diff --git a/README.md b/README.md
index 04e13c4..77d4dbe 100644
--- a/README.md
+++ b/README.md
@@ -4,6 +4,13 @@ Automated Bacillus thuringiensis toxin mining system with CI/CD integration.
 
 ## Quick Start (单机部署)
 
+### uv .venv
+
+```bash
+uv venv --managed-python -p 3.12 --seed .venv
+uv pip install backend/requirements.txt
+```
+
 ### Prerequisites
 
 - Docker / Podman