O)COS(=O)(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]2CC[C@@H](O)N1C2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10060,ML00006403,,,CC(C)[C@H]1NC(=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCCCN=C(N)N)[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10061,ML00000745,CHEMBL600076,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCC/C=C/c1ccccc1CN(C)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10062,ML00004964,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10063,ML00005066,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCC[N+](C)(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10064,ML00009649,,,C/C1=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2ncnc3ccccc23)N(C)C(=O)C(C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10065,ML00003471,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](O)COS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10066,ML00002389,,,CC[C@H](C)[C@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](NC(=O)[C@@H](NC=O)[C@H](C)CC)[C@@H](C)OC(=O)[C@H](C)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@@H]2C[C@H](O)CNN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10067,ML00011036,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCNC(=O)CCOCCOCCNC(=O)OCC2c3ccccc3-c3ccccc32)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10068,ML00009769,,,C[C@H]1C[C@@H](C)/C=C(/C=O)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@@H](c2ccc(O)cc2)CC(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10069,ML00001236,CHEMBL1078912,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)O)OS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10070,ML00000796,CHEMBL334163,,CC[C@]1(OC(C)=O)[C@H](O)C[C@H](O)[C@@]2(C)C(=O)[C@H](OC(C)=O)C3=C(C)[C@@H]4CC(O)([C@@H](OC(=O)c5cccc(c5)CCCOC(=O)N[C@@H](CC(C)C)[C@@H](O)C(=O)O4)[C@@H]21)C3(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10071,ML00008995,,,CC(C)CCCCC(C)(C)CCCC1CC(=O)NCC(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10072,ML00010871,,,CC[C@H](C)[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10073,ML00001095,CHEMBL1474497,,CO[C@@H]1COC(=O)[C@H]2CCCN2C(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10074,ML00005160,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10075,ML00006741,,,O=C1/C=C\c2ccc(c(O)c2)O[C@@H]2O[C@H](COC(=O)/C=C\c3cc(O)c(O)cc3C1)[C@@H](O)[C@H](O)[C@H]2O,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10076,ML00010157,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10077,ML00007437,,,C[C@@H](O)[C@H]1C(=O)N2C3=C(S[C@@H]4CN[C@@H](C4)C(=O)Nc4cccc(c4)C(=O)OCCCCOC3=O)[C@H](C)[C@H]12,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10078,ML00005725,,,CC(C)[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10079,ML00001976,CHEMBL3577225,,CCCCCCC[C@@H]1CC(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10080,ML00004241,,,COc1ccc(C[C@H]2NC(=O)[C@@H](NC(=O)[C@@H](NC=O)C(C)C)[C@@H](C)OC(=O)[C@H](C)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@@H]3C[C@H](O)CNN3C(=O)[C@@H](C(C)C)NC2=O)cc1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10081,ML00005564,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(OCc3ccccc3)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10082,ML00000782,CHEMBL1783472,VERAGUAMIDE F,C#CCCC[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10083,ML00010829,,,CCC(C)C1NC(=O)C2C(C)CCN2C(=O)C(CC(O)CO)OC(=O)CCNC(=O)C(C)N(C)C(=O)C(C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10084,ML00001522,CHEMBL396553,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN(CCCCCC)CCCCCC)NC(=O)[C@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CCCC(C)C)C(C)C)[C@H](C)O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10085,ML00001404,CHEMBL3577231,,CC[C@H](C)[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(C)C)NC(=O)C[C@@H](CCCCCCCCC(C)C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10086,ML00009462,,,CCCCCCCCCC[C@H]1OC(=O)CNC(=O)[C@H]([C@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10087,ML00009965,,,C=CC[C@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10088,ML00001994,CHEMBL2407689,,CC(C)C[C@@H]1OC(=O)CCNC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10089,ML00009717,,,C/C1=C/[C@H](C)C[C@@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10090,ML00000761,CHEMBL1078915,,CC[C@H](C)[C@H]1C(=O)N(C)[C@@H](Cc2ccc(OC)c(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)[C@H](O)CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]2CC[C@@H](OC)N1C2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10091,ML00004953,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)CCCC(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10092,ML00005164,,,C/C=C1\NC(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10093,ML00010894,,,C=CC[C@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2[C@@H](C)CCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10094,ML00006014,,,CCC1NC(=O)C(NC(=O)c2ncccc2O)C(C)OC(=O)C(c2ccccc2)NC(=O)C2CC(=O)CCN2C(=O)C(Cc2ccc(N(C)C)cc2)N(C)C(=O)C2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10095,ML00004627,,,CC[C@H](C)[C@H](NC(=O)[C@H](O)Cc1ccc(O)cc1)C(=O)N[C@@H](CCO)C(=O)N[C@@H]1C(=O)N[C@@H](CCO)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](Cc2ccccc2)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10096,ML00004974,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10097,ML00010549,,,CC(C)[C@@H]1OC(=O)[C@@H](C)[C@H](C)NC(=O)c2csc(n2)[C@H](C)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10098,ML00001474,CHEMBL439421,PLANKTOPEPTIN BL1061,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)N(C)C(=O)[C@H]([C@@H](C)O)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](O)CO)C(C)C)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10099,ML00005191,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10100,ML00005065,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCC[N+](C)(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10101,ML00010705,,,CC[C@H](C)[C@H]1C(=O)N(C)[C@@H](C)C(=O)NCCC(=O)O[C@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@](C)([C@H](C)CC)C(=O)N1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10102,ML00001471,CHEMBL2338547,LYNGBYASTATIN 9,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CCC)C(C)C)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10103,ML00005107,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CCC2CCCCC2)NC(=O)[C@@H](CCC2CCCCC2)NC(=O)[C@H](NC(=O)[C@@H](CCC2CCCCC2)NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10104,ML00003553,,,CC[C@@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@H]2C[C@@H](O)CCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10105,ML00004589,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10106,ML00000283,CHEMBL380056,,CN1CCCCCCCCCC(=O)OCC2C(CC3CCC2N3C)c2ccc1cc2,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10107,ML00001905,CHEMBL3126412,,CC(/C=C/C(C)=C/[C@@H]1Cc2nc(cs2)[C@@H](C)C[C@@H](NC(=O)C(F)(F)F)CC(=O)O[C@@H](C)C/C(C)=C/C=C\C(=O)O1)=C\CN(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10108,ML00009672,,,C=C1C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@@H](c2ccc(O)cc2)CC(=O)O[C@@H](C)C[C@@H](C)C1O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10109,ML00004348,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](O)COS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10110,ML00005089,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@@H]2CC[C@H](c3ccccc3)N2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10111,ML00010571,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H]([C@@H](C)CC)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10112,ML00000238,CHEMBL211372,,CN1C2CCC1C1COC(=O)CCCCCCCCC(=O)Nc3ccc(cc3)C1C2,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10113,ML00005122,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCNC(=O)/C=C/CCC)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10114,ML00005123,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10115,ML00004242,,,COc1ccc(C[C@H]2NC(=O)[C@H](NC(=O)[C@@H](NC=O)C(C)C)[C@@H](C)OC(=O)[C@H](C)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@@H]3CCCNN3C(=O)[C@@H](C(C)C)NC2=O)cc1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10116,ML00004975,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)CCCC(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10117,ML00000325,CHEMBL388681,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCNCc2cccs2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CCCC(C)C)C(C)C)[C@H](C)O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10118,ML00008869,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@H](CC(=O)c2ccccc2N)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10119,ML00001658,CHEMBL256742,MICROPEPTIN E1964,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10120,ML00006072,,,CCCCCC(=O)N[C@H](C(=O)N[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](Cc2ccccc2)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@@H]1C)[C@@H](C)O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10121,ML00000624,CHEMBL1571027,,CO[C@H]1COC(=O)[C@H](C)NC(=O)C/C=C\[C@@H](C)[C@@H](NS(=O)(=O)c2ccc(C)cc2)COC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10122,ML00001940,CHEMBL324539,,CC1(C)COC(=O)CCCCC(=O)/C=C/C(C)(C)[C@@H](CCc2ccccc2)OC(=O)[C@@H]2CCCCN2C(=O)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10123,ML00003307,,,CC[C@@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(C)=O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10124,ML00003924,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(C(C)=O)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10125,ML00009755,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](c2c(O)c3ccccc3[nH]c2=O)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10126,ML00006578,,,C/C=C(\C)C(=O)[C@H](C)/C=C(\C)[C@@H]1O[C@](O)([C@@](O)(CC)C(=O)N[C@H]2C(=O)N3NCCC[C@H]3C(=O)N(O)[C@@H](C)C(=O)N(C)[C@H](C)C(=O)N3NCCC[C@H]3C(=O)N[C@@H]([C@H](C)O)C(=O)O[C@@H]2C(C)C)CC[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10127,ML00009181,,,CC(/C=C/CCCO)=C\[C@@H]1Cc2nc(cs2)[C@@H](C)C[C@@H](NC(=O)OC(C)(C)C)CC(=O)O[C@@H](C)C/C(C)=C/C=C\C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10128,ML00009899,,,CC(C)C[C@@H]1OC(=O)CCNC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10129,ML00001542,CHEMBL403305,MICROPEPTIN 88C,CCCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10130,ML00003747,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2OC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10131,ML00005900,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)O)OC)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10132,ML00000278,CHEMBL1527579,,CO[C@@H]1COC(=O)[C@@H](OCc2ccccc2)/C=C\[C@H](C)[C@@H](OC)COC(=O)[C@H]2CCCN2C(=O)C/C=C\[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10133,ML00001428,CHEMBL4074673,,CCCCCCC[C@@H]1CC(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10134,ML00004670,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10135,ML00003442,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@@H](C)C(=O)N[C@H](C)C(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10136,ML00007128,,,COc1cc(O)c2c(c1)/C=C/CC(=O)OC/C=C\COC(=O)CCC[C@H](C)OC2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10137,ML00010782,,,CCCC[C@H](C)[C@H]1CC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10138,ML00002103,CHEMBL2407688,ROSEOCARDIN,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2[C@@H](C)CCN2C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10139,ML00001300,CHEMBL1076835,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2OC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)O)OS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10140,ML00006013,,,CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@H](C)OC(=O)[C@@H](c2ccccc2)NC(=O)[C@H]2CC(=O)CCN2C(=O)[C@@H](Cc2ccc(N(C)C)cc2)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10141,ML00001980,CHEMBL2041198,PIPESTELIDE A,C/C1=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)c(Br)c2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10142,ML00004129,,,C#CCCC[C@@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10143,ML00009286,,,C=C/C=C(\C)[C@@H](O)CC[C@H](C)/C=C/[C@H]1CC[C@H](C)C(=O)CC(=O)N[C@H](C)CCC(=O)[C@H](C)[C@@H](O)[C@H](C)/C=C(/C)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10144,ML00007374,,,C=CC[C@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10145,ML00008836,,,C[C@H]1C[C@@H](C)/C=C/C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@@H](c2ccc(O)cc2)CC(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10146,ML00007098,,,CO[C@H]1COC(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)[C@@H](C)NC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10147,ML00006494,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)O)OC)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10148,ML00005892,,,C/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(=O)N(C)[C@@H]1C(=O)N[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10149,ML00010890,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCCN2C(=O)[C@@H](C[C@@H]2CO2)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10150,ML00000714,CHEMBL603168,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCCC/C=C/c1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10151,ML00010495,,,CC(/C=C/C(C)=C/[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C#CC(=O)O1)=C\CN1CCOCC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10152,ML00001545,CHEMBL410586,MICROPEPTIN 88D,CCCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CC2C=CC(O)CC2)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10153,ML00009806,,,C#CCCC[C@@H]1OC(=O)[C@@H](C(C)C)N(C)C(=O)[C@H]2CCCN2C(=O)[C@H](C(C)C)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10154,ML00001725,CHEMBL2115526,,CC1(C)COC(=O)CCCCCCCCCOC(=O)[C@@H]2CCCCN2C(=O)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10155,ML00000275,CHEMBL3126418,,CC(/C=C/C(C)=C/[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C=C\C(=O)O1)=C\CN1CCCC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10156,ML00005746,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)[O-])OC)C(C)C)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10157,ML00000758,CHEMBL1078911,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)c(Cl)c2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](O)COS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10158,ML00010867,,,CCC(C)C1NC(=O)C2CCCN2C(=O)C(CC(C)(C)O)OC(=O)CCNC(=O)C(C)N(C)C(=O)C(C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10159,ML00009819,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N[C@H](C)C(=O)OC2C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10160,ML00005797,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(CC(=O)OC(C)(C)C)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10161,ML00007099,,,CO[C@@H]1COC(=O)[C@H](C)NC(=O)C/C=C\[C@@H](C)[C@H](OC)COC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10162,ML00005566,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(OCc3ccccc3)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10163,ML00003732,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10164,ML00006404,,,CC(C)[C@H]1NC(=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCCCN=C(N)N)[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10165,ML00002969,,,CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@H](C)OC(=O)[C@@H](c2ccccc2)NC(=O)[C@H]2CC(=O)CCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10166,ML00000345,CHEMBL403894,,CC(C)C[C@H]1C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](O)COS(=O)(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]2CC[C@@H](O)N1C2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10167,ML00009433,,,CCC[C@H]1NC(=O)[C@@H](NC(C)=O)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(OC)cc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10168,ML00005152,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10169,ML00005059,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCNC(=O)C(F)(F)F)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)OC(=O)C(F)(F)F)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10170,ML00002983,,,CC[C@@H]1NC(=O)[C@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@H](c2ccccc2)NC(=O)[C@H]2CC(=O)CCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10171,ML00000623,CHEMBL1595856,,CO[C@@H]1/C=C\CC(=O)N[C@@H](C)C(=O)OC[C@H](NS(=O)(=O)c2ccc(C)cc2)[C@H](C)/C=C\CC(=O)OC[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10172,ML00010820,,,C[C@@H]1NC(=O)CC/C=C/CCCOC(=O)C[C@H](c2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10173,ML00005070,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10174,ML00005190,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10175,ML00010830,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](C[C@H](C)CO)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10176,ML00009884,,,C/C1=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](C[C@]2(O)C(=O)Nc3ccccc32)N(C)C(=O)C(C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10177,ML00008838,,,C/C1=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)CC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10178,ML00002382,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCCN(C)C)NC(=O)[C@@H](NC(=O)[C@H](O)COS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10179,ML00010162,,,CC(C)C[C@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10180,ML00009913,,,CC[C@@H](C)[C@H]1NC(=O)[C@@H](NC(C)=O)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10181,ML00005715,,,C/C=C1/NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)O)OC)C(C)C)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10182,ML00010866,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)C(CC(O)CCl)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H]([C@@H](C)CC)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10183,ML00009757,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3cc(Br)ccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10184,ML00010839,,,CC[C@H](C)[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](C[C@H](C)CO)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10185,ML00001556,CHEMBL401605,MICROPEPTIN 88A,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CC2C=CC(O)CC2)NC(=O)[C@@H](NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10186,ML00009347,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2ccc(O)c(I)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10187,ML00001531,CHEMBL401953,LARGAMIDE D,CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCc2ccc(O)cc2)NC(=O)[C@H](O)CO)C(C)C)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)c(Br)c2)N(C)C(=O)[C@H]([C@@H](C)O)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10188,ML00007086,,,CO[C@@H]1COC(=O)[C@@H](C)NC(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)CCC[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10189,ML00007322,,,COCCC/C=C/C(C)=C/[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C=C\C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10190,ML00009231,,,C=C1CC/C=C(/C)[C@@H](O)CC(=O)[C@H](C)CC(=O)C[C@H]2CC[C@@H](O2)[C@H](/C=C/C=C(\C)[C@@H](O)C(=C)CCCC)OC(=O)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10191,ML00001270,CHEMBL552944,MICROPEPTIN 90,CC(C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](O)COS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10192,ML00002970,,,CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2CC(=O)CCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10193,ML00007117,,,COc1cc(O)c2c(c1)/C=C/CC(=O)OCCCCOC(=O)CCC[C@H](C)OC2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10194,ML00001132,CHEMBL509769,,CCC[C@H](NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)C(=O)NC1CC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10195,ML00005136,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10196,ML00005134,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)C(C)C)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10197,ML00001370,CHEMBL552496,ARENAMIDE A,CCCCCC[C@H](C)[C@@H]1CC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10198,ML00000766,CHEMBL1076831,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2OC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](O)CO)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10199,ML00001530,CHEMBL553157,OSCILLAPEPTIN,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](CCc2ccc(O)cc2)NC(=O)[C@@H](COS(=O)(=O)O)OC)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10200,ML00005113,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCNC(=O)CCC2CCCCC2)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10201,ML00010602,,,Cc1oc(=O)oc1COC(=O)N1C[C@@H]2C[C@H]1C(=O)Nc1cccc(c1)C(=O)OC/C=C/COC(=O)C1=C(S2)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10202,ML00002558,,,CC(C)[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCCCN=C(N)N)[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10203,ML00009843,,,CCC(C)C1NC(=O)C2CCCN2C(=O)C(CC(C)(C)OC2OC(CO)C(O)C(O)C2O)OC(=O)CCNC(=O)C(C)N(C)C(=O)C(C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10204,ML00009288,,,CCCC[C@H](C)[C@@H]1CC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10205,ML00000204,CHEMBL603171,,CC[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCC/C=C/c1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10206,ML00009670,,,C[C@H]1CC2(C)OC2[C@H](C)C[C@@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10207,ML00000598,CHEMBL117192,,CC(C)=C[C@@H]1NC(=O)OC/C=C/c2cccc(c2)C(=O)O[C@H]2C=CC(=O)N3C[C@H](C[C@H]23)OC(=O)[C@@H]1O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10208,ML00005170,,,CC(C)C[C@H]1NC(=O)[C@H](CCC(N)=O)N(C)C(=O)[C@@H](N[C@H](CS(=O)(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(=O)N[C@@H](C(=O)[C@@H]2CCCN2C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](C)C=O)C(C)(C)C)C(C)(C)C)[C@@H](C)OC(=O)CN(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(N)=O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10209,ML00003440,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(OC)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10210,ML00004135,,,CC(C)C[C@@H]1OC(=O)CCNC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2[C@@H](C)CCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10211,ML00009047,,,CCC[C@H]1NC(=O)c2csc(n2)[C@H](C)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H]([C@@H](C)CC)OC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10212,ML00006473,,,CC[C@@H](C)[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCCCCCCCN=C(N)N)[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10213,ML00007367,,,CC[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10214,ML00008705,,,O=C1CCCCCCC/C=C\CCCCCCCCO1,standard_macrolactone,19.0,,,success,,0.0,[],ring_size_19/standard/numbered/ML00008705_numbered.png,2026-03-19 06:59:05.923418
10215,ML00003504,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(C)(C)O[C@@H]2O[C@H](COC(=O)CC(=O)O)[C@@H](O)[C@H](O)[C@H]2O)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10216,ML00003923,,,CCC[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@@H](C)C(=O)N3NCCC[C@@H]3C(=O)N3NC[C@@H](O)C[C@H]3C(=O)N[C@@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1CC,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10217,ML00005129,,,C/C=C1\NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10218,ML00001529,CHEMBL404109,OSCILLAPEPTIN A,CC[C@H](C)[C@H]1C(=O)N(C)[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@@H]([C@H](C)CC)C(=O)O[C@H](C)[C@H](NC(=O)[C@H](CCc2ccc(O)cc2)NC(=O)[C@@H](COS(=O)(=O)O)OC)C(=O)N[C@@H](CCc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N1C2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10219,ML00009480,,,CC[C@H]1NC(=O)[C@@H](C)C/C(C)=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10220,ML00010089,,,CC(/C=C/C(C)=C/[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C#CC(=O)O1)=C\CN(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10221,ML00006202,,,CC(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](Cc2ccccc2)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C)[C@@H](C)O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10222,ML00005665,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)CCCC(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10223,ML00001520,CHEMBL525411,KAHALALIDE S,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)C(C(C)C)NC(=O)C(C(C)C)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)C(NC(=O)C(NC(=O)C(NC(=O)[C@@H](CCC(=O)O)NC(=O)CCCC(O)CC(C)C)C(C)C)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)C(C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10224,ML00001519,CHEMBL3969725,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10225,ML00008833,,,COc1ccc([C@H]2CC(=O)O[C@@H](C)C[C@@H](C)/C=C(\C)CCC(=O)NCC(=O)N(C)[C@H](Cc3c(Br)[nH]c4ccccc34)C(=O)N2)cc1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10226,ML00010555,,,CCC(C)C1NC(=O)C2CCCN2C(=O)C(CC(C)(C)O)OC(=O)CCNC(=O)C(C)N(C)C(=O)C(C(C)CC)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10227,ML00009025,,,CC(C)C[C@@H]1OC(=O)CCNC(=O)[C@@H](C(C)C)N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10228,ML00004963,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCOC(C)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10229,ML00005184,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10230,ML00004764,,,CC(C)[C@H]1C(=O)OC[C@@H](NC(=O)c2cnc3ccccc3n2)C(=O)N[C@@H](C)C(=O)N(C)[C@H]2CSC[S+]([O-])C[C@@H](C(=O)N1C)N(C)C(=O)[C@H](C)NC(=O)[C@H](NC(=O)c1cnc3ccccc3n1)COC(=O)[C@H](C(C)C)N(C)C2=O,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10231,ML00002002,CHEMBL225054,EMERICELLAMIDE B,CCCCCC[C@H](C)C[C@H](C)[C@H]1OC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10232,ML00001398,CHEMBL1078913,,CC[C@H](C)[C@H]1C(=O)N(C)[C@@H](Cc2ccc(O)c(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)[C@@H](COS(=O)(=O)O)OS(=O)(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]2CC[C@@H](O)N1C2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10233,ML00009886,,,COc1ccc([C@H]2CC(=O)O[C@@H](C)C[C@@H](C)/C=C(\C)CCC(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc3c[nH]c4ccccc34)C(=O)N2)cc1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10234,ML00007331,,,CC(C)[C@@H]1NC(=O)CNC(=O)[C@H]2CSC(=N2)[C@H](C(C)(C)O)OC(=O)C(C)(C)[C@H](CCCC(C)(Cl)Cl)OC(=O)c2csc1n2,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10235,ML00001491,CHEMBL254783,OSCILLAPEPTIN F,CC[C@H](C)[C@H]1C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@H](C)CC)C(=O)O[C@H](C)[C@H](NC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](COS(=O)(=O)O)OC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]2CC[C@@H](O)N1C2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10236,ML00010746,,,CCCCCCC1OC(=O)CNC(=O)C(C(C)O)NC(=O)C(CO)NC(=O)C(C(C)CC)NC(=O)C(CC(C)C)N(C)C(=O)C1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10237,ML00002416,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)N(C)C(=O)[C@H]([C@H](C)O)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H]2CCC(=O)N2)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10238,ML00007341,,,COCCC/C=C/C(C)=C/[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C#CC(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10239,ML00003694,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10240,ML00003872,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N[C@H](CCCNC(C)=O)C(=O)N(O)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10241,ML00005108,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCNC(=O)C[C@](OC)(c2ccccc2)C(F)(F)F)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10242,ML00001392,CHEMBL3356719,,C=CCCCS(=O)(=O)NC(=O)[C@H](CCC)NC(=O)[C@H]1NC(=O)[C@H](C(C)(C)C)NC(=O)OCC/C=C/c2cc(nc(-c3ccccc3)n2)Oc2ccc1cc2,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10243,ML00001984,CHEMBL2041197,JASPAMIDE L,C[C@H]1C[C@@H](C)/C=C(\CO)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@@H](c2ccc(O)cc2)CC(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10244,ML00002455,,,CCCCC[C@@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)OC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10245,ML00005155,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCN(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10246,ML00003308,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(C)=O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10247,ML00005130,,,C/C=C1\NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10248,ML00010083,,,CC1=CC2OC3CC4OC(=O)/C=C/C=C/C(C(C)O)OCCC5(C)OC5C(=O)OCCC2(CC1)C4(C)C31CO1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10249,ML00001433,CHEMBL3577230,,CCCCCCCCCC[C@@H]1CC(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10250,ML00009024,,,CC(C)CC1OC(=O)C2CCCN2C(=O)CCNC(=O)C(Cc2ccccc2)NC(=O)C(C(C)C)N(C)C(=O)C(C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10251,ML00005111,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCCCCCCCCCCCCC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10252,ML00009912,,,NC(N)=NCCC[C@@H]1NC(=O)CNC(=O)[C@H](NC(=O)C[C@H](O)[C@H](N)CCCCNC(=O)c2cccc(O)c2O)COC(=O)[C@H]([C@H](O)C(=O)O)NC(=O)CNC(=O)[C@H]([C@H](O)C(=O)O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10253,ML00010888,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](C[C@@H](C)C(=O)O)OC(=O)CCNC(=O)[C@@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10254,ML00010318,,,C=CC[C@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10255,ML00002867,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2OC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](O)CO)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10256,ML00009031,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@H]2COC(=O)[C@@H](C)NC(=O)[C@@H]3CCCNN3C(=O)CNC(=O)[C@H](C)N(O)C(=O)[C@H]3CCCNN3C2=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10257,ML00010380,,,CC1=C[C@@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@@H](O)[C@H](C)OCC/C(C)=C\C(=O)OC[C@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10258,ML00009122,,,CCCCCCCCC[C@H]1CC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10259,ML00010394,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\[C@@H](O)[C@@H](C)OCC/C(C)=C/C(=O)OCC2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10260,ML00008834,,,C/C1=C/CC[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10261,ML00010119,,,C/C=C(C)/C=C(\C)C[C@H](C)[C@@H]1OC(=O)/C(C)=C\c2csc(n2)[C@@H](CO)[C@@H](O)C[C@H](O)/C=C\C=C/C[C@H](O)[C@H]1O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10262,ML00009287,,,CCCCC(C)[C@@H]1CC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10263,ML00005085,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10264,ML00010868,,,CC(C)C[C@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@](C)(C(C)C)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10265,ML00005742,,,CCCCCC(=O)NCC(=O)N[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](Cc2ccccc2)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10266,ML00003587,,,CCC(C)C1NC(=O)C2CCCN2C(=O)C(NC(C)=O)C(C)OC(=O)C(Cc2ccc(OC)cc2)N(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10267,ML00009715,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10268,ML00005158,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10269,ML00005688,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CCC)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10270,ML00001296,CHEMBL1078910,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)c(Cl)c2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)O)OS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10271,ML00003065,,,C=C(C/C(C)=C/[C@H](O)C[C@@H](C)C[C@@H]1CC/C=C\CCC[C@@H](O)/C=C\CC[C@H](O)[C@@H](O)/C=C\C(=O)O1)C[C@H](O)[C@H](O)C[C@H]1O[C@@H](C[C@H](O)CCO)[C@H](OS(=O)(=O)O)[C@H](O)[C@@H]1O,standard_macrolactone,19.0,,,success,,4.0,"[3, 11, 16, 17]",ring_size_19/standard/numbered/ML00003065_numbered.png,2026-03-19 06:59:06.455050
10272,ML00009966,,,C=CC[C@@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10273,ML00007324,,,CO[C@@H]1COC(=O)[C@@H](OCc2ccccc2)/C=C\[C@H](C)[C@@H](OC)COC(=O)[C@H](C)NC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10274,ML00005069,,,CC[C@@H](C)[C@@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]1CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(=O)N[C@H]1C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N/C(=C\c2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10275,ML00003071,,,CC(C)[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCCCNC(=N)N)[C@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H]([C@H](C)O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10276,ML00009461,,,CCCCCCCCCC[C@H]1OC(=O)CNC(=O)[C@@H]([C@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10277,ML00004425,,,CCCCCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](Cc2ccccc2)C(=O)N(C)[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10278,ML00009121,,,CCCCCCCCCC1CC(=O)NCC(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10279,ML00005125,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCCCCC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10280,ML00010156,,,CC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](C[C@H](C)CO)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10281,ML00005053,,,C=C1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10282,ML00003445,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(C)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10283,ML00008837,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)CC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10284,ML00008842,,,C/C1=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccccc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)CC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10285,ML00003731,,,CC[C@H](C)C[C@H]1CC[C@H]([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10286,ML00005074,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)/C=C/c2ccc(C(F)(F)F)cc2)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10287,ML00005083,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN)NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10288,ML00002913,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCCCN=C(N)N)[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10289,ML00010740,,,CCCCCC[C@H]1OC(=O)CNC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10290,ML00010979,,,C/C1=C/C=C\C(=O)O[C@H](/C=C(C)/C=C/C(C)=C/CN(C)C)Cc2nc(cs2)[C@@H](C)C[C@@H](N)CC(=O)O[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10291,ML00005407,,,CC(C)[C@H](NC(=O)[C@@H](C)NC(=O)[C@H](CCCc1ccc(O)cc1)NC(=O)[C@H](O)CO)C(=O)N[C@@H]1C(=O)N[C@@H](CCc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H]([C@@H](C)O)C(=O)N(C)[C@@H](Cc2ccc(O)c(Br)c2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10292,ML00004962,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)/C=C/C=C/C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10293,ML00005717,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)[O-])OC)C(C)C)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10294,ML00009026,,,CC(C)C[C@@H]1OC(=O)CCNC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10295,ML00010893,,,C=CC[C@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CCCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10296,ML00010550,,,CC1/C=C/CCCOC(=O)C[C@H](c2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10297,ML00010568,,,CC[C@H](C)[C@H]1NC(=O)[C@@H]2C[C@H](C)CN2C(=O)[C@H]([C@H](C)CC)OC(=O)CCNC(=O)[C@@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10298,ML00007561,,,C[C@@H](O)[C@H]1C(=O)N2C3=C(S[C@@H]4CN[C@@H](C4)C(=O)Nc4cccc(c4)C(=O)OCc4oc(=O)oc4COC3=O)[C@H](C)[C@H]12,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10299,ML00009888,,,C/C1=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10300,ML00009048,,,CCC[C@H]1NC(=O)c2csc(n2)[C@H](C)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H]([C@H](C)CC)OC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10301,ML00009856,,,CC(C)[C@@H]1NC(=O)[C@@H](C)[C@H](CCCC#CBr)OC(=O)[C@@H](C(C)C)N(C)C(=O)[C@H]2CCCN2C(=O)[C@H](C(C)C)OC(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10302,ML00006279,,,CC[C@H](C)C[C@H]1CC[C@](O)(C(C)(C)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@H](C)C(=O)N3NC[C@@H](C)C[C@@H]3C(=O)[C@@H]3CC[C@@](C)(O)[C@@H]3C(=O)N(O)[C@@H](C(C)C)C(=O)O[C@H]2C(C)C)O[C@]1(C)CC,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10303,ML00010745,,,CCCCCC[C@H]1OC(=O)CNC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](CO)NC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10304,ML00006496,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)[O-])OC)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10305,ML00000926,CHEMBL267201,MICROPEPTIN SD1002,CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H]([C@@H](C)CC)C(=O)N(C)[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10306,ML00003247,,,CCCCC[C@H]1CC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10307,ML00001549,CHEMBL412722,MICROPEPTIN 88F,CCCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10308,ML00005921,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H]([C@@H](C)O)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC=O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10309,ML00000597,CHEMBL1254425,,CC(C)=C[C@@H]1NC(=O)OC/C=C\c2cccc(c2)C(=O)O[C@H]2C=CC(=O)N3C[C@H](C[C@H]23)OC(=O)[C@@H]1O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10310,ML00006075,,,CC[C@H](C)[C@H]1C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](O)Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]2CC[C@@H](O)N1C2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10311,ML00001724,CHEMBL320252,,CC1(C)COC(=O)CCCCCCCCCOC(=O)C2CCCCN2C(=O)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10312,ML00009235,,,COCCC/C=C/C(C)=C/[C@@H]1Cc2nc(cs2)[C@@H](C)C[C@@H](NC(=O)OC(C)(C)C)CC(=O)O[C@@H](C)C/C(C)=C/C=C\C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10313,ML00009898,,,CC(C)C[C@@H]1OC(=O)CCNC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10314,ML00010120,,,C/C=C(C)/C=C(\C)C[C@H](C)[C@H]1OC(=O)/C(C)=C\c2csc(n2)[C@H](CO)[C@@H](O)C[C@H](O)/C=C\C=C/C[C@H](O)[C@H]1O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10315,ML00010869,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10316,ML00000972,CHEMBL2385896,,CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](O)Cc2ccc(O)cc2)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)N2C=CC[C@H](NC1=O)C2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10317,ML00006363,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)[O-])OC)C(C)C)[C@@H](C)OC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10318,ML00003168,,,CC[C@H](C)[C@H]1NC(=O)[C@@H](NC(=O)[C@H](C)[C@H](O)C(C)C)[C@@H](C)OC(=O)[C@H](CO)NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](c2ccc(OC)cc2)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10319,ML00006493,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@H](CC[S@](C)=O)NC(=O)CCCCC)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10320,ML00009650,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2ncnc3ccccc23)N(C)C(=O)[C@@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10321,ML00005181,,,CC[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10322,ML00006233,,,CCCCCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10323,ML00009973,,,CC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](C[C@@H](C)C(=O)O)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10324,ML00002478,,,C#CCCC[C@@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)OC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10325,ML00005092,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCCCCCCCCCCCCCCCCC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10326,ML00005102,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)[C@H]2CC[C@H]3[C@@H]4CC[C@@H]5C[C@H](OC(=O)C(F)(F)F)CC[C@]5(C)[C@H]4CC[C@@]32C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10327,ML00009882,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](C[C@]2(O)C(=O)Nc3ccccc32)N(C)C(=O)[C@@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10328,ML00002856,,,CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2CC(=O)CCN2C(=O)[C@H](Cc2ccc(NC)cc2)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10329,ML00000132,CHEMBL3126413,,CC(/C=C/C(C)=C/[C@@H]1Cc2nc(cs2)[C@@H](C)C[C@@H](NC(=O)c2ccccc2)CC(=O)O[C@@H](C)C/C(C)=C/C=C\C(=O)O1)=C\CN(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10330,ML00009033,,,C/C=C(C)/C=C(\C)[C@H](O)[C@@H](C)[C@@H]1OC(=O)/C(CCCCCC)=C\c2csc(n2)[C@@H](C)[C@@H](O)C[C@H](O)/C=C\C=C/C[C@H](O)[C@H]1O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10331,ML00010155,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](C[C@H](O)CO)OC(=O)CCNC(=O)[C@@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10332,ML00007355,,,CC(O)C(=O)N[C@@H]1C(=O)N2NCCC[C@@H]2C(=O)N(O)[C@@H](C)C(=O)NCC(=O)N2NCCC[C@H]2C(=O)N(O)[C@H](C)C(=O)O[C@H]1C(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10333,ML00006133,,,CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCCN(C)C)C(=O)N[C@H]2CC[C@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10334,ML00009485,,,C=C1C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](C[C@@]2(OC)OC(=O)Nc3ccccc32)C(=O)N[C@@H](c2ccc(O)cc2)CC(=O)O[C@@H](C)C[C@@H](C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10335,ML00001012,CHEMBL1487773,,CO[C@@H]1COC(=O)[C@H](C)NC(=O)C/C=C\[C@@H](C)[C@@H](NS(=O)(=O)c2ccc(C)cc2)COC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10336,ML00006491,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CCCCC)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10337,ML00005121,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCNC(=O)c2cc(F)c(F)c(F)c2F)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10338,ML00005702,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@@H](CC[C@H]2O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@@H](O)COP(=O)(O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10339,ML00000747,CHEMBL602559,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](CCCC)NC(=O)OCCC/C=C/c1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10340,ML00000525,CHEMBL1923810,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCNCc2ccc(N3CCOCC3)cc2)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10341,ML00002441,,,C#CCCC[C@@H]1OC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10342,ML00001458,CHEMBL564259,OSCILLAPEPTIN D,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](C[C@H]2C=C[C@H](O)CC2)NC(=O)[C@@H](NC(=O)[C@H](CCc2ccc(O)cc2)NC(=O)[C@@H](COS(=O)(=O)O)OC)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10343,ML00000370,CHEMBL1323656,,CO[C@@H]1COC(=O)[C@H](C)NC(=O)C/C=C\[C@@H](OC)[C@H](C)COC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10344,ML00010048,,,CC1=C[C@@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@@H]([C@H](C)O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@H](C1)[C@H]2[C@]4(C)[C@@]31CO1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10345,ML00002984,,,CCC1NC(=O)C(NC(=O)c2ncccc2O)C(C)OC(=O)C(c2ccccc2)NC(=O)C2CC(=O)CCN2C(=O)C(Cc2ccccc2)N(C)C(=O)C2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10346,ML00005669,,,CCCC(=O)N[C@H](C(=O)N[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H]([C@@H](C)CC)C(=O)N(C)[C@@H](Cc2ccc(OC)c(Br)c2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C)C(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10347,ML00005076,,,C/C=C1\NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10348,ML00003791,,,COC[C@H]1C(=O)NCC(=O)N2N=CCC[C@H]2C(=O)N(O)[C@H](C)C(=O)O[C@@H](C(C)C)[C@H](NC(=O)[C@@](C)(O)[C@]2(O)CC[C@@H](CC(C)C)[C@H](C)O2)C(=O)N2NCCC[C@@H]2C(=O)N1O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10349,ML00005133,,,C/C=C1\NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10350,ML00009460,,,CCCCCCCCCC[C@H]1OC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10351,ML00005090,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC(C)(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10352,ML00007090,,,C/C1=C\CC[C@@H](C)CCO[C@@H]2O[C@H](CO[C@@H]3OC[C@](O)(COC1=O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10353,ML00005693,,,CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@H](Cc2ccccc2)C(=O)N(C)[C@@H](Cc2ccc(O)c(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)O[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10354,ML00001465,CHEMBL562957,MICROPEPTIN 88 Y,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)CC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(C)=O)C(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10355,ML00000808,CHEMBL1773902,COCOSAMIDE B,C#CCCC[C@@H]1OC(=O)CNC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)NC(=O)C1(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10356,ML00005362,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10357,ML00009120,,,CCCCCC[C@H]1OC(=O)CNC(=O)[C@@H]([C@H](C)OC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10358,ML00001429,CHEMBL4066566,,CCCCCCC[C@@H]1CC(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10359,ML00010872,,,CCC(C)C1NC(=O)C2CCCN2C(=O)C(CC(C)C)OC(=O)CCNC(=O)C(C)N(C)C(=O)C(C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10360,ML00005898,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H](CO)OC)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10361,ML00000822,CHEMBL1783106,VERAGUAMIDE B,CC(C)[C@@H]1NC(=O)[C@@H](C)[C@@H](CCCC#CBr)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)C)OC(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10362,ML00000256,CHEMBL1485069,,CO[C@@H]1COC(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)[C@@H](C)NC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10363,ML00001544,CHEMBL413919,OSCILLAPEPTIN B,CC[C@H](C)[C@H]1C(=O)N(C)[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@@H]([C@H](C)CC)C(=O)O[C@H](C)[C@H](NC(=O)[C@H](CCc2ccc(O)cc2)NC(=O)[C@@H](COS(=O)(=O)O)OC)C(=O)N[C@@H](CCc2ccc(OC)cc2)C(=O)N[C@H]2CC[C@@H](O)N1C2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10364,ML00000657,CHEMBL1480885,,CO[C@@H]1COC(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)[C@H]2CCCN2C(=O)C/C=C\[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10365,ML00005672,,,CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H]2CC[C@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10366,ML00005077,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCOC(=O)CCOC(C)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10367,ML00002019,CHEMBL554587,ARENAMIDE B,CCCC[C@H](C)[C@@H]1CC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10368,ML00002855,,,CC[C@@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@H](C)OC(=O)[C@@H](c2ccccc2)NC(=O)[C@H]2CC(=O)CCN2C(=O)[C@H](Cc2ccc(NC)cc2)N(C)C(=O)[C@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10369,ML00000764,CHEMBL1078918,MICROPEPTIN 478-B,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](COS(C)(=O)=O)OS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10370,ML00004934,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10371,ML00009972,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](C[C@H]2CO2)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10372,ML00009818,,,CCCCCC[C@H](C)[C@@H]1CC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10373,ML00009881,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](C[C@@]2(O)C(=O)Nc3ccccc32)N(C)C(=O)[C@@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10374,ML00003909,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3[C@H](CCCN3C)C(=O)N(O)[C@@H](C)C(=O)NCC(=O)N3[C@@H](CCCN3C)C(=O)N(O)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10375,ML00009677,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)c(O)c2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10376,ML00003437,,,CCC1OC(O)(C(C)(O)C(=O)NC2C(=O)N3NCCCC3C(=O)N(O)C(C)C(=O)NCC(=O)N3NCCCC3C(=O)N(O)C(C)C(=O)OC2C(C)C)CCC1CCC(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10377,ML00009883,,,C/C1=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](C[C@@]2(O)C(=O)Nc3ccccc32)N(C)C(=O)C(C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10378,ML00005182,,,CC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10379,ML00005176,,,C/C=C1\NC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3N2C(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10380,ML00011001,,,CC(C)C[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)OCOC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10381,ML00003606,,,C/C=C1/[C@H](O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O[C@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3O)[C@@H]2O)OC=C2C(=O)OCCc3ccc(cc3)Oc3cc(ccc3O)CCOC(=O)C[C@@H]21,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10382,ML00002442,,,C#CCCC[C@@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)OC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10383,ML00001552,CHEMBL269107,LARGAMIDE F,CC(C)[C@H](NC(=O)[C@@H](C)NC(=O)[C@H](CCCc1ccc(O)cc1)NC(=O)[C@H](O)CO)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H]([C@@H](C)O)C(=O)N(C)[C@@H](Cc2ccc(O)c(Br)c2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10384,ML00006278,,,CC[C@H](C)C[C@H]1CC[C@](O)(C(C)(C)C(=O)N[C@@H]2C(=O)N3NCCC[C@H]3C(=O)N(O)[C@@H](C)C(=O)N3NC[C@](C)(O)C[C@@H]3C(=O)[C@@H]3CC[C@](C)(O)[C@@H]3C(=O)N(O)[C@@H](C(C)C)C(=O)O[C@H]2C(C)C)O[C@]1(C)CC,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10385,ML00009887,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10386,ML00005110,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10387,ML00009678,,,C/C1=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)c(O)c2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10388,ML00005479,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@H](C)C(=O)N3NC[C@H](O)C[C@@H]3C(=O)N3CC[C@@](C)(O)[C@H]3C(=O)N(O)[C@@H](C(C)C)C(=O)O[C@H]2C(C)C)O[C@@H]1CC,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10389,ML00010161,,,CC(C)C[C@@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10390,ML00001182,CHEMBL3126407,,CC(/C=C/C(C)=C/[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C=C/C(=O)O1)=C\CN(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10391,ML00006365,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)[O-])OC)C(C)C)[C@@H](C)OC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10392,ML00005088,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](CCC2CCCCC2)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10393,ML00000055,CHEMBL1514398,,CO[C@@H]1COC(=O)CCC[C@@H](C)[C@H](OC)COC(=O)[C@H](Cc2ccccc2)NC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10394,ML00010590,,,C/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OC[C@@H](O)c3ccc(cc3)Oc3cc(ccc3O)CCOC(=O)C[C@H]21,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10395,ML00006357,,,CCCCCC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H]1C(=O)N[C@H](CC(C)C)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10396,ML00000890,CHEMBL256744,MICROPEPTIN 103,CCCCCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](Cc2ccccc2)C(=O)N(C)[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C)[C@@H](C)O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10397,ML00002459,,,CC[C@@H](C)[C@H](NC=O)C(=O)N[C@H]1C(=O)N[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@H](C(C)C)C(=O)N2NC[C@@H](O)C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10398,ML00000529,CHEMBL243279,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCNCc2ccncc2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CCCC(C)C)C(C)C)[C@H](C)O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10399,ML00010314,,,CC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](C[C@H](O)CCl)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10400,ML00005741,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)N(C)C(=O)[C@H]([C@@H](C)O)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC=O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10401,ML00005142,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10402,ML00005172,,,C/C=C1\NC(=O)[C@H](Cc2ccc(F)c(F)c2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)/C=C/c2ccc(C(F)(F)F)cc2)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10403,ML00005061,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)CCCC(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10404,ML00000968,CHEMBL2385897,,CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](O)Cc2ccc(O)cc2)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10405,ML00004951,,,CC[C@@H](C)[C@@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]1CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(=O)N[C@H]1C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)O[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10406,ML00006364,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)O)OC)C(C)C)[C@@H](C)OC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10407,ML00004957,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCNC(=N)N)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10408,ML00010316,,,CC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC2CO2)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10409,ML00003234,,,CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@@H](c2ccccc2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2ccc(N(C)C)cc2)N(C)C(=O)[C@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10410,ML00000255,CHEMBL1325775,,CO[C@@H]1COC(=O)[C@H](C)NC(=O)C/C=C\[C@@H](OC)[C@H](C)COC(=O)CCC[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10411,ML00004402,,,C/C=C/[C@H]1C[C@H]2C(=O)O[C@H](C)[C@@H](NC(=O)[C@H](C[C@@H]3C[C@H]3[N+](=O)[O-])NC(=O)c3ccc(Cl)n3O)C(=O)N[C@@H]([C@H](C)c3ccccc3)C(=O)N[C@H](C[C@@H]3C[C@H]3[N+](=O)[O-])C(=O)N[C@@H]([C@H](C)c3ccccc3)C(=O)N[C@H]([C@@H](C)CC)C(=O)N2C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10412,ML00007130,,,C/C(Br)=C\[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C#CC(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10413,ML00005086,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)CCCC(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10414,ML00003688,,,CCC(C)C(NC=O)C(=O)NC1C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)N2NCCCC2C(=O)NC(CC(C)C)C(=O)N2NCCCC2C(=O)OC1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10415,ML00001620,CHEMBL2338548,LYNGBYASTATIN 8,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(C)=O)C(C)C)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10416,ML00010977,,,CC(/C=C/C(C)=C/[C@@H]1Cc2nc(cs2)[C@@H](C)C[C@@H](N)CC(=O)O[C@@H](C)C/C(C)=C/C=C\C(=O)O1)=C\CN(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10417,ML00009094,,,O=C1OC[C@H]2O[C@@H](O)[C@H](OC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c4oc(=O)c5c(c(O)c(O)c6oc(=O)c3c4c65)-c3c1cc(O)c(O)c3O)[C@@H](O)[C@@H]2O,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10418,ML00005635,,,CCC(C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H]1C(=O)N[C@H](CC(C)C)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10419,ML00010887,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](C[C@@H](C)C(=O)O)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10420,ML00005716,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)O)OC)C(C)C)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10421,ML00003261,,,CC(C)CC1OC(=O)CCNC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10422,ML00006366,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)[O-])OC)C(C)C)[C@@H](C)OC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10423,ML00006362,,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)[O-])OC)C(C)C)[C@@H](C)OC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10424,ML00009562,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(C)C)NC(=O)C[C@H](CCCCCCC(C)C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10425,ML00002054,CHEMBL225269,EMERICELLAMIDE A,CCCCCC[C@H](C)[C@H]1OC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10426,ML00010391,,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC(=O)[C@H](C)CC(=O)OC[C@H](C1)[C@@H]2[C@]4(C)[C@@]31CO1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10427,ML00009675,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)[C@H]1O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10428,ML00005478,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@H](C)C(=O)N3NCCC[C@@H]3C(=O)N3CC[C@@](C)(O)[C@H]3C(=O)N(O)[C@@H](C(C)C)C(=O)O[C@H]2C(C)C)O[C@@H]1CC,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10429,ML00009483,,,COc1ccc([C@H]2CC(=O)O[C@@H](C)C[C@@H](C)/C=C(\C)C[C@@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc3c(Br)[nH]c4ccccc34)C(=O)N2)cc1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10430,ML00005743,,,CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@H](Cc2ccccc2)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10431,ML00000783,CHEMBL1076839,CYANOPEPTOLIN SS,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)O)OS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10432,ML00005473,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@@H](C)C(=O)N3NC[C@H](O)C[C@@H]3C(=O)N3CC[C@@](C)(O)[C@H]3C(=O)N(O)[C@@H](C(C)C)C(=O)O[C@H]2C(C)C)O[C@@H]1CC,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10433,ML00006317,,,CC(C)[C@@H]1NC(=O)[C@@H]2CS(=O)(=O)CS(=O)(=O)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)c3cnc4ccccc4n3)COC1=O)C(=O)N[C@@H](C(C)C)C(=O)OC[C@@H](NC(=O)c1cnc3ccccc3n1)C(=O)N[C@@H](C)C(=O)N2,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10434,ML00009971,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](C[C@@H]2CO2)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10435,ML00003439,,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(OC)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10436,ML00000287,CHEMBL1397858,,CO[C@@H]1COC(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)[C@H](Cc2ccccc2)NC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10437,ML00004349,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](O)CO)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10438,ML00005180,,,CC[C@@H](C)[C@@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]1CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(=O)N[C@H]1C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC(C)(C)C(=O)N[C@@H](C(C)C)C(=O)O[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10439,ML00001550,CHEMBL556531,MICROPEPTIN 88 F,CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@@H]1C)C(=O)OC,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10440,ML00003691,,,COC[C@H]1C(=O)NCC(=O)N2NCCC[C@@H]2C(=O)N(O)[C@H](C)C(=O)O[C@@H](C(C)C)[C@H](NC(=O)[C@](C)(O)[C@]2(O)CC[C@@H](CC(C)C)[C@H](C)O2)C(=O)N2NCCC[C@@H]2C(=O)N1O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10441,ML00002106,CHEMBL1371708,,CO[C@@H]1COC(=O)[C@@H](OCc2ccccc2)/C=C\[C@H](C)[C@@H](OC)COC(=O)[C@@H](CCSC)NC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10442,ML00005084,,,C/C=C1\NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10443,ML00010601,,,Cc1oc(=O)oc1COC(=O)N1C[C@@H]2C[C@H]1C(=O)Nc1cccc(c1)C(=O)OC/C=C\COC(=O)C1=C(S2)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10444,ML00005128,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2Cl)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10445,ML00005671,,,CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10446,ML00004955,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10447,ML00010159,,,CC[C@H](C)[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10448,ML00004285,,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](O)CS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10449,ML00009348,,,C/C1=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@H](Cc2ccc(O)c(I)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10450,ML00001438,CHEMBL256757,MICROPEPTIN SF995,CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H]([C@@H](C)CC)C(=O)N(C)[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10451,ML00009350,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2ccc(O)c(Br)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10452,ML00001072,CHEMBL1476983,,CO[C@@H]1COC(=O)[C@@H](C)NC(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10453,ML00005068,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10454,ML00000940,CHEMBL258219,NOSTOPEPTIN BN920,CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](Cc2ccccc2)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10455,ML00005179,,,CC[C@@H](C)[C@@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]1CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(=O)N[C@H]1C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)O[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10456,ML00004791,,,CCCCCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](Cc2ccccc2)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10457,ML00002835,,,C/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H]2O)OC=C2C(=O)OCCc3ccc(cc3)Oc3cc(ccc3O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)CCOC(=O)C[C@H]21,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10458,ML00005187,,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)C(C)O)C(C)C)C(C)C)C(C)CC)C(C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10459,ML00001372,CHEMBL4076749,,CCCCC[C@@H]1CC(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10460,ML00007373,,,C=CC[C@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10461,ML00000284,CHEMBL453207,LYNGBYABELLIN A,CC[C@H](C)[C@@H]1NC(=O)CNC(=O)c2csc(n2)[C@H](C(C)(C)O)OC(=O)C(C)(C)[C@H](CCCC(C)(Cl)Cl)OC(=O)c2csc1n2,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10462,ML00009676,,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@H]([C@H](O)c2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10463,ML00000851,CHEMBL602986,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10464,ML00001229,CHEMBL3356718,,C=CCCCS(=O)(=O)NC(=O)c1ccccc1NC(=O)[C@H]1NC(=O)[C@H](C(C)(C)C)NC(=O)OCC/C=C/c2cc(nc(-c3ccccc3)n2)Oc2ccc1cc2,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10465,ML00003607,,,C/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H]2O)OC=C2C(=O)OCCc3ccc(cc3)Oc3cc(ccc3O)CCOC(=O)C[C@H]21,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10466,ML00005150,,,C/C=C1\NC(=O)[C@H](Cc2c(F)c(F)c(F)c(F)c2F)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10467,ML00001129,CHEMBL2407690,,CC(C)C[C@@H]1OC(=O)CCNC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2[C@@H](C)CCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10468,ML00000700,CHEMBL605826,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1(C)CCCCC1)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10469,ML00000163,CHEMBL1524593,,CO[C@H]1COC(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)[C@@H](C)COC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10470,ML00005690,,,CCC/C=C/C=C/C(=O)O[C@H]1C2=CC(=O)O[C@@H]2[C@H]2C[C@H](C(C)=O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]4C/C(=C\C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10471,ML00010717,,,C=C/C=C\[C@H](C)[C@H](O)[C@@H](C)[C@H]1CC[C@@H](C)C[C@H](C)[C@@H](O)[C@@H](C)/C=C\[C@@H](O)C[C@H](O)[C@H](C)/C=C/C=C\C(=O)O1,standard_macrolactone,20.0,,,success,,8.0,"[3, 6, 8, 9, 10, 13, 15, 16]",ring_size_20/standard/numbered/ML00010717_numbered.png,2026-03-19 06:59:08.118100
10472,ML00010876,,,CO[C@H]1/C=C\C=C(/C)C(=O)OCc2cn(nn2)C[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)C(=O)O[C@H]1CO[Si](C)(C)C(C)(C)C,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10473,ML00005935,,,CCCC(=O)O[C@H]1C[C@H]2C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@H]3C/C(=C\C(=O)OC)[C@@H](OC(=O)CCC)[C@](O)(O3)C(C)(C)/C=C\[C@H]3C/C(=C\C(=O)OC)C[C@@H](C[C@](O)(O2)C1(C)C)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10474,ML00009187,,,C=C(C)CC(=O)N/C=C/C(C)=C/[C@@H](C)[C@H]1C/C(C)=C\C=C/CC[C@H](OC(N)=O)[C@@H](O)/C=C\[C@@H](O)CCC/C=C\C(=O)O1,standard_macrolactone,20.0,,,success,,5.0,"[3, 5, 11, 12, 15]",ring_size_20/standard/numbered/ML00009187_numbered.png,2026-03-19 06:59:08.167412
10475,ML00005662,,,CO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](OC)[C@@H](O)/C=C(C)/C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](OC)C[C@H](OC)[C@]13CO3)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10476,ML00000194,CHEMBL599873,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC1(CCCCc3cccc4c3CN(C4)C(=O)O2)CCC1)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10477,ML00002772,,,CCCC(=O)O[C@H]1C[C@H]2C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@@H](OC(C)=O)[C@@](O)(O3)C(C)(C)/C=C\[C@H]3C/C(=C/C(=O)OC)C[C@@H](C[C@](O)(O2)C1(C)C)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10478,ML00000815,CHEMBL501873,,CCC[C@H](NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)C(=O)CC1CC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10479,ML00009160,,,CC(C)CC1NC(=O)C(C(C)C)NC(=O)CC(C)COC(=O)C(CC(C)C)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)OC1=O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10480,ML00010178,,,CC[C@@H]1/C=C\[C@H](O)[C@H](C=C(C)C)OC(=O)/C(C)=C\CC(=O)Nc2cc(O)cc3c2O/C(=C\C(=O)CC1)C=C3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10481,ML00005870,,,COC(=O)/C=C1/C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(=O)CC(C)C)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@H](OC(C)=O)[C@@](O)(O3)C(C)(C)/C=C\[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10482,ML00001526,CHEMBL3674588,,CCCCCCCCCCCC/C=C/c1ccc([C@@H]2C[C@@H]3CCO[C@H](/C=C/C(C)(C)[C@]4(O)O[C@@H](C/C(=C\C(=O)OC)[C@@H]4OC(=O)CCCCCCC)C[C@H](CO)OC(=O)C[C@H](O)CCO2)O3)cc1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10483,ML00005804,,,CO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](O)C/C=C(C)/C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](O)C[C@H](OC)[C@@H]1C)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10484,ML00010809,,,CC[C@H]1/C=C\[C@H](O)[C@H](C=C(C)C)OC(=O)/C(C)=C\CC(=O)Nc2cc(O)cc3c2O/C(=C\C(=O)CC1)C(C)=C3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10485,ML00000366,CHEMBL1514135,,CO[C@@H]1COC(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)[C@H](C)COC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10486,ML00001255,CHEMBL454218,IPOMOEASSIN B,C/C=C(\C)C(=O)O[C@@H]1[C@@H](O)[C@H]2O[C@H](COC(=O)CCC(=O)CCCCCC[C@H](CCC)O[C@@H]3O[C@H](C)[C@H](O)[C@H](O)[C@H]3O2)[C@H]1OC(=O)/C=C/c1ccccc1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10487,ML00004721,,,CCCCC[C@H]1CCCCCCCCCC(=O)OC[C@H]2O[C@@H](O[C@@H]3[C@@H](O)[C@@H](O)[C@@H](C)O[C@H]3O1)[C@H](O[C@@H]1O[C@@H](C)[C@H](OC(=O)[C@@H](C)CC)[C@@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@H]1OC(=O)[C@@H](C)CC)[C@@H](O)[C@@H]2O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10488,ML00000743,CHEMBL527062,,C=CC1CC1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)P(C)(=O)O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10489,ML00000586,CHEMBL94864,,O=C1Cn2c(Cl)cnc(c2=O)N[C@@H](Cc2ccccc2)CNC(=O)OC/C=C/COc2ccc(Cl)cc2CN1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10490,ML00002710,,,CC(C)C[C@H]1NC(=O)CO[C@@H]2C/C=C\C=C/C=C\C[C@@H](O)[C@@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@](C)(OC(=O)[C@@H]3C[C@@H](CC[C@H]3O)NC(=O)[C@@H](C(C)C)NC1=O)O[C@@H](C)C2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10491,ML00000728,CHEMBL1256598,,CC1(C)CCCCc2cccc3c2CN(C3)C(=O)O[C@@H]2C[C@@H](C(=O)N[C@@H]3BOCC3)N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)OC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10492,ML00006350,,,CCC/C=C/C=C/C(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]4C/C(=C\C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10493,ML00005823,,,C=C1CC[C@@H]2[C@]3(C)CCC[C@@]2(C)COC(=O)[C@@H]([C@@H](CC(=O)O)C(=O)OC)OC[C@H]2C(=C)CC[C@@H]4[C@]2(C)CCC[C@@]4(C)COC(=O)[C@@H]([C@@H](CC(=O)O)C(=O)OC)OC[C@@H]13,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10494,ML00000195,CHEMBL605613,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC1(CCCCc3cccc4c3CN(C4)C(=O)O2)CC1)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10495,ML00001279,CHEMBL303852,,CC[C@@H]1/C=C(\C)[C@@H](O)[C@H](C)[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10496,ML00002256,,,CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@](C)(C(=O)[C@H](O)C1=C(C)C3C[C@@](O)([C@H](C)OC(=O)CCC/C=C\CCCC(=O)N[C@@H](c4ccccc4)[C@@H](O)C(=O)O3)C1(C)C)C2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10497,ML00005736,,,CCC/C=C/C=C/C(=O)O[C@H]1C2=CC(=O)O[C@@H]2[C@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]4C/C(=C/C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10498,ML00002770,,,CCCC(=O)O[C@H]1C[C@H]2C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@@H](OC(C)=O)[C@@](O)(O3)C(C)(C)/C=C\[C@H]3C/C(=C\C(=O)OC)C[C@@H](C[C@](O)(O2)C1(C)C)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10499,ML00009267,,,COC[C@@H]1C[C@H](OC)[C@@H](O)CC/C=C(C)/C=C/[C@@H](O[C@@H]2O[C@@H](C)[C@H](OC)[C@@H](O)[C@@H]2O)[C@H](C)/C=C(C)/C=C(C)/C=C(\C)C(=O)O1,standard_macrolactone,20.0,,,success,,9.0,"[3, 5, 6, 10, 13, 14, 16, 18, 20]",ring_size_20/standard/numbered/ML00009267_numbered.png,2026-03-19 06:59:08.385976
10500,ML00000707,CHEMBL599875,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10501,ML00001005,CHEMBL1592372,,CSCC[C@@H]1NC(=O)C/C=C\[C@@H](C)COC(=O)[C@@H](CCSC)NC(=O)C/C=C\[C@@H](C)COC1=O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10502,ML00000472,CHEMBL1288515,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)c1cccc2c1COB2O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10503,ML00004653,,,CC[C@@H](C[C@@H](C)C(=O)O)C(=O)CC/C1=C/[C@@H](C)C/C(C)=C\[C@H](C)[C@@H](O)[C@H](C)CC[C@H](CCCC/C=C/[C@H](C)CC[C@H](C)OC(=O)C[C@@H](CC(=O)O)C(=O)O)OC(=O)C[C@@H](C(=O)O)CC(=O)OC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10504,ML00002352,,,COC(=O)/C=C1/C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(=O)C(C)(C)C)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C/C(=O)OC)C[C@@](O)(O3)C(C)(C)/C=C/[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10505,ML00007048,,,CO[C@@H]1COC(=O)C/C=C\[C@@H](C)[C@H](OC)COC(=O)[C@@H](C)COC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10506,ML00005585,,,CO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](O)C/C=C(C)\C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CC[C@H](O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](OC)C[C@H](OC)[C@]13CO3)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10507,ML00011010,,,C=C/C=C\[C@H](C)[C@H](O)[C@H](C)[C@@H]1CC/C=C\[C@H](C)[C@@H](O)[C@@H](C)/C=C\[C@H](O)C[C@H](O)[C@H](C)/C=C\C=C\C(=O)O1,standard_macrolactone,20.0,,,success,,7.0,"[3, 8, 9, 10, 13, 15, 16]",ring_size_20/standard/numbered/ML00011010_numbered.png,2026-03-19 06:59:08.479634
10508,ML00001293,CHEMBL3674583,,CCCCCCCC(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H](CO)OC(=O)C[C@H](O)CCO[C@H](c3ccccc3)C[C@@H]3CCO[C@H](/C=C/C(C)(C)[C@]1(O)O2)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10509,ML00003306,,,COC(=O)/C=C1/C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(C)=O)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)C[C@@](O)(O3)C(C)(C)/C=C\[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10510,ML00002771,,,CCCC(=O)O[C@H]1C[C@H]2C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@H](OC(C)=O)[C@@](O)(O3)C(C)(C)/C=C\[C@H]3C/C(=C/C(=O)OC)C[C@@H](C[C@](O)(O2)C1(C)C)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10511,ML00000470,CHEMBL1288513,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)c1ccc2c(c1)B(O)OC2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10512,ML00006814,,,C[C@@H]1/C=C\CC(=O)OC[C@H]2O[C@@H](C=C[C@@H]2O)[C@H](C)/C=C\CC(=O)OC[C@H]2O[C@H]1C=C[C@@H]2O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10513,ML00001264,CHEMBL3674584,,CCCCCCCC(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H](CO)OC(=O)C[C@H](O)CCO[C@H](c3ccc(Br)cc3)C[C@@H]3CCO[C@H](/C=C/C(C)(C)[C@]1(O)O2)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10514,ML00005867,,,COC(=O)/C=C1\C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(=O)CC(C)C)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@@H](OC(C)=O)[C@@](O)(O3)C(C)(C)/C=C\[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10515,ML00000772,CHEMBL263178,,CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@@H]2OC(=O)C[C@@H](C)CC/C=C/COC(=O)N[C@@H](C=C(C)C)[C@@H](O)C(=O)O[C@H]3CC2(O)C(C)(C)C1=C3C,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10516,ML00006269,,,CCC/C=C/C=C/C(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(=O)CCC)C(C)(C)[C@](O)(C[C@@H]4C/C(=C/C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10517,ML00002870,,,C/C=C(\C)C(=O)O[C@@H]1[C@@H](O)[C@H]2O[C@H](COC(=O)CCC(=O)CCCCCC[C@@H](CCCCC)O[C@@H]3O[C@H](C)[C@H](OC(C)=O)[C@H](O)[C@H]3O2)[C@H]1OC(=O)/C=C/c1ccccc1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10518,ML00007444,,,COc1cc(O)c2c(c1)/C=C/CC(=O)OCc1cccc(c1)COC(=O)CCC[C@H](C)OC2=O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10519,ML00005739,,,CCC/C=C/C=C/C(=O)O[C@H]1[C@H]2C=C3C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]4C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]5C/C(=C\C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(OC(=O)[C@H]2O)O3)O5)O4,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10520,ML00005575,,,CO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](O)C/C=C(C)/C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](OC)C[C@H](OC)[C@]13CO3)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10521,ML00001610,CHEMBL502784,IPOMOEASSIN D,C/C=C(\C)C(=O)O[C@@H]1[C@@H](O)[C@H]2O[C@H](COC(=O)CCC(=O)[C@@H](OC(C)=O)CCCCC[C@H](CCC)O[C@@H]3O[C@H](C)[C@H](OC(C)=O)[C@H](O)[C@H]3O2)[C@H]1OC(=O)/C=C/c1ccccc1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10522,ML00000925,CHEMBL419817,,CC[C@@H]1/C=C(\C)C[C@H](C)[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](Oc4ccc5c(ccn5C)c4)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10523,ML00001636,CHEMBL454231,,C/C=C(\C)C(=O)O[C@@H]1[C@@H](OC(C)=O)[C@H]2O[C@H](COC(=O)CCC(=O)[C@@H](OC(C)=O)CCCCC[C@H](CCC)O[C@@H]3O[C@H](C)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3O2)[C@H]1OC(=O)/C=C/c1ccccc1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10524,ML00005811,,,COC[C@H](O)C[C@H]1O[C@@](O)([C@H](O)[C@@H]2C[C@H](OC)[C@@H](O)CC/C=C(C)/C=C/[C@@H](O[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](O)[C@@H]3O)[C@H](C)/C=C(C)/C=C(C)/C=C(\C)C(=O)O2)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,20.0,,,success,,9.0,"[3, 5, 6, 10, 13, 14, 16, 18, 20]",ring_size_20/standard/numbered/ML00005811_numbered.png,2026-03-19 06:59:08.649431
10525,ML00006159,,,CO[C@H]1C[C@@H]2C=CC[C@H](C[C@@H](OC)[C@]3(CO3)[C@@H](OC)C[C@H](OC)[C@@H](C)[C@@H]([C@H](C)[C@H](OC(C)=O)[C@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@@H](C)/C=C/N(C)C=O)OC(=O)/C=C\C(C)=C/[C@@H]1O)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10526,ML00009987,,,C/C1=C/C(=O)[C@](C)(O)/C=C/C[C@H](C)[C@@H](C[C@H](C)[C@H](C)O)OC(=O)/C=C(/C)[C@@H](C)[C@@H](O)/C=C/C[C@H](O)C1,standard_macrolactone,20.0,,,success,,10.0,"[3, 4, 8, 8, 9, 11, 13, 17, 18, 19]",ring_size_20/standard/numbered/ML00009987_numbered.png,2026-03-19 06:59:08.709333
10527,ML00010697,,,C=C/C=C\[C@H](C)[C@H](O)[C@@H](C)[C@H]1CC[C@H](C)C[C@H](C)[C@@H](O)[C@@H](C)/C=C\[C@@H](O)C[C@H](O)[C@H](C)/C=C/CCC(=O)O1,standard_macrolactone,20.0,,,success,,8.0,"[3, 6, 8, 9, 10, 13, 15, 16]",ring_size_20/standard/numbered/ML00010697_numbered.png,2026-03-19 06:59:08.754820
10528,ML00005735,,,CCC/C=C/C=C/C(=O)O[C@H]1C2=CC(=O)O[C@@H]2[C@H]2C[C@H]([C@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]4C/C(=C\C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10529,ML00002353,,,COC(=O)/C=C1/C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(=O)C(C)(C)C)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)C[C@@](O)(O3)C(C)(C)/C=C\[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10530,ML00005589,,,CO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](O)C/C=C(C)\C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](OC)C[C@H](OC)[C@H]1CO)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10531,ML00006539,,,COC(=O)/C=C1/C[C@@]2(C)C[C@]3(O)O[C@@](C)(C[C@H](OC(=O)C(C)(C)C)C3(C)C)C[C@@H](O)CC(=O)O[C@@](C)([C@@H](C)O)C[C@@]3(C)O[C@](O)(CC4=CC(=O)O[C@@]43C)C(C)(C)/C=C\[C@@](C)(C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10532,ML00001266,CHEMBL506305,IPOMOEASSIN A,C/C=C(\C)C(=O)O[C@@H]1[C@@H](O)[C@H]2O[C@H](COC(=O)CCC(=O)CCCCCC[C@H](CCC)O[C@@H]3O[C@H](C)[C@H](OC(C)=O)[C@H](O)[C@H]3O2)[C@H]1OC(=O)/C=C/c1ccccc1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10533,ML00003438,,,CC[C@@H](C)CC1CCC(O)([C@](C)(O)C(=O)NC2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@@H](C)C(=O)NCCC(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)O[C@H]2C(C)C)OC1C,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10534,ML00001267,CHEMBL505295,IPOMOEASSIN C,C/C=C(\C)C(=O)O[C@@H]1[C@@H](O)[C@H]2O[C@H](COC(=O)CCC(=O)[C@@H](O)CCCCC[C@H](CCC)O[C@@H]3O[C@H](C)[C@H](OC(C)=O)[C@H](O)[C@H]3O2)[C@H]1OC(=O)/C=C/c1ccccc1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10535,ML00005733,,,CCC/C=C/C=C/C(=O)O[C@H]1C2=CC(=O)O[C@@H]2[C@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]4C/C(=C\C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10536,ML00006810,,,C[C@H]1CCC[C@H](O)/C=C\[C@@H]2[C@@H](O)C[C@H](O)C[C@H]2/C=C\C=C/C/C=C\C=C/C(=O)O1,standard_macrolactone,20.0,,,success,,2.0,"[3, 7]",ring_size_20/standard/numbered/ML00006810_numbered.png,2026-03-19 06:59:08.839147
10537,ML00002475,,,CCCC(=O)O[C@H]1C[C@H]2C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)C[C@@](O)(O3)C(C)(C)/C=C\[C@H]3C/C(=C/C(=O)OC)C[C@@H](C[C@](O)(O2)C1(C)C)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10538,ML00002768,,,CCCC(=O)O[C@H]1C[C@H]2C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@H](OC(C)=O)[C@@](O)(O3)C(C)(C)/C=C/[C@H]3C/C(=C\C(=O)OC)C[C@@H](C[C@](O)(O2)C1(C)C)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10539,ML00006537,,,CCCC(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(=O)C(C)(C)C)C(C)(C)[C@](OC)(C[C@@H]4C/C(=C/C(=O)OC)C[C@H](/C=C/C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10540,ML00001473,CHEMBL3674587,,CCCCCC/C=C/c1ccc([C@@H]2C[C@@H]3CCO[C@H](/C=C/C(C)(C)[C@]4(O)O[C@@H](C/C(=C\C(=O)OC)[C@@H]4OC(=O)CCCCCCC)C[C@H](CO)OC(=O)C[C@H](O)CCO2)O3)cc1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10541,ML00000724,CHEMBL1256599,,C[C@H]1COB[C@H]1NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10542,ML00003536,,,C=C[C@@H]1C[C@]1(NC(=O)C1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10543,ML00002773,,,CCCC(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]4C/C(=C/C(=O)OC)C[C@H](/C=C/C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10544,ML00011028,,,C=C1C/C=C\[C@@H](O)[C@@H](O)C(=C)[C@H](O)[C@H](O)C(=C)C/C=C\C(C)=C/C(=O)O[C@@H]([C@H]2O[C@@H]2[C@H](C)CCC)[C@@H](C)C1,standard_macrolactone,20.0,,,success,,10.0,"[3, 4, 6, 10, 11, 12, 13, 14, 15, 19]",ring_size_20/standard/numbered/ML00011028_numbered.png,2026-03-19 06:59:08.937047
10545,ML00000162,CHEMBL1329568,,CO[C@@H]1COC(=O)[C@@H](C)COC(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10546,ML00000949,CHEMBL3581987,,CCCC(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(=O)C(C)(C)C)C(C)(C)[C@](O)(C[C@@H]4C/C(=C/C(=O)OC)C[C@H](/C=C/[C@H](C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10547,ML00004261,,,CCCCCCCC(=O)O[C@H]1/C(=C/C(=O)OC)CC2C[C@H]([C@H](O)CC)OC(=O)C[C@H](O)C[C@@H]3CCC[C@H](C[C@H]4CCO[C@H](/C=C/C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10548,ML00005627,,,CCCC(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(=O)CC(C)C)C(C)(C)[C@](O)(C[C@@H]4C/C(=C/C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10549,ML00010128,,,CO[C@@H]1/C=C\[C@@]2(C)O[C@@H]2C/C=C\C=C(\C)C(=O)[C@@H](C)/C=C(/C)C(=O)O[C@H](/C=C/[C@H]2O[C@@H]2C)[C@H](C)[C@H](O)C1,standard_macrolactone,20.0,,,success,,9.0,"[3, 4, 5, 7, 10, 16, 17, 18, 20]",ring_size_20/standard/numbered/ML00010128_numbered.png,2026-03-19 06:59:09.018918
10550,ML00001238,CHEMBL504071,,CCC[C@H](NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)C(=O)NC(C)c1ccccc1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10551,ML00005868,,,COC(=O)/C=C1\C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(=O)CC(C)C)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@H](OC(C)=O)[C@@](O)(O3)C(C)(C)/C=C\[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10552,ML00007382,,,COC[C@@H]1C[C@H](OC)[C@@H](O)CC/C=C(C)/C=C/[C@@H](O)[C@H](C)/C=C(C)/C=C(C)/C=C(\C)C(=O)O1,standard_macrolactone,20.0,,,success,,9.0,"[3, 5, 6, 10, 13, 14, 16, 18, 20]",ring_size_20/standard/numbered/ML00007382_numbered.png,2026-03-19 06:59:09.091040
10553,ML00005621,,,CCCC(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(=O)CC(C)C)C(C)(C)[C@](O)(C[C@@H]4C/C(=C\C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10554,ML00000738,CHEMBL450002,,C=CC1CC1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)P(=O)(O)O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10555,ML00000236,CHEMBL605825,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC1(CCCCc3cccc4c3CN(C4)C(=O)O2)CCCC1)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10556,ML00000746,CHEMBL591668,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCC/C=C/c1cccc(c1)CN(C)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10557,ML00000723,CHEMBL1256604,,C[C@@H]1COB[C@@H]1NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10558,ML00000797,CHEMBL431090,,CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@@H]2OC(=O)c3cccc(c3)CCCCOC(=O)N[C@@H](CC(C)C)[C@@H](O)C(=O)O[C@H]3C[C@]2(O)C(C)(C)C1=C3C,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10559,ML00002438,,,COC(=O)/C=C1/C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(C)=O)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@H](OC(C)=O)[C@@](O)(O3)C(C)(C)/C=C\[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10560,ML00004608,,,CC(C)C[C@@H](C(=O)N[C@H]1COC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C)COC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)N(C)C1=O)N(C)C,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10561,ML00005936,,,CCCC(=O)O[C@H]1C[C@H]2C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@@H](OC(=O)CCC)[C@@](O)(O3)C(C)(C)/C=C\[C@H]3C/C(=C/C(=O)OC)C[C@@H](C[C@](O)(O2)C1(C)C)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10562,ML00000853,CHEMBL510931,,CCC[C@H](NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)C(=O)NC1CCCC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10563,ML00002351,,,COC(=O)/C=C1\C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(=O)CC(C)C)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)C[C@@](O)(O3)C(C)(C)/C=C\[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10564,ML00005587,,,CO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](O)C/C=C(C)/C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](OC)C[C@H](OC)[C@@H]1CO)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10565,ML00006804,,,CO[C@H]1CC/C=C(\C)C(=O)OCc2cn(nn2)C[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)C(=O)O[C@H]1CO,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10566,ML00001363,CHEMBL321246,,C=CC[C@@H]1/C=C(\C)C[C@H](C)C(=O)OCC(C)(C)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H](CCc2ccccc2)[C@H](C)COC1=O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10567,ML00000795,CHEMBL68027,,C=CC[C@@H]1/C=C(\C)C[C@H](C)[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10568,ML00007155,,,C/C(C=O)=C\[C@@H](C)[C@H]1C/C(C)=C/C=C/CC[C@H](OC(N)=O)[C@@H](O)/C=C/[C@@H](O)CCC/C=C/C(=O)O1,standard_macrolactone,20.0,,,success,,5.0,"[3, 5, 11, 12, 15]",ring_size_20/standard/numbered/ML00007155_numbered.png,2026-03-19 06:59:09.250790
10569,ML00005645,,,CCCC(=O)O[C@@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(=O)CC(C)C)C(C)(C)[C@](O)(C[C@@H]4C/C(=C/C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10570,ML00001440,CHEMBL430809,,CC[C@@H]1/C=C(\C)[C@@H](O)[C@H](C)[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](Oc4ccc5ccccc5c4)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10571,ML00005591,,,CO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](O)C/C=C(C)\C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](OC)C[C@H](OC)[C@@]1(C)O)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10572,ML00000711,CHEMBL600075,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](COC(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10573,ML00010783,,,CO[C@H]1CC/C=C(\C)C(=O)OCc2cn(nn2)C[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)C(=O)O[C@H]1CO[Si](C)(C)C(C)(C)C,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10574,ML00005740,,,CCC/C=C/C=C/C(=O)O[C@H]1[C@H]2C=C3C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]4C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]5C/C(=C/C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(OC(=O)[C@H]2O)O3)O5)O4,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10575,ML00006347,,,CCC/C=C/C=C/C(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](C(C)=O)C(C)(C)[C@](O)(C[C@@H]4C/C(=C/C(=O)OC)C[C@H](/C=C/C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10576,ML00007157,,,C/C1=C/C=C\CC[C@H](OC(N)=O)[C@@H](O)/C=C\[C@H](O)CCC/C=C\C(=O)O[C@@H]([C@H](C)/C=C(\C)C=O)C1,standard_macrolactone,20.0,,,success,,5.0,"[3, 5, 11, 12, 15]",ring_size_20/standard/numbered/ML00007157_numbered.png,2026-03-19 06:59:09.343696
10577,ML00000003,CHEMBL449158,BRYOSTATIN,CCC/C=C/C=C/C(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]4C/C(=C/C(=O)OC)C[C@H](/C=C/C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10578,ML00000099,CHEMBL46252,,CCCCCCCC(=O)O[C@H]1/C(=C/C(=O)OC)CC2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3CCC[C@H](C[C@@H]4CCO[C@H](/C=C/C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10579,ML00001365,CHEMBL511006,,CCC(C)NC(=O)C(=O)C(CC(F)F)NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCCc1cccc3c1CN(C3)C(=O)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10580,ML00000828,CHEMBL1915708,PALMEROLIDE D,C=C(C)C/C(C)=C\C(=O)N/C=C/C(C)=C/[C@@H](C)[C@H]1C/C(C)=C/C=C/CC[C@H](OC(N)=O)[C@@H](O)/C=C/[C@@H](O)CCC/C=C/C(=O)O1,standard_macrolactone,20.0,,,success,,5.0,"[3, 5, 11, 12, 15]",ring_size_20/standard/numbered/ML00000828_numbered.png,2026-03-19 06:59:09.408276
10581,ML00002437,,,COC(=O)/C=C1\C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(C)=O)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@H](OC(C)=O)[C@@](O)(O3)C(C)(C)/C=C\[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10582,ML00010751,,,C=C/C=C\[C@H](C)[C@H](O)[C@@H](C)[C@H]1CC[C@H](C)C[C@H](C)[C@@H](O)[C@@H](C)/C=C\[C@@H](O)C[C@H](O)[C@H](C)CCCCC(=O)O1,standard_macrolactone,20.0,,,success,,8.0,"[3, 6, 8, 9, 10, 13, 15, 16]",ring_size_20/standard/numbered/ML00010751_numbered.png,2026-03-19 06:59:09.468337
10583,ML00005626,,,CCCC(=O)O[C@H]1/C(=C/C(=O)OC)C[C@@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(=O)CC(C)C)C(C)(C)[C@](O)(C[C@@H]4C/C(=C/C(=O)OC)C[C@H](/C=C/C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10584,ML00005926,,,CCC(=O)O[C@H](C)[C@H]1C[C@@H]2C/C(=C/C(=O)OC)C[C@@](O)(O2)C(C)(C)/C=C/[C@H]2C/C(=C\C(=O)OC)C[C@@H](C[C@]3(O)O[C@@H](C[C@H](OC(=O)C(C)(C)C)C3(C)C)C[C@@H](O)CC(=O)O1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10585,ML00002023,CHEMBL419576,,C=CC[C@@H]1/C=C(\C)C[C@H](C)C(=O)OCC(C)(C)C(=O)C(=O)N2CCCC[C@H]2C(=O)OCCCOC1=O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10586,ML00001621,CHEMBL3674585,,CCCCCCCC(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H](CO)OC(=O)C[C@H](O)CCO[C@H](c3ccc(-c4ccccc4)cc3)C[C@@H]3CCO[C@H](/C=C/C(C)(C)[C@]1(O)O2)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10587,ML00007351,,,CCC1/C=C/[C@H](O)[C@H](C)OC(=O)/C(C)=C\CC(=O)NC2=CC(=O)c3c(cc(C)c(O)c3C(=O)CC1)C2=O,non_standard_macrocycle,20.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10588,ML00009184,,,CC(C)=CC(=O)N/C=C/C(C)=C/[C@@H](C)[C@H]1C/C(C)=C\C=C/CC[C@@H](OC(N)=O)[C@@H](O)/C=C\[C@H](O)CCC/C=C\C(=O)O1,standard_macrolactone,20.0,,,success,,5.0,"[3, 5, 11, 12, 15]",ring_size_20/standard/numbered/ML00009184_numbered.png,2026-03-19 06:59:09.547641
10589,ML00002354,,,COC(=O)/C=C1/C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(=O)C(C)(C)C)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@H](O)[C@@](O)(O3)C(C)(C)/C=C\[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10590,ML00000755,CHEMBL1256606,,CC1(C)CCCCc2cccc3c2CN(C3)C(=O)O[C@@H]2C[C@@H](C(=O)N[C@@H]3CCCCOB3O)N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)OC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10591,ML00005590,,,CO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](O)C/C=C(C)/C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](OC)C[C@H](OC)[C@@]1(C)O)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10592,ML00001114,CHEMBL1256605,,CC1(C)CCCCc2cccc3c2CN(C3)C(=O)O[C@@H]2C[C@@H](C(=O)N[C@@H]3CCCOB3O)N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)OC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10593,ML00000687,CHEMBL591648,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCC/C=C/c1cccc3c1CCN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,20.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10594,ML00003422,,,CO[C@@H]1C[C@H](C)O[C@H](CC[C@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C=C\C(C)=C/C[C@H](O)C[C@@H]3C=CC[C@@H](C[C@@H](OC)[C@H](C)[C@@H](O)C[C@H](O)[C@H]2C)O3)C1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10595,ML00009802,,,COc1ccc(COC[C@@H](C)[C@@H](O)C[C@H]2CCC[C@H](OC)C/C=C\C=C\C[C@H](C)[C@@H](O)[C@H](C)[C@@H](O)[C@H](C)[C@H](O)CC(=O)O2)cc1,standard_macrolactone,20.0,,,success,,8.0,"[3, 7, 14, 15, 16, 17, 18, 19]",ring_size_20/standard/numbered/ML00009802_numbered.png,2026-03-19 06:59:09.647662
10596,ML00005584,,,CO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](O)C/C=C(C)\C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](OC)C[C@H](OC)[C@@H]1C)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10597,ML00000199,CHEMBL605620,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10598,ML00010810,,,CC[C@H]1/C=C\[C@H](O)[C@@H](C=C(C)C)OC(=O)/C(C)=C\CC(=O)Nc2cc(O)cc3c2O/C(=C\C(=O)CC1)C(C)=C3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10599,ML00000722,CHEMBL1256601,,CC1(C)CCCCc2cccc3c2CN(C3)C(=O)O[C@@H]2C[C@@H](C(=O)N[C@H]3CCCOB3O)N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)OC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10600,ML00009985,,,C/C1=C/C(=O)[C@](C)(O)/C=C\C[C@@H](C)[C@H](C[C@@H](C)[C@H](C)O)OC(=O)/C=C(/C)[C@H](C)[C@H](O)/C=C\C[C@@H](O)C1,standard_macrolactone,20.0,,,success,,10.0,"[3, 4, 8, 8, 9, 11, 13, 17, 18, 19]",ring_size_20/standard/numbered/ML00009985_numbered.png,2026-03-19 06:59:09.735644
10601,ML00000140,CHEMBL45053,,CCCCCCCC(=O)O[C@H]1/C(=C/C(=O)OC)CC2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)CCO[C@H](C(C)(C)C)C[C@@H]3CCO[C@H](/C=C/C(C)(C)[C@]1(O)O2)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10602,ML00003567,,,CO[C@H](C)CCC[C@@H]1CC/C(C)=C\CC(=O)N[C@H](Cc2ccccc2)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N2CCC[C@@H]2C(=O)O1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10603,ML00000742,CHEMBL1256602,,CC1(C)CCCCc2cccc3c2CN(C3)C(=O)O[C@@H]2C[C@@H](C(=O)N[C@H]3CCCCOB3O)N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)OC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10604,ML00005588,,,CO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](O)C/C=C(C)\C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](OC)C[C@H](OC)[C@@H]1CO)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10605,ML00005901,,,CCC/C=C/C=C/C(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]4C/C(=C/C(=O)OC)C[C@H](/C=C/C[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10606,ML00005586,,,CO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](O)[C@@H](O)/C=C(C)\C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](OC)C[C@H](OC)[C@]13CO3)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10607,ML00001115,CHEMBL1915711,PALMEROLIDE G,CC(C)=CC(=O)N/C=C/C(C)=C\[C@@H](C)[C@H]1C/C(C)=C/C=C/CC[C@H](OC(N)=O)[C@@H](O)/C=C/[C@@H](O)CCC/C=C/C(=O)O1,standard_macrolactone,20.0,,,success,,5.0,"[3, 5, 11, 12, 15]",ring_size_20/standard/numbered/ML00001115_numbered.png,2026-03-19 06:59:09.824712
10608,ML00005583,,,CO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](O)C/C=C(C)/C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](OC)C[C@H](OC)[C@@H]1C)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10609,ML00005211,,,COC[C@@H](C[C@H]1O[C@@](O)([C@H](O)[C@@H]2C[C@H](OC)[C@@H](O)CC/C=C(C)/C=C/[C@@H](O[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](O)[C@@H]3O)[C@H](C)/C=C(C)/C=C(C)/C=C(\C)C(=O)O2)[C@H](C)[C@@H](O)[C@H]1C)O[C@H]1C[C@](C)(O)[C@@H](O[C@H]2C[C@@H](OC)[C@H](O)[C@@H](C)O2)C(C)O1,standard_macrolactone,20.0,,,success,,9.0,"[3, 5, 6, 10, 13, 14, 16, 18, 20]",ring_size_20/standard/numbered/ML00005211_numbered.png,2026-03-19 06:59:09.890278
10610,ML00009914,,,C=C(C)C/C(C)=C\C(=O)N/C=C/C(C)=C/[C@@H](C)[C@H]1C/C(C)=C\C=C/CC[C@H](OC(N)=O)[C@@H](O)/C=C\[C@H](O)CCC/C=C\C(=O)O1,standard_macrolactone,20.0,,,success,,5.0,"[3, 5, 11, 12, 15]",ring_size_20/standard/numbered/ML00009914_numbered.png,2026-03-19 06:59:09.927035
10611,ML00006348,,,CCC/C=C/C=C/C(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2CC([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]4C/C(=C/C(=O)OC)C[C@H](/C=C/C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10612,ML00001268,CHEMBL443118,IPOMOEASSIN E,C/C=C(\C)C(=O)O[C@@H]1[C@@H](O)[C@H]2O[C@H](COC(=O)CCC(=O)[C@@H](OC(C)=O)CCCCC[C@H](CCC)O[C@@H]3O[C@H](C)[C@H](O)[C@H](O)[C@H]3O2)[C@H]1OC(=O)/C=C/c1ccccc1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10613,ML00006352,,,CC[C@@H](O)/C=C/C=C/C(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]4C/C(=C/C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10614,ML00001196,CHEMBL1256603,,CC1(C)CCCCc2cccc3c2CN(C3)C(=O)O[C@@H]2C[C@@H](C(=O)N[C@H]3BOCC3)N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)OC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10615,ML00000805,CHEMBL330975,,CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@](C)(C(=O)[C@H](O)C1=C(C)C3C[C@@](O)([C@H](C)OC(=O)CCCCCCCCC(=O)N[C@@H](c4ccccc4)[C@@H](O)C(=O)O3)C1(C)C)C2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10616,ML00005737,,,CCC/C=C/C=C/C(=O)O[C@H]1C2=CC(=O)O[C@@H]2[C@H]2C[C@H]([C@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]4C/C(=C/C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10617,ML00000786,CHEMBL325279,,CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@@H]2OC(=O)c3cccc(c3)/C=C/CCOC(=O)N[C@@H](C=C(C)C)[C@@H](O)C(=O)O[C@H]3C[C@]2(O)C(C)(C)C1=C3C,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10618,ML00004134,,,CC(C)C[C@@H]1OC(=O)CCCNC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10619,ML00000689,CHEMBL603169,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCC/C=C/c1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10620,ML00006343,,,CCC/C=C/C=C/C(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]4C/C(=C/C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10621,ML00005947,,,C=C1CC[C@@H]2[C@]3(C)CCC[C@@]2(C)COC(=O)[C@@H]([C@H](CC(=O)O)C(=O)OC)OC[C@@H]2C(=C)CC[C@@H]4[C@]2(C)CCC[C@@]4(C)COC(=O)[C@@H]([C@H](CC(=O)OC)C(=O)OC)OC[C@@H]13,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10622,ML00001493,CHEMBL100684,ACTINOPLANIC ACID A,CCC(CC(C)C(=O)O)C(=O)CC/C1=C/C(C)C/C(C)=C/C(C)C(O)C(C)CCC(CCCC/C=C/C(C)CCC(C)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(C(=O)O)CC(=O)OC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10623,ML00000778,CHEMBL450753,,CCC[C@H](NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)C(=O)NCc1ccccc1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10624,ML00009183,,,CC(C)=CC(=O)N/C=C/C(C)=C/[C@@H](C)[C@H]1C/C(C)=C\C=C/CC[C@@H](OC(N)=O)[C@H](O)/C=C\[C@H](O)CCC/C=C\C(=O)O1,standard_macrolactone,20.0,,,success,,5.0,"[3, 5, 11, 12, 15]",ring_size_20/standard/numbered/ML00009183_numbered.png,2026-03-19 06:59:10.051720
10625,ML00000829,CHEMBL506322,,C=CCNC(=O)C(=O)[C@H](CCC)NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCCc1cccc3c1CN(C3)C(=O)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10626,ML00002349,,,COC(=O)/C=C1/C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(=O)CC(C)C)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)C[C@@](O)(O3)C(C)(C)/C=C\[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10627,ML00006349,,,CCC/C=C/C=C/C(=O)OC1/C(=C/C(=O)OC)CC2CC(C(C)O)OC(=O)CC(O)CC3CC(OC(C)=O)C(C)(C)C(O)(CC4C/C(=C/C(=O)OC)CC(/C=C\C(C)(C)C1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10628,ML00000802,CHEMBL70822,,CC[C@@H]1/C=C(\C)C[C@H](C)[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10629,ML00005625,,,CCCC(=O)O[C@H](C)[C@H]1C[C@@H]2C/C(=C/C(=O)OC)C[C@@](O)(O2)C(C)(C)/C=C/[C@H]2C/C(=C\C(=O)OC)C[C@@H](C[C@]3(O)O[C@@H](C[C@H](OC(=O)C(C)(C)C)C3(C)C)C[C@@H](O)CC(=O)O1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10630,ML00005824,,,C=C1CC[C@@H]2[C@]3(C)CCC[C@@]2(C)COC(=O)[C@@H]([C@H](CC(=O)O)C(=O)OC)OC[C@@H]2C(=C)CC[C@@H]4[C@]2(C)CCC[C@@]4(C)COC(=O)[C@@H]([C@H](CC(=O)O)C(=O)OC)OC[C@@H]13,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10631,ML00000135,CHEMBL510416,,C=CC1CC1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)P(=O)(OCC)OCC,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10632,ML00002476,,,CCCC(=O)O[C@H]1C[C@H]2C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)C[C@@](O)(O3)C(C)(C)/C=C\[C@H]3C/C(=C\C(=O)OC)C[C@@H](C[C@](O)(O2)C1(C)C)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10633,ML00000889,CHEMBL302040,,CC[C@@H]1/C=C(\C)C[C@H](C)[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](Oc4ccc5ccccc5c4)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10634,ML00005576,,,CO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](O)[C@@H](O)/C=C(C)/C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](OC)C[C@H](OC)[C@]13CO3)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10635,ML00009915,,,C=C(C)C/C(C)=C\C(=O)N/C=C/C(C)=C/[C@@H](C)[C@H]1C/C(C)=C\C=C/CC[C@H](OC(N)=O)[C@@H](O)/C=C\[C@@H](O)CCC/C=C\C(=O)O1,standard_macrolactone,20.0,,,success,,5.0,"[3, 5, 11, 12, 15]",ring_size_20/standard/numbered/ML00009915_numbered.png,2026-03-19 06:59:10.155313
10636,ML00007350,,,CC[C@@H]1/C=C\[C@H](O)[C@H](C)OC(=O)/C(C)=C\CC(=O)NC2=CC(=O)c3c(cc(C)c(O)c3C(=O)CC1)C2=O,non_standard_macrocycle,20.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10637,ML00010097,,,C/C1=C/C=C\CC[C@@H](C)[C@@H](Cc2cnco2)OC(=O)/C(C)=C\C=C/CC[C@@H](C)[C@@H](Cc2cnco2)OC1=O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10638,ML00000842,CHEMBL506689,,CCC[C@H](NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)C(=O)NC(C)CC,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10639,ML00005812,,,COC[C@H](O)C[C@H]1O[C@@](O)(C[C@@H]2C[C@H](OC)CCC/C=C(C)\C=C/[C@@H](O[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](O)[C@@H]3O)[C@H](C)/C=C(C)\C=C(C)/C=C(/C)C(=O)O2)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,20.0,,,success,,8.0,"[3, 5, 10, 13, 14, 16, 18, 20]",ring_size_20/standard/numbered/ML00005812_numbered.png,2026-03-19 06:59:10.224998
10640,ML00001489,CHEMBL3278746,,CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)OC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10641,ML00000744,CHEMBL1256600,,CC1(C)CCCCc2cccc3c2CN(C3)C(=O)O[C@@H]2C[C@@H](C(=O)N[C@@H]3BOC[C@@H]3C3CC3)N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)OC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10642,ML00007163,,,C/C=C1/[C@H]2OC=C(C(=O)OC)[C@H]1CC(=O)OCC[C@H](C)CC/C=C(/C)C(=O)OC[C@H]1O[C@@H](O2)[C@H](O)[C@@H](O)[C@@H]1O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10643,ML00000182,CHEMBL46053,,CCCCCCCC(=O)O[C@H]1/C(=C/C(=O)OC)CC2C[C@H]([C@@H](C)O)OC(=O)C[C@@H](O)C[C@@H]3CCC[C@H](C[C@@H]4CCO[C@H](/C=C/C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10644,ML00005871,,,COC(=O)/C=C1/C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(=O)CC(C)C)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@H]3C/C(=C\C(=O)OC)[C@H](OC(C)=O)[C@@](O)(O3)C(C)(C)/C=C/[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10645,ML00002769,,,CCCC(=O)O[C@H]1C[C@H]2C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@H](OC(C)=O)[C@@](O)(O3)C(C)(C)/C=C\[C@H]3C/C(=C\C(=O)OC)C[C@@H](C[C@](O)(O2)C1(C)C)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10646,ML00002133,,,C=C1CC[C@@H]2[C@]3(C)CCC[C@@]2(C)COC(=O)[C@@H]([C@@H]2CCOC2=O)OC[C@H]2C(=C)CC[C@@H]4[C@]2(C)CCC[C@@]4(C)COC(=O)[C@@H]([C@@H]2CCOC2=O)OC[C@@H]13,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10647,ML00001585,CHEMBL2032109,,C=C1C[C@H]2C[C@@H]3O[C@@H](CC(=C)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@H](OC(=O)/C=C/C=C/CCC)[C@@](O)(O3)C(C)(C)/C=C/[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10648,ML00009188,,,CC(C)=CC(=O)N/C=C/C(C)=C/[C@@H](C)[C@@H]1C/C(C)=C\C=C/CCC[C@H](OC(N)=O)[C@@H](O)[C@@H](O)/C=C\CC/C=C\C(=O)O1,standard_macrolactone,20.0,,,success,,5.0,"[3, 5, 12, 13, 14]",ring_size_20/standard/numbered/ML00009188_numbered.png,2026-03-19 06:59:10.330083
10649,ML00009984,,,C/C1=C/C(=O)[C@](C)(O)/C=C\C[C@H](C)[C@@H](C[C@H](C)[C@H](C)O)OC(=O)/C=C(/C)[C@@H](C)[C@@H](O)/C=C\C[C@H](O)C1,standard_macrolactone,20.0,,,success,,10.0,"[3, 4, 8, 8, 9, 11, 13, 17, 18, 19]",ring_size_20/standard/numbered/ML00009984_numbered.png,2026-03-19 06:59:10.390256
10650,ML00001969,CHEMBL509136,,C=C[C@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10651,ML00000191,CHEMBL599874,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC1(CCCCC1)CCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10652,ML00000292,CHEMBL407426,,CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@@H]2OC(=O)C[C@@H](C)CC/C=C/COC(=O)N[C@@H](C=C(C)C)[C@@H](O)C(=O)O[C@H]3C[C@]2(O)C(C)(C)C1=C3C,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10653,ML00000991,CHEMBL94413,,O=C1Cn2c(Cl)cnc(c2=O)N[C@@H](Cc2ccccc2)CNC(=O)OCCCCOc2ccc(Cl)cc2CN1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10654,ML00008497,,,O=C1CCCCCCCCCCCCCCC(=O)O[C@H](CO)CO1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10655,ML00005551,,,CO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](O)C/C=C(C)\C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](OC)C[C@H](OC)[C@]13CO3)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10656,ML00000471,CHEMBL1288514,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)c1ccc2c(c1)COB2O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10657,ML00005857,,,COC(=O)/C=C1/C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(=O)C(C)(C)C)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)OC(C)=O)C[C@@H]3C/C(=C/C(=O)OC)C[C@@](O)(O3)C(C)(C)/C=C/[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10658,ML00001277,CHEMBL501262,BRYOSTATIN 10,COC(=O)/C=C1/C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(=O)C(C)(C)C)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)C[C@@](O)(O3)C(C)(C)/C=C/[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10659,ML00009185,,,CC(C)=CC(=O)N/C=C/C(C)=C/[C@@H](C)[C@H]1C/C(C)=C\C=C/CC[C@H](OC(N)=O)[C@@H](O)/C=C\[C@@H](O)CCC/C=C\C(=O)O1,standard_macrolactone,20.0,,,success,,5.0,"[3, 5, 11, 12, 15]",ring_size_20/standard/numbered/ML00009185_numbered.png,2026-03-19 06:59:10.501408
10660,ML00005578,,,CO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](O)C/C=C(C)/C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](OC)C[C@H](OC)[C@]13CO3)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10661,ML00007156,,,C/C1=C/C=C\CC[C@H](OC(N)=O)[C@@H](O)/C=C\[C@@H](O)CCC/C=C\C(=O)O[C@@H]([C@H](C)/C=C(\C)C=O)C1,standard_macrolactone,20.0,,,success,,5.0,"[3, 5, 11, 12, 15]",ring_size_20/standard/numbered/ML00007156_numbered.png,2026-03-19 06:59:10.549583
10662,ML00009986,,,C/C1=C/C(=O)[C@@](C)(O)/C=C\C[C@@H](C)[C@@H](C[C@@H](C)[C@H](C)O)OC(=O)/C=C(/C)[C@H](C)[C@@H](O)/C=C\C[C@H](O)C1,standard_macrolactone,20.0,,,success,,10.0,"[3, 4, 8, 8, 9, 11, 13, 17, 18, 19]",ring_size_20/standard/numbered/ML00009986_numbered.png,2026-03-19 06:59:10.610512
10663,ML00001116,CHEMBL1915710,PALMEROLIDE F,C=C(C)CC(=O)N/C=C/C(C)=C/[C@@H](C)[C@H]1C/C(C)=C/C=C/CC[C@H](OC(N)=O)[C@@H](O)/C=C/[C@@H](O)CCC/C=C/C(=O)O1,standard_macrolactone,20.0,,,success,,5.0,"[3, 5, 11, 12, 15]",ring_size_20/standard/numbered/ML00001116_numbered.png,2026-03-19 06:59:10.652026
10664,ML00000896,CHEMBL303180,,CC[C@@H]1/C=C(\C)[C@@H](O)[C@H](C)[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](Oc4ccc5c(ccn5C)c4)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10665,ML00002709,,,CC(C)C[C@@H]1NC(=O)CO[C@H]2C/C=C\C=C/C=C\C[C@H](O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@](C)(OC(=O)[C@H]3C[C@H](CC[C@@H]3O)NC(=O)[C@@H](C(C)C)NC1=O)O[C@H](C)C2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10666,ML00000846,CHEMBL506565,,CCC[C@H](NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)C(=O)NCc1ccccn1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10667,ML00007312,,,C[C@@H]1Cc2cc(O)cc(O)c2C(=O)O[C@H](C)CC(=O)O[C@H](C)Cc2cc(O)cc(O)c2C(=O)O[C@H](C)CC(=O)O1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10668,ML00005933,,,CCCC(=O)O[C@H]1C[C@H]2C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@@H](OC(=O)CCC)[C@@](O)(O3)C(C)(C)/C=C\[C@H]3C/C(=C\C(=O)OC)C[C@@H](C[C@](O)(O2)C1(C)C)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10669,ML00010580,,,C=C1C[C@@H](O)/C=C\[C@H](CCC(=C)[C@@H](C)[C@H](C)O)OC(=O)[C@H](C)[C@H](C)/C=C\C[C@@H](O)CC[C@@H](O)C[C@H](O)[C@H]1C,standard_macrolactone,20.0,,,success,,9.0,"[3, 6, 8, 9, 10, 12, 15, 19, 20]",ring_size_20/standard/numbered/ML00010580_numbered.png,2026-03-19 06:59:10.745230
10670,ML00006395,,,CO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](OC)[C@@H](O)/C=C(C)/C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](OC)C[C@H](OC)[C@@H]1CO)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10671,ML00010878,,,CCC(=O)CCC[C@H]1OC(=O)/C=C\C=C/C[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\[C@@H](C)C[C@@H]1C,standard_macrolactone,20.0,,,success,,9.0,"[3, 4, 6, 8, 10, 11, 12, 13, 15]",ring_size_20/standard/numbered/ML00010878_numbered.png,2026-03-19 06:59:10.800227
10672,ML00010716,,,CC(C)CC1C(=O)C2CC(CN2)C(=O)NC(C(C)C)C(=O)OC(C(C)C)C(=O)N2NCCCC2C(=O)N2CC(CCN2)C(=O)N1C,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10673,ML00005869,,,COC(=O)/C=C1/C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(=O)CC(C)C)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@@H](OC(C)=O)[C@@](O)(O3)C(C)(C)/C=C\[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10674,ML00000975,CHEMBL71849,,CC[C@@H]1/C=C(\C)C[C@H](C)[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](Oc4ccccc4)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10675,ML00000841,CHEMBL455095,,CCC[C@H](NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)C(=O)NC1CCC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10676,ML00001657,CHEMBL525977,,C/C=C(\C)C(=O)O[C@@H]1[C@@H](OC(C)=O)[C@H]2O[C@H](COC(=O)CCC(=O)CCCCCC[C@H](CCC)O[C@@H]3O[C@H](C)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3O2)[C@H]1OC(=O)/C=C/c1ccccc1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10677,ML00000684,CHEMBL503228,,C=CC1CC1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)P(=O)(O)OCC,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10678,ML00000962,CHEMBL431360,,CC[C@@H]1/C=C(\C)C[C@H](C)[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](Oc4ccc5[nH]ccc5c4)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10679,ML00007321,,,COc1cc(O)c2c(c1)/C=C/CC(=O)OCCC1(CCCCC1)CCOC(=O)CCC[C@H](C)OC2=O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10680,ML00005774,,,C=CC[C@@H]1/C=C(/C)C[C@H](C)[C@H](OC)[C@@H]2O[C@@](O)(C(=O)C(=O)N3CCCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10681,ML00010785,,,CC[C@H](O)CCC[C@H]1OC(=O)/C=C\C=C/C[C@@H](O)C[C@H](O)[C@@H](C)[C@H](O)[C@H](C)C/C(C)=C\[C@@H](C)C[C@@H]1C,standard_macrolactone,20.0,,,success,,9.0,"[3, 4, 6, 8, 10, 11, 12, 13, 15]",ring_size_20/standard/numbered/ML00010785_numbered.png,2026-03-19 06:59:10.910267
10682,ML00006353,,,CC[C@@H](O)/C=C/C=C/C(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]4C/C(=C\C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10683,ML00006538,,,COC(=O)/C=C1\C[C@@]2(C)C[C@]3(O)O[C@@](C)(C[C@H](OC(=O)C(C)(C)C)C3(C)C)C[C@@H](O)CC(=O)O[C@@](C)([C@@H](C)O)C[C@@]3(C)O[C@](O)(CC4=CC(=O)O[C@@]43C)C(C)(C)/C=C\[C@@](C)(C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10684,ML00005212,,,COC[C@@H](C[C@H]1O[C@@](O)([C@H](O)[C@@H]2C[C@H](OC)[C@@H](O)CC/C=C(C)/C=C/[C@@H](O[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](O)[C@@H]3O)[C@H](C)/C=C(C)/C=C(C)/C=C(\C)C(=O)O2)[C@H](C)[C@@H](O)[C@H]1C)OC1C[C@](C)(O)[C@@H](O[C@H]2C[C@@H](OC)[C@H](O)[C@@H](C)O2)[C@H](C)O1,standard_macrolactone,20.0,,,success,,9.0,"[3, 5, 6, 10, 13, 14, 16, 18, 20]",ring_size_20/standard/numbered/ML00005212_numbered.png,2026-03-19 06:59:10.981850
10685,ML00000759,CHEMBL434987,,CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@@H]2OC(=O)C[C@@H](C)CCCCCOC(=O)N[C@@H](CC(C)C)[C@@H](O)C(=O)O[C@H]3CC2(O)C(C)(C)C1=C3C,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10686,ML00005738,,,CCC/C=C/C=C/C(=O)O[C@H]1[C@@H]2C=C3C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]4C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]5C/C(=C\C(=O)OC)C[C@H](/C=C\C(C)(C)[C@@]1(OC(=O)[C@@H]2O)O3)O5)O4,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10687,ML00010476,,,C/C1=C/C=C\CC[C@@H](C)[C@@H](Cc2cnco2)OC(=O)/C=C\C=C/CC[C@@H](C)[C@@H](Cc2cnco2)OC1=O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10688,ML00000006,CHEMBL599872,VANIPREVIR,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10689,ML00000854,CHEMBL504783,,CCC[C@H](NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCCCCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)C(=O)CC1CC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10690,ML00005646,,,CCCC(=O)O[C@@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(=O)CC(C)C)C(C)(C)[C@](O)(C[C@@H]4C/C(=C\C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10691,ML00005213,,,COC[C@@H](C[C@H]1O[C@@](O)([C@H](O)[C@@H]2C[C@H](OC)[C@@H](O)CC/C=C(C)/C=C/[C@@H](O[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](O)[C@@H]3O)[C@H](C)/C=C(C)/C=C(C)/C=C(\C)C(=O)O2)[C@H](C)[C@@H](O)[C@H]1C)O[C@H]1C[C@](C)(O)[C@@H](O[C@H]2C[C@@H](OC)[C@H](O)[C@@H](C)O2)[C@H](C)O1,standard_macrolactone,20.0,,,success,,9.0,"[3, 5, 6, 10, 13, 14, 16, 18, 20]",ring_size_20/standard/numbered/ML00005213_numbered.png,2026-03-19 06:59:11.080597
10692,ML00005683,,,CCC/C=C/C=C/C(=O)O[C@H]1C2=CC(=O)O[C@@H]2[C@H]2C[C@H](C(C)=O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]4C/C(=C/C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10693,ML00002440,,,COC(=O)/C=C1/C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(=O)C(C)(C)C)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@H]3O[C@](O)(CC4=CC(=O)O[C@@H]43)C(C)(C)/C=C\[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10694,ML00002355,,,COC(=O)/C=C1\C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(=O)C(C)(C)C)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@H](O)[C@@](O)(O3)C(C)(C)/C=C\[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10695,ML00003305,,,COC(=O)/C=C1\C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(C)=O)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)C[C@@](O)(O3)C(C)(C)/C=C\[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10696,ML00001637,CHEMBL3674586,,CCCCCCCC(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H](CO)OC(=O)C[C@H](O)CCO[C@H](c3ccc(CCCOCCOCC)cc3)C[C@@H]3CCO[C@H](/C=C/C(C)(C)[C@]1(O)O2)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10697,ML00007314,,,CC[C@H]1/C=C\[C@H](O)[C@H](C)OC(=O)/C(C)=C\CC(=O)NC2=CC(=O)c3c(cc(C)c(O)c3C(=O)CC1)C2=O,non_standard_macrocycle,20.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10698,ML00001291,CHEMBL333927,,CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@](C)(C(=O)[C@H](O)C1=C(C)C3C[C@@](O)([C@H](C)OC(=O)CCC/C=C/CCCC(=O)N[C@@H](c4ccccc4)[C@@H](O)C(=O)O3)C1(C)C)C2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10699,ML00009186,,,CC(C)=CC(=O)N/C=C/C(C)=C/[C@@H](C)[C@H]1C/C(C)=C/C=C/CC[C@H](OC(N)=O)[C@@H](O)/C=C/[C@@H](O)CCC/C=C/C(=O)O1,standard_macrolactone,20.0,,,success,,5.0,"[3, 5, 11, 12, 15]",ring_size_20/standard/numbered/ML00009186_numbered.png,2026-03-19 06:59:11.168308
10700,ML00009182,,,CC(C)=CC(=O)N/C=C/C(C)=C\[C@@H](C)[C@H]1C/C(C)=C\C=C/CC[C@H](OC(N)=O)[C@@H](O)/C=C\[C@@H](O)CCC/C=C\C(=O)O1,standard_macrolactone,20.0,,,success,,5.0,"[3, 5, 11, 12, 15]",ring_size_20/standard/numbered/ML00009182_numbered.png,2026-03-19 06:59:11.209162
10701,ML00003538,,,CC[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10702,ML00011029,,,C=C1C/C=C/[C@H](O)[C@@H](O)C(=C)[C@@H](O)[C@H](O)C(=C)C/C=C/C(C)=C/C(=O)O[C@H]([C@@H]2O[C@H]2[C@@H](C)CCC)[C@@H](C)C1,standard_macrolactone,20.0,,,success,,10.0,"[3, 4, 6, 10, 11, 12, 13, 14, 15, 19]",ring_size_20/standard/numbered/ML00011029_numbered.png,2026-03-19 06:59:11.276036
10703,ML00000604,CHEMBL94952,,O=C1Cn2c(Cl)cnc(c2=O)N[C@@H](Cc2ccccc2)CNC(=O)OC/C=C\COc2ccc(Cl)cc2CN1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10704,ML00006394,,,CO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](OC)[C@@H](O)/C=C(C)\C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](OC)C[C@@H](OC)[C@@H]1CO)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10705,ML00001274,CHEMBL509516,BRYOSTATIN 16,COC(=O)/C=C1/C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(=O)C(C)(C)C)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)C=C(O3)C(C)(C)/C=C/[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10706,ML00002633,,,CCCCCCCC(=O)O[C@H]1/C(=C/C(=O)OC)CC2C[C@H]([C@@H](CC)OC)OC(=O)C[C@H](O)C[C@@H]3CCC[C@H](C[C@H]4CCO[C@H](/C=C/C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10707,ML00000353,CHEMBL1513824,,CO[C@H]1COC(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)[C@H](C)COC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10708,ML00002167,,,COC(=O)/C=C1\C=C2O[C@@H](C1)C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]1C[C@H](OC(=O)C(C)(C)C)C(C)(C)[C@](O)(C[C@@H]3C/C(=C/C(=O)OC)C[C@H](/C=C/C2(C)C)O3)O1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10709,ML00006268,,,CCC/C=C/C=C/C(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(=O)CCC)C(C)(C)[C@](O)(C[C@@H]4C/C(=C\C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10710,ML00002439,,,COC(=O)/C=C1/C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(C)=O)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@H](OC(C)=O)[C@@](O)(O3)C(C)(C)/C=C/[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
10711,ML00005343,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)C[C@H](O)[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3[C@@H](C)C(=O)C[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C)C(=O)O[C@H]2CO)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10712,ML00004921,,,Cc1ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2c1Oc1c(c(C(=O)N[C@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]3C)c3nc(-c4ccc(Cl)cc4Cl)c(=O)oc3c1C)N2,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10713,ML00005401,,,Cc1c2oc3c(C)cnc(C(=O)NC4C(=O)NC(C(C)C)C(=O)N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)c3nc-2c(C(=O)NC2C(=O)NC(C(C)C)C(=O)N3CCCC3C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10714,ML00000522,CHEMBL3218172,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N\OCc5cc(OC)c(OC)c(OC)c5)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N/OCc2cc(OC)c(OC)c(OC)c2)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10715,ML00004685,,,CCCCCc1c(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/CCc4cccc(c4)CC4CC(CCC4=O)C3(O)CCC)C2)cc1NCC(C)O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10716,ML00005272,,,CCCCCc1c(CO)cc(C2C#CC3CC(=O)Oc4c3cc(c(O)c4C3C=CC=CC3)CC3OC(=O)/C(=C/C(O)Cc4cccc(c4)CC4CC(CCC4=O)C3(O)CCC)C2)cc1NCC(C)O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10717,ML00006003,,,COC(=O)C[C@@H]1C(=O)CC[C@H](C)C(=O)O[C@H]2[C@@H](OC(C)=O)[C@]3(COC1=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(=O)[C@](C)(O)[C@H](C)c4ccncc4C(=O)OC[C@]4(C)O[C@@]3([C@H](OC(C)=O)[C@@H]24)[C@@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10718,ML00005049,,,CCCCNc1c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c2nc3c(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)ccc(C)c3oc-2c(C)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10719,ML00005071,,,CC[C@@H]1OC(=O)C[C@H](O)[C@@H](C)[C@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@H](CCNCC[C@H]2C[C@@H](C)C(=O)/C=C/C(C)=C/C(COC3OC(C)C(O)C(OC)C3OC)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]2OC2OC(C)C(O)C(N(C)C)C2O)C[C@H](C)C(=O)/C=C/C(C)=C/C1COC1OC(C)C(O)C(OC)C1OC,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10720,ML00004773,,,CC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/C(O)C4(CCCC4)c4cccc(c4)CC4C(=O)CCC5C4CCCC35O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10721,ML00005029,,,CCc1nc2c(C(=O)N[C@@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]3C)c3c(c(C)c2oc1=O)Oc1c(C)ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c1N3,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10722,ML00005419,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(CO)cc(NCC(C)(O)CCOC5CCCC5)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5C4CCCCC4)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10723,ML00006499,,,COCCC(C)(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/CCc4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10724,ML00004966,,,CCCCCCCCCCCNc1c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c2nc3c(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)ccc(C)c3oc-2c(C)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10725,ML00006833,,,C[C@H]1CCCCC[C@@H](O)C(=O)[C@H](S[C@@H]2CC(=O)O[C@@H](C)CCCCC[C@@H](O)C2=O)CC(=O)O1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10726,ML00004986,,,Cc1c2oc3c(C)c(OCC4CN4)cc(C(=O)NC4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)NC2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10727,ML00004978,,,CCN1CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)c2c3c(c(C)c4oc(=O)c(-c5ccccc5)nc24)Oc2c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c2N3)C(=O)N[C@H](C(C)C)C(=O)N2CCC[C@H]2C1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10728,ML00004976,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(NCCCCCCCCCCN)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10729,ML00000899,CHEMBL4073368,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)C[C@H](O)[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CC(=O)C[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10730,ML00000328,CHEMBL2369146,,Cc1c2oc3c(C)c(OCC4CO4)cc(C(=O)N[C@@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10731,ML00004531,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(CCCC3)C(O)/C=C3\CC(c4cc(CO)cc(NCC(C)O)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5C4C=CC=CC4)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10732,ML00005023,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(NCCCCCN)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10733,ML00001503,CHEMBL2369550,,CC[C@@H](C)[C@H]1NC(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)c2c3nc4c(C(=O)N[C@@H]5C(=O)N[C@H]([C@H](C)CC)C(=O)N6CCC[C@H]6C(=O)N(C)CC(=O)N[C@H]([C@H](C)CC)C(=O)O[C@@H]5C)ccc(C)c4oc-3c(C)c(=O)c2N)[C@@H](C)OC1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10734,ML00006087,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC/C=C3\CC(c4cc(NCC(C)O)cc(C(O)CNC)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10735,ML00004697,,,C/C=C1\NC(=O)[C@H]([C@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H]2CC(=O)O[C@H](C(=O)O)[C@H](NC1=O)C(=O)N[C@@H]([C@H](O)CCl)C(=O)OC[C@H](NC(=O)C[C@H](O)CCCCCCCCCCC)C(=O)N[C@H](CCN)C(=O)N2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10736,ML00005440,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H]([C@H](C)O)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10737,ML00004925,,,Cc1c2oc3c(C)c(OC(=O)Cc4ccc(Cl)c(Cl)c4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10738,ML00004929,,,Cc1c2oc3c(C)c(NCc4ccc(C(F)(F)F)cc4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10739,ML00002934,,,CC1(O)C2CCC(=O)C(Cc3ccc4c(c3)CC(O)/C(=C3\CC(c5cc(O)cc(CO)c5)C#CC5CC(=O)Oc6cc(O)c(cc65)CC1OC3=O)CC4)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10740,ML00005713,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(O)cc(C(O)CNC)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10741,ML00006325,,,CC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C4\CCc5ccc(cc5CC4)CC4CC(CCC4=O)C3(C)O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10742,ML00005109,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N\OCc5ccccc5)[C@H](C)C[C@@]4(C)O)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10743,ML00005408,,,Cc1c2oc3c(C)ccc(C(=O)NC4C(=O)NC(C(C)C)C(=O)N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)O)C(=O)OC4C)c3nc-2c(C(=O)NC2C(=O)NC(C(C)C)C(=O)N3CCCC3C(=O)N(C)CC(=O)N(C)C(C(C)O)C(=O)OC2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10744,ML00005021,,,Cc1c2oc3c(C)c(NCc4ccccn4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10745,ML00006309,,,CCCCCc1ccc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/CCc4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)cc1CO,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10746,ML00005019,,,CCN1CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)c2c3c(c(C)c4oc(=O)c(CF)nc24)Oc2c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c2N3)C(=O)N[C@H](C(C)C)C(=O)N2CCC[C@H]2C1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10747,ML00001513,CHEMBL2372241,,COc1ccc(C[C@H]2NC(=O)CN(C)C(=O)[C@@H]3CCCN3C(=O)[C@@H](C(C)C)NC(=O)[C@@H](NC(=O)c3c4nc5c(C(=O)N[C@@H]6C(=O)N[C@H](C(C)C)C(=O)N7CCC[C@H]7C(=O)N(C)CC(=O)N[C@H](Cc7ccc(OC)cc7)C(=O)O[C@@H]6C)ccc(C)c5oc-4c(C)c(=O)c3N)[C@@H](C)OC2=O)cc1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10748,ML00000912,CHEMBL439714,,Cc1c2oc3c(C)c4oc(-c5ccccc5)nc4c(C(=O)N[C@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10749,ML00004998,,,Cc1c2oc3c(C)c(OCC(C)N)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10750,ML00005009,,,CCC(C)C1NC(=O)C(NC(=O)c2c3nc4c(C(=O)NC5C(=O)NC(C(C)CC)C(=O)N6CCCC6C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC5C)ccc(C)c4oc-3c(C)c(=O)c2O)C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10751,ML00005366,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10752,ML00000923,CHEMBL602573,,Cc1c2oc3c(C)ccc(C(=O)NC4C(=O)N[C@@H](C(C)C)C(=O)N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)c3nc-2c(C(=O)NC2C(=O)N[C@H](C(C)C)C(=O)N3CCCC3C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10753,ML00004930,,,Cc1c2oc3c(C)c(NCc4ccc(C(F)(F)F)cc4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10754,ML00005015,,,Cc1c2oc3c(C)ccc(C(=O)NC4C(=O)NC(C(C)C)C(=O)N5CCCC5C(=O)N(C)CC(=O)N(C)C(Cc5cnc[nH]5)C(=O)OC4C)c3nc-2c(C(=O)NC2C(=O)NC(C(C)C)C(=O)N3CCCC3C(=O)N(C)CC(=O)N(C)C(Cc3cnc[nH]3)C(=O)OC2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10755,ML00001501,CHEMBL2373069,,CC[C@H](C)[C@@H]1NC(=O)[C@@H](NC(=O)c2ccc(C)c3oc4c(C)c(=O)c(N)c(C(=O)N[C@@H]5C(=O)N[C@@H](C(C)C)C(=O)N6CCC[C@H]6C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]5C)c-4nc23)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10756,ML00006312,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC/C=C3\CC(c4cc(CO)cc(NCC(C)O)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10757,ML00004626,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](OC(=O)CSSCC(=O)O[C@H]2[C@@H](C)CCC[C@H]3O[C@H]3C[C@@H](/C(C)=C/c3csc(C)n3)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@@H]2C)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10758,ML00006171,,,CCCCCc1c(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/CCc4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)cc1NCC(C)O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10759,ML00001517,CHEMBL3221806,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(=O)N(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]4(C)O)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10760,ML00000532,CHEMBL3219221,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)[C@@H](O)[C@H](C)C[C@@]4(C)O)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10761,ML00004372,,,CCCC1(O)C2CCC(=O)C(Cc3ccc4c(c3)CC(O)/C(=C3\CC(c5cc(CO)cc(NCC(C)O)c5)C#CC5CC(=O)Oc6c5cc(c(O)c6C5C=CC=CC5)CC1OC3=O)CC4)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10762,ML00004682,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(C/C=C4\CC(c5cc(CO)cc(NCC(C)O)c5)C#CC5CC(=O)Oc6cc(O)c(cc65)CC1OC4=O)CCCCC3)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10763,ML00000423,CHEMBL437538,,C/C=C1\NC(=O)[C@H]2NC(=O)[C@@H](NC(=O)C(C)C)CCCNC(=O)Nc3cc(O)c(O)cc3C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)O[C@H]2C)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10764,ML00004367,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(NCC(C)O)cc(C(O)CNC)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5C4CCCCC4)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10765,ML00004373,,,CCCC1(O)C2CCC(=O)C(Cc3ccc4c(c3)CC(O)/C(=C3\CC(c5cc(CO)cc(NCC(C)O)c5)C#CC5CC(=O)Oc6c5cc(c(O)c6C5CCCCC5)CC1OC3=O)CC4)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10766,ML00006094,,,CCCC1(O)C2CCC(=O)C(Cc3ccc4c(c3)CC/C(=C3\CC(c5cc(CO)cc(NCC(C)O)c5)C#CC5CC(=O)Oc6cc(O)c(cc65)CC1OC3=O)CC4)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10767,ML00006090,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC/C=C3\CC(c4cc(CO)cc(NCC(C)O)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5CC)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10768,ML00005020,,,Cc1c2oc3c(C)c4oc(-c5ccccc5)nc4c(C(=O)N[C@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)cc1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10769,ML00000326,CHEMBL2371448,,Cc1c2oc3c(C)c4oc(CC(=O)NCCCCN)nc4c(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10770,ML00002946,,,O=C1CC2C#CC(c3cccc(CO)c3)C/C3=C/CCc4cccc(c4)CC4C(=O)CCC5C4CCCC5(O)C(Cc4cc2c(cc4O)O1)OC3=O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10771,ML00009046,,,C=C1C[C@H](OC)CCCCC/C2=C\C(=O)O[C@H](/C=C(/C)CC(=O)O[C@@H](/C=C\CC)[C@@H](C)[C@H](O)C(=O)N2)C/C(C)=C\C=C/1C,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10772,ML00005341,,,Cc1c2oc3c(C)ccc(C(=O)NC4C(=O)NC(C(C)C)C(=O)N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)c3nc-2c(C(=O)NC2C(=O)NC(C(C)C)C(=O)N3CC(=O)CC3C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10773,ML00002231,,,CC1(O)C2CCC(=O)C(Cc3cccc(c3)CC/C=C3\CC(c4cccc(CO)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10774,ML00004939,,,Cc1c2oc3c(C)c(O)c(N)c(C(=O)N[C@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c/c1=N/Cc1ccccc1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10775,ML00005275,,,CCCC1(O)C2CCC(=O)C(Cc3ccc4c(c3)CC(O)/C(=C3\CC(c5cc(CO)cc(NCC(C)(O)CCOC)c5)C#CC5CC(=O)Oc6c5cc(c(O)c6C5CCCCC5)CC1OC3=O)CC4)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10776,ML00005014,,,Cc1nc2c(C(=O)N[C@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]3C)c3nc4c(C(=O)N[C@@H]5C(=O)N[C@H](C(C)C)C(=O)N6CCC[C@H]6C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]5C)cc(=O)c(C)c-4oc3c(C)c2o1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10777,ML00005031,,,CCCCCCOc1cc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2nc3c(C(=O)N[C@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]4C)c(N)c(=O)c(C)c-3oc2c1C,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10778,ML00000533,CHEMBL3220396,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N\OCOCCOC)[C@H](C)C[C@@]4(C)O)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/O)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10779,ML00000898,CHEMBL4094032,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)C[C@H](O)[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CC(=O)C[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C)C(=O)O[C@@H]2CCl)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10780,ML00004947,,,Cc1c2oc3c(C)c(NCc4ccc(Cl)c(Cl)c4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10781,ML00004924,,,Cc1c2oc3c(C)c(NCc4ccc(C(=O)O)cc4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10782,ML00005334,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(Cl)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10783,ML00002948,,,O=C1CC2C#CC(c3cc(O)cc(CO)c3)C/C3=C/C(O)Cc4cccc(c4)CC4C(=O)CCC5C4CCCC5(O)C(Cc4cc2c(cc4O)O1)OC3=O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10784,ML00005647,,,CC(O)C(O)Cc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/CCc4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10785,ML00004967,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(NCCNC2CC(C)(C)[N+]([O-])C(C)(C)C2)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10786,ML00005043,,,Cc1ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2c1Oc1c(c(C(=O)N[C@@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]3C)c3nc(CCC(=O)O)c(=O)oc3c1C)N2,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10787,ML00004919,,,Cc1c2oc3c(C)ccc(C(=O)NC4C(=O)NC(C(C)C)C(=O)N5CCCC5C(=O)N(C)CC(=O)N(C)C(Cc5ccc(O)cc5)C(=O)OC4C)c3nc-2c(C(=O)NC2C(=O)NC(C(C)C)C(=O)N3CCCC3C(=O)N(C)CC(=O)N(C)C(Cc3ccc(O)cc3)C(=O)OC2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10788,ML00004927,,,Cc1ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2c1Oc1c(c(C(=O)N[C@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]3C)c3nc(-c4ccccc4)c(=O)oc3c1C)N2,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10789,ML00004941,,,Cc1c2oc3c(C)c(NCc4ccccc4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10790,ML00004920,,,Cc1c2oc3c(C)ccc(C(=O)NC4C(=O)NC(Cc5ccc(O)cc5)C(=O)N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)c3nc-2c(C(=O)NC2C(=O)NC(Cc3ccc(O)cc3)C(=O)N3CCCC3C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10791,ML00005403,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)C[C@H](O)[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C)C(=O)O[C@@H]2CO)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10792,ML00000909,CHEMBL3220961,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(=O)N(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10793,ML00005274,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(CCCCC3)C(O)/C=C3\CC(c4cc(CO)cc(NCC(C)O)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5C4CCCCC4)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10794,ML00004980,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(=O)CN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10795,ML00004993,,,CCCNc1c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c2nc3c(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)ccc(C)c3oc-2c(C)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10796,ML00005278,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(NCC(C)(O)CCOC)cc(C(O)CNC)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5C4CCCCC4)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10797,ML00006370,,,C/C=C1\NC(=O)[C@H]2NC(=O)[C@H](NC(=O)C(C)C)CCCNC(=O)Nc3cc(O)c(O)cc3C[C@H](C(=O)N[C@@H](C(C)C)C(=O)O[C@H]2C)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@@H]2O)NC1=O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10798,ML00005513,,,CCCC1(O)C2CCC(=O)C(Cc3ccc4c(c3)CC(O)/C(=C3\CC(c5cc(O)cc(CO)c5)C#CC5CC(=O)Oc6cc(O)c(cc65)CC1OC3=O)CC4)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10799,ML00002230,,,CC1(O)C2CCC(=O)C(Cc3cccc(c3)CC/C=C3\CC(c4cc(O)cc(CO)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10800,ML00005338,,,Cc1c2oc3c(C)ccc(C(=O)NC4C(=O)NC(C(C)C)C(=O)N5CC(=O)CC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)c3nc-2c(C(=O)NC2C(=O)NC(C(C)C)C(=O)N3CC(=O)CC3C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10801,ML00000329,CHEMBL2371447,,Cc1c2oc3c(C)c(O)c(N)c(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10802,ML00005514,,,CCC1CCC2C3Cc4cccc(c4)CC(O)/C=C4\CC(c5cc(O)cc(CO)c5)C#CC5CC(=O)Oc6cc(O)c(cc65)CC(OC4=O)C1(O)C2CCC3=O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10803,ML00000908,CHEMBL3217815,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(=O)N(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10804,ML00000538,CHEMBL3222011,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N\O)[C@H](C)C[C@@]4(C)O)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/O)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10805,ML00006006,,,COC(=O)C[C@@H]1C(=O)CC[C@H](C)C(=O)O[C@H]2[C@@H](OC(C)=O)[C@]3(COC1=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(=O)[C@@H](C)[C@@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@@]3([C@H](OC(C)=O)[C@@H]24)[C@@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10806,ML00006311,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(CO)cc(NCC(C)O)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10807,ML00001514,CHEMBL2372231,,COc1ccc(C[C@H]2NC(=O)[C@@H](NC(=O)c3c4nc5c(C(=O)N[C@@H]6C(=O)N[C@H](Cc7ccc(OC)cc7)C(=O)N7CCC[C@H]7C(=O)N(C)CC(=O)N[C@@H](C(C)C)C(=O)O[C@@H]6C)ccc(C)c5oc-4c(C)c(=O)c3N)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)CN(C)C(=O)[C@@H]3CCCN3C2=O)cc1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10808,ML00006329,,,CC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C4\CCc5ccc(cc5CC4O)CC4CC(CCC4=O)C3(C)O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10809,ML00004960,,,Cc1c2oc3c(C)c(OC(=O)c4ccc5ccccc5c4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10810,ML00005112,,,CO[C@@H]1[C@@H](OC2OC(C)C(OC3CC(C)(O)C(OC(=O)CC(C)C)C(C)O3)C(N(C)C)C2O)[C@@H](CCNCC[C@@H]2C[C@H](C)[C@H](O)/C=C/C=C/C[C@H](C)OC(=O)C[C@H](OC(C)=O)[C@@H](OC)[C@@H]2OC2OC(C)C(OC3CC(C)(O)C(OC(=O)CC(C)C)C(C)O3)C(N(C)C)C2O)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10811,ML00004507,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(CCCC3)C(O)/C=C3\CC(c4cc(CO)cc(NCC(C)O)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5C4CCCCC4)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10812,ML00005042,,,Cc1c2oc3c(C)c(NCc4ccco4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10813,ML00000918,CHEMBL442301,,Cc1nc2c(C(=O)N[C@H]3C(=O)N[C@@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]3C)c3nc4c(C(=O)N[C@@H]5C(=O)N[C@H](C(C)C)C(=O)N6CCC[C@@H]6C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]5C)c(N)c(=O)c(C)c-4oc3c(C)c2o1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10814,ML00005298,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)NCC(=O)N[C@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10815,ML00004792,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(CO)cc(NCC(C)O)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5C4C=CC=CC4)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10816,ML00004984,,,Cc1c2oc3c(C)c(OCc4ccc(Cl)c(Cl)c4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10817,ML00005035,,,Cc1ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2c1Oc1c(c(C(=O)N[C@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]3C)c3nc(-c4c(F)c(F)c(F)c(F)c4F)oc3c1C)N2,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10818,ML00004990,,,C=CCOc1cc(C(=O)NC2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]2C)c2nc3c(C(=O)NC4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]4C)c(N)c(=O)c(C)c-3oc2c1C,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10819,ML00005316,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](OC(=O)CCCCC(=O)O[C@H]2[C@@H](C)CCC[C@H]3O[C@H]3C[C@@H](/C(C)=C/c3csc(C)n3)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@@H]2C)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10820,ML00004971,,,COc1ccc(CC2C(=O)OC(C)C(NC(=O)c3c4nc5c(C(=O)NC6C(=O)NC(C(C)C)C(=O)N7CCCC7C(=O)N(C)CC(=O)N(C)C(Cc7ccc(OC)cc7)C(=O)OC6C)ccc(C)c5oc-4c(C)c(=O)c3N)C(=O)NC(C(C)C)C(=O)N3CCCC3C(=O)N(C)CC(=O)N2C)cc1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10821,ML00002938,,,CCNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/CCc4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10822,ML00005067,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(=O)N(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10823,ML00000534,CHEMBL3222012,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N\O)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N/O)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10824,ML00005450,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(CO)cc(NCC(C)(O)CCOC5CCCCC5)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5C4CCCCC4)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10825,ML00006093,,,CCC1CCC2C3Cc4cccc(c4)CC/C=C4\CC(c5cc(CO)cc(NCC(C)O)c5)C#CC5CC(=O)Oc6cc(O)c(cc65)CC(OC4=O)C1(O)C2CCC3=O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10826,ML00000535,CHEMBL3222009,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10827,ML00004999,,,Cc1c2oc3c(C)c(OCC(C)N)cc(C(=O)NC4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)NC2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10828,ML00004684,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(CO)cc(NCC(C)(O)CCOC)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5CC)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10829,ML00004485,,,CCCCCc1c(CO)cc(C2C#CC3CC(=O)Oc4c3cc(c(O)c4CC)CC3OC(=O)/C(=C/C(O)Cc4cccc(c4)CC4CC(CCC4=O)C3(O)CCC)C2)cc1NCC(C)O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10830,ML00005271,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)[C@@H](O)[C@H](C)C[C@@]4(C)O)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10831,ML00004992,,,Cc1c2oc3c(C)c(OCC4CN4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10832,ML00002945,,,CC1(O)C2CCC(=O)C(Cc3ccc4c(c3)CC/C(=C3\CC(c5cc(O)cc(CO)c5)C#CC5CC(=O)Oc6cc(O)c(cc65)CC1OC3=O)CC4)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10833,ML00004768,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(NCC(C)O)cc(C(O)CNC)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5CC)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10834,ML00000531,CHEMBL3220667,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N\O)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10835,ML00004922,,,Cc1ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2c1Oc1c(c(C(=O)N[C@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]3C)c3nc(-c4cccc(Cl)c4)c(=O)oc3c1C)N2,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10836,ML00000523,CHEMBL3218171,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N\OCc5cc(OC)c(OC)c(OC)c5)[C@H](C)C[C@@]4(C)O)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/OCc2cc(OC)c(OC)c(OC)c2)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10837,ML00005034,,,Cc1c2oc3c(C)c4oc(-c5c(F)c(F)c(F)c(F)c5F)nc4c(C(=O)N[C@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)cc1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10838,ML00002942,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC/C=C3\CC(c4cccc(CO)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10839,ML00004769,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(C/C=C4\CC(c5cc(CO)cc(NCC(C)O)c5)C#CC5CC(=O)Oc6cc(O)c(cc65)CC1OC4=O)CCCC3)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10840,ML00005007,,,CCOc1cc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2nc3c(C(=O)N[C@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]4C)c(N)c(=O)c(C)c-3oc2c1C,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10841,ML00002941,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC/C=C3\CC(c4cc(O)cc(CO)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10842,ML00000869,CHEMBL4099462,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)CC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CC(=O)C[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10843,ML00000916,CHEMBL2372386,,Cc1c2oc3c(C)c(OC[C@H]4CO4)cc(C(=O)N[C@@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10844,ML00005445,,,Cc1c2oc3cccc(C(=O)NC4C(=O)NC(C(C)C)C(=O)N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)c3nc-2c(C(=O)NC2C(=O)NC(C(C)C)C(=O)N3C(=O)CCC3C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10845,ML00002940,,,CNCC(O)c1cc(O)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/C(O)Cc4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10846,ML00005443,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)C[C@H](O)[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C)C(=O)O[C@@H]2CCl)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10847,ML00006062,,,CC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C4\CCc5ccc(cc5CC4O)CC4C(=O)CCC5C4CCCC35O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10848,ML00004940,,,Cc1c2oc3c(C)c(NCc4ccccc4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10849,ML00005030,,,CCCCCCNc1c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c2nc3c(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)ccc(C)c3oc-2c(C)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10850,ML00004633,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(CO)cc(NCC(C)(O)CCOC)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5C4CCCCC4)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10851,ML00006004,,,COC(=O)C[C@@H]1C(=O)CCC(C)C(=O)O[C@H]2[C@@H](OC(C)=O)[C@]3(COC1=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(=O)C(C)C(C)c4ncccc4C(=O)OC[C@]4(C)O[C@@]3([C@H](OC(C)=O)[C@@H]24)[C@@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10852,ML00006330,,,CC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(C/C=C4\CC(c5cc(O)cc(CO)c5)C#CC5CC(=O)Oc6cc(O)c(cc65)CC1OC4=O)CCCCC3)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10853,ML00006323,,,CCCCCc1c(O)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/C(O)Cc4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)cc1CO,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10854,ML00004977,,,CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H](O)CNN2C(=O)[C@H](C(C)C)OC(=O)[C@@H](C(C)C)NC(=O)[C@H]2C[C@@]3(O)c4cc(-c5ccc6c(c5)[C@]5(O)C[C@@H]7C(=O)N[C@H](C(C)C)C(=O)O[C@@H](C(C)C)C(=O)N8NC[C@@H](O)C[C@@H]8C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]([C@H](C)O)C(=O)N7[C@@H]5N6)ccc4N[C@@H]3N2C(=O)[C@@H]([C@H](C)O)NC1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10855,ML00006089,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(NCC(C)O)cc(C(O)CNC)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10856,ML00004979,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(=O)N(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10857,ML00005442,,,Cc1ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2nc3c(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)cccc3nc12,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10858,ML00005347,,,Cc1c2oc3c(C)ccc(C(=O)N[C@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10859,ML00005117,,,O=C1O[C@H]2[C@@H]3COC(=O)c4cc5c(c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@@H]2[C@H](OC(=O)c2cc(O)c(O)c4c2[C@H]2C1=CC(=O)C(O)(O)[C@]2(O)O4)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O3)Oc1c(cc(O)c(O)c1O)C(=O)O[C@@H]1O[C@H](COC(=O)c2cc(O)c(O)c(O)c2)[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(O)c1O5,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10860,ML00004944,,,Cc1c2oc3c(C)c(O)c(N)c(C(=O)N4OC(=O)[C@H](C(C)C)N(C)C(=O)CCNC(=O)[C@@H]5CCCN5C(=O)[C@H](C(C)C)NC(=O)[C@@H]4[C@@H](C)O)c3nc-2c(C(=O)N2OC(=O)[C@H](C(C)C)N(C)C(=O)CCNC(=O)[C@@H]3CCCN3C(=O)[C@H](C(C)C)NC(=O)[C@@H]2[C@@H](C)O)c/c1=N/Cc1ccc(Cl)c(Cl)c1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10861,ML00000917,CHEMBL4073381,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)CC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3[C@@H](C)CC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10862,ML00005330,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](OC(=O)CCSSCCC(=O)O[C@H]2[C@@H](C)CCC[C@H]3O[C@H]3C[C@@H](/C(C)=C/c3csc(C)n3)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@@H]2C)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10863,ML00005047,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(NCCCCN)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10864,ML00006314,,,CNCC(O)c1cc(NCC(C)O)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/C(O)Cc4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10865,ML00004923,,,Cc1ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2c1Oc1c(c(C(=O)N[C@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]3C)c3nc(-c4ccccc4Cl)c(=O)oc3c1C)N2,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10866,ML00005046,,,Cc1c2oc3c(C)c(OCCNCCO)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10867,ML00004928,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(NC(=O)OCc2ccc([N+](=O)[O-])cc2)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10868,ML00006308,,,CNCC(O)c1cc(NCC(C)O)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/CCc4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10869,ML00006332,,,CC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(CCCCC3)C(O)/C=C3\CC(c4cc(O)cc(CO)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10870,ML00006184,,,CCCCCc1c(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/C(O)Cc4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)cc1NCC(C)O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10871,ML00005028,,,Cc1c2oc3c(C)c(NCc4ccccn4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10872,ML00005072,,,CCCC(=O)OC1C(C)OC(OC2C(C)OC(O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CCNCC[C@@H]3C[C@H](C)[C@H](O)/C=C/C=C/C[C@H](C)OC(=O)C[C@H](O)[C@@H](OC)[C@@H]3OC3OC(C)C(OC4CC(C)(O)C(OC(=O)CCC)C(C)O4)C(N(C)C)C3O)C(O)C2N(C)C)CC1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10873,ML00004989,,,Cc1ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2c1Oc1c(c(C(=O)N[C@@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]3C)c3nc(C)c(=O)oc3c1C)N2,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10874,ML00005100,,,CC[C@@H]1OC(=O)C[C@H](O)[C@@H](C)[C@H](OC2OC(C)C(OC3CC(C)(O)C(O)C(C)O3)C(N(C)C)C2O)[C@H](CCNCC[C@H]2C[C@@H](C)[C@@H](O)/C=C/C(C)=C/C(COC3OC(C)C(O)C(OC)C3OC)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]2OC2OC(C)C(OC3CC(C)(O)C(O)C(C)O3)C(N(C)C)C2O)C[C@H](C)[C@H](O)/C=C/C(C)=C/C1COC1OC(C)C(O)C(OC)C1OC,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10875,ML00000188,CHEMBL2436596,,CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2coc(n2)CNC(=O)C[C@@H](/C=C/CCSSCC/C=C/[C@@H]2CC(=O)NCc3nc(co3)C3=N[C@@](C)(CS3)C(=O)N[C@@H](C(C)C)C(=O)O2)OC1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10876,ML00004926,,,Cc1ccc(C(=O)NC2C(=O)NC(C(C)C)C(=O)N3CCCC3C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC2C)c2c1Oc1c(c(C(=O)NC3C(=O)NC(C(C)C)C(=O)N4CCCC4C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC3C)c3nc(-c4ccccc4)c(=O)oc3c1C)N2,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10877,ML00005010,,,Cc1nc2c(C(=O)N[C@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]3C)c3c(c(C)c2o1)Oc1c(C)ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c1N3,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10878,ML00005119,,,O=C1O[C@H]2[C@@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]2[C@H](OC(=O)c2cc(O)c(O)c4c2[C@H]2C1=CC(=O)C(O)(O)[C@@]2(O)O4)[C@H](OC(=O)c1cc(O)c(O)c(O)c1Oc1cc2c(c(O)c1O)-c1c(cc(O)c(O)c1O)C(=O)O[C@@H]1[C@H]4OC(=O)c5cc(O)c(O)c6c5[C@@H]5C(=CC(=O)C(O)(O)[C@@]5(O)O6)C(=O)O[C@@H]1[C@@H](COC2=O)O[C@H]4OC(=O)c1cc(O)c(O)c(O)c1)O3,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10879,ML00004931,,,Cc1ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2c1Oc1c(c(C(=O)N[C@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]3C)c3nc(-c4c(F)c(F)c(F)c(F)c4F)c(=O)oc3c1C)N2,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10880,ML00005399,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](OC(=O)CCCCCCCCC(=O)O[C@H]2[C@@H](C)CCC[C@H]3O[C@H]3C[C@@H](/C(C)=C/c3csc(C)n3)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@@H]2C)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10881,ML00006063,,,CC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/C(O)C4(CCCC4)c4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10882,ML00004942,,,Cc1c2oc3c(C)c(OCc4ccc([N+](=O)[O-])cc4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10883,ML00002947,,,CC1(O)C2CCC(=O)C(Cc3ccc4c(c3)CC/C(=C3\CC(c5cccc(CO)c5)C#CC5CC(=O)Oc6cc(O)c(cc65)CC1OC3=O)CC4)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10884,ML00000904,CHEMBL3218945,,C=CCO/N=C1\[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N\OCC=C)[C@H](C)C[C@@]4(C)O)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@H]1C,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10885,ML00004620,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(CO)cc(NCC(C)(O)CCOC)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5C4C=CC=CC4)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10886,ML00006187,,,COCCC(C)(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/C(O)Cc4cccc(c4)CC4C(=O)CCC5C4CCCC35O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10887,ML00004918,,,Cc1c2oc3c(C)ccc(C(=O)NC4C(=O)NC(Cc5ccccc5)C(=O)N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)c3nc-2c(C(=O)NC2C(=O)NC(Cc3ccccc3)C(=O)N3CCCC3C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10888,ML00005050,,,Cc1c2oc3c(C)c(OCCN4CC4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10889,ML00005032,,,CCCCCCCOc1cc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2nc3c(C(=O)N[C@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]4C)c(N)c(=O)c(C)c-3oc2c1C,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10890,ML00004948,,,Cc1c2oc3c(C)c(NCc4ccc(C(=O)O)cc4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10891,ML00005276,,,CCCC1(O)C2CCC(=O)C(Cc3ccc4c(c3)CC(O)/C(=C3\CC(c5cc(CO)cc(NCC(C)(O)C(O)COC)c5)C#CC5CC(=O)Oc6c5cc(c(O)c6C5CCCCC5)CC1OC3=O)CC4)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10892,ML00005409,,,Cc1c2oc3c(C)ccc(C(=O)NC4C(=O)NC(C(C)O)C(=O)N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)c3nc-2c(C(=O)NC2C(=O)NC(C(C)O)C(=O)N3CCCC3C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10893,ML00006190,,,CCC1CCC2C3Cc4cccc(c4)C4(CCCC4)C(O)/C=C4\CC(c5cc(O)cc(CO)c5)C#CC5CC(=O)Oc6cc(O)c(cc65)CC(OC4=O)C1(O)C2CCC3=O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10894,ML00002937,,,CNCC(O)c1cccc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/CCc4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10895,ML00005340,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)C[C@H](O)[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3[C@@H](C)C(=O)C[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C)C(=O)O[C@H]2CCl)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10896,ML00004632,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(CO)cc(NCC(C)(O)C(O)COC)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5C4CCCCC4)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10897,ML00006092,,,CCCCCc1c(O)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/C(O)Cc4cccc(c4)CC4CC(CCC4=O)C3(O)CCC)C2)cc1CO,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10898,ML00004994,,,Cc1ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2c1Oc1c(c(C(=O)N[C@@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]3C)c3nc(CC(=O)O)c(=O)oc3c1C)N2,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10899,ML00000526,CHEMBL3220395,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/OCc2cc(OC)c(OC)c(OC)c2)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10900,ML00000914,CHEMBL2369548,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](Cc5ccc(O)cc5)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](Cc3ccc(O)cc3)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10901,ML00000903,CHEMBL3218944,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N\OCOCCOC)[C@H](C)C[C@@]4(C)O)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10902,ML00005012,,,Cc1c2oc3c(C)ccc(C(=O)N[C@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(CCC(=O)O)CC(=O)N[C@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@@H]3C(=O)N(CCC(=O)O)CC(=O)N[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10903,ML00004970,,,COc1ccc(CC2NC(=O)C(NC(=O)c3c4nc5c(C(=O)NC6C(=O)NC(Cc7ccc(OC)cc7)C(=O)N7CCCC7C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC6C)ccc(C)c5oc-4c(C)c(=O)c3N)C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C3CCCN3C2=O)cc1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10904,ML00005277,,,CCCCCc1c(CO)cc(C2C#CC3CC(=O)Oc4c3cc(c(O)c4C3CCCCC3)CC3OC(=O)/C(=C/C(O)Cc4cccc(c4)CC4CC(CCC4=O)C3(O)CCC)C2)cc1NCC(C)O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10905,ML00004946,,,Cc1c2oc3c(C)c(NCc4ccc(Cl)c(Cl)c4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10906,ML00005048,,,CCCCOc1cc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2nc3c(C(=O)N[C@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]4C)c(N)c(=O)c(C)c-3oc2c1C,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10907,ML00001509,CHEMBL2372236,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](Cc5ccccc5)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](Cc3ccccc3)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10908,ML00004759,,,CCC1CCC2C3Cc4cccc(c4)C4(CCCCC4)C(O)/C=C4\CC(c5cc(O)cc(CO)c5)C#CC5CC(=O)Oc6cc(O)c(cc65)CC(OC4=O)C1(O)C2CCC3=O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10909,ML00005375,,,CCC(C)C1NC(=O)C(NC(=O)c2c3nc4c(C(=O)NC5C(=O)NC(C(C)C)C(=O)N6CCCC6C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC5C)ccc(C)c4oc-3c(C)c(=O)c2N)C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10910,ML00005022,,,CCCCCNc1c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c2nc3c(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)ccc(C)c3oc-2c(C)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10911,ML00004938,,,CCCCCCCCNc1cc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2nc3c(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c(N)c(=O)c(C)c-3oc2c1C,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10912,ML00000922,CHEMBL385161,,Cc1c2oc3c(C)c(O)c(N)c(C(=O)N[C@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)cc1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10913,ML00004680,,,CCCCCc1c(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/C(O)Cc4cccc(c4)CC4C(=O)CCC5C4CCCC35O)C2)cc1NCC(C)O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10914,ML00005410,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](OC(=O)CCCCCCC(=O)O[C@H]2[C@@H](C)CCC[C@H]3O[C@H]3C[C@@H](/C(C)=C/c3csc(C)n3)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@@H]2C)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10915,ML00004959,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(NC2CC(C)(C)[N+]([O-])C(C)(C)C2)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10916,ML00000900,CHEMBL3221540,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]4(C)O)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10917,ML00006500,,,CCc1c(O)c2cc3c1OC(=O)CC3C#CC(c1cc(O)cc(CO)c1)C/C1=C/C(O)Cc3cccc(c3)CC3C(=O)CCC4C3CCC(CC)C4(O)C(C2)OC1=O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10918,ML00004968,,,Cc1c2oc3c(C)c(OC(=O)C45CC6CC(CC(C6)C4)C5)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10919,ML00005378,,,COc1cc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2nc3c(C(=O)N[C@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]4C)c(N)c(=O)c(C)c-3oc2c1C,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10920,ML00000004,CHEMBL1554,DACTINOMYCIN,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10921,ML00006096,,,CCc1c(O)c2cc3c1OC(=O)CC3C#CC(c1cc(CO)cc(NCC(C)O)c1)C/C1=C/C(O)Cc3cccc(c3)CC3C(=O)CCC4C3CCCC4(O)C(C2)OC1=O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10922,ML00006026,,,CC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/CCc4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10923,ML00006185,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC/C=C3\CC(c4cc(CO)cc(NCC(C)(O)CCOC)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10924,ML00004772,,,CCCCCc1c(O)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/C(O)Cc4cccc(c4)CC4C(=O)CCC5C4CCC(CC)C35O)C2)cc1CO,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10925,ML00005041,,,Cc1c2oc3c(C)c(NCc4ccco4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10926,ML00006038,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(CCCCC3)C(O)/C=C3\CC(c4cc(O)cc(CO)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10927,ML00005161,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(=O)CN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10928,ML00004782,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(CCCC3)C(O)/C=C3\CC(c4cc(CO)cc(NCC(C)O)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5CC)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10929,ML00005013,,,Cc1ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2c1Oc1c(c(C(=O)N[C@@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]3C)c3ncc(=O)oc3c1C)N2,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10930,ML00004770,,,CCCC1(O)C2CCC(=O)C(Cc3ccc4c(c3)CC(O)/C(=C3\CC(c5cc(CO)cc(NCC(C)O)c5)C#CC5CC(=O)Oc6c5cc(c(O)c6CC)CC1OC3=O)CC4)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10931,ML00000915,CHEMBL267466,,Cc1c2oc3c(C)c4oc(-c5ccccc5)nc4c(C(=O)N[C@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)NCC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@@H]3C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)O[C@@H]2C)cc1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10932,ML00005376,,,CC[C@H](C)[C@@H]1NC(=O)[C@@H](NC(=O)c2c3nc4c(C(=O)N[C@@H]5C(=O)N[C@H](C(C)C)C(=O)N6CCC[C@H]6C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]5C)ccc(C)c4oc-3c(C)c(=O)c2N)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10933,ML00002232,,,CC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(O)cc(CO)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10934,ML00004982,,,CCCCCCCCCNc1c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c2nc3c(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)ccc(C)c3oc-2c(C)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10935,ML00001504,CHEMBL413035,,CCC(C)C1NC(=O)C(NC(=O)c2c3nc4c(C(=O)NC5C(=O)NC(C(C)CC)C(=O)N6CCCC6C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC5C)ccc(C)c4oc-3c(C)c(=O)c2N)C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10936,ML00005346,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(O)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10937,ML00005515,,,CC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(C/C=C4\CC(c5cccc(CO)c5)C#CC5CC(=O)Oc6cc(O)c(cc65)CC1OC4=O)CCCC3)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10938,ML00000524,CHEMBL3218170,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N\OCc5ccccc5)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N/OCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10939,ML00006834,,,CC1CCCCCC(O)C(=O)C(SC2CC(=O)OC(C)CCCCCC(O)C2=O)CC(=O)O1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10940,ML00005051,,,Cc1c2oc3c(C)c(OCC4CC4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10941,ML00006095,,,CC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/CC4(CCCC4)c4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10942,ML00000902,CHEMBL3218946,,CCCCCO/N=C1\[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N\OCCCCC)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(OC)C[C@H]1C,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10943,ML00006328,,,CC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/C(O)Cc4cccc(c4)CC4C(=O)CCC5C4CCCC35O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10944,ML00005339,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)CC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3[C@@H](C)C(=O)C[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C)C(=O)O[C@H]2CCl)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10945,ML00005342,,,Cc1c2oc3c(C)ccc(C(=O)NC4C(=O)NC(C(C)C)C(=O)N5CC(O)CC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)c3nc-2c(C(=O)NC2C(=O)NC(C(C)C)C(=O)N3CC(O)CC3C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10946,ML00000327,CHEMBL2371444,,Cc1c2oc3c(C)c4oc(-c5ccccc5)nc4c(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10947,ML00004937,,,CCCCCCCCNc1cc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2nc3c(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c(N)c(=O)c(C)c-3oc2c1C,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10948,ML00000911,CHEMBL3222010,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)[C@@H](O)[C@H](C)C[C@@]4(C)O)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10949,ML00005348,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10950,ML00004997,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(NCCCN)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10951,ML00005377,,,Cc1c2oc3c(C)c(O)c(N)c(C(=O)N4OC(=O)[C@H](C(C)C)N(C)C(=O)CCNC(=O)[C@@H]5CCCN5C(=O)[C@H](C(C)C)NC(=O)[C@@H]4[C@@H](C)O)c3nc-2c(C(=O)N2OC(=O)[C@H](C(C)C)N(C)C(=O)CCNC(=O)[C@@H]3CCCN3C(=O)[C@H](C(C)C)NC(=O)[C@@H]2[C@@H](C)O)cc1=N,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10952,ML00006012,,,CC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/C(O)Cc4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10953,ML00005369,,,CC[C@H](C)[C@H]1NC(=O)[C@@H](NC(=O)c2c3nc4c(C(=O)N[C@@H]5C(=O)N[C@@H](C(C)C)C(=O)N6CCC[C@@H]6C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]5C)ccc(C)c4oc-3c(C)c(=O)c2N)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10954,ML00004961,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(NCCCNC2CC(C)(C)[N+]([O-])C(C)(C)C2)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10955,ML00002853,,,COC(=O)C[C@@H]1C(=O)CC[C@H](C)C(=O)O[C@H]2[C@@H](OC(C)=O)[C@]3(COC1=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(=O)[C@H](O)[C@H](C)c4ccncc4C(=O)OC[C@]4(C)O[C@@]3([C@H](OC(C)=O)[C@@H]24)[C@@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10956,ML00005174,,,Cc1c2oc3c(C)c(NCc4cccc(Oc5ccccc5)c4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10957,ML00004950,,,Cc1ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2c1Oc1c(c(C(=O)N[C@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]3C)c3nc(-c4ccccc4)oc3c1C)N2,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10958,ML00006310,,,CCCCCc1c(O)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/CCc4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)cc1CO,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10959,ML00004943,,,Cc1c2oc3c(C)c(OCc4ccc(Cl)cc4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10960,ML00006451,,,CCC1CCC2C3Cc4ccc5c(c4)CC(O)/C(=C4\CC(c6cc(O)cc(CO)c6)C#CC6CC(=O)Oc7cc(O)c(cc76)CC(OC4=O)C1(O)C2CCC3=O)CC5,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10961,ML00000518,CHEMBL427947,,Cc1c2oc3c(C)ccc(C(=O)NC4C(=O)NC(C(C)C)C(=O)N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)c3nc-2c(C(=O)NC2C(=O)NC(C(C)C)C(=O)N3CCCC3C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10962,ML00002943,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(O)cc(CO)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10963,ML00006091,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(CO)cc(NCC(C)O)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5CC)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10964,ML00002936,,,CNCC(O)c1cc(O)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/CCc4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10965,ML00001500,CHEMBL2159004,,Cc1c2oc3c(C)c(N)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10966,ML00000530,CHEMBL3221254,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N\O)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N/O)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10967,ML00004991,,,Cc1c2oc3c(C)c(OCC4CO4)cc(C(=O)N[C@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10968,ML00000921,CHEMBL406071,,Cc1c2oc3c(C)c(O)c(N)c(C(=O)N[C@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10969,ML00006188,,,CC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/C(O)C4(CCCCC4)c4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10970,ML00005508,,,CC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(CCCC3)C(O)/C=C3\CC(c4cc(O)cc(CO)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10971,ML00005175,,,Cc1c2oc3c(C)c(NCc4cccc(Oc5ccccc5)c4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10972,ML00006073,,,CCCC1(O)C2CCC(=O)C(Cc3ccc4c(c3)CC(O)/C(=C3\CC(c5cc(CO)cc(NCC(C)O)c5)C#CC5CC(=O)Oc6cc(O)c(cc65)CC1OC3=O)CC4)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10973,ML00005345,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)cc1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10974,ML00005106,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N\OCc5ccccc5)[C@H](C)C[C@@]4(C)O)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/OCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10975,ML00005154,,,Cc1ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2c1Oc1c(c(C(=O)N[C@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]3C)c3nc(-c4ccc5ccccc5c4)c(=O)oc3c1C)N2,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10976,ML00006186,,,CC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/CC4(CCCCC4)c4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10977,ML00005404,,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](OC(=O)CCCSSCCCC(=O)O[C@H]2[C@@H](C)CCC[C@H]3O[C@H]3C[C@@H](/C(C)=C/c3csc(C)n3)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@@H]2C)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10978,ML00006498,,,COCCC(C)(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/C(O)Cc4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10979,ML00005052,,,COC(=O)CCN1CC(=O)N[C@H](C(C)C)C(=O)O[C@@H](C)[C@@H](NC(=O)c2c3nc4c(C(=O)N[C@@H]5C(=O)N[C@H]([C@H](C)O)C(=O)N6CCC[C@@H]6C(=O)N(CCC(=O)OC)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]5C)ccc(C)c4oc-3c(C)c(=O)c2N)C(=O)N(C)[C@@H]([C@@H](C)O)C(=O)N2CCC[C@H]2C1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10980,ML00004996,,,Cc1c2oc3c(C)c(OCC(O)CO)cc(C(=O)N[C@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10981,ML00001499,CHEMBL2369551,,CC[C@@H](C)[C@H]1NC(=O)[C@@H](NC(=O)c2c3nc4c(C(=O)N[C@@H]5C(=O)N[C@H]([C@H](C)CC)C(=O)N6CCC[C@H]6C(=O)N(C)CC(=O)N[C@@H](C(C)C)C(=O)O[C@@H]5C)ccc(C)c4oc-3c(C)c(=O)c2N)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)CN(C)C(=O)[C@@H]2CCCN2C1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10982,ML00005265,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(CCCCC3)C(O)/C=C3\CC(c4cc(CO)cc(NCC(C)O)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5C4C=CC=CC4)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10983,ML00005039,,,Cc1c2oc3c(C)c(O)c(N)c(C(=O)N[C@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c/c1=N/Cc1ccc[nH]1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10984,ML00005441,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)C[C@H](O)[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10985,ML00004916,,,Cc1ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2c1Oc1c(c(C(=O)N[C@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]3C)c3nc(-c4ccc(Cl)cc4)c(=O)oc3c1C)N2,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10986,ML00001511,CHEMBL2369547,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N[C@H](Cc5ccc(O)cc5)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N[C@H](Cc3ccc(O)cc3)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10987,ML00000101,CHEMBL3329621,,CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCSSCC/C=C/[C@@H]2CC(=O)NCc3nc(cs3)C3=N[C@@](C)(CS3)C(=O)N[C@@H](C(C)C)C(=O)O2)OC1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10988,ML00001507,CHEMBL2372240,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N[C@@H](Cc5ccccc5)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N[C@@H](Cc3ccccc3)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10989,ML00004486,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(CCCCC3)C(O)/C=C3\CC(c4cc(CO)cc(NCC(C)O)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5CC)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10990,ML00005095,,,CCCCCCCCO/N=C1\[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N\OCCCCCCCC)[C@H](C)C[C@@]4(C)O)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@H]1C,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10991,ML00000913,CHEMBL4098358,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)C[C@H](O)[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CC(=O)C[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C)C(=O)O[C@@H]2CO)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10992,ML00005446,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)C[C@H](O)[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c2c(c1=O)OC[C@H]1OC(=O)[C@H](C)N(C)C(=O)CN(C)C(=O)[C@@H]3CCCN3C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC2=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10993,ML00004683,,,CCCCCc1c(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/C(O)Cc4cccc(c4)CC4CC(CCC4=O)C3(O)CCC)C2)cc1NCC(C)O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10994,ML00001510,CHEMBL2369549,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N[C@@H](Cc5ccc(O)cc5)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10995,ML00005448,,,Cc1nc2c(C(=O)N[C@H]3C(=O)N[C@@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)NCC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]3C)c3nc4c(C(=O)N[C@@H]5C(=O)N[C@H](C(C)C)C(=O)N6CCC[C@@H]6C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)O[C@@H]5C)cc(=O)c(C)c-4oc3c(C)c2o1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10996,ML00005367,,,Cc1c2oc3c(C)c(O)c(N)c(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]2C)cc1=N,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10997,ML00000528,CHEMBL3217816,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(=O)N(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N/OCOCCOC)[C@H](C)C[C@@]4(C)O)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
10998,ML00004679,,,CC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/C(O)C4(CCCCC4)c4cccc(c4)CC4C(=O)CCC5C4CCCC35O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
10999,ML00005714,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(O)cc(CO)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5CC)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
11000,ML00005008,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11001,ML00006501,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(CCCC3)C(O)/C=C3\CC(c4cc(O)cc(CO)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
11002,ML00004949,,,CCCCCCc1nc2c(C(=O)N[C@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]3C)c3c(c(C)c2oc1=O)Oc1c(C)ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c1N3,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11003,ML00006331,,,CC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(C/C=C4\CC(c5cccc(CO)c5)C#CC5CC(=O)Oc6cc(O)c(cc65)CC1OC4=O)CCCCC3)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
11004,ML00005374,,,CO/N=C1/CC(C)N2C(=O)C(C(C)C)NC(=O)C(NC(=O)c3c4nc5c(C(=O)NC6C(=O)NC(C(C)C)C(=O)N7C(C)CC(O)C7C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC6C)ccc(C)c5oc-4c(C)c(=O)c3N)C(CO)OC(=O)C(C)N(C)C(=O)CN(C)C(=O)C12,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11005,ML00001512,CHEMBL2372239,,COc1ccc(C[C@@H]2NC(=O)CN(C)C(=O)[C@@H]3CCCN3C(=O)[C@@H](C(C)C)NC(=O)[C@@H](NC(=O)c3c4nc5c(C(=O)N[C@@H]6C(=O)N[C@H](C(C)C)C(=O)N7CCC[C@H]7C(=O)N(C)CC(=O)N[C@@H](Cc7ccc(OC)cc7)C(=O)O[C@@H]6C)ccc(C)c5oc-4c(C)c(=O)c3N)[C@@H](C)OC2=O)cc1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11006,ML00001508,CHEMBL2372234,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N[C@H](Cc5ccccc5)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N[C@H](Cc3ccccc3)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11007,ML00005018,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N\OCOCCOC)[C@H](C)C[C@@]4(C)O)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11008,ML00005038,,,Cc1c2oc3c(C)c(NCc4ccc[nH]4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11009,ML00009909,,,C=C1C[C@H](OC)CCCCC/C2=C\C(=O)O[C@H](/C=C(/C)CC(=O)O[C@@H](/C=C\C(C)C)[C@@H](C)[C@H](O)C(=O)N2)C/C(C)=C\C=C/1C,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
11010,ML00005036,,,Cc1c2oc3c(C)c(O)c(N)c(C(=O)N4OC(=O)[C@H](C(C)C)N(C)C(=O)CCNC(=O)[C@@H]5CCCN5C(=O)[C@H](C(C)C)NC(=O)[C@@H]4[C@@H](C)O)c3nc-2c(C(=O)N2OC(=O)[C@H](C(C)C)N(C)C(=O)CCNC(=O)[C@@H]3CCCN3C(=O)[C@H](C(C)C)NC(=O)[C@@H]2[C@@H](C)O)c/c1=N/Cc1ccc[nH]1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11011,ML00005011,,,Cc1nc2c(C(=O)N[C@@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]3C)c3nc4c(C(=O)N[C@@H]5C(=O)N[C@H](C(C)C)C(=O)N6CCC[C@H]6C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]5C)c(N)c(=O)c(C)c-4oc3c(C)c2o1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11012,ML00001525,CHEMBL2372235,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N[C@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N[C@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11013,ML00001506,CHEMBL3221253,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11014,ML00005344,,,Cc1c2oc3c(C)cc(F)c(C(=O)NC4C(=O)NC(C(C)C)C(=O)N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)c3nc-2c(C(=O)NC2C(=O)NC(C(C)C)C(=O)N3CCCC3C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11015,ML00005405,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(CO)cc(NCC(C)(O)C(O)COC5CCCC5)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5C4CCCCC4)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
11016,ML00000537,CHEMBL3219219,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11017,ML00004995,,,CCCOc1cc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2nc3c(C(=O)N[C@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]4C)c(N)c(=O)c(C)c-3oc2c1C,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11018,ML00006005,,,COC(=O)C[C@@H]1C(=O)CC[C@H](C)C(=O)O[C@H]2[C@@H](OC(C)=O)[C@]3(COC1=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(=O)[C@H](C)[C@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@@]3([C@H](OC(C)=O)[C@@H]24)[C@@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11019,ML00005040,,,Cc1c2oc3c(C)c(O)c(N)c(C(=O)N[C@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c/c1=N/Cc1ccco1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11020,ML00006170,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(CO)cc(NCC(C)(O)CCOC)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
11021,ML00005420,,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11022,ML00006324,,,CC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/CCc4cccc(c4)CC4C(=O)CCC5C4CCCC35O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
11023,ML00004981,,,CCCCCCCCC/N=c1/cc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2nc3c(C(=O)N[C@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]4C)c(N)c(O)c(C)c3oc-2c1C,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11024,ML00004945,,,Cc1c2oc3c(C)c(O)c(N)c(C(=O)N[C@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c/c1=N/Cc1ccc(Cl)c(Cl)c1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11025,ML00004983,,,Cc1c2oc3c(C)c(OC(=O)c4ccccc4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11026,ML00004771,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(CCCC3)C(O)/C=C3\CC(c4cc(CO)cc(NCC(C)O)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
11027,ML00004673,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(CCCCC3)C(O)/C=C3\CC(c4cc(CO)cc(NCC(C)O)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
11028,ML00005173,,,Cc1c2oc3c(C)c(O)c(N)c(C(=O)N[C@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c/c1=N/Cc1cccc(Oc2ccccc2)c1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11029,ML00004936,,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(NCCCCCCCCN)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11030,ML00010595,,,C[C@@H]1CC[C@H]([C@H]2CCC[C@@H](C)OC(=O)Cc3cc(O)cc(O)c3C(=O)C2)/C=C\C(=O)c2c(O)cc(O)cc2CC(=O)O1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11031,ML00000536,CHEMBL3219220,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](N)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11032,ML00005037,,,Cc1c2oc3c(C)c(NCc4ccc[nH]4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11033,ML00002944,,,O=C1CC2C#CC(c3cc(O)cc(CO)c3)C/C3=C/CCc4cccc(c4)CC4C(=O)CCC5C4CCCC5(O)C(Cc4cc2c(cc4O)O1)OC3=O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
11034,ML00004917,,,Cc1c2oc3c(C)ccc(C(=O)NC4C(=O)NC(C(C)C)C(=O)N5CCCC5C(=O)N(C)CC(=O)N(C)C(Cc5ccccc5)C(=O)OC4C)c3nc-2c(C(=O)NC2C(=O)NC(C(C)C)C(=O)N3CCCC3C(=O)N(C)CC(=O)N(C)C(Cc3ccccc3)C(=O)OC2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
11035,ML00005517,,,CC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(C/C=C4\CC(c5cc(O)cc(CO)c5)C#CC5CC(=O)Oc6cc(O)c(cc65)CC1OC4=O)CCCC3)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
11036,ML00004781,,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(CO)cc(NCC(C)O)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5C4CCCCC4)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,