id,source_id,molecule_name,smiles,classification,ring_size,primary_reason_code,primary_reason_message,processing_status,error_message,num_sidechains,cleavage_positions,numbered_image_path,processed_at
1,CHEMBL1735765,,C[C@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
2,nan,,O=C(C[C@@H]1C/C=C\C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@@H]2CCCN2C1=O)N[C@@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
3,nan,,C/C=C1\C(OC2OC(CO)C(O)C(O)C2O)OC=C2C(=O)OCC(C)C3CC(OC(=O)CC21)C(C)C3CO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
4,nan,,C[C@@H]1C[C@](O)([C@@H](C)Cl)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
5,nan,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(Oc4c(C(=O)OC[C@H]5O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]5O)cc(O)c(O)c4O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
6,nan,,O=C1NC[C@H](c2ccccc2)OC(=O)[C@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
7,nan,,CO[C@H]1/C=C\CC/C=C\C(=O)O[C@@H](/C(C)=C/[C@H](C)C(=O)/C=C/CC2CC(=O)NC(=O)C2)[C@@H](C)[C@@H]1O,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 5, 6]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.053274
8,nan,,C[C@@H]1COC(=O)[C@@H](CC(=O)OC(C)(C)C)C/C=C\C[C@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
9,nan,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)CCCCCC/C=C/[C@H]1C,standard_macrolactone,12.0,,,success,,2.0,"[3, 4]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.084453
10,nan,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@](C)(O)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.122709
11,nan,,CC[C@]1(O)C[C@@H](C)[C@](C)(OC(C)=O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
12,nan,,CC1CCC(O)CCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,12.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.147647
13,nan,,CC(=O)O[C@H]1/C=C/C[C@@H](/C(C)=C/C=C/CC[C@H]2O[C@@H]2C[C@H](C)O)OC(=O)CCCC[C@@]1(C)O,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 8]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.183707
14,nan,,O=C1O[C@@H](c2ccccc2)C[C@@H](O)C(=O)CCCCc2ccccc21,standard_macrolactone,12.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.204651
15,nan,,CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H](CO)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cc(O)c(Br)cc1Br,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
16,nan,,O=C(Oc1c(O)cc2c(c1O)-c1c(cc(O)c(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](O)[C@H](OC2=O)[C@@H]1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
17,nan,,C/C(=C\[C@@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@H]1OC(=O)/C=C\CC/C=C\C=C/[C@@H]1C,standard_macrolactone,12.0,,,success,,2.0,"[3, 4]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.245607
18,nan,,C=COCOc1cc(O)c2c(c1)CCCCCCC[C@@H](C)OC2=O,standard_macrolactone,12.0,,,failed,non-ring atom 5 marked aromatic,,,ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.263591
19,nan,,C=C1NC(=O)[C@@H](CCCc2ccc(OC)cc2)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C)NC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
20,nan,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC1=O)[C@@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
21,nan,,CC(=O)O[C@@]1(C)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC(=O)[C@@](O)([C@@H](C)O)C[C@H]1C)[C@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
22,nan,,O=C(O)C[C@@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@H]1C(=O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
23,nan,,CC(=O)O[C@@H]1/C=C\C[C@H](/C(C)=C/C=C/[C@@H](C)O)OC(=O)C[C@H](O)CC[C@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 7, 8, 11]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.323166
24,nan,,O=C1OC[C@@H]2O[C@@H](O)[C@H]3OC(=O)c4cc(O)c(O)c5c4[C@@H]4C(=CC(=O)[C@](O)(O5)C4(O)O)C(=O)O[C@H]2[C@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]2C1=CC(=O)[C@](OC(=O)c1cc(O)c(O)c(O)c1)(O3)C2(O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
25,nan,,CC/C=C\C=C/C(=O)N/C=C/C[C@@H]1C[C@H](O)[C@H](C)C/C=C\Cc2cccc(O)c2C(=O)O1,standard_macrolactone,12.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.349246
26,CHEMBL2381165,,CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4ccc(I)c(O)c4)O[C@@]1(C3)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
27,nan,,O=C(C[C@@H]1C/C=C\C[C@H](Cc2ccc(F)cc2)C(=O)OCCNC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
28,nan,,C[C@@H]1CCCCC[C@H](O)C(=O)[C@H](O)CC(=O)O1,standard_macrolactone,12.0,,,success,,4.0,"[3, 9, 10, 11]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.392334
29,nan,,C=C1C/C(=C\C)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@@]1(C)OC(C)=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
30,nan,,C[C@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
31,nan,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](OC(C)=O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.442180
32,nan,,C[C@@H]1CCC[C@@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.460231
33,nan,,O=C(C[C@@H]1C/C=C\CCC(=O)OC[C@H](Cc2ccccc2)NC1=O)N[C@@H](CO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
34,nan,,C/C=C1\C[C@H](C)[C@](C)(O)C(=O)OCC2=CCN3C[C@@H](O)[C@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
35,nan,,C[C@H]1CCC(=O)[C@@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.490508
36,CHEMBL524666,,O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]2C1=CC(=O)C(O)(O)C2(O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
37,nan,,C/C=C1\C(=O)O[C@@H]2CCN3CC[C@H](COC(=O)[C@@](C)(O)[C@H](C)[C@@H]1O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
38,nan,,COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OC[C@H](NC(=O)[C@@H]2CCCN2C(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
39,nan,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)[C@H](C)[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@H]1C,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 8, 11, 12]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.553014
40,nan,,O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@@H](O3)[C@@H](OC(=O)c3cc(O)c(O)c4c3[C@H]3C1=CC(=O)C(O)(O)[C@@]3(O)O4)[C@@H]2OC(=O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
41,CHEMBL1730563,,O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)C/C=C\C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
42,nan,,C/C=C1\C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
43,nan,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CCC[C@@H](O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 4, 7, 11]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.604710
44,nan,,CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@H](OC(=O)[C@@]3(C[C@@H]1C)O[C@@H]3C)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
45,nan,,CC[C@H]1C(=O)O[C@H]2CCNC/C=C(/COC(=O)[C@@](C)(O)[C@H](C)[C@@H]1O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
46,nan,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)NC[C@@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
47,nan,,CC[C@H](O)C[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.667437
48,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)O,standard_macrolactone,12.0,,,success,,8.0,"[3, 4, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.712613
49,nan,,CC[C@H]1CCC[C@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@@H]3[C@@H](C=C[C@@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C[C@@H]34)[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,6.0,"[3, 7, 8, 9, 10, 11]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.756811
50,nan,,O=C(O)C[C@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2c(cc(O)c(O)c2O)[C@H]1[C@H](O)C(=O)O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
51,CHEMBL39858,,CCCCCCC[C@H]1OC(=O)C[C@@H](OCOC)[C@H](Cc2ccccc2)N(C)C(=O)COC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
52,CHEMBL1879879,,C[C@@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
53,CHEMBL39969,,CCCCCCC[C@H]1OC(=O)C[C@@H](OCOC)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C)OC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
54,nan,,CC(=C/C(C)=C/C[C@@H](O)C[C@H](C)O)/C=C(C)\C=C\C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 6, 8, 9]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.817790
55,nan,,CC/C=C\C=C/CC[C@]1(C)C[C@H](O)[C@H](C)CC[C@H]2C[C@@H](C[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]3OC)C[C@@](O)(CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
56,CHEMBL35924,,CCCCCCC[C@@H]1CC(=O)O[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)[C@H](O)CC(=O)O1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
57,nan,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](C(C)C)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,6.0,"[3, 7, 8, 9, 10, 11]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.874630
58,nan,,C[C@@H]1C[C@](O)([C@@H](C)Cl)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
59,nan,,C/C=C1/CC[C@@](C)(OC(C)=O)C(=O)OC[C@@]2(O)CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
60,nan,,COC(=O)[C@H]1OC(=O)c2cc(O)c(O)c(O)c2[C@@H]1[C@H](CC(=O)O)C(=O)O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]1[C@@H](O)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
61,nan,,O=C(Oc1c(O)cc(C(=O)O[C@@H]2O[C@@H]3COC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]([C@H]2O)[C@@H]3O)cc1O)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
62,nan,,C/C=C1/C[C@]2(CO2)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
63,CHEMBL1714949,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
64,nan,,CCOc1cc(O)c2c(c1)CCCCCCC[C@@H](C)OC2=O,standard_macrolactone,12.0,,,failed,non-ring atom 3 marked aromatic,,,ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.937596
65,CHEMBL3260944,,CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)/C(C)=C\CCc3coc(/C=C\CNC(=O)OC)n3)C[C@H](CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
66,nan,,CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@@]3(O)CC(=O)O[C@](C)(CC/C=C/C=C/Br)C[C@@H](O)[C@H](C)CC[C@H](O3)[C@@H]2C)[C@H](O)[C@@H]1OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
67,nan,,CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](C)(O)[C@H]3O[C@@H]3O[C@@H](C)[C@H](O)[C@@](C)(O)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
68,nan,,C=CCOc1cc(O)c2c(c1)CCCCCCC[C@@H](C)OC2=O,standard_macrolactone,12.0,,,failed,non-ring atom 4 marked aromatic,,,ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:31.975893
69,nan,,CO[C@H]1CC(=O)C/C=C\[C@@H](O)CC(=O)O[C@H](C)C1,standard_macrolactone,12.0,,,success,,4.0,"[3, 5, 7, 11]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:32.022132
70,nan,,C/C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
71,nan,,CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:32.066182
72,nan,,C=C[C@H]1[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OCC[C@@H]3C(=CO[C@@H](O[C@H]4O[C@@H](CO)[C@H](OC(=O)/C=C/c5ccc(O)cc5)[C@@H](O)[C@@H]4O)[C@@H]3C=C)C(=O)OCC[C@H]21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
73,nan,,C[C@H]1C[C@H](C)[C@H](O)[C@H](C)C(=O)O[C@H]([C@H](C)O)[C@@H](C)/C=C\C1=O,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:32.113175
74,nan,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3O[C@@](O)(C2)[C@H](C)C(=O)O[C@@H](/C=C/C=C/Br)C/C(C)=C\C(=O)C3(C)C)[C@H](OC)[C@@H]1O[C@@H]1O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]1OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
75,nan,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@@H]3CC[C@@H](C)[C@H](O)C[C@@](C)(/C=C/C=C\Br)OC(=O)C[C@](O)(C2)O3)[C@H](OC)[C@@H]1OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
76,CHEMBL3260943,,CCC[C@H]1C[C@@H](OC)C/C(C)=C\[C@@H]2C[C@@H](OC(=O)CCCCc3coc(CCCNC(=O)OC)n3)C[C@H](CC(=O)O1)O2,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
77,nan,,C/C=C1/C[C@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
78,nan,,CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@H]3[C@@H]4C=C5C(=O)[C@H](C)[C@@H](O)CCC[C@H](/C=C/[C@H](C)O)OC(=O)C[C@H]5[C@@H]4C=C[C@@H]3[C@@H]2O)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,6.0,"[3, 7, 8, 9, 10, 11]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:32.179547
79,nan,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]3[C@H]1OC(=O)c1cc(O)c(O)c(O)c1[C@H]1C(=O)[C@H](O)C[C@@]1(O)C(=O)O[C@@H]32)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
80,nan,,CC(=O)O[C@@]1(C)C(=O)OC/C2=C/CN(C)CC[C@@H](OC(=O)[C@@](O)([C@@H](C)Cl)C[C@H]1C)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
81,nan,,O=C1OC[C@@H]2O[C@H](OC(=O)c3cc(O)c(O)c(O)c3-c3c1cc(O)c(O)c3O)[C@H]1OC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]1[C@H]2O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
82,nan,,C[C@H]1CCC(=O)[C@@H]2CC(=O)c3c(cc(O)cc3O2)CC(=O)O1,non_standard_macrocycle,12.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
83,nan,,C=C1C(=O)O[C@H]2CC(=O)n3ccc(c32)COC(=O)[C@](C)(OC(C)=O)[C@@H](C)[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
84,nan,,CC(=O)C[C@]1(O)C(=O)C=C2C(=O)O[C@H]3[C@@H]4OC(=O)c5cc(O)c(O)c(O)c5-c5c(cc(O)c(O)c5O)C(=O)OC[C@H]3O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H]4OC(=O)c3cc(O)c(O)c4c3[C@H]2[C@@]1(O)O4,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
85,nan,,CCCCC[C@@H]1OC(=O)c2cc(ccc2C)Oc2ccc(O)c(C=O)c2/C=C\[C@@H]1O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
86,nan,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](C)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,6.0,"[3, 7, 8, 9, 10, 11]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:32.266083
87,CHEMBL1551810,,CC(C)(C)[C@@H]1COC(=O)[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
88,nan,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
89,nan,,CO[C@@H]1/C=C(/C)C[C@H](/C=C/C#C[C@H]2C[C@@H]2Cl)OC(=O)[C@@H](C)[C@]2(O)C[C@H](O[C@@H]3O[C@@H](C)[C@H](O[C@@H]4O[C@@H](C)[C@H](O)[C@@](C)(O)[C@H]4OC)[C@@](C)(O)[C@H]3OC)[C@@H](C)[C@@H](O2)[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
90,CHEMBL3215313,,C=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2C2C(O)(O3)C3(O)OC4(C(=O)OC5C(O)COC54O)C12CC3=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
91,nan,,C[C@@H]1C(=O)OCC(=O)N(C)[C@@H](Cc2ccccc2)[C@@H](O)CC(=O)O[C@@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
92,nan,,C=C[C@H]1[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OCC[C@@H]3C(=CO[C@@H](O[C@H]4O[C@@H](CO)[C@H](OC(=O)/C=C\c5ccc(O)cc5)[C@@H](O)[C@@H]4O)[C@@H]3C=C)C(=O)OCC[C@H]21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
93,nan,,COc1cc2cc(c1Cl)N1CC(=O)C(C)(O)C(=O)N(C)C(C)C(=O)O[C@@H](CC1=O)[C@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C/C=C(\C)C2OC,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
94,nan,,COC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OCC(NC(=O)[C@H]2C(O)CCN2C(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
95,nan,,C/C=C1/C[C@@H](C)[C@@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
96,nan,,C[C@@H]1C[C@@]2(C)CC(=O)O[C@@H]3CCN4CC[C@H](COC(=O)[C@]1(C)O2)[C@H]34,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
97,CHEMBL1727544,,O=C(C[C@@H]1C/C=C\C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC[C@@H](Cc2ccccc2)NC1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
98,nan,,CCC(=O)/C(C)=C/[C@H](O)C[C@@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:32.371987
99,nan,,CC[C@H]1O[C@H]1C[C@](C)(O)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@](C)(O)[C@@H](OC(C)=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:32.409528
100,nan,,C=C[C@@H]1[C@@H]2[C@@H]3/C=C\CC(=O)O[C@@]45C[C@@H](C)[C@@]6(O)[C@@H](C=C(CO)C[C@]7(O)C(=O)C(C)=C[C@H]76)[C@@H]4[C@@]5(C)COC(=O)[C@H]3[C@@H](/C=C/C=C/C=C/C=C/CCC)[C@@H]21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
101,CHEMBL1079558,,O=C(C[C@H]1C/C=C/CCC(=O)O[C@@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
102,nan,,CCC(=O)O[C@H]1/C=C\[C@H](C)[C@H](/C(C)=C/C=C/[C@H](C)C[C@H]2O[C@@H]2[C@H](C)[C@@H](O)CC)OC(=O)C[C@H](O)CC[C@]1(C)O,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:32.465657
103,nan,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)NC[C@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
104,nan,,C/C=C1/C[C@@H](C)[C@@H](O)C(=O)OC/C2=C/CN(C)CC[C@@H](OC1=O)C2=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
105,nan,,C[C@@H]1CCCCCCCc2cc(OC(=O)c3ccc(Br)cc3)cc(OC(=O)c3ccc(Br)cc3)c2C(=O)O1,standard_macrolactone,12.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:32.498502
106,nan,,C/C=C1/C[C@H](C)[C@](C)(O)C(=O)OCC2=CCN3CC[C@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
107,CHEMBL3623739,,O=C(C#Cc1ccccc1)N/C=C/C[C@H]1C[C@@H](O)CC/C=C/Cc2cccc(O)c2C(=O)O1,standard_macrolactone,12.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_12/standard/numbered/CHEMBL3623739_numbered.png,2026-03-19 02:40:32.525375
108,nan,,O=C1OCC(O)C(C2OC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)c4c3C(=O)OC2C4O)OC(=O)c2cc(O)c(O)c(O)c2-c2cc1c(O)c(O)c2O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
109,nan,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
110,CHEMBL1669768,,Cc1ccc(S(=O)(=O)Oc2cc3c(c(OS(=O)(=O)c4ccc(C)cc4)c2)C(=O)O[C@H](C)CCCCCCC3)cc1,standard_macrolactone,12.0,,,failed,non-ring atom 9 marked aromatic,,,ring_size_12/standard/numbered/CHEMBL1669768_numbered.png,2026-03-19 02:40:32.560378
111,nan,,O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)CO[C@H]([C@H]1O)[C@@H]2OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
112,nan,,C/C=C1/C[C@@H](C)[C@](C)(O)C(=O)OC[C@H]2CCN3CC[C@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
113,CHEMBL1710965,,O=C(N[C@@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@@H](c2ccccc2)OC1=O)OCC1c2ccccc2-c2ccccc21,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
114,nan,,CC/C=C\C=C/C(=O)N/C=C\C[C@H]1C[C@@H](O)[C@@H](C)C/C=C/Cc2ccc(F)c(O)c2C(=O)O1,standard_macrolactone,12.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:32.602819
115,nan,,CC(C)(C)[C@H]1COC(=O)[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C/C=C\C[C@@H](CC(=O)N[C@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
116,nan,,C[C@@H]1CCC[C@H](O)CC(=O)c2c(O)cc(O)cc2CC(=O)O1,standard_macrolactone,12.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:32.631438
117,nan,,C[C@H]1C[C@@](O)([C@H](C)O)C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@@]1(C)O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
118,nan,,CC[C@H](O)[C@@H](C)[C@@H]1O[C@@H]1C[C@@H](C)/C=C/C=C(\C)[C@@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:32.679522
119,nan,,O=C(C[C@@H]1C/C=C\C[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@@H](Cc2c[nH]c3ccccc23)NC1=O)NCCO,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
120,nan,,C/C=C1\C(=O)OC2CCN3CCC(COC(=O)C(C)(O)C(C)C1O)C23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
121,nan,,C=C(C#N)CO[C@@H]1O[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]([C@@H]1O)[C@@H]2O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
122,nan,,CC(=O)O[C@H]1/C=C\[C@H](C)[C@@H](/C(C)=C/C=C/[C@H](C)C[C@@H](C)/C=C(\C)[C@H](O)[C@H](C)O)OC(=O)C[C@@H](O)CC[C@@]1(C)O,standard_macrolactone,12.0,,,success,,6.0,"[3, 4, 7, 8, 8, 11]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:32.740763
123,nan,,COc1cc2c(c(OC)c1)C(=O)O[C@H](C)CCCCCCC2,standard_macrolactone,12.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:32.760483
124,nan,,CC(C)(C)OC(=O)C[C@@H]1C/C=C\C[C@H](CC(=O)NCCO)C(=O)N2CCC[C@@H]2COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
125,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H]([N+](C)(C)[O-])[C@@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)O,standard_macrolactone,12.0,,,success,,8.0,"[3, 4, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:32.815619
126,nan,,CC(C)(C)OC(=O)C[C@H]1C/C=C\C[C@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N[C@@H](c2ccccc2)COC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
127,nan,,CCC[C@@H]1OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)C(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
128,CHEMBL1606783,,CC(=O)C[C@H](O)CC(=O)[C@H]1OC(=O)CCCCCCCc2ccccc21,standard_macrolactone,12.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_12/standard/numbered/CHEMBL1606783_numbered.png,2026-03-19 02:40:32.846679
129,nan,,CC/C=C/[C@H]1CCC[C@H](O[C@H]2C[C@@H](OC)[C@H](OC)[C@@H](C)O2)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@H](O[C@@H]5O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)[C@@H](O)[C@H]4C=C[C@H]3[C@@H]2CC(=O)O1,standard_macrolactone,12.0,,,success,,6.0,"[3, 7, 8, 9, 10, 11]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:32.892376
130,nan,,CC[C@H]1OC(=O)[C@@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@H](C)C(=O)/C=C\[C@@H]1C,standard_macrolactone,12.0,,,success,,7.0,"[3, 4, 7, 8, 10, 11, 12]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:32.933748
131,nan,,O=C1C[C@]2(O)OC(=O)[C@H](OC1=O)[C@H]2c1c(C(=O)O[C@H]2[C@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@@H](O[C@@H]2OC(=O)c2cc(O)c(O)c(O)c2)[C@H]3O)cc(O)c(O)c1O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
132,nan,,O=C(O)C[C@@H]1C(=O)O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)OC[C@H]2O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]3OC(=O)c2cc(O)c(O)c3c2[C@@H]1[C@H](O)C(=O)O3,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
133,nan,,C/C=C1/C[C@@H](C)[C@@](O)(CO)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC1=O)[C@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
134,nan,,C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OC[C@H]2CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
135,nan,,C/C=C1/C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CC[N+]3(C)CC[C@@H](OC1=O)[C@@]23O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
136,nan,,COc1cc(O)cc2c1C(=O)O[C@H](C)[C@@H](O)CCCCCC2,standard_macrolactone,12.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:32.986647
137,nan,,C/C=C1/C[C@H](C)[C@@](C)(OC(C)=O)C(=O)OCc2ccn3c2[C@H](CC3=O)OC1=O,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
138,nan,,CCC(=O)C[C@H](O)C/C=C(C)/C=C(C)/C=C(C)/C=C/C(=O)O[C@H]1CCCC(=O)O[C@@H]([C@@H](C)C/C(C)=C/[C@@H](C)[C@H](O)C[C@@H](C)O)C/C=C(/C)C[C@@H]1C,standard_macrolactone,12.0,,,success,,4.0,"[3, 6, 8, 9]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.025130
139,nan,,C=C1C(=O)OCC2=CCN3CC[C@@H](OC(=O)[C@](C)(O)[C@]4(CO4)[C@H]1C)[C@@H]23,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
140,CHEMBL8097,,CCCCCCC[C@H]1OC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C)OC(=O)[C@H]1C,non_standard_macrocycle,12.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
141,nan,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3C=C[C@H]4[C@@H]5CC(=O)O[C@@H](C6CC6)CCC[C@H](O[C@H]6CC[C@H](N(C)C)[C@@H](C)O6)[C@@H](C)C(=O)C5=C[C@H]4[C@@H]3C2)[C@H](OC)[C@@H]1OC,standard_macrolactone,12.0,,,success,,6.0,"[3, 7, 8, 9, 10, 11]",ring_size_12/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.079019
142,nan,,O=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
143,nan,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
144,CHEMBL1710668,,O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@H]1CC(=O)N(CCO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
145,nan,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](OC(=O)CCCC(=O)NCCCCCCO)C[C@H]2[C@H](O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,4.0,"[3, 9, 10, 11]",ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.126908
146,nan,,CO[C@@H]1[C@H](O[C@H]2[C@H](OC)CO[C@@H](O[C@H]3C[C@H]4CC(=O)[C@@]5(O)O[C@H](C[C@H]5C)C(C)(C)[C@@H](/C=C/C=C/C=C/C(C)C)OC(=O)C[C@H](O4)[C@@H]3C)[C@@H]2OC)O[C@@H](C)[C@@H](O)[C@@H]1OC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
147,nan,,CCCCC(C)CC1NC(=O)C(C)NC(=O)C(Cc2ccccc2)NC(=O)CC(C(C)C)OC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
148,nan,,C[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C\C[C@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
149,nan,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)C(C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([N+](C)(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
150,nan,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)N[C@H](C)C(C)=O)[C@@H](C)OC1=O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
151,nan,,CO[C@@H]1/C=C/C(=O)O[C@@H](C)CCC/C=C\[C@@H]2C[C@H](O)C[C@H]21,standard_macrolactone,13.0,,,success,,4.0,"[3, 9, 10, 11]",ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.189318
152,nan,,C[C@H]1CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@H](O)[C@H]([Se]c2ccccc2)CC(=O)O1,standard_macrolactone,13.0,,,success,,5.0,"[3, 9, 10, 11, 12]",ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.229387
153,nan,,O=C1/C=C/[C@@H](O)[C@@H]2C[C@@H](O)C[C@H]2/C=C/CCCCO1,standard_macrolactone,13.0,,,success,,3.0,"[9, 10, 11]",ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.260312
154,nan,,O=C(C[C@H]1C/C=C\CC[C@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
155,nan,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
156,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
157,nan,,COc1ccc(C[C@H]2NC(=O)[C@]34OC(=O)O/C=C\[C@](C)(O)C(=O)[C@H](C)C/C=C\[C@@H]3[C@@H](O)C(C)=C(C)[C@H]24)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
158,nan,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
159,CHEMBL383015,RADANAMYCIN,COc1c(O)cc2c(O)c1CC(C)OC(=O)c1c(O)cc(O)c(Cl)c1CCC(=O)N2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
160,nan,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
161,nan,,C[C@H]1CCC/C=C\[C@@H]2CC(=O)C[C@H]2[C@H](O)/C=C\C(=O)O1,standard_macrolactone,13.0,,,success,,4.0,"[3, 9, 10, 11]",ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.353492
162,nan,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
163,nan,,C/C=C1\CC(c2cc(CO)cc(NCC(O)C3CCCCC3)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=O,standard_macrolactone,13.0,,,failed,non-ring atom 4 marked aromatic,,,ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.386167
164,nan,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
165,nan,,O=C1CCC/C=C\CCOC(=O)c2c(O)cc(O)c(Cl)c2C1,standard_macrolactone,13.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.413691
166,nan,,O=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H]2CCCN2C1=O)N[C@@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
167,CHEMBL1079179,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)/C=C\[C@H](C)[C@H](C)OC2=O,standard_macrolactone,13.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_13/standard/numbered/CHEMBL1079179_numbered.png,2026-03-19 02:40:33.440899
168,nan,,CC(C)CCCCCCCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H]1COC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)[C@@H](C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
169,nan,,COc1ccc(S[C@@H]2CC(=O)O[C@@H](C)CCC/C=C/[C@@H]3C[C@H](O)C[C@H]3[C@@H]2O)cc1,standard_macrolactone,13.0,,,success,,5.0,"[3, 9, 10, 11, 12]",ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.487728
170,nan,,C/C1=C/C(=O)O[C@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@H](C)C1)[C@H]23,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
171,nan,,CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H]([C@H](C)O)[C@@](C)(O)[C@H](O)[C@@H](C)C3=C(C)C[C@@]2(C)O3)[C@@H]1O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
172,nan,,C[C@@H]1C/C(CO)=C\CC(=O)O[C@H](C)C/C=C\C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
173,nan,,CC(=O)O[C@@H]1/C=C/C(=O)O[C@@H](C)CCC/C=C\[C@@H]2C[C@H](O)C[C@H]21,standard_macrolactone,13.0,,,success,,4.0,"[3, 9, 10, 11]",ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.541516
174,nan,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
175,nan,,C/C=C1\CC(c2cc(CO)cc(NCC(C)(O)CCOC)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,failed,non-ring atom 4 marked aromatic,,,ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.567109
176,nan,,CCCC[C@H](C)[C@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
177,nan,,CC(C)(C)[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N[C@@H](CO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
178,nan,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)/C=C\[C@H](C)[C@@H](C)OC2=O,standard_macrolactone,13.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.600388
179,nan,,C/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCC3CCC4CC(=O)CC3C42)OC1=O,standard_macrolactone,13.0,,,failed,non-ring atom 4 marked aromatic,,,ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.626020
180,nan,,CC(C)CCC[C@H]1CC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
181,nan,,C[C@H]1CCC/C=C\[C@@H]2C[C@@H](O)C[C@H]2[C@H](O)/C=C\C(=O)O1,standard_macrolactone,13.0,,,success,,4.0,"[3, 9, 10, 11]",ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.668586
182,nan,,CCNCC/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,failed,non-ring atom 4 marked aromatic,,,ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.690633
183,nan,,CCCCCC(CC(=O)N1N=CCCC1C(=O)N[C@H]1COC(=O)[C@H]2CCCNN2C(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)NC1=O)C(=O)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
184,CHEMBL26966,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
185,nan,,CCCCCC[C@H](C)[C@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
186,nan,,CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@@H](C)O2)C(C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([N+](C)(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
187,nan,,CC1CCCC=CC2CC(OC(=O)CN(C)C)CC2C(O)C=CC(=O)O1,standard_macrolactone,13.0,,,success,,4.0,"[3, 9, 10, 11]",ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.754982
188,nan,,Nc1ccc(CC[C@H]2CCC/C=C/[C@@H]3C[C@H](O)C[C@H]3[C@H](O)/C=C/C(=O)O2)cc1,standard_macrolactone,13.0,,,success,,4.0,"[3, 9, 10, 11]",ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.787696
189,nan,,CCCCCC[C@@H](C)[C@@H]1OC(=O)[C@H](CO)NC(=O)[C@H](C(=O)c2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H]1C,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
190,CHEMBL1087150,,O=C(C[C@H]1C/C=C/CCCC(=O)O[C@H](c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
191,nan,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC/N=C(\N(C)C)N2CCOCC2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
192,nan,,CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
193,nan,,O=C1CCC/C=C/C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)NC[C@H](c2ccccc2)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
194,nan,,COc1ccc(C[C@H]2NC(=O)[C@]34OC(=O)O/C=C\[C@@](C)(O)C(=O)[C@@H](C)C/C=C\[C@H]3[C@H]3O[C@@]3(C)[C@@H](C)[C@H]24)cc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
195,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@](C)(O)C[C@@H](C)C2=C(C)C(=O)[C@@]1(C)O2,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
196,nan,,C[C@H]1COC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H](CC(=O)N(CCO)Cc2ccccc2)C(=O)N1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
197,nan,,O=C(C[C@H]1C/C=C/CC[C@@H](Cc2ccc(F)cc2)C(=O)OC[C@H](c2ccccc2)NC1=O)NCCO,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
198,nan,,C/C=C1\CC(c2cc(CO)cc(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C2(O)CCCC3CC(=O)CCC32)OC1=O,standard_macrolactone,13.0,,,failed,non-ring atom 4 marked aromatic,,,ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.872086
199,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)C[C@H](C)[C@H](O2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
200,nan,,C/C1=C/C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@H](C)C1)[C@H]23,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
201,CHEMBL1987060,,CC1CCC/C=C/C2CC(O)CC2C(O)/C=C/C(=O)O1,standard_macrolactone,13.0,,,success,,4.0,"[3, 9, 10, 11]",ring_size_13/standard/numbered/CHEMBL1987060_numbered.png,2026-03-19 02:40:33.917870
202,nan,,CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC)[C@H](C)CC,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
203,nan,,C/C=C1\CC(c2cc(CO)c(CCCCC)c(NCC(C)O)c2)C#CC2CC(=O)Oc3cc(O)c(cc32)CC(C(C)(O)C2CCC(=O)CC2)OC1=O,standard_macrolactone,13.0,,,failed,non-ring atom 4 marked aromatic,,,ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.947731
204,nan,,CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
205,nan,,CC(=O)C[C@H](O)CC(=O)[C@@H]1OC(=O)CCCCCCCCc2ccccc21,standard_macrolactone,13.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:33.973884
206,nan,,COC(=O)c1ccccc1S[C@@H]1CC(=O)O[C@@H](C)CCC/C=C/[C@@H]2C[C@H](O)C[C@H]2[C@@H]1O,standard_macrolactone,13.0,,,success,,5.0,"[3, 9, 10, 11, 12]",ring_size_13/standard/numbered/nan_numbered.png,2026-03-19 02:40:34.011665
207,nan,,C=C1/C=C\[C@@H]([C@H](C)C(=C)C)OC(=O)C[C@]2(O)O[C@@H](CC(=C)[C@H]2C)[C@@H]2O[C@H]2C1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
208,nan,,O=C(C[C@H]1C/C=C\CC[C@@H](Cc2ccc(F)cc2)C(=O)O[C@@H](c2ccccc2)CNC1=O)N[C@H](CO)Cc1ccccc1,non_standard_macrocycle,13.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
209,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:34.086679
210,nan,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC#Cc2cc(-c3ncccn3)no2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,14.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:34.155661
211,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\Oc3ccc(-n4cccn4)nc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:34.220547
212,CHEMBL3092224,,CC(=O)OCC1=C(C)C[C@H]([C@@H](C)[C@H]2CC[C@H]3[C@@H]4C[C@H]5O[C@]56[C@@H]5C=CC(=O)[C@]6(COC(=O)CC/C=C/CCC(=O)O5)[C@H]4CC[C@@]32C)OC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
213,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)[C@@H](N)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:34.291937
214,nan,,CCC(=O)O[C@H]1[C@@H](OC(C)=O)[C@]2(COC(C)=O)[C@@H](OC(=O)c3ccccc3)[C@@H](O)[C@@H]3OC(=O)[C@@H](C)[C@@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@]2([C@H](OC(=O)c2ccccc2)[C@@H]14)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
215,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCSc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:34.363164
216,CHEMBL1256555,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL1256555_numbered.png,2026-03-19 02:40:34.423149
217,nan,,CCCCCNC(=O)CCCCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:34.486850
218,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C/C=C/Cn3cnc(-c4cccnc4)c3)C(=O)N[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:34.552989
219,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:34.617837
220,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H]2[C@@H]1OC(=O)N2CCCCn1cnc(-c2cccnc2)c1,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:34.682083
221,CHEMBL1078360,,COc1ccc(CO[C@@H]2/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c3cc(OC)cc(O)c3C(=O)O[C@H]2C)cc1,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL1078360_numbered.png,2026-03-19 02:40:34.702935
222,nan,,C=CCCC(=O)O[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:34.773410
223,CHEMBL1097413,,C[C@@H]1OC(=O)c2c(O)cc(NCc3ccccc3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL1097413_numbered.png,2026-03-19 02:40:34.793204
224,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:34.859993
225,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2ccccn2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:34.925811
226,nan,,CC[C@@H]1OC(=O)C[C@@H](O[C@H]2C[C@@](C)(O)[C@H](O)[C@@H](C)O2)[C@H](C)[C@H](O[C@@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:34.982921
227,CHEMBL1256546,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL1256546_numbered.png,2026-03-19 02:40:35.046811
228,nan,,C[C@H]1CCCC(=O)CCC/C=C\c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:35.065403
229,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cncc3ccccc23)[C@H](C)[C@@H]2OC(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:35.129994
230,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCc3ccnc4ccccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:35.208905
231,nan,,COc1cc(O)c2c(c1)/C=C/CCCC(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:35.227879
232,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCCc3ccccc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:35.293262
233,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@](C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
234,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3cccnc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
235,CHEMBL1097699,,C[C@@H]1OC(=O)c2c(O)cc(NCCO)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL1097699_numbered.png,2026-03-19 02:40:35.327313
236,nan,,CO[C@H]1[C@H](C)O[C@@H](O[C@@H]2C[C@H]3O[C@@](O)(C2)[C@H](C)C(=O)O[C@@H](/C=C/C=C/Br)C[C@@H](C)/C=C\C[C@H](O)[C@@H]3C)[C@H](OC)[C@@H]1OC,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
237,CHEMBL1214761,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL1214761_numbered.png,2026-03-19 02:40:35.398223
238,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccco1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
239,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCC(=O)NC3CCCCC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:35.472089
240,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:35.538594
241,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:35.593630
242,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC/C=C/c2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:35.657430
243,nan,,C/C(=C/C=C\C[C@H](O)C[C@@H]1CCC[C@H]2O[C@@](O)(CC[C@@H]3CC[C@H](O3)C(=O)O1)[C@H](O)[C@@H](O)[C@@H]2C)C/C=C\C=C/CCO,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
244,CHEMBL418067,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C3CCCCC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL418067_numbered.png,2026-03-19 02:40:35.730020
245,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
246,nan,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(-c4csnn4)nc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,14.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:35.804268
247,CHEMBL1097784,,C[C@@H]1OC(=O)c2c(O)cc(OCCn3ccnn3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL1097784_numbered.png,2026-03-19 02:40:35.823332
248,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
249,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OCCNCCCCNCc2ccc(Oc3ccccc3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:35.894319
250,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:35.959621
251,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)NNCc2cccc([N+](=O)[O-])c2)[C@](C)(O)C[C@@H](C)/C(=N\OCCCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:36.028068
252,nan,,COc1ccc(C2CC(=O)Oc3cc4c(c(OC)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1OC(C)C,standard_macrolactone,14.0,,,failed,non-ring atom 12 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:36.047820
253,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)C[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)C[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 5, 7, 8, 10, 10, 11, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:36.106469
254,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCCC2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:36.172522
255,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccc([N+](=O)[O-])c2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:36.237282
256,nan,,C=C1/C=C(\C)[C@H](CC)OC(=O)[C@@H](C)C(=O)[C@](C)(CO)C/C(OC)=C/[C@@H](C)C1,standard_macrolactone,14.0,,,success,,9.0,"[3, 4, 6, 8, 10, 12, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:36.288148
257,CHEMBL12589,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCNC2=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL12589_numbered.png,2026-03-19 02:40:36.359845
258,CHEMBL532,ERYTHROMYCIN,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL532_numbered.png,2026-03-19 02:40:36.425161
259,CHEMBL313882,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)NC2CCCCC2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL313882_numbered.png,2026-03-19 02:40:36.445554
260,CHEMBL3392931,,CC[C@@H]1OC(=O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@](C)(O)C[C@H](C)C(=O)[C@@H](C)[C@H](O)[C@@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL3392931_numbered.png,2026-03-19 02:40:36.510991
261,nan,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)N/C=C/c2ccc(-c3ccccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:36.577538
262,nan,,CCCCCCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)CCCCCCC)[C@@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:36.643489
263,nan,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)C(N)C(C)C(OC(=O)O)C1(C)OC(=O)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:36.709010
264,nan,,COc1cc(O)c2c(c1)/C=C/C[C@@H]1OC(C)(C)O[C@@H]1C(=O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:36.729567
265,nan,,COc1cc(O)c2c(c1)CCCC(O)C(O)C(=O)C=CCC(C)OC2=O,standard_macrolactone,14.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:36.749161
266,CHEMBL1669776,,CC(=O)Oc1cc2c(c(OC(C)=O)c1)C(=O)OCCCCCCCCCC2,standard_macrolactone,14.0,,,failed,non-ring atom 4 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL1669776_numbered.png,2026-03-19 02:40:36.768202
267,nan,,C=C[C@]12OC(=O)N(CCCCn3cc(Cl)c4ncccc43)[C@@H]1[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:36.838462
268,nan,,CCCCNC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:36.907387
269,nan,,COC1C=CCCC=CC(=O)OC(C(C)C(=O)CCCC2CC(=O)NC(=O)C2)C(C)=CC(C)C1O,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 6, 7, 8]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:36.942840
270,nan,,CC(=O)OCC12C(OC(C)=O)C(=O)C3C(O)C14OC3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)OC(C(OC(C)=O)C2OC(C)=O)C4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
271,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nc(-c4ccccc4)cs3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:37.015232
272,nan,,C[C@H]1COC(=O)CC=C[C@@H](C)[C@@H]2C=C[C@H](O)[C@@H](COC1=O)O2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
273,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)C(C)C)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/C=C/c2cccnc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:37.087017
274,CHEMBL3650149,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)CN2CCOCC2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(=O)CN(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)C2N(CCCOc3cc(C(=O)Nc4c(Cl)cncc4Cl)ccc3OC)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL3650149_numbered.png,2026-03-19 02:40:37.157227
275,CHEMBL1651523,,COc1cc(O)c2c(c1)CCCCCC(=O)/C=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL1651523_numbered.png,2026-03-19 02:40:37.176038
276,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:37.243281
277,nan,,CC[C@H](C)[C@@]1(O)CC(=O)O[C@H](C)[C@@](O)(C(C)C)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
278,nan,,COc1cc(O)c2c(c1Br)C(=O)OCC(=O)NCC(=S)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
279,nan,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)/C(C)=C/[C@]1(C)O,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:37.312175
280,nan,,COc1cc(O)c2c(c1Br)C(=O)OCCNCC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
281,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(=O)[C@@H](C)[C@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@]1([C@H](OC(C)=O)[C@@H]4C(=O)[C@@H]2OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
282,nan,,COc1cc(O)c(Cl)c2c1C(=O)OC(C)CCC(=O)CCC(OC)CC(=O)C2,standard_macrolactone,14.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:37.344747
283,nan,,CC(C)[C@@]1(O)C(=O)OCC2=CCN3CC[C@@H](OC(=O)[C@@](O)(C(C)C)[C@@H](O)C(=O)O[C@@H]1C)[C@@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
284,nan,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(N)=O)C[C@@H](C)/C(=N\O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,14.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:37.418505
285,CHEMBL2375656,,COc1cc(O)c2c(c1)CC(=O)CCCC(=O)CCC[C@@H](C)OC2=O,standard_macrolactone,14.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL2375656_numbered.png,2026-03-19 02:40:37.438378
286,nan,,C[C@H]1C[C@H]2O[C@@H]2CC/C=C\C(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:37.458452
287,CHEMBL1256537,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL1256537_numbered.png,2026-03-19 02:40:37.523218
288,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:37.586570
289,CHEMBL1214762,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL1214762_numbered.png,2026-03-19 02:40:37.649117
290,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(O)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:37.712314
291,CHEMBL1668417,,COc1cc(O)c2c(c1)/C=C\CCCC(=O)C[C@H](Br)C[C@H](C)OC2=O,standard_macrolactone,14.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL1668417_numbered.png,2026-03-19 02:40:37.732631
292,nan,,CCCCCCCCCCCCC(=O)O[C@H]1[C@H](C)OC(O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc3ccccc3)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:37.803599
293,nan,,COc1ccc(OC)c(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)c1,standard_macrolactone,14.0,,,failed,non-ring atom 15 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:37.824539
294,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:37.891702
295,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc3cccnc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2CC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:37.956244
296,nan,,CO[C@@]12CC[C@@H]3CC[C@H](O3)C(=O)O[C@H](C[C@@H](O)C/C=C\C=C(\C)C/C=C\C=C/CCO)CCC[C@@H](O1)[C@@H](C)[C@H](O)[C@H]2O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
297,nan,,C=CCN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](OC(=O)Cc3cccnc3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCCCn4ccc5cccnc54)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:38.030082
298,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc4ncccc43)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:38.096932
299,nan,,CCCNC(=O)CCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:38.160606
300,nan,,CC[C@H](C)[C@]1(O)C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](O)(C(C)C)[C@@H](C)OC(=O)[C@@H]1O)[C@H]23,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
301,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2ccc(-c3ccccn3)s2)C[C@@H](C)/C(=N\OC)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:38.239298
302,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](O)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cc(-c4ccccn4)nn3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:38.309954
303,nan,,C/C=C/C(=O)OC1C(OC(=O)c2ccc(=O)n(C)c2)C2OC(=O)C(C)C(C)c3ncccc3C(=O)OCC3(C)OC4(C(OC(C)=O)C3C(OC(C)=O)C(OC(C)=O)C14COC(C)=O)C2(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
304,nan,,O=C1CCCCCCCCCCCCO1,standard_macrolactone,14.0,,,success,,0.0,[],ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:38.335906
305,CHEMBL1078777,,CC[C@H]1C/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(OC)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL1078777_numbered.png,2026-03-19 02:40:38.355464
306,nan,,C=C1NC(=O)[C@@H](C)[C@@H](CC[C@@H](C)C(=O)/C=C/C(C)=C/C[C@@H](C)CCCCCCC)OC(=O)[C@H](C[C@@H](OS(=O)(=O)O)C(N)=O)NC(=O)[C@@H](C)CNC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
307,nan,,C=CCO[C@@H]1C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)COc2ccccc2)[C@H](C)[C@H]1OC1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:38.424355
308,nan,,COc1c2c(cc3c1C(c1cc4cc(C)ccc4n(CC(C)C)c1=O)CC(=O)O3)C=CCCCC(=O)CCCC(C)OC2=O,standard_macrolactone,14.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:38.444333
309,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cccc3cccnc23)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:38.511028
310,nan,,C[C@@H]1OC(=O)c2c(O)cc(NOCC(=O)O)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:38.530159
311,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:38.594803
312,nan,,O=C1O[C@H]2[C@@H]3OC(=O)c4cc(O)c(O)c(O)c4-c4c(cc(O)c(O)c4O)C(=O)O[C@H]3[C@H](O)O[C@@H]2COC(=O)c2cc(O)c(O)c3oc(=O)c4cc(O)c(O)c(c4c23)Oc2c1cc(O)c(O)c2O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
313,CHEMBL2159138,,CC/N=C1\O[C@H]2[C@H](O[C@@H]3[C@@H](C)[C@H](O[C@H]4C[C@@](C)(OC)[C@@H](O)[C@H](C)O4)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]3(C)OC)O[C@H](C)C[C@@H]2N1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL2159138_numbered.png,2026-03-19 02:40:38.677283
314,CHEMBL1099011,,CCCOc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,failed,non-ring atom 4 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL1099011_numbered.png,2026-03-19 02:40:38.697262
315,nan,,COc1cc(O)c2c(c1Br)C(=O)OCCN(C(=O)[C@H](C)N)CC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
316,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(-c5ccccc5)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:38.771340
317,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](NCC#Cc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:38.834263
318,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2cnc3ccccc3c2)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:38.898243
319,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)/C=C\[C@]1(C)O,standard_macrolactone,14.0,,,success,,10.0,"[3, 4, 4, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:38.949088
320,nan,,COc1ccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)c(OC)c1OC,standard_macrolactone,14.0,,,failed,non-ring atom 12 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:38.969336
321,CHEMBL1256547,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL1256547_numbered.png,2026-03-19 02:40:39.044828
322,nan,,C=CCO[C@@H]1C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccc(Cl)cc2)[C@H](C)[C@H]1OC1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:39.113830
323,nan,,COc1cc(O)c(Cl)c2c1C(=O)O[C@@H](C)CCC(=O)CC/C=C\C(=O)C2,standard_macrolactone,14.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:39.133220
324,nan,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(C(N)=O)s3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,14.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:39.202537
325,nan,,COc1cc(O)c2c(c1)/C=C\C[C@H](O)[C@@H](O)C(=O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:39.222801
326,CHEMBL276217,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@H]2CC(C)C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL276217_numbered.png,2026-03-19 02:40:39.293670
327,CHEMBL584552,,CCNC(=O)CO[C@H]1[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL584552_numbered.png,2026-03-19 02:40:39.359538
328,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCc2cccs2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:39.424699
329,nan,,CO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@]3(CO3)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:39.485735
330,nan,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3cccc(C(N)=O)c3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,14.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:39.553385
331,CHEMBL416337,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCN(C)C2=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL416337_numbered.png,2026-03-19 02:40:39.619554
332,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCC2CCCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:39.683636
333,nan,,CCOCCCNC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:39.748027
334,nan,,CCCC(=O)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:39.811652
335,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
336,nan,,C=C1NC(=O)C(C)C(CCC(C)C(=O)C=CC(C)=CCC(C)CCCCCCC)OC(=O)[C@H](CC(OS(=O)(=O)O)C(N)=O)NC(=O)[C@@H](C)CNC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
337,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=N\OCc3cc(-c4cccc(C#N)n4)no3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:39.891983
338,nan,,C[C@H]1CCCC(=O)CCCCCc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:39.910667
339,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
340,nan,,CCOC(=O)c1cn(CC)c2ccc(CCCN3CCN(CCC(=O)O[C@H]4[C@H](C)O[C@@H](O[C@H]5[C@H](C)[C@@H](O[C@@H]6O[C@H](C)C[C@H](N(C)C)[C@H]6O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]5C)C[C@@]4(C)OC)CC3)cc2c1=O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:39.985337
341,nan,,CC(=O)O[C@@H]1[C@H](OC(=O)C(C)C)[C@@H]2[C@@H](OC(C)=O)[C@@]34O[C@@]2(C)COC(=O)c2cccnc2C[C@@H](C)C(=O)O[C@@H]([C@H](OC(=O)c2ccc(=O)n(C)c2)[C@H](OC(C)=O)[C@@]13COC(=O)C(C)C)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
342,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](NC)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:40.057885
343,CHEMBL1315430,,CCC1OC(=O)C(C)[C@@H](O[C@H]2C[C@@](C)(OC)C(O)C(C)O2)C(C)[C@@H](O[C@@H]2OC(C)CC(N(C)C)C2O)[C@@](C)(O)CC(C)C(=O)[C@@H](C)C(O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL1315430_numbered.png,2026-03-19 02:40:40.120731
344,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccc(NC(=O)Cc3ccccn3)nc2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:40.186449
345,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(-c5ccc(C)cc5)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:40.252482
346,CHEMBL4068569,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C(F)=C\C[C@H](C)OC2=O,standard_macrolactone,14.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL4068569_numbered.png,2026-03-19 02:40:40.272167
347,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O/C=C\Cc2cncnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2Cl)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:40.337843
348,CHEMBL59405,,O=C(NC(Cc1ccccc1)C(O)CN1C/C=C\CCCCCCCC(c2ccccc2)OC1=O)O[C@H]1CO[C@H]2OCC[C@@H]12,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
349,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=C/c2cccc3cccnc23)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:40.409464
350,nan,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N/C(C)=O)[C@H](C)[C@@H](OC/C(=N/OCc3ccc(-c4cccc(N)n4)s3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,14.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:40.477318
351,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCc2ccc(Br)cc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:40.540590
352,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC/C=C/c2cccc3ncccc23)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:40.605576
353,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2ccnc(NC(=O)Cc3ccccn3)c2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:40.672639
354,CHEMBL3967300,,C[C@@H]1OC(=O)c2c(O)cc(N3CCNC3=O)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL3967300_numbered.png,2026-03-19 02:40:40.691969
355,nan,,CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)/C=C/c2ccc(O)c(O)c2)[C@@H](C)OC(=O)[C@@H](C)CNC(=O)[C@@H](C)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
356,nan,,CCCCCCCCCCCCCCCCO/N=C1/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:40.763278
357,nan,,COc1ccc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc1OC,standard_macrolactone,14.0,,,failed,non-ring atom 12 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:40.782894
358,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc4ncccc43)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:40.849363
359,nan,,C=CCO[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)O[C@H]3[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)OC)[C@H](O)[C@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:40.912144
360,nan,,C[C@@H]1/C=C\[C@@H](C)[C@H](/C=C/C#C/C=C/C(C)(C)[C@H](O)c2cccc(O)c2Br)OC(=O)/C=C\C[C@H](C)C[C@H](OC(N)=O)C1,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 7, 9, 11]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:40.947112
361,nan,,CC1CCCC(=O)CCCC=Cc2cc3c(c(O)c2C(=O)O1)C(c1cccc2ccccc12)CC(=O)O3,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:40.966430
362,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCN(C)Cc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:41.031399
363,nan,,CCCCCCC(=O)O[C@H]1[C@H](C)OC(O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc3ccccc3)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:41.100937
364,nan,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:41.167066
365,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:41.236465
366,nan,,C[C@@H]1C/C=C\C(=O)O[C@H](C)C[C@@H](O)C/C=C\C(=O)O1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
367,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nncs3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:41.311335
368,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCCNCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:41.381027
369,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCc3ccnc4c(OC)cccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:41.446660
370,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C[C@@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccc(=O)n(C)c1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
371,nan,,CCCCC[C@H]1CCCCC[C@@H](O)C[C@H](O)[C@H](O)/C=C/C(=O)O1,standard_macrolactone,14.0,,,success,,4.0,"[3, 9, 11, 12]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:41.486791
372,nan,,C[C@@H]1C[C@@H](O)/C=C\CCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:41.506440
373,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2C(NC(=O)CCCCc3cnc4c(OC)cccc4c3)C(=O)O[C@@]21C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:41.572884
374,nan,,CC[C@H]1OC(=O)[C@H](C)C(O[C@H]2C[C@](C)(OC)[C@@H](O)[C@@H](C)O2)[C@H](C)C(O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCOc2ccc(OC)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:41.637433
375,nan,,CC/C=N/C(=O)CCCCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:41.702176
376,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
377,nan,,COc1cc(OCC(=O)NC(C)C)cc2c1C(=O)OC(C)CCCC(=O)CCCCC2,standard_macrolactone,14.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:41.731233
378,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@@H](C)[C@H](N(C)C(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:41.801516
379,nan,,COc1cc2c(c(OC)c1)C(=O)O[C@@H](C)CCC[C@@H](O)CCCCC2,standard_macrolactone,14.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:41.821495
380,nan,,CCC(=O)O[C@H]1[C@@H](OC(C)=O)[C@]2(COC(C)=O)[C@@H](OC(=O)c3ccccc3)[C@@H](O)[C@@H]3OC(=O)[C@@H](C)[C@@H](C)c4ncccc4C(=O)OC[C@]4(C)O[C@@]2([C@H](OC(=O)c2ccccc2)[C@@H]14)[C@@]3(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
381,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccncc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:41.895772
382,nan,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NC/C=C/c3ccc(NC(C)=O)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:41.956968
383,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)O[C@@H]([C@H](OC(=O)c1cccnc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
384,nan,,COC(=O)c1ccc(COc2cc(O)c3c(c2)C=CCCCC(=O)CCCC(C)OC3=O)o1,standard_macrolactone,14.0,,,failed,non-ring atom 10 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:41.983734
385,nan,,COC(=O)c1cc(C(=O)OC)cc(-c2ccc(C3CC(=O)Oc4cc5c(c(OC)c43)C(=O)OC(C)CCCC(=O)CCCC=C5)o2)c1,standard_macrolactone,14.0,,,failed,non-ring atom 23 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:42.003932
386,CHEMBL83070,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)N2CCCCCC2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL83070_numbered.png,2026-03-19 02:40:42.024741
387,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCCNCCN2CCCC2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:42.087466
388,nan,,CCOC(=O)c1cn(C2CC2)c2ccc(CCCN3CCN(CCC(=O)O[C@H]4[C@H](C)O[C@@H](O[C@H]5[C@H](C)[C@@H](O[C@@H]6O[C@H](C)C[C@H](N(C)C)[C@H]6O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]5C)C[C@@]4(C)OC)CC3)cc2c1=O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:42.154199
389,nan,,CO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](OC(C)=O)[C@@H](C)C(=O)[C@@]3(CO3)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3OC(C)=O)[C@H]2C)O[C@@H](C)[C@@H]1OC(C)=O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:42.215673
390,nan,,C=C(CCC[C@@H](O)C[C@H](C)O)C[C@@H]1CC(=C)C[C@H](O)C/C(C)=C\[C@@H](O)CCCC(=O)O1,standard_macrolactone,14.0,,,success,,5.0,"[3, 5, 7, 9, 11]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:42.249971
391,nan,,CO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@]3(CO3)C[C@H](C)[C@H](O[C@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:42.310860
392,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OCCNCCCOCCOCCOCCCNc2ccc(Oc3ccccc3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:42.373210
393,nan,,C=C[C@@H]1[C@H]2[C@H](/C=C/C=C/C=C/CCC)[C@H]2[C@@H]2C(=O)OC[C@]3(C)[C@H]4[C@@H]5C=C(CO)C[C@]6(O)C(=O)C(C)=C[C@H]6[C@@]5(O)[C@H](C)C[C@]43OC(=O)C/C=C\C=C[C@H]12,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
394,nan,,CCC1OC(=O)C(C)C(=O)/C(C)=C/C(C)CC(C)C(=O)/C=C/C1C,standard_macrolactone,14.0,,,success,,8.0,"[3, 4, 7, 8, 10, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:42.423894
395,CHEMBL528543,,C/C1=C/[C@@H](C)[C@H](O)[C@@H](O)/C=C/CC/C=C/C(=O)O[C@@H]1[C@H](C)C(=O)/C=C/CC1CC(=O)NC(=O)C1,standard_macrolactone,14.0,,,success,,5.0,"[3, 4, 6, 7, 8]",ring_size_14/standard/numbered/CHEMBL528543_numbered.png,2026-03-19 02:40:42.459025
396,CHEMBL1095163,,CCCCOc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,failed,non-ring atom 5 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL1095163_numbered.png,2026-03-19 02:40:42.477865
397,CHEMBL1094226,,C[C@@H]1OC(=O)c2c(O)cc(OCC(O)CO)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL1094226_numbered.png,2026-03-19 02:40:42.496102
398,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCCC(=O)NCCc3ccc(O)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:42.561316
399,CHEMBL1256549,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCF)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL1256549_numbered.png,2026-03-19 02:40:42.624562
400,nan,,CCCN1C(C)O[C@@H]2[C@@H](C)[C@@H]1[C@H](C)C[C@@](C)(O)[C@H](OC1OC(C)CC(N(C)C)C1O)[C@@H](C)[C@H](OC1CC(C)(OC)C(O)C(C)O1)[C@@H](C)C(=O)O[C@H](CC)[C@@]2(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:42.688426
401,CHEMBL4061009,,COc1cc(O)c2c(c1)CCC[C@H](O)[C@H](O)[C@@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL4061009_numbered.png,2026-03-19 02:40:42.707924
402,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\OCc3ccc(C(N)=O)s3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:42.774289
403,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3ccccc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
404,nan,,COC1CC(O[C@@H]2C(C)C(=O)O[C@H](C)[C@H](C)C(OC(C)=O)C(C)C(=O)[C@]3(CO3)C[C@H](C)[C@H](OC3OC(C)CC(N(C)C)[C@H]3O)[C@H]2C)OC(C)[C@@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:42.847466
405,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)[C@@H](N(C)C)[C@H](C)[C@@H](O)[C@@]12CO2,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:42.918681
406,CHEMBL1099198,,COc1cc(O)c2c(c1)OCC[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
407,nan,,CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C/C=C/Cn3cnc4cccnc43)C(=O)N[C@]12C,standard_macrolactone,14.0,,,success,,14.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:42.996124
408,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccncc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CC3)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:43.062954
409,CHEMBL3948014,,CCNc1cc(O)c2c(c1)/C=C/C[C@@H]1OC(=O)O[C@@H]1C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O,standard_macrolactone,14.0,,,failed,non-ring atom 3 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL3948014_numbered.png,2026-03-19 02:40:43.083455
410,nan,,C[C@@H]1C[C@@H](O)CCCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:43.103364
411,nan,,CCCCCN[C@@H]1[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:43.168010
412,CHEMBL1404947,,CO[C@@H]1C[C@H](O[C@H]2[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)C[C@@H](N(C)C)[C@@H]3OC(C)=O)[C@H](C)C[C@]3(CO3)C(=O)[C@H](C)[C@H](OC(C)=O)[C@H](C)[C@H](C)OC(=O)[C@@H]2C)O[C@H](C)[C@@H]1OC(C)=O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL1404947_numbered.png,2026-03-19 02:40:43.231096
413,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ncccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:43.322190
414,CHEMBL1269447,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCc2csc(C)n2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL1269447_numbered.png,2026-03-19 02:40:43.397467
415,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@H]4C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
416,nan,,CC1C/C=C/C(O)C(O)CC/C=C/c2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:43.429644
417,CHEMBL3734946,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccccc3-c3cn(CCCCCC(=O)NO)nn3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL3734946_numbered.png,2026-03-19 02:40:43.505189
418,nan,,C=CCCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@](C)(O)[C@H](OC(=O)CCC=C)[C@@H](C)C(=O)[C@H](C)C[C@]2(C)O)O[C@H](C)C[C@@H]1N(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:43.569857
419,nan,,CO[C@@H]1/C=C\CC/C(C)=C\C/C(C)=C\C(=O)O[C@@H](CO)C1,standard_macrolactone,14.0,,,success,,4.0,"[3, 5, 10, 13]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:43.603493
420,CHEMBL3986872,,C[C@@H]1OC(=O)c2c(O)cc(NCCn3ccnc3)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL3986872_numbered.png,2026-03-19 02:40:43.629993
421,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCCCCc3ccnc4ccccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:43.708347
422,nan,,CC[C@H](C)[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](OC(C)=O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@H](OC)[C@H]2O)[C@@H](C)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(C)=O)[C@H]1C,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:43.775057
423,nan,,C=C1NC(=O)C(C)C(CCC(C)C(=O)/C=C/C(C)=C/CCC(C)CCCCCC)OC(=O)C(CCC(N)=O)NC(=O)C(C)CNC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
424,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)/C=C/c2ccc(F)cc2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:43.850266
425,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:43.914232
426,nan,,COc1cc(O)c2c(c1Br)C(=O)OCC(=O)N(C)CC(=O)N[C@H](c1nc(C)no1)CSC2,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
427,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(C)=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:43.988368
428,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](OC(=O)NCCc3ccccc3)[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\OC(=O)NCCc2ccccc2)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:44.059629
429,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)[C@@H](OC/C(=N\Oc3ccc(-c4nccs4)nc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:44.126074
430,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)/C(=N\O)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:44.192837
431,CHEMBL3577622,,C#CCO[C@@H]1[C@@H](C)[C@H](OC(=O)NCCCCCCCNC(=N)NC(=O)NC)[C@@H](C)C(=O)O[C@H](CC)C(C)(C)[C@@H]2OC(C)(C)O[C@H]([C@@H]2C)[C@H](C)C[C@@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL3577622_numbered.png,2026-03-19 02:40:44.256920
432,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)C(C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:44.321927
433,CHEMBL125014,,CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)N[C@H]1COC(=O)CCCC(CNC(=O)OCC(Cl)(Cl)Cl)OC(=O)[C@H](O)[C@H](CC2CCCCC2)NC1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
434,CHEMBL1079557,,O=C(C[C@@H]1C/C=C/CCCCC(=O)OCCNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
435,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCCC(=O)NCc3ccc(OC)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:44.406086
436,nan,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:44.471644
437,nan,,CO[C@@H]1C[C@H]2C=C[C@H]3C[C@H]4O[C@]2(/C(C)=C\[C@@H]2COC(=O)CCC5=C(/C=C\OC[C@H](O)[C@H]2OC1=O)C(=O)OC5=O)[C@@H]3[C@@H](O)[C@H]4C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
438,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CCC[C@@H]2c2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:44.550263
439,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)/C(=N\C(C)=O)[C@H](C)C(OC/C(=N\OCc3cc(-c4ccc(Br)s4)no3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:44.617177
440,nan,,COC(=O)c1ccc(-c2ccc(C3CC(=O)Oc4cc5c(c(O)c43)C(=O)OC(C)CCCC(=O)CCCC=C5)o2)cc1,standard_macrolactone,14.0,,,failed,non-ring atom 18 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:44.637172
441,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc4cccnc43)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:44.715590
442,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:44.784822
443,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Nc2nccs2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@@H](C)[C@@H](OC)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:44.860618
444,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CCCCO2)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)C2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:44.930151
445,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OC/C=C/c2cccs2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:44.995818
446,CHEMBL572017,,C/C=C1/[C@H]2OC=C(C(=O)O)[C@H]1CC(=O)OC[C@H](c1ccc(O)c(O)c1)OC[C@H]1O[C@@H](O2)[C@H](O)[C@@H](O)[C@@H]1O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
447,nan,,CO[C@]1(C)C[C@H](O[C@@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](C3CC3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:45.070019
448,nan,,CC[C@@H]1OC(=O)[C@@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@](C)(O[C@@H]2C[C@H](N(C)C)[C@H](O)[C@@H](C)O2)C[C@@H](C)C(=O)[C@H](O)[C@@H](O)C1(C)C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:45.137819
449,nan,,C[C@H]1C/C=C/[C@@H](O)[C@@H](O)CCC(O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:45.157803
450,nan,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccnc4ccccc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:45.224348
451,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCCCOc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:45.301404
452,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCCCCOCC#Cc3ccc4c(c3)c(=O)c(C(=O)O)cn4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:45.371483
453,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C/C=C/Cc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:45.441041
454,nan,,C[C@H]1C/C=C/CC/C=C/C(=O)Cc2cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:45.461900
455,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NN(CC)CCc2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:45.531898
456,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCCO)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:45.600536
457,nan,,CC1CCCC(=O)CCCC=Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:45.619637
458,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@](C)(F)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,14.0,"[3, 4, 4, 5, 6, 7, 8, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:45.688221
459,nan,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
460,nan,,COc1cc(O)c(Cl)c2c1C(=O)O[C@@H](C)CCC(=O)CCCCC(=O)C2,standard_macrolactone,14.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:45.715285
461,nan,,CCCCCCCN[C@@H]1[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(N(C)C)C2O)[C@](C)(O)C[C@H]1C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:45.780717
462,CHEMBL216252,,CCC(C)N(CC1CC1)[C@H]1C[C@@H](C)OC(O[C@@H]2[C@@H](C)[C@H](OC3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@]3(C)OC(=O)N(CCc4ccc(Cl)cc4)[C@@H]3[C@@H](C)C(=O)[C@H](C)C[C@]2(C)OC)[C@@H]1O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL216252_numbered.png,2026-03-19 02:40:45.849975
463,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCCN(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:45.911243
464,nan,,O=C1OCC/C=C/CC/C=C/C(=N/OCC(=O)N2CCCCC2)Cc2cc(OP(=O)(O)O)cc(O)c21,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:45.930148
465,CHEMBL3735212,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3cccc(-c4cn(CCCCCC(=O)NO)nn4)c3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C2=NCCN3C(=O)O[C@@]1(C)[C@H]3[C@H]2C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL3735212_numbered.png,2026-03-19 02:40:45.993842
466,CHEMBL3970233,,CN1Cc2cc(ccc2S(=O)(=O)C2CC2)NC(=O)OCc2cccc(c2)[C@@H](Nc2ccc3c(N)nccc3c2)C1=O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
467,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCCNCCc2ccccc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:46.063701
468,nan,,COc1cc(C2CC(=O)Oc3cc4c(c(O)c32)C(=O)OC(C)CCCC(=O)CCCC=C4)cc(OC)c1OC,standard_macrolactone,14.0,,,failed,non-ring atom 11 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:46.083366
469,nan,,CC1C(=O)OCCCn2ccc(c2)COC(=O)C(C)(O)C1(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
470,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCSc3nc(-c4cccnc4)c[nH]3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:46.167041
471,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:46.229433
472,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4ccccc4)C3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:46.306529
473,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](OC(=O)NCCNC(=O)c2ccc(C(C)(C)C)cc2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:46.368446
474,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(NCCCc3ccnc4ccc(OC)cc34)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:46.432743
475,nan,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)/C(C)=C/[C@]1(C)OC(=O)NCCCOc1ccc2ccccc2c1,standard_macrolactone,14.0,,,success,,11.0,"[3, 4, 4, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:46.488014
476,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccn2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCC#Cc2cncc3ccccc23)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:46.553099
477,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3ccnc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:46.616192
478,CHEMBL267568,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2CC(C)OC2=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL267568_numbered.png,2026-03-19 02:40:46.683083
479,CHEMBL1095165,,C[C@@H]1OC(=O)c2c(O)cc(C(O)(F)F)cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@H]1C,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL1095165_numbered.png,2026-03-19 02:40:46.702677
480,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)Cc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2ccc(-c3ncccn3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:46.770445
481,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)NC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2CC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:46.834635
482,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OCC#Cc2ccc(-c3nnn(C)n3)s2)C[C@@H](C)/C(=N\OC)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:46.898134
483,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(=O)c3ccccc3)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
484,nan,,CC[C@H](/C=C(\C)[C@@H]1C[C@@H](OC)C[C@H](O)C(C)(C)[C@@]2(O)O[C@@H](C[C@@H](OC)[C@H](O)C(=O)O1)C[C@@H](OC)[C@H]2O)CO,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
485,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC/C=C/c2cnc3ccccc3c2)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:46.978250
486,nan,,CC(C)(C)[C@H]1COC(=O)CCCC/C=C\C[C@H](CC(=O)NCCO)C(=O)N1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
487,CHEMBL574429,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL574429_numbered.png,2026-03-19 02:40:47.050152
488,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@H]4C,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
489,CHEMBL1080987,,O=C(C[C@H]1C/C=C/CCCCC(=O)OCCNC1=O)NCc1ccc(Cl)cc1,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
490,nan,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)N/C=C/c2ccc(-c3cccnc3)cc2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:47.129954
491,nan,,CC[C@H]1OC(=O)/C(C)=C/[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(Cc3ccccc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:47.193218
492,nan,,COc1cc(O)cc2c1C(=O)O[C@@H](C)CCCC(=O)CCCCC2,standard_macrolactone,14.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:47.212983
493,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
494,nan,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C3CC3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:47.302139
495,nan,,CC[C@H]1OC(=O)C(C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC(=O)N/C=C/c2ccc3cccnc3c2)C[C@@H](C)C(=O)[C@H](C)[C@H]2NC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:47.369516
496,nan,,C[C@H]1C/C=C/[C@@H](O)[C@@H](O)CCC(=O)Cc2cc(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:47.390008
497,nan,,C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=N/OCC(=O)N2CCC(O)CC2)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:47.410689
498,nan,,CCCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:47.477362
499,nan,,C[C@@H]1C[C@@H]2O[C@H]2/C=C\C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:47.497752
500,nan,,COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@@H](O)C(=O)/C=C/C[C@H](C)OC2=O,standard_macrolactone,14.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:47.517281
501,CHEMBL273535,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)O[C@H](C)[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL273535_numbered.png,2026-03-19 02:40:47.586091
502,nan,,C=CCO[C@@H]1C[C@@H](C)C(=O)[C@H](C)[C@H]2OC(=O)O[C@]2(C)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)Cc2ccccc2Cl)[C@H](C)[C@H]1OC1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,14.0,,,success,,12.0,"[3, 4, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:47.651707
503,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]2(C)C[C@@H](C)C(=NC(C)=O)[C@H](C)C(OC/C(=N/OCc3ccccc3)CO2)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:47.720586
504,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc4[nH]c(-c5ccccc5Cl)nc4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:47.790492
505,CHEMBL418256,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)cc3)C(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/CHEMBL418256_numbered.png,2026-03-19 02:40:47.860980
506,CHEMBL3828395,,COc1cc(O)c2c(c1)/C=C/CCC[C@@H](O)CCC[C@H](C)OC2=O,standard_macrolactone,14.0,,,failed,non-ring atom 2 marked aromatic,,,ring_size_14/standard/numbered/CHEMBL3828395_numbered.png,2026-03-19 02:40:47.880970
507,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OCCCc2cccnc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N\OCc2ccccc2Cl)[C@H](C)[C@H]2OC(=O)O[C@]12C,standard_macrolactone,14.0,,,success,,13.0,"[3, 4, 4, 5, 6, 7, 8, 10, 10, 11, 12, 13, 14]",ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:47.950041
508,nan,,CC1CCCC(=O)CCCC=Cc2cc(OC(=O)c3ccccc3)cc(OC(=O)c3ccccc3)c2C(=O)O1,standard_macrolactone,14.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_14/standard/numbered/nan_numbered.png,2026-03-19 02:40:47.970281
509,nan,,CC(=O)OC[C@]12[C@H](O)C(=O)[C@@H]3[C@@H](O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1[C@@H](C)[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,14.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
510,CHEMBL1774639,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCN(CCC#N)C(=S)NCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
511,CHEMBL3774592,,C=C1/C=C/C(=O)N(C)CC(=O)N[C@@H]([C@H](O)C(N)=O)C(=O)O[C@@H]([C@H](C)CCCCCCCCCCCCC(C)C)[C@H](C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
512,CHEMBL89179,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCc2cccnc2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
513,CHEMBL89747,,CCOC(=O)N1CCN(C(=O)CNC(=O)[C@@H]2CCCCN(C)C(=O)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N2)CC1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
514,CHEMBL2029743,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2ccc3ccccc3n2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
515,nan,,CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H]2[C@@H](OC(C)=O)[C@@]34O[C@@]2(C)COC(=O)c2cccnc2CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c2ccccc2)[C@H](OC(C)=O)[C@@]13CO)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
516,nan,,CC(C)[C@@H]1OC(=O)C(C)(C)[C@@H](O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](C(C)C)OC(=O)[C@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
517,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCCCc2ccccn2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
518,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
519,nan,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
520,CHEMBL4068622,,C=C1/C=C/C(=O)N[C@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCOC(=O)CP(=O)(OCC)OCC)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
521,nan,,CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)OC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(I)cc2)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
522,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CCC(C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
523,CHEMBL3218564,,CCCC[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)N[C@H](CC(C)C)[C@@H](O)CC(=O)O2,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
524,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(C#CCN(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
525,CHEMBL1774293,,CCNC(=O)N1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
526,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccccc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccncc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
527,nan,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(Cc4ccncc4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
528,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccc(C)cc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
529,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H]3[C@H]2OC(=Nc2ccc(OC)cc2)N3C)[C@](C)(OC)C[C@@H](C)C(=O)N[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
530,nan,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNCCCNCCOCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
531,nan,,CO/C1=C(/C(C)C)CC/C=C(/C)C2OC(C)(O)C3C(=O)O/C(=C(/C)CCC(C)OC1=O)C23,standard_macrolactone,15.0,,,success,,8.0,"[3, 6, 7, 8, 9, 10, 14, 15]",ring_size_15/standard/numbered/nan_numbered.png,2026-03-19 02:40:48.189815
532,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(=O)c3ccccc3)[C@@H]3OC(=O)[C@@H](C)CCc4ncccc4C(=O)OC[C@]4(C)O[C@]1([C@H](O)[C@@H]4[C@@H](OC(C)=O)[C@H]2OC(C)=O)[C@@]3(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
533,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(=O)c1ccccc1)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
534,nan,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]3[C@@H](OC(C)=O)[C@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@H](C)C(=O)O[C@H]([C@@H](OC(=O)c1ccco1)[C@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
535,CHEMBL89034,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCOCC2)CCCCN(C)C(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
536,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CN(CC)CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)N[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
537,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccc(C)cc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(OC)cc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
538,nan,,CC[C@H](C)[C@@H]1OC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)C/C(C)=C\[C@H](C)[C@@H](O)/C(C)=C\[C@@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
539,CHEMBL3601578,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(Cc2ccc(-c3cn(CCn4ccc5cc([N+](=O)[O-])ccc54)nn3)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
540,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCNc3cc4c(=O)c(C(=O)OC(C)C)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
541,nan,,COc1c(Br)cc2cc1Oc1ccc(cc1)CC(O)COC(=O)CC2,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
542,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(OC(C)=O)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
543,CHEMBL553625,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=S)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
544,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3ccc(F)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2Cl)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
545,nan,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)CNCCCNCCOCCOCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
546,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(OC(C)=O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
547,nan,,CC[C@@H]1CCC(=O)O[C@H]2[C@H](C)[C@@]34O[C@](C)(COC(=O)c5cccnc51)[C@@H]([C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]3(COC(C)=O)[C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O)[C@@H]4OC(C)=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
548,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cnccc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccco1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
549,CHEMBL3775644,,C=C1/C=C/C(=O)N(C)CC(=O)N[C@H]([C@@H](O)C(=O)OC)C(=O)O[C@@H]([C@H](C)CCCCCCCCCCCC(C)C)[C@H](C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
550,CHEMBL1682468,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(Cl)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
551,nan,,CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(OC)C[C@@H](C)[C@H](O)[C@H](C)CN(C)C[C@H](COc3ccc(-c4cccnc4)cc3)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
552,nan,,CC(C)C[C@@H]1OC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
553,CHEMBL1682595,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NC2CC3C=CC2C3)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
554,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CN(CCO)CCO)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
555,CHEMBL539222,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=S)NCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
556,CHEMBL313936,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCCc2ccccn2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
557,CHEMBL557551,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
558,CHEMBL553222,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
559,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCc2ccccc2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
560,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCOc3cc4c(=O)c(C(=O)OCOC(=O)C(C)(C)C)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
561,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCO[C@@H]3O[C@H](CO)[C@@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
562,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCCc3cc4c5c(c3)c(=O)c(C(=O)O)cn5C(C)(C)CO4)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
563,CHEMBL3775914,,COC(=O)[C@H](O)[C@H]1NC(=O)CN(C)C(=O)/C=C/[C@@H](CO)NC(=O)[C@H](C)[C@@H]([C@@H](C)CCCCCCCCCCCC(C)C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
564,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@](O)(CNC(C)(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
565,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NC(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
566,CHEMBL431008,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCN(C)CC2)CCCCN(C)C(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
567,nan,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCN2CCN(c3ccc(F)cc3)CC2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
568,CHEMBL315276,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCN(C)CC2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
569,nan,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4cccc(OC)c4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
570,CHEMBL1682576,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccccc2F)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
571,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
572,nan,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4cc5ccccc5[nH]4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
573,CHEMBL1682465,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2cccc3nsnc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
574,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@@]2(O)[C@@H](C)C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(Cl)[C@@H](O)C[C@@]32C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
575,CHEMBL1682451,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2cccc3nsnc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
576,CHEMBL3352926,,C=C1/C=C/C(=O)N(C)CC(=O)NC(C(O)C(N)=O)C(=O)OC(C(C)CCCCCCCCCCCCC(C)C)C(C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
577,CHEMBL350938,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](Cc3ccccc3)NC2=O)cc1Cl,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
578,CHEMBL2029761,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Cc2cccc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
579,nan,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4cccnc4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
580,CHEMBL2029589,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNc2ccnc3cc(Cl)ccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
581,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCCCCNC(=O)c3cc([N+](=O)[O-])cc([N+](=O)[O-])c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccc(F)c(F)c2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
582,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccccc4)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
583,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4ccccc4Cl)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
584,CHEMBL1682453,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc([N+](=O)[O-])cc2OC)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
585,CHEMBL541735,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCN(CCC#N)C(=O)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
586,nan,,O=C1CCc2ccc(O)c(c2)Oc2ccc(cc2)[C@H]2O[C@@H]2CO1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
587,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCCCc2ccccc2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
588,nan,,CCC1OC(=O)C(C)[C@@H](O[C@H]2C[C@@](C)(OC)C(O)C(C)O2)C(C)[C@@H](O[C@@H]2OC(C)CC(N(C)C)C2O)[C@@](C)(O)CC(C)CN(C)C(C)C(O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
589,nan,,C=CCO[C@]1(C)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](OC(=O)CCN(C)CCc2ccccc2)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
590,nan,,CC(C)CC1NC(=O)C(C(C)C)NC(=O)C(CC(C)C)OC(=O)C(CC(C)C)NC(=O)C(Cc2ccccc2)NC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
591,CHEMBL2029585,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCCCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
592,nan,,C=C1CC[C@H](Br)[C@@]2(C)CC[C@@H](Br)[C@@](C)(O)CC[C@@H](C(C)(C)Br)OC(=O)c3ccc(O)c(c3)C[C@H]12,standard_macrolactone,15.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_15/standard/numbered/nan_numbered.png,2026-03-19 02:40:48.697878
593,nan,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccc(Br)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccc(OC)cc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
594,CHEMBL2029749,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNCc2ccnc3ccccc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
595,CHEMBL4072704,,CCCCCC[C@@H](C)[C@@H]1OC(=O)[C@H](C(C)C)NC(=O)[C@@H](C)NC(=O)/C=C/[C@H](CO)NC(=O)[C@H]1CCOCc1ccccc1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
596,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@](O)(CSCCO)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
597,nan,,CO/N=C/C=C/C(=O)N/C=C/C[C@@H]1CC(=O)O[C@@H](CO)/C=C\[C@@H](O)/C(C)=C\Cc2cccc(O)c2C(=O)O1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
598,CHEMBL88906,,CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCC(C(=O)O)CC2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
599,CHEMBL349460,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C(C)C)NC2=O)cc1Cl,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
600,CHEMBL509784,OPPOSITINE A,CCC1CCC(=O)O[C@H]2[C@H](OC(C)=O)[C@H](OC(=O)c3ccccc3)[C@@]3(COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]4[C@@H](OC(C)=O)[C@]3(O[C@]4(C)COC(=O)c3cccnc31)[C@@]2(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
601,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NNC(=O)c3ccc(Cl)cc3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
602,CHEMBL2314758,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@H]2[C@H](C)C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@@]32C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
603,nan,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
604,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CCC(=O)[C@H](C)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
605,CHEMBL1682447,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NC(c2ccccc2)c2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
606,nan,,COc1ccc(C[C@@H](C(=O)O[C@H](C)[C@H](NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](C)O)C(=O)N2CCCCNC(=O)[C@@H](C)C(=O)[C@H](C(C)C)OC(=O)C[C@H](O)[C@H]2CC(C)C)N(C)C(C)=O)cc1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
607,CHEMBL2029591,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNc2cc(C)nc3ccc(OC)cc23)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
608,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3ccc4c(=O)c(C(=O)O)cn(C5CC5)c4c3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
609,CHEMBL1774626,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCNC(=O)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
610,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(=O)c4ccccc4)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@](C)(OC(C)=O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
611,nan,,CC[C@H](C)[C@H]1OC(=O)C(C)(C)[C@H](O)[C@H](Cc2ccccc2)OC(=O)[C@@H](C(C)C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC1=O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
612,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3cccc4ccccc34)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
613,nan,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccc(Cl)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccc(OC)cc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
614,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4N(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
615,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(=O)c1ccoc1)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
616,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](N)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OC(=O)OCC2c3ccccc3-c3ccccc32)[C@](C)(O)C[C@@H](C)N(CCF)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
617,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC(O)CNCCc2cccnc2)C[C@@H](C)NC(=O)[C@H](C)[C@H](O)[C@@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
618,CHEMBL1682607,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)NC(=O)c2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
619,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCN(C)CCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
620,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)NCc3cn(Cc4c(Cl)cccc4Cl)nn3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](OC(=O)NCc2ccccc2)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
621,nan,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(c4ncccn4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)CC(N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
622,CHEMBL3358523,,C[C@H]1CCCC(=O)N(C)/C=C/CC[C@H](C)C(=O)O[C@H](C(C)(C)C)C1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
623,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@H](O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
624,nan,,CCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]3OC(=O)O[C@]3(C)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
625,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](N)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
626,nan,,C/C=C\C/C=C/[C@H](C)C[C@H](O)[C@H]1C[C@@H]2O[C@H]2/C=C\[C@@H](O)[C@@H](O)/C=C\C[C@H](C)CC(=O)O1,standard_macrolactone,15.0,,,success,,6.0,"[3, 5, 6, 9, 10, 14]",ring_size_15/standard/numbered/nan_numbered.png,2026-03-19 02:40:49.006018
627,nan,,CC[C@H]1OC(=O)/C(C)=C\[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)CN(C(=O)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
628,nan,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(CCc4ccc(NC(C)=O)cc4)CC3)O[C@](C)(C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
629,CHEMBL1682459,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(Cl)c(Cl)c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
630,CHEMBL4098570,,C=C1/C=C/C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)O[C@H]([C@@H](C)CCCCCC)[C@@H](CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
631,nan,,CO/N=C/C=C\C(=O)N/C=C/C[C@@H]1CC(=O)O[C@@H](C)/C=C\[C@@H](O)/C(C)=C\Cc2cccc(O)c2C(=O)O1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
632,CHEMBL2029763,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)[C@H](C)c2ccc3cc(OC)ccc3c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
633,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C(=O)Nc2cccc(C(F)(F)F)c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
634,nan,,C/C=C/C/C=C\[C@H](C)C[C@H](O)[C@H]1C[C@@H]2O[C@H]2/C=C\[C@@H](O)[C@@H](O)/C=C\C[C@H](C)CC(=O)O1,standard_macrolactone,15.0,,,success,,6.0,"[3, 5, 6, 9, 10, 14]",ring_size_15/standard/numbered/nan_numbered.png,2026-03-19 02:40:49.094240
635,nan,,C[C@@H]1CC=CCCCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,standard_macrolactone,15.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_15/standard/numbered/nan_numbered.png,2026-03-19 02:40:49.113506
636,CHEMBL1682467,,CCOC(=O)c1ccc(NC(=S)NCCCN2C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]2C)cc1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
637,nan,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)(CN(C)Cc3ccc(-c4cn(CCCCC(=O)NO)nn4)cc3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
638,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)C(=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@@](C)(O)C(=O)O[C@@H]([C@H](OC(C)=O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
639,nan,,C=CCN1C(=O)O[C@H]2[C@H](O[C@@H]3[C@@H](C)[C@H](O[C@H]4C[C@@](C)(OC)[C@@H](O)[C@H](C)O4)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@]3(C)O)O[C@H](C)C[C@@H]21,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
640,CHEMBL1682461,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccc3c(c2)CCC3)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
641,CHEMBL1773086,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
642,CHEMBL3822850,,COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc2ccc3cc(-c4ccc(-c5c[nH]c([C@@H]6C[C@@H]7CN6C(=O)[C@H](C(C)C)NC(=O)OCCC/C=C/CO7)n5)cc4)ccc3c2[nH]1)C(C)C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
643,nan,,CCCNC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
644,nan,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4ccccc4)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
645,nan,,C=C[C@@]1(O)[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
646,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCC(=O)NCCOCCNc3cc4c(cc3F)c(=O)c(C(=O)O)cn4C3CC3)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
647,nan,,CON1O/C=C\C=C(N)/C=C\C[C@@H]2CC(=O)O[C@H](CO)/C=C\[C@@H](O)/C(C)=C\Cc3cccc(c3C(=O)O2)O1,non_standard_macrocycle,15.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
648,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCCNC(=O)CCCNc3ccnc4ccccc34)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
649,CHEMBL1682713,,C=CCNC(=S)NCCCN1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
650,CHEMBL1774291,,C=CCN1C[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
651,nan,,CC(=O)OC[C@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@@H]([C@H](OC(=O)c1ccncc1)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
652,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C(N)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)N(C)C[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
653,CHEMBL3358522,,C[C@@H]1CCCC(=O)N(C)CCCC[C@@H](C)C(=O)O[C@@H](C(C)(C)C)C1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
654,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCNCCNc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
655,nan,,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OCC2CO2)C[C@@H](C)NC(=O)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
656,nan,,CO[C@@H]1COC(=O)[C@H]2CCCN2C(=O)[C@@H](C)COC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
657,CHEMBL4095942,,C=C1/C=C/C(=O)N[C@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]([C@H](C)CCCCCC)[C@H](CCOC(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)N1,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
658,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)Cc3ccc(-c4cn(CCCCCCC(=O)NO)nn4)cc3)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
659,nan,,CC(=O)OC[C@@]12[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]3[C@@H](OC(C)=O)[C@@]14O[C@]3(C)COC(=O)c1cccnc1CC[C@H](C)C(=O)O[C@H]([C@H](O)[C@@H]2OC(C)=O)[C@]4(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
660,CHEMBL1682574,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2cccc(Cl)c2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
661,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)NCCc2ccccc2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@H]2OC(=O)O[C@]12C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
662,CHEMBL1682581,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=O)Nc2ccccc2-c2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
663,nan,,CC#C[C@@]1(O)[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C)C[C@@]1(C)OC,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
664,nan,,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(OC(=O)NNC(=O)/C=C/c3ccco3)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(OC(=O)NCc2ccc(OC)cc2)C1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
665,nan,,CC[C@H]1OC(=O)[C@H](C)[C@H]2OC3(CCN(C(=O)c4c[nH]c5ccccc45)CC3)O[C@](C)(C[C@@H](C)CN[C@H](C)[C@@H](O)[C@]1(C)O)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]2C,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
666,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OCCCOCCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4N(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
667,CHEMBL1946558,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCCNc3ccnc4ccc(Cl)cc34)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
668,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCOCCOc3cc4c(=O)c(C(=O)O)cn(C5CC5)c4cc3Cl)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
669,CHEMBL1682608,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(CCCNC(=S)Nc2ccc(N(CC)CC)cc2)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
670,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](OC(=O)CCCCOCCCc3ccc4c(c3)c(=O)c(C(=O)O)cn4CC)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O,non_standard_macrocycle,15.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
671,nan,,O=C1CCCCCCCCCCC(=NOC(=O)COc2cccc([N+](=O)[O-])c2)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:49.418322
672,nan,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(CC)CC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:49.469746
673,nan,,CC1CCCCCCCCCCCCCOC1=O,standard_macrolactone,16.0,,,success,,1.0,[16],ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:49.492984
674,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2OC(C)=O)[C@@H](CCOc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:49.552572
675,CHEMBL435458,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)c3ccccc3NC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
676,nan,,CCOC(=O)[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)OCCC(/C=C/Cc4cncc5ccccc45)CN(C)C[C@H](O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
677,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCOS(=O)(=O)c2ccc(C)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:49.629166
678,nan,,CC[C@@H]1OC(=O)CCC/C=C\C/C=C\C/C=C\[C@H]2[C@H]1C[C@@H](O)[C@@H]2O,standard_macrolactone,16.0,,,success,,3.0,"[3, 4, 5]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:49.661546
679,nan,,CC(C)[C@@H]1NC(=O)[C@@H](NC(=O)c2ccccc2)[C@@H](C)OC(=O)[C@@H]2CCCCN2C(=O)[C@@H]2CCCCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
680,nan,,O=C1CCCCCCCCC(=O)OCCCCO1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
681,nan,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\[C@H]2O[C@@H]2C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:49.728229
682,CHEMBL328208,,Cc1nc2cc([C@@H]3C[C@@H]4O[C@]4(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O3)ccc2n1C,standard_macrolactone,16.0,,,success,,11.0,"[3, 5, 6, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/CHEMBL328208_numbered.png,2026-03-19 02:40:49.783221
683,nan,,CO[C@H]1[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](O)[C@H](C)C[C@@H](CC=O)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O2)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:49.829878
684,nan,,CCC1CC(C)C(=O)/C=C\C=C/CC(C)OC(=O)CC(O)C(OC)C1OC1OC(C)CC(N(C)C)C1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:49.872986
685,CHEMBL103638,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)/C=C/c3cccc(C)c3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
686,nan,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 10, 11, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:49.929229
687,nan,,CC[C@@H](C)[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CCCCCCCCc2ccc(O)cc2)[C@@H](C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
688,nan,,O=C1CCCCCCCCCCC(=NOC(=O)COc2ccccc2Cl)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:49.959364
689,nan,,CO[C@@H]1[C@@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](OC(C)=O)[C@H](C)O3)[C@H](N(C)C)[C@@H]2O)[C@@H](CC=O)C[C@H](C)[C@@H](O)/C=C\C=C/C[C@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:50.006526
690,nan,,COc1ccc(C[C@H]2NC(=O)/C=C\C[C@@H]([C@H](C)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
691,nan,,C=C1Oc2cc(OC)cc(C(=O)O[C@@H]3COC(=O)C[C@H](N)c4cc(O)c(c(Cl)c4)O[C@@H]4c5ccc3c(Cl)c5C3=CC=C[C@@]34O[C@H]3OC(C)(C)[C@H](N(C)C)[C@H](O)[C@@H]3O)c2NC1=O,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
692,nan,,CO[C@@H]1[C@@H](OC[C@@H]2[C@H](C)OC(=O)CC[C@@H](C)[C@@H](O[C@H]3O[C@@H](C)C[C@@]4(OC(=O)O[C@H]4C)[C@@H]3O)[C@@H](C)C[C@H](C)C(=O)/C=C\[C@@H]3O[C@H]32)O[C@@H](C)[C@@H](O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 5, 6, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:50.076175
693,nan,,CCNCC[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](C)[C@@H](CC)OC(=O)CC(O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:50.127404
694,nan,,CC(C)C[C@@H]1OC(=O)[C@H](C)CNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)/C=C\C[C@@H]([C@H](C)/C=C/c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
695,nan,,CC[C@H](C)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@H](C(C)C)NC(=O)C[C@@H](/C=C/c2ccccc2)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
696,nan,,C/C1=C/C[C@@H](/C(C)=C/c2csc(C)n2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:50.188666
697,nan,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN(C)CCCN(C)C(=O)CNC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:50.239663
698,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C(C)=O)C2O)[C@@H](CC(OC)OC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:50.292451
699,nan,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@@H](C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 10, 11, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:50.340524
700,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc(OC)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:50.392886
701,CHEMBL3317810,,C[C@@]12CSC(=N1)c1csc(n1)CNC(=O)C[C@@H](/C=C/CCS)OC(=O)[C@H](Cc1ccccc1)NC2=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
702,CHEMBL92285,,C/C1=C/C[C@@H](c2ccc3sc(C)nc3c2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/CHEMBL92285_numbered.png,2026-03-19 02:40:50.448671
703,nan,,CC(C)C[C@@H]1NC(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
704,nan,,C/C=C1\NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](C)C[C@@H](C)CCC)[C@@H](C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
705,nan,,C[C@@H]1OC(=O)[C@@H](c2cc(O)cc(O)c2)NC(=O)[C@H](c2cc(O)cc(O)c2)NC(=O)[C@@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]1NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Cl)[nH]1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
706,CHEMBL433337,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](c2ccc(O)cc2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
707,nan,,CC[C@@H]1C[C@@H](C)C(=O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H](OC)[C@@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:50.518800
708,nan,,CO/C1=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H](OC)[C@H]([C@H](C)[C@H](O)[C@H](C)[C@@]2(OC)C[C@@H](O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:50.565168
709,nan,,CO[C@H]1CCCCCCCCC[C@@H](C)OC(=O)CCC1=O,standard_macrolactone,16.0,,,success,,3.0,"[3, 13, 14]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:50.593441
710,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCCl)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:50.650044
711,nan,,C/C(=C\c1csc(C)n1)[C@@H]1CCCCCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)C(O)CC(=O)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:50.697706
712,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:50.754037
713,nan,,C[C@H]1/C=C\CC/C=C\C=C/C/C=C\CCC(=O)O1,standard_macrolactone,16.0,,,success,,1.0,[3],ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:50.776317
714,CHEMBL1531390,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@H](C)C/C(C)=C/C=C/[C@H](OC)[C@H]([C@@H](C)[C@@H](O)[C@H](C)[C@H]2C[C@@H](O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/CHEMBL1531390_numbered.png,2026-03-19 02:40:50.823419
715,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2cc(Cl)cc(Cl)c2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:50.876642
716,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2cccc(N(C)C)c2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:50.930704
717,nan,,CCC[C@@H]1OC(=O)[C@@H](C)[C@@H]2CC[C@H](C[C@@H](C)OC(=O)[C@@H](C)[C@H]3CC[C@H](O3)[C@H]1C)O2,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
718,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=N\OC/C=C/c2cnc3ccccc3c2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:50.989168
719,nan,,COC1C(OCC2C(C)OC(=O)/C=C\C(C)C(OC3OC(C)CC(O)C3O)CCC(C)C(=O)/C=C\C3OC32)OC(C)C(O)C1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 5, 6, 9, 10, 13, 14]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:51.035532
720,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCOc2ccc(C(=O)c3ccccc3)cc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:51.093027
721,CHEMBL42743,TYLOSIN,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/CHEMBL42743_numbered.png,2026-03-19 02:40:51.147070
722,nan,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(=O)/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
723,nan,,CC[C@H]1OC(=O)C[C@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3C[C@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O[C@H]2CC[C@@H](N(C)C)[C@@H](C)O2)/C=C\C(C)=C/[C@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:51.234438
724,nan,,CC[C@@H]1OC(=O)/C=C\[C@H](C)[C@H](O[C@H]2O[C@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@H](C)C[C@@H](C)C(=O)/C=C\C=C/[C@@]1(O)CO[C@H]1O[C@H](C)[C@@H](O)[C@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:51.283749
725,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCO)C[C@@H](C)C(=O)/C=C\[C@@]2(C)O[C@@H]2[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,11.0,"[3, 4, 5, 6, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:51.342475
726,nan,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/[C@@H](O)[C@H](C)C[C@H](CC=O)[C@H](O[C@H]2O[C@@H](C)[C@H](O[C@H]3C[C@@](C)(O)[C@H](OC(=O)CC)[C@@H](C)O3)[C@@H](N(C)C)[C@@H]2O)[C@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:51.390405
727,nan,,C/C1=C/[C@@H](C)C[C@@H](C)[C@@H](Cc2cnco2)OC(=O)/C(C)=C\[C@@H](C)C[C@@H](C)[C@@H](Cc2cnco2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
728,nan,,C/C1=C/[C@H](C)C[C@H](C)[C@H](Cc2cnco2)OC(=O)/C(C)=C\[C@@H](C)C[C@H](C)[C@H](Cc2cnco2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
729,nan,,CCOC(=O)/C=C/C[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](COC2OC(C)C(O)C(OC)C2OC)[C@@H](CC)OC(=O)C[C@@H](OC(=O)Cc2ccc([N+](=O)[O-])cc2)[C@H](C)[C@H]1OC1OC(C)C(O)C(N(C)C)C1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:51.456921
730,nan,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCN2CC(C)CC(C)C2)C[C@@H](C)C(=O)/C=C/[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,11.0,"[3, 4, 5, 6, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:51.517477
731,nan,,COc1ccc(C[C@H]2NC(=O)/C=C\C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
732,nan,,CC[C@H]1OC(=O)C[C@@H](OC(C)=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C\C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:51.583110
733,CHEMBL3251867,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(=O)CC)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/CHEMBL3251867_numbered.png,2026-03-19 02:40:51.632631
734,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C(C)=O)C2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:51.686696
735,nan,,CC1CC(=O)OC(C)C(O)/C=C/C(=O)OC(C)C(O)/C=C/C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
736,CHEMBL3934882,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(C3CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)ncc(F)c2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
737,nan,,CO[C@@H]1[C@@H](O)CC(=O)O[C@H](C)C/C=C\C=C/[C@H](OC(C)=O)[C@H](C)C[C@H](CC=O)[C@H]1O[C@@H]1O[C@H](C)[C@H](O[C@@H]2C[C@@](C)(OC(C)=O)[C@@H](OC(C)=O)[C@@H](C)O2)[C@H](N(C)C)[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:51.749402
738,CHEMBL3244607,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](N(C)C)[C@@H](OC(=O)CCC(=O)O)[C@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)O[C@@H]2C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/CHEMBL3244607_numbered.png,2026-03-19 02:40:51.796327
739,nan,,CC(=O)C[C@@H]1CCC(=O)/C=C\C(=O)O[C@H](CC(C)=O)CC[C@H](O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
740,CHEMBL379989,RHIZOXIN,CO[C@@H](/C(C)=C/C=C/C(C)=C/c1coc(C)n1)[C@@H](C)[C@@H]1C[C@H](O)[C@@]2(C)O[C@@H]2/C=C/[C@@H](C)[C@H]2C[C@H](CC(=O)O2)C[C@@H]2O[C@H]2C(=O)O1,standard_macrolactone,16.0,,,success,,10.0,"[3, 5, 6, 6, 7, 10, 11, 13, 15, 16]",ring_size_16/standard/numbered/CHEMBL379989_numbered.png,2026-03-19 02:40:51.856222
741,nan,,C/C(=C\c1csc(C)n1)[C@@H]1CC2OC(C)(C)OC2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,10.0,"[3, 5, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:51.910215
742,nan,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)/C(C)=C/C)C(C)C)[C@@H](C)OC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(=O)O)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
743,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@@H](C/C=C/C(C)=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC1OC(C)C(O)C(OC)C1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:51.970831
744,CHEMBL2324838,,C=CCOC(=O)C[C@H]1CNC(=O)[C@@H](Cc2ccc(OC)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
745,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](C=O)C[C@@H](C)C(=N\OCCCc2ccc3ncccc3c2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.029902
746,nan,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(=O)C#Cc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
747,nan,,CCCON=C1CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.057832
748,nan,,CO[C@H]1[C@H](OC[C@H]2/C=C/CCC(=O)[C@@](C)(O)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@](O)([C@H](C)O)[C@H]3O)[C@@H](C)/C=C/C(=O)O[C@@H]2C)O[C@H](C)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 9, 10, 10, 12, 13, 14]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.105377
749,nan,,CC1CCCCCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,1.0,[3],ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.126998
750,CHEMBL122232,,CCCC1(CCC)CNC(=O)[C@@H](Cc2ccc(OC)c(Cl)c2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c2ccccc2)OC(=O)[C@H](CC(C)C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
751,nan,,CCC1CC(C)C(O)/C=C/C=C/CC(C)OC(=O)CC(O)C(OC)C1OC1OC(C)CC(O)(C(C)=O)C1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.175593
752,nan,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C/C=C5/OCC[C@@]6(O[C@H]6C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)[C@@H]5O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
753,nan,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](NC3CCCCC3)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.227854
754,CHEMBL3251858,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](N(C)C)[C@@H](OC(C)=O)[C@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)O[C@@H]2C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/CHEMBL3251858_numbered.png,2026-03-19 02:40:52.273327
755,nan,,CCCC/C=C/C(=O)N[C@@H](Cc1cccc(F)c1)C(=O)N[C@@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H]2CC(C)CCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
756,nan,,C/C(=C\c1coc(C)n1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,11.0,"[3, 5, 6, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.333782
757,nan,,CO[C@H]1[C@@H](OC(C)=O)CC(=O)O[C@H](C)C[C@@H]2O[C@@H]2/C=C\[C@H](O)[C@@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@@H]2C[C@](C)(O)[C@H](OC(=O)CC(C)C)[C@@H](C)O2)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.385588
758,nan,,CCC(=O)O[C@H]1CC(=O)O[C@H](C)C/C=C\C=C/[C@H](C)[C@H](C)C[C@H](CC=O)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@@H](N(C)C)[C@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.429166
759,nan,,CO[C@@H]1[C@@H](OC(C)=O)CC(=O)O[C@@H](C)C/C=C\C=C/[C@H](O[C@@H]2C[C@@H](N(C)C)C[C@H](C)O2)[C@H](C)C[C@H](CC=O)[C@H]1O[C@@H]1C[C@H](C)[C@@H](O[C@@H]2C[C@](C)(O)[C@@H](O)[C@H](C)O2)[C@@H](N(C)C)[C@@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.475452
760,CHEMBL3251860,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](N(C)C)[C@@H](OC(=O)CC)[C@H](O[C@@H]3[C@@H](OC)[C@H](OC(C)=O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)O[C@@H]2C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/CHEMBL3251860_numbered.png,2026-03-19 02:40:52.521862
761,nan,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CCN(C)CCCNC)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.573139
762,CHEMBL403900,POLYDISCAMIDE B,CCC(C)(C)[C@H](NC(=O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(Br)cc1)NC(=O)[C@@H](C)NC=O)C(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CS(=O)(=O)O)C(=O)N[C@@H]1C(=O)N(C)[C@@H](CCC(N)=O)C(=O)N[C@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](CC(=O)O)C(=O)O[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
763,nan,,COC(=O)C[C@@H]1C/C=C\C(=O)O[C@H]([C@H](C)[C@@H](OC)/C(C)=C/C=C/C(C)=C/c2coc(C)n2)C[C@H](O)[C@@]2(C)O[C@@H]2/C=C\[C@@H](C)[C@H](O)C1,standard_macrolactone,16.0,,,success,,8.0,"[3, 5, 6, 6, 7, 10, 11, 13]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.634444
764,nan,,CC(/C=C/C=C(\C)[C@H](O)[C@@H](C)[C@H]1C[C@H](O)[C@]2(C)O[C@H]2/C=C\[C@@H](C)[C@H](O)C[C@H](CC(=O)O)C/C=C\C(=O)O1)=C\c1coc(C)n1,standard_macrolactone,16.0,,,success,,8.0,"[3, 5, 6, 6, 7, 10, 11, 13]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.678828
765,nan,,C/C(=C\c1cc(C)ccn1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1,standard_macrolactone,16.0,,,success,,11.0,"[3, 5, 6, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.732185
766,nan,,CC[C@H]1/C=C\[C@@H]([C@@H](O)C=C(C)C)OC(=O)/C(C)=C\[C@@H]2C(=O)NC3=CC(=O)c4c(cc(C)c(O)c4C(=O)CC1)[C@@]32O,standard_macrolactone,16.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.752940
767,nan,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)C(CC=O)C[C@@H](C)[C@@H](O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.799699
768,nan,,CCOC(=O)c1ccc(OCC[C@H]2C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]2O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)cc1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.852788
769,nan,,O=C1CCCCCCCCCCC(=NOCc2c(F)cccc2Cl)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.876405
770,nan,,CC1CCC(NS(C)(=O)=O)CCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.902265
771,nan,,C[C@@H]1NC(=O)[C@H](C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)/C=C/C=C/C=C/C=C/C=C/C(=O)NC2=C(O)CCC2=O)COC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
772,nan,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](OC(=O)CC)CC(=O)O[C@H](C)C[C@H](O)[C@H](N(C)CCCCCCc4ccccc4)/C=C/[C@H](OC(C)=O)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:52.963765
773,nan,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](OC3[C@H](CC=O)C[C@@H](C)[C@@H](O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@@H](OC(=O)CC)[C@@H]3OC)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.008784
774,nan,,CO[C@@H]1[C@@H](OC[C@H]2[C@@H]3O[C@@H]3/C=C\C(=O)[C@](C)(O)CC[C@@H](O[C@H]3O[C@@H](C)C[C@@H](OC)[C@@H]3O)[C@H](C)/C=C\C(=O)O[C@@H]2C)O[C@@H](C)[C@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 5, 6, 9, 10, 10, 13, 14]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.058016
775,nan,,CC(=O)CC1CCC(=O)CCC(=O)OC(CC(C)=O)CCC(=O)CCC(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
776,nan,,O=C1CCCCCCCCCC/C(=N/OC(=O)COc2ccc(Br)cc2Cl)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.085179
777,nan,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCNCC(C)(C)CO)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.134989
778,CHEMBL406149,,CC(C)C[C@@H]1OC(=O)C(C)(C)CNC(=O)[C@@H](n2cccc2)NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]2O[C@@H]2c2ccccc2)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
779,nan,,CO[C@@H]1[C@@H](OC2OC(C)C(OC3CC(C)(O)C(OC(=O)CC(C)C)C(C)O3)C(N(C)C)C2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.186475
780,CHEMBL313330,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)C3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
781,nan,,CC1CCC(=NOC(=O)C(C)Oc2ccc(Cl)cc2)CCCCCCCCCCC(=O)O1,standard_macrolactone,16.0,,,success,,2.0,"[3, 6]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.219488
782,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@H](N(C)C)[C@@H]2O)[C@@H](CC(=O)O)C[C@@H](C)C(=O)/C=C\[C@]2(C)O[C@H]2[C@@H]1C,standard_macrolactone,16.0,,,success,,11.0,"[3, 4, 5, 6, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.278453
783,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC(=O)Nc1ccccc1,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.331010
784,nan,,CCC[C@H]1C[C@@H]2CC[C@@H](O2)[C@H](CC)C(=O)O[C@@H]([C@H](CC)[C@H]2CC[C@@H](C[C@@H](CCC)N(C)C)O2)[C@H](C)[C@@H]2CC[C@@H](O2)[C@@H](CC)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
785,nan,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C(Br)C#Cc3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)CCNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
786,nan,,Cc1nc2c([nH]1)CCCCCCCCC[C@@H](C)OC(=O)/C=C/2,standard_macrolactone,16.0,,,failed,non-ring atom 1 marked aromatic,,,ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.363557
787,CHEMBL251118,,C[C@@]1(N)Cc2cccc(c2)CC[C@H](c2ccccc2)NC(=O)c2cc(Br)cc(c2)COC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
788,CHEMBL350017,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)C[C@@H](C)NC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
789,CHEMBL3808853,,CC1COC(=O)Nc2cccc(c2)CNC(=O)C(Nc2ccc3c(N)nccc3c2)c2ccc1cc2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
790,nan,,CCCC/C=C/C(=O)N[C@@H](Cc1cccc(F)c1)C(=O)N[C@@H]1COC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@@H]2CC(C)CCN2C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
791,nan,,C[C@@H]1CCCCCCCCC[C@H](OC(=O)CCC(=O)O)C(=O)/C=C\C(=O)O1,standard_macrolactone,16.0,,,success,,3.0,"[3, 13, 14]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.419742
792,nan,,COC(/C(C)=C/C=C/C(C)=C/c1coc(C)n1)C(C)C1CC(O)C2(C)OC2C=CC(C)C2CC(CC(=O)O2)CC2OC2C(=O)O1,standard_macrolactone,16.0,,,success,,10.0,"[3, 5, 6, 6, 7, 10, 11, 13, 15, 16]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.471826
793,nan,,CO[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)/C=C\C(=O)O[C@H](C)[C@@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)/C=C\CCC(=O)[C@H](C)C[C@@H]2C)[C@@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.515892
794,CHEMBL3939509,,CCS(=O)(=O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1ccc3c(N)ncc(F)c3c1)c1ccc(c(C)c1)[C@@H](C)COC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
795,nan,,CC[C@H]1OC(=O)CC(O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CCNC2C(O)CCCC2O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1C,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.572889
796,nan,,CC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@@H]2O)[C@H](C)C[C@@H](C)C(=O)/C=C\[C@H]2O[C@@H]2[C@@H]1CO[C@@H]1O[C@H](C)[C@H](O)[C@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 5, 6, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.625955
797,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)C(C=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1COC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.679071
798,CHEMBL4077853,,CCS(=O)(=O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1ccc3cc[nH]c(=O)c3c1)c1ccc(cc1)CCOC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
799,nan,,CC[C@@H]1OC(=O)CCC/C=C\C/C=C\C/C=C\[C@H]2[C@H]1C[C@@H](Cl)[C@@H]2O,standard_macrolactone,16.0,,,success,,3.0,"[3, 4, 5]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.715831
800,CHEMBL3349528,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H](C[C@H]3O[C@@H]3c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
801,nan,,COc1ccc(C[C@H]2NC(=O)/C=C\C[C@@H](C/C=C/c3ccccc3)OC(=O)[C@H](CC(C)C)OC(=O)[C@H](C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
802,nan,,C=C1Oc2cc(OC)cc(C(=O)O[C@H]3COC(=O)C[C@H](N)c4cc(O)c(c(Cl)c4)O[C@@H]4C#C/C=C/3C#CC3=CC=C[C@@]34O[C@@H]3OC(C)(C)[C@@H](N(C)C)[C@@H](O)[C@H]3O)c2NC1=O,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
803,nan,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](C(=O)OCNC(=O)OCC3c4ccccc4-c4ccccc43)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.784867
804,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=N/OCCOc2ccccc2)/C=C/C(C)=C/C1CO,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.834997
805,nan,,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O[C@@H]2CC[C@H](N(C)C)[C@@H](C)O2)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.880817
806,nan,,C[C@H]1CCC(=O)/C=C\C(=O)O[C@H](C)CCC(=O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
807,CHEMBL328224,,C/C1=C/C[C@@H](c2ccc3cccnc3c2)OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC1,standard_macrolactone,16.0,,,success,,9.0,"[3, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/CHEMBL328224_numbered.png,2026-03-19 02:40:53.932537
808,nan,,CC[C@@H]1OC(=O)/C=C\[C@H](C)[C@H](O[C@@H]2O[C@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@@H](C)C[C@H](C)C(=O)/C=C\C=C/[C@@H]1CO[C@@H]1O[C@@H](C)[C@H](O)[C@H](O)[C@@H]1O,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:53.976193
809,CHEMBL3956442,,CC[C@@H](C(=O)O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1ccc3c(N)ncc(F)c3c1)c1ccc(c(C)c1)[C@@H](C)COC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
810,CHEMBL124364,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccccc3)OC(=O)[C@H](CC(C)C)NC(=O)C3(CC3)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
811,nan,,CO[C@@H]1/C=C\C=C(\C)C[C@H](C)[C@H](O)[C@H](C)/C=C(C)\C=C(\C)C(=O)O[C@H]1/C(C)=C/[C@H](C)C1=CC=C(C)[C@H](C(C)C)O1,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:54.033146
812,nan,,O=C1CCCCCCCCCCC2(CCCO1)N=N/C(=N/c1ccc(Br)cc1)S2,standard_macrolactone,16.0,,,success,,2.0,"[6, 6]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:54.059450
813,CHEMBL3917434,,CCN(CC)C(=O)c1ccc2cc1CN(C)C(=O)[C@H](Nc1ccc3c(N)nccc3c1)c1ccc(c(C)c1)[C@@H](C)COC(=O)N2,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
814,nan,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@@H](O)[C@@H](Cl)c3ccc(CN4CCNCC4)cc3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
815,CHEMBL3967204,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1ccc(C3(c4nnn[nH]4)CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)ncc(F)c2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
816,CHEMBL327295,,COc1ccc(C[C@H]2NC(=O)/C=C/C[C@@H]([C@H](C)[C@H]3O[C@@H]3c3ccc(C)c(C)c3)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)CNC2=O)cc1Cl,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
817,nan,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@]5([C@H](C)O)OCC[C@]6(O[C@H]6C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1)[C@H]5O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
818,CHEMBL3251868,,CCCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](OC)[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC(=O)CCC)[C@H](C)C[C@@H]3CC=O)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/CHEMBL3251868_numbered.png,2026-03-19 02:40:54.136636
819,nan,,CC[C@H]1OC(=O)/C=C\[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@@H](N(C)C)[C@@H]2O)CC[C@@H](C)C(=O)/C=C\[C@H]2O[C@@H]2[C@]1(O)CO[C@H]1O[C@@H](C)[C@H](O)[C@@H](OC)[C@@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 4, 5, 6, 9, 10, 13, 14]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:54.186320
820,nan,,CC[C@H](C)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@@H](C(C)C)NC(=O)C[C@H](/C=C/c2ccccc2)OC(=O)[C@@H](C(C)C)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
821,nan,,C/C=C(\NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCN1C(=O)/C(=C/C)NC(=O)CC(O)CCCCC)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCO)C(=O)N[C@H](CCN)C(=O)N[C@@H](CCCCN)C(=O)O[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
822,nan,,C/C=C(\NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCN1C(=O)/C(=C/C)NC(=O)CC(O)CCCCC)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCO)C(=O)N[C@H](CCN)C(=O)N[C@@H](CCCCN)C(=O)O[C@@H]1C,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
823,nan,,CCC(=O)O[C@H]1[C@@H](C)O[C@@H](O[C@H]2[C@@H](N(C)C)C[C@H](O[C@@H]3[C@H](CC=O)C[C@H](C)[C@H](O)/C=C\[C@@H]4O[C@H]4C[C@@H](C)OC(=O)C[C@H](OC(C)=O)[C@@H]3OC)O[C@@H]2C)C[C@]1(C)O,standard_macrolactone,16.0,,,success,,9.0,"[3, 5, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:54.281429
824,nan,,C/C=C1\NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)C=C(C)C)C(C)C)[C@@H](C)OC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(=O)O)NC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
825,CHEMBL3251862,,CCC(=O)O[C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](OC(C)=O)[C@H](OC)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@H]1C,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/CHEMBL3251862_numbered.png,2026-03-19 02:40:54.336366
826,nan,,CCCCCCCCCCCC[C@@H]1CCCCCCCCC(=O)OC[C@H]2O[C@@H](O1)[C@H](OC(C)=O)[C@@H](O)[C@@H]2O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
827,nan,,CCOC(=O)NN(CC[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](CO[C@@H]2O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]2OC)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]1O)C(=O)OCC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:54.395466
828,nan,,CO/C1=C\C(C)=C\[C@@H](C)C(=O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)CC(=O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:54.441607
829,nan,,CC(Oc1ccc(Cl)cc1Cl)C(=O)ON=C1CCCCCCCCCCC(=O)OCCC1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:54.463920
830,nan,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)/C=C(\C)C2=C[C@@H](OC)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:54.509552
831,CHEMBL3977297,,Cc1cc2ccc1[C@@H](C)COC(=O)Nc1cc(F)c(O[C@@H](C)CO)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1,non_standard_macrocycle,16.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
832,nan,,COCCOCCC(=O)NCCCC[C@H]1C(=O)C(C)(C)[C@@H](O)CC(=O)O[C@H](/C(C)=C/c2csc(C)n2)C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@@H]1O,standard_macrolactone,16.0,,,success,,11.0,"[3, 5, 6, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:54.571060
833,nan,,C/C(=C\c1csc(C)n1)[C@@H]1C[C@H](O)[C@@](C)(O)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)C(O)CC(=O)O1,standard_macrolactone,16.0,,,success,,11.0,"[3, 5, 6, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:54.625019
834,nan,,CO[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)/C=C/C(=O)O[C@H](C)[C@@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)[C@@H]3O[C@H]3/C=C/C(=O)[C@@](C)(O)C[C@@H]2C)[C@@H]1O,standard_macrolactone,16.0,,,success,,10.0,"[3, 4, 5, 6, 9, 10, 10, 12, 13, 14]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:54.679034
835,CHEMBL2323287,,CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)-c2nnnn2CC(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
836,nan,,CO[C@@H]1C[C@H](OC(N)=O)[C@@H]2C=C[C@@H]3/C=C(C)\C=C/[C@@H](C)[C@H]([C@H](C)[C@H](O)[C@@H](C)NC(C)=O)OC(=O)/C=C\C=C(C)/C=C\[C@]3(C)[C@@H]2C1,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 7, 9, 10, 10, 13]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:54.729493
837,nan,,C/C=C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C\C=C/[C@@H]2OC)C[C@@H](OC(=O)/C=C/C(=O)NC2=C(O)CCC2=O)[C@@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:54.778292
838,CHEMBL61164,,CC1C/C=C\CCCCCCCCCOC(=O)N1CC(O)C(Cc1ccccc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@@H]12,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
839,nan,,CCC[C@H]1CCCC(=O)N[C@@H](CO)CCC[C@H](C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
840,nan,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(OC)C[C@@H](C(=O)Oc3ccccc3)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:54.838528
841,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CCO)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](O)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:54.891777
842,nan,,O=C1CCCCCCCCCCC(NS(=O)(=O)Cc2ccccc2)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:54.914916
843,nan,,CCC(=O)O[C@@H]1CC(=O)O[C@H](C)C/C=C\C=C/C(=O)[C@H](C)C[C@H](CC=O)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](N(C)C)[C@@H]2O)[C@@H]1OC,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:54.959222
844,nan,,CC[C@H]1C[C@@H](C)C(=O)/C=C/C(C)=C/[C@H](C)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](N(C)C)[C@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:55.010411
845,nan,,CO/C1=C\C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)CC(=O)[C@H](C)[C@@H](C(C)C)O2)OC1=O,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:55.057729
846,CHEMBL3426551,,CO[C@H]1/C=C(/C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O[C@@H]1/C(C)=C/c1csc(C)n1,standard_macrolactone,16.0,,,success,,10.0,"[3, 4, 6, 10, 11, 12, 13, 14, 14, 15]",ring_size_16/standard/numbered/CHEMBL3426551_numbered.png,2026-03-19 02:40:55.109211
847,nan,,O=C1CCCCCCCCCCC(=NOC(=O)COc2ccc(Cl)cc2Cl)CCCO1,standard_macrolactone,16.0,,,success,,1.0,[6],ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:55.133258
848,nan,,CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]2OC(C)=O)[C@@H](CCOc2ccccc2)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:55.193169
849,nan,,C[C@H]1C[C@H](C)[C@H](O[C@@H]2O[C@H](C)C[C@](O)([C@H](C)O)[C@H]2O)[C@@H](C)/C=C\C(=O)O[C@H](C)[C@@H](C)/C=C\C=C/C1=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 4, 9, 10, 12, 13, 14]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:55.235203
850,CHEMBL100279,,COc1ccc(/C=C/[C@@H](C)[C@@H]2C/C=C/C(=O)N[C@H](Cc3ccc(OC)c(Cl)c3)C(=O)NCC(C)(C)C(=O)O[C@@H](CC(C)C)C(=O)O2)cc1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
851,nan,,C[C@H]1CC[C@@H](O)/C=C\C(=O)O[C@@H](C)CC[C@@H](O)/C=C\C(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
852,nan,,CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@H](CC=O)C[C@@H](C)[C@@H](OC(C)=O)/C=C\C=C/C[C@@H](C)OC(=O)C[C@@H](OC(=O)CC)[C@@H]3OC)[C@H](O)[C@H]2N(C)C)C[C@@]1(C)OC(C)=O,standard_macrolactone,16.0,,,success,,7.0,"[3, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:55.292462
853,nan,,COC(=O)[C@H]1[C@@H](C)C/C(C)=C/C=C/[C@H](OC)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC)[C@H](C)[C@@H](C(C)C)O2)OC(=O)/C(OC)=C/C(C)=C/[C@H]1C,standard_macrolactone,16.0,,,success,,8.0,"[3, 4, 8, 10, 11, 12, 14, 16]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:55.339003
854,CHEMBL3628320,,CCCCCCCCSSCC/C=C/[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N[C@H](C)C(=O)N[C@H](C(C)C)C(=O)NCC(=O)O1,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
855,nan,,CC[C@H]1C[C@@H](C)C(=O)/C=C\C(C)=C/[C@H](C)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@H]1O[C@H](C)[C@H](O)[C@H](O)[C@@H]1O,standard_macrolactone,16.0,,,success,,9.0,"[3, 4, 6, 9, 10, 12, 13, 14, 15]",ring_size_16/standard/numbered/nan_numbered.png,2026-03-19 02:40:55.393789
856,nan,,C/C=C1\NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](C)C[C@@H](C)CCC)[C@H](C)OC1=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
857,CHEMBL394224,,CN(c1cc2cc(n1)N(CC1CC1)CCCCc1cccc(c1)C[C@@](C)(N)C(=O)OC2)S(C)(=O)=O,non_standard_macrocycle,16.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
858,nan,,CCCCCCCC(=O)OCC/C=C/[C@H](Cl)[C@H](O)[C@@H]1OC(=O)/C=C\C=C/c2nc(oc2C)/C=C(/C)CC[C@H]2O[C@H]2[C@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
859,nan,,CC(C)C[C@@H]1NC(=O)OC(CCCc2ccccc2)CCCCCNC(=O)CC[C@@H](C(O)S(=O)(=O)O)NC1=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
860,CHEMBL4097169,,CC(C)C[C@@H]1NC(=O)OC(c2cccc(Cl)c2)CCCCCNC(=O)CC[C@@H](C=O)NC1=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
861,nan,,CCNC1CC2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C(CO)=C(/C)CCc4ccnc6c4CCC(NC)N6)C5=O)C(=O)OCC1CC23,standard_macrolactone,17.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_17/standard/numbered/nan_numbered.png,2026-03-19 02:40:55.446185
862,nan,,O=C1O[C@@H]2[C@@H](COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c4oc(=O)c5c(ccc6oc(=O)c3c4c65)-c3c1cc(O)c(O)c3O)O[C@@H](O)[C@H](O)[C@H]2O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
863,nan,,CCCCCCCC(=O)OCC/C=C/[C@H]1O[C@H]1[C@H]1OC(=O)/C=C\C=C/C(=O)NC(=O)/C=C(/C)CC[C@@H]2O[C@@H]2[C@@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
864,nan,,COc1c(OC(C)C)cc2cc(O)c(C(=O)NC3Cc4ccc(c(Cl)n4)O[C@@H]4C=C5C#C/C(=C\C#CC6OC56C4OC4CC(C)(O)C(O)C(C)O4)C(OC4CC(O)C(N(C)C)C(C)O4)COC3=O)cc2c1OC,non_standard_macrocycle,17.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
865,nan,,CCNC1C=C2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C(CO)=C(/C)CCc4ccnc6c4CCC(NC)N6)C5=O)C(=O)OC(CCCO)C1CC23,standard_macrolactone,17.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_17/standard/numbered/nan_numbered.png,2026-03-19 02:40:55.490524
866,CHEMBL3628304,,CC(C)[C@H]1NC(=O)C[C@H]2/C=C/CCSSC[C@@H](NC1=O)C(=O)N[C@H](C(C)C)c1cn(nn1)CC(=O)O2,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
867,nan,,CCCCCCCC(=O)OCC/C=C/[C@@H](O)[C@@H](O)[C@H]1OC(=O)/C=C\C=C/[C@@](OC)(C(C)=O)NC(=O)/C=C(/C)CC[C@H]2O[C@@H]2[C@@H]1OC(=O)NC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
868,nan,,C#CCCC[C@@H]1OC(=O)CCNC(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)C1(C)C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
869,CHEMBL2323285,,CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)-c2nnn(n2)CC(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
870,nan,,CCCC(=O)N[C@@H](CC(C)C)[C@@H](CC(=O)O[C@@H]1COC(=O)c2csc(n2)[C@H](C(C)C)OC(=O)[C@@H](C)[C@H](CCCC(C)(Cl)Cl)OC(=O)c2csc1n2)OC(C)=O,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
871,nan,,CS[C@H]1SC[C@H](N(C)C(=O)[C@H](C)NC(=O)[C@@H](CO)NC(=O)c2cnc3ccccc3n2)C(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@@H](NC(=O)c2cnc3ccccc3n2)C(=O)N[C@@H](C)C(=O)N(C)[C@@H]1C(=O)N(C)[C@H](C(=O)O)C(C)C,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
872,nan,,CC[C@H]1/C=C\[C@@H](O)[C@@H](C)OC(=O)/C(C)=C\[C@H]2C(=O)NC3=CC(=O)c4c(cc(C)c(O)c4C(=O)CC1)[C@]32O,standard_macrolactone,17.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_17/standard/numbered/nan_numbered.png,2026-03-19 02:40:55.554841
873,nan,,CC[C@H]1/C=C\[C@@H](O)[C@@H](C)OC(=O)/C(C)=C\[C@@H]2C(=O)NC3=CC(=O)c4c(cc(C)c(O)c4C(=O)CC1)[C@]32O,standard_macrolactone,17.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_17/standard/numbered/nan_numbered.png,2026-03-19 02:40:55.576589
874,nan,,C/C=C(C)/C=C(\C)C(O)C(C)[C@H](O)[C@@H](O)[C@H]1C/C=C\C=C\[C@H](O)C[C@@H](O)[C@H](C)c2nc(cs2)/C=C(\CCCCCC)C(=O)O1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
875,CHEMBL2323289,,CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)-c2cn(nn2)CC(=O)N[C@@H](C(C)C)C(=O)O1,non_standard_macrocycle,17.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
876,nan,,CCNC1C=C2C=CCC3CCCCC(C)(Cc4ccc(N)nc4)Cc4cccc5c4C(=O)C4(OC4(C/C(CO)=C(/C)CCc4ccnc6c4CCC(NC)N6)C5=O)C(=O)OCC1CC23,standard_macrolactone,17.0,,,failed,non-ring atom 0 marked aromatic,,,ring_size_17/standard/numbered/nan_numbered.png,2026-03-19 02:40:55.612018
877,nan,,CC(O)C1/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5O[C@]5(C)CC[C@]4(COC(=O)C4OC4(C)C(O)CO1)[C@]2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
878,nan,,CC(C)[C@@H]1OC(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
879,nan,,CC(=O)O[C@H]1CC(=O)OCC2=C3C[C@H]4[C@](O)(COC(=O)/C(C)=C\COC1=O)[C@H]1C[C@H]1[C@]4(C)[C@@H]1C[C@@]4(O)C5=C(C6=C(C)C(=O)O[C@]6(O)C(=O)[C@@]5(C)[C@@H]5C[C@@H]54)[C@]31OC2=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
880,nan,,C/C1=C/C(C)CC(C)OC(=O)C(C)NC(=O)C(Cc2ccc(O)c(I)c2)N(C)C(=O)CNC(=O)C(C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
881,nan,,CC(C)C[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
882,nan,,CC(=O)O[C@@]1(C)CC(=O)OC[C@]23CCC(C)=C[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C/[C@@H]([C@H](C)O)OC[C@H]1O)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
883,nan,,CC1=C2[C@@H]3[C@]45OC(=O)C6=C4C[C@H]4[C@](O)(COC(=O)/C=C(/C)COC(=O)CCC(=O)OC6)[C@H]6C[C@H]6[C@]4(C)[C@@H]5C=C4[C@H]5C[C@H]5[C@](C)(C(=O)[C@@]2(O)OC1=O)[C@@]43O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
884,nan,,C/C1=C/Cc2ccc([nH]2)C2=N[C@@H](/C=C3C(=C(\C)CCCO)/CO[C@H]/3CC(C)C)[C@@H](COC(=O)[C@@H](CC(C)C)CC(=O)O[C@@H]3[C@@H]1OC(=O)[C@]3(C)CO)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
885,nan,,COc1ccc2cc1C(=O)OC[C@H]1O[C@H](Oc3cc4c(c(OC)c3C)C(=O)C[C@H](O4)c3ccc(OC)c-2c3)[C@H](OC)[C@H](OC)[C@H]1OC,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
886,nan,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
887,CHEMBL578929,,CC1CC(C)CC(C)C(O)C(C#N)=CC=CCC(C2CCCC2C(=O)O)OC(=O)CC(O)C(C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/CHEMBL578929_numbered.png,2026-03-19 02:40:55.724530
888,nan,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)OCc2cn(-c3cnc4ccccc4c3)nn2)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/nan_numbered.png,2026-03-19 02:40:55.770342
889,nan,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@H](/C=C/[C@@H]3CC(C)=CCO3)O[Si](C)(C)C(C)(C)C)C[C@@H]3O[C@H]3[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
890,nan,,CC(C)/C=C/C=C/C[C@@H]1NC(=O)[C@H]2C[C@@H](O)CNN2C(=O)COC(=O)[C@](C)(CO)NC(=O)[C@H]2C[C@H](O)CNN2C(=O)[C@H]2C[C@H](Cl)CNN2C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
891,nan,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@@H]3CC(C)=CC(=O)O3)C[C@@H]3O[C@H]3[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
892,nan,,C[C@@H]1CCCCCCCCCC[C@H](O)[C@@H](O)[C@@H](O)/C=C\C(=O)O1,standard_macrolactone,18.0,,,success,,4.0,"[3, 14, 15, 16]",ring_size_18/standard/numbered/nan_numbered.png,2026-03-19 02:40:55.821415
893,nan,,C[C@@H]1CCCCCCCCCC[C@H](O)[C@@H](O)[C@@H](O)CCC(=O)O1,standard_macrolactone,18.0,,,success,,4.0,"[3, 14, 15, 16]",ring_size_18/standard/numbered/nan_numbered.png,2026-03-19 02:40:55.852450
894,CHEMBL221540,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@H](C)[C@H](C)C(=O)O)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/CHEMBL221540_numbered.png,2026-03-19 02:40:55.896530
895,nan,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(N)=O)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/nan_numbered.png,2026-03-19 02:40:55.941839
896,nan,,CCC(C)C1C(=O)OC(C(C)C)C(=O)N(C)C(C(C)CC)C(=O)OC(C(C)C)C(=O)N(C)C(C(C)CC)C(=O)OC(C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
897,CHEMBL4095773,,CC1=C2C3=C4[C@](O)(C[C@H]5[C@@]6(C)[C@@H]7C[C@@H]7[C@@]7(O)COC(=O)/C=C(\C)COC(=O)CCC(=O)OCC8=C(C[C@@H]76)[C@@]35OC8=O)[C@H]3C[C@H]3[C@]4(C)[C@@H](O)[C@@]2(O)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
898,CHEMBL1611678,,CO[C@@H]1COC(=O)[C@H]2CCCN2C(=O)[C@@H](C)COC(=O)[C@H](COCc2ccccc2)NC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
899,nan,,C[C@@H]1CCOC(=O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H](Br)[C@](C)(O)CC[C@]4(COC(=O)[C@H]1O)[C@]2(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
900,nan,,CC1=CC2OC3CC4OC(=O)/C=C\C=C\C(=O)OCCC(C)C(O)C(=O)OCC2(CC1O)C4(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
901,CHEMBL2206980,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(OCc4ncn(C)n4)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
902,CHEMBL2206969,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(NC)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
903,nan,,C=C1C[C@@H](CCC)OC(=O)[C@@H](C)CCCC[C@@H]2O[C@@H](CC(=O)[C@@H](O)[C@H](C)C1)C[C@@H]2C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
904,nan,,CC1=C2C3=C4[C@](O)(C[C@H]5[C@@]6(C)[C@@H]7C[C@@H]7[C@@]7(O)COC(=O)/C(C)=C\COC(=O)CCC(=O)OCC8=C(C[C@@H]76)[C@@]35OC8=O)[C@H]3C[C@H]3[C@]4(C)[C@@H](O)[C@@]2(O)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
905,nan,,CC1=C2C3=C4[C@](O)(C[C@H]5[C@@]6(C)[C@@H]7C[C@@H]7[C@@]7(O)COC(=O)/C(C)=C/COC(=O)CCC(=O)OCC8=C(C[C@@H]76)[C@@]35OC8=O)[C@H]3C[C@H]3[C@]4(C)[C@@H](O)[C@]2(O)OC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
906,CHEMBL1672606,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCc1cc3c(nccc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
907,nan,,CC(C)CCCCCCCCCCCC[C@@H]1O[C@H]2O[C@@H](COC(=O)[C@H](C)[C@@H](CCCCCCCCCCCC(C)C)O[C@@H]3O[C@H](COC(=O)[C@H]1C)[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@@H](O)[C@@H]2O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
908,nan,,C/C=C(C)/C=C(\C)C[C@H](C)[C@H](O)[C@@H]1OC(=O)/C(C)=C\c2csc(n2)[C@@H](CO)[C@@H](O)C[C@H](O)/C=C\C=C/C[C@H]1O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
909,nan,,CC[C@H](C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
910,nan,,CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@](C)(C(=O)[C@H](O)C1=C(C)C3C[C@@](O)([C@H](C)OC(=O)CC/C=C\CCC(=O)N[C@@H](c4ccccc4)[C@@H](O)C(=O)O3)C1(C)C)C2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
911,nan,,CC1=C[C@@H]2O[C@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC/C(C)=C\C(=O)OC[C@]2(CC1)[C@@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
912,CHEMBL4065225,,CC(C)C[C@@H]1NC(=O)OC(c2cccc(Cl)c2)CCCCCONC(=O)CC[C@@H](C=O)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
913,nan,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/C(=O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
914,nan,,C=C1C[C@H](C)C(=O)[C@@H](O)C[C@H]2C[C@H](C)[C@H](CCCC[C@H](C)C(=O)O[C@H](CCC)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
915,CHEMBL1365512,,Cc1ccc(S(=O)(=O)N[C@H]2COC(=O)C/C=C/[C@@H](C)[C@H]3C=C[C@H](O)[C@@H](COC(=O)C/C=C/[C@H]2C)O3)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
916,nan,,CC(C)[C@@H]1OC(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
917,CHEMBL3355648,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)O)C/C=C/C=C(/CN)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/CHEMBL3355648_numbered.png,2026-03-19 02:40:56.126310
918,nan,,CC[C@H](C)[C@H]1OC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC(=O)[C@H](CC(C)C)OC(=O)C(C)(C)C(=O)[C@@H](CC(C)C)NC1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
919,nan,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccc(O)c(Br)c2)N(C)C(=O)CNC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
920,CHEMBL2426331,,CO[C@@H]1C(=O)O[C@H](C)[C@H](C)/C=C(\C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1ccc(N)cc1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
921,nan,,CC1CCOC(=O)/C=C/C=C\C(=O)O[C@@H]2C[C@H]3O[C@@H]4[C@@H]5O[C@]5(C)CC[C@]4(COC(=O)C1O)[C@]2(C)C31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
922,nan,,C/C=C/[C@H]1O[C@@](O)([C@@H](C)[C@H](O)[C@H](C)[C@@H]2OC(=O)/C(OC)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@@H](CC)[C@@H](O)[C@H](C)C/C(C)=C\C=C/[C@H]2OC)C[C@@H](O)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/nan_numbered.png,2026-03-19 02:40:56.205564
923,nan,,CCCC[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](C(C)CC)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](CCCC)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
924,nan,,C/C=C/C(=O)O[C@H]1C[C@@]23COC(=O)[C@@H](O)[C@H](C)CCO[C@@H]([C@H](C)O)/C=C\C=C\C(=O)O[C@@H]4C[C@@H](O[C@@H]2C=C1C)[C@@]1(CO1)[C@]43C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
925,nan,,C=C1C[C@@H](CCC)OC(=O)[C@@H](C)CCCC[C@@H]2O[C@@H](C[C@H](O)C(=O)[C@H](C)C1)C[C@@H]2C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
926,nan,,C=C1C[C@H]2C/C=C\[C@@H](O)[C@@H](C)/C(C)=C\C(=O)O[C@H](C[C@@H](C)[C@H](C)O)[C@@H](C)C/C=C\[C@@](C)(O)[C@@](O)(C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
927,nan,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](CO)NC(=O)[C@@H](Cc2ccc(O)c(I)c2)N(C)C(=O)CNC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
928,nan,,C=C1C[C@@H](CC[C@H](C)O)OC(=O)[C@@H](C)CCCC[C@@H]2O[C@H](C[C@@H]2C)C[C@@H](O)C(=O)[C@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
929,nan,,C[C@H]1CC(=O)OC[C@@]23CC[C@@]4(C)O[C@H]4[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OC[C@H]1O)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
930,nan,,CC1=C[C@@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC[C@@]5(C)O[C@@H]5C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
931,nan,,C=C1C[C@H](C)C[C@@]2(C)CC=C[C@H](C/C=C\C(=O)O[C@H]([C@@H](O)/C=C/[C@H]3CC(C)=CCO3)C[C@@H]3O[C@H]3[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
932,nan,,COC(=O)/C(C)=C1\C(=O)[C@@H](O)[C@@]2(C)C3=C([C@@H](O)[C@@H]4[C@@]5(OC(=O)C6=C5C[C@@H]5[C@@](O)(COC(=O)/C=C(/C)COC(=O)CCC(=O)OC6)[C@@H]6C[C@@H]6[C@]54C)[C@@H]31)[C@@H]1C[C@@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
933,nan,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C\C(=O)OCC/C(C)=C/C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
934,CHEMBL1672596,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCOCC1)NC(=O)OCCC/C=C/c1ccc3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
935,nan,,COC(=O)/C(C)=C1\C(=O)[C@H](O)[C@]2(C)C3=C(C[C@@H]4[C@]5(OC(=O)C6=C5C[C@H]5[C@](O)(COC(=O)/C(C)=C\COC(=O)CCC(=O)OC6)[C@H]6C[C@H]6[C@]45C)[C@H]31)[C@H]1C[C@H]12,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
936,nan,,CC(C)C[C@H]1C(=O)O[C@H](Cc2ccccc2)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
937,nan,,C=C1C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2ccc(O)c(Cl)c2)C(=O)N[C@@H](C)C(=O)O[C@@H](C)C[C@@H](C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
938,nan,,CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)/C=C\C=C/[C@@H]([C@H](C)O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]2(CC1)[C@]4(C)[C@@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
939,CHEMBL154035,,C=C1C[C@H](O)/C=C/C[C@@H]([C@@H](O)/C=C/[C@@H]2CC(C)=CCO2)OC(=O)/C=C/C[C@@H]2C=CC[C@@H](C[C@@H](C)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
940,nan,,CC(C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)O[C@H](C(C)C)C(=O)N1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
941,nan,,C=C1C[C@@H]2C/C=C\[C@H](O)[C@H](C)/C(C)=C\C(=O)O[C@H](CC[C@@H](C)[C@H](C)O)[C@@H](C)C/C=C\[C@@](C)(O)[C@](O)(C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
942,nan,,C[C@@H]1C[C@H](C)[C@@H](O)CC(=O)O[C@H]([C@@H]2CCC[C@H]2C(=O)OCc2cn(C34CC5CC(CC(C5)C3)C4)nn2)C/C=C/C=C(/C#N)[C@H](O)[C@@H](C)C[C@H](C)C1,standard_macrolactone,18.0,,,success,,8.0,"[3, 8, 9, 10, 12, 14, 16, 17]",ring_size_18/standard/numbered/nan_numbered.png,2026-03-19 02:40:56.369999
943,nan,,CC=C[C@H]1O[C@@](O)([C@H](C)C(O)C(C)[C@@H]2OC(=O)C(OC)=CC(C)=C[C@H](C)[C@H](O)[C@H](CC)[C@H](O)C(C)CC(C)=CC=C[C@H]2OC)C[C@@H](O[C@@H]2C[C@H](O)[C@@H](OC(N)=O)[C@H](C)O2)[C@@H]1C,standard_macrolactone,18.0,,,success,,10.0,"[3, 4, 8, 10, 11, 12, 13, 14, 16, 18]",ring_size_18/standard/numbered/nan_numbered.png,2026-03-19 02:40:56.423516
944,CHEMBL1414358,,CO[C@H]1COC(=O)[C@@H](CCSC)NC(=O)C/C=C\[C@@H](C)COC(=O)[C@@H](OCc2ccccc2)/C=C\[C@@H]1C,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
945,CHEMBL398304,BEAUVERICIN G2,CC[C@H]1OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](CC)OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](Cc2ccccc2)N(C)C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
946,CHEMBL347678,,C=C1C[C@H](C)C[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H]([C@H](/C=C/[C@@H]3CC(C)=CCO3)OC(C)=O)C[C@@H]3O[C@H]3[C@@H](OC(C)=O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
947,nan,,CO[C@@]12OC(=O)C(C)=C1C1=C3[C@](O)(C[C@H]4[C@@]5(C)[C@@H]6C[C@@H]6[C@@]6(O)COC(=O)/C=C(/C)COC(=O)CCC(=O)OCC7=C(C[C@@H]65)[C@@]14OC7=O)[C@H]1C[C@H]1[C@]3(C)[C@H]2O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
948,nan,,C=C1[C@@H](OC)C/C=C\[C@@H](O[C@@H]2O[C@H](OC)[C@@H](O)[C@H](OC)[C@H]2O)CC(=O)O[C@@H](/C=C(/C)C/C=C/C)C/C=C\C=C/C[C@H](C)[C@@H]1OO,standard_macrolactone,18.0,,,success,,6.0,"[3, 10, 11, 12, 13, 17]",ring_size_18/standard/numbered/nan_numbered.png,2026-03-19 02:40:56.490165
949,nan,,C/C1=C\C(=O)OC[C@]23CCC(CO)=C[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C\[C@H]([C@@H](C)O)OCC1)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
950,nan,,CC(C)/C=C/C=C/C[C@@H]1NC(=O)[C@H]2C[C@@H](O)CNN2C(=O)COC(=O)[C@](C)(CO)NC(=O)[C@@H]2C[C@H](O)CNN2C(=O)[C@H]2C[C@H](Cl)CNN2C1=O,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
951,CHEMBL2206973,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc(O)nc3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
952,CHEMBL2206982,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1CCCCC1)NC(=O)OCC(C)(C)CCCc1cc3c(cc4nccn4c3cc1OC)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
953,nan,,CC1=C[C@@H]2O[C@H]3[C@@H](O)[C@H]4OC(=O)/C=C\C=C/[C@H]([C@H](C)O)OCC/C(C)=C\C(=O)OC[C@]2(CC1)[C@@]4(C)[C@]31CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
954,nan,,C/C1=C\C(=O)OC[C@]23CC[C@]4(C)O[C@H]4[C@H]2O[C@@H]2C[C@@H](OC(=O)/C=C\C=C\[C@H]4O[C@H](C1)O[C@@H]4C)[C@@]3(C)[C@]21CO1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
955,nan,,C=C1CCC[C@@H]2CC=C[C@@H](C/C=C\C(=O)O[C@H](CO)C/C=C/[C@@H](O)C1)O2,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
956,nan,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,18.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
957,CHEMBL1076535,PALMYRAMIDE A,CCC[C@H]1OC(=O)[C@H](C(C)C)NC(=O)[C@@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)OC(=O)[C@H](C)OC(=O)C1(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
958,nan,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
959,nan,,C=CCCC[C@@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)OC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
960,nan,,CC[C@H](C)C[C@H](C)C[C@@H](C)/C=C(\C)[C@@H]1O[C@](O)([C@](C)(O)C(=O)N[C@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)CC(=O)N(C)CC(=O)NCC(=O)N(C)CC(=O)O[C@@H]2C(C)C)CC[C@H]1OC,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
961,nan,,CC[C@H](C)[C@]1(C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
962,nan,,CC[C@H](C)[C@@H]1NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)CNC(=O)CCCC(C)C)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
963,nan,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(O)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
964,nan,,CC[C@H](C)C[C@H]1CC[C@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@@H]3C(=O)N(OC)[C@@H](C)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(C)[C@H](C)C(=O)O[C@H]2C(C)C)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
965,nan,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
966,nan,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2[C@@H](C)CCN2C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H]([C@@H](C)CC)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
967,nan,,C=C1C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@@H](c2ccc(O)cc2)CC(=O)O[C@@H](C)C[C@@H](C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
968,nan,,CC(C)CCCCC(C)(C)CCC[C@@H]1CC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
969,nan,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
970,nan,,C/C=C/C1CC2C(=O)OC(C)C(NC(=O)C(CC3CC3[N+](=O)[O-])NC(=O)c3ccc(Cl)n3O)C(=O)NC(C(C)c3ccccc3)C(=O)NC(CC3CC3[N+](=O)[O-])C(=O)NC(C(C)c3ccccc3)C(=O)NC(C(C)CC)C(=O)N2C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
971,nan,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](O)COS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
972,nan,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](O)Cc2ccc(O)cc2)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
973,nan,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
974,nan,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)[O-])OC)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
975,nan,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)CCCC(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
976,nan,,C=CC[C@@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
977,CHEMBL2204319,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCC/C=C/c1ccc3ccnc(c3c1)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
978,nan,,CC(C)[C@@H]1NC(=O)[C@@H]2CSCSC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)c3cnc4ccccc4n3)COC1=O)C(=O)N[C@@H](C(C)C)C(=O)OC[C@@H](NC(=O)c1cnc3ccccc3n1)C(=O)N[C@@H](C)C(=O)N2,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
979,nan,,CCCCCC[C@@H]1CC[C@@](O)([C@](C)(O)C(=O)N[C@@H]2C(=O)N3NCCC[C@H]3C(=O)N(O)[C@@H](COC)C(=O)NCC(=O)N3NCCC[C@H]3C(=O)N(O)[C@H](C)C(=O)O[C@@H]2C)O[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
980,nan,,O=C1CCCCCCCCCCC(=O)OCCOCCO1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
981,nan,,CCC[C@H]1NC(=O)c2csc(n2)[C@H](C)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C)OC(=O)[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
982,nan,,C/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C2C(=O)OCCc3ccc(cc3)Oc3cc(ccc3O)CCOC(=O)C[C@H]21,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
983,nan,,CCC[C@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
984,nan,,CC[C@@H]1NC(=O)[C@@H](C)C/C(C)=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
985,nan,,CC(C)[C@H]1C(=O)OC[C@@H](NC(=O)c2cnc3ccccc3n2)C(=O)N[C@@H](C)C(=O)N(C)[C@H]2CSCSC[C@@H](C(=O)N1C)N(C)C(=O)[C@H](C)NC(=O)[C@H](NC(=O)c1cnc3ccccc3n1)COC(=O)[C@H](C(C)C)N(C)C2=O,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
986,nan,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
987,nan,,C/C=C\C=C\C=C/C=C/C=C\C=C/C=C/C=C/C(=O)N(C)[C@@H]1C(=O)N[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
988,nan,,C/C=C1\NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](CCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
989,nan,,C/C=C1\NC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
990,nan,,C/C1=C/[C@@H](O)C[C@H](C)CCO[C@@H]2O[C@H](CO[C@@H]3OC[C@](O)(COC1=O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
991,nan,,CCCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]2CC[C@@H](O)N(C2=O)[C@@H]([C@@H](C)O)C(=O)N(C)[C@@H](Cc2ccc(O)c(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C)[C@@H](C)O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
992,nan,,CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCCN(C)C)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
993,nan,,C/C=C1/[C@H](O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O[C@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3O)[C@@H]2O)OC=C2C(=O)OCCc3ccc(cc3)Oc3cc(ccc3O[C@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3O)CCOC(=O)C[C@@H]21,non_standard_macrocycle,19.0,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
994,nan,,C=CC[C@@H]1/C=C(/C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H]([C@@H](C)[C@H](O)/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)CC1=O)[C@H](C)C[C@@H]2OC,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
995,CHEMBL1532000,,CO[C@@H]1COC(=O)[C@H]2CCCN2C(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)CCC[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
996,nan,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
997,CHEMBL1159823,PROTEOLYTIC ENZYME INHIBITOR,CC(C)C[C@H]1C(=O)N(C)[C@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](O)COS(=O)(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]2CC[C@H](O)N1C2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
998,nan,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
999,nan,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1000,CHEMBL3823434,,COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc2ccc3cc(-c4ccc5c(c4)OCCCCCCOC(=O)N[C@@H](C(C)C)C(=O)N4CCC[C@H]4c4ncc-5[nH]4)ccc3c2[nH]1)C(C)C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1001,nan,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(F)(F)F)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1002,nan,,CC(C)[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCCCN=C(N)N)[C@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@H](C)O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1003,CHEMBL402405,MICROPEPTIN T2,CCCCCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](Cc2ccccc2)C(=O)N(C)[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1004,nan,,CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1005,nan,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)c2ccc(C)cc2)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1006,nan,,COc1cc(O)c2c(c1)/C=C/CC(=O)NCCCCNC(=O)CCC[C@H](C)OC2=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1007,nan,,CC(C)CC1CCC(O)(C(C)(O)C(=O)NC2C(=O)N3NCCCC3C(=O)N(O)C(C)C(=O)N(C)C(Cc3ccccc3)C(=O)N3NCCCC3C(=O)NC(CO)C(=O)OC2C(C)C)OC1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1008,nan,,C/C(Br)=C\[C@@H]1Cc2nc(cs2)CCCCC(=O)O[C@@H](C)C/C(C)=C/C=C/C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1009,nan,,CO[C@@H]1/C=C\C=C/C[C@H](OC)c2coc(n2)C[C@@H](O)C(C)(C)[C@@H](C[C@H](OC)[C@H](C)CCC(=O)[C@H](C)[C@H](C/C=C/N(C)C=O)OC)OC(=O)C[C@H](O)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1010,nan,,CCCCC(C)C1CC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1011,nan,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1012,nan,,CO[C@]1(C[C@@H]2C(=O)N[C@@H](c3ccc(O)cc3)CC(=O)O[C@@H](C)C[C@@H](C)/C=C(/C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N2C)OC(=O)Nc2ccccc21,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1013,CHEMBL396293,,C/C=C1\NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CCCC(C)C)C(C)C)[C@H](C)OC(C)=O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1014,nan,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCCNC)NC(=O)[C@@H](NC(=O)[C@H](O)COS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1015,nan,,CC[C@H](C)[C@H]1NC(=O)C(Cc2ccc(OC)cc2)NC(=O)[C@@H](NC(=O)[C@@H](NC=O)[C@H](C)CC)[C@@H](C)OC(=O)[C@H](C)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CCCNN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1016,nan,,CC(C)[C@@H]1OC(=O)[C@@H](C)N(O)C(=O)[C@@H]2CCCNN2C(=O)CNC(=O)[C@H](C)N(O)C(=O)[C@H]2CCCNN2C(=O)[C@H]1NC(=O)[C@@](C)(O)CCCc1ccccc1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1017,CHEMBL1076833,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](CO)OS(=O)(=O)O)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1018,nan,,C/C=C1\NC(=O)[C@H](CCC2CCCCC2)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@H](C)CC)[C@H](C)OC(=O)[C@H](C(C)C)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1019,nan,,CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2CC(=O)CCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1020,nan,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)O)OC)C(C)C)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1021,nan,,C=C/C=C(\C)[C@H](O)CC[C@@H](C)/C=C/[C@H]1CC[C@H](C)C(=O)CC(=O)N[C@@H](C)CCC(=O)[C@H](C)[C@@H](O)[C@@H](C)/C=C(/C)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1022,CHEMBL256304,MICROPEPTIN SD944,CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H]([C@@H](C)CC)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1023,CHEMBL1077010,MOLASSAMIDE,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CCC)[C@@H](C)O)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1024,nan,,CCC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(O)CCl)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1025,nan,,CCCCCCCC1OC1C(=O)N[C@@H]1C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc2c[nH]c3ccc(O)cc23)C(=O)N[C@@H](c2ccc(O)cc2)C(=O)NCC(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1026,nan,,C=C1NC(CC(C)C)C(=O)N[C@H](C(C)C)C(=O)N2NCCCC2C(=O)CC(CC(C)C)C(=O)N2NCCCC2C(=O)OC(C)[C@H]1NC(=O)[C@@H](NC=O)[C@@H](C)CC,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1027,CHEMBL519769,MICROPEPTIN 88 E,CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]2CC[C@@H](O)N(C2=O)[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@@H]1C)C(=O)O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1028,CHEMBL1076830,,CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H]([C@@H](C)CC)N2C(=O)[C@H](CC[C@H]2O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](O)CO)[C@@H](C)OC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1029,nan,,CC(C)[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@H](NC(=O)C[C@H](O)CCCCCCCCCCCCNC(=N)N)[C@@H](C)OC(=O)[C@@H](C)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1030,nan,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2ccc(O)c(Cl)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1031,nan,,C/C1=C/[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1032,CHEMBL3577228,,CCCCCC/C=C\CCC[C@@H]1CC(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1033,nan,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)[O-])OC)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1034,nan,,CC(=O)O[C@]1(C)CC(=O)OC[C@@H]2CC(C)=C[C@H]3O[C@@H]4C[C@@H](OC(=O)/C=C\C=C/[C@@H]([C@H](C)O)OC[C@@H]1O)[C@](C)([C@@H]32)[C@@]41CO1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1035,nan,,CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2CC(=O)[C@H](CS[C@@H]3CN4CCC3CC4)CN2C(=O)[C@H](Cc2ccc(N(C)C)cc2)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1036,CHEMBL539419,ISARIDIN C2,CC(C)CC1OC(=O)CCNC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2C(C)CCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1037,nan,,C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)O)OC)C(C)C)[C@@H](C)OC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1038,CHEMBL1783105,VERAGUAMIDE A,CC[C@H](C)[C@@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@@H](C)[C@@H](CCCC#CBr)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]2CCCN2C1=O,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1039,nan,,C#CCCC[C@H]1OC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1040,nan,,C/C1=C\[C@H](C)C[C@H](C)OC(=O)C[C@H](c2ccc(O)cc2)NC(=O)[C@H](Cc2ccc(O)c(Br)c2)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C1,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1041,nan,,CCCCCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H]2CC[C@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]1C,non_standard_macrocycle,19.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1042,CHEMBL605826,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C1(C)CCCCC1)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1043,CHEMBL1524593,,CO[C@H]1COC(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)[C@@H](C)COC(=O)C/C=C\[C@@H]1C,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1044,nan,,CCC/C=C/C=C/C(=O)O[C@H]1C2=CC(=O)O[C@@H]2[C@H]2C[C@H](C(C)=O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]4C/C(=C\C(=O)OC)C[C@H](/C=C\C(C)(C)[C@]1(O)O2)O4)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1045,nan,,C=C/C=C\[C@H](C)[C@H](O)[C@@H](C)[C@H]1CC[C@@H](C)C[C@H](C)[C@@H](O)[C@@H](C)/C=C\[C@@H](O)C[C@H](O)[C@H](C)/C=C/C=C\C(=O)O1,standard_macrolactone,20.0,,,success,,8.0,"[3, 6, 8, 9, 10, 13, 15, 16]",ring_size_20/standard/numbered/nan_numbered.png,2026-03-19 02:40:57.290303
1046,nan,,CO[C@H]1/C=C\C=C(/C)C(=O)OCc2cn(nn2)C[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)C(=O)O[C@H]1CO[Si](C)(C)C(C)(C)C,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1047,nan,,CCCC(=O)O[C@H]1C[C@H]2C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@H]3C/C(=C\C(=O)OC)[C@@H](OC(=O)CCC)[C@](O)(O3)C(C)(C)/C=C\[C@H]3C/C(=C\C(=O)OC)C[C@@H](C[C@](O)(O2)C1(C)C)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1048,nan,,C=C(C)CC(=O)N/C=C/C(C)=C/[C@@H](C)[C@H]1C/C(C)=C\C=C/CC[C@H](OC(N)=O)[C@@H](O)/C=C\[C@@H](O)CCC/C=C\C(=O)O1,standard_macrolactone,20.0,,,success,,5.0,"[3, 5, 11, 12, 15]",ring_size_20/standard/numbered/nan_numbered.png,2026-03-19 02:40:57.337729
1049,nan,,CO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](OC)[C@@H](O)/C=C(C)/C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](OC)C[C@H](OC)[C@]13CO3)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1050,CHEMBL599873,,C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC1(CCCCc3cccc4c3CN(C4)C(=O)O2)CCC1)C(=O)NS(=O)(=O)C1CC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1051,nan,,CCCC(=O)O[C@H]1C[C@H]2C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@@H](OC(C)=O)[C@@](O)(O3)C(C)(C)/C=C\[C@H]3C/C(=C/C(=O)OC)C[C@@H](C[C@](O)(O2)C1(C)C)O3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1052,CHEMBL501873,,CCC[C@H](NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCCCCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)C(=O)CC1CC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1053,nan,,CC(C)CC1NC(=O)C(C(C)C)NC(=O)CC(C)COC(=O)C(CC(C)C)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)OC1=O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1054,nan,,CC[C@@H]1/C=C\[C@H](O)[C@H](C=C(C)C)OC(=O)/C(C)=C\CC(=O)Nc2cc(O)cc3c2O/C(=C\C(=O)CC1)C=C3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1055,nan,,COC(=O)/C=C1/C[C@H]2C[C@]3(O)O[C@@H](C[C@H](OC(=O)CC(C)C)C3(C)C)C[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]3C/C(=C\C(=O)OC)[C@H](OC(C)=O)[C@@](O)(O3)C(C)(C)/C=C\[C@@H](C1)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1056,CHEMBL3674588,,CCCCCCCCCCCC/C=C/c1ccc([C@@H]2C[C@@H]3CCO[C@H](/C=C/C(C)(C)[C@]4(O)O[C@@H](C/C(=C\C(=O)OC)[C@@H]4OC(=O)CCCCCCC)C[C@H](CO)OC(=O)C[C@H](O)CCO2)O3)cc1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1057,nan,,CO[C@H]1C[C@@H]2CC=C[C@@H](C[C@@H](O)C/C=C(C)/C=C/C(=O)O[C@H]([C@@H](C)[C@@H](O)[C@@H](C)CCC(=O)[C@H](C)[C@H](OC)[C@H](C)/C=C/N(C)C=O)[C@@H](C)[C@H](O)C[C@H](OC)[C@@H]1C)O2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1058,nan,,CC[C@H]1/C=C\[C@H](O)[C@H](C=C(C)C)OC(=O)/C(C)=C\CC(=O)Nc2cc(O)cc3c2O/C(=C\C(=O)CC1)C(C)=C3,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1059,CHEMBL1514135,,CO[C@@H]1COC(=O)C/C=C\[C@H](C)[C@@H](OC)COC(=O)[C@H](C)COC(=O)C/C=C\[C@H]1C,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1060,CHEMBL454218,IPOMOEASSIN B,C/C=C(\C)C(=O)O[C@@H]1[C@@H](O)[C@H]2O[C@H](COC(=O)CCC(=O)CCCCCC[C@H](CCC)O[C@@H]3O[C@H](C)[C@H](O)[C@H](O)[C@H]3O2)[C@H]1OC(=O)/C=C/c1ccccc1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1061,nan,,CCCCC[C@H]1CCCCCCCCCC(=O)OC[C@H]2O[C@@H](O[C@@H]3[C@@H](O)[C@@H](O)[C@@H](C)O[C@H]3O1)[C@H](O[C@@H]1O[C@@H](C)[C@H](OC(=O)[C@@H](C)CC)[C@@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@H]1OC(=O)[C@@H](C)CC)[C@@H](O)[C@@H]2O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1062,CHEMBL527062,,C=CC1CC1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)P(C)(=O)O,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1063,CHEMBL94864,,O=C1Cn2c(Cl)cnc(c2=O)N[C@@H](Cc2ccccc2)CNC(=O)OC/C=C/COc2ccc(Cl)cc2CN1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1064,nan,,CC(C)C[C@H]1NC(=O)CO[C@@H]2C/C=C\C=C/C=C\C[C@@H](O)[C@@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@](C)(OC(=O)[C@@H]3C[C@@H](CC[C@H]3O)NC(=O)[C@@H](C(C)C)NC1=O)O[C@@H](C)C2,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1065,CHEMBL1256598,,CC1(C)CCCCc2cccc3c2CN(C3)C(=O)O[C@@H]2C[C@@H](C(=O)N[C@@H]3BOCC3)N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)OC1,non_standard_macrocycle,20.0,contains_non_carbon_ring_atoms_outside_positions_1_2,Ring positions 3..N contain non-carbon atoms.,skipped,,,,,
1066,nan,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)C[C@H](O)[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3[C@@H](C)C(=O)C[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C)C(=O)O[C@H]2CO)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1067,nan,,Cc1ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2c1Oc1c(c(C(=O)N[C@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]3C)c3nc(-c4ccc(Cl)cc4Cl)c(=O)oc3c1C)N2,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1068,nan,,Cc1c2oc3c(C)cnc(C(=O)NC4C(=O)NC(C(C)C)C(=O)N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)c3nc-2c(C(=O)NC2C(=O)NC(C(C)C)C(=O)N3CCCC3C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1069,CHEMBL3218172,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N\OCc5cc(OC)c(OC)c(OC)c5)[C@H](C)C[C@@]4(C)OC)[C@@H]3O)[C@H]2O)[C@](C)(OC)C[C@@H](C)/C(=N/OCc2cc(OC)c(OC)c(OC)c2)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1070,nan,,CCCCCc1c(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/CCc4cccc(c4)CC4CC(CCC4=O)C3(O)CCC)C2)cc1NCC(C)O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
1071,nan,,CCCCCc1c(CO)cc(C2C#CC3CC(=O)Oc4c3cc(c(O)c4C3C=CC=CC3)CC3OC(=O)/C(=C/C(O)Cc4cccc(c4)CC4CC(CCC4=O)C3(O)CCC)C2)cc1NCC(C)O,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
1072,nan,,COC(=O)C[C@@H]1C(=O)CC[C@H](C)C(=O)O[C@H]2[C@@H](OC(C)=O)[C@]3(COC1=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(=O)[C@](C)(O)[C@H](C)c4ccncc4C(=O)OC[C@]4(C)O[C@@]3([C@H](OC(C)=O)[C@@H]24)[C@@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1073,nan,,CCCCNc1c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c2nc3c(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)ccc(C)c3oc-2c(C)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1074,nan,,CC[C@@H]1OC(=O)C[C@H](O)[C@@H](C)[C@H](OC2OC(C)C(O)C(N(C)C)C2O)[C@H](CCNCC[C@H]2C[C@@H](C)C(=O)/C=C/C(C)=C/C(COC3OC(C)C(O)C(OC)C3OC)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]2OC2OC(C)C(O)C(N(C)C)C2O)C[C@H](C)C(=O)/C=C/C(C)=C/C1COC1OC(C)C(O)C(OC)C1OC,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1075,nan,,CC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/C(O)C4(CCCC4)c4cccc(c4)CC4C(=O)CCC5C4CCCC35O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
1076,nan,,CCc1nc2c(C(=O)N[C@@H]3C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]3C)c3c(c(C)c2oc1=O)Oc1c(C)ccc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c1N3,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1077,nan,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(CO)cc(NCC(C)(O)CCOC5CCCC5)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5C4CCCCC4)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
1078,nan,,COCCC(C)(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C/CCc4cccc(c4)CC4CC(CCC4=O)C3(C)O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
1079,nan,,CCCCCCCCCCCNc1c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c2nc3c(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)ccc(C)c3oc-2c(C)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1080,nan,,C[C@H]1CCCCC[C@@H](O)C(=O)[C@H](S[C@@H]2CC(=O)O[C@@H](C)CCCCC[C@@H](O)C2=O)CC(=O)O1,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1081,nan,,Cc1c2oc3c(C)c(OCC4CN4)cc(C(=O)NC4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)NC2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1082,nan,,CCN1CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)c2c3c(c(C)c4oc(=O)c(-c5ccccc5)nc24)Oc2c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c2N3)C(=O)N[C@H](C(C)C)C(=O)N2CCC[C@H]2C1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1083,nan,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(NCCCCCCCCCCN)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1084,CHEMBL4073368,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@@H](C)C[C@H](O)[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CC(=O)C[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1085,CHEMBL2369146,,Cc1c2oc3c(C)c(OCC4CO4)cc(C(=O)N[C@@H]4C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1086,nan,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)C3(CCCC3)C(O)/C=C3\CC(c4cc(CO)cc(NCC(C)O)c4)C#CC4CC(=O)Oc5c4cc(c(O)c5C4C=CC=CC4)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
1087,nan,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(NCCCCCN)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1088,CHEMBL2369550,,CC[C@@H](C)[C@H]1NC(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)c2c3nc4c(C(=O)N[C@@H]5C(=O)N[C@H]([C@H](C)CC)C(=O)N6CCC[C@H]6C(=O)N(C)CC(=O)N[C@H]([C@H](C)CC)C(=O)O[C@@H]5C)ccc(C)c4oc-3c(C)c(=O)c2N)[C@@H](C)OC1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1089,nan,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC/C=C3\CC(c4cc(NCC(C)O)cc(C(O)CNC)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
1090,nan,,C/C=C1\NC(=O)[C@H]([C@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H]2CC(=O)O[C@H](C(=O)O)[C@H](NC1=O)C(=O)N[C@@H]([C@H](O)CCl)C(=O)OC[C@H](NC(=O)C[C@H](O)CCCCCCCCCCC)C(=O)N[C@H](CCN)C(=O)N2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
1091,nan,,Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H]([C@H](C)O)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1092,nan,,Cc1c2oc3c(C)c(OC(=O)Cc4ccc(Cl)c(Cl)c4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@H](C(C)C)C(=O)O[C@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1093,nan,,Cc1c2oc3c(C)c(NCc4ccc(C(F)(F)F)cc4)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
1094,nan,,CC1(O)C2CCC(=O)C(Cc3ccc4c(c3)CC(O)/C(=C3\CC(c5cc(O)cc(CO)c5)C#CC5CC(=O)Oc6cc(O)c(cc65)CC1OC3=O)CC4)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
1095,nan,,CCCC1(O)C2CCC(=O)C(Cc3cccc(c3)CC(O)/C=C3\CC(c4cc(O)cc(C(O)CNC)c4)C#CC4CC(=O)Oc5cc(O)c(cc54)CC1OC3=O)C2,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
1096,nan,,CC(O)CNc1cc(CO)cc(C2C#CC3CC(=O)Oc4cc(O)c(cc43)CC3OC(=O)/C(=C4\CCc5ccc(cc5CC4)CC4CC(CCC4=O)C3(C)O)C2)c1,non_standard_macrocycle,,multiple_overlapping_macrocycle_candidates,Overlapping macrolactone candidate rings were detected.,skipped,,,,,
1097,nan,,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN(C)[C@H]3C[C@@H](C)O[C@@H](O[C@@H]4[C@@H](C)[C@H](O[C@H]5C[C@@](C)(OC)[C@@H](O)[C@H](C)O5)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)/C(=N\OCc5ccccc5)[C@H](C)C[C@@]4(C)O)[C@@H]3O)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O,not_macrolactone,,classification_error,Multiple valid macrolactone candidates were detected. Pass ring_size explicitly.,skipped,,,,,
