first add

backend/app/core/celery_app.py

@@ -1,3 +1,18 @@
+from celery import Celery
+from .config import settings
+
+
+celery_app = Celery(
+    "bttoxin",
+    broker=settings.get_celery_broker_url(),
+    backend=settings.get_celery_result_backend(),
+)
+
+celery_app.conf.update(
+    task_track_started=True,
+    worker_prefetch_multiplier=1,
+)
+
 """Celery 配置"""
 from celery import Celery
 from ..config import settings

backend/app/core/config.py

@@ -0,0 +1,96 @@
+"""应用配置"""
+from typing import Optional
+from pydantic_settings import BaseSettings, SettingsConfigDict
+
+
+class Settings(BaseSettings):
+    """应用配置"""
+
+    model_config = SettingsConfigDict(
+        env_file=".env",
+        env_file_encoding="utf-8",
+        case_sensitive=False,
+    )
+
+    # ============== 应用基础配置 ==============
+    APP_NAME: str = "BtToxin Pipeline"
+    APP_VERSION: str = "1.0.0"
+    DEBUG: bool = False
+
+    # API 配置
+    API_V1_PREFIX: str = "/api/v1"
+
+    # ============== 数据库配置 ==============
+    POSTGRES_HOST: str = "localhost"
+    POSTGRES_PORT: int = 5432
+    POSTGRES_USER: str = "bttoxin"
+    POSTGRES_PASSWORD: str = "bttoxin_password"
+    POSTGRES_DB: str = "bttoxin_db"
+
+    @property
+    def DATABASE_URL(self) -> str:
+        """数据库连接 URL"""
+        return (
+            f"postgresql://{self.POSTGRES_USER}:{self.POSTGRES_PASSWORD}"
+            f"@{self.POSTGRES_HOST}:{self.POSTGRES_PORT}/{self.POSTGRES_DB}"
+        )
+
+    # ============== Redis 配置 ==============
+    REDIS_HOST: str = "localhost"
+    REDIS_PORT: int = 6379
+    REDIS_DB: int = 0
+    REDIS_PASSWORD: Optional[str] = None
+
+    @property
+    def REDIS_URL(self) -> str:
+        """Redis 连接 URL"""
+        if self.REDIS_PASSWORD:
+            return f"redis://:{self.REDIS_PASSWORD}@{self.REDIS_HOST}:{self.REDIS_PORT}/{self.REDIS_DB}"
+        return f"redis://{self.REDIS_HOST}:{self.REDIS_PORT}/{self.REDIS_DB}"
+
+    # ============== Celery 配置 ==============
+    CELERY_BROKER_URL: Optional[str] = None
+    CELERY_RESULT_BACKEND: Optional[str] = None
+
+    def get_celery_broker_url(self) -> str:
+        """获取 Celery Broker URL"""
+        return self.CELERY_BROKER_URL or self.REDIS_URL
+
+    def get_celery_result_backend(self) -> str:
+        """获取 Celery Result Backend URL"""
+        return self.CELERY_RESULT_BACKEND or self.REDIS_URL
+
+    # ============== 工作空间配置 ==============
+    WORKSPACE_BASE_PATH: str = "/data/jobs"
+    TEMP_BASE_PATH: str = "/data/temp"
+    MAX_UPLOAD_SIZE_MB: int = 500
+
+    # ============== Docker 配置 ==============
+    DOCKER_IMAGE: str = "quay.io/biocontainers/bttoxin_digger:1.0.10--hdfd78af_0"
+    DOCKER_PLATFORM: str = "linux/amd64"
+
+    # ============== S3 配置 ==============
+    S3_ENDPOINT: Optional[str] = None
+    S3_ACCESS_KEY: Optional[str] = None
+    S3_SECRET_KEY: Optional[str] = None
+    S3_BUCKET: str = "bttoxin-results"
+    S3_REGION: str = "us-east-1"
+
+    # ============== 任务配置 ==============
+    DEFAULT_THREADS: int = 4
+    MAX_THREADS: int = 16
+    TASK_TIMEOUT_SECONDS: int = 7200  # 2小时
+    JOB_RETENTION_DAYS: int = 30
+
+    # ============== CORS 配置 ==============
+    CORS_ORIGINS: list = ["http://localhost:3000", "http://localhost:5173"]
+
+    # ============== 日志配置 ==============
+    LOG_LEVEL: str = "INFO"
+    LOG_FORMAT: str = "%(asctime)s - %(name)s - %(levelname)s - %(message)s"
+
+
+# 创建全局配置实例
+settings = Settings()
+
+

backend/app/core/database.py

@@ -0,0 +1,50 @@
+"""SQLModel 数据库配置"""
+from typing import Generator
+from sqlmodel import Session, create_engine
+from sqlalchemy.orm import sessionmaker
+from .config import settings
+
+
+# 创建数据库引擎
+engine = create_engine(
+    settings.DATABASE_URL,
+    echo=settings.DEBUG,
+    pool_pre_ping=True,
+    pool_size=10,
+    max_overflow=20,
+)
+
+# 创建 SessionLocal
+SessionLocal = sessionmaker(
+    autocommit=False,
+    autoflush=False,
+    bind=engine,
+    class_=Session,
+)
+
+
+def get_session() -> Generator[Session, None, None]:
+    """
+    获取数据库会话（依赖注入）
+    """
+    with SessionLocal() as session:
+        yield session
+
+
+def init_db() -> None:
+    """初始化数据库（创建所有表）"""
+    from sqlmodel import SQLModel
+    from ..models.job import Job, Step, JobLog  # noqa: F401
+
+    SQLModel.metadata.create_all(engine)
+    print("✓ Database initialized")
+
+
+def drop_db() -> None:
+    """删除所有表（开发用）"""
+    from sqlmodel import SQLModel
+
+    SQLModel.metadata.drop_all(engine)
+    print("✓ Database dropped")
+
+

backend/app/core/logging.py

@@ -0,0 +1,14 @@
+import logging
+import sys
+
+
+def setup_logging(level: str = "INFO", fmt: str = "%(asctime)s - %(name)s - %(levelname)s - %(message)s") -> None:
+    handler = logging.StreamHandler(sys.stdout)
+    formatter = logging.Formatter(fmt)
+    handler.setFormatter(formatter)
+    root = logging.getLogger()
+    if not root.handlers:
+        root.addHandler(handler)
+    root.setLevel(level)
+
+