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macrolactone-toolkit/validation_output/summary.csv

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1idsource_idmolecule_namesmilesclassificationring_sizeprimary_reason_codeprimary_reason_messageprocessing_statuserror_messagenum_sidechainscleavage_positionsnumbered_image_pathprocessed_at
21CHEMBL1735765C[C@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
32nanO=C(C[C@@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@@H]2CCCN2C1=O)N[C@@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
43nanC/C=C1\C(OC2OC(CO)C(O)C(O)C2O)OC=C2C(=O)OCC(C)C3CC(OC(=O)CC21)C(C)C3COnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
54nanC[C@@H]1C[C@](O)([C@@H](C)Cl)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
65nanO=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(Oc4c(C(=O)OC[C@H]5O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]5O)cc(O)c(O)c4O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
76nanO=C1NC[C@H](c2ccccc2)OC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
87nanCO[C@H]1/C=C\CC/C=C\C(=O)O[C@@H](/C(C)=C/[C@H](C)C(=O)/C=C/CC2CC(=O)NC(=O)C2)[C@@H](C)[C@@H]1Ostandard_macrolactone12.0success4.0[3, 4, 5, 6]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.053274
98nanC[C@@H]1COC(=O)[C@@H](CC(=O)OC(C)(C)C)C/C=C\C[C@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
109nanCC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)CCCCCC/C=C/[C@H]1Cstandard_macrolactone12.0success2.0[3, 4]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.084453
1110nanCC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@](C)(O)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.122709
1211nanCC[C@]1(O)C[C@@H](C)[C@](C)(OC(C)=O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
1312nanCC1CCC(O)CCCCc2cc(O)cc(O)c2C(=O)O1standard_macrolactone12.0failednon-ring atom 0 marked aromaticring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.147647
1413nanCC(=O)O[C@H]1/C=C/C[C@@H](/C(C)=C/C=C/CC[C@H]2O[C@@H]2C[C@H](C)O)OC(=O)CCCC[C@@]1(C)Ostandard_macrolactone12.0success4.0[3, 7, 8, 8]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.183707
1514nanO=C1O[C@@H](c2ccccc2)C[C@@H](O)C(=O)CCCCc2ccccc21standard_macrolactone12.0failednon-ring atom 0 marked aromaticring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.204651
1615nanCO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H](CO)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cc(O)c(Br)cc1Brnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
1716nanO=C(Oc1c(O)cc2c(c1O)-c1c(cc(O)c(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](O)[C@H](OC2=O)[C@@H]1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
1817nanC/C(=C\[C@@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@H]1OC(=O)/C=C\CC/C=C\C=C/[C@@H]1Cstandard_macrolactone12.0success2.0[3, 4]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.245607
1918nanC=COCOc1cc(O)c2c(c1)CCCCCCC[C@@H](C)OC2=Ostandard_macrolactone12.0failednon-ring atom 5 marked aromaticring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.263591
2019nanC=C1NC(=O)[C@@H](CCCc2ccc(OC)cc2)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C)NC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
2120nanC/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC1=O)[C@@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
2221nanCC(=O)O[C@@]1(C)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC(=O)[C@@](O)([C@@H](C)O)C[C@H]1C)[C@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
2322nanO=C(O)C[C@@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1C(=O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
2423nanCC(=O)O[C@@H]1/C=C\C[C@H](/C(C)=C/C=C/[C@@H](C)O)OC(=O)C[C@H](O)CC[C@H]1Cstandard_macrolactone12.0success4.0[3, 7, 8, 11]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.323166
2524nanO=C1OC[C@@H]2O[C@@H](O)[C@H]3OC(=O)c4cc(O)c(O)c5c4[C@@H]4C(=CC(=O)[C@](O)(O5)C4(O)O)C(=O)O[C@H]2[C@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]2C1=CC(=O)[C@](OC(=O)c1cc(O)c(O)c(O)c1)(O3)C2(O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
2625nanCC/C=C\C=C/C(=O)N/C=C/C[C@@H]1C[C@H](O)[C@H](C)C/C=C\Cc2cccc(O)c2C(=O)O1standard_macrolactone12.0failednon-ring atom 0 marked aromaticring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.349246
2726CHEMBL2381165CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4ccc(I)c(O)c4)O[C@@]1(C3)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
2827nanO=C(C[C@@H]1C/C=C\C[C@H](Cc2ccc(F)cc2)C(=O)OCCNC1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
2928nanC[C@@H]1CCCCC[C@H](O)C(=O)[C@H](O)CC(=O)O1standard_macrolactone12.0success4.0[3, 9, 10, 11]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.392334
3029nanC=C1C/C(=C\C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@@]1(C)OC(C)=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
3130nanC[C@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
3231nanCC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](OC(C)=O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.442180
3332nanC[C@@H]1CCC[C@@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0failednon-ring atom 0 marked aromaticring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.460231
3433nanO=C(C[C@@H]1C/C=C\CCC(=O)OC[C@H](Cc2ccccc2)NC1=O)N[C@@H](CO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
3534nanC/C=C1\C[C@H](C)[C@](C)(O)C(=O)OCC2=CCN3C[C@@H](O)[C@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
3635nanC[C@H]1CCC(=O)[C@@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0failednon-ring atom 0 marked aromaticring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.490508
3736CHEMBL524666O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]2C1=CC(=O)C(O)(O)C2(O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
3837nanC/C=C1\C(=O)O[C@@H]2CCN3CC[C@H](COC(=O)[C@@](C)(O)[C@H](C)[C@@H]1O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
3938nanCOC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OC[C@H](NC(=O)[C@@H]2CCCN2C(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
4039nanCC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)[C@H](C)[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@H]1Cstandard_macrolactone12.0success7.0[3, 4, 7, 8, 8, 11, 12]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.553014
4140nanO=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@@H](O3)[C@@H](OC(=O)c3cc(O)c(O)c4c3[C@H]3C1=CC(=O)C(O)(O)[C@@]3(O)O4)[C@@H]2OC(=O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
4241CHEMBL1730563O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
4342nanC/C=C1\C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
4443nanCC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CCC[C@@H](O)/C=C\[C@@H]1Cstandard_macrolactone12.0success4.0[3, 4, 7, 11]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.604710
4544nanCC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@H](OC(=O)[C@@]3(C[C@@H]1C)O[C@@H]3C)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
4645nanCC[C@H]1C(=O)O[C@H]2CCNC/C=C(/COC(=O)[C@@](C)(O)[C@H](C)[C@@H]1O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
4746nanCC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)NC[C@@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
4847nanCC[C@H](O)C[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.667437
4948nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)Ostandard_macrolactone12.0success8.0[3, 4, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.712613
5049nanCC[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1standard_macrolactone12.0success6.0[3, 7, 8, 9, 10, 11]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.756811
5150nanO=C(O)C[C@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2c(cc(O)c(O)c2O)[C@H]1[C@H](O)C(=O)Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
5251CHEMBL39858CCCCCCC[C@H]1OC(=O)C[C@@H](OCOC)[C@H](Cc2ccccc2)N(C)C(=O)COC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
5352CHEMBL1879879C[C@@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
5453CHEMBL39969CCCCCCC[C@H]1OC(=O)C[C@@H](OCOC)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C)OC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
5554nanCC(=C/C(C)=C/C[C@@H](O)C[C@H](C)O)/C=C(C)\C=C\C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1Cstandard_macrolactone12.0success4.0[3, 6, 8, 9]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.817790
5655nanCC/C=C\C=C/CC[C@]1(C)C[C@H](O)[C@H](C)CC[C@H]2C[C@@H](C[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]3OC)C[C@@](O)(CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
5756CHEMBL35924CCCCCCC[C@@H]1CC(=O)O[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)[C@H](O)CC(=O)O1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
5857nanCO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](C(C)C)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success6.0[3, 7, 8, 9, 10, 11]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.874630
5958nanC[C@@H]1C[C@](O)([C@@H](C)Cl)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
6059nanC/C=C1/CC[C@@](C)(OC(C)=O)C(=O)OC[C@@]2(O)CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
6160nanCOC(=O)[C@H]1OC(=O)c2cc(O)c(O)c(O)c2[C@@H]1[C@H](CC(=O)O)C(=O)O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@@H](O)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
6261nanO=C(Oc1c(O)cc(C(=O)O[C@@H]2O[C@@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]([C@H]2O)[C@@H]3O)cc1O)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
6362nanC/C=C1/C[C@]2(CO2)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
6463CHEMBL1714949CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
6564nanCCOc1cc(O)c2c(c1)CCCCCCC[C@@H](C)OC2=Ostandard_macrolactone12.0failednon-ring atom 3 marked aromaticring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.937596
6665CHEMBL3260944CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)/C(C)=C\CCc3coc(/C=C\CNC(=O)OC)n3)C[C@H](CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
6766nanCO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@@]3(O)CC(=O)O[C@](C)(CC/C=C/C=C/Br)C[C@@H](O)[C@H](C)CC[C@H](O3)[C@@H]2C)[C@H](O)[C@@H]1OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
6867nanCO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](C)(O)[C@H]3O[C@@H]3O[C@@H](C)[C@H](O)[C@@](C)(O)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
6968nanC=CCOc1cc(O)c2c(c1)CCCCCCC[C@@H](C)OC2=Ostandard_macrolactone12.0failednon-ring atom 4 marked aromaticring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:31.975893
7069nanCO[C@H]1CC(=O)C/C=C\[C@@H](O)CC(=O)O[C@H](C)C1standard_macrolactone12.0success4.0[3, 5, 7, 11]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:32.022132
7170nanC/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
7271nanCC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:32.066182
7372nanC=C[C@H]1[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OCC[C@@H]3C(=CO[C@@H](O[C@H]4O[C@@H](CO)[C@H](OC(=O)/C=C/c5ccc(O)cc5)[C@@H](O)[C@@H]4O)[C@@H]3C=C)C(=O)OCC[C@H]21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
7473nanC[C@H]1C[C@H](C)[C@H](O)[C@H](C)C(=O)O[C@H]([C@H](C)O)[C@@H](C)/C=C\C1=Ostandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:32.113175
7574nanCO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3O[C@@](O)(C2)[C@H](C)C(=O)O[C@@H](/C=C/C=C/Br)C/C(C)=C\C(=O)C3(C)C)[C@H](OC)[C@@H]1O[C@@H]1O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]1OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
7675nanCO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@@H]3CC[C@@H](C)[C@H](O)C[C@@](C)(/C=C/C=C\Br)OC(=O)C[C@](O)(C2)O3)[C@H](OC)[C@@H]1OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
7776CHEMBL3260943CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)CCCCc3coc(CCCNC(=O)OC)n3)C[C@H](CC(=O)O1)O2non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
7877nanC/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
7978nanCO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@H]3[C@@H]4C=C5C(=O)[C@H](C)[C@@H](O)CCC[C@H](/C=C/[C@H](C)O)OC(=O)C[C@H]5[C@@H]4C=C[C@@H]3[C@@H]2O)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success6.0[3, 7, 8, 9, 10, 11]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:32.179547
8079nanO=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]3[C@H]1OC(=O)c1cc(O)c(O)c(O)c1[C@H]1C(=O)[C@H](O)C[C@@]1(O)C(=O)O[C@@H]32)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
8180nanCC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@@](O)([C@@H](C)Cl)C[C@H]1C)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
8281nanO=C1OC[C@@H]2O[C@H](OC(=O)c3cc(O)c(O)c(O)c3-c3c1cc(O)c(O)c3O)[C@H]1OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]1[C@H]2Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
8382nanC[C@H]1CCC(=O)[C@@H]2CC(=O)c3c(cc(O)cc3O2)CC(=O)O1non_standard_macrocycle12.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
8483nanC=C1C(=O)O[C@H]2CC(=O)n3ccc(c32)COC(=O)[C@](C)(OC(C)=O)[C@@H](C)[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
8584nanCC(=O)C[C@]1(O)C(=O)C=C2C(=O)O[C@H]3[C@@H]4OC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)OC[C@H]3O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]4OC(=O)c3cc(O)c(O)c4c3[C@H]2[C@@]1(O)O4non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
8685nanCCCCC[C@@H]1OC(=O)c2cc(ccc2C)Oc2ccc(O)c(C=O)c2/C=C\[C@@H]1Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
8786nanCO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](C)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success6.0[3, 7, 8, 9, 10, 11]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:32.266083
8887CHEMBL1551810CC(C)(C)[C@@H]1COC(=O)[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
8988nanO=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9089nanCO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H](O[C@@H]4O[C@@H](C)[C@H](O)[C@@](C)(O)[C@H]4OC)[C@@](C)(O)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9190CHEMBL3215313C=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2C2C(O)(O3)C3(O)OC4(C(=O)OC5C(O)COC54O)C12CC3=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9291nanC[C@@H]1C(=O)OCC(=O)N(C)[C@@H](Cc2ccccc2)[C@@H](O)CC(=O)O[C@@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9392nanC=C[C@H]1[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OCC[C@@H]3C(=CO[C@@H](O[C@H]4O[C@@H](CO)[C@H](OC(=O)/C=C\c5ccc(O)cc5)[C@@H](O)[C@@H]4O)[C@@H]3C=C)C(=O)OCC[C@H]21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9493nanCOc1cc2cc(c1Cl)N1CC(=O)C(C)(O)C(=O)N(C)C(C)C(=O)O[C@@H](CC1=O)[C@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C/C=C(\C)C2OCnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9594nanCOC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OCC(NC(=O)[C@H]2C(O)CCN2C(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9695nanC/C=C1/C[C@@H](C)[C@@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9796nanC[C@@H]1C[C@@]2(C)CC(=O)O[C@@H]3CCN4CC[C@H](COC(=O)[C@]1(C)O2)[C@H]34non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9897CHEMBL1727544O=C(C[C@@H]1C/C=C\C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@@H](Cc2ccccc2)NC1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
9998nanCCC(=O)/C(C)=C/[C@H](O)C[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:32.371987
10099nanCC[C@H]1O[C@H]1C[C@](C)(O)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:32.409528
101100nanC=C[C@@H]1[C@@H]2[C@@H]3/C=C\CC(=O)O[C@@]45C[C@@H](C)[C@@]6(O)[C@@H](C=C(CO)C[C@]7(O)C(=O)C(C)=C[C@H]76)[C@@H]4[C@@]5(C)COC(=O)[C@H]3[C@@H](/C=C/C=C/C=C/C=C/CCC)[C@@H]21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
102101CHEMBL1079558O=C(C[C@H]1C/C=C/CCC(=O)O[C@@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
103102nanCCC(=O)O[C@H]1/C=C\[C@H](C)[C@H](/C(C)=C/C=C/[C@H](C)C[C@H]2O[C@@H]2[C@H](C)[C@@H](O)CC)OC(=O)C[C@H](O)CC[C@]1(C)Ostandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:32.465657
104103nanCC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)NC[C@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
105104nanC/C=C1/C[C@@H](C)[C@@H](O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
106105nanC[C@@H]1CCCCCCCc2cc(OC(=O)c3ccc(Br)cc3)cc(OC(=O)c3ccc(Br)cc3)c2C(=O)O1standard_macrolactone12.0failednon-ring atom 0 marked aromaticring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:32.498502
107106nanC/C=C1/C[C@H](C)[C@](C)(O)C(=O)OCC2=CCN3CC[C@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
108107CHEMBL3623739O=C(C#Cc1ccccc1)N/C=C/C[C@H]1C[C@@H](O)CC/C=C/Cc2cccc(O)c2C(=O)O1standard_macrolactone12.0failednon-ring atom 0 marked aromaticring_size_12/standard/numbered/CHEMBL3623739_numbered.png2026-03-19 02:40:32.525375
109108nanO=C1OCC(O)C(C2OC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)c4c3C(=O)OC2C4O)OC(=O)c2cc(O)c(O)c(O)c2-c2cc1c(O)c(O)c2Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
110109nanCC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
111110CHEMBL1669768Cc1ccc(S(=O)(=O)Oc2cc3c(c(OS(=O)(=O)c4ccc(C)cc4)c2)C(=O)O[C@H](C)CCCCCCC3)cc1standard_macrolactone12.0failednon-ring atom 9 marked aromaticring_size_12/standard/numbered/CHEMBL1669768_numbered.png2026-03-19 02:40:32.560378
112111nanO=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)CO[C@H]([C@H]1O)[C@@H]2OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
113112nanC/C=C1/C[C@@H](C)[C@](C)(O)C(=O)OC[C@H]2CCN3CC[C@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
114113CHEMBL1710965O=C(N[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)OC1=O)OCC1c2ccccc2-c2ccccc21non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
115114nanCC/C=C\C=C/C(=O)N/C=C\C[C@H]1C[C@@H](O)[C@@H](C)C/C=C/Cc2ccc(F)c(O)c2C(=O)O1standard_macrolactone12.0failednon-ring atom 0 marked aromaticring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:32.602819
116115nanCC(C)(C)[C@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
117116nanC[C@@H]1CCC[C@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1standard_macrolactone12.0failednon-ring atom 0 marked aromaticring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:32.631438
118117nanC[C@H]1C[C@@](O)([C@H](C)O)C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@@]1(C)O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
119118nanCC[C@H](O)[C@@H](C)[C@@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](O)/C=C\[C@@H]1Cstandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:32.679522
120119nanO=C(C[C@@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](Cc2c[nH]c3ccccc23)NC1=O)NCCOnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
121120nanC/C=C1\C(=O)OC2CCN3CCC(COC(=O)C(C)(O)C(C)C1O)C23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
122121nanC=C(C#N)CO[C@@H]1O[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]([C@@H]1O)[C@@H]2Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
123122nanCC(=O)O[C@H]1/C=C\[C@H](C)[C@@H](/C(C)=C/C=C/[C@H](C)C[C@@H](C)/C=C(\C)[C@H](O)[C@H](C)O)OC(=O)C[C@@H](O)CC[C@@]1(C)Ostandard_macrolactone12.0success6.0[3, 4, 7, 8, 8, 11]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:32.740763
124123nanCOc1cc2c(c(OC)c1)C(=O)O[C@H](C)CCCCCCC2standard_macrolactone12.0failednon-ring atom 2 marked aromaticring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:32.760483
125124nanCC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)N2CCC[C@@H]2COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
126125nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H]([N+](C)(C)[O-])[C@@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)Ostandard_macrolactone12.0success8.0[3, 4, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:32.815619
127126nanCC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](c2ccccc2)COC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
128127nanCCC[C@@H]1OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)C(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
129128CHEMBL1606783CC(=O)C[C@H](O)CC(=O)[C@H]1OC(=O)CCCCCCCc2ccccc21standard_macrolactone12.0failednon-ring atom 0 marked aromaticring_size_12/standard/numbered/CHEMBL1606783_numbered.png2026-03-19 02:40:32.846679
130129nanCC/C=C/[C@H]1CCC[C@H](O[C@H]2C[C@@H](OC)[C@H](OC)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)[C@@H](O)[C@H]4C=C[C@H]3[C@@H]2CC(=O)O1standard_macrolactone12.0success6.0[3, 7, 8, 9, 10, 11]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:32.892376
131130nanCC[C@H]1OC(=O)[C@@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@H](C)C(=O)/C=C\[C@@H]1Cstandard_macrolactone12.0success7.0[3, 4, 7, 8, 10, 11, 12]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:32.933748
132131nanO=C1C[C@]2(O)OC(=O)[C@H](OC1=O)[C@H]2c1c(C(=O)O[C@H]2[C@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@@H](O[C@@H]2OC(=O)c2cc(O)c(O)c(O)c2)[C@H]3O)cc(O)c(O)c1Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
133132nanO=C(O)C[C@@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]1[C@H](O)C(=O)O3non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
134133nanC/C=C1/C[C@@H](C)[C@@](O)(CO)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC1=O)[C@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
135134nanC/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
136135nanC/C=C1/C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC1=O)[C@@]23Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
137136nanCOc1cc(O)cc2c1C(=O)O[C@H](C)[C@@H](O)CCCCCC2standard_macrolactone12.0failednon-ring atom 2 marked aromaticring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:32.986647
138137nanC/C=C1/C[C@H](C)[C@@](C)(OC(C)=O)C(=O)OCc2ccn3c2[C@H](CC3=O)OC1=Onon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
139138nanCCC(=O)C[C@H](O)C/C=C(C)/C=C(C)/C=C(C)/C=C/C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1Cstandard_macrolactone12.0success4.0[3, 6, 8, 9]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:33.025130
140139nanC=C1C(=O)OCC2=CCN3CC[C@@H](OC(=O)[C@](C)(O)[C@]4(CO4)[C@H]1C)[C@@H]23non_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
141140CHEMBL8097CCCCCCC[C@H]1OC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C)OC(=O)[C@H]1Cnon_standard_macrocycle12.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
142141nanCO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](C6CC6)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OCstandard_macrolactone12.0success6.0[3, 7, 8, 9, 10, 11]ring_size_12/standard/numbered/nan_numbered.png2026-03-19 02:40:33.079019
143142nanO=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
144143nanCCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
145144CHEMBL1710668O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
146145nanC[C@H]1CCC/C=C/[C@@H]2C[C@H](OC(=O)CCCC(=O)NCCCCCCO)C[C@H]2[C@H](O)/C=C/C(=O)O1standard_macrolactone13.0success4.0[3, 9, 10, 11]ring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:33.126908
147146nanCO[C@@H]1[C@H](O[C@H]2[C@H](OC)CO[C@@H](O[C@H]3C[C@H]4CC(=O)[C@@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)[C@@H]2OC)O[C@@H](C)[C@@H](O)[C@@H]1OCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
148147nanCCCCC(C)CC1NC(=O)C(C)NC(=O)C(Cc2ccccc2)NC(=O)CC(C(C)C)OC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
149148nanC[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C\C[C@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
150149nanCCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)C(C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([N+](C)(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
151150nanC/C=C1\NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)N[C@H](C)C(C)=O)[C@@H](C)OC1=Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
152151nanCO[C@@H]1/C=C/C(=O)O[C@@H](C)CCC/C=C\[C@@H]2C[C@H](O)C[C@H]21standard_macrolactone13.0success4.0[3, 9, 10, 11]ring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:33.189318
153152nanC[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([Se]c2ccccc2)CC(=O)O1standard_macrolactone13.0success5.0[3, 9, 10, 11, 12]ring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:33.229387
154153nanO=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCCCO1standard_macrolactone13.0success3.0[9, 10, 11]ring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:33.260312
155154nanO=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
156155nanCCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc2ccccc2)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
157156nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
158157nanCOc1ccc(C[C@H]2NC(=O)[C@]34OC(=O)O/C=C\[C@](C)(O)C(=O)[C@H](C)C/C=C\[C@@H]3[C@@H](O)C(C)=C(C)[C@H]24)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
159158nanCC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
160159CHEMBL383015RADANAMYCINCOc1c(O)cc2c(O)c1CC(C)OC(=O)c1c(O)cc(O)c(Cl)c1CCC(=O)N2non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
161160nanCC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
162161nanC[C@H]1CCC/C=C\[C@@H]2CC(=O)C[C@H]2[C@H](O)/C=C\C(=O)O1standard_macrolactone13.0success4.0[3, 9, 10, 11]ring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:33.353492
163162nanCC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
164163nanC/C=C1\CC(c2cc(CO)cc(NCC(O)C3CCCCC3)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=Ostandard_macrolactone13.0failednon-ring atom 4 marked aromaticring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:33.386167
165164nanCCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
166165nanO=C1CCC/C=C\CCOC(=O)c2c(O)cc(O)c(Cl)c2C1standard_macrolactone13.0failednon-ring atom 0 marked aromaticring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:33.413691
167166nanO=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
168167CHEMBL1079179COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)/C=C\[C@H](C)[C@H](C)OC2=Ostandard_macrolactone13.0failednon-ring atom 2 marked aromaticring_size_13/standard/numbered/CHEMBL1079179_numbered.png2026-03-19 02:40:33.440899
169168nanCC(C)CCCCCCCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H]1COC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)[C@@H](C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
170169nanCOc1ccc(S[C@@H]2CC(=O)O[C@@H](C)CCC/C=C/[C@@H]3C[C@H](O)C[C@H]3[C@@H]2O)cc1standard_macrolactone13.0success5.0[3, 9, 10, 11, 12]ring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:33.487728
171170nanC/C1=C/C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@H](C)C1)[C@H]23non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
172171nanCCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H]([C@H](C)O)[C@@](C)(O)[C@H](O)[C@@H](C)C3=C(C)C[C@@]2(C)O3)[C@@H]1Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
173172nanC[C@@H]1C/C(CO)=C\CC(=O)O[C@H](C)C/C=C\C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
174173nanCC(=O)O[C@@H]1/C=C/C(=O)O[C@@H](C)CCC/C=C\[C@@H]2C[C@H](O)C[C@H]21standard_macrolactone13.0success4.0[3, 9, 10, 11]ring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:33.541516
175174nanCCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
176175nanC/C=C1\CC(c2cc(CO)cc(NCC(C)(O)CCOC)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=Ostandard_macrolactone13.0failednon-ring atom 4 marked aromaticring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:33.567109
177176nanCCCC[C@H](C)[C@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
178177nanCC(C)(C)[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
179178nanCOc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)/C=C\[C@H](C)[C@@H](C)OC2=Ostandard_macrolactone13.0failednon-ring atom 2 marked aromaticring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:33.600388
180179nanC/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCC3CCC4CC(=O)CC3C42)OC1=Ostandard_macrolactone13.0failednon-ring atom 4 marked aromaticring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:33.626020
181180nanCC(C)CCC[C@H]1CC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
182181nanC[C@H]1CCC/C=C\[C@@H]2C[C@@H](O)C[C@H]2[C@H](O)/C=C\C(=O)O1standard_macrolactone13.0success4.0[3, 9, 10, 11]ring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:33.668586
183182nanCCNCC/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=Ostandard_macrolactone13.0failednon-ring atom 4 marked aromaticring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:33.690633
184183nanCCCCCC(CC(=O)N1N=CCCC1C(=O)N[C@H]1COC(=O)[C@H]2CCCNN2C(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)NC1=O)C(=O)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
185184CHEMBL26966CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
186185nanCCCCCC[C@H](C)[C@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
187186nanCCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)C(C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([N+](C)(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
188187nanCC1CCCC=CC2CC(OC(=O)CN(C)C)CC2C(O)C=CC(=O)O1standard_macrolactone13.0success4.0[3, 9, 10, 11]ring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:33.754982
189188nanNc1ccc(CC[C@H]2CCC/C=C/[C@@H]3C[C@H](O)C[C@H]3[C@H](O)/C=C/C(=O)O2)cc1standard_macrolactone13.0success4.0[3, 9, 10, 11]ring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:33.787696
190189nanCCCCCC[C@@H](C)[C@@H]1OC(=O)[C@H](CO)NC(=O)[C@H](C(=O)c2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H]1Cnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
191190CHEMBL1087150O=C(C[C@H]1C/C=C/CCCC(=O)O[C@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
192191nanCC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC/N=C(\N(C)C)N2CCOCC2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
193192nanCC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
194193nanO=C1CCC/C=C/C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
195194nanCOc1ccc(C[C@H]2NC(=O)[C@]34OC(=O)O/C=C\[C@@](C)(O)C(=O)[C@@H](C)C/C=C\[C@H]3[C@H]3O[C@@]3(C)[C@@H](C)[C@H]24)cc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
196195nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@](C)(O)C[C@@H](C)C2=C(C)C(=O)[C@@]1(C)O2non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
197196nanC[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
198197nanO=C(C[C@H]1C/C=C/CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H](c2ccccc2)NC1=O)NCCOnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
199198nanC/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=Ostandard_macrolactone13.0failednon-ring atom 4 marked aromaticring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:33.872086
200199nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)C[C@H](C)[C@H](O2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
201200nanC/C1=C/C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@H](C)C1)[C@H]23non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
202201CHEMBL1987060CC1CCC/C=C/C2CC(O)CC2C(O)/C=C/C(=O)O1standard_macrolactone13.0success4.0[3, 9, 10, 11]ring_size_13/standard/numbered/CHEMBL1987060_numbered.png2026-03-19 02:40:33.917870
203202nanCC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CCnon_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
204203nanC/C=C1\CC(c2cc(CO)c(CCCCC)c(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=Ostandard_macrolactone13.0failednon-ring atom 4 marked aromaticring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:33.947731
205204nanCCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)O1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
206205nanCC(=O)C[C@H](O)CC(=O)[C@@H]1OC(=O)CCCCCCCCc2ccccc21standard_macrolactone13.0failednon-ring atom 0 marked aromaticring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:33.973884
207206nanCOC(=O)c1ccccc1S[C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1Ostandard_macrolactone13.0success5.0[3, 9, 10, 11, 12]ring_size_13/standard/numbered/nan_numbered.png2026-03-19 02:40:34.011665
208207nanC=C1/C=C\[C@@H]([C@H](C)C(=C)C)OC(=O)C[C@]2(O)O[C@@H](CC(=C)[C@H]2C)[C@@H]2O[C@H]2C1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
209208nanO=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1non_standard_macrocycle13.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
210209nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCc3ccccc3)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:34.086679
211210nanCC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC#Cc2cc(-c3ncccn3)no2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12Cstandard_macrolactone14.0success14.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:34.155661
212211nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\Oc3ccc(-n4cccn4)nc3)CO2)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:34.220547
213212CHEMBL3092224CC(=O)OCC1=C(C)C[C@H]([C@@H](C)[C@H]2CC[C@H]3[C@@H]4C[C@H]5O[C@]56[C@@H]5C=CC(=O)[C@]6(COC(=O)CC/C=C/CCC(=O)O5)[C@H]4CC[C@@]32C)OC1=Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
214213nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)[C@@H](N)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:34.291937
215214nanCCC(=O)O[C@H]1[C@@H](OC(C)=O)[C@]2(COC(C)=O)[C@@H](OC(=O)c3ccccc3)[C@@H](O)[C@@H]3OC(=O)[C@@H](C)[C@@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@]2([C@H](OC(=O)c2ccccc2)[C@@H]14)[C@@]3(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
216215nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCSc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:34.363164
217216CHEMBL1256555CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1Cstandard_macrolactone14.0success12.0[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL1256555_numbered.png2026-03-19 02:40:34.423149
218217nanCCCCCNC(=O)CCCCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OCstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:34.486850
219218nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C/C=C/Cn3cnc(-c4cccnc4)c3)C(=O)N[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:34.552989
220219nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:34.617837
221220nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCn1cnc(-c2cccnc2)c1standard_macrolactone14.0success12.0[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:34.682083
222221CHEMBL1078360COc1ccc(CO[C@@H]2/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c3cc(OC)cc(O)c3C(=O)O[C@H]2C)cc1standard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/CHEMBL1078360_numbered.png2026-03-19 02:40:34.702935
223222nanC=CCCC(=O)O[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:34.773410
224223CHEMBL1097413C[C@@H]1OC(=O)c2c(O)cc(NCc3ccccc3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1Cstandard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/CHEMBL1097413_numbered.png2026-03-19 02:40:34.793204
225224nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:34.859993
226225nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2ccccn2)[C@H](C)[C@H]2OC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:34.925811
227226nanCC[C@@H]1OC(=O)C[C@@H](O[C@H]2C[C@@](C)(O)[C@H](O)[C@@H](C)O2)[C@H](C)[C@H](O[C@@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@H]1Cstandard_macrolactone14.0success11.0[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:34.982921
228227CHEMBL1256546CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL1256546_numbered.png2026-03-19 02:40:35.046811
229228nanC[C@H]1CCCC(=O)CCC/C=C\c2cc(O)cc(O)c2C(=O)O1standard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:35.065403
230229nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cncc3ccccc23)[C@H](C)[C@@H]2OC(=O)O[C@@]21Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:35.129994
231230nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCc3ccnc4ccccc34)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:35.208905
232231nanCOc1cc(O)c2c(c1)/C=C/CCCC(=O)CCC[C@H](C)OC2=Ostandard_macrolactone14.0failednon-ring atom 2 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:35.227879
233232nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCCc3ccccc3)CO2)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:35.293262
234233nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@](C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
235234nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3cccnc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
236235CHEMBL1097699C[C@@H]1OC(=O)c2c(O)cc(NCCO)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1Cstandard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/CHEMBL1097699_numbered.png2026-03-19 02:40:35.327313
237236nanCO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3O[C@@](O)(C2)[C@H](C)C(=O)O[C@@H](/C=C/C=C/Br)C[C@@H](C)/C=C\C[C@H](O)[C@@H]3C)[C@H](OC)[C@@H]1OCnon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
238237CHEMBL1214761CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL1214761_numbered.png2026-03-19 02:40:35.398223
239238nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccco1)[C@@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
240239nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCC(=O)NC3CCCCC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:35.472089
241240nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:35.538594
242241nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1Cstandard_macrolactone14.0success12.0[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:35.593630
243242nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC/C=C/c2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2)[C@H](C)[C@H]2OC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:35.657430
244243nanC/C(=C/C=C\C[C@H](O)C[C@@H]1CCC[C@H]2O[C@@](O)(CC[C@@H]3CC[C@H](O3)C(=O)O1)[C@H](O)[C@@H](O)[C@@H]2C)C/C=C\C=C/CCOnon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
245244CHEMBL418067CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C3CCCCC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL418067_numbered.png2026-03-19 02:40:35.730020
246245nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]4(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
247246nanCC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(-c4csnn4)nc3)CO2)[C@]1(C)Ostandard_macrolactone14.0success14.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:35.804268
248247CHEMBL1097784C[C@@H]1OC(=O)c2c(O)cc(OCCn3ccnn3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1Cstandard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/CHEMBL1097784_numbered.png2026-03-19 02:40:35.823332
249248nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
250249nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OCCNCCCCNCc2ccc(Oc3ccccc3)cc2)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:35.894319
251250nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:35.959621
252251nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNCc2cccc([N+](=O)[O-])c2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:36.028068
253252nanCOc1ccc(C2CC(=O)Oc3cc4c(c(OC)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1OC(C)Cstandard_macrolactone14.0failednon-ring atom 12 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:36.047820
254253nanCC[C@H]1OC(=O)[C@H](C)C(=O)C[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)C[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12Cstandard_macrolactone14.0success11.0[3, 4, 4, 5, 7, 8, 10, 10, 11, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:36.106469
255254nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCCC2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:36.172522
256255nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccc([N+](=O)[O-])c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:36.237282
257256nanC=C1/C=C(\C)[C@H](CC)OC(=O)[C@@H](C)C(=O)[C@](C)(CO)C/C(OC)=C/[C@@H](C)C1standard_macrolactone14.0success9.0[3, 4, 6, 8, 10, 12, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:36.288148
258257CHEMBL12589CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCNC2=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL12589_numbered.png2026-03-19 02:40:36.359845
259258CHEMBL532ERYTHROMYCINCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL532_numbered.png2026-03-19 02:40:36.425161
260259CHEMBL313882C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)NC2CCCCC2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1standard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/CHEMBL313882_numbered.png2026-03-19 02:40:36.445554
261260CHEMBL3392931CC[C@@H]1OC(=O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@](C)(O)C[C@H](C)C(=O)[C@@H](C)[C@H](O)[C@@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL3392931_numbered.png2026-03-19 02:40:36.510991
262261nanCC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)N/C=C/c2ccc(-c3ccccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:36.577538
263262nanCCCCCCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)CCCCCCC)[C@@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OCstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:36.643489
264263nanCCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)C(N)C(C)C(OC(=O)O)C1(C)OC(=O)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:36.709010
265264nanCOc1cc(O)c2c(c1)/C=C/C[C@@H]1OC(C)(C)O[C@@H]1C(=O)/C=C\C[C@H](C)OC2=Ostandard_macrolactone14.0failednon-ring atom 2 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:36.729567
266265nanCOc1cc(O)c2c(c1)CCCC(O)C(O)C(=O)C=CCC(C)OC2=Ostandard_macrolactone14.0failednon-ring atom 2 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:36.749161
267266CHEMBL1669776CC(=O)Oc1cc2c(c(OC(C)=O)c1)C(=O)OCCCCCCCCCC2standard_macrolactone14.0failednon-ring atom 4 marked aromaticring_size_14/standard/numbered/CHEMBL1669776_numbered.png2026-03-19 02:40:36.768202
268267nanC=C[C@]12OC(=O)N(CCCCn3cc(Cl)c4ncccc43)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CCstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:36.838462
269268nanCCCCNC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:36.907387
270269nanCOC1C=CCCC=CC(=O)OC(C(C)C(=O)CCCC2CC(=O)NC(=O)C2)C(C)=CC(C)C1Ostandard_macrolactone14.0success5.0[3, 4, 6, 7, 8]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:36.942840
271270nanCC(=O)OCC12C(OC(C)=O)C(=O)C3C(O)C14OC3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)OC(C(OC(C)=O)C2OC(C)=O)C4(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
272271nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nc(-c4ccccc4)cs3)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:37.015232
273272nanC[C@H]1COC(=O)CC=C[C@@H](C)[C@@H]2C=C[C@H](O)[C@@H](COC1=O)O2non_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
274273nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)C(C)C)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/C=C/c2cccnc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:37.087017
275274CHEMBL3650149CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CN2CCOCC2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(=O)CN(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)C2N(CCCOc3cc(C(=O)Nc4c(Cl)cncc4Cl)ccc3OC)C(=O)O[C@@]21Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL3650149_numbered.png2026-03-19 02:40:37.157227
276275CHEMBL1651523COc1cc(O)c2c(c1)CCCCCC(=O)/C=C\C[C@H](C)OC2=Ostandard_macrolactone14.0failednon-ring atom 2 marked aromaticring_size_14/standard/numbered/CHEMBL1651523_numbered.png2026-03-19 02:40:37.176038
277276nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:37.243281
278277nanCC[C@H](C)[C@@]1(O)CC(=O)O[C@H](C)[C@@](O)(C(C)C)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23non_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
279278nanCOc1cc(O)c2c(c1Br)C(=O)OCC(=O)NCC(=S)N[C@H](c1nc(C)no1)CSC2non_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
280279nanCC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)/C(C)=C/[C@]1(C)Ostandard_macrolactone14.0success11.0[3, 4, 4, 6, 7, 8, 10, 10, 11, 12, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:37.312175
281280nanCOc1cc(O)c2c(c1Br)C(=O)OCCNCC(=O)N[C@H](c1nc(C)no1)CSC2non_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
282281nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(=O)[C@@H](C)[C@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@]1([C@H](OC(C)=O)[C@@H]4C(=O)[C@@H]2OC(C)=O)[C@@]3(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
283282nanCOc1cc(O)c(Cl)c2c1C(=O)OC(C)CCC(=O)CCC(OC)CC(=O)C2standard_macrolactone14.0failednon-ring atom 2 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:37.344747
284283nanCC(C)[C@@]1(O)C(=O)OCC2=CCN3CC[C@@H](OC(=O)[C@@](O)(C(C)C)[C@@H](O)C(=O)O[C@@H]1C)[C@@H]23non_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
285284nanCC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(N)=O)C[C@@H](C)/C(=N\O)[C@H](C)[C@H]2NC(=O)O[C@]12Cstandard_macrolactone14.0success14.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:37.418505
286285CHEMBL2375656COc1cc(O)c2c(c1)CC(=O)CCCC(=O)CCC[C@@H](C)OC2=Ostandard_macrolactone14.0failednon-ring atom 2 marked aromaticring_size_14/standard/numbered/CHEMBL2375656_numbered.png2026-03-19 02:40:37.438378
287286nanC[C@H]1C[C@H]2O[C@@H]2CC/C=C\C(=O)Cc2cc(O)cc(O)c2C(=O)O1standard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:37.458452
288287CHEMBL1256537CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL1256537_numbered.png2026-03-19 02:40:37.523218
289288nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:37.586570
290289CHEMBL1214762CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL1214762_numbered.png2026-03-19 02:40:37.649117
291290nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(O)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:37.712314
292291CHEMBL1668417COc1cc(O)c2c(c1)/C=C\CCCC(=O)C[C@H](Br)C[C@H](C)OC2=Ostandard_macrolactone14.0failednon-ring atom 2 marked aromaticring_size_14/standard/numbered/CHEMBL1668417_numbered.png2026-03-19 02:40:37.732631
293292nanCCCCCCCCCCCCC(=O)O[C@H]1[C@H](C)OC(O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc3ccccc3)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OCstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:37.803599
294293nanCOc1ccc(OC)c(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)c1standard_macrolactone14.0failednon-ring atom 15 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:37.824539
295294nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:37.891702
296295nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc3cccnc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2CC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:37.956244
297296nanCO[C@@]12CC[C@@H]3CC[C@H](O3)C(=O)O[C@H](C[C@@H](O)C/C=C\C=C(\C)C/C=C\C=C/CCO)CCC[C@@H](O1)[C@@H](C)[C@H](O)[C@H]2Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
298297nanC=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3cccnc3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4ccc5cccnc54)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:38.030082
299298nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc4ncccc43)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:38.096932
300299nanCCCNC(=O)CCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OCstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:38.160606
301300nanCC[C@H](C)[C@]1(O)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](O)(C(C)C)[C@@H](C)OC(=O)[C@@H]1O)[C@H]23non_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
302301nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2ccc(-c3ccccn3)s2)C[C@@H](C)/C(=N\OC)[C@H](C)[C@H]2NC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:38.239298
303302nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](O)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cc(-c4ccccn4)nn3)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:38.309954
304303nanC/C=C/C(=O)OC1C(OC(=O)c2ccc(=O)n(C)c2)C2OC(=O)C(C)C(C)c3ncccc3C(=O)OCC3(C)OC4(C(OC(C)=O)C3C(OC(C)=O)C(OC(C)=O)C14COC(C)=O)C2(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
305304nanO=C1CCCCCCCCCCCCO1standard_macrolactone14.0success0.0[]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:38.335906
306305CHEMBL1078777CC[C@H]1C/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(OC)cc(O)c2C(=O)O1standard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/CHEMBL1078777_numbered.png2026-03-19 02:40:38.355464
307306nanC=C1NC(=O)[C@@H](C)[C@@H](CC[C@@H](C)C(=O)/C=C/C(C)=C/C[C@@H](C)CCCCCCC)OC(=O)[C@H](C[C@@H](OS(=O)(=O)O)C(N)=O)NC(=O)[C@@H](C)CNC1=Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
308307nanC=CCO[C@@H]1C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)COc2ccccc2)[C@H](C)[C@H]1OC1O[C@H](C)C[C@H](N(C)C)[C@H]1Ostandard_macrolactone14.0success12.0[3, 4, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:38.424355
309308nanCOc1c2c(cc3c1C(c1cc4cc(C)ccc4n(CC(C)C)c1=O)CC(=O)O3)C=CCCCC(=O)CCCC(C)OC2=Ostandard_macrolactone14.0failednon-ring atom 2 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:38.444333
310309nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cccc3cccnc23)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:38.511028
311310nanC[C@@H]1OC(=O)c2c(O)cc(NOCC(=O)O)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1Cstandard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:38.530159
312311nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccccc3)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:38.594803
313312nanO=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]3[C@H](O)O[C@@H]2COC(=O)c2cc(O)c(O)c3oc(=O)c4cc(O)c(O)c(c4c23)Oc2c1cc(O)c(O)c2Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
314313CHEMBL2159138CC/N=C1\O[C@H]2[C@H](O[C@@H]3[C@@H](C)[C@H](O[C@H]4C[C@@](C)(OC)[C@@H](O)[C@H](C)O4)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]3(C)OC)O[C@H](C)C[C@@H]2N1Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL2159138_numbered.png2026-03-19 02:40:38.677283
315314CHEMBL1099011CCCOc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=Ostandard_macrolactone14.0failednon-ring atom 4 marked aromaticring_size_14/standard/numbered/CHEMBL1099011_numbered.png2026-03-19 02:40:38.697262
316315nanCOc1cc(O)c2c(c1Br)C(=O)OCCN(C(=O)[C@H](C)N)CC(=O)N[C@H](c1nc(C)no1)CSC2non_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
317316nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(-c5ccccc5)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:38.771340
318317nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NCC#Cc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:38.834263
319318nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2cnc3ccccc3c2)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:38.898243
320319nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)Ostandard_macrolactone14.0success10.0[3, 4, 4, 7, 8, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:38.949088
321320nanCOc1ccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)c(OC)c1OCstandard_macrolactone14.0failednon-ring atom 12 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:38.969336
322321CHEMBL1256547CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL1256547_numbered.png2026-03-19 02:40:39.044828
323322nanC=CCO[C@@H]1C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccc(Cl)cc2)[C@H](C)[C@H]1OC1O[C@H](C)C[C@H](N(C)C)[C@H]1Ostandard_macrolactone14.0success12.0[3, 4, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:39.113830
324323nanCOc1cc(O)c(Cl)c2c1C(=O)O[C@@H](C)CCC(=O)CC/C=C\C(=O)C2standard_macrolactone14.0failednon-ring atom 2 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:39.133220
325324nanCC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(C(N)=O)s3)CO2)[C@]1(C)Ostandard_macrolactone14.0success14.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:39.202537
326325nanCOc1cc(O)c2c(c1)/C=C\C[C@H](O)[C@@H](O)C(=O)CCC[C@H](C)OC2=Ostandard_macrolactone14.0failednon-ring atom 2 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:39.222801
327326CHEMBL276217CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@H]2CC(C)C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL276217_numbered.png2026-03-19 02:40:39.293670
328327CHEMBL584552CCNC(=O)CO[C@H]1[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL584552_numbered.png2026-03-19 02:40:39.359538
329328nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCc2cccs2)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:39.424699
330329nanCO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@]3(CO3)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]2C)O[C@@H](C)[C@@H]1Ostandard_macrolactone14.0success12.0[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:39.485735
331330nanCC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3cccc(C(N)=O)c3)CO2)[C@]1(C)Ostandard_macrolactone14.0success14.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:39.553385
332331CHEMBL416337CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCN(C)C2=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL416337_numbered.png2026-03-19 02:40:39.619554
333332nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:39.683636
334333nanCCOCCCNC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:39.748027
335334nanCCCC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:39.811652
336335nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
337336nanC=C1NC(=O)C(C)C(CCC(C)C(=O)C=CC(C)=CCC(C)CCCCCCC)OC(=O)[C@H](CC(OS(=O)(=O)O)C(N)=O)NC(=O)[C@@H](C)CNC1=Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
338337nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=N\OCc3cc(-c4cccc(C#N)n4)no3)CO2)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:39.891983
339338nanC[C@H]1CCCC(=O)CCCCCc2cc(O)cc(O)c2C(=O)O1standard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:39.910667
340339nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
341340nanCCOC(=O)c1cn(CC)c2ccc(CCCN3CCN(CCC(=O)O[C@H]4[C@H](C)O[C@@H](O[C@H]5[C@H](C)[C@@H](O[C@@H]6O[C@H](C)C[C@H](N(C)C)[C@H]6O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]5C)C[C@@]4(C)OC)CC3)cc2c1=Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:39.985337
342341nanCC(=O)O[C@@H]1[C@H](OC(=O)C(C)C)[C@@H]2[C@@H](OC(C)=O)[C@@]34O[C@@]2(C)COC(=O)c2cccnc2C[C@@H](C)C(=O)O[C@@H]([C@H](OC(=O)c2ccc(=O)n(C)c2)[C@H](OC(C)=O)[C@@]13COC(=O)C(C)C)[C@]4(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
343342nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:40.057885
344343CHEMBL1315430CCC1OC(=O)C(C)[C@@H](O[C@H]2C[C@@](C)(OC)C(O)C(C)O2)C(C)[C@@H](O[C@@H]2OC(C)CC(N(C)C)C2O)[C@@](C)(O)CC(C)C(=O)[C@@H](C)C(O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL1315430_numbered.png2026-03-19 02:40:40.120731
345344nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccc(NC(=O)Cc3ccccn3)nc2)[C@H](C)[C@H]2OC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:40.186449
346345nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(-c5ccc(C)cc5)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:40.252482
347346CHEMBL4068569COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C(F)=C\C[C@H](C)OC2=Ostandard_macrolactone14.0failednon-ring atom 2 marked aromaticring_size_14/standard/numbered/CHEMBL4068569_numbered.png2026-03-19 02:40:40.272167
348347nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O/C=C\Cc2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2Cl)[C@H](C)[C@H]2OC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:40.337843
349348CHEMBL59405O=C(NC(Cc1ccccc1)C(O)CN1C/C=C\CCCCCCCC(c2ccccc2)OC1=O)O[C@H]1CO[C@H]2OCC[C@@H]12non_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
350349nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=C/c2cccc3cccnc23)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:40.409464
351350nanCC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N/C(C)=O)[C@H](C)[C@@H](OC/C(=N/OCc3ccc(-c4cccc(N)n4)s3)CO2)[C@]1(C)Ostandard_macrolactone14.0success14.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:40.477318
352351nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCc2ccc(Br)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:40.540590
353352nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=C/c2cccc3ncccc23)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:40.605576
354353nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccnc(NC(=O)Cc3ccccn3)c2)[C@H](C)[C@H]2OC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:40.672639
355354CHEMBL3967300C[C@@H]1OC(=O)c2c(O)cc(N3CCNC3=O)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1Cstandard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/CHEMBL3967300_numbered.png2026-03-19 02:40:40.691969
356355nanCC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)/C=C/c2ccc(O)c(O)c2)[C@@H](C)OC(=O)[C@@H](C)CNC(=O)[C@@H](C)NC1=Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
357356nanCCCCCCCCCCCCCCCCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:40.763278
358357nanCOc1ccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1OCstandard_macrolactone14.0failednon-ring atom 12 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:40.782894
359358nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc4ncccc43)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:40.849363
360359nanC=CCO[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)O[C@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@H](O)[C@H]1N(C)Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:40.912144
361360nanC[C@@H]1/C=C\[C@@H](C)[C@H](/C=C/C#C/C=C/C(C)(C)[C@H](O)c2cccc(O)c2Br)OC(=O)/C=C\C[C@H](C)C[C@H](OC(N)=O)C1standard_macrolactone14.0success5.0[3, 4, 7, 9, 11]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:40.947112
362361nanCC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1cccc2ccccc12)CC(=O)O3standard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:40.966430
363362nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCN(C)Cc3ccccc3)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:41.031399
364363nanCCCCCCC(=O)O[C@H]1[C@H](C)OC(O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc3ccccc3)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OCstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:41.100937
365364nanCC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2Cstandard_macrolactone14.0success12.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:41.167066
366365nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:41.236465
367366nanC[C@@H]1C/C=C\C(=O)O[C@H](C)C[C@@H](O)C/C=C\C(=O)O1non_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
368367nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nncs3)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:41.311335
369368nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCCNCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:41.381027
370369nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCc3ccnc4c(OC)cccc34)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:41.446660
371370nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C[C@@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
372371nanCCCCC[C@H]1CCCCC[C@@H](O)C[C@H](O)[C@H](O)/C=C/C(=O)O1standard_macrolactone14.0success4.0[3, 9, 11, 12]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:41.486791
373372nanC[C@@H]1C[C@@H](O)/C=C\CCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1standard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:41.506440
374373nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2C(NC(=O)CCCCc3cnc4c(OC)cccc4c3)C(=O)O[C@@]21Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:41.572884
375374nanCC[C@H]1OC(=O)[C@H](C)C(O[C@H]2C[C@](C)(OC)[C@@H](O)[C@@H](C)O2)[C@H](C)C(O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCOc2ccc(OC)cc2)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:41.637433
376375nanCC/C=N/C(=O)CCCCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OCstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:41.702176
377376nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
378377nanCOc1cc(OCC(=O)NC(C)C)cc2c1C(=O)OC(C)CCCC(=O)CCCCC2standard_macrolactone14.0failednon-ring atom 2 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:41.731233
379378nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](N(C)C(C)C)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:41.801516
380379nanCOc1cc2c(c(OC)c1)C(=O)O[C@@H](C)CCC[C@@H](O)CCCCC2standard_macrolactone14.0failednon-ring atom 2 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:41.821495
381380nanCCC(=O)O[C@H]1[C@@H](OC(C)=O)[C@]2(COC(C)=O)[C@@H](OC(=O)c3ccccc3)[C@@H](O)[C@@H]3OC(=O)[C@@H](C)[C@@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@@]2([C@H](OC(=O)c2ccccc2)[C@@H]14)[C@@]3(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
382381nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccncc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:41.895772
383382nanCC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NC/C=C/c3ccc(NC(C)=O)cc3)C(=O)O[C@]12Cstandard_macrolactone14.0success12.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:41.956968
384383nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](OC(=O)c1cccnc1)[C@@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
385384nanCOC(=O)c1ccc(COc2cc(O)c3c(c2)C=CCCCC(=O)CCCC(C)OC3=O)o1standard_macrolactone14.0failednon-ring atom 10 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:41.983734
386385nanCOC(=O)c1cc(C(=O)OC)cc(-c2ccc(C3CC(=O)Oc4cc5c(c(OC)c43)C(=O)OC(C)CCCC(=O)CCCC=C5)o2)c1standard_macrolactone14.0failednon-ring atom 23 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:42.003932
387386CHEMBL83070C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)N2CCCCCC2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1standard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/CHEMBL83070_numbered.png2026-03-19 02:40:42.024741
388387nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCCNCCN2CCCC2)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:42.087466
389388nanCCOC(=O)c1cn(C2CC2)c2ccc(CCCN3CCN(CCC(=O)O[C@H]4[C@H](C)O[C@@H](O[C@H]5[C@H](C)[C@@H](O[C@@H]6O[C@H](C)C[C@H](N(C)C)[C@H]6O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]5C)C[C@@]4(C)OC)CC3)cc2c1=Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:42.154199
390389nanCO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](OC(C)=O)[C@@H](C)C(=O)[C@@]3(CO3)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3OC(C)=O)[C@H]2C)O[C@@H](C)[C@@H]1OC(C)=Ostandard_macrolactone14.0success12.0[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:42.215673
391390nanC=C(CCC[C@@H](O)C[C@H](C)O)C[C@@H]1CC(=C)C[C@H](O)C/C(C)=C\[C@@H](O)CCCC(=O)O1standard_macrolactone14.0success5.0[3, 5, 7, 9, 11]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:42.249971
392391nanCO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@]3(CO3)C[C@H](C)[C@H](O[C@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]2C)O[C@@H](C)[C@@H]1Ostandard_macrolactone14.0success12.0[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:42.310860
393392nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OCCNCCCOCCOCCOCCCNc2ccc(Oc3ccccc3)cc2)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:42.373210
394393nanC=C[C@@H]1[C@H]2[C@H](/C=C/C=C/C=C/CCC)[C@H]2[C@@H]2C(=O)OC[C@]3(C)[C@H]4[C@@H]5C=C(CO)C[C@]6(O)C(=O)C(C)=C[C@H]6[C@@]5(O)[C@H](C)C[C@]43OC(=O)C/C=C\C=C[C@H]12non_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
395394nanCCC1OC(=O)C(C)C(=O)/C(C)=C/C(C)CC(C)C(=O)/C=C/C1Cstandard_macrolactone14.0success8.0[3, 4, 7, 8, 10, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:42.423894
396395CHEMBL528543C/C1=C/[C@@H](C)[C@H](O)[C@@H](O)/C=C/CC/C=C/C(=O)O[C@@H]1[C@H](C)C(=O)/C=C/CC1CC(=O)NC(=O)C1standard_macrolactone14.0success5.0[3, 4, 6, 7, 8]ring_size_14/standard/numbered/CHEMBL528543_numbered.png2026-03-19 02:40:42.459025
397396CHEMBL1095163CCCCOc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=Ostandard_macrolactone14.0failednon-ring atom 5 marked aromaticring_size_14/standard/numbered/CHEMBL1095163_numbered.png2026-03-19 02:40:42.477865
398397CHEMBL1094226C[C@@H]1OC(=O)c2c(O)cc(OCC(O)CO)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1Cstandard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/CHEMBL1094226_numbered.png2026-03-19 02:40:42.496102
399398nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCCC(=O)NCCc3ccc(O)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:42.561316
400399CHEMBL1256549CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCF)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL1256549_numbered.png2026-03-19 02:40:42.624562
401400nanCCCN1C(C)O[C@@H]2[C@@H](C)[C@@H]1[C@H](C)C[C@@](C)(O)[C@H](OC1OC(C)CC(N(C)C)C1O)[C@@H](C)[C@H](OC1CC(C)(OC)C(O)C(C)O1)[C@@H](C)C(=O)O[C@H](CC)[C@@]2(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:42.688426
402401CHEMBL4061009COc1cc(O)c2c(c1)CCC[C@H](O)[C@H](O)[C@@H](O)CCC[C@H](C)OC2=Ostandard_macrolactone14.0failednon-ring atom 2 marked aromaticring_size_14/standard/numbered/CHEMBL4061009_numbered.png2026-03-19 02:40:42.707924
403402nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(C(N)=O)s3)CO2)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:42.774289
404403nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3ccccc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
405404nanCOC1CC(O[C@@H]2C(C)C(=O)O[C@H](C)[C@H](C)C(OC(C)=O)C(C)C(=O)[C@]3(CO3)C[C@H](C)[C@H](OC3OC(C)CC(N(C)C)[C@H]3O)[C@H]2C)OC(C)[C@@H]1Ostandard_macrolactone14.0success12.0[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:42.847466
406405nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)[C@@H](N(C)C)[C@H](C)[C@@H](O)[C@@]12CO2standard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:42.918681
407406CHEMBL1099198COc1cc(O)c2c(c1)OCC[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
408407nanCC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C/C=C/Cn3cnc4cccnc43)C(=O)N[C@]12Cstandard_macrolactone14.0success14.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:42.996124
409408nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccncc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CC3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:43.062954
410409CHEMBL3948014CCNc1cc(O)c2c(c1)/C=C/C[C@@H]1OC(=O)O[C@@H]1C(=O)/C=C\[C@@H](C)[C@H](C)OC2=Ostandard_macrolactone14.0failednon-ring atom 3 marked aromaticring_size_14/standard/numbered/CHEMBL3948014_numbered.png2026-03-19 02:40:43.083455
411410nanC[C@@H]1C[C@@H](O)CCCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1standard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:43.103364
412411nanCCCCCN[C@@H]1[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@H]1Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:43.168010
413412CHEMBL1404947CO[C@@H]1C[C@H](O[C@H]2[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)C[C@@H](N(C)C)[C@@H]3OC(C)=O)[C@H](C)C[C@]3(CO3)C(=O)[C@H](C)[C@H](OC(C)=O)[C@H](C)[C@H](C)OC(=O)[C@@H]2C)O[C@H](C)[C@@H]1OC(C)=Ostandard_macrolactone14.0success12.0[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL1404947_numbered.png2026-03-19 02:40:43.231096
414413nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ncccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:43.322190
415414CHEMBL1269447CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCc2csc(C)n2)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL1269447_numbered.png2026-03-19 02:40:43.397467
416415nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@H]4Cnon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
417416nanCC1C/C=C/C(O)C(O)CC/C=C/c2cc(O)cc(O)c2C(=O)O1standard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:43.429644
418417CHEMBL3734946CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccccc3-c3cn(CCCCCC(=O)NO)nn3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL3734946_numbered.png2026-03-19 02:40:43.505189
419418nanC=CCCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@](C)(O)[C@H](OC(=O)CCC=C)[C@@H](C)C(=O)[C@H](C)C[C@]2(C)O)O[C@H](C)C[C@@H]1N(C)Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:43.569857
420419nanCO[C@@H]1/C=C\CC/C(C)=C\C/C(C)=C\C(=O)O[C@@H](CO)C1standard_macrolactone14.0success4.0[3, 5, 10, 13]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:43.603493
421420CHEMBL3986872C[C@@H]1OC(=O)c2c(O)cc(NCCn3ccnc3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1Cstandard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/CHEMBL3986872_numbered.png2026-03-19 02:40:43.629993
422421nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCCCCc3ccnc4ccccc34)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:43.708347
423422nanCC[C@H](C)[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@H](OC)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(C)=O)[C@H]1Cstandard_macrolactone14.0success11.0[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:43.775057
424423nanC=C1NC(=O)C(C)C(CCC(C)C(=O)/C=C/C(C)=C/CCC(C)CCCCCC)OC(=O)C(CCC(N)=O)NC(=O)C(C)CNC1=Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
425424nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)/C=C/c2ccc(F)cc2)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:43.850266
426425nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:43.914232
427426nanCOc1cc(O)c2c(c1Br)C(=O)OCC(=O)N(C)CC(=O)N[C@H](c1nc(C)no1)CSC2non_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
428427nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(C)=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:43.988368
429428nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](OC(=O)NCCc3ccccc3)[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OC(=O)NCCc2ccccc2)[C@H](C)[C@H]2OC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:44.059629
430429nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\Oc3ccc(-c4nccs4)nc3)CO2)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:44.126074
431430nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\O)[C@H](C)[C@H]2OC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:44.192837
432431CHEMBL3577622C#CCO[C@@H]1[C@@H](C)[C@H](OC(=O)NCCCCCCCNC(=N)NC(=O)NC)[C@@H](C)C(=O)O[C@H](CC)C(C)(C)[C@@H]2OC(C)(C)O[C@H]([C@@H]2C)[C@H](C)C[C@@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL3577622_numbered.png2026-03-19 02:40:44.256920
433432nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)C(C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:44.321927
434433CHEMBL125014CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)N[C@H]1COC(=O)CCCC(CNC(=O)OCC(Cl)(Cl)Cl)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
435434CHEMBL1079557O=C(C[C@@H]1C/C=C/CCCCC(=O)OCCNC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
436435nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCCC(=O)NCc3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:44.406086
437436nanCC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCc3ccccc3)C(=O)O[C@]12Cstandard_macrolactone14.0success12.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:44.471644
438437nanCO[C@@H]1C[C@H]2C=C[C@H]3C[C@H]4O[C@]2(/C(C)=C\[C@@H]2COC(=O)CCC5=C(/C=C\OC[C@H](O)[C@H]2OC1=O)C(=O)OC5=O)[C@@H]3[C@@H](O)[C@H]4Cnon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
439438nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCC[C@@H]2c2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:44.550263
440439nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=N\OCc3cc(-c4ccc(Br)s4)no3)CO2)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:44.617177
441440nanCOC(=O)c1ccc(-c2ccc(C3CC(=O)Oc4cc5c(c(O)c43)C(=O)OC(C)CCCC(=O)CCCC=C5)o2)cc1standard_macrolactone14.0failednon-ring atom 18 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:44.637172
442441nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc4cccnc43)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:44.715590
443442nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:44.784822
444443nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2nccs2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:44.860618
445444nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CCCCO2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)C2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:44.930151
446445nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cccs2)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:44.995818
447446CHEMBL572017C/C=C1/[C@H]2OC=C(C(=O)O)[C@H]1CC(=O)OC[C@H](c1ccc(O)c(O)c1)OC[C@H]1O[C@@H](O2)[C@H](O)[C@@H](O)[C@@H]1Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
448447nanCO[C@]1(C)C[C@H](O[C@@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](C3CC3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:45.070019
449448nanCC[C@@H]1OC(=O)[C@@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@](C)(O[C@@H]2C[C@H](N(C)C)[C@H](O)[C@@H](C)O2)C[C@@H](C)C(=O)[C@H](O)[C@@H](O)C1(C)Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:45.137819
450449nanC[C@H]1C/C=C/[C@@H](O)[C@@H](O)CCC(O)Cc2cc(O)cc(O)c2C(=O)O1standard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:45.157803
451450nanCC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccnc4ccccc34)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:45.224348
452451nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:45.301404
453452nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCCCCOCC#Cc3ccc4c(c3)c(=O)c(C(=O)O)cn4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:45.371483
454453nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C/C=C/Cc3ccccc3)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:45.441041
455454nanC[C@H]1C/C=C/CC/C=C/C(=O)Cc2cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc(O)c2C(=O)O1standard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:45.461900
456455nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NN(CC)CCc2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:45.531898
457456nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCCO)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:45.600536
458457nanCC1CCCC(=O)CCCC=Cc2cc(O)cc(O)c2C(=O)O1standard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:45.619637
459458nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@](C)(F)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success14.0[3, 4, 4, 5, 6, 7, 8, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:45.688221
460459nanCC(=O)OC[C@@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
461460nanCOc1cc(O)c(Cl)c2c1C(=O)O[C@@H](C)CCC(=O)CCCCC(=O)C2standard_macrolactone14.0failednon-ring atom 2 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:45.715285
462461nanCCCCCCCN[C@@H]1[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@H]1Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:45.780717
463462CHEMBL216252CCC(C)N(CC1CC1)[C@H]1C[C@@H](C)OC(O[C@@H]2[C@@H](C)[C@H](OC3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCc4ccc(Cl)cc4)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@]2(C)OC)[C@@H]1Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL216252_numbered.png2026-03-19 02:40:45.849975
464463nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCCN(C)C)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:45.911243
465464nanO=C1OCC/C=C/CC/C=C/C(=N/OCC(=O)N2CCCCC2)Cc2cc(OP(=O)(O)O)cc(O)c21standard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:45.930148
466465CHEMBL3735212CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3cccc(-c4cn(CCCCCC(=O)NO)nn4)c3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL3735212_numbered.png2026-03-19 02:40:45.993842
467466CHEMBL3970233CN1Cc2cc(ccc2S(=O)(=O)C2CC2)NC(=O)OCc2cccc(c2)[C@@H](Nc2ccc3c(N)nccc3c2)C1=Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
468467nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCCNCCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:46.063701
469468nanCOc1cc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc(OC)c1OCstandard_macrolactone14.0failednon-ring atom 11 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:46.083366
470469nanCC1C(=O)OCCCn2ccc(c2)COC(=O)C(C)(O)C1(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
471470nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nc(-c4cccnc4)c[nH]3)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:46.167041
472471nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1Cstandard_macrolactone14.0success12.0[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:46.229433
473472nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4ccccc4)C3)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:46.306529
474473nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)c2ccc(C(C)(C)C)cc2)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:46.368446
475474nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccnc4ccc(OC)cc34)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:46.432743
476475nanCC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)/C(C)=C/[C@]1(C)OC(=O)NCCCOc1ccc2ccccc2c1standard_macrolactone14.0success11.0[3, 4, 4, 6, 7, 8, 10, 10, 11, 12, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:46.488014
477476nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2cncc3ccccc23)[C@H](C)[C@H]2OC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:46.553099
478477nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3ccnc3)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:46.616192
479478CHEMBL267568CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CC(C)OC2=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL267568_numbered.png2026-03-19 02:40:46.683083
480479CHEMBL1095165C[C@@H]1OC(=O)c2c(O)cc(C(O)(F)F)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1Cstandard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/CHEMBL1095165_numbered.png2026-03-19 02:40:46.702677
481480nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:46.770445
482481nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2CC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:46.834635
483482nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2ccc(-c3nnn(C)n3)s2)C[C@@H](C)/C(=N\OC)[C@H](C)[C@H]2NC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:46.898134
484483nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3ccccc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
485484nanCC[C@H](/C=C(\C)[C@@H]1C[C@@H](OC)C[C@H](O)C(C)(C)[C@@]2(O)O[C@@H](C[C@@H](OC)[C@H](O)C(=O)O1)C[C@@H](OC)[C@H]2O)COnon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
486485nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:46.978250
487486nanCC(C)(C)[C@H]1COC(=O)CCCC/C=C\C[C@H](CC(=O)NCCO)C(=O)N1non_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
488487CHEMBL574429CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL574429_numbered.png2026-03-19 02:40:47.050152
489488nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@H]4Cnon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
490489CHEMBL1080987O=C(C[C@H]1C/C=C/CCCCC(=O)OCCNC1=O)NCc1ccc(Cl)cc1non_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
491490nanCC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)N/C=C/c2ccc(-c3cccnc3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:47.129954
492491nanCC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(Cc3ccccc3)C(=O)O[C@]12Cstandard_macrolactone14.0success12.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:47.193218
493492nanCOc1cc(O)cc2c1C(=O)O[C@@H](C)CCCC(=O)CCCCC2standard_macrolactone14.0failednon-ring atom 2 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:47.212983
494493nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
495494nanCO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C3CC3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1Ostandard_macrolactone14.0success12.0[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:47.302139
496495nanCC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)N/C=C/c2ccc3cccnc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:47.369516
497496nanC[C@H]1C/C=C/[C@@H](O)[C@@H](O)CCC(=O)Cc2cc(O)cc(O)c2C(=O)O1standard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:47.390008
498497nanC[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)N2CCC(O)CC2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1standard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:47.410689
499498nanCCCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OCstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:47.477362
500499nanC[C@@H]1C[C@@H]2O[C@H]2/C=C\C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1standard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:47.497752
501500nanCOc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@@H](O)C(=O)/C=C/C[C@H](C)OC2=Ostandard_macrolactone14.0failednon-ring atom 2 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:47.517281
502501CHEMBL273535CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)O[C@H](C)[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL273535_numbered.png2026-03-19 02:40:47.586091
503502nanC=CCO[C@@H]1C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccc2Cl)[C@H](C)[C@H]1OC1O[C@H](C)C[C@H](N(C)C)[C@H]1Ostandard_macrolactone14.0success12.0[3, 4, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:47.651707
504503nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)C(=NC(C)=O)[C@H](C)C(OC/C(=N/OCc3ccccc3)CO2)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:47.720586
505504nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(-c5ccccc5Cl)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)Ostandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:47.790492
506505CHEMBL418256CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/CHEMBL418256_numbered.png2026-03-19 02:40:47.860980
507506CHEMBL3828395COc1cc(O)c2c(c1)/C=C/CCC[C@@H](O)CCC[C@H](C)OC2=Ostandard_macrolactone14.0failednon-ring atom 2 marked aromaticring_size_14/standard/numbered/CHEMBL3828395_numbered.png2026-03-19 02:40:47.880970
508507nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OCCCc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2Cl)[C@H](C)[C@H]2OC(=O)O[C@]12Cstandard_macrolactone14.0success13.0[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]ring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:47.950041
509508nanCC1CCCC(=O)CCCC=Cc2cc(OC(=O)c3ccccc3)cc(OC(=O)c3ccccc3)c2C(=O)O1standard_macrolactone14.0failednon-ring atom 0 marked aromaticring_size_14/standard/numbered/nan_numbered.png2026-03-19 02:40:47.970281
510509nanCC(=O)OC[C@]12[C@H](O)C(=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle14.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
511510CHEMBL1774639CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCN(CCC#N)C(=S)NCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
512511CHEMBL3774592C=C1/C=C/C(=O)N(C)CC(=O)N[C@@H]([C@H](O)C(N)=O)C(=O)O[C@@H]([C@H](C)CCCCCCCCCCCCC(C)C)[C@H](C)C(=O)N1non_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
513512CHEMBL89179CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCc2cccnc2)CCCCNC(=O)OCCC[C@@H]1C(=O)NOnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
514513CHEMBL89747CCOC(=O)N1CCN(C(=O)CNC(=O)[C@@H]2CCCCN(C)C(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N2)CC1non_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
515514CHEMBL2029743CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2ccc3ccccc3n2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
516515nanCC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H]2[C@@H](OC(C)=O)[C@@]34O[C@@]2(C)COC(=O)c2cccnc2CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c2ccccc2)[C@H](OC(C)=O)[C@@]13CO)[C@]4(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
517516nanCC(C)[C@@H]1OC(=O)C(C)(C)[C@@H](O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](C(C)C)OC(=O)[C@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC1=Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
518517nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCCCc2ccccn2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
519518nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
520519nanC=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
521520CHEMBL4068622C=C1/C=C/C(=O)N[C@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCOC(=O)CP(=O)(OCC)OCC)C(=O)N1non_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
522521nanCC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)OC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(I)cc2)NC1=Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
523522nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CCC(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
524523CHEMBL3218564CCCC[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)N[C@H](CC(C)C)[C@@H](O)CC(=O)O2non_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
525524nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(C#CCN(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
526525CHEMBL1774293CCNC(=O)N1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1Cnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
527526nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccccc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccncc2)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
528527nanCC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(Cc4ccncc4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2Cnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
529528nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccc(C)cc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
530529nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2OC(=Nc2ccc(OC)cc2)N3C)[C@](C)(OC)C[C@@H](C)C(=O)N[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
531530nanCCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNCCCNCCOCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
532531nanCO/C1=C(/C(C)C)CC/C=C(/C)C2OC(C)(O)C3C(=O)O/C(=C(/C)CCC(C)OC1=O)C23standard_macrolactone15.0success8.0[3, 6, 7, 8, 9, 10, 14, 15]ring_size_15/standard/numbered/nan_numbered.png2026-03-19 02:40:48.189815
533532nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(=O)c3ccccc3)[C@@H]3OC(=O)[C@@H](C)CCc4ncccc4C(=O)OC[C@]4(C)O[C@]1([C@H](O)[C@@H]4[C@@H](OC(C)=O)[C@H]2OC(C)=O)[C@@]3(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
534533nanCC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
535534nanCC(=O)OC[C@@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]3[C@@H](OC(C)=O)[C@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@H](C)C(=O)O[C@H]([C@@H](OC(=O)c1ccco1)[C@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
536535CHEMBL89034CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCOCC2)CCCCN(C)C(=O)OCCC[C@@H]1C(=O)NOnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
537536nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CN(CC)CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)N[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
538537nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccc(C)cc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(OC)cc2)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
539538nanCC[C@H](C)[C@@H]1OC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)C/C(C)=C\[C@H](C)[C@@H](O)/C(C)=C\[C@@H]1Cnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
540539CHEMBL3601578CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(Cc2ccc(-c3cn(CCn4ccc5cc([N+](=O)[O-])ccc54)nn3)cc2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
541540nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCNc3cc4c(=O)c(C(=O)OC(C)C)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
542541nanCOc1c(Br)cc2cc1Oc1ccc(cc1)CC(O)COC(=O)CC2non_standard_macrocycle15.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
543542nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(OC(C)=O)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
544543CHEMBL553625CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=S)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
545544nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccc(F)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2Cl)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
546545nanCCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNCCCNCCOCCOCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
547546nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(OC(C)=O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
548547nanCC[C@@H]1CCC(=O)O[C@H]2[C@H](C)[C@@]34O[C@](C)(COC(=O)c5cccnc51)[C@@H]([C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]3(COC(C)=O)[C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@@H]4OC(C)=Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
549548nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccco1)[C@@H]2OC(C)=O)[C@@]4(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
550549CHEMBL3775644C=C1/C=C/C(=O)N(C)CC(=O)N[C@H]([C@@H](O)C(=O)OC)C(=O)O[C@@H]([C@H](C)CCCCCCCCCCCC(C)C)[C@H](C)C(=O)N1non_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
551550CHEMBL1682468CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(Cl)cc2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
552551nanCO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN(C)C[C@H](COc3ccc(-c4cccnc4)cc3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
553552nanCC(C)C[C@@H]1OC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC1=Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
554553CHEMBL1682595CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NC2CC3C=CC2C3)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
555554nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CN(CCO)CCO)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
556555CHEMBL539222CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=S)NCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
557556CHEMBL313936CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCCc2ccccn2)CCCCNC(=O)OCCC[C@@H]1C(=O)NOnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
558557CHEMBL557551CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
559558CHEMBL553222CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
560559nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCc2ccccc2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
561560nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCOc3cc4c(=O)c(C(=O)OCOC(=O)C(C)(C)C)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
562561nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCO[C@@H]3O[C@H](CO)[C@@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12Cnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
563562nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCCc3cc4c5c(c3)c(=O)c(C(=O)O)cn5C(C)(C)CO4)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
564563CHEMBL3775914COC(=O)[C@H](O)[C@H]1NC(=O)CN(C)C(=O)/C=C/[C@@H](CO)NC(=O)[C@H](C)[C@@H]([C@@H](C)CCCCCCCCCCCC(C)C)OC1=Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
565564nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CNC(C)(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
566565nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NC(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
567566CHEMBL431008CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCN(C)CC2)CCCCN(C)C(=O)OCCC[C@@H]1C(=O)NOnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
568567nanC=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCN2CCN(c3ccc(F)cc3)CC2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
569568CHEMBL315276CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCN(C)CC2)CCCCNC(=O)OCCC[C@@H]1C(=O)NOnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
570569nanCC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4cccc(OC)c4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2Cnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
571570CHEMBL1682576CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccccc2F)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
572571nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
573572nanCC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4cc5ccccc5[nH]4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2Cnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
574573CHEMBL1682465CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2cccc3nsnc23)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
575574nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@@]2(O)[C@@H](C)C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(Cl)[C@@H](O)C[C@@]32C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
576575CHEMBL1682451CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2cccc3nsnc23)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
577576CHEMBL3352926C=C1/C=C/C(=O)N(C)CC(=O)NC(C(O)C(N)=O)C(=O)OC(C(C)CCCCCCCCCCCCC(C)C)C(C)C(=O)N1non_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
578577CHEMBL350938COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](Cc3ccccc3)NC2=O)cc1Clnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
579578CHEMBL2029761CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Cc2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
580579nanCC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4cccnc4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2Cnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
581580CHEMBL2029589CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNc2ccnc3cc(Cl)ccc23)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
582581nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3cc([N+](=O)[O-])cc([N+](=O)[O-])c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(F)c(F)c2)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
583582nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccccc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
584583nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccccc4Cl)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
585584CHEMBL1682453CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc([N+](=O)[O-])cc2OC)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
586585CHEMBL541735CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=O)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
587586nanO=C1CCc2ccc(O)c(c2)Oc2ccc(cc2)[C@H]2O[C@@H]2CO1non_standard_macrocycle15.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
588587nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCCCc2ccccc2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
589588nanCCC1OC(=O)C(C)[C@@H](O[C@H]2C[C@@](C)(OC)C(O)C(C)O2)C(C)[C@@H](O[C@@H]2OC(C)CC(N(C)C)C2O)[C@@](C)(O)CC(C)CN(C)C(C)C(O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
590589nanC=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCN(C)CCc2ccccc2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
591590nanCC(C)CC1NC(=O)C(C(C)C)NC(=O)C(CC(C)C)OC(=O)C(CC(C)C)NC(=O)C(Cc2ccccc2)NC1=Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
592591CHEMBL2029585CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
593592nanC=C1CC[C@H](Br)[C@@]2(C)CC[C@@H](Br)[C@@](C)(O)CC[C@@H](C(C)(C)Br)OC(=O)c3ccc(O)c(c3)C[C@H]12standard_macrolactone15.0failednon-ring atom 0 marked aromaticring_size_15/standard/numbered/nan_numbered.png2026-03-19 02:40:48.697878
594593nanCCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccc(Br)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccc(OC)cc2)C1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
595594CHEMBL2029749CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2ccnc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
596595CHEMBL4072704CCCCCC[C@@H](C)[C@@H]1OC(=O)[C@H](C(C)C)NC(=O)[C@@H](C)NC(=O)/C=C/[C@H](CO)NC(=O)[C@H]1CCOCc1ccccc1non_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
597596nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@](O)(CSCCO)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
598597nanCO/N=C/C=C/C(=O)N/C=C/C[C@@H]1CC(=O)O[C@@H](CO)/C=C\[C@@H](O)/C(C)=C\Cc2cccc(O)c2C(=O)O1non_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
599598CHEMBL88906CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCC(C(=O)O)CC2)CCCCNC(=O)OCCC[C@@H]1C(=O)NOnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
600599CHEMBL349460COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C(C)C)NC2=O)cc1Clnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
601600CHEMBL509784OPPOSITINE ACCC1CCC(=O)O[C@H]2[C@H](OC(C)=O)[C@H](OC(=O)c3ccccc3)[C@@]3(COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]4[C@@H](OC(C)=O)[C@]3(O[C@]4(C)COC(=O)c3cccnc31)[C@@]2(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
602601nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc(Cl)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12Cnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
603602CHEMBL2314758CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@H]2[C@H](C)C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@@]32C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
604603nanCC(=O)OC[C@@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@@H](O)[C@@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
605604nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(=O)[C@H](C)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]4(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
606605CHEMBL1682447CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NC(c2ccccc2)c2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
607606nanCOc1ccc(C[C@@H](C(=O)O[C@H](C)[C@H](NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](C)O)C(=O)N2CCCCNC(=O)[C@@H](C)C(=O)[C@H](C(C)C)OC(=O)C[C@H](O)[C@H]2CC(C)C)N(C)C(C)=O)cc1non_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
608607CHEMBL2029591CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNc2cc(C)nc3ccc(OC)cc23)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
609608nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3ccc4c(=O)c(C(=O)O)cn(C5CC5)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
610609CHEMBL1774626CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCNC(=O)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
611610nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(OC(C)=O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
612611nanCC[C@H](C)[C@H]1OC(=O)C(C)(C)[C@H](O)[C@H](Cc2ccccc2)OC(=O)[C@@H](C(C)C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC1=Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
613612nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3cccc4ccccc34)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
614613nanCCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccc(Cl)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccc(OC)cc2)C1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
615614nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4N(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
616615nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@@]4(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
617616nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](N)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)OCC2c3ccccc3-c3ccccc32)[C@](C)(O)C[C@@H](C)N(CCF)C[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
618617nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCc2cccnc2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
619618CHEMBL1682607CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NC(=O)c2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
620619nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN(C)CCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12Cnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
621620nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4c(Cl)cccc4Cl)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
622621nanCC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ncccn4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2Cnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
623622CHEMBL3358523C[C@H]1CCCC(=O)N(C)/C=C/CC[C@H](C)C(=O)O[C@H](C(C)(C)C)C1non_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
624623nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]4(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
625624nanCCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]3OC(=O)O[C@]3(C)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OCnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
626625nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](N)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
627626nanC/C=C\C/C=C/[C@H](C)C[C@H](O)[C@H]1C[C@@H]2O[C@H]2/C=C\[C@@H](O)[C@@H](O)/C=C\C[C@H](C)CC(=O)O1standard_macrolactone15.0success6.0[3, 5, 6, 9, 10, 14]ring_size_15/standard/numbered/nan_numbered.png2026-03-19 02:40:49.006018
628627nanCC[C@H]1OC(=O)/C(C)=C\[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN(C(=O)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
629628nanCC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4ccc(NC(C)=O)cc4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2Cnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
630629CHEMBL1682459CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(Cl)c(Cl)c2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
631630CHEMBL4098570C=C1/C=C/C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)O[C@H]([C@@H](C)CCCCCC)[C@@H](CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C(=O)N1non_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
632631nanCO/N=C/C=C\C(=O)N/C=C/C[C@@H]1CC(=O)O[C@@H](C)/C=C\[C@@H](O)/C(C)=C\Cc2cccc(O)c2C(=O)O1non_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
633632CHEMBL2029763CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@H](C)c2ccc3cc(OC)ccc3c2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
634633nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C(=O)Nc2cccc(C(F)(F)F)c2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
635634nanC/C=C/C/C=C\[C@H](C)C[C@H](O)[C@H]1C[C@@H]2O[C@H]2/C=C\[C@@H](O)[C@@H](O)/C=C\C[C@H](C)CC(=O)O1standard_macrolactone15.0success6.0[3, 5, 6, 9, 10, 14]ring_size_15/standard/numbered/nan_numbered.png2026-03-19 02:40:49.094240
636635nanC[C@@H]1CC=CCCCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1standard_macrolactone15.0failednon-ring atom 0 marked aromaticring_size_15/standard/numbered/nan_numbered.png2026-03-19 02:40:49.113506
637636CHEMBL1682467CCOC(=O)c1ccc(NC(=S)NCCCN2C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]2C)cc1non_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
638637nanCCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)(CN(C)Cc3ccc(-c4cn(CCCCC(=O)NO)nn4)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
639638nanCC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
640639nanC=CCN1C(=O)O[C@H]2[C@H](O[C@@H]3[C@@H](C)[C@H](O[C@H]4C[C@@](C)(OC)[C@@H](O)[C@H](C)O4)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@]3(C)O)O[C@H](C)C[C@@H]21non_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
641640CHEMBL1682461CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccc3c(c2)CCC3)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
642641CHEMBL1773086CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
643642CHEMBL3822850COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc2ccc3cc(-c4ccc(-c5c[nH]c([C@@H]6C[C@@H]7CN6C(=O)[C@H](C(C)C)NC(=O)OCCC/C=C/CO7)n5)cc4)ccc3c2[nH]1)C(C)Cnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
644643nanCCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OCnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
645644nanCC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4ccccc4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2Cnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
646645nanC=C[C@@]1(O)[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OCnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
647646nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCC(=O)NCCOCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
648647nanCON1O/C=C\C=C(N)/C=C\C[C@@H]2CC(=O)O[C@H](CO)/C=C\[C@@H](O)/C(C)=C\Cc3cccc(c3C(=O)O2)O1non_standard_macrocycle15.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
649648nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCCNC(=O)CCCNc3ccnc4ccccc34)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
650649CHEMBL1682713C=CCNC(=S)NCCCN1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1Cnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
651650CHEMBL1774291C=CCN1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1Cnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
652651nanCC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccncc1)[C@@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
653652nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C(N)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
654653CHEMBL3358522C[C@@H]1CCCC(=O)N(C)CCCC[C@@H](C)C(=O)O[C@@H](C(C)(C)C)C1non_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
655654nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
656655nanCC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC2CO2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
657656nanCO[C@@H]1COC(=O)[C@H]2CCCN2C(=O)[C@@H](C)COC(=O)C/C=C\[C@H]1Cnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
658657CHEMBL4095942C=C1/C=C/C(=O)N[C@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCOC(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)N1non_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
659658nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
660659nanCC(=O)OC[C@@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
661660CHEMBL1682574CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2cccc(Cl)c2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
662661nanCC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12Cnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
663662CHEMBL1682581CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccccc2-c2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
664663nanCC#C[C@@]1(O)[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OCnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
665664nanCCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccco3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccc(OC)cc2)C1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
666665nanCC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4c[nH]c5ccccc45)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2Cnon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
667666nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4N(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
668667CHEMBL1946558CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCCNc3ccnc4ccc(Cl)cc34)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
669668nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCOc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
670669CHEMBL1682608CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(N(CC)CC)cc2)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
671670nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCCCOCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)Onon_standard_macrocycle15.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
672671nanO=C1CCCCCCCCCCC(=NOC(=O)COc2cccc([N+](=O)[O-])c2)CCCO1standard_macrolactone16.0success1.0[6]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:49.418322
673672nanCC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(CC)CC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1Cstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:49.469746
674673nanCC1CCCCCCCCCCCCCOC1=Ostandard_macrolactone16.0success1.0[16]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:49.492984
675674nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2OC(C)=O)[C@@H](CCOc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OCstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:49.552572
676675CHEMBL435458COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)c3ccccc3NC2=O)cc1Clnon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
677676nanCCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)OCCC(/C=C/Cc4cncc5ccccc45)CN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
678677nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCOS(=O)(=O)c2ccc(C)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1OCstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:49.629166
679678nanCC[C@@H]1OC(=O)CCC/C=C\C/C=C\C/C=C\[C@H]2[C@H]1C[C@@H](O)[C@@H]2Ostandard_macrolactone16.0success3.0[3, 4, 5]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:49.661546
680679nanCC(C)[C@@H]1NC(=O)[C@@H](NC(=O)c2ccccc2)[C@@H](C)OC(=O)[C@@H]2CCCCN2C(=O)[C@@H]2CCCCN2C(=O)[C@@H]2CCCN2C1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
681680nanO=C1CCCCCCCCC(=O)OCCCCO1non_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
682681nanCO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\[C@H]2O[C@@H]2C[C@@H](C)OC(=O)C[C@H]1OC(C)=Ostandard_macrolactone16.0success9.0[3, 5, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:49.728229
683682CHEMBL328208Cc1nc2cc([C@@H]3C[C@@H]4O[C@]4(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O3)ccc2n1Cstandard_macrolactone16.0success11.0[3, 5, 6, 6, 10, 11, 12, 13, 14, 14, 15]ring_size_16/standard/numbered/CHEMBL328208_numbered.png2026-03-19 02:40:49.783221
684683nanCO[C@H]1[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@@H](CC=O)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O2)[C@H](N(C)C)[C@H]1Ostandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:49.829878
685684nanCCC1CC(C)C(=O)/C=C\C=C/CC(C)OC(=O)CC(O)C(OC)C1OC1OC(C)CC(N(C)C)C1Ostandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:49.872986
686685CHEMBL103638COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c3cccc(C)c3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Clnon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
687686nanC/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@H](C)[C@@H](O)CC(=O)O1standard_macrolactone16.0success9.0[3, 5, 6, 10, 11, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:49.929229
688687nanCC[C@@H](C)[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CCCCCCCCc2ccc(O)cc2)[C@@H](C)OC1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
689688nanO=C1CCCCCCCCCCC(=NOC(=O)COc2ccccc2Cl)CCCO1standard_macrolactone16.0success1.0[6]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:49.959364
690689nanCO[C@@H]1[C@@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](OC(C)=O)[C@H](C)O3)[C@H](N(C)C)[C@@H]2O)[C@@H](CC=O)C[C@H](C)[C@@H](O)/C=C\C=C/C[C@H](C)OC(=O)C[C@H]1Ostandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:50.006526
691690nanCOc1ccc(C[C@H]2NC(=O)/C=C\C[C@@H]([C@H](C)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1Clnon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
692691nanC=C1Oc2cc(OC)cc(C(=O)O[C@@H]3COC(=O)C[C@H](N)c4cc(O)c(c(Cl)c4)O[C@@H]4c5ccc3c(Cl)c5C3=CC=C[C@@]34O[C@H]3OC(C)(C)[C@H](N(C)C)[C@H](O)[C@@H]3O)c2NC1=Onon_standard_macrocycle16.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
693692nanCO[C@@H]1[C@@H](OC[C@@H]2[C@H](C)OC(=O)CC[C@@H](C)[C@@H](O[C@H]3O[C@@H](C)C[C@@]4(OC(=O)O[C@H]4C)[C@@H]3O)[C@@H](C)C[C@H](C)C(=O)/C=C\[C@@H]3O[C@H]32)O[C@@H](C)[C@@H](O)[C@@H]1OCstandard_macrolactone16.0success9.0[3, 4, 5, 6, 9, 10, 12, 13, 14]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:50.076175
694693nanCCNCC[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](C)[C@@H](CC)OC(=O)CC(O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1Ostandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:50.127404
695694nanCC(C)C[C@@H]1OC(=O)[C@H](C)CNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)/C=C\C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
696695nanCC[C@H](C)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@H](C(C)C)NC(=O)C[C@@H](/C=C/c2ccccc2)OC(=O)[C@H](C(C)C)NC1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
697696nanC/C1=C/C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC1standard_macrolactone16.0success9.0[3, 6, 10, 11, 12, 13, 14, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:50.188666
698697nanCC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(C)CCCN(C)C(=O)CNC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1Cstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:50.239663
699698nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C(C)=O)C2O)[C@@H](CC(OC)OC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1OC(C)C(O)C(OC)C1OCstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:50.292451
700699nanC/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@@H](C)[C@@H](O)CC(=O)O1standard_macrolactone16.0success9.0[3, 5, 6, 10, 11, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:50.340524
701700nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc(OC)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OCstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:50.392886
702701CHEMBL3317810C[C@@]12CSC(=N1)c1csc(n1)CNC(=O)C[C@@H](/C=C/CCS)OC(=O)[C@H](Cc1ccccc1)NC2=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
703702CHEMBL92285C/C1=C/C[C@@H](c2ccc3sc(C)nc3c2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC1standard_macrolactone16.0success9.0[3, 6, 10, 11, 12, 13, 14, 14, 15]ring_size_16/standard/numbered/CHEMBL92285_numbered.png2026-03-19 02:40:50.448671
704703nanCC(C)C[C@@H]1NC(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(C)C)OC1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
705704nanC/C=C1\NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](C)C[C@@H](C)CCC)[C@@H](C)OC1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
706705nanC[C@@H]1OC(=O)[C@@H](c2cc(O)cc(O)c2)NC(=O)[C@H](c2cc(O)cc(O)c2)NC(=O)[C@@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]1NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Cl)[nH]1non_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
707706CHEMBL433337CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](c2ccc(O)cc2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
708707nanCC[C@@H]1C[C@@H](C)C(=O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H](OC)[C@@H]1Ostandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:50.518800
709708nanCO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@@]2(OC)C[C@@H](O)[C@H](C)[C@@H](C(C)C)O2)OC1=Ostandard_macrolactone16.0success8.0[3, 4, 8, 10, 11, 12, 14, 16]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:50.565168
710709nanCO[C@H]1CCCCCCCCC[C@@H](C)OC(=O)CCC1=Ostandard_macrolactone16.0success3.0[3, 13, 14]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:50.593441
711710nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCCl)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OCstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:50.650044
712711nanC/C(=C\c1csc(C)n1)[C@@H]1CCCCCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)C(O)CC(=O)O1standard_macrolactone16.0success8.0[3, 10, 11, 12, 13, 14, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:50.697706
713712nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1OCstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:50.754037
714713nanC[C@H]1/C=C\CC/C=C\C=C/C/C=C\CCC(=O)O1standard_macrolactone16.0success1.0[3]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:50.776317
715714CHEMBL1531390CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@H](C)C/C(C)=C/C=C/[C@H](OC)[C@H]([C@@H](C)[C@@H](O)[C@H](C)[C@H]2C[C@@H](O)[C@H](C)[C@@H](C(C)C)O2)OC1=Ostandard_macrolactone16.0success8.0[3, 4, 8, 10, 11, 12, 14, 16]ring_size_16/standard/numbered/CHEMBL1531390_numbered.png2026-03-19 02:40:50.823419
716715nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2cc(Cl)cc(Cl)c2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OCstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:50.876642
717716nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2cccc(N(C)C)c2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OCstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:50.930704
718717nanCCC[C@@H]1OC(=O)[C@@H](C)[C@@H]2CC[C@H](C[C@@H](C)OC(=O)[C@@H](C)[C@H]3CC[C@H](O3)[C@H]1C)O2non_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
719718nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=N\OC/C=C/c2cnc3ccccc3c2)/C=C/C(C)=C/C1COstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:50.989168
720719nanCOC1C(OCC2C(C)OC(=O)/C=C\C(C)C(OC3OC(C)CC(O)C3O)CCC(C)C(=O)/C=C\C3OC32)OC(C)C(O)C1OCstandard_macrolactone16.0success8.0[3, 4, 5, 6, 9, 10, 13, 14]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:51.035532
721720nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc(C(=O)c3ccccc3)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OCstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:51.093027
722721CHEMBL42743TYLOSINCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OCstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/CHEMBL42743_numbered.png2026-03-19 02:40:51.147070
723722nanCOc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(=O)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1non_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
724723nanCC[C@H]1OC(=O)C[C@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3C[C@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O[C@H]2CC[C@@H](N(C)C)[C@@H](C)O2)/C=C\C(C)=C/[C@H]1Cstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:51.234438
725724nanCC[C@@H]1OC(=O)/C=C\[C@H](C)[C@H](O[C@H]2O[C@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](C)C[C@@H](C)C(=O)/C=C\C=C/[C@@]1(O)CO[C@H]1O[C@H](C)[C@@H](O)[C@H](O)[C@H]1OCstandard_macrolactone16.0success8.0[3, 4, 4, 9, 10, 12, 13, 14]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:51.283749
726725nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCO)C[C@@H](C)C(=O)/C=C\[C@@]2(C)O[C@@H]2[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OCstandard_macrolactone16.0success11.0[3, 4, 5, 6, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:51.342475
727726nanCCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/[C@@H](O)[C@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](OC(=O)CC)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@H]1OCstandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:51.390405
728727nanC/C1=C/[C@@H](C)C[C@@H](C)[C@@H](Cc2cnco2)OC(=O)/C(C)=C\[C@@H](C)C[C@@H](C)[C@@H](Cc2cnco2)OC1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
729728nanC/C1=C/[C@H](C)C[C@H](C)[C@H](Cc2cnco2)OC(=O)/C(C)=C\[C@@H](C)C[C@H](C)[C@H](Cc2cnco2)OC1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
730729nanCCOC(=O)/C=C/C[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](COC2OC(C)C(O)C(OC)C2OC)[C@@H](CC)OC(=O)C[C@@H](OC(=O)Cc2ccc([N+](=O)[O-])cc2)[C@H](C)[C@H]1OC1OC(C)C(O)C(N(C)C)C1Ostandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:51.456921
731730nanCC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=O)/C=C/[C@]2(C)O[C@H]2[C@@H]1Cstandard_macrolactone16.0success11.0[3, 4, 5, 6, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:51.517477
732731nanCOc1ccc(C[C@H]2NC(=O)/C=C\C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1non_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
733732nanCC[C@H]1OC(=O)C[C@@H](OC(C)=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OCstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:51.583110
734733CHEMBL3251867CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(=O)CC)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)Ostandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/CHEMBL3251867_numbered.png2026-03-19 02:40:51.632631
735734nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C(C)=O)C2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1OC(C)C(O)C(OC)C1OCstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:51.686696
736735nanCC1CC(=O)OC(C)C(O)/C=C/C(=O)OC(C)C(O)/C=C/C(=O)O1non_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
737736CHEMBL3934882Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(C3CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)ncc(F)c2c1non_standard_macrocycle16.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
738737nanCO[C@@H]1[C@@H](O)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](OC(C)=O)[C@H](C)C[C@H](CC=O)[C@H]1O[C@@H]1O[C@H](C)[C@H](O[C@@H]2C[C@@](C)(OC(C)=O)[C@@H](OC(C)=O)[C@@H](C)O2)[C@H](N(C)C)[C@H]1OC(C)=Ostandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:51.749402
739738CHEMBL3244607CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](N(C)C)[C@@H](OC(=O)CCC(=O)O)[C@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)O[C@@H]2C)C[C@@]1(C)Ostandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/CHEMBL3244607_numbered.png2026-03-19 02:40:51.796327
740739nanCC(=O)C[C@@H]1CCC(=O)/C=C\C(=O)O[C@H](CC(C)=O)CC[C@H](O)/C=C\C(=O)O1non_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
741740CHEMBL379989RHIZOXINCO[C@@H](/C(C)=C/C=C/C(C)=C/c1coc(C)n1)[C@@H](C)[C@@H]1C[C@H](O)[C@@]2(C)O[C@@H]2/C=C/[C@@H](C)[C@H]2C[C@H](CC(=O)O2)C[C@@H]2O[C@H]2C(=O)O1standard_macrolactone16.0success10.0[3, 5, 6, 6, 7, 10, 11, 13, 15, 16]ring_size_16/standard/numbered/CHEMBL379989_numbered.png2026-03-19 02:40:51.856222
742741nanC/C(=C\c1csc(C)n1)[C@@H]1CC2OC(C)(C)OC2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1standard_macrolactone16.0success10.0[3, 5, 6, 10, 11, 12, 13, 14, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:51.910215
743742nanC/C=C1\NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)/C(C)=C/C)C(C)C)[C@@H](C)OC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(=O)O)NC1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
744743nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](C/C=C/C(C)=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1OC(C)C(O)C(OC)C1OCstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:51.970831
745744CHEMBL2324838C=CCOC(=O)C[C@H]1CNC(=O)[C@@H](Cc2ccc(OC)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC(=O)[C@H](CC(C)C)OC1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
746745nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](C=O)C[C@@H](C)C(=N\OCCCc2ccc3ncccc3c2)/C=C/C(C)=C/C1COstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.029902
747746nanCOc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(=O)C#Cc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@@H](C)CNC2=O)cc1non_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
748747nanCCCON=C1CCCCCCCCCCC(=O)OCCC1standard_macrolactone16.0success1.0[6]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.057832
749748nanCO[C@H]1[C@H](OC[C@H]2/C=C/CCC(=O)[C@@](C)(O)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@](O)([C@H](C)O)[C@H]3O)[C@@H](C)/C=C/C(=O)O[C@@H]2C)O[C@H](C)[C@@H](O)[C@H]1OCstandard_macrolactone16.0success8.0[3, 4, 9, 10, 10, 12, 13, 14]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.105377
750749nanCC1CCCCCCCCCCCCCC(=O)O1standard_macrolactone16.0success1.0[3]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.126998
751750CHEMBL122232CCCC1(CCC)CNC(=O)[C@@H](Cc2ccc(OC)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c2ccccc2)OC(=O)[C@H](CC(C)C)OC1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
752751nanCCC1CC(C)C(O)/C=C/C=C/CC(C)OC(=O)CC(O)C(OC)C1OC1OC(C)CC(O)(C(C)=O)C1Ostandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.175593
753752nanCC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C/C=C5/OCC[C@@]6(O[C@H]6C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)[C@@H]5Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
754753nanCO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](NC3CCCCC3)[C@H](C)[C@@H](C(C)C)O2)OC1=Ostandard_macrolactone16.0success8.0[3, 4, 8, 10, 11, 12, 14, 16]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.227854
755754CHEMBL3251858CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](N(C)C)[C@@H](OC(C)=O)[C@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)O[C@@H]2C)C[C@@]1(C)Ostandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/CHEMBL3251858_numbered.png2026-03-19 02:40:52.273327
756755nanCCCC/C=C/C(=O)N[C@@H](Cc1cccc(F)c1)C(=O)N[C@@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H]2CC(C)CCN2C(=O)[C@@H]2CCCN2C1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
757756nanC/C(=C\c1coc(C)n1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1standard_macrolactone16.0success11.0[3, 5, 6, 6, 10, 11, 12, 13, 14, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.333782
758757nanCO[C@H]1[C@@H](OC(C)=O)CC(=O)O[C@H](C)C[C@@H]2O[C@@H]2/C=C\[C@H](O)[C@@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@@H]2C[C@](C)(O)[C@H](OC(=O)CC(C)C)[C@@H](C)O2)[C@H](N(C)C)[C@H]1Ostandard_macrolactone16.0success9.0[3, 5, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.385588
759758nanCCC(=O)O[C@H]1CC(=O)O[C@H](C)C/C=C\C=C/[C@H](C)[C@H](C)C[C@H](CC=O)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@@H](N(C)C)[C@H]2O)[C@@H]1OCstandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.429166
760759nanCO[C@@H]1[C@@H](OC(C)=O)CC(=O)O[C@@H](C)C/C=C\C=C/[C@H](O[C@@H]2C[C@@H](N(C)C)C[C@H](C)O2)[C@H](C)C[C@H](CC=O)[C@H]1O[C@@H]1C[C@H](C)[C@@H](O[C@@H]2C[C@](C)(O)[C@@H](O)[C@H](C)O2)[C@@H](N(C)C)[C@@H]1Ostandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.475452
761760CHEMBL3251860CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](N(C)C)[C@@H](OC(=O)CC)[C@H](O[C@@H]3[C@@H](OC)[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)O[C@@H]2C)C[C@@]1(C)Ostandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/CHEMBL3251860_numbered.png2026-03-19 02:40:52.521862
762761nanCC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN(C)CCCNC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OCstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.573139
763762CHEMBL403900POLYDISCAMIDE BCCC(C)(C)[C@H](NC(=O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(Br)cc1)NC(=O)[C@@H](C)NC=O)C(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CS(=O)(=O)O)C(=O)N[C@@H]1C(=O)N(C)[C@@H](CCC(N)=O)C(=O)N[C@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](CC(=O)O)C(=O)O[C@@H]1Cnon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
764763nanCOC(=O)C[C@@H]1C/C=C\C(=O)O[C@H]([C@H](C)[C@@H](OC)/C(C)=C/C=C/C(C)=C/c2coc(C)n2)C[C@H](O)[C@@]2(C)O[C@@H]2/C=C\[C@@H](C)[C@H](O)C1standard_macrolactone16.0success8.0[3, 5, 6, 6, 7, 10, 11, 13]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.634444
765764nanCC(/C=C/C=C(\C)[C@H](O)[C@@H](C)[C@H]1C[C@H](O)[C@]2(C)O[C@H]2/C=C\[C@@H](C)[C@H](O)C[C@H](CC(=O)O)C/C=C\C(=O)O1)=C\c1coc(C)n1standard_macrolactone16.0success8.0[3, 5, 6, 6, 7, 10, 11, 13]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.678828
766765nanC/C(=C\c1cc(C)ccn1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1standard_macrolactone16.0success11.0[3, 5, 6, 6, 10, 11, 12, 13, 14, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.732185
767766nanCC[C@H]1/C=C\[C@@H]([C@@H](O)C=C(C)C)OC(=O)/C(C)=C\[C@@H]2C(=O)NC3=CC(=O)c4c(cc(C)c(O)c4C(=O)CC1)[C@@]32Ostandard_macrolactone16.0failednon-ring atom 0 marked aromaticring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.752940
768767nanCO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)C(CC=O)C[C@@H](C)[C@@H](O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@H]1Ostandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.799699
769768nanCCOC(=O)c1ccc(OCC[C@H]2C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]2O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)cc1standard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.852788
770769nanO=C1CCCCCCCCCCC(=NOCc2c(F)cccc2Cl)CCCO1standard_macrolactone16.0success1.0[6]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.876405
771770nanCC1CCC(NS(C)(=O)=O)CCCCCCCCCCC(=O)O1standard_macrolactone16.0success2.0[3, 6]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.902265
772771nanC[C@@H]1NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)/C=C/C=C/C=C/C=C/C=C/C(=O)NC2=C(O)CCC2=O)COC(=O)[C@@H]2CCCN2C1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
773772nanCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCCCCCc4ccccc4)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)Ostandard_macrolactone16.0success9.0[3, 5, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:52.963765
774773nanCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](OC3[C@H](CC=O)C[C@@H](C)[C@@H](O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@@H](OC(=O)CC)[C@@H]3OC)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)Ostandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.008784
775774nanCO[C@@H]1[C@@H](OC[C@H]2[C@@H]3O[C@@H]3/C=C\C(=O)[C@](C)(O)CC[C@@H](O[C@H]3O[C@@H](C)C[C@@H](OC)[C@@H]3O)[C@H](C)/C=C\C(=O)O[C@@H]2C)O[C@@H](C)[C@H](O)[C@H]1OCstandard_macrolactone16.0success9.0[3, 4, 5, 6, 9, 10, 10, 13, 14]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.058016
776775nanCC(=O)CC1CCC(=O)CCC(=O)OC(CC(C)=O)CCC(=O)CCC(=O)O1non_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
777776nanO=C1CCCCCCCCCC/C(=N/OC(=O)COc2ccc(Br)cc2Cl)CCCO1standard_macrolactone16.0success1.0[6]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.085179
778777nanCC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCNCC(C)(C)CO)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1Cstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.134989
779778CHEMBL406149CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](n2cccc2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
780779nanCO[C@@H]1[C@@H](OC2OC(C)C(OC3CC(C)(O)C(OC(=O)CC(C)C)C(C)O3)C(N(C)C)C2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=Ostandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.186475
781780CHEMBL313330COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)C3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Clnon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
782781nanCC1CCC(=NOC(=O)C(C)Oc2ccc(Cl)cc2)CCCCCCCCCCC(=O)O1standard_macrolactone16.0success2.0[3, 6]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.219488
783782nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@@H]2O)[C@@H](CC(=O)O)C[C@@H](C)C(=O)/C=C\[C@]2(C)O[C@H]2[C@@H]1Cstandard_macrolactone16.0success11.0[3, 4, 5, 6, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.278453
784783nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC(=O)Nc1ccccc1standard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.331010
785784nanCCC[C@H]1C[C@@H]2CC[C@@H](O2)[C@H](CC)C(=O)O[C@@H]([C@H](CC)[C@H]2CC[C@@H](C[C@@H](CCC)N(C)C)O2)[C@H](C)[C@@H]2CC[C@@H](O2)[C@@H](CC)C(=O)O1non_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
786785nanCOc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(Br)C#Cc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1non_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
787786nanCc1nc2c([nH]1)CCCCCCCCC[C@@H](C)OC(=O)/C=C/2standard_macrolactone16.0failednon-ring atom 1 marked aromaticring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.363557
788787CHEMBL251118C[C@@]1(N)Cc2cccc(c2)CC[C@H](c2ccccc2)NC(=O)c2cc(Br)cc(c2)COC1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
789788CHEMBL350017COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)C[C@@H](C)NC2=O)cc1Clnon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
790789CHEMBL3808853CC1COC(=O)Nc2cccc(c2)CNC(=O)C(Nc2ccc3c(N)nccc3c2)c2ccc1cc2non_standard_macrocycle16.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
791790nanCCCC/C=C/C(=O)N[C@@H](Cc1cccc(F)c1)C(=O)N[C@@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@@H]2CC(C)CCN2C(=O)[C@@H]2CCCN2C1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
792791nanC[C@@H]1CCCCCCCCC[C@H](OC(=O)CCC(=O)O)C(=O)/C=C\C(=O)O1standard_macrolactone16.0success3.0[3, 13, 14]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.419742
793792nanCOC(/C(C)=C/C=C/C(C)=C/c1coc(C)n1)C(C)C1CC(O)C2(C)OC2C=CC(C)C2CC(CC(=O)O2)CC2OC2C(=O)O1standard_macrolactone16.0success10.0[3, 5, 6, 6, 7, 10, 11, 13, 15, 16]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.471826
794793nanCO[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)/C=C\C(=O)O[C@H](C)[C@@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)/C=C\CCC(=O)[C@H](C)C[C@@H]2C)[C@@H]1Ostandard_macrolactone16.0success7.0[3, 4, 9, 10, 12, 13, 14]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.515892
795794CHEMBL3939509CCS(=O)(=O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1ccc3c(N)ncc(F)c3c1)c1ccc(c(C)c1)[C@@H](C)COC(=O)N2non_standard_macrocycle16.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
796795nanCC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCNC2C(O)CCCC2O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1Cstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.572889
797796nanCC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@@H]2O)[C@H](C)C[C@@H](C)C(=O)/C=C\[C@H]2O[C@@H]2[C@@H]1CO[C@@H]1O[C@H](C)[C@H](O)[C@H](OC)[C@H]1OCstandard_macrolactone16.0success9.0[3, 4, 5, 6, 9, 10, 12, 13, 14]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.625955
798797nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COCstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.679071
799798CHEMBL4077853CCS(=O)(=O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1ccc3cc[nH]c(=O)c3c1)c1ccc(cc1)CCOC(=O)N2non_standard_macrocycle16.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
800799nanCC[C@@H]1OC(=O)CCC/C=C\C/C=C\C/C=C\[C@H]2[C@H]1C[C@@H](Cl)[C@@H]2Ostandard_macrolactone16.0success3.0[3, 4, 5]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.715831
801800CHEMBL3349528COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1non_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
802801nanCOc1ccc(C[C@H]2NC(=O)/C=C\C[C@@H](C/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Clnon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
803802nanC=C1Oc2cc(OC)cc(C(=O)O[C@H]3COC(=O)C[C@H](N)c4cc(O)c(c(Cl)c4)O[C@@H]4C#C/C=C/3C#CC3=CC=C[C@@]34O[C@@H]3OC(C)(C)[C@@H](N(C)C)[C@@H](O)[C@H]3O)c2NC1=Onon_standard_macrocycle16.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
804803nanCO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](C(=O)OCNC(=O)OCC3c4ccccc4-c4ccccc43)[C@H](C)[C@@H](C(C)C)O2)OC1=Ostandard_macrolactone16.0success8.0[3, 4, 8, 10, 11, 12, 14, 16]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.784867
805804nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=N/OCCOc2ccccc2)/C=C/C(C)=C/C1COstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.834997
806805nanCO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O[C@@H]2CC[C@H](N(C)C)[C@@H](C)O2)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1Ostandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.880817
807806nanC[C@H]1CCC(=O)/C=C\C(=O)O[C@H](C)CCC(=O)/C=C\C(=O)O1non_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
808807CHEMBL328224C/C1=C/C[C@@H](c2ccc3cccnc3c2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC1standard_macrolactone16.0success9.0[3, 6, 10, 11, 12, 13, 14, 14, 15]ring_size_16/standard/numbered/CHEMBL328224_numbered.png2026-03-19 02:40:53.932537
809808nanCC[C@@H]1OC(=O)/C=C\[C@H](C)[C@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@H](C)C(=O)/C=C\C=C/[C@@H]1CO[C@@H]1O[C@@H](C)[C@H](O)[C@H](O)[C@@H]1Ostandard_macrolactone16.0success7.0[3, 4, 9, 10, 12, 13, 14]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:53.976193
810809CHEMBL3956442CC[C@@H](C(=O)O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1ccc3c(N)ncc(F)c3c1)c1ccc(c(C)c1)[C@@H](C)COC(=O)N2non_standard_macrocycle16.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
811810CHEMBL124364COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccccc3)OC(=O)[C@H](CC(C)C)NC(=O)C3(CC3)CNC2=O)cc1Clnon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
812811nanCO[C@@H]1/C=C\C=C(\C)C[C@H](C)[C@H](O)[C@H](C)/C=C(C)\C=C(\C)C(=O)O[C@H]1/C(C)=C/[C@H](C)C1=CC=C(C)[C@H](C(C)C)O1standard_macrolactone16.0success8.0[3, 4, 8, 10, 11, 12, 14, 16]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:54.033146
813812nanO=C1CCCCCCCCCCC2(CCCO1)N=N/C(=N/c1ccc(Br)cc1)S2standard_macrolactone16.0success2.0[6, 6]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:54.059450
814813CHEMBL3917434CCN(CC)C(=O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1ccc3c(N)nccc3c1)c1ccc(c(C)c1)[C@@H](C)COC(=O)N2non_standard_macrocycle16.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
815814nanCOc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccc(CN4CCNCC4)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Clnon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
816815CHEMBL3967204Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(C3(c4nnn[nH]4)CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)ncc(F)c2c1non_standard_macrocycle16.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
817816CHEMBL327295COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccc(C)c(C)c3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Clnon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
818817nanCC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@]5([C@H](C)O)OCC[C@]6(O[C@H]6C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)[C@H]5Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
819818CHEMBL3251868CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(=O)CCC)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)Ostandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/CHEMBL3251868_numbered.png2026-03-19 02:40:54.136636
820819nanCC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)CC[C@@H](C)C(=O)/C=C\[C@H]2O[C@@H]2[C@]1(O)CO[C@H]1O[C@@H](C)[C@H](O)[C@@H](OC)[C@@H]1OCstandard_macrolactone16.0success9.0[3, 4, 4, 5, 6, 9, 10, 13, 14]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:54.186320
821820nanCC[C@H](C)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@@H](C(C)C)NC(=O)C[C@H](/C=C/c2ccccc2)OC(=O)[C@@H](C(C)C)NC1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
822821nanC/C=C(\NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCN1C(=O)/C(=C/C)NC(=O)CC(O)CCCCC)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCO)C(=O)N[C@H](CCN)C(=O)N[C@@H](CCCCN)C(=O)O[C@@H]1Cnon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
823822nanC/C=C(\NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCN1C(=O)/C(=C/C)NC(=O)CC(O)CCCCC)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCO)C(=O)N[C@H](CCN)C(=O)N[C@@H](CCCCN)C(=O)O[C@@H]1Cnon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
824823nanCCC(=O)O[C@H]1[C@@H](C)O[C@@H](O[C@H]2[C@@H](N(C)C)C[C@H](O[C@@H]3[C@H](CC=O)C[C@H](C)[C@H](O)/C=C\[C@@H]4O[C@H]4C[C@@H](C)OC(=O)C[C@H](OC(C)=O)[C@@H]3OC)O[C@@H]2C)C[C@]1(C)Ostandard_macrolactone16.0success9.0[3, 5, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:54.281429
825824nanC/C=C1\NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)C=C(C)C)C(C)C)[C@@H](C)OC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(=O)O)NC1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
826825CHEMBL3251862CCC(=O)O[C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](OC(C)=O)[C@H](OC)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@H]1Cstandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/CHEMBL3251862_numbered.png2026-03-19 02:40:54.336366
827826nanCCCCCCCCCCCC[C@@H]1CCCCCCCCC(=O)OC[C@H]2O[C@@H](O1)[C@H](OC(C)=O)[C@@H](O)[C@@H]2Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
828827nanCCOC(=O)NN(CC[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](CO[C@@H]2O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]2OC)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]1O)C(=O)OCCstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:54.395466
829828nanCO/C1=C\C(C)=C\[C@@H](C)C(=O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)CC(=O)[C@H](C)[C@@H](C(C)C)O2)OC1=Ostandard_macrolactone16.0success8.0[3, 4, 8, 10, 11, 12, 14, 16]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:54.441607
830829nanCC(Oc1ccc(Cl)cc1Cl)C(=O)ON=C1CCCCCCCCCCC(=O)OCCC1standard_macrolactone16.0success1.0[6]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:54.463920
831830nanCO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)/C=C(\C)C2=C[C@@H](OC)[C@H](C)[C@@H](C(C)C)O2)OC1=Ostandard_macrolactone16.0success8.0[3, 4, 8, 10, 11, 12, 14, 16]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:54.509552
832831CHEMBL3977297Cc1cc2ccc1[C@@H](C)COC(=O)Nc1cc(F)c(O[C@@H](C)CO)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1non_standard_macrocycle16.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
833832nanCOCCOCCC(=O)NCCCC[C@H]1C(=O)C(C)(C)[C@@H](O)CC(=O)O[C@H](/C(C)=C/c2csc(C)n2)C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@@H]1Ostandard_macrolactone16.0success11.0[3, 5, 6, 6, 10, 11, 12, 13, 14, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:54.571060
834833nanC/C(=C\c1csc(C)n1)[C@@H]1C[C@H](O)[C@@](C)(O)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)C(O)CC(=O)O1standard_macrolactone16.0success11.0[3, 5, 6, 6, 10, 11, 12, 13, 14, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:54.625019
835834nanCO[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)/C=C/C(=O)O[C@H](C)[C@@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)[C@@H]3O[C@H]3/C=C/C(=O)[C@@](C)(O)C[C@@H]2C)[C@@H]1Ostandard_macrolactone16.0success10.0[3, 4, 5, 6, 9, 10, 10, 12, 13, 14]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:54.679034
836835CHEMBL2323287CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)-c2nnnn2CC(=O)N[C@@H](C(C)C)C(=O)O1non_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
837836nanCO[C@@H]1C[C@H](OC(N)=O)[C@@H]2C=C[C@@H]3/C=C(C)\C=C/[C@@H](C)[C@H]([C@H](C)[C@H](O)[C@@H](C)NC(C)=O)OC(=O)/C=C\C=C(C)/C=C\[C@]3(C)[C@@H]2C1standard_macrolactone16.0success7.0[3, 4, 7, 9, 10, 10, 13]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:54.729493
838837nanC/C=C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H]2OC)C[C@@H](OC(=O)/C=C/C(=O)NC2=C(O)CCC2=O)[C@@H]1Cstandard_macrolactone16.0success8.0[3, 4, 8, 10, 11, 12, 14, 16]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:54.778292
839838CHEMBL61164CC1C/C=C\CCCCCCCCCOC(=O)N1CC(O)C(Cc1ccccc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@@H]12non_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
840839nanCCC[C@H]1CCCC(=O)N[C@@H](CO)CCC[C@H](C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)O1non_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
841840nanCO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(OC)C[C@@H](C(=O)Oc3ccccc3)[C@H](C)[C@@H](C(C)C)O2)OC1=Ostandard_macrolactone16.0success8.0[3, 4, 8, 10, 11, 12, 14, 16]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:54.838528
842841nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCO)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1OCstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:54.891777
843842nanO=C1CCCCCCCCCCC(NS(=O)(=O)Cc2ccccc2)CCCO1standard_macrolactone16.0success1.0[6]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:54.914916
844843nanCCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/C(=O)[C@H](C)C[C@H](CC=O)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](N(C)C)[C@@H]2O)[C@@H]1OCstandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:54.959222
845844nanCC[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](C)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](N(C)C)[C@H]1Ostandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:55.010411
846845nanCO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)CC(=O)[C@H](C)[C@@H](C(C)C)O2)OC1=Ostandard_macrolactone16.0success8.0[3, 4, 8, 10, 11, 12, 14, 16]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:55.057729
847846CHEMBL3426551CO[C@H]1/C=C(/C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O[C@@H]1/C(C)=C/c1csc(C)n1standard_macrolactone16.0success10.0[3, 4, 6, 10, 11, 12, 13, 14, 14, 15]ring_size_16/standard/numbered/CHEMBL3426551_numbered.png2026-03-19 02:40:55.109211
848847nanO=C1CCCCCCCCCCC(=NOC(=O)COc2ccc(Cl)cc2Cl)CCCO1standard_macrolactone16.0success1.0[6]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:55.133258
849848nanCC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2OC(C)=O)[C@@H](CCOc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OCstandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:55.193169
850849nanC[C@H]1C[C@H](C)[C@H](O[C@@H]2O[C@H](C)C[C@](O)([C@H](C)O)[C@H]2O)[C@@H](C)/C=C\C(=O)O[C@H](C)[C@@H](C)/C=C\C=C/C1=Ostandard_macrolactone16.0success7.0[3, 4, 9, 10, 12, 13, 14]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:55.235203
851850CHEMBL100279COc1ccc(/C=C/[C@@H](C)[C@@H]2C/C=C/C(=O)N[C@H](Cc3ccc(OC)c(Cl)c3)C(=O)NCC(C)(C)C(=O)O[C@@H](CC(C)C)C(=O)O2)cc1non_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
852851nanC[C@H]1CC[C@@H](O)/C=C\C(=O)O[C@@H](C)CC[C@@H](O)/C=C\C(=O)O1non_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
853852nanCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@H](CC=O)C[C@@H](C)[C@@H](OC(C)=O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@@H](OC(=O)CC)[C@@H]3OC)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(C)=Ostandard_macrolactone16.0success7.0[3, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:55.292462
854853nanCOC(=O)[C@H]1[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC)[C@H](C)[C@@H](C(C)C)O2)OC(=O)/C(OC)=C/C(C)=C/[C@H]1Cstandard_macrolactone16.0success8.0[3, 4, 8, 10, 11, 12, 14, 16]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:55.339003
855854CHEMBL3628320CCCCCCCCSSCC/C=C/[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N[C@H](C)C(=O)N[C@H](C(C)C)C(=O)NCC(=O)O1non_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
856855nanCC[C@H]1C[C@@H](C)C(=O)/C=C\C(C)=C/[C@H](C)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@H]1O[C@H](C)[C@H](O)[C@H](O)[C@@H]1Ostandard_macrolactone16.0success9.0[3, 4, 6, 9, 10, 12, 13, 14, 15]ring_size_16/standard/numbered/nan_numbered.png2026-03-19 02:40:55.393789
857856nanC/C=C1\NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](C)C[C@@H](C)CCC)[C@H](C)OC1=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
858857CHEMBL394224CN(c1cc2cc(n1)N(CC1CC1)CCCCc1cccc(c1)C[C@@](C)(N)C(=O)OC2)S(C)(=O)=Onon_standard_macrocycle16.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
859858nanCCCCCCCC(=O)OCC/C=C/[C@H](Cl)[C@H](O)[C@@H]1OC(=O)/C=C\C=C/c2nc(oc2C)/C=C(/C)CC[C@H]2O[C@H]2[C@H]1OC(=O)NC(C)=Onon_standard_macrocycle17.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
860859nanCC(C)C[C@@H]1NC(=O)OC(CCCc2ccccc2)CCCCCNC(=O)CC[C@@H](C(O)S(=O)(=O)O)NC1=Onon_standard_macrocycle17.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
861860CHEMBL4097169CC(C)C[C@@H]1NC(=O)OC(c2cccc(Cl)c2)CCCCCNC(=O)CC[C@@H](C=O)NC1=Onon_standard_macrocycle17.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
862861nanCCNC1CC2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C(CO)=C(/C)CCc4ccnc6c4CCC(NC)N6)C5=O)C(=O)OCC1CC23standard_macrolactone17.0failednon-ring atom 0 marked aromaticring_size_17/standard/numbered/nan_numbered.png2026-03-19 02:40:55.446185
863862nanO=C1O[C@@H]2[C@@H](COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c4oc(=O)c5c(ccc6oc(=O)c3c4c65)-c3c1cc(O)c(O)c3O)O[C@@H](O)[C@H](O)[C@H]2Onon_standard_macrocycle17.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
864863nanCCCCCCCC(=O)OCC/C=C/[C@H]1O[C@H]1[C@H]1OC(=O)/C=C\C=C/C(=O)NC(=O)/C=C(/C)CC[C@@H]2O[C@@H]2[C@@H]1OC(=O)NC(C)=Onon_standard_macrocycle17.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
865864nanCOc1c(OC(C)C)cc2cc(O)c(C(=O)NC3Cc4ccc(c(Cl)n4)O[C@@H]4C=C5C#C/C(=C\C#CC6OC56C4OC4CC(C)(O)C(O)C(C)O4)C(OC4CC(O)C(N(C)C)C(C)O4)COC3=O)cc2c1OCnon_standard_macrocycle17.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
866865nanCCNC1C=C2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C(CO)=C(/C)CCc4ccnc6c4CCC(NC)N6)C5=O)C(=O)OC(CCCO)C1CC23standard_macrolactone17.0failednon-ring atom 0 marked aromaticring_size_17/standard/numbered/nan_numbered.png2026-03-19 02:40:55.490524
867866CHEMBL3628304CC(C)[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)N[C@H](C(C)C)c1cn(nn1)CC(=O)O2non_standard_macrocycle17.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
868867nanCCCCCCCC(=O)OCC/C=C/[C@@H](O)[C@@H](O)[C@H]1OC(=O)/C=C\C=C/[C@@](OC)(C(C)=O)NC(=O)/C=C(/C)CC[C@H]2O[C@@H]2[C@@H]1OC(=O)NC(C)=Onon_standard_macrocycle17.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
869868nanC#CCCC[C@@H]1OC(=O)CCNC(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)C1(C)Cnon_standard_macrocycle17.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
870869CHEMBL2323285CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)-c2nnn(n2)CC(=O)N[C@@H](C(C)C)C(=O)O1non_standard_macrocycle17.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
871870nanCCCC(=O)N[C@@H](CC(C)C)[C@@H](CC(=O)O[C@@H]1COC(=O)c2csc(n2)[C@H](C(C)C)OC(=O)[C@@H](C)[C@H](CCCC(C)(Cl)Cl)OC(=O)c2csc1n2)OC(C)=Onon_standard_macrocycle17.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
872871nanCS[C@H]1SC[C@H](N(C)C(=O)[C@H](C)NC(=O)[C@@H](CO)NC(=O)c2cnc3ccccc3n2)C(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@@H](NC(=O)c2cnc3ccccc3n2)C(=O)N[C@@H](C)C(=O)N(C)[C@@H]1C(=O)N(C)[C@H](C(=O)O)C(C)Cnon_standard_macrocycle17.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
873872nanCC[C@H]1/C=C\[C@@H](O)[C@@H](C)OC(=O)/C(C)=C\[C@H]2C(=O)NC3=CC(=O)c4c(cc(C)c(O)c4C(=O)CC1)[C@]32Ostandard_macrolactone17.0failednon-ring atom 0 marked aromaticring_size_17/standard/numbered/nan_numbered.png2026-03-19 02:40:55.554841
874873nanCC[C@H]1/C=C\[C@@H](O)[C@@H](C)OC(=O)/C(C)=C\[C@@H]2C(=O)NC3=CC(=O)c4c(cc(C)c(O)c4C(=O)CC1)[C@]32Ostandard_macrolactone17.0failednon-ring atom 0 marked aromaticring_size_17/standard/numbered/nan_numbered.png2026-03-19 02:40:55.576589
875874nanC/C=C(C)/C=C(\C)C(O)C(C)[C@H](O)[C@@H](O)[C@H]1C/C=C\C=C\[C@H](O)C[C@@H](O)[C@H](C)c2nc(cs2)/C=C(\CCCCCC)C(=O)O1non_standard_macrocycle17.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
876875CHEMBL2323289CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)-c2cn(nn2)CC(=O)N[C@@H](C(C)C)C(=O)O1non_standard_macrocycle17.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
877876nanCCNC1C=C2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C(CO)=C(/C)CCc4ccnc6c4CCC(NC)N6)C5=O)C(=O)OCC1CC23standard_macrolactone17.0failednon-ring atom 0 marked aromaticring_size_17/standard/numbered/nan_numbered.png2026-03-19 02:40:55.612018
878877nanCC(O)C1/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5O[C@]5(C)CC[C@]4(COC(=O)C4OC4(C)C(O)CO1)[C@]2(C)C31CO1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
879878nanCC(C)[C@@H]1OC(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C1=Onon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
880879nanCC(=O)O[C@H]1CC(=O)OCC2=C3C[C@H]4[C@](O)(COC(=O)/C(C)=C\COC1=O)[C@H]1C[C@H]1[C@]4(C)[C@@H]1C[C@@]4(O)C5=C(C6=C(C)C(=O)O[C@]6(O)C(=O)[C@@]5(C)[C@@H]5C[C@@H]54)[C@]31OC2=Onon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
881880nanC/C1=C/C(C)CC(C)OC(=O)C(C)NC(=O)C(Cc2ccc(O)c(I)c2)N(C)C(=O)CNC(=O)C(C)C1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
882881nanCC(C)C[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C(C)C)C(=O)N1Cnon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
883882nanCC(=O)O[C@@]1(C)CC(=O)OC[C@]23CCC(C)=C[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C/[C@@H]([C@H](C)O)OC[C@H]1O)[C@@]3(C)[C@]21CO1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
884883nanCC1=C2[C@@H]3[C@]45OC(=O)C6=C4C[C@H]4[C@](O)(COC(=O)/C=C(/C)COC(=O)CCC(=O)OC6)[C@H]6C[C@H]6[C@]4(C)[C@@H]5C=C4[C@H]5C[C@H]5[C@](C)(C(=O)[C@@]2(O)OC1=O)[C@@]43Onon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
885884nanC/C1=C/Cc2ccc([nH]2)C2=N[C@@H](/C=C3C(=C(\C)CCCO)/CO[C@H]/3CC(C)C)[C@@H](COC(=O)[C@@H](CC(C)C)CC(=O)O[C@@H]3[C@@H]1OC(=O)[C@]3(C)CO)O2non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
886885nanCOc1ccc2cc1C(=O)OC[C@H]1O[C@H](Oc3cc4c(c(OC)c3C)C(=O)C[C@H](O4)c3ccc(OC)c-2c3)[C@H](OC)[C@H](OC)[C@H]1OCnon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
887886nanC/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
888887CHEMBL578929CC1CC(C)CC(C)C(O)C(C#N)=CC=CCC(C2CCCC2C(=O)O)OC(=O)CC(O)C(C)C1standard_macrolactone18.0success8.0[3, 8, 9, 10, 12, 14, 16, 17]ring_size_18/standard/numbered/CHEMBL578929_numbered.png2026-03-19 02:40:55.724530
889888nanC[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)OCc2cn(-c3cnc4ccccc4c3)nn2)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1standard_macrolactone18.0success8.0[3, 8, 9, 10, 12, 14, 16, 17]ring_size_18/standard/numbered/nan_numbered.png2026-03-19 02:40:55.770342
890889nanC=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@H](/C=C/[C@@H]3CC(C)=CCO3)O[Si](C)(C)C(C)(C)C)C[C@@H]3O[C@H]3[C@@H](O)C1)O2non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
891890nanCC(C)/C=C/C=C/C[C@@H]1NC(=O)[C@H]2C[C@@H](O)CNN2C(=O)COC(=O)[C@](C)(CO)NC(=O)[C@H]2C[C@H](O)CNN2C(=O)[C@H]2C[C@H](Cl)CNN2C1=Onon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
892891nanC=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@@H]3CC(C)=CC(=O)O3)C[C@@H]3O[C@H]3[C@@H](O)C1)O2non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
893892nanC[C@@H]1CCCCCCCCCC[C@H](O)[C@@H](O)[C@@H](O)/C=C\C(=O)O1standard_macrolactone18.0success4.0[3, 14, 15, 16]ring_size_18/standard/numbered/nan_numbered.png2026-03-19 02:40:55.821415
894893nanC[C@@H]1CCCCCCCCCC[C@H](O)[C@@H](O)[C@@H](O)CCC(=O)O1standard_macrolactone18.0success4.0[3, 14, 15, 16]ring_size_18/standard/numbered/nan_numbered.png2026-03-19 02:40:55.852450
895894CHEMBL221540C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@H](C)[C@H](C)C(=O)O)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1standard_macrolactone18.0success8.0[3, 8, 9, 10, 12, 14, 16, 17]ring_size_18/standard/numbered/CHEMBL221540_numbered.png2026-03-19 02:40:55.896530
896895nanC[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(N)=O)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1standard_macrolactone18.0success8.0[3, 8, 9, 10, 12, 14, 16, 17]ring_size_18/standard/numbered/nan_numbered.png2026-03-19 02:40:55.941839
897896nanCCC(C)C1C(=O)OC(C(C)C)C(=O)N(C)C(C(C)CC)C(=O)OC(C(C)C)C(=O)N(C)C(C(C)CC)C(=O)OC(C(C)C)C(=O)N1Cnon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
898897CHEMBL4095773CC1=C2C3=C4[C@](O)(C[C@H]5[C@@]6(C)[C@@H]7C[C@@H]7[C@@]7(O)COC(=O)/C=C(\C)COC(=O)CCC(=O)OCC8=C(C[C@@H]76)[C@@]35OC8=O)[C@H]3C[C@H]3[C@]4(C)[C@@H](O)[C@@]2(O)OC1=Onon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
899898CHEMBL1611678CO[C@@H]1COC(=O)[C@H]2CCCN2C(=O)[C@@H](C)COC(=O)[C@H](COCc2ccccc2)NC(=O)C/C=C\[C@H]1Cnon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
900899nanC[C@@H]1CCOC(=O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H](Br)[C@](C)(O)CC[C@]4(COC(=O)[C@H]1O)[C@]2(C)[C@]31CO1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
901900nanCC1=CC2OC3CC4OC(=O)/C=C\C=C\C(=O)OCCC(C)C(O)C(=O)OCC2(CC1O)C4(C)C31CO1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
902901CHEMBL2206980C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(OCc4ncn(C)n4)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
903902CHEMBL2206969C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(NC)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
904903nanC=C1C[C@@H](CCC)OC(=O)[C@@H](C)CCCC[C@@H]2O[C@@H](CC(=O)[C@@H](O)[C@H](C)C1)C[C@@H]2Cnon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
905904nanCC1=C2C3=C4[C@](O)(C[C@H]5[C@@]6(C)[C@@H]7C[C@@H]7[C@@]7(O)COC(=O)/C(C)=C\COC(=O)CCC(=O)OCC8=C(C[C@@H]76)[C@@]35OC8=O)[C@H]3C[C@H]3[C@]4(C)[C@@H](O)[C@@]2(O)OC1=Onon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
906905nanCC1=C2C3=C4[C@](O)(C[C@H]5[C@@]6(C)[C@@H]7C[C@@H]7[C@@]7(O)COC(=O)/C(C)=C/COC(=O)CCC(=O)OCC8=C(C[C@@H]76)[C@@]35OC8=O)[C@H]3C[C@H]3[C@]4(C)[C@@H](O)[C@]2(O)OC1=Onon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
907906CHEMBL1672606C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCc1cc3c(nccc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
908907nanCC(C)CCCCCCCCCCCC[C@@H]1O[C@H]2O[C@@H](COC(=O)[C@H](C)[C@@H](CCCCCCCCCCCC(C)C)O[C@@H]3O[C@H](COC(=O)[C@H]1C)[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@@H](O)[C@@H]2Onon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
909908nanC/C=C(C)/C=C(\C)C[C@H](C)[C@H](O)[C@@H]1OC(=O)/C(C)=C\c2csc(n2)[C@@H](CO)[C@@H](O)C[C@H](O)/C=C\C=C/C[C@H]1Onon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
910909nanCC[C@H](C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)C(=O)O[C@H](C(C)C)C(=O)N1Cnon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
911910nanCC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@](C)(C(=O)[C@H](O)C1=C(C)C3C[C@@](O)([C@H](C)OC(=O)CC/C=C\CCC(=O)N[C@@H](c4ccccc4)[C@@H](O)C(=O)O3)C1(C)C)C2non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
912911nanCC1=C[C@@H]2O[C@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC/C(C)=C\C(=O)OC[C@]2(CC1)[C@@]4(C)[C@]31CO1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
913912CHEMBL4065225CC(C)C[C@@H]1NC(=O)OC(c2cccc(Cl)c2)CCCCCONC(=O)CC[C@@H](C=O)NC1=Onon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
914913nanCC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/C(=O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
915914nanC=C1C[C@H](C)C(=O)[C@@H](O)C[C@H]2C[C@H](C)[C@H](CCCC[C@H](C)C(=O)O[C@H](CCC)C1)O2non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
916915CHEMBL1365512Cc1ccc(S(=O)(=O)N[C@H]2COC(=O)C/C=C/[C@@H](C)[C@H]3C=C[C@H](O)[C@@H](COC(=O)C/C=C/[C@H]2C)O3)cc1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
917916nanCC(C)[C@@H]1OC(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)NC1=Onon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
918917CHEMBL3355648C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)O)C/C=C/C=C(/CN)[C@H](O)[C@@H](C)C[C@H](C)C1standard_macrolactone18.0success8.0[3, 8, 9, 10, 12, 14, 16, 17]ring_size_18/standard/numbered/CHEMBL3355648_numbered.png2026-03-19 02:40:56.126310
919918nanCC[C@H](C)[C@H]1OC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)C(=O)[C@@H](CC(C)C)NC1=Onon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
920919nanC/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccc(O)c(Br)c2)N(C)C(=O)CNC(=O)[C@@H](C)C1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
921920CHEMBL2426331CO[C@@H]1C(=O)O[C@H](C)[C@H](C)/C=C(\C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1ccc(N)cc1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
922921nanCC1CCOC(=O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5O[C@]5(C)CC[C@]4(COC(=O)C1O)[C@]2(C)C31CO1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
923922nanC/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@@H](CC)[C@@H](O)[C@H](C)C/C(C)=C\C=C/[C@H]2OC)C[C@@H](O)[C@@H]1Cstandard_macrolactone18.0success10.0[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]ring_size_18/standard/numbered/nan_numbered.png2026-03-19 02:40:56.205564
924923nanCCCC[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)CC)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](CCCC)C(=O)O[C@H](C(C)C)C(=O)N1Cnon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
925924nanC/C=C/C(=O)O[C@H]1C[C@@]23COC(=O)[C@@H](O)[C@H](C)CCO[C@@H]([C@H](C)O)/C=C\C=C\C(=O)O[C@@H]4C[C@@H](O[C@@H]2C=C1C)[C@@]1(CO1)[C@]43Cnon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
926925nanC=C1C[C@@H](CCC)OC(=O)[C@@H](C)CCCC[C@@H]2O[C@@H](C[C@H](O)C(=O)[C@H](C)C1)C[C@@H]2Cnon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
927926nanC=C1C[C@H]2C/C=C\[C@@H](O)[C@@H](C)/C(C)=C\C(=O)O[C@H](C[C@@H](C)[C@H](C)O)[C@@H](C)C/C=C\[C@@](C)(O)[C@@](O)(C1)O2non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
928927nanC/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](CO)NC(=O)[C@@H](Cc2ccc(O)c(I)c2)N(C)C(=O)CNC(=O)[C@@H](C)C1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
929928nanC=C1C[C@@H](CC[C@H](C)O)OC(=O)[C@@H](C)CCCC[C@@H]2O[C@H](C[C@@H]2C)C[C@@H](O)C(=O)[C@H](C)C1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
930929nanC[C@H]1CC(=O)OC[C@@]23CC[C@@]4(C)O[C@H]4[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OC[C@H]1O)[C@@]3(C)[C@]21CO1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
931930nanCC1=C[C@@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC[C@@]5(C)O[C@@H]5C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
932931nanC=C1C[C@H](C)C[C@@]2(C)CC=C[C@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@H]3CC(C)=CCO3)C[C@@H]3O[C@H]3[C@@H](O)C1)O2non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
933932nanCOC(=O)/C(C)=C1\C(=O)[C@@H](O)[C@@]2(C)C3=C([C@@H](O)[C@@H]4[C@@]5(OC(=O)C6=C5C[C@@H]5[C@@](O)(COC(=O)/C=C(/C)COC(=O)CCC(=O)OC6)[C@@H]6C[C@@H]6[C@]54C)[C@@H]31)[C@@H]1C[C@@H]12non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
934933nanCC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\C(=O)OCC/C(C)=C/C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
935934CHEMBL1672596C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCOCC1)NC(=O)OCCC/C=C/c1ccc3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
936935nanCOC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C(C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C(C)=C\COC(=O)CCC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@H]31)[C@H]1C[C@H]12non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
937936nanCC(C)C[C@H]1C(=O)O[C@H](Cc2ccccc2)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C)C(=O)N1Cnon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
938937nanC=C1C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2ccc(O)c(Cl)c2)C(=O)N[C@@H](C)C(=O)O[C@@H](C)C[C@@H](C)C1=Onon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
939938nanCC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@@H]([C@H](C)O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(CC1)[C@]4(C)[C@@]31CO1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
940939CHEMBL154035C=C1C[C@H](O)/C=C/C[C@@H]([C@@H](O)/C=C/[C@@H]2CC(C)=CCO2)OC(=O)/C=C/C[C@@H]2C=CC[C@@H](C[C@@H](C)C1)O2non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
941940nanCC(C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)O[C@H](C(C)C)C(=O)N1Cnon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
942941nanC=C1C[C@@H]2C/C=C\[C@H](O)[C@H](C)/C(C)=C\C(=O)O[C@H](CC[C@@H](C)[C@H](C)O)[C@@H](C)C/C=C\[C@@](C)(O)[C@](O)(C1)O2non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
943942nanC[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)OCc2cn(C34CC5CC(CC(C5)C3)C4)nn2)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1standard_macrolactone18.0success8.0[3, 8, 9, 10, 12, 14, 16, 17]ring_size_18/standard/numbered/nan_numbered.png2026-03-19 02:40:56.369999
944943nanCC=C[C@H]1O[C@@](O)([C@H](C)C(O)C(C)[C@@H]2OC(=O)C(OC)=CC(C)=C[C@H](C)[C@H](O)[C@H](CC)[C@H](O)C(C)CC(C)=CC=C[C@H]2OC)C[C@@H](O[C@@H]2C[C@H](O)[C@@H](OC(N)=O)[C@H](C)O2)[C@@H]1Cstandard_macrolactone18.0success10.0[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]ring_size_18/standard/numbered/nan_numbered.png2026-03-19 02:40:56.423516
945944CHEMBL1414358CO[C@H]1COC(=O)[C@@H](CCSC)NC(=O)C/C=C\[C@@H](C)COC(=O)[C@@H](OCc2ccccc2)/C=C\[C@@H]1Cnon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
946945CHEMBL398304BEAUVERICIN G2CC[C@H]1OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](CC)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C1=Onon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
947946CHEMBL347678C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@H](/C=C/[C@@H]3CC(C)=CCO3)OC(C)=O)C[C@@H]3O[C@H]3[C@@H](OC(C)=O)C1)O2non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
948947nanCO[C@@]12OC(=O)C(C)=C1C1=C3[C@](O)(C[C@H]4[C@@]5(C)[C@@H]6C[C@@H]6[C@@]6(O)COC(=O)/C=C(/C)COC(=O)CCC(=O)OCC7=C(C[C@@H]65)[C@@]14OC7=O)[C@H]1C[C@H]1[C@]3(C)[C@H]2Onon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
949948nanC=C1[C@@H](OC)C/C=C\[C@@H](O[C@@H]2O[C@H](OC)[C@@H](O)[C@H](OC)[C@H]2O)CC(=O)O[C@@H](/C=C(/C)C/C=C/C)C/C=C\C=C/C[C@H](C)[C@@H]1OOstandard_macrolactone18.0success6.0[3, 10, 11, 12, 13, 17]ring_size_18/standard/numbered/nan_numbered.png2026-03-19 02:40:56.490165
950949nanC/C1=C\C(=O)OC[C@]23CCC(CO)=C[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C\[C@H]([C@@H](C)O)OCC1)[C@@]3(C)[C@]21CO1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
951950nanCC(C)/C=C/C=C/C[C@@H]1NC(=O)[C@H]2C[C@@H](O)CNN2C(=O)COC(=O)[C@](C)(CO)NC(=O)[C@@H]2C[C@H](O)CNN2C(=O)[C@H]2C[C@H](Cl)CNN2C1=Onon_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
952951CHEMBL2206973C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(O)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
953952CHEMBL2206982C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc4nccn4c3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
954953nanCC1=C[C@@H]2O[C@H]3[C@@H](O)[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC/C(C)=C\C(=O)OC[C@]2(CC1)[C@@]4(C)[C@]31CO1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
955954nanC/C1=C\C(=O)OC[C@]23CC[C@]4(C)O[C@H]4[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C\[C@H]4O[C@H](C1)O[C@@H]4C)[C@@]3(C)[C@]21CO1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
956955nanC=C1CCC[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H](CO)C/C=C/[C@@H](O)C1)O2non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
957956nanC/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1non_standard_macrocycle18.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
958957CHEMBL1076535PALMYRAMIDE ACCC[C@H]1OC(=O)[C@H](C(C)C)NC(=O)[C@@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)OC(=O)[C@H](C)OC(=O)C1(C)Cnon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
959958nanC/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
960959nanC=CCCC[C@@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)OC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@@H]1Cnon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
961960nanCC[C@H](C)C[C@H](C)C[C@@H](C)/C=C(\C)[C@@H]1O[C@](O)([C@](C)(O)C(=O)N[C@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)CC(=O)N(C)CC(=O)NCC(=O)N(C)CC(=O)O[C@@H]2C(C)C)CC[C@H]1OCnon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
962961nanCC[C@H](C)[C@]1(C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
963962nanCC[C@H](C)[C@@H]1NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)CNC(=O)CCCC(C)C)[C@H](C)OC(=O)[C@H](C(C)C)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
964963nanCC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1Cnon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
965964nanCC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(OC)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(C)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1Cnon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
966965nanC/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
967966nanCC[C@H](C)[C@@H]1NC(=O)[C@@H]2[C@@H](C)CCN2C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H]([C@@H](C)CC)N(C)C1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
968967nanC=C1C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@@H](c2ccc(O)cc2)CC(=O)O[C@@H](C)C[C@@H](C)C1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
969968nanCC(C)CCCCC(C)(C)CCC[C@@H]1CC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O1non_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
970969nanC/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1non_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
971970nanC/C=C/C1CC2C(=O)OC(C)C(NC(=O)C(CC3CC3[N+](=O)[O-])NC(=O)c3ccc(Cl)n3O)C(=O)NC(C(C)c3ccccc3)C(=O)NC(CC3CC3[N+](=O)[O-])C(=O)NC(C(C)c3ccccc3)C(=O)NC(C(C)CC)C(=O)N2C1non_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
972971nanCC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](O)COS(=O)(=O)O)[C@@H](C)OC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
973972nanCC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](O)Cc2ccc(O)cc2)[C@@H](C)OC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
974973nanC/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
975974nanC/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)[O-])OC)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
976975nanC/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)CCCC(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
977976nanC=CC[C@@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CCCN2C1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
978977CHEMBL2204319C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCC/C=C/c1ccc3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1non_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
979978nanCC(C)[C@@H]1NC(=O)[C@@H]2CSCSC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)c3cnc4ccccc4n3)COC1=O)C(=O)N[C@@H](C(C)C)C(=O)OC[C@@H](NC(=O)c1cnc3ccccc3n1)C(=O)N[C@@H](C)C(=O)N2non_standard_macrocycle19.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
980979nanCCCCCC[C@@H]1CC[C@@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@H]3C(=O)N(O)[C@@H](COC)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)O[C@@H]2C)O[C@H]1Cnon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
981980nanO=C1CCCCCCCCCCC(=O)OCCOCCO1non_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
982981nanCCC[C@H]1NC(=O)c2csc(n2)[C@H](C)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C)OC(=O)[C@@H]1Cnon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
983982nanC/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OCCc3ccc(cc3)Oc3cc(ccc3O)CCOC(=O)C[C@H]21non_standard_macrocycle19.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
984983nanCCC[C@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CCCN2C1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
985984nanCC[C@@H]1NC(=O)[C@@H](C)C/C(C)=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
986985nanCC(C)[C@H]1C(=O)OC[C@@H](NC(=O)c2cnc3ccccc3n2)C(=O)N[C@@H](C)C(=O)N(C)[C@H]2CSCSC[C@@H](C(=O)N1C)N(C)C(=O)[C@H](C)NC(=O)[C@H](NC(=O)c1cnc3ccccc3n1)COC(=O)[C@H](C(C)C)N(C)C2=Onon_standard_macrocycle19.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
987986nanC/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)[C@@H](C)C1non_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
988987nanC/C=C\C=C\C=C/C=C/C=C\C=C/C=C/C=C/C(=O)N(C)[C@@H]1C(=O)N[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)O[C@@H]1Cnon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
989988nanC/C=C1\NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](CCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
990989nanC/C=C1\NC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
991990nanC/C1=C/[C@@H](O)C[C@H](C)CCO[C@@H]2O[C@H](CO[C@@H]3OC[C@](O)(COC1=O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
992991nanCCCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]2CC[C@@H](O)N(C2=O)[C@@H]([C@@H](C)O)C(=O)N(C)[C@@H](Cc2ccc(O)c(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C)[C@@H](C)Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
993992nanCCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCCN(C)C)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1Cnon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
994993nanC/C=C1/[C@H](O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O[C@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3O)[C@@H]2O)OC=C2C(=O)OCCc3ccc(cc3)Oc3cc(ccc3O[C@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3O)CCOC(=O)C[C@@H]21non_standard_macrocycle19.0multiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
995994nanC=CC[C@@H]1/C=C(/C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H]([C@@H](C)[C@H](O)/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)CC1=O)[C@H](C)C[C@@H]2OCnon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
996995CHEMBL1532000CO[C@@H]1COC(=O)[C@H]2CCCN2C(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)CCC[C@H]1Cnon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
997996nanCC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
998997CHEMBL1159823PROTEOLYTIC ENZYME INHIBITORCC(C)C[C@H]1C(=O)N(C)[C@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](O)COS(=O)(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]2CC[C@H](O)N1C2=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
999998nanC/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
1000999nanC/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10011000CHEMBL3823434COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc2ccc3cc(-c4ccc5c(c4)OCCCCCCOC(=O)N[C@@H](C(C)C)C(=O)N4CCC[C@H]4c4ncc-5[nH]4)ccc3c2[nH]1)C(C)Cnon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10021001nanC/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(F)(F)F)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10031002nanCC(C)[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCCCN=C(N)N)[C@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@H](C)O)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10041003CHEMBL402405MICROPEPTIN T2CCCCCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](Cc2ccccc2)C(=O)N(C)[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1Cnon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10051004nanCC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10061005nanC/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)c2ccc(C)cc2)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10071006nanCOc1cc(O)c2c(c1)/C=C/CC(=O)NCCCCNC(=O)CCC[C@H](C)OC2=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10081007nanCC(C)CC1CCC(O)(C(C)(O)C(=O)NC2C(=O)N3NCCCC3C(=O)N(O)C(C)C(=O)N(C)C(Cc3ccccc3)C(=O)N3NCCCC3C(=O)NC(CO)C(=O)OC2C(C)C)OC1Cnon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10091008nanC/C(Br)=C\[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C=C/C(=O)O1non_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10101009nanCO[C@@H]1/C=C\C=C/C[C@H](OC)c2coc(n2)C[C@@H](O)C(C)(C)[C@@H](C[C@H](OC)[C@H](C)CCC(=O)[C@H](C)[C@H](C/C=C/N(C)C=O)OC)OC(=O)C[C@H](O)C1non_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10111010nanCCCCC(C)C1CC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)O1non_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10121011nanC/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10131012nanCO[C@]1(C[C@@H]2C(=O)N[C@@H](c3ccc(O)cc3)CC(=O)O[C@@H](C)C[C@@H](C)/C=C(/C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N2C)OC(=O)Nc2ccccc21non_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10141013CHEMBL396293C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CCCC(C)C)C(C)C)[C@H](C)OC(C)=O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10151014nanCC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCCNC)NC(=O)[C@@H](NC(=O)[C@H](O)COS(=O)(=O)O)[C@@H](C)OC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10161015nanCC[C@H](C)[C@H]1NC(=O)C(Cc2ccc(OC)cc2)NC(=O)[C@@H](NC(=O)[C@@H](NC=O)[C@H](C)CC)[C@@H](C)OC(=O)[C@H](C)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CCCNN2C1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10171016nanCC(C)[C@@H]1OC(=O)[C@@H](C)N(O)C(=O)[C@@H]2CCCNN2C(=O)CNC(=O)[C@H](C)N(O)C(=O)[C@H]2CCCNN2C(=O)[C@H]1NC(=O)[C@@](C)(O)CCCc1ccccc1non_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10181017CHEMBL1076833CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](CO)OS(=O)(=O)O)[C@@H](C)OC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10191018nanC/C=C1\NC(=O)[C@H](CCC2CCCCC2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10201019nanCC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2CC(=O)CCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10211020nanC/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)O)OC)C(C)C)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10221021nanC=C/C=C(\C)[C@H](O)CC[C@@H](C)/C=C/[C@H]1CC[C@H](C)C(=O)CC(=O)N[C@@H](C)CCC(=O)[C@H](C)[C@@H](O)[C@@H](C)/C=C(/C)C(=O)O1non_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10231022CHEMBL256304MICROPEPTIN SD944CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H]([C@@H](C)CC)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1Cnon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10241023CHEMBL1077010MOLASSAMIDEC/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CCC)[C@@H](C)O)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10251024nanCCC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(O)CCl)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10261025nanCCCCCCCC1OC1C(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc2c[nH]c3ccc(O)cc23)C(=O)N[C@@H](c2ccc(O)cc2)C(=O)NCC(=O)O[C@@H]1Cnon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10271026nanC=C1NC(CC(C)C)C(=O)N[C@H](C(C)C)C(=O)N2NCCCC2C(=O)CC(CC(C)C)C(=O)N2NCCCC2C(=O)OC(C)[C@H]1NC(=O)[C@@H](NC=O)[C@@H](C)CCnon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10281027CHEMBL519769MICROPEPTIN 88 ECCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@@H]1C)C(=O)Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10291028CHEMBL1076830CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](O)CO)[C@@H](C)OC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10301029nanCC(C)[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@H](NC(=O)C[C@H](O)CCCCCCCCCCCCNC(=N)N)[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10311030nanC/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1non_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10321031nanC/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](C)C1non_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10331032CHEMBL3577228CCCCCC/C=C\CCC[C@@H]1CC(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O1non_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10341033nanC/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)[O-])OC)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10351034nanCC(=O)O[C@]1(C)CC(=O)OC[C@@H]2CC(C)=C[C@H]3O[C@@H]4C[C@@H](OC(=O)/C=C\C=C/[C@@H]([C@H](C)O)OC[C@@H]1O)[C@](C)([C@@H]32)[C@@]41CO1non_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10361035nanCC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2CC(=O)[C@H](CS[C@@H]3CN4CCC3CC4)CN2C(=O)[C@H](Cc2ccc(N(C)C)cc2)N(C)C(=O)[C@@H]2CCCN2C1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10371036CHEMBL539419ISARIDIN C2CC(C)CC1OC(=O)CCNC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2C(C)CCN2C1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10381037nanC/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)O)OC)C(C)C)[C@@H](C)OC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10391038CHEMBL1783105VERAGUAMIDE ACC[C@H](C)[C@@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@@H](C)[C@@H](CCCC#CBr)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C1=Onon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10401039nanC#CCCC[C@H]1OC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1Cnon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10411040nanC/C1=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@H](Cc2ccc(O)c(Br)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1non_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10421041nanCCCCCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H]2CC[C@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1Cnon_standard_macrocycle19.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10431042CHEMBL605826C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1(C)CCCCC1)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1non_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10441043CHEMBL1524593CO[C@H]1COC(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)[C@@H](C)COC(=O)C/C=C\[C@@H]1Cnon_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10451044nanCCC/C=C/C=C/C(=O)O[C@H]1C2=CC(=O)O[C@@H]2[C@H]2C[C@H](C(C)=O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]4C/C(=C\C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(O)O2)O4)O3non_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10461045nanC=C/C=C\[C@H](C)[C@H](O)[C@@H](C)[C@H]1CC[C@@H](C)C[C@H](C)[C@@H](O)[C@@H](C)/C=C\[C@@H](O)C[C@H](O)[C@H](C)/C=C/C=C\C(=O)O1standard_macrolactone20.0success8.0[3, 6, 8, 9, 10, 13, 15, 16]ring_size_20/standard/numbered/nan_numbered.png2026-03-19 02:40:57.290303
10471046nanCO[C@H]1/C=C\C=C(/C)C(=O)OCc2cn(nn2)C[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)C(=O)O[C@H]1CO[Si](C)(C)C(C)(C)Cnon_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10481047nanCCCC(=O)O[C@H]1C[C@H]2C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@H]3C/C(=C\C(=O)OC)[C@@H](OC(=O)CCC)[C@](O)(O3)C(C)(C)/C=C\[C@H]3C/C(=C\C(=O)OC)C[C@@H](C[C@](O)(O2)C1(C)C)O3non_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10491048nanC=C(C)CC(=O)N/C=C/C(C)=C/[C@@H](C)[C@H]1C/C(C)=C\C=C/CC[C@H](OC(N)=O)[C@@H](O)/C=C\[C@@H](O)CCC/C=C\C(=O)O1standard_macrolactone20.0success5.0[3, 5, 11, 12, 15]ring_size_20/standard/numbered/nan_numbered.png2026-03-19 02:40:57.337729
10501049nanCO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](OC)[C@@H](O)/C=C(C)/C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](OC)C[C@H](OC)[C@]13CO3)O2non_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10511050CHEMBL599873C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC1(CCCCc3cccc4c3CN(C4)C(=O)O2)CCC1)C(=O)NS(=O)(=O)C1CC1non_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10521051nanCCCC(=O)O[C@H]1C[C@H]2C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@@H](OC(C)=O)[C@@](O)(O3)C(C)(C)/C=C\[C@H]3C/C(=C/C(=O)OC)C[C@@H](C[C@](O)(O2)C1(C)C)O3non_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10531052CHEMBL501873CCC[C@H](NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)C(=O)CC1CC1non_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10541053nanCC(C)CC1NC(=O)C(C(C)C)NC(=O)CC(C)COC(=O)C(CC(C)C)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)OC1=Onon_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10551054nanCC[C@@H]1/C=C\[C@H](O)[C@H](C=C(C)C)OC(=O)/C(C)=C\CC(=O)Nc2cc(O)cc3c2O/C(=C\C(=O)CC1)C=C3non_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10561055nanCOC(=O)/C=C1/C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(=O)CC(C)C)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@H](OC(C)=O)[C@@](O)(O3)C(C)(C)/C=C\[C@@H](C1)O2non_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10571056CHEMBL3674588CCCCCCCCCCCC/C=C/c1ccc([C@@H]2C[C@@H]3CCO[C@H](/C=C/C(C)(C)[C@]4(O)O[C@@H](C/C(=C\C(=O)OC)[C@@H]4OC(=O)CCCCCCC)C[C@H](CO)OC(=O)C[C@H](O)CCO2)O3)cc1non_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10581057nanCO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](O)C/C=C(C)/C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](O)C[C@H](OC)[C@@H]1C)O2non_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10591058nanCC[C@H]1/C=C\[C@H](O)[C@H](C=C(C)C)OC(=O)/C(C)=C\CC(=O)Nc2cc(O)cc3c2O/C(=C\C(=O)CC1)C(C)=C3non_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10601059CHEMBL1514135CO[C@@H]1COC(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)[C@H](C)COC(=O)C/C=C\[C@H]1Cnon_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10611060CHEMBL454218IPOMOEASSIN BC/C=C(\C)C(=O)O[C@@H]1[C@@H](O)[C@H]2O[C@H](COC(=O)CCC(=O)CCCCCC[C@H](CCC)O[C@@H]3O[C@H](C)[C@H](O)[C@H](O)[C@H]3O2)[C@H]1OC(=O)/C=C/c1ccccc1non_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10621061nanCCCCC[C@H]1CCCCCCCCCC(=O)OC[C@H]2O[C@@H](O[C@@H]3[C@@H](O)[C@@H](O)[C@@H](C)O[C@H]3O1)[C@H](O[C@@H]1O[C@@H](C)[C@H](OC(=O)[C@@H](C)CC)[C@@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@H]1OC(=O)[C@@H](C)CC)[C@@H](O)[C@@H]2Onon_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10631062CHEMBL527062C=CC1CC1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)P(C)(=O)Onon_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10641063CHEMBL94864O=C1Cn2c(Cl)cnc(c2=O)N[C@@H](Cc2ccccc2)CNC(=O)OC/C=C/COc2ccc(Cl)cc2CN1non_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10651064nanCC(C)C[C@H]1NC(=O)CO[C@@H]2C/C=C\C=C/C=C\C[C@@H](O)[C@@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@](C)(OC(=O)[C@@H]3C[C@@H](CC[C@H]3O)NC(=O)[C@@H](C(C)C)NC1=O)O[C@@H](C)C2non_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10661065CHEMBL1256598CC1(C)CCCCc2cccc3c2CN(C3)C(=O)O[C@@H]2C[C@@H](C(=O)N[C@@H]3BOCC3)N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)OC1non_standard_macrocycle20.0contains_non_carbon_ring_atoms_outside_positions_1_2Ring positions 3..N contain non-carbon atoms.skipped
10671066nanCc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)C[C@H](O)[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3[C@@H](C)C(=O)C[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C)C(=O)O[C@H]2CO)c(N)c1=Onot_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10681067nanCc1ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2c1Oc1c(c(C(=O)N[C@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]3C)c3nc(-c4ccc(Cl)cc4Cl)c(=O)oc3c1C)N2not_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10691068nanCc1c2oc3c(C)cnc(C(=O)NC4C(=O)NC(C(C)C)C(=O)N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)c3nc-2c(C(=O)NC2C(=O)NC(C(C)C)C(=O)N3CCCC3C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC2C)c(N)c1=Onot_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10701069CHEMBL3218172CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N\OCc5cc(OC)c(OC)c(OC)c5)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N/OCc2cc(OC)c(OC)c(OC)c2)[C@H](C)[C@@H](O)[C@]1(C)Onot_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10711070nanCCCCCc1c(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/CCc4cccc(c4)CC4CC(CCC4=O)C3(O)CCC)C2)cc1NCC(C)Onon_standard_macrocyclemultiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
10721071nanCCCCCc1c(CO)cc(C2C#CC3CC(=O)Oc4c3cc(c(O)c4C3C=CC=CC3)CC3OC(=O)/C(=C/C(O)Cc4cccc(c4)CC4CC(CCC4=O)C3(O)CCC)C2)cc1NCC(C)Onon_standard_macrocyclemultiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
10731072nanCOC(=O)C[C@@H]1C(=O)CC[C@H](C)C(=O)O[C@H]2[C@@H](OC(C)=O)[C@]3(COC1=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(=O)[C@](C)(O)[C@H](C)c4ccncc4C(=O)OC[C@]4(C)O[C@@]3([C@H](OC(C)=O)[C@@H]24)[C@@]1(C)Onot_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10741073nanCCCCNc1c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c2nc3c(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)ccc(C)c3oc-2c(C)c1=Onot_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10751074nanCC[C@@H]1OC(=O)C[C@H](O)[C@@H](C)[C@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@H](CCNCC[C@H]2C[C@@H](C)C(=O)/C=C/C(C)=C/C(COC3OC(C)C(O)C(OC)C3OC)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]2OC2OC(C)C(O)C(N(C)C)C2O)C[C@H](C)C(=O)/C=C/C(C)=C/C1COC1OC(C)C(O)C(OC)C1OCnot_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10761075nanCC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/C(O)C4(CCCC4)c4cccc(c4)CC4C(=O)CCC5C4CCCC35O)C2)c1non_standard_macrocyclemultiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
10771076nanCCc1nc2c(C(=O)N[C@@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]3C)c3c(c(C)c2oc1=O)Oc1c(C)ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c1N3not_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10781077nanCCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(CO)cc(NCC(C)(O)CCOC5CCCC5)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5C4CCCCC4)CC1OC3=O)C2non_standard_macrocyclemultiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
10791078nanCOCCC(C)(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/CCc4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)c1non_standard_macrocyclemultiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
10801079nanCCCCCCCCCCCNc1c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c2nc3c(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)ccc(C)c3oc-2c(C)c1=Onot_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10811080nanC[C@H]1CCCCC[C@@H](O)C(=O)[C@H](S[C@@H]2CC(=O)O[C@@H](C)CCCCC[C@@H](O)C2=O)CC(=O)O1not_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10821081nanCc1c2oc3c(C)c(OCC4CN4)cc(C(=O)NC4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)NC2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=Onot_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10831082nanCCN1CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)c2c3c(c(C)c4oc(=O)c(-c5ccccc5)nc24)Oc2c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c2N3)C(=O)N[C@H](C(C)C)C(=O)N2CCC[C@H]2C1=Onot_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10841083nanCc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(NCCCCCCCCCCN)c1=Onot_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10851084CHEMBL4073368Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)C[C@H](O)[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CC(=O)C[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C)C(=O)O[C@@H]2C)c(N)c1=Onot_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10861085CHEMBL2369146Cc1c2oc3c(C)c(OCC4CO4)cc(C(=O)N[C@@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=Onot_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10871086nanCCCC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(CCCC3)C(O)/C=C3\CC(c4cc(CO)cc(NCC(C)O)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5C4C=CC=CC4)CC1OC3=O)C2non_standard_macrocyclemultiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
10881087nanCc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(NCCCCCN)c1=Onot_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10891088CHEMBL2369550CC[C@@H](C)[C@H]1NC(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)c2c3nc4c(C(=O)N[C@@H]5C(=O)N[C@H]([C@H](C)CC)C(=O)N6CCC[C@H]6C(=O)N(C)CC(=O)N[C@H]([C@H](C)CC)C(=O)O[C@@H]5C)ccc(C)c4oc-3c(C)c(=O)c2N)[C@@H](C)OC1=Onot_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10901089nanCCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC/C=C3\CC(c4cc(NCC(C)O)cc(C(O)CNC)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2non_standard_macrocyclemultiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
10911090nanC/C=C1\NC(=O)[C@H]([C@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H]2CC(=O)O[C@H](C(=O)O)[C@H](NC1=O)C(=O)N[C@@H]([C@H](O)CCl)C(=O)OC[C@H](NC(=O)C[C@H](O)CCCCCCCCCCC)C(=O)N[C@H](CCN)C(=O)N2non_standard_macrocyclemultiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
10921091nanCc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H]([C@H](C)O)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=Onot_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10931092nanCc1c2oc3c(C)c(OC(=O)Cc4ccc(Cl)c(Cl)c4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=Onot_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10941093nanCc1c2oc3c(C)c(NCc4ccc(C(F)(F)F)cc4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=Onot_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
10951094nanCC1(O)C2CCC(=O)C(Cc3ccc4c(c3)CC(O)/C(=C3\CC(c5cc(O)cc(CO)c5)C#CC5CC(=O)Oc6cc(O)c(cc65)CC1OC3=O)CC4)C2non_standard_macrocyclemultiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
10961095nanCCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(O)cc(C(O)CNC)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2non_standard_macrocyclemultiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
10971096nanCC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C4\CCc5ccc(cc5CC4)CC4CC(CCC4=O)C3(C)O)C2)c1non_standard_macrocyclemultiple_overlapping_macrocycle_candidatesOverlapping macrolactone candidate rings were detected.skipped
10981097nanCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N\OCc5ccccc5)[C@H](C)C[C@@]4(C)O)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)Onot_macrolactoneclassification_errorMultiple valid macrolactone candidates were detected. Pass ring_size explicitly.skipped
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